@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y298: (2018-01-29 )
MERTAIVIQDLSAAYQGKTVLKTINLTINPQKITGIIGPNGAGKSTFMKSLLELIPATTGKVTFSGQSVNSVRKKIAYVEQRSELDLSFPIDVLGVVLLGTYPSLRIGQRPGKKEKERARQALKKVGMEEYAKRQISELSGGQLQRVFIARALAQGAEWIFLDEPFVGIDALSERKIFDILQELKNSGKTILIVHHDLHKVEEYFDEVILLNKQLIASGPVQEVFTSKNLQLAYGEIIRHLVKGGEKK
Atome Classification :
(24 SA)
.........10........20-........30........40........50........60.....-------...----70-----.-------.---------...-----.-----...80----....-....90------.-........100.......110.......120.......130......-..140.......150...------....160.......170.......180..-...-..190.......200.......210.-.-...-.-..220..---.....230..-.....240......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
ME
R
T
A
I
V
I
Q
D
L
S
A
A
YQG
K
T
V
L
-
K
T
I
N
L
T
I
N
P
Q
K
I
T
G
I
IGPNGA
G
K
S
T
F
M
K
S
L
L
E
LIPATT
G
K
V
T
FSG-------Q
S
V
----
N
------
S
-------
V
---------
R
K
K
-----
I
-----
A
Y
V
E
Q
----RSEL-DLSF
P
-------
I
-
D
V
L
G
V
V
L
LGTYPSLRIGQRPG
K
K
E
K
E
R
A
R
Q
A
L
K
KV
G
M
E
E
-
Y
A
K
R
Q
I
S
-ELSGG
Q
L
Q
R
V
F
I
A
R
A
L
AQ------GA
E
W
I
F
LDEPFV
G
I
D
A
LSER
K
I
F
D
I
L
Q
E
L
-
K
NS-G
K
T
I
L
I
V
HH
D
L
H
K
V
E
E
Y
F
D
E
V
I
L
L
-
N
-
K
-
Q
LI-A-SG
P
V
Q
E
V
---FTSKN
L
Q
L
A
Y
-
G
E
I
I
R
H
L
V
KGGEKK
56
PsiBlast_CBE
82.15
31%
-41
- C1 -
-
1B0U
1
HISP_SALTY
A:
[5-241]
---
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
H
E
V
L
-
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
-------
Q
N
I
----
N
------
L
-------
V
---------
R
D
K
DGQLK
V
-----
A
D
K
N
Q
L
R
L
L
R
T
R
L
-
T
M
V
F
Q
HFNLWSH
M
-
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
G
L
S
K
H
D
A
R
---
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
-
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
------
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
-
A
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
-
H
-
Q
-
G
K
I
E
E
-
E
G
D
P
E
Q
V
---
F
------------------------
1
PsiBlast_PDB
81.72
32%
-26
- C1 -
-
4U00
1
?
A:
[5-227]
-----
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
-
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
-------
L
S
V
----
K
------
D
DRA
L
R
E
-
I
---------
R
R
E
-----
V
-----
G
M
V
F
Q
----
Q
F
N
L
----
F
P
H------
M
-
T
V
L
E
N
V
---
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
-
Q
A
R
K
Y
P
A
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
G
G
-
Q
I
V
-
E
-
E
G
R
P
E
E
I
---
F
T
-----------------------
2
PsiBlast_PDB
80.97
32%
-32
- C1 -
-
4U02
-
?
A:
[5-227]
-----
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
-
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
-------
L
S
V
----
K
------
D
DRA
L
R
E
-
I
---------
R
R
E
-----
V
-----
G
M
V
F
Q
----
Q
F
N
L
----
F
P
H------
M
-
T
V
L
E
N
V
---
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
-
Q
A
R
K
Y
P
A
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
G
G
-
Q
I
V
-
E
-
E
G
R
P
E
E
I
---
F
T
-----------------------
8
PsiBlast_PDB
78.98
31%
-15
- C1 -
-
1VPL
-
?
A:
[15-251]
----
A
V
V
V
K
D
L
R
K
R
I
G
K
K
E
I
L
-
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
T
V
F
G
-------
K
N
V
VEE
P
H
------
E
-------
V
---------
R
K
L
-----
I
-----
S
Y
L
P
E
----
E
A
G
A
-
Y
R
N
M
Q
G
------
I
-
E
Y
L
R
F
V
A
-
G
F
Y
A
S
------
S
S
S
E
I
E
E
M
V
E
R
A
T
E
I
A
G
L
G
E
-
K
I
K
D
R
V
S
-
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
------
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
K
Q
A
-
S
Q
E
-
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
-
G
-
T
I
V
-
E
-
T
G
T
V
E
E
L
K
E
R
Y
K
A
Q
N
I
E
E
V
F
-
E
E
V
V
K
---------
4
PsiBlast_PDB
78.44
31%
-34
- C1 -
-
4G1U
-
HMUV_YERPE
C:
[22-245]
---------------
Q
Q
Q
A
L
I
-
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
H
G
E
C
H
L
L
G
-------
Q
N
L
----
N
------
S
-------
W
---------
Q
P
K
-----
A
L
A
R
T
R
A
V
M
R
Q
----
Y
S
E
---
L
A
F
P
-------
F
-
S
V
S
E
V
I
Q
M
G
R
A
P
Y
------
G
G
S
Q
D
R
Q
A
L
Q
Q
V
M
A
Q
T
D
C
L
A
-
L
A
Q
R
D
Y
R
-
V
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
L
WQPQP
T
P
R
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
L
T
R
Q
E
-
P
L
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
M
L
L
-
A
-
Q
G
K
L
V
-
A
-
C
G
T
P
E
E
V
---
L
N
A
E
T
L
T
Q
W
Y
---------------
32
PsiBlast_CBE
76.05
31%
-39
- C1 -
-
2OLK
2
?
B:
[25-247]
-----
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKAKD
T
N
L
----
N
------
K
-------
V
---------
R
E
E
-----
V
-----
G
M
V
F
Q
----
R
F
N
L
----
F
P
H------
M
-
T
V
L
N
N
I
---
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
-
Y
I
I
-
E
-
E
G
K
P
E
D
L
---
F
------------------------
15
PsiBlast_PDB
75.12
29%
-38
- C1 -
-
4P31
1
LPTB_ECOLI
A:
[3-234]
-----
L
T
A
K
N
L
A
K
A
Y
K
G
R
R
V
V
-
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
-------
D
D
I
----
S
LLP
L
H
A
R
-------
A
---------
R
R
G
-----
I
-----
G
Y
L
P
Q
----
E
A
S
I
-
F
R
R
L
S
-------
V
Y
D
N
L
M
A
V
L
-
Q
I
R
D
D
L
S
A
E
Q
R
-----
E
D
R
A
N
E
L
M
E
E
F
H
I
E
H
-
L
R
D
S
M
G
Q
-
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
------
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
-
R
D
S
-
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
-
S
-
Q
G
H
L
I
-
A
-
H
G
T
P
T
E
I
---
L
Q
D
E
H
V
K
R
V
Y
L--------------
13
PsiBlast_PDB
74.34
31%
-36
- C1 -
-
3C4J
2
?
A:
[25-247]
-----
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKAKD
T
N
L
----
N
------
K
-------
V
---------
R
E
E
-----
V
-----
G
M
V
F
Q
----
R
F
N
L
----
F
P
H------
M
-
T
V
L
N
N
I
---
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
-
Y
I
I
-
E
-
E
G
K
P
E
D
L
---
F
------------------------
10
PsiBlast_PDB
74.30
31%
-39
- C1 -
-
2OLK
1
?
A:
[25-247]
-----
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKAK
D
T
N
L
----
N
------
K
-------
V
---------
R
E
E
-----
V
-----
G
M
V
F
Q
----
R
F
N
L
----
F
P
H------
M
-
T
V
L
N
N
I
---
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
-
Y
I
I
-
E
-
E
G
K
P
E
D
L
---
F
------------------------
31
PsiBlast_CBE
74.29
31%
-39
- C1 -
-
2OLK
1
?
C:
[25-247]
-----
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKAKD
T
N
L
----
N
------
K
-------
V
---------
R
E
E
-----
V
-----
G
M
V
F
Q
----
R
F
N
L
----
F
P
H------
M
-
T
V
L
N
N
I
---
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
-
Y
I
I
-
E
-
E
G
K
P
E
D
L
---
F
------------------------
25
PsiBlast_CBE
73.91
31%
-33
- C1 -
-
3C4J
2
?
B:
[25-247]
-----
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKAKD
T
N
L
----
N
------
K
-------
V
---------
R
E
E
-----
V
-----
G
M
V
F
Q
----
R
F
N
L
----
F
P
H------
M
-
T
V
L
N
N
I
---
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
-
Y
I
I
-
E
-
E
G
K
P
E
D
L
---
F
------------------------
30
PsiBlast_CBE
73.59
31%
-33
- C1 -
-
2OLK
1
?
D:
[25-247]
-----
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKAKD
T
N
L
----
N
------
K
-------
V
---------
R
E
E
-----
V
-----
G
M
V
F
Q
----
R
F
N
L
----
F
P
H------
M
-
T
V
L
N
N
I
---
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
-
Y
I
I
-
E
-
E
G
K
P
E
D
L
---
F
------------------------
9
PsiBlast_PDB
73.23
31%
-41
- C1 -
-
2OLJ
3
?
A:
[25-247]
-----
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKAKD
T
N
L
----
N
------
K
-------
V
---------
R
E
E
-----
V
-----
G
M
V
F
Q
----
R
F
N
L
----
F
P
H------
M
-
T
V
L
N
N
I
---
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
-
Y
I
I
-
E
-
E
G
K
P
E
D
L
---
F
------------------------
11
PsiBlast_PDB
72.63
31%
-39
- C1 -
-
2OUK
-
?
A:
[25-247]
-----
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKAKD
T
N
L
----
N
------
K
-------
V
---------
R
E
E
-----
V
-----
G
M
V
F
Q
----
R
F
N
L
----
F
P
H------
M
-
T
V
L
N
N
I
---
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
-
Y
I
I
-
E
-
E
G
K
P
E
D
L
---
F
------------------------
12
PsiBlast_PDB
71.29
31%
-37
- C1 -
-
2Q0H
3
?
A:
[25-247]
-----
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKAKD
T
N
L
----
N
------
K
-------
V
---------
R
E
E
-----
V
-----
G
M
V
F
Q
----
R
F
N
L
----
F
P
H------
M
-
T
V
L
N
N
I
---
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
-
Y
I
I
-
E
-
E
G
K
P
E
D
L
---
F
------------------------
35
PsiBlast_CBE
70.94
31%
-32
- C1 -
-
4YMV
1
?
A:
[2-224]
-----
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
-
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-------
V
K
I
----
N
------
N
GKVN
I
N
K
V
---------
R
Q
K
-----
V
-----
G
M
V
F
Q
----
H
F
N
L
----
F
P
-------
H
---
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
------
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
-
D
-
G
V
I
-
V
E
E
G
T
P
E
E
I
---
F
------------------------
26
PsiBlast_CBE
70.63
31%
-44
- C1 -
-
2Q0H
3
?
B:
[25-247]
-----
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKAKD
T
N
L
----
N
------
K
-------
V
---------
R
E
E
-----
V
-----
G
M
V
F
Q
----
R
F
N
L
----
F
P
H------
M
-
T
V
L
N
N
I
---
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
-
Y
I
I
-
E
-
E
G
K
P
E
D
L
---
F
------------------------
7
PsiBlast_PDB
70.60
30%
-6
- C1 -
-
2NQ2
-
Y1470_HAEIN
C:
[4-221]
----
A
L
S
V
E
N
L
G
F
Y
Y
Q
A
E
N
F
L
F
Q
Q
L
N
F
D
L
N
K
G
D
I
L
A
V
L
G
Q
N
G
C
G
K
S
T
L
L
D
L
L
L
G
I
H
R
P
I
Q
G
K
I
-------------------------
E
-------
V
---------
Y
Q
S
-----
I
-----
G
F
V
P
Q
----
F
--
F
-
S
S
P
F
A
-------
Y
-
S
V
L
D
I
V
L
M
G
R
S
T
H
I
N
T
F
A
K
P
K
S
H
D
Y
Q
V
A
M
Q
A
L
D
Y
L
N
L
T
H
-
L
A
K
R
E
F
T
-
S
L
S
G
G
Q
R
Q
L
I
L
I
A
R
A
I
A
S
------
E
C
K
L
I
L
L
D
E
P
T
S
A
L
D
L
A
N
Q
D
I
V
L
S
L
L
I
D
L
-
A
Q
S
Q
N
M
T
V
V
F
T
T
H
Q
P
N
Q
V
V
A
I
A
N
K
T
L
L
L
-
N
-
K
-
Q
N
F
-
K
-
F
G
E
T
R
N
I
---
L
T
S
E
N
L
-------------------
17
PsiBlast_PDB
70.30
31%
-33
- C1 -
-
4YMS
-
?
J:
[2-224]
-----
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
-
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
-------
V
K
I
----
N
------
N
GKVNINK
V
---------
R
Q
K
-----
V
-----
G
M
V
F
Q
----
H
F
N
L
----
F
P
-------
H
---
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
------
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
-
D
-
G
V
I
-
V
E
E
G
T
P
E
E
I
---
F
------------------------
34
PsiBlast_CBE
70.22
31%
-39
- C1 -
-
3C41
2
?
K:
[4-226]
-----
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
INLKAKD
T
N
L
----
N
------
K
-------
V
---------
R
E
E
-----
V
-----
G
M
V
F
Q
----
R
F
N
L
----
F
P
H------
M
-
T
V
L
N
N
I
---
T
L
A
P
M
K
V
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
-
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
-
Y
I
I
-
E
-
E
G
K
P
E
D
L
---
F
------------------------
51
PsiBlast_CBE
58.29
33%
10
- C1 -
-
3TIF
4
Y796_METJA
A:
[21-218]
--------------------
L
-
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------
I
K
T
----
N
------
D
-------
L
D
D
D
E
L
T
K
I
R
R
D
K
-----
I
-----
G
F
V
F
Q
----
Q
F
N
L
I
P
L
L
T
A
-------
L
-
E
N
V
E
L
P
L
I
F
K
Y
R
----
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
-
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
----------------------------------------------
50
PsiBlast_CBE
57.34
33%
8
- C1 -
-
3TIF
3
Y796_METJA
B:
[21-218]
--------------------
L
-
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------
I
K
T
----
N
------
D
-------
L
DDDELTKIR
R
D
K
-----
I
-----
G
F
V
F
Q
----
Q
F
N
L
I
P
L
L
T
A
-------
L
-
E
N
V
E
L
P
L
I
F
K
Y
R
----
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
-
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
----------------------------------------------
52
PsiBlast_CBE
53.45
33%
12
- C1 -
-
1L2T
3
Y796_METJA
B:
[21-218]
--------------------
L
-
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------
I
K
T
----
N
------
D
-------
L
DDDELTKIR
R
D
K
-----
I
-----
G
F
V
F
Q
----
Q
F
N
L
I
P
L
L
T
A
-------
L
-
E
N
V
E
L
P
L
I
F
K
Y
R
----
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
-
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
----------------------------------------------
53
PsiBlast_CBE
52.93
33%
14
- C1 -
-
1L2T
3
Y796_METJA
A:
[21-218]
--------------------
L
-
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------
I
K
T
----
N
------
D
-------
L
D
D
D
E
L
T
K
I
R
R
D
K
-----
I
-----
G
F
V
F
Q
----
Q
F
N
L
I
P
L
L
T
A
-------
L
-
E
N
V
E
L
P
L
I
F
K
Y
R
----
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
-
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
-
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
----------------------------------------------