@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y0T1: (2018-01-22 )
MKLGFIGTGVMGSAVARHLLEAGHEVAVYNRTKAKADPLVTEGAIWADTPKAVAEQSNILFTMVGYPKDVEEIYYGQSGIFSADISGHILVDLTTSTPSLAEKIAKTAKEKGADALDAPVSGGDLGAKNGTLTIMVGGEEAVYDQVLPLFKEFGTTFTLHGSAGKGQHTKMANQIMIAGTMTGMTEMLVYAQKNGLDLKKVIETLSGGSAANWSLSNYSPRILKEDYTPGFFVKHFIKDLKIALEEAEKMDLVLPATTQALKLYEELADKGFENDGTQALIKLWWPEGKIPEKKS
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70.....-...80........90........100.......110.......120.......130.......140.......150....-...160.......170.......180.......190.......200..------------------.--....210...-...--.220-----.-------..-----......230.......240.......250.......260.......270.......280.......290...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
L
G
F
IGT
G
V
M
G
S
A
V
A
R
H
L
L
EAGH
E
V
A
V
Y
NRTKAKADPLVTEGAIWAD
T
P
K
A
V
AEQS
N
I
L
F
T
MVGYP
K
D
V
E
E
I
YYG-QSGIFSADIS
G
H
I
L
V
D
L
TTS
T
P
S
L
A
E
K
I
A
K
T
A
K
EKGADALDAPVSGGDLGAKN
G
T
L
T
I
M
VGG
E
E
A
V
Y
D
Q
V
L
P
L
F
K
EFG
T
T
-
F
T
L
HGSAGKG
Q
H
T
KMA
N
Q
I
M
I
AGTMT
G
M
T
E
M
L
V
Y
A
QKNGL
D
L
K
K
V
I
E
T
------------------L--SGGSAANWSL-SNY--S
P
-------
R
-------
I
L
-----KEDYT
P
G
F
F
V
K
H
F
I
K
D
L
K
I
A
L
E
E
A
EKM
D
L
VLPA
T
T
Q
A
L
K
L
Y
E
E
L
A
DKGFEND
G
T
Q
A
L
I
K
L
WWPEGKIPEKKS
1
PsiBlast_PDB
84.41
41%
-126
- C1 -
-
3WS7
2
?
A:
[21-300]
M
R
V
G
F
I
G
L
G
I
M
G
G
P
M
A
T
H
L
L
K
A
G
F
L
A
A
V
Y
N
R
T
R
E
K
T
K
P
F
A
E
A
G
V
Y
V
A
E
S
P
A
D
L
A
K
R
V
D
V
V
I
V
M
V
S
D
A
P
D
V
E
Q
V
L
F
G
-
P
S
G
V
V
E
G
A
R
P
G
L
I
V
V
D
M
S
T
N
S
P
D
W
A
R
K
F
A
E
R
L
A
Q
Y
G
I
E
F
L
D
A
P
V
T
G
G
Q
K
G
A
I
E
G
T
L
T
I
M
V
G
G
K
E
E
L
F
H
R
L
L
P
I
F
K
A
M
G
R
D
-
I
V
Y
M
G
P
V
G
Y
G
Q
A
M
K
L
V
N
Q
V
V
V
A
L
N
T
V
A
M
V
E
G
L
K
L
A
K
A
L
G
L
D
M
D
K
V
A
E
V
------------------
L
--
T
---
A
R
S
G
A
I
-
E
L
Y
--
L
P
-------
K
-------
L
L
-----
K
G
D
L
S
P
G
F
K
A
E
H
L
K
K
D
L
G
Y
V
L
E
E
A
R
K
R
G
V
K
L
P
G
A
E
L
A
Y
E
L
Y
R
K
M
V
E
D
G
A
G
S
L
G
I
H
A
L
---------------
74
HHSearch
84.22
34%
-101
- C1 -
-
1VPD
1
?
A:
[6-298]
M
K
V
G
F
I
G
L
G
I
M
G
K
P
M
S
K
N
L
L
K
A
G
Y
S
L
V
V
S
D
R
N
P
E
A
I
A
D
V
I
A
A
G
A
E
T
A
S
T
A
K
A
I
A
E
Q
C
D
V
I
I
T
M
L
P
N
S
P
H
V
K
E
V
A
L
G
-
E
N
G
I
I
E
G
A
K
P
G
T
V
L
I
D
M
S
S
I
A
P
L
A
S
R
E
I
S
D
A
L
K
A
K
G
V
E
M
L
D
A
P
V
S
G
G
E
P
K
A
I
D
G
T
L
S
V
M
V
G
G
D
K
A
I
F
D
K
Y
Y
D
L
M
K
A
M
A
G
S
-
V
V
H
T
G
D
I
G
A
G
N
V
T
K
L
A
N
Q
V
I
V
A
L
N
I
A
A
M
S
E
A
L
T
L
A
T
K
A
G
V
N
P
D
L
V
Y
Q
A
------------------
I
--
R
G
G
L
A
G
S
T
V
L
-
D
A
K
--
A
P
-------
M
-------
V
M
-----
D
R
N
F
K
P
G
F
R
I
D
L
H
I
K
D
L
A
N
A
L
D
T
S
H
G
V
G
A
Q
L
P
L
T
A
A
V
M
E
M
M
Q
A
L
R
A
D
G
H
G
N
D
D
H
S
A
L
A
C
Y
Y
E
K
L
A
K
V
E
V
T
--
2
PsiBlast_PDB
83.25
40%
-127
- C1 -
-
3W6Z
1
?
A:
[21-300]
M
R
V
G
F
I
G
L
G
I
M
G
G
P
M
A
T
H
L
L
K
A
G
F
L
A
A
V
Y
N
R
T
R
E
K
T
K
P
F
A
E
A
G
V
Y
V
A
E
S
P
A
D
L
A
K
R
V
D
V
V
I
V
M
V
S
D
A
P
D
V
E
Q
V
L
F
G
-
P
S
G
V
V
E
G
A
R
P
G
L
I
V
V
D
M
S
T
N
S
P
D
W
A
R
K
F
A
E
R
L
A
Q
Y
G
I
E
F
L
D
A
P
V
T
G
G
Q
K
G
A
I
E
G
T
L
T
I
M
V
G
G
K
E
E
L
F
H
R
L
L
P
I
F
K
A
M
G
R
D
-
I
V
Y
M
G
P
V
G
Y
G
Q
A
M
M
L
V
N
Q
V
V
V
A
L
N
T
V
A
M
V
E
G
L
K
L
A
K
A
L
G
L
D
M
D
K
V
A
E
V
------------------
L
--
T
R
G
A
A
R
S
G
A
I
-
E
L
Y
--
L
P
-------
K
-------
L
L
-----
K
G
D
L
S
P
G
F
K
A
E
H
L
K
K
D
L
G
Y
V
L
E
E
A
R
K
R
G
V
K
L
P
G
A
E
L
A
Y
E
L
Y
R
K
M
V
E
D
G
A
G
S
L
G
I
H
A
L
---------------
62
HHSearch
82.66
34%
-98
- C1 -
-
4DLL
-
?
A:
[32-316]
R
K
I
T
F
L
G
T
G
S
M
G
L
P
M
A
R
R
L
C
E
A
G
Y
A
L
Q
V
W
N
R
T
P
A
R
A
A
S
L
A
A
L
G
A
T
I
H
E
Q
A
R
A
A
A
R
D
A
D
I
V
V
S
M
L
E
N
G
A
V
V
Q
D
V
L
F
A
--
Q
G
V
A
A
A
M
K
P
G
S
L
F
L
D
M
A
S
I
T
P
R
E
A
R
D
H
A
A
R
L
G
A
L
G
I
A
H
L
D
T
P
V
S
G
G
T
V
G
A
E
Q
G
T
L
V
I
M
A
G
G
K
P
A
D
F
E
R
S
L
P
L
L
K
V
F
G
R
--
A
T
H
V
G
P
H
G
S
G
Q
L
T
K
L
A
N
Q
M
I
V
G
I
T
I
G
A
V
A
E
A
L
L
F
A
T
K
G
G
A
D
M
A
K
V
K
E
A
------------------
I
--
T
G
G
F
A
D
S
R
V
L
-
Q
L
H
--
G
Q
-------
R
-------
M
V
-----
E
R
D
F
A
P
R
A
R
L
S
I
Q
L
K
D
M
R
N
A
L
A
T
A
Q
E
I
G
F
D
A
P
I
T
G
L
F
E
Q
L
Y
A
E
G
V
E
H
G
L
T
D
L
D
Q
S
G
L
F
V
E
L
A
S
R
--------
61
HHSearch
82.30
34%
-104
- C1 -
-
4DLL
-
?
B:
[32-318]
R
K
I
T
F
L
G
T
--
M
G
L
P
M
A
R
R
L
C
E
A
G
Y
A
L
Q
V
W
N
R
T
P
A
R
A
A
S
L
A
A
L
G
A
T
I
H
E
Q
A
R
A
A
A
R
D
A
D
I
V
V
S
M
L
E
N
G
A
V
V
Q
D
V
L
F
A
--
Q
G
V
A
A
A
M
K
P
G
S
L
F
L
D
M
A
S
I
T
P
R
E
A
R
D
H
A
A
R
L
G
A
L
G
I
A
H
L
D
T
P
V
S
G
G
T
V
G
A
E
Q
G
T
L
V
I
M
A
G
G
K
P
A
D
F
E
R
S
L
P
L
L
K
V
F
G
R
--
A
T
H
V
G
P
H
G
S
G
Q
L
T
K
L
A
N
Q
M
I
V
G
I
T
I
G
A
V
A
E
A
L
L
F
A
T
K
G
G
A
D
M
A
K
V
K
E
A
------------------
I
--
T
G
G
F
A
D
S
R
V
L
-
Q
L
H
--
G
Q
-------
R
-------
M
V
-----
E
R
D
F
A
P
R
A
R
L
S
I
Q
L
K
D
M
R
N
A
L
A
T
A
Q
E
I
G
F
D
A
P
I
T
G
L
F
E
Q
L
Y
A
E
G
V
E
H
G
L
T
D
L
D
Q
S
G
L
F
V
E
L
A
S
R
N
G
------
5
PsiBlast_PDB
81.60
32%
-108
- C1 -
-
3PEF
6
?
A:
[3-285]
-
K
F
G
F
I
G
L
G
I
M
G
S
A
M
A
K
N
L
V
K
A
G
C
S
V
T
I
W
N
R
S
P
E
K
A
E
E
L
A
A
L
G
A
E
R
A
A
T
P
C
E
V
V
E
S
C
P
V
T
F
A
M
L
A
D
P
A
A
A
E
E
V
C
F
G
-
K
H
G
V
L
E
G
I
G
E
G
R
G
Y
V
D
M
S
T
V
D
P
A
T
S
Q
R
I
G
V
A
V
V
A
K
G
G
R
F
L
E
A
P
V
S
G
S
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
R
N
L
Y
D
E
A
M
P
G
F
E
K
M
G
K
K
-
I
I
H
L
G
D
V
G
K
G
A
E
M
K
L
V
V
N
M
V
M
G
G
M
M
A
C
F
C
E
G
L
A
L
G
E
K
A
G
L
A
T
D
A
I
L
D
V
------------------
I
--
G
A
G
A
M
A
N
P
M
F
-
A
L
K
--
G
G
-------
L
-------
I
R
-----
D
R
N
F
A
P
A
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
A
L
G
D
R
V
G
Q
P
L
V
A
S
A
A
A
N
E
L
F
K
G
A
R
A
A
G
F
G
D
E
D
F
S
A
I
F
K
T
Y
-----------
56
HHSearch
81.41
32%
-102
- C1 -
-
3PEF
2
?
C:
[2-286]
Q
K
F
G
F
I
G
L
G
I
M
G
S
A
M
A
K
N
L
V
K
A
G
C
S
V
T
I
W
N
R
S
P
E
K
A
E
E
L
A
A
L
G
A
E
R
A
A
T
P
C
E
V
V
E
S
C
P
V
T
F
A
M
L
A
D
P
A
A
A
E
E
V
C
F
G
-
K
H
G
V
L
E
G
I
G
E
G
R
G
Y
V
D
M
S
T
V
D
P
A
T
S
Q
R
I
G
V
A
V
V
A
K
G
G
R
F
L
E
A
P
V
S
G
S
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
R
N
L
Y
D
E
A
M
P
G
F
E
K
M
G
K
K
-
I
I
H
L
G
D
V
G
K
G
A
E
M
K
L
V
V
N
M
V
M
G
G
M
M
A
C
F
C
E
G
L
A
L
G
E
K
A
G
L
A
T
D
A
I
L
D
V
------------------
I
--
G
A
G
A
M
A
N
P
M
F
-
A
L
K
--
G
G
-------
L
-------
I
R
-----
D
R
N
F
A
P
A
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
A
L
G
D
R
V
G
Q
P
L
V
A
S
A
A
A
N
E
L
F
K
G
A
R
A
A
G
F
G
D
E
D
F
S
A
I
F
K
T
Y
E
----------
6
PsiBlast_PDB
81.32
32%
-104
- C1 -
-
1VPD
1
?
A:
[7-295]
-
K
V
G
F
I
G
L
G
I
M
G
K
P
M
S
K
N
L
L
K
A
G
Y
S
L
V
V
S
D
R
N
P
E
A
I
A
D
V
I
A
A
G
A
E
T
A
S
T
A
K
A
I
A
E
Q
C
D
V
I
I
T
M
L
P
N
S
P
H
V
K
E
V
A
L
G
-
E
N
G
I
I
E
G
A
K
P
G
T
V
L
I
D
M
S
S
I
A
P
L
A
S
R
E
I
S
D
A
L
K
A
K
G
V
E
M
L
D
A
P
V
S
G
G
E
P
K
A
I
D
G
T
L
S
V
M
V
G
G
D
K
A
I
F
D
K
Y
Y
D
L
M
K
A
M
A
G
S
-
V
V
H
T
G
D
I
G
A
G
N
V
T
K
L
A
N
Q
V
I
V
A
L
N
I
A
A
M
S
E
A
L
T
L
A
T
K
A
G
V
N
P
D
L
V
Y
Q
A
------------------
I
--
R
G
G
L
A
G
S
T
V
L
-
D
A
K
--
A
P
-------
M
-------
V
M
-----
D
R
N
F
K
P
G
F
R
I
D
L
H
I
K
D
L
A
N
A
L
D
T
S
H
G
V
G
A
Q
L
P
L
T
A
A
V
M
E
M
M
Q
A
L
R
A
D
G
H
G
N
D
D
H
S
A
L
A
C
Y
Y
E
K
L
A
K
V
-----
60
HHSearch
80.99
27%
-106
* C1 *
-
3PDU
4
?
D:
[2-286]
T
T
Y
G
F
L
G
L
G
I
M
G
G
P
M
A
A
N
L
V
R
A
G
F
D
V
T
V
W
N
R
N
P
A
K
C
A
P
L
V
A
L
G
A
R
Q
A
S
S
P
A
E
V
C
A
A
C
D
I
T
I
A
M
L
A
D
P
A
A
A
R
E
V
C
F
G
-
A
N
G
V
L
E
G
I
G
G
G
R
G
Y
I
D
M
S
T
V
D
D
E
T
S
T
A
I
G
A
A
V
T
A
R
G
G
R
F
L
E
A
P
V
S
G
T
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
Q
S
L
F
T
D
A
G
P
A
F
A
A
L
G
K
K
-
C
L
H
L
G
E
V
G
Q
G
A
R
M
K
L
V
V
N
M
I
M
G
Q
M
M
T
A
L
G
E
G
M
A
L
G
R
N
C
G
L
D
G
G
Q
L
L
E
V
------------------
L
--
D
A
G
A
M
A
N
P
M
F
-
K
G
K
--
G
Q
-------
M
-------
L
L
-----
S
G
E
F
P
T
S
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
E
L
G
D
R
L
G
Q
P
L
H
G
A
A
T
A
N
E
S
F
K
R
A
R
A
A
G
H
A
D
E
D
F
A
A
V
F
R
V
L
E
----------
65
HHSearch
79.88
33%
-93
- C1 -
-
3OBB
2
SERDH_PSEAE
A:
[4-298]
K
Q
I
A
F
I
G
L
G
H
M
G
A
P
M
A
T
N
L
L
K
A
G
Y
L
L
N
V
F
D
L
V
Q
S
A
V
D
G
L
V
A
A
G
A
S
A
A
R
S
A
R
D
A
V
Q
G
A
D
V
V
I
S
M
L
P
A
S
Q
H
V
E
G
L
Y
L
D
-
D
D
G
L
L
A
H
I
A
P
-
T
L
V
L
E
C
S
T
I
A
P
T
S
A
R
K
I
H
A
A
A
R
E
R
G
L
A
M
L
D
A
P
V
S
G
G
T
A
G
A
A
A
G
T
L
T
F
M
V
G
G
D
A
E
A
L
E
K
A
R
P
L
F
E
A
M
G
R
N
-
I
F
H
A
G
P
D
G
A
G
Q
V
A
K
V
C
N
N
Q
L
L
A
V
L
M
I
G
T
A
E
A
M
A
L
G
V
A
N
G
L
E
A
K
V
L
A
E
I
------------------
M
--
R
R
S
S
G
G
N
W
A
L
-
E
V
Y
--
N
P
-------
W
PGVMENA
P
A
-----
S
R
D
Y
S
G
G
F
M
A
Q
L
M
A
K
D
L
G
L
A
Q
E
A
A
Q
A
S
A
S
S
T
P
M
G
S
L
A
L
S
L
Y
R
L
L
L
K
Q
G
Y
A
E
R
D
F
S
V
V
Q
K
L
F
D
P
T
Q
-------
67
HHSearch
79.60
27%
-113
- C1 -
-
2UYY
-
GLYR1_HUMAN
C:
[31-315]
K
K
I
G
F
L
G
L
G
L
M
G
S
G
I
V
S
N
L
L
K
M
G
H
T
V
T
V
W
N
R
T
A
E
K
C
D
L
F
I
Q
E
G
A
R
L
G
R
T
P
A
E
V
V
S
T
C
D
I
T
F
A
C
V
S
D
P
K
A
A
K
D
L
V
L
G
-
P
S
G
V
L
Q
G
I
R
P
G
K
C
Y
V
D
M
S
T
V
D
A
D
T
V
T
E
L
A
Q
V
I
V
S
R
G
G
R
F
L
E
A
P
V
S
G
N
Q
Q
L
S
N
D
G
M
L
V
I
L
A
A
G
D
R
G
L
Y
E
D
C
S
S
C
F
Q
A
M
G
K
T
-
S
F
F
L
G
E
V
G
N
A
A
K
M
M
L
I
V
N
M
V
Q
G
S
F
M
A
T
I
A
E
G
L
T
L
A
Q
V
T
G
Q
S
Q
Q
T
L
L
D
I
------------------
L
--
N
Q
G
Q
L
A
S
I
F
L
-
D
Q
K
--
C
Q
-------
N
-------
I
L
-----
Q
G
N
F
K
P
D
F
Y
L
K
Y
I
Q
K
D
L
R
L
A
I
A
L
G
D
A
V
N
H
P
T
P
M
A
A
A
A
N
E
V
Y
K
R
A
K
A
L
D
Q
S
D
N
D
M
S
A
V
Y
R
A
Y
I
----------
59
HHSearch
79.29
27%
-98
- C1 -
-
3DOJ
-
GLYR1_ARATH
A:
[22-309]
M
E
V
G
F
L
G
L
G
I
M
G
K
A
M
S
M
N
L
L
K
N
G
F
K
V
T
V
W
N
R
T
L
S
K
C
D
E
L
V
E
H
G
A
S
V
C
E
S
P
A
E
V
I
K
K
C
K
Y
T
I
A
M
L
S
D
P
C
A
A
L
S
V
V
F
D
-
K
G
G
V
L
E
Q
I
C
E
G
K
G
Y
I
D
M
S
T
V
D
A
E
T
S
L
K
I
N
E
A
I
T
G
K
G
G
R
F
V
E
G
P
V
S
G
S
K
K
P
A
E
D
G
Q
L
I
I
L
A
A
G
D
K
A
L
F
E
E
S
I
P
A
F
D
V
L
G
K
R
-
S
F
Y
L
G
Q
V
G
N
G
A
K
M
K
L
I
V
N
M
I
M
G
S
M
M
N
A
F
S
E
G
L
V
L
A
D
K
S
G
L
S
S
D
T
L
L
D
I
------------------
L
--
D
L
G
A
M
T
N
P
M
F
-
K
G
K
--
G
P
-------
S
-------
M
N
-----
K
S
S
Y
P
P
A
F
P
L
K
H
Q
Q
K
D
M
R
L
A
L
A
L
G
D
E
N
A
V
S
M
P
V
A
A
A
A
N
E
A
F
K
K
A
R
S
L
G
L
G
D
L
D
F
S
A
V
I
E
A
V
K
F
S
R
-------
3
PsiBlast_PDB
77.23
39%
-123
- C1 -
-
1YB4
-
?
A:
[2-270]
-
K
L
G
F
I
G
L
G
I
M
G
S
P
M
A
I
N
L
A
R
A
G
H
Q
L
H
V
T
T
-
I
G
P
V
A
D
E
L
L
S
L
G
A
V
N
V
E
T
A
R
Q
V
T
E
F
A
D
I
I
F
I
M
V
P
D
T
P
Q
V
E
D
V
L
F
G
-
E
H
G
C
A
K
T
S
L
Q
G
K
T
I
V
D
M
S
S
I
S
P
I
E
T
K
R
F
A
Q
R
V
N
E
M
G
A
D
Y
L
D
A
P
V
S
G
G
E
I
G
A
R
E
G
T
L
S
I
M
V
G
G
E
Q
K
V
F
D
R
V
K
P
L
F
D
I
L
G
K
N
-
I
T
L
V
G
G
N
G
D
G
Q
T
C
K
V
A
N
Q
I
I
V
A
L
N
I
E
A
V
S
E
A
L
V
F
A
S
K
A
G
A
D
P
V
R
V
R
Q
A
------------------
L
--
M
G
G
F
A
S
S
R
I
L
-
E
V
H
--
G
E
-------
R
-------
M
I
-----
N
R
T
F
E
P
G
F
K
I
A
L
H
Q
K
D
L
N
L
A
L
Q
S
A
K
A
L
A
L
N
L
P
N
T
A
T
C
Q
E
L
F
N
T
C
A
A
N
G
------------------------
12
PsiBlast_PDB
76.96
27%
-98
- C1 -
-
3DOJ
-
GLYR1_ARATH
A:
[22-303]
M
E
V
G
F
L
G
L
G
I
M
G
K
A
M
S
M
N
L
L
K
N
G
F
K
V
T
V
W
N
R
T
L
S
K
C
D
E
L
V
E
H
G
A
S
V
C
E
S
P
A
E
V
I
K
K
C
K
Y
T
I
A
M
L
S
D
P
C
A
A
L
S
V
V
F
D
-
K
G
G
V
L
E
Q
I
C
E
G
K
G
Y
I
D
M
S
T
V
D
A
E
T
S
L
K
I
N
E
A
I
T
G
K
G
G
R
F
V
E
G
P
V
S
G
S
K
K
P
A
E
D
G
Q
L
I
I
L
A
A
G
D
K
A
L
F
E
E
S
I
P
A
F
D
V
L
G
K
R
-
S
F
Y
L
G
Q
V
G
N
G
A
K
M
K
L
I
V
N
M
I
M
G
S
M
M
N
A
F
S
E
G
L
V
L
A
D
K
S
G
L
S
S
D
T
L
L
D
I
------------------
L
--
D
L
G
A
M
T
N
P
M
F
-
K
G
K
--
G
P
-------
S
-------
M
N
-----
K
S
S
Y
P
P
A
F
P
L
K
H
Q
Q
K
D
M
R
L
A
L
A
L
G
D
E
N
A
V
S
M
P
V
A
A
A
A
N
E
A
F
K
K
A
R
S
L
G
L
G
D
L
D
F
S
A
V
I
E
-------------
58
HHSearch
76.46
29%
-85
- C1 -
-
2GF2
-
3HIDH_HUMAN
B:
[40-332]
M
P
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
A
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
I
I
T
M
L
P
T
S
I
N
A
I
E
A
Y
S
G
-
A
N
G
I
L
K
K
V
K
K
G
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
-
V
V
Y
C
G
A
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
------------------
L
--
N
M
S
S
G
R
C
W
S
S
-
D
T
Y
NP
V
P
-------
G
-------
V
M
DGVPS
A
N
N
Y
Q
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
T
S
T
K
S
P
I
L
L
G
S
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
Q
F
L
R
E
---------
7
PsiBlast_PDB
76.36
34%
-63
- C1 -
-
5JE8
2
?
A:
[9-291]
-
K
I
G
F
I
G
L
G
N
M
G
L
P
M
S
K
N
L
V
K
S
G
Y
T
V
Y
G
V
D
L
N
K
E
A
E
A
S
F
E
K
E
G
G
I
I
G
L
S
I
S
K
L
A
E
T
C
D
V
V
F
T
S
L
P
S
P
R
A
V
E
A
V
Y
F
G
-
A
E
G
L
F
E
N
G
H
S
N
V
V
F
I
D
T
S
T
V
S
P
Q
L
N
K
Q
L
E
E
A
A
K
E
K
K
V
D
F
L
A
A
P
V
S
G
G
V
I
G
A
E
N
R
T
L
T
F
M
V
G
G
S
K
D
V
Y
E
K
T
E
S
I
M
G
V
L
G
A
N
I
F
H
V
S
E
Q
I
D
S
G
T
T
V
K
L
I
N
N
L
L
I
G
F
Y
T
A
G
V
S
E
A
L
T
L
A
K
K
N
N
M
D
L
D
K
M
F
D
I
------------------
L
N
V
S
Y
G
Q
S
R
I
Y
E
--
R
N
Y
--
K
S
-------
F
-------
I
A
-----
P
E
N
Y
E
P
G
F
T
V
N
L
L
K
K
D
L
G
F
A
V
D
L
A
K
E
S
E
L
H
L
P
V
S
E
M
L
L
N
V
Y
D
E
A
S
Q
A
G
Y
G
E
N
D
M
A
A
L
Y
K
-------------
11
PsiBlast_PDB
76.19
27%
-105
- C1 -
-
3PDU
3
?
A:
[5-284]
---
G
F
L
G
L
G
I
M
G
G
P
M
A
A
N
L
V
R
A
G
F
D
V
T
V
W
N
R
N
P
A
K
C
A
P
L
V
A
L
G
A
R
Q
A
S
S
P
A
E
V
C
A
A
C
D
I
T
I
A
M
L
A
D
P
A
A
A
R
E
V
C
F
G
-
A
N
G
V
L
E
G
I
G
G
G
R
G
Y
I
D
M
S
T
V
D
D
E
T
S
T
A
I
G
A
A
V
T
A
R
G
G
R
F
L
E
A
P
V
S
G
T
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
Q
S
L
F
T
D
A
G
P
A
F
A
A
L
G
K
K
-
C
L
H
L
G
E
V
G
Q
G
A
R
M
K
L
V
V
N
M
I
M
G
Q
M
M
T
A
L
G
E
G
M
A
L
G
R
N
C
G
L
D
G
G
Q
L
L
E
V
------------------
L
--
D
A
G
A
M
A
N
P
M
F
-
K
G
K
--
G
Q
-------
M
-------
L
L
-----
S
G
E
F
P
T
S
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
E
L
G
D
R
L
G
Q
P
L
H
G
A
A
T
A
N
E
S
F
K
R
A
R
A
A
G
H
A
D
E
D
F
A
A
V
F
R
V
------------
9
PsiBlast_PDB
75.80
35%
-95
- C1 -
-
4DLL
-
?
A:
[33-299]
-
K
I
T
F
L
G
T
G
S
M
G
L
P
M
A
R
R
L
C
E
A
G
Y
A
L
Q
V
W
N
R
T
P
A
R
A
A
S
L
A
A
L
G
A
T
I
H
E
Q
A
R
A
A
A
R
D
A
D
I
V
V
S
M
L
E
N
G
A
V
V
Q
D
V
L
F
A
-
Q
-
G
V
A
A
A
M
K
P
G
S
L
F
L
D
M
A
S
I
T
P
R
E
A
R
D
H
A
A
R
L
G
A
L
G
I
A
H
L
D
T
P
V
S
G
G
T
V
G
A
E
Q
G
T
L
V
I
M
A
G
G
K
P
A
D
F
E
R
S
L
P
L
L
K
V
F
G
R
A
--
T
H
V
G
P
H
G
S
G
Q
L
T
K
L
A
N
Q
M
I
V
G
I
T
I
G
A
V
A
E
A
L
L
F
A
T
K
G
G
A
D
M
A
K
V
K
E
A
------------------
I
--
T
G
G
F
A
D
S
R
V
L
-
Q
L
H
--
G
Q
-------
R
-------
M
V
-----
E
R
D
F
A
P
R
A
R
L
S
I
Q
L
K
D
M
R
N
A
L
A
T
A
Q
E
I
G
F
D
A
P
I
T
----
G
L
F
E
Q
L
Y
A
E
G
V
E
H
---------------------
8
PsiBlast_PDB
75.78
34%
-92
- C- -
-
3CKY
-
HMGD_EUBBA
A:
[5-289]
I
K
I
G
F
I
G
L
G
A
M
G
K
P
M
A
I
N
L
L
K
E
G
V
T
V
Y
A
F
D
L
M
E
A
N
V
A
A
V
V
A
Q
G
A
Q
A
C
E
N
N
Q
K
V
A
A
A
S
D
I
I
F
T
S
L
P
N
A
G
I
V
E
T
V
M
N
G
-
P
G
G
V
L
S
A
C
K
A
G
T
V
I
V
D
M
S
S
V
S
P
S
S
T
L
K
M
A
K
V
A
A
E
K
G
I
D
Y
V
D
A
P
V
S
G
G
T
K
G
A
E
A
G
T
L
T
I
M
V
G
A
S
E
A
V
F
E
K
I
Q
P
V
L
S
V
I
G
K
D
-
I
Y
H
V
G
D
T
G
A
G
D
A
V
K
I
V
N
N
L
L
L
G
C
N
M
A
S
L
A
E
A
L
V
L
G
V
K
C
G
L
K
P
E
T
M
Q
E
I
------------------
I
--
G
K
S
S
G
R
S
Y
A
M
E
A
K
M
--
E
K
-------
F
-------
I
M
-----
S
G
D
F
A
G
G
F
A
M
D
L
Q
H
K
D
L
G
L
A
L
E
A
G
K
E
G
N
V
P
L
P
M
T
A
M
A
T
Q
I
F
E
G
G
R
A
M
G
L
G
R
E
D
M
S
A
V
I
K
V
W
-----------
10
PsiBlast_PDB
75.26
29%
-118
- C1 -
-
2UYY
1
GLYR1_HUMAN
A:
[32-296]
-
K
I
G
F
L
G
L
G
L
M
G
S
G
I
V
S
N
L
L
K
M
G
H
T
V
T
V
W
N
R
T
A
E
K
C
D
L
F
I
Q
E
G
A
R
L
G
R
T
P
A
E
V
V
S
T
C
D
I
T
F
A
C
V
S
D
P
K
A
A
K
D
L
V
L
G
-
P
S
G
V
L
Q
G
I
R
P
G
K
C
Y
V
D
M
S
T
V
D
A
D
T
V
T
E
L
A
Q
V
I
V
S
R
G
G
R
F
L
E
A
P
V
S
G
N
Q
Q
L
S
N
D
G
M
L
V
I
L
A
A
G
D
R
G
L
Y
E
D
C
S
S
C
F
Q
A
M
G
K
T
-
S
F
F
L
G
E
V
G
N
A
A
K
M
M
L
I
V
N
M
V
Q
G
S
F
M
A
T
I
A
E
G
L
T
L
A
Q
V
T
G
Q
S
Q
Q
T
L
L
D
I
------------------
L
--
N
Q
G
Q
L
A
S
I
F
L
-
D
Q
K
--
C
Q
-------
N
-------
I
L
-----
Q
G
N
F
K
P
D
F
Y
L
K
Y
I
Q
K
D
L
R
L
A
I
A
L
G
D
A
V
N
H
P
T
P
M
A
A
A
A
N
E
V
Y
K
R
-----------------------------
17
PsiBlast_PDB
68.82
31%
-115
- C1 -
-
3OBB
2
SERDH_PSEAE
A:
[5-252]
-
Q
I
A
F
I
G
L
G
H
M
G
A
P
M
A
T
N
L
L
K
A
G
Y
L
L
N
V
F
D
L
V
Q
S
A
V
D
G
L
V
A
A
G
A
S
A
A
R
S
A
R
D
A
V
Q
G
A
D
V
V
I
S
M
L
P
A
S
Q
H
V
E
G
L
Y
L
D
-
D
D
G
L
L
A
H
I
A
P
-
T
L
V
L
E
C
S
T
I
A
P
T
S
A
R
K
I
H
A
A
A
R
E
R
G
L
A
M
L
D
A
P
V
S
G
G
T
A
G
A
A
A
G
T
L
T
F
M
V
G
G
D
A
E
A
L
E
K
A
R
P
L
F
E
A
M
G
R
N
-
I
F
H
A
G
P
D
G
A
G
Q
V
A
K
V
C
N
N
Q
L
L
A
V
L
M
I
G
T
A
E
A
M
A
L
G
V
A
N
G
L
E
A
K
V
L
A
E
I
------------------
M
--
R
R
S
S
G
G
N
W
A
L
-
E
V
Y
--
N
P
WPGVMEN
A
-------
P
A
-----
S
R
D
Y
S
G
G
F
M
A
Q
L
M
A
K
D
L
G
L
-----------------------------------------------------
24
PsiBlast_CBE
68.25
33%
-88
- C1 -
-
5U5G
3
?
D:
[5-236]
--
V
G
F
I
G
L
G
R
M
G
Q
A
I
C
R
R
L
L
A
S
Q
M
P
V
H
V
H
N
R
S
R
E
K
A
D
D
L
I
R
Q
G
A
V
W
A
P
D
I
V
A
L
T
R
A
A
R
V
L
F
V
C
T
A
G
S
E
A
V
Q
D
F
Y
H
A
P
D
R
G
L
L
A
C
L
E
V
G
D
I
V
V
D
L
S
T
I
A
P
E
T
A
E
G
L
H
A
A
F
A
Q
Q
G
A
D
Y
I
E
C
P
V
S
G
G
V
E
G
A
L
A
G
I
L
S
A
I
V
S
G
R
P
E
A
Y
G
L
I
R
P
L
L
E
V
F
C
A
T
-
V
T
Y
V
P
E
P
G
K
A
Q
R
L
K
I
L
N
N
L
A
E
S
I
N
L
A
G
A
I
E
V
I
S
Q
G
L
S
Q
G
L
D
L
K
S
M
A
D
V
FTSCRGRSAYMDVALGYA
L
--
S
G
G
A
S
S
N
V
S
L
------------------------------------------------------------------------------------------------------