@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y365: (2018-02-03 )
MRIPHFHNKIIIFSVLINVKDTRRVGKNQTKNIFVKSIYKKIFLYNEGIRNGGAIMEIGVIGLGKMGLNLALNLKEHHHKVQGLDISSTAVSQARENDIPAYQEISEFLATFEQKKIIWLMLPAGEITENMLRKLFPKLGPGDIIIEGGNSYYKDSIRRAEEFQKNEIGYLDCGTSGGIEGARHQACLMIGGDKETFLSVEQLFKDVAIERGYLYAGASGSGHFLKMIHNGIEYGMMQAIGEGFQLVQKSEYAFDLEQVARVWNHGSVIRGWLMEIMEDQLNEHPNLSNYRGIVSASGEAKWTVETALEMAVPVPVIATSLFMRNLSQEEDSFSAKVVSALRNGFGGHEIVEKGE
Atome Classification :
(28 SA)
.........10........20........30........40........50........60........70........80----......----..90-----...----...---.--.--100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......-----210---.------.------.-------......220.......230.......240.......--250.-......260---.---..--....270....------...---280..---.--.------.-.-.290...-----.---....---300.-.......310.......320.....--..330.-.--.--......340......--.350...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRIPHFHN
K
I
I
I
F
S
V
L
IN
V
K
D
T
R
RVGKNQ
T
K
N
I
F
V
K
S
I
Y
K
K
I
F
L
YNEGIRNG
G
A
I
M
E
I
G
V
I
GLGKMG
L
N
L
A
L
N
L
K
E
HHHKV----Q
G
L
DI
S
----
S
T
A
V
-----
S
Q
A----REN---D--I--
P
A
Y
Q
E
I
S
E
F
L
A
T
FEQK
K
I
I
W
L
ML
P
A
G
E
I
T
E
N
M
L
R
K
L
F
PKLGPG
D
I
I
I
EGGN
S
Y
Y
K
D
S
I
R
R
A
E
E
F
QKNE
I
G
Y
L
DCGTSGGIEGAR
H
Q
A
C
L
M
IGGD
K
E
T
F
L
S
V
E
Q
L
F
K
D
V
A
I-----E-----R------
G
------
Y
-------
L
Y
AGASGS
G
H
F
L
K
M
I
H
N
G
I
E
Y
G
M
M
Q
A
I
G
E
G
F
Q
L
V
Q
K--S
E
Y
A-F
D
L
E
Q
V
A
R
V
---W---NH--
G
S
V
I
R
G
W
L
M
E
I
------
M
E
D
---
Q
L
NEH---P--N------L-S-NY-
R
G
I
V
-----S---ASGE---
A
K
-
W
-
T
V
E
T
A
L
E
MAVP
V
P
V
I
A
T
S
L
F
M
R
NLS--QEE--D-
S
--
F
--
S
A
K
V
V
S
A
L
R
NGFGGH--EIVEKGE
61
HHSearch
82.04
33%
0
- C- -
-
4GWG
2
6PGD_HUMAN
A:
[3-309]
-----------------------------------------------------
A
Q
A
D
I
A
L
I
G
L
A
V
M
G
Q
N
L
I
L
N
M
N
D
H
G
F
V
V
----
C
A
F
N
R
T
----
V
S
K
V
-----
D
D
F
----
L
A
N
EAK
G
--
T
K
V
V
G
A
Q
S
L
K
E
M
V
S
K
L
K
K
P
R
R
I
I
L
L
V
K
A
G
Q
A
V
D
D
F
I
E
K
L
V
P
L
L
D
T
G
D
I
I
I
D
G
G
N
S
E
Y
R
D
T
T
R
R
C
R
D
L
K
A
K
G
I
L
F
V
G
S
G
V
S
G
G
E
E
G
A
R
Y
G
P
S
L
M
P
G
G
N
K
E
A
W
P
H
I
K
T
I
F
Q
G
I
A
A
------------------
K
------
V
GTGEPCC
D
W
V
G
D
E
G
A
G
H
F
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
C
E
A
Y
H
L
M
K
D
V-
L
--
G
-
M
A
Q
D
E
M
A
Q
A
---
F
---
E
D
W
N
K
T
E
L
D
S
F
L
I
E
I
------
T
A
N
---
I
L
K
F
Q
---
D
--
T
------
D
G
K
H
L
L
-
P
K
I
R
-----
D
SA-
G
Q
K
G
---
T
G
K
W
-
T
A
I
S
A
L
E
Y
G
V
P
V
T
L
I
G
E
A
V
F
A
R
C
L
S
--
S
L
K
D
E
R
-
I
--
Q
--
A
S
K
K
L
K
G
-----------------
8
PsiBlast_PDB
76.75
33%
-4
- C4 -
-
2ZYD
-
6PGD_ECOLI
A:
[17-332]
--------------------------------------------------------
Q
I
G
V
V
G
M
A
V
M
G
R
N
L
A
L
N
I
E
S
R
G
Y
T
V
S
I
F
N
R
S
R
E
K
T
----
E
E
V
I
-----
A
E
N
----
P
G
K
---
K
--
L
--
V
P
Y
Y
T
V
K
E
F
V
E
S
L
E
T
P
R
R
I
L
L
M
V
K
A
G
A
G
T
D
A
A
I
D
S
L
K
P
Y
L
D
K
G
D
I
I
I
D
G
G
N
T
F
F
Q
D
T
I
R
R
N
R
E
L
S
A
E
G
F
N
F
I
G
T
G
V
S
G
G
E
E
G
A
L
K
G
P
S
I
M
P
G
G
Q
K
E
A
Y
E
L
V
A
P
I
L
T
K
I
A
A
V
A
EDG
E
-----
P
------
C
------
V
-------
T
Y
I
G
A
D
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
A
Y
S
L
L
-
K
--
G
G
L
N
-
L
T
N
E
E
L
A
Q
T
F
T
E
W
---
N
N
--
G
E
-
L
S
S
Y
L
I
D
I
------
T
K
D
---
I
F
T
K
K
---
D
--
E
------
D
-
G
-
N
Y
-
L
V
D
V
ILD
E
A
A
---
N
K
G
T
---
G
K
-
W
-
T
S
Q
S
A
L
D
L
G
E
P
L
S
L
I
T
E
S
V
F
A
R
Y
I
S
--
S
L
K
--
D
-
Q
R
V
A
--
A
S
K
V
L
S
G
P
Q
A
Q
P
A
G
D
K
A
E
F
I
E
K
--
10
PsiBlast_PDB
76.31
33%
-7
- C4 -
-
2ZYG
-
?
A:
[5-320]
--------------------------------------------------------
Q
I
G
V
V
G
M
A
V
M
G
R
N
L
A
L
N
I
E
S
R
G
Y
T
V
----
S
V
F
N
R
S
R
E
K
T
E
E
V
I
-----
A
E
N
----
P
G
K
---
K
--
L
--
V
P
Y
Y
T
V
Q
E
F
V
E
S
L
E
T
P
R
R
I
L
L
M
V
K
A
G
A
G
T
D
S
A
I
D
S
L
K
P
Y
L
D
K
G
D
I
I
I
D
G
G
N
T
F
F
Q
D
T
I
R
R
N
R
E
L
S
A
E
G
F
N
F
I
G
T
G
V
S
G
G
E
E
G
T
L
K
G
P
S
I
M
P
G
G
Q
K
E
A
Y
E
L
V
A
P
I
L
K
Q
I
A
A
VAEDG
E
-----
P
------
C
------
V
-------
T
Y
I
G
A
D
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
A
Y
A
L
L
-
K
--
G
G
L
A
-
L
S
N
E
E
L
A
Q
T
F
T
E
W
---
N
E
--
G
E
-
L
S
S
Y
L
I
D
I
------
T
K
D
---
I
F
T
K
K
---
D
--
E
------
E
-
G
-
K
Y
-
L
V
D
V
ILD
E
A
A
---
N
K
G
T
---
G
K
-
W
-
T
S
Q
S
S
L
D
L
G
E
P
L
S
L
I
T
E
S
V
F
A
R
Y
I
S
--
S
L
K
--
D
-
Q
R
V
A
--
A
S
K
V
L
S
G
P
Q
A
Q
P
A
G
D
K
A
E
F
I
E
K
--
7
PsiBlast_PDB
76.25
33%
-0
- C4 -
-
2ZYA
1
6PGD_ECOLI
A:
[17-332]
--------------------------------------------------------
Q
I
G
V
V
G
M
A
V
M
G
R
N
L
A
L
N
I
E
S
R
G
Y
T
V
S
I
F
N
R
S
R
E
K
T
----
E
E
V
I
-----
A
E
N
----
P
G
K
---
K
--
L
--
V
P
Y
Y
T
V
K
E
F
V
E
S
L
E
T
P
R
R
I
L
L
M
V
K
A
G
A
G
T
D
A
A
I
D
S
L
K
P
Y
L
D
K
G
D
I
I
I
D
G
G
N
T
F
F
Q
D
T
I
R
R
N
R
E
L
S
A
E
G
F
N
F
I
G
T
G
V
S
G
G
E
E
G
A
L
K
G
P
S
I
M
P
G
G
Q
K
E
A
Y
E
L
V
A
P
I
L
T
K
I
A
A
V
A
EDG
E
-----
P
------
C
------
V
-------
T
Y
I
G
A
D
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
A
Y
S
L
L
-
K
--
G
G
L
N
-
L
T
N
E
E
L
A
Q
T
F
T
E
W
---
N
N
--
G
E
-
L
S
S
Y
L
I
D
I
------
T
K
D
---
I
F
T
K
K
---
D
--
E
------
D
-
G
-
N
Y
-
L
V
D
V
ILD
E
A
A
---
N
K
G
T
---
G
K
-
W
-
T
S
Q
S
A
L
D
L
G
E
P
L
S
L
I
T
E
S
V
F
A
R
Y
I
S
--
S
L
K
--
D
-
Q
R
V
A
--
A
S
K
V
L
S
G
P
Q
A
Q
P
A
G
D
K
A
E
F
I
E
K
--
48
HHSearch
75.94
33%
-12
- C4 -
-
2ZYD
-
6PGD_ECOLI
A:
[15-320]
------------------------------------------------------
K
Q
Q
I
G
V
V
G
M
A
V
M
G
R
N
L
A
L
N
I
E
S
R
G
Y
T
V
----
S
I
F
N
R
S
----
R
E
K
T
-----
E
E
V
----
I
A
E
N
P-
G
KK
L
--
V
P
Y
Y
T
V
K
E
F
V
E
S
L
E
T
P
R
R
I
L
L
M
V
K
A
G
A
G
T
D
A
A
I
D
S
L
K
P
Y
L
D
K
G
D
I
I
I
D
G
G
N
T
F
F
Q
D
T
I
R
R
N
R
E
L
S
A
E
G
F
N
F
I
G
T
G
V
S
G
G
E
E
G
A
L
K
G
P
S
I
M
P
G
G
Q
K
E
A
Y
E
L
V
A
P
I
L
T
K
I
A
A
-----
V
A
EDGE
P
------
C
------
V
-------
T
Y
I
G
A
D
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
A
Y
S
L
L
K
G
G
-
L
--
N
-
L
T
N
E
E
L
A
Q
T
---
F
---
T
E
W
N
N
G
E
L
S
S
Y
L
I
D
I
------
T
K
D
---
I
F
T
K
K
DED
G
--
N
------
Y
---
L
V
-
D
V
I
L
-----
D
E
A
A
N
K
G
T
---
G
K
-
W
-
T
S
Q
S
A
L
D
L
G
E
P
L
S
L
I
T
E
S
V
F
A
R
Y
I
S
--
S
L
K
D
-
Q
R
V
--
A
--
A
S
K
V
L
S
G
P
Q
A
--------------
5
PsiBlast_PDB
74.29
31%
-5
- C4 -
-
2IZ0
6
6PGD_LACLM
A:
[8-324]
---------------------------------------------------------
F
G
V
V
G
M
A
V
M
G
K
N
L
A
L
N
V
E
S
R
G
Y
T
V
----
A
I
Y
N
R
T
----
T
S
K
T
-----
E
E
V
F
K
E
H
Q
D
K
---
N
--
L
--
V
F
T
K
T
L
E
E
F
V
G
S
L
E
K
P
R
R
I
M
L
M
V
Q
A
G
A
A
T
D
A
T
I
K
S
L
L
P
L
L
D
I
G
D
I
L
I
D
G
G
N
T
H
F
P
D
T
M
R
R
N
A
E
L
A
D
S
G
I
N
F
I
G
T
G
V
S
G
G
E
K
G
A
L
L
G
P
S
M
M
P
G
G
Q
K
E
A
Y
D
L
V
A
P
I
F
E
Q
I
A
A
-----
K
-----
A
------
P
QDGKPC
V
-------
A
Y
M
G
A
N
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
S
Y
D
L
L
K
R
IL
G
L
S
N
-
A
E
I
Q
A
I
F
E
E
---
W
---
N
E
--
G
E
-
L
D
S
Y
L
I
E
I
------
T
K
E
---
V
L
K
R
K
---
D
--
D
EGEGYI
V
-
D
-
K
I
-
L
D
K
A
-----
G
---
N
K
G
T
---
G
K
-
W
-
T
S
E
S
A
L
D
L
G
V
P
L
P
L
I
T
E
S
V
F
A
R
Y
I
S
T
Y
K
D
E
--
R
-
V
--
K
--
A
S
K
V
L
S
G
P
A
L
D
F
S
G
D
K
K
E
V
I
E
K
--
30
PsiBlast_CBE
74.23
33%
-1
- C4 -
-
2ZYA
1
6PGD_ECOLI
B:
[17-332]
--------------------------------------------------------
Q
I
G
V
V
G
M
A
V
M
G
R
N
L
A
L
N
I
E
S
R
G
Y
T
V
SIFN
R
S
R
E
K
T
----
E
E
V
I
-----
A
E
N
----
P
G
K
---
K
--
L
--
V
P
Y
Y
T
V
K
E
F
V
E
S
L
E
T
P
R
R
I
L
L
M
V
K
A
G
A
G
T
D
A
A
I
D
S
L
K
P
Y
L
D
K
G
D
I
I
I
D
G
G
N
T
F
F
Q
D
T
I
R
R
N
R
E
L
S
A
E
G
F
N
F
I
G
T
G
V
S
G
G
E
E
G
A
L
K
G
P
S
I
M
P
G
G
Q
K
E
A
Y
E
L
V
A
P
I
L
T
K
I
A
A
VAEDG
E
-----
P
------
C
------
V
-------
T
Y
I
G
A
D
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
A
Y
S
L
L
-
K
--
G
G
L
N
-
L
T
N
E
E
L
A
Q
T
FTE
W
---
N
N
--
G
E
-
L
S
S
Y
L
I
D
I
------
T
K
D
---
I
F
T
K
K
---
D
--
E
------
D
-
G
-
N
Y
-
L
V
D
V
ILDEA
A
---
N
K
G
T
---
G
K
-
W
-
T
S
Q
S
A
L
D
L
G
E
P
L
S
L
I
T
E
S
V
F
A
R
Y
I
S
--
S
L
K
--
D
-
Q
RV
A
--
A
S
K
V
L
S
G
P
Q
A
Q
P
A
G
D
KA
E
F
I
E
K
--
9
PsiBlast_PDB
73.54
33%
-0
- C4 -
-
3FWN
1
6PGD_ECOLI
A:
[17-332]
--------------------------------------------------------
Q
I
G
V
V
G
M
A
V
M
G
R
N
L
A
L
N
I
E
S
R
G
Y
T
V
S
I
F
N
R
S
R
E
K
T
----
E
E
V
I
-----
A
E
N
----
P
G
K
---
K
--
L
--
V
P
Y
Y
T
V
K
E
F
V
E
S
L
E
T
P
R
R
I
L
L
M
V
K
A
G
A
G
T
D
A
A
I
D
S
L
K
P
Y
L
D
K
G
D
I
I
I
D
G
G
N
T
F
F
Q
D
T
I
R
R
N
R
E
L
S
A
E
G
F
N
F
I
G
T
G
V
S
G
G
E
E
G
A
L
K
G
P
S
I
M
P
G
G
Q
K
E
A
Y
E
L
V
A
P
I
L
T
K
I
A
A
V
A
EDG
E
-----
P
------
C
------
V
-------
T
Y
I
G
A
D
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
A
Y
S
L
L
-
K
--
G
G
L
N
-
L
T
N
E
E
L
A
Q
T
F
T
E
W
---
N
N
--
G
E
-
L
S
S
Y
L
I
D
I
------
T
K
D
---
I
F
T
K
K
---
D
--
E
------
D
-
G
-
N
Y
-
L
V
D
V
ILD
E
A
A
---
N
K
G
T
---
G
K
-
W
-
T
S
Q
S
A
L
D
L
G
E
P
L
S
L
I
T
E
S
V
F
A
R
Y
I
S
--
S
L
K
--
D
-
Q
R
V
A
--
A
S
K
V
L
S
G
P
Q
A
Q
P
A
G
D
K
A
E
F
I
E
K
--
6
PsiBlast_PDB
73.33
31%
-1
- C4 -
-
2IZ1
4
6PGD_LACLM
A:
[8-324]
---------------------------------------------------------
F
G
V
V
G
M
A
V
M
G
K
N
L
A
L
N
V
E
S
R
G
Y
T
V
----
A
I
Y
N
R
T
----
T
S
K
T
-----
E
E
V
F
K
E
H
Q
D
K
---
N
--
L
--
V
F
T
K
T
L
E
E
F
V
G
S
L
E
K
P
R
R
I
M
L
M
V
Q
A
G
A
A
T
D
A
T
I
K
S
L
L
P
L
L
D
I
G
D
I
L
I
D
G
G
N
T
H
F
P
D
T
M
R
R
N
A
E
L
A
D
S
G
I
N
F
I
G
T
G
V
S
G
G
E
K
G
A
L
L
G
P
S
M
M
P
G
G
Q
K
E
A
Y
D
L
V
A
P
I
F
E
Q
I
A
A
-----
K
-----
A
------
P
QDGKPC
V
-------
A
Y
M
G
A
N
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
S
Y
D
L
L
K
R
IL
G
L
S
N
-
A
E
I
Q
A
I
F
E
E
---
W
---
N
E
--
G
E
-
L
D
S
Y
L
I
E
I
------
T
K
E
---
V
L
K
R
K
---
D
--
D
EGEGYI
V
-
D
-
K
I
-
L
D
K
A
-----
G
---
N
K
G
T
---
G
K
-
W
-
T
S
E
S
A
L
D
L
G
V
P
L
P
L
I
T
E
S
V
F
A
R
Y
I
S
T
Y
K
D
E
--
R
-
V
--
K
--
A
S
K
V
L
S
G
P
A
L
D
F
S
G
D
K
K
E
V
I
E
K
--
29
PsiBlast_CBE
73.25
33%
-2
- C4 -
-
2ZYD
1
6PGD_ECOLI
B:
[17-332]
--------------------------------------------------------
Q
I
G
V
V
G
M
A
V
M
G
R
N
L
A
L
N
I
E
S
R
G
Y
T
V
S
I
F
N
R
S
R
E
K
T
----
E
E
V
I
-----
A
E
N
----
P
G
K
---
K
--
L
--
V
P
Y
Y
T
V
K
E
F
V
E
S
L
E
T
P
R
R
I
L
L
M
V
K
A
G
A
G
T
D
A
A
I
D
S
L
K
P
Y
L
D
K
G
D
I
I
I
D
G
G
N
T
F
F
Q
D
T
I
R
R
N
R
E
L
S
A
E
G
F
N
F
I
G
T
G
V
S
G
G
E
E
G
A
L
K
G
P
S
I
M
P
G
G
Q
K
E
A
Y
E
L
V
A
P
I
L
T
K
I
A
A
V
A
EDG
E
-----
P
------
C
------
V
-------
T
Y
I
G
A
D
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
A
Y
S
L
L
-
K
--
G
G
L
N
-
L
T
N
E
E
L
A
Q
T
F
T
E
W
---
N
N
--
G
E
-
L
S
S
Y
L
I
D
I
------
T
K
D
---
I
F
T
K
K
---
D
--
E
------
D
-
G
-
N
Y
-
L
V
D
V
ILD
E
A
A
---
N
K
G
T
---
G
K
-
W
-
T
S
Q
S
A
L
D
L
G
E
P
L
S
L
I
T
E
S
V
F
A
R
Y
I
S
--
S
L
K
--
D
-
Q
R
V
A
--
A
S
K
V
L
S
G
P
Q
A
Q
P
A
G
D
K
A
E
F
I
E
K
--
24
PsiBlast_CBE
73.20
31%
-6
- C4 -
-
2IYP
1
6PGD_LACLM
B:
[7-323]
---------------------------------------------------------
F
G
V
V
G
M
A
V
M
G
K
N
L
A
L
N
V
E
S
R
G
Y
T
V
----
A
I
Y
N
R
T
----
T
S
K
T
-----
E
E
V
F
K
E
H
Q
D
K
---
N
--
L
--
V
F
T
K
T
L
E
E
F
V
G
S
L
E
K
P
R
R
I
M
L
M
V
Q
A
G
A
A
T
D
A
T
I
K
S
L
L
P
L
L
D
I
G
D
I
L
I
D
G
G
N
T
H
F
P
D
T
M
R
R
N
A
E
L
A
D
S
G
I
N
F
I
G
T
G
V
S
G
G
E
K
G
A
L
L
G
P
S
M
M
P
G
G
Q
K
E
A
Y
D
L
V
A
P
I
F
E
Q
I
A
A
-----
K
-----
A
PQDGKP
C
------
V
-------
A
Y
M
G
A
N
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
S
Y
D
L
L
K
R
IL
G
L
S
N
-
A
E
I
Q
A
I
F
E
E
---
W
---
N
E
--
G
E
-
L
D
S
Y
L
I
E
I
------
T
K
E
---
V
L
K
R
K
---
D
--
D
EGEGYI
V
-
D
-
K
I
-
L
D
K
A
-----
G
---
N
K
G
T
---
G
K
-
W
-
T
S
E
S
A
L
D
L
G
V
P
L
P
L
I
T
E
S
V
F
A
R
Y
I
S
--
T
Y
K
--
D
-
E
--
R
V
K
A
S
K
V
L
S
G
P
A
L
D
F
S
G
D
K
K
E
V
I
E
K
--
27
PsiBlast_CBE
72.93
31%
-0
- C4 -
-
2IZ0
5
6PGD_LACLM
C:
[8-324]
---------------------------------------------------------
F
G
V
V
G
M
A
V
M
G
K
N
L
A
L
N
V
E
S
R
G
Y
T
V
----
A
I
Y
N
R
T
----
T
S
K
T
-----
E
E
V
F
K
E
H
Q
D
K
---
N
--
L
--
V
F
T
K
T
L
E
E
F
V
G
S
L
E
K
P
R
R
I
M
L
M
V
Q
A
G
A
A
T
D
A
T
I
K
S
L
L
P
L
L
D
I
G
D
I
L
I
D
G
G
N
T
H
F
P
D
T
M
R
R
N
A
E
L
A
D
S
G
I
N
F
I
G
T
G
V
S
G
G
E
K
G
A
L
L
G
P
S
M
M
P
G
G
Q
K
E
A
Y
D
L
V
A
P
I
F
E
Q
I
A
A
-----
K
-----
A
------
P
QDGKPC
V
-------
A
Y
M
G
A
N
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
S
Y
D
L
L
K
R
IL
G
L
S
N
-
A
E
I
Q
A
I
F
E
E
---
W
---
N
E
--
G
E
-
L
D
S
Y
L
I
E
I
------
T
K
E
---
V
L
K
R
K
---
D
--
D
EGEGYI
V
-
D
-
K
I
-
L
D
K
A
-----
G
---
N
K
G
T
---
G
K
-
W
-
T
S
E
S
A
L
D
L
G
V
P
L
P
L
I
T
E
S
V
F
A
R
Y
I
S
T
Y
K
D
E
--
R
-
V
--
K
--
A
S
K
V
L
S
G
P
A
L
D
F
S
G
D
K
K
E
V
I
E
K
--
31
PsiBlast_CBE
72.73
33%
-3
- C4 -
-
3FWN
2
6PGD_ECOLI
B:
[17-332]
--------------------------------------------------------
Q
I
G
V
V
G
M
A
V
M
G
R
N
L
A
L
N
I
E
S
R
G
Y
T
V
SIFN
R
S
R
E
K
T
----
E
E
V
I
-----
A
E
N
----
P
G
K
---
K
--
L
--
V
P
Y
Y
T
V
K
E
F
V
E
S
L
E
T
P
R
R
I
L
L
M
V
K
A
G
A
G
T
D
A
A
I
D
S
L
K
P
Y
L
D
K
G
D
I
I
I
D
G
G
N
T
F
F
Q
D
T
I
R
R
N
R
E
L
S
A
E
G
F
N
F
I
G
T
G
V
S
G
G
E
E
G
A
L
K
G
P
S
I
M
P
G
G
Q
K
E
A
Y
E
L
V
A
P
I
L
T
K
I
A
A
VAEDG
E
-----
P
------
C
------
V
-------
T
Y
I
G
A
D
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
A
Y
S
L
L
-
K
--
G
G
L
N
-
L
T
N
E
E
L
A
Q
T
FTE
W
---
N
N
--
G
E
-
L
S
S
Y
L
I
D
I
------
T
K
D
---
I
F
T
K
K
---
D
--
E
------
D
-
G
-
N
Y
-
L
V
D
V
ILDEA
A
---
N
K
G
T
---
G
K
-
W
-
T
S
Q
S
A
L
D
L
G
E
P
L
S
L
I
T
E
S
V
F
A
R
Y
I
S
--
S
L
K
--
D
-
Q
RV
A
--
A
S
K
V
L
S
G
P
Q
A
Q
P
A
G
D
KA
E
F
I
E
K
--
28
PsiBlast_CBE
72.62
31%
-2
- C4 -
-
2IZ0
1
6PGD_LACLM
B:
[8-324]
---------------------------------------------------------
F
G
V
V
G
M
A
V
M
G
K
N
L
A
L
N
V
E
S
R
G
Y
T
V
----
A
I
Y
N
R
T
----
T
S
K
T
-----
E
E
V
F
K
E
H
Q
D
K
---
N
--
L
--
V
F
T
K
T
L
E
E
F
V
G
S
L
E
K
P
R
R
I
M
L
M
V
Q
A
G
A
A
T
D
A
T
I
K
S
L
L
P
L
L
D
I
G
D
I
L
I
D
G
G
N
T
H
F
P
D
T
M
R
R
N
A
E
L
A
D
S
G
I
N
F
I
G
T
G
V
S
G
G
E
K
G
A
L
L
G
P
S
M
M
P
G
G
Q
K
E
A
Y
D
L
V
A
P
I
F
E
Q
I
A
A
-----
K
-----
A
------
P
QDGKPC
V
-------
A
Y
M
G
A
N
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
S
Y
D
L
L
K
R
IL
G
L
S
N
-
A
E
I
Q
A
I
F
E
E
---
W
---
N
E
--
G
E
-
L
D
S
Y
L
I
E
I
------
T
K
E
---
V
L
K
R
K
---
D
--
D
EGEGYI
V
-
D
-
K
I
-
L
D
K
A
-----
G
-----
G
T
---
G
K
-
W
-
T
S
E
S
A
L
D
L
G
V
P
L
P
L
I
T
E
S
V
F
A
R
Y
I
S
T
Y
K
D
E
--
R
-
V
--
K
--
A
S
K
V
L
S
G
P
A
L
D
F
S
G
D
K
K
E
V
I
E
K
--
23
PsiBlast_CBE
72.17
31%
-4
- C4 -
-
2IYP
1
6PGD_LACLM
C:
[7-323]
---------------------------------------------------------
F
G
V
V
G
M
A
V
M
G
K
N
L
A
L
N
V
E
S
R
G
Y
T
V
----
A
I
Y
N
R
T
----
T
S
K
T
-----
E
E
V
F
K
E
H
Q
D
K
---
N
--
L
--
V
F
T
K
T
L
E
E
F
V
G
S
L
E
K
P
R
R
I
M
L
M
V
Q
A
G
A
A
T
D
A
T
I
K
S
L
L
P
L
L
D
I
G
D
I
L
I
D
G
G
N
T
H
F
P
D
T
M
R
R
N
A
E
L
A
D
S
G
I
N
F
I
G
T
G
V
S
G
G
E
K
G
A
L
L
G
P
S
M
M
P
G
G
Q
K
E
A
Y
D
L
V
A
P
I
F
E
Q
I
A
A
-----
K
-----
A
PQDGKP
C
------
V
-------
A
Y
M
G
A
N
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
S
Y
D
L
L
K
R
IL
G
L
S
N
-
A
E
I
Q
A
I
F
E
E
---
W
---
N
E
--
G
E
-
L
D
S
Y
L
I
E
I
------
T
K
E
---
V
L
K
R
K
---
D
--
D
EGEGYI
V
-
D
-
K
I
-
L
D
K
A
-----
G
---
N
K
G
T
---
G
K
-
W
-
T
S
E
S
A
L
D
L
G
V
P
L
P
L
I
T
E
S
V
F
A
R
Y
I
S
--
T
Y
K
--
D
-
E
--
R
V
K
A
S
K
V
L
S
G
P
A
L
D
F
S
G
D
K
K
E
V
I
E
K
--
25
PsiBlast_CBE
71.92
31%
-2
- C4 -
-
2IZ1
3
6PGD_LACLM
C:
[8-324]
---------------------------------------------------------
F
G
V
V
G
M
A
V
M
G
K
N
L
A
L
N
V
E
S
R
G
Y
T
V
----
A
I
Y
N
R
T
----
T
S
K
T
-----
E
E
V
F
K
E
H
Q
D
K
---
N
--
L
--
V
F
T
K
T
L
E
E
F
V
G
S
L
E
K
P
R
R
I
M
L
M
V
Q
A
G
A
A
T
D
A
T
I
K
S
L
L
P
L
L
D
I
G
D
I
L
I
D
G
G
N
T
H
F
P
D
T
M
R
R
N
A
E
L
A
D
S
G
I
N
F
I
G
T
G
V
S
G
G
E
K
G
A
L
L
G
P
S
M
M
P
G
G
Q
K
E
A
Y
D
L
V
A
P
I
F
E
Q
I
A
A
-----
K
-----
A
------
P
QDGKPC
V
-------
A
Y
M
G
A
N
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
S
Y
D
L
L
K
R
IL
G
L
S
N
-
A
E
I
Q
A
I
F
E
E
---
W
---
N
E
--
G
E
-
L
D
S
Y
L
I
E
I
------
T
K
E
---
V
L
K
R
K
---
D
--
D
EGEGYI
V
-
D
-
K
I
-
L
D
K
A
-----
G
---
N
K
G
T
---
G
K
-
W
-
T
S
E
S
A
L
D
L
G
V
P
L
P
L
I
T
E
S
V
F
A
R
Y
I
S
T
Y
K
D
E
--
R
-
V
--
K
--
A
S
K
V
L
S
G
P
A
L
D
F
S
G
D
K
K
E
V
I
E
K
--
26
PsiBlast_CBE
71.73
31%
-1
- C4 -
-
2IZ1
1
6PGD_LACLM
B:
[8-324]
---------------------------------------------------------
F
G
V
V
G
M
A
V
M
G
K
N
L
A
L
N
V
E
S
R
G
Y
T
V
----
A
I
Y
N
R
T
----
T
S
K
T
-----
E
E
V
F
K
E
H
Q
D
K
---
N
--
L
--
V
F
T
K
T
L
E
E
F
V
G
S
L
E
K
P
R
R
I
M
L
M
V
Q
A
G
A
A
T
D
A
T
I
K
S
L
L
P
L
L
D
I
G
D
I
L
I
D
G
G
N
T
H
F
P
D
T
M
R
R
N
A
E
L
A
D
S
G
I
N
F
I
G
T
G
V
S
G
G
E
K
G
A
L
L
G
P
S
M
M
P
G
G
Q
K
E
A
Y
D
L
V
A
P
I
F
E
Q
I
A
A
-----
K
-----
A
------
P
QDGKPC
V
-------
A
Y
M
G
A
N
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
S
Y
D
L
L
K
R
IL
G
L
S
N
-
A
E
I
Q
A
I
F
E
E
---
W
---
N
E
--
G
E
-
L
D
S
Y
L
I
E
I
------
T
K
E
---
V
L
K
R
K
---
D
--
D
EGEGYI
V
-
D
-
K
I
-
L
D
K
A
-----
G
---
N
K
G
T
---
G
K
-
W
-
T
S
E
S
A
L
D
L
G
V
P
L
P
L
I
T
E
S
V
F
A
R
Y
I
S
T
Y
K
D
E
--
R
-
V
--
K
--
A
S
K
V
L
S
G
P
A
L
D
F
S
G
D
K
K
E
V
I
E
K
--
4
PsiBlast_PDB
71.46
31%
1
- C4 -
-
2IYP
2
6PGD_LACLM
A:
[7-323]
---------------------------------------------------------
F
G
V
V
G
M
A
V
M
G
K
N
L
A
L
N
V
E
S
R
G
Y
T
V
----
A
I
Y
N
R
T
----
T
S
K
T
-----
E
E
V
F
K
E
H
Q
D
K
---
N
--
L
--
V
F
T
K
T
L
E
E
F
V
G
S
L
E
K
P
R
R
I
M
L
M
V
Q
A
G
A
A
T
D
A
T
I
K
S
L
L
P
L
L
D
I
G
D
I
L
I
D
G
G
N
T
H
F
P
D
T
M
R
R
N
A
E
L
A
D
S
G
I
N
F
I
G
T
G
V
S
G
G
E
K
G
A
L
L
G
P
S
M
M
P
G
G
Q
K
E
A
Y
D
L
V
A
P
I
F
E
Q
I
A
A
-----
K
-----
A
PQDGKP
C
------
V
-------
A
Y
M
G
A
N
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
S
Y
D
L
L
K
R
IL
G
L
S
N
-
A
E
I
Q
A
I
F
E
E
---
W
---
N
E
--
G
E
-
L
D
S
Y
L
I
E
I
------
T
K
E
---
V
L
K
R
K
---
D
--
D
EGEGYI
V
-
D
-
K
I
-
L
D
K
A
-----
G
---
N
K
G
T
---
G
K
-
W
-
T
S
E
S
A
L
D
L
G
V
P
L
P
L
I
T
E
S
V
F
A
R
Y
I
S
--
T
Y
K
--
D
-
E
--
R
V
K
A
S
K
V
L
S
G
P
A
L
D
F
S
G
D
K
K
E
V
I
E
K
--
43
HHSearch
71.24
33%
15
- C4 -
-
2P4Q
-
6PGD1_YEAST
A:
[9-311]
-----------------------------------------------------
M
S
A
D
F
G
L
I
G
L
A
V
M
G
Q
N
L
I
L
N
A
A
D
H
G
F
T
V
----
C
A
Y
N
R
T
----
Q
S
K
V
-----
D
H
F
----
L
A
N
EAK
G
KS
I
--
I
G
A
T
S
I
E
D
F
I
S
K
L
K
R
P
R
K
V
M
L
L
V
K
A
G
A
P
V
D
A
L
I
N
Q
I
V
P
L
L
E
K
G
D
I
I
I
D
G
G
N
S
H
F
P
D
S
N
R
R
Y
E
E
L
K
K
K
G
I
L
F
V
G
S
G
V
S
G
G
E
E
G
A
R
Y
G
P
S
L
M
P
G
G
S
E
E
A
W
P
H
I
K
N
I
F
Q
S
I
S
A
------------------
K
SDGEPC
C
-------
E
W
V
G
P
A
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
C
E
A
Y
D
I
M
K
R
--
L
--
G
G
F
T
D
K
E
I
S
D
V
---
F
A
K
W
N
N
--
G
-
V
L
D
S
F
L
V
E
I
------
T
R
D
---
I
L
K
F
D
D--
V
DG
K
------
P
---
L
V
-
E
K
I
M
-----
D
T
A
-
G
Q
K
G
---
T
G
-
K
W
T
A
I
N
A
L
D
L
G
M
P
V
T
L
I
G
E
A
V
F
A
R
C
L
S
--
A
L
K
N
E
R
-
I
--
R
--
A
S
K
V
L
P
------------------
45
HHSearch
70.92
35%
-4
- C4 -
-
2W90
1
?
B:
[3-308]
----------------------------------------------------
M
A
K
H
Q
I
G
V
I
G
L
A
V
M
G
K
N
L
A
L
N
I
E
S
K
G
Y
S
V
----
A
V
Y
N
R
L
----
R
E
K
T
-----
D
E
F
----
L
Q
E
A
K-
G
KN
I
--
V
G
T
Y
S
I
E
E
F
V
N
A
L
E
K
P
R
K
I
L
L
M
V
K
A
G
A
P
T
D
A
T
I
E
Q
L
K
P
H
L
E
K
G
D
I
V
I
D
G
G
N
T
Y
F
K
D
T
Q
R
R
N
K
E
L
A
E
L
G
I
H
F
I
G
T
G
V
S
G
G
E
E
G
A
L
K
G
P
S
I
M
P
G
G
Q
K
E
A
H
E
L
V
R
P
I
F
E
A
I
A
A
------------------
K
V
DGEPC
T
-------
T
Y
I
G
P
D
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
A
Y
F
L
L
K
H
V
-
L
--
G
-
M
D
A
A
E
L
H
E
V
---
F
---
A
D
W
N
K
G
E
L
N
S
Y
L
I
E
I
------
T
A
D
---
I
F
T
K
I
D--
E
--
E
------
T
-
G
K
P
L
V
D
V
I
L
-----
D
K
A
G
Q
K
G
T
---
G
K
-
W
-
T
S
Q
N
A
L
D
L
G
V
P
L
P
I
I
T
E
S
V
F
A
R
F
L
S
--
A
M
K
D
E
R
-
V
--
K
--
A
S
K
V
L
A
G
P
----------------
3
PsiBlast_PDB
69.91
31%
8
- C4 -
-
2IYO
1
6PGD_LACLM
A:
[7-322]
----------------------------------------------------------
G
V
V
G
M
A
V
M
G
K
N
L
A
L
N
V
E
S
R
G
Y
T
V
----
A
I
Y
N
R
T
----
T
S
K
T
-----
E
E
V
F
K
E
H
Q
D
K
---
N
--
L
--
V
F
T
K
T
L
E
E
F
V
G
S
L
E
K
P
R
R
I
M
L
M
V
Q
A
G
A
A
T
D
A
T
I
K
S
L
L
P
L
L
D
I
G
D
I
L
I
D
G
G
N
T
H
F
P
D
T
M
R
R
N
A
E
L
A
D
S
G
I
N
F
I
G
T
G
V
S
G
G
E
K
G
A
L
L
G
P
S
M
M
P
G
G
Q
K
E
A
Y
D
L
V
A
P
I
F
E
Q
I
A
A
-----
K
-----
A
------
P
QDGKPC
V
-------
A
Y
M
G
A
N
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
S
Y
D
L
L
K
R
IL
G
L
S
N
-
A
E
I
Q
A
I
F
E
E
---
W
---
N
E
--
G
E
-
L
D
S
Y
L
I
E
I
------
T
K
E
---
V
L
K
R
K
---
D
--
D
EGEGYI
V
-
D
-
K
I
-
L
D
K
A
-----
G
---
N
K
G
T
---
G
K
-
W
-
T
S
E
S
A
L
D
L
G
V
P
L
P
L
I
T
E
S
V
F
A
R
Y
I
S
--
T
Y
K
--
D
-
E
--
R
V
K
A
S
K
V
L
S
G
P
A
L
D
F
S
G
D
K
K
E
V
I
E
K
--
15
PsiBlast_PDB
68.65
34%
17
- C4 -
-
1PGN
2
6PGD_SHEEP
A:
[1-294]
-----------------------------------------------------
A
Q
A
D
I
A
L
I
G
L
A
V
M
G
Q
N
L
I
L
N
M
N
D
H
G
F
V
V
----
C
A
F
N
R
T
----
V
S
K
V
D
D
F
L
A
N
E
A
----
K
G
T
---
K
--
V
--
L
G
A
H
S
L
E
E
M
V
S
K
L
K
K
P
R
R
I
I
L
L
V
K
A
G
Q
A
V
D
N
F
I
E
K
L
V
P
L
L
D
I
G
D
I
I
I
D
G
G
N
S
E
Y
R
D
T
M
R
R
C
R
D
L
K
D
K
G
I
L
F
V
G
S
G
V
S
G
G
E
D
G
A
R
Y
G
P
S
L
M
P
G
G
N
K
E
A
W
P
H
I
K
A
I
F
Q
G
I
A
A
-----
K
-----
V
------
G
TGEPC-
C
-------
D
W
V
G
D
D
G
A
G
H
F
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
C
E
A
Y
H
L
M
-
K
--
D
V
L
G
-
L
G
H
K
E
M
A
K
A
F
E
E
W
---
N
K
---
T
E
L
D
S
F
L
I
E
I
T
A
S
I
L
K
F
Q
D
---
A
D
G
K
H
---
L
---------
L
-
P
-
K
I
-
R
D
S
A
-----
G
---
Q
K
G
T
---
G
K
-
W
-
T
A
I
S
A
L
E
Y
G
V
P
V
T
L
I
G
E
A
V
F
A
R
C
L
S
--
S
L
K
--
D
-------------------------------
17
PsiBlast_PDB
68.30
34%
19
- C4 -
-
1PGP
1
6PGD_SHEEP
A:
[1-294]
-----------------------------------------------------
A
Q
A
D
I
A
L
I
G
L
A
V
M
G
Q
N
L
I
L
N
M
N
D
H
G
F
V
V
----
C
A
F
N
R
T
----
V
S
K
V
D
D
F
L
A
N
E
A
----
K
G
T
---
K
--
V
--
L
G
A
H
S
L
E
E
M
V
S
K
L
K
K
P
R
R
I
I
L
L
V
K
A
G
Q
A
V
D
N
F
I
E
K
L
V
P
L
L
D
I
G
D
I
I
I
D
G
G
N
S
E
Y
R
D
T
M
R
R
C
R
D
L
K
D
K
G
I
L
F
V
G
S
G
V
S
G
G
E
D
G
A
R
Y
G
P
S
L
M
P
G
G
N
K
E
A
W
P
H
I
K
A
I
F
Q
G
I
A
A
-----
K
-----
V
------
G
TGEPC-
C
-------
D
W
V
G
D
D
G
A
G
H
F
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
C
E
A
Y
H
L
M
-
K
--
D
V
L
G
-
L
G
H
K
E
M
A
K
A
F
E
E
W
---
N
K
---
T
E
L
D
S
F
L
I
E
I
T
A
S
I
L
K
F
Q
D
---
A
D
G
K
H
---
L
---------
L
-
P
-
K
I
-
R
D
S
A
-----
G
---
Q
K
G
T
---
G
K
-
W
-
T
A
I
S
A
L
E
Y
G
V
P
V
T
L
I
G
E
A
V
F
A
R
C
L
S
--
S
L
K
--
D
-------------------------------
12
PsiBlast_PDB
68.21
33%
14
- C4 -
-
4GWK
4
6PGD_HUMAN
A:
[3-298]
-----------------------------------------------------
A
Q
A
D
I
A
L
I
G
L
A
V
M
G
Q
N
L
I
L
N
M
N
D
H
G
F
V
V
----
C
A
F
N
R
T
----
V
S
K
V
D
D
F
L
A
N
E
A
----
K
G
T
---
K
--
V
--
V
G
A
Q
S
L
K
E
M
V
S
K
L
K
K
P
R
R
I
I
L
L
V
K
A
G
Q
A
V
D
D
F
I
E
K
L
V
P
L
L
D
T
G
D
I
I
I
D
G
G
N
S
E
Y
R
D
T
T
R
R
C
R
D
L
K
A
K
G
I
L
F
V
G
S
G
V
S
G
G
E
E
G
A
R
Y
G
P
S
L
M
P
G
G
N
K
E
A
W
P
H
I
K
T
I
F
Q
G
I
A
A
-----
K
-----
V
------
G
TGEPC-
C
-------
D
W
V
G
D
E
G
A
G
H
F
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
C
E
A
Y
H
L
M
K
D
VL
G
M
A
Q
-
D
E
M
A
Q
A
F
E
D
---
W
---
N
K
---
T
E
L
D
S
F
L
I
E
I
------
T
A
N
---
I
L
K
F
Q
---
D
--
T
DGKHL-
L
-
P
-
K
I
-
R
D
S
A
-----
G
---
Q
K
G
T
---
G
K
-
W
-
T
A
I
S
A
L
E
Y
G
V
P
V
T
L
I
G
E
A
V
F
A
R
C
L
S
--
S
L
K
--
D
-------------------------------
11
PsiBlast_PDB
68.07
33%
14
- C4 -
-
4GWG
2
6PGD_HUMAN
A:
[3-298]
-----------------------------------------------------
A
Q
A
D
I
A
L
I
G
L
A
V
M
G
Q
N
L
I
L
N
M
N
D
H
G
F
V
V
----
C
A
F
N
R
T
----
V
S
K
V
D
D
F
L
A
N
E
A
----
K
G
T
---
K
--
V
--
V
G
A
Q
S
L
K
E
M
V
S
K
L
K
K
P
R
R
I
I
L
L
V
K
A
G
Q
A
V
D
D
F
I
E
K
L
V
P
L
L
D
T
G
D
I
I
I
D
G
G
N
S
E
Y
R
D
T
T
R
R
C
R
D
L
K
A
K
G
I
L
F
V
G
S
G
V
S
G
G
E
E
G
A
R
Y
G
P
S
L
M
P
G
G
N
K
E
A
W
P
H
I
K
T
I
F
Q
G
I
A
A
-----
K
-----
V
------
G
TGEPC-
C
-------
D
W
V
G
D
E
G
A
G
H
F
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
C
E
A
Y
H
L
M
K
D
VL
G
M
A
Q
-
D
E
M
A
Q
A
F
E
D
---
W
---
N
K
---
T
E
L
D
S
F
L
I
E
I
------
T
A
N
---
I
L
K
F
Q
---
D
--
T
DGKHL-
L
-
P
-
K
I
-
R
D
S
A
-----
G
---
Q
K
G
T
---
G
K
-
W
-
T
A
I
S
A
L
E
Y
G
V
P
V
T
L
I
G
E
A
V
F
A
R
C
L
S
--
S
L
K
--
D
-------------------------------
22
PsiBlast_CBE
63.84
36%
27
- C4 -
-
2W8Z
2
?
B:
[6-295]
--------------------------------------------------------
Q
I
G
V
I
G
L
A
V
M
G
K
N
L
A
L
N
I
E
S
K
G
Y
S
V
AVYN
R
L
R
E
K
T
----
D
E
F
L
-----
Q
E
A
----
K
G
K
---
N
--
I
--
V
G
T
Y
S
I
E
E
F
V
N
A
L
E
K
P
R
K
I
L
L
M
V
K
A
G
A
P
T
D
A
T
I
E
Q
L
K
P
H
L
E
K
G
D
I
V
I
D
G
G
N
T
Y
F
K
D
T
Q
R
R
N
K
E
L
A
E
L
G
I
H
F
I
G
T
G
V
S
G
G
E
E
G
A
L
K
G
P
S
I
M
P
G
G
Q
K
E
A
H
E
L
V
R
P
I
F
E
A
I
A
A
KVDG-
E
-----
P
------
C
------
T
-------
T
Y
I
G
P
D
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
A
Y
F
L
L
K
H
VL
G
M
D
A
-
A
E
L
H
E
V
F
A
D
---
W
---
N
K
--
G
E
-
L
N
S
Y
L
I
E
I
------
T
A
D
IFT
K
I
D
E
E
---
T
--
G
------
K
-
P
-
L
V
-
D
V
I
L
-----
D
---
K
A
G
Q
KGT
G
K
-
W
-
T
S
Q
N
A
L
D
L
G
V
P
L
P
I
I
T
E
S
V
F
A
R
F
L
S
--
A
M
K
--
D
-------------------------------
2
PsiBlast_PDB
63.84
36%
28
- C4 -
-
2W8Z
1
?
A:
[6-295]
--------------------------------------------------------
Q
I
G
V
I
G
L
A
V
M
G
K
N
L
A
L
N
I
E
S
K
G
Y
S
V
A
V
Y
N
R
L
R
E
K
T
----
D
E
F
L
-----
Q
E
A
----
K
G
K
---
N
--
I
--
V
G
T
Y
S
I
E
E
F
V
N
A
L
E
K
P
R
K
I
L
L
M
V
K
A
G
A
P
T
D
A
T
I
E
Q
L
K
P
H
L
E
K
G
D
I
V
I
D
G
G
N
T
Y
F
K
D
T
Q
R
R
N
K
E
L
A
E
L
G
I
H
F
I
G
T
G
V
S
G
G
E
E
G
A
L
K
G
P
S
I
M
P
G
G
Q
K
E
A
H
E
L
V
R
P
I
F
E
A
I
A
A
KVDG-
E
-----
P
------
C
------
T
-------
T
Y
I
G
P
D
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
A
Y
F
L
L
K
H
V
L
G
M
D
A
-
A
E
L
H
E
V
F
A
D
---
W
---
N
K
--
G
E
-
L
N
S
Y
L
I
E
I
------
T
A
D
I
F
T
K
I
D
E
E
---
T
--
G
------
K
-
P
-
L
V
-
D
V
I
L
-----
D
---
K
A
G
Q
K
GT
G
K
-
W
-
T
S
Q
N
A
L
D
L
G
V
P
L
P
I
I
T
E
S
V
F
A
R
F
L
S
--
A
M
K
--
D
-------------------------------
1
PsiBlast_PDB
63.62
36%
30
- C4 -
-
2W90
2
?
A:
[7-296]
--------------------------------------------------------
Q
I
G
V
I
G
L
A
V
M
G
K
N
L
A
L
N
I
E
S
K
G
Y
S
V
A
V
Y
N
R
L
R
E
K
T
----
D
E
F
L
-----
Q
E
A
----
K
G
K
---
N
--
I
--
V
G
T
Y
S
I
E
E
F
V
N
A
L
E
K
P
R
K
I
L
L
M
V
K
A
G
A
P
T
D
A
T
I
E
Q
L
K
P
H
L
E
K
G
D
I
V
I
D
G
G
N
T
Y
F
K
D
T
Q
R
R
N
K
E
L
A
E
L
G
I
H
F
I
G
T
G
V
S
G
G
E
E
G
A
L
K
G
P
S
I
M
P
G
G
Q
K
E
A
H
E
L
V
R
P
I
F
E
A
I
A
A
K
V
DG-
E
-----
P
------
C
------
T
-------
T
Y
I
G
P
D
G
A
G
H
Y
V
K
M
V
H
N
G
I
E
Y
G
D
M
Q
L
I
A
E
A
Y
F
L
L
K
H
V
L
G
M
D
A
-
A
E
L
H
E
V
F
A
D
---
W
---
N
K
--
G
E
-
L
N
S
Y
L
I
E
I
------
T
A
D
I
F
T
K
I
D
E
E
---
T
--
G
------
K
-
P
-
L
V
-
D
V
I
L
-----
D
---
K
A
G
Q
K
GT
G
K
-
W
-
T
S
Q
N
A
L
D
L
G
V
P
L
P
I
I
T
E
S
V
F
A
R
F
L
S
--
A
M
K
--
D
-------------------------------