@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_ECR_BOMMO: (2016-03-18 )
MRVENVDNVSFALNGRADEWCMSVETRLDSLVREKSEVKAYVGGCPSVITDAGAYDALFDMRRRWSNNGGFPLRMLEESSSEVTSSSALGLPPAMVMSPESLASPEYRALELWSYDDGITYNTAQSLLGACNMQQQQLQPQQPHPAPPTLPTMPLPMPPTTPKSENESMSSGREELSPASSINGCSADADARRQKKGPAPRQQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKNAVYICKFGHACEMDMYMRRKCQECRLKKCLAVGMRPECVIQEPSKNKDRQRQKKDKGILLPVSTTTVEDHMPPIMQCDPPPPEAARIHEVVPRYLSEKLMEQNRQKNIPPLSANQKSLIARLVWYQEGYEQPSDEDLKRVTQTWQSDEEDEESDLPFRQITEMTILTVQLIVEFAKGLPGFSKISQSDQITLLKASSSEVMMLRVARRYDAASDSVLFANNKAYTRDNYRQGGMAYVIEDLLHFCRCMFAMGMDNVHFALLTAIVIFSDRPGLEQPSLVEEIQRYYLNTLRIYIINQNSASSRCAVIYGRILSVLTELRTLGTQNSNMCISLKLKNRKLPPFLEEIWDVAEVATTHPTVLPPTNPVVL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200-.-......210.......220.......230.......240.........250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360...-....370.......380..------.......390..---.....400.......410.......420.......430.......440.......450.......460.......470-..-.....480.......490.......500....-...510.......520.......530-.......540.......550.......560.......570.--......580.......590.......600....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRVENVDN
V
S
F
A
LNGRA
D
E
W
C
M
S
V
E
T
R
L
D
S
L
V
R
E
K
S
E
V
K
A
Y
VGG
C
P
S
V
ITDAG
A
Y
D
A
L
F
D
M
R
R
R
WSNNGGF
P
L
R
MLEESSSEVTSSSALGLPPA
M
V
M
S
P
E
SLASPE
Y
R
A
L
E
L
WSYDDGI
T
Y
N
T
A
Q
S
L
L
G
ACN
M
Q
Q
Q
QLQPQQPHPAPPTLPTMPLPMPPTTPKSENESMSS
G
R
E
ELSPASSINGCSA
D
A
D
A
R
RQKKGPAPRQ-Q-E
E
L
C
L
V
CGDRASG
Y
H
YN
A
L
T
C
E
G
C
K
G
F
F
R
RSVTKN
A
V
--
Y
I
C
KFGHAC
E
M
D
M
Y
M
R
R
K
C
Q
E
C
R
L
K
K
C
L
A
VGMRP
E
C
V
IQEPSKN
K
D
R
Q
R
Q
KKDK
G
I
L
L
PVSTTTVEDHMPPIMQCDPPPP
E
A
A
R
I
H
E
V
V
P
R
Y
L
S
E
K
L
M
E
Q
N
RQKNIPPLSA
N
Q
K
S
L
I
A
R
L
V
W
Y
Q
E-GYEQP
S
D
E
D
L
K
R
V
T
Q
--
T
W------QSDEEDEESDL
P
---
F
R
Q
I
T
E
M
T
I
L
T
V
Q
L
I
V
E
F
A
KGLP
G
F
S
KISQSD
Q
I
T
L
L
KASSSE
V
M
M
L
R
V
A
R
R
YDAASD
S
V
L
FANNKAYTRDNYRQG
G
M
-
A
Y
-
V
I
E
D
L
L
H
F
C
R
C
M
F
A
MGMD
N
V
H
F
A
L
L
T
A
I
V
IFS-DRPGLEQ
P
S
L
V
E
E
I
Q
R
Y
Y
L
N
T
L
R
I
Y
I
-
I
NQNSAS
S
R
C
A
V
I
Y
G
R
I
L
S
V
L
T
E
L
R
T
LGTQNS
N
M
C
I
S
L
K
LK--NRKL
P
P
F
L
E
E
I
W
D
V
A
E
V
ATTHPTVLPPTNPVVL
2
PsiBlast_PDB
88.84
89%
-132
- C3 -
2R40
1
D:
[21-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
P
L
T
A
N
Q
K
S
L
I
A
R
L
V
W
Y
Q
E
-
G
Y
E
Q
P
S
E
E
D
L
K
R
V
T
Q
--
T
----------------
D
M
P
---
F
R
Q
I
T
E
M
T
I
L
T
V
Q
L
I
V
E
F
A
K
G
L
P
G
F
A
K
I
S
Q
S
D
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
V
A
R
R
Y
D
A
A
T
D
S
V
L
F
A
N
N
Q
A
Y
T
R
D
N
Y
R
K
A
G
M
-
A
Y
-
V
I
E
D
L
L
H
F
C
R
C
M
Y
S
M
M
M
D
N
V
H
Y
A
L
L
T
A
I
V
I
F
S
-
D
R
P
G
L
E
Q
P
L
L
V
E
E
I
Q
R
Y
Y
L
N
T
L
R
V
Y
I
-
L
N
Q
N
S
A
S
P
R
C
A
V
I
F
G
K
I
L
G
I
L
T
E
I
R
T
L
G
M
Q
N
S
N
M
C
I
S
L
K
L
K
--
N
R
K
L
P
P
F
L
E
E
I
W
D
V
A
------------------
3
PsiBlast_PDB
88.09
89%
-124
- C3 -
4UMM
1
?
G:
[21-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
P
L
T
A
N
Q
K
S
L
I
A
R
L
V
W
Y
Q
E
-
G
Y
E
Q
P
S
E
E
D
L
K
R
V
T
Q
--
T
W
-------------
D
S
D
M
P
---
F
R
Q
I
T
E
M
T
I
L
T
V
Q
L
I
V
E
F
A
K
G
L
P
G
F
A
K
I
S
Q
S
D
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
V
A
R
R
Y
D
A
A
T
D
S
V
L
F
A
N
N
Q
A
Y
T
R
D
N
Y
R
K
A
G
M
-
A
Y
-
V
I
E
D
L
L
H
F
C
R
C
M
Y
S
M
M
M
D
N
V
H
Y
A
L
L
T
A
I
V
I
F
S
-
D
R
P
G
L
E
Q
P
L
L
V
E
E
I
Q
R
Y
Y
L
N
T
L
R
V
Y
I
-
L
N
Q
N
S
A
S
P
R
C
A
V
I
F
G
K
I
L
G
I
L
T
E
I
R
T
L
G
M
Q
N
S
N
M
C
I
S
L
K
L
K
--
N
R
K
L
P
P
F
L
E
E
I
W
D
V
A
------------------
1
PsiBlast_PDB
87.72
89%
-124
- C3 -
1R1K
1
D:
[21-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
P
L
T
A
N
Q
K
S
L
I
A
R
L
V
W
Y
Q
E
-
G
Y
E
Q
P
S
E
E
D
L
K
R
V
T
Q
--
T
W
-------------
D
S
D
M
P
---
F
R
Q
I
T
E
M
T
I
L
T
V
Q
L
I
V
E
F
A
K
G
L
P
G
F
A
K
I
S
Q
S
D
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
V
A
R
R
Y
D
A
A
T
D
S
V
L
F
A
N
N
Q
A
Y
T
R
D
N
Y
R
K
A
G
M
-
A
Y
-
V
I
E
D
L
L
H
F
C
R
C
M
Y
S
M
M
M
D
N
V
H
Y
A
L
L
T
A
I
V
I
F
S
-
D
R
P
G
L
E
Q
P
L
L
V
E
E
I
Q
R
Y
Y
L
N
T
L
R
V
Y
I
-
L
N
Q
N
S
A
S
P
R
C
A
V
I
F
G
K
I
L
G
I
L
T
E
I
R
T
L
G
M
Q
N
S
N
M
C
I
S
L
K
L
K
--
N
R
K
L
P
P
F
L
E
E
I
W
D
V
A
------------------
45
Fugue
86.55
39%
-95
- C3 -
4NQA
1
NR1H2_HUMAN
I:
[5-389]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
P
A
P
K
M
-
L
G
H
E
L
C
R
V
C
G
D
K
A
S
G
F
H
Y
N
V
L
S
C
E
G
C
K
G
F
F
R
R
S
V
V
R
G
G
A
RR
Y
A
C
R
G
G
G
T
C
Q
M
D
A
F
M
R
R
K
C
Q
Q
C
R
L
R
K
C
K
E
A
G
M
R
E
Q
C
V
L
S
E
E
Q
I
R
K
K
K
I
R
K
Q
Q
Q
Q
----
E
S
Q
S
Q
S
Q
S
P
V
G
P
Q
G
S
S
S
S
A
S
G
P
G
A
-------
S
P
G
G
S
E
A
G
S
Q
G
S
G
E
G
E
G
V
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
-
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
WP
L
G
------
A
D
P
Q
S
R
D
A
R
Q
Q
R
---
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
-
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
-
R
I
K
R
P
Q
D
Q
---
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
V
-------------------
5
PsiBlast_PDB
85.60
89%
-130
- C3 -
3IXP
1
?
D:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
P
L
T
A
N
Q
K
S
L
I
A
R
L
V
Y
Y
Q
E
-
G
Y
E
Q
-------------------------------
M
P
---
F
R
Q
I
T
E
M
T
I
L
T
V
Q
L
I
V
E
F
A
K
G
L
P
G
F
S
K
I
S
Q
S
D
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
V
A
R
R
Y
D
A
A
T
D
S
V
L
F
A
N
N
Q
A
Y
T
R
D
N
Y
R
K
A
G
M
-
A
Y
-
V
I
E
D
L
L
H
F
C
R
C
M
Y
S
M
M
M
D
N
V
H
Y
A
L
L
T
A
I
V
I
F
S
-
D
R
P
G
L
E
Q
P
S
L
V
E
E
I
Q
R
Y
Y
L
N
T
L
R
V
Y
I
-
L
N
Q
N
S
A
S
P
R
S
A
V
I
F
G
K
I
L
G
I
L
T
E
I
R
T
L
G
M
Q
N
S
N
M
C
I
S
L
K
L
K
--
N
R
K
L
P
P
F
L
E
E
I
W
D
V
A
------------------
9
PsiBlast_PDB
85.37
37%
-102
- C3 -
4NQA
1
NR1H2_HUMAN (first)
B:
[4-388]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
G
P
A
P
K
M
L
G
-
H
E
L
C
R
V
C
G
D
K
A
S
G
F
H
Y
N
V
L
S
C
E
G
C
K
G
F
F
R
R
S
V
V
R
G
G
A
RR
Y
A
C
R
G
G
G
T
C
Q
M
D
A
F
M
R
R
K
C
Q
Q
C
R
L
R
K
C
K
E
A
G
M
R
E
Q
C
V
L
S
E
E
Q
I
R
K
K
K
I
R
K
Q
Q
--------
Q
Q
E
S
Q
S
Q
S
Q
S
P
V
---
G
P
Q
G
S
S
S
----------------
Q
G
S
G
E
G
E
G
V
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
-
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
---
P
W
------
P
L
G
A
D
P
Q
S
R
D
A
R
QQR
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
-
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
----
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
--------------------
4
PsiBlast_PDB
84.63
89%
-126
- C3 -
1R20
1
D:
[20-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
P
L
T
A
N
Q
K
S
L
I
A
R
L
V
Y
Y
Q
E
-
G
Y
E
Q
P
S
E
E
D
L
K
R
----------------------
D
M
P
---
F
R
Q
I
T
E
M
T
I
L
T
V
Q
L
I
V
E
F
A
K
G
L
P
G
F
S
K
I
S
Q
S
D
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
V
A
R
R
Y
D
A
A
T
D
S
V
L
F
A
N
N
Q
A
Y
T
R
D
N
Y
R
K
A
G
M
-
A
Y
-
V
I
E
D
L
L
H
F
C
R
C
M
Y
S
M
M
M
D
N
V
H
Y
A
L
L
T
A
I
V
I
F
S
-
D
R
P
G
L
E
Q
P
S
L
V
E
E
I
Q
R
Y
Y
L
N
T
L
R
V
Y
I
-
L
N
Q
N
S
A
S
P
R
S
A
V
I
F
G
K
I
L
G
I
L
T
E
I
R
T
L
G
M
Q
N
S
N
M
C
I
S
L
K
L
K
--
N
R
K
L
P
P
F
L
E
E
I
W
D
V
-------------------
6
PsiBlast_PDB
79.40
61%
-111
- C3 -
4OZT
1
?
E:
[1-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
P
I
S
P
E
Q
E
E
L
I
H
R
L
V
Y
F
Q
N
-
E
Y
E
Q
P
S
D
E
D
L
K
R
I
S
N
--
T
--------
P
S
E
G
E
D
Q
S
D
L
N
---
F
R
H
I
T
E
I
T
I
L
T
V
Q
L
I
V
E
F
A
K
R
L
P
G
F
D
K
L
L
R
E
D
Q
I
A
L
L
K
A
C
S
S
E
V
M
M
L
R
M
A
R
R
Y
D
V
G
S
D
S
I
L
F
A
N
N
Q
P
Y
T
R
D
S
Y
S
L
A
G
M
-
G
E
-
T
V
D
D
L
L
R
F
C
R
Q
M
Y
G
M
K
V
D
N
A
E
Y
A
L
L
T
A
I
V
I
F
S
-
E
R
P
S
L
I
E
G
W
K
V
E
K
I
Q
E
I
Y
L
E
A
L
K
V
Y
V
-
D
N
R
R
K
P
A
S
--
G
T
I
F
A
K
L
L
S
V
L
T
E
L
R
T
L
G
N
L
N
S
E
M
C
F
S
L
K
L
K
--
N
K
K
L
P
P
F
L
A
E
I
W
D
V
-------------------
7
PsiBlast_PDB
77.95
58%
-114
- C3 -
2NXX
1
?
E:
[10-244]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
P
---
E
Q
E
E
L
I
H
R
L
V
Y
F
Q
N
-
E
Y
E
H
P
S
E
E
D
V
K
R
I
I
N
-------------
D
G
E
D
Q
C
D
V
R
---
F
R
H
I
T
E
I
T
I
L
T
V
Q
L
I
V
E
F
A
K
R
L
P
G
F
D
K
L
L
R
E
D
Q
I
A
L
L
K
A
C
S
S
E
V
M
M
F
R
M
A
R
R
Y
D
V
Q
T
D
S
I
L
F
V
N
N
Q
P
Y
S
R
D
S
Y
N
L
A
G
M
-
G
E
-
T
I
E
D
L
L
H
F
C
R
T
M
Y
S
M
R
V
D
N
A
E
Y
A
L
L
T
A
I
V
I
F
S
-
E
R
P
A
L
I
E
G
W
K
V
E
K
I
Q
E
I
Y
L
E
A
L
R
A
Y
V
---
D
N
R
R
K
P
K
P
G
T
I
F
A
K
L
L
S
V
L
T
E
L
R
T
L
G
N
Q
N
S
E
M
C
F
S
L
K
L
K
--
N
K
K
L
P
P
F
L
A
E
I
W
D
V
-------------------
23
HHSearch
77.62
58%
-108
- C3 -
1Z5X
1
?
E:
[73-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
T
P
E
Q
E
E
L
I
H
R
L
V
Y
F
Q
N
-
E
Y
E
H
P
S
P
E
D
I
K
R
I
V
N
--
A
-------
A
-
P
E
E
E
N
V
A
E
E
R
---
F
R
H
I
T
E
I
T
I
L
T
V
Q
L
I
V
E
F
S
K
R
L
P
G
F
D
K
L
I
R
E
D
Q
I
A
L
L
K
A
C
S
S
E
V
M
M
F
R
M
A
R
R
Y
D
A
E
T
D
S
I
L
F
A
T
N
Q
P
Y
T
R
E
S
Y
T
V
A
G
M
-
G
D
-
T
V
E
D
L
L
R
F
C
R
H
M
C
A
M
K
V
D
N
A
E
Y
A
L
L
T
A
I
V
I
F
S
-
E
R
P
S
L
S
E
G
W
K
V
E
K
I
Q
E
I
Y
I
E
A
L
K
A
Y
V
-
E
N
R
R
K
--
P
Y
A
T
T
I
F
A
K
L
L
S
V
L
T
E
L
R
T
L
G
N
M
N
S
E
T
C
F
S
L
K
L
K
--
N
R
K
V
P
S
F
L
E
E
I
W
D
V
V
------------------
8
PsiBlast_PDB
75.01
50%
-106
- C3 -
1Z5X
1
?
E:
[73-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
T
P
E
Q
E
E
L
I
H
R
L
V
Y
F
Q
N
-
E
Y
E
H
P
S
P
E
D
I
K
R
I
V
N
--
A
--------
A
P
E
E
E
N
V
A
E
E
R
---
F
R
H
I
T
E
I
T
I
L
T
V
Q
L
I
V
E
F
S
K
R
L
P
G
F
D
K
L
I
R
E
D
Q
I
A
L
L
K
A
C
S
S
E
V
M
M
F
R
M
A
R
R
Y
D
A
E
T
D
S
I
L
F
A
T
N
Q
P
Y
T
R
E
S
Y
T
V
A
G
M
-
G
D
-
T
V
E
D
L
L
R
F
C
R
H
M
C
A
M
K
V
D
N
A
E
Y
A
L
L
T
A
I
V
I
F
S
-
E
R
P
S
L
S
E
G
W
K
V
E
K
I
Q
E
I
Y
I
E
A
L
K
A
Y
V
---
E
N
R
R
K
P
Y
A
T
T
I
F
A
K
L
L
S
V
L
T
E
L
R
T
L
G
N
M
N
S
E
T
C
F
S
L
K
L
K
--
N
R
K
V
P
S
F
L
E
E
I
W
D
V
V
------------------
14
PsiBlast_PDB
72.35
38%
-110
- C3 -
3FC6
1
NR1H3_MOUSE
B:
[24-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
-
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
---
P
W
PIAPDP
Q
S
R
E
A
R
Q
Q
R
------
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
-
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
----
P
H
D
P
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
V
-------------------
15
PsiBlast_PDB
71.08
38%
-111
- C3 -
3FAL
1
NR1H3_MOUSE
B:
[23-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
-
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
---
P
W
PP----
Q
S
R
E
A
R
Q
Q
R
------
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
-
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
----
P
H
D
P
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
V
-------------------
18
PsiBlast_PDB
71.06
37%
-110
- C3 -
3IPU
1
NR1H3_HUMAN
A:
[40-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
-
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
---
P
W
PP----
H
S
R
E
A
R
Q
Q
R
------
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
-
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
-
S
I
H
H
P
H
D
R
---
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
V
-------------------
17
PsiBlast_PDB
70.75
37%
-117
- C3 -
3IPS
1
NR1H3_HUMAN
A:
[41-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
-------------
V
T
---
P
W
P------
S
R
E
A
R
Q
Q
R
------
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
-
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
-
S
I
H
H
P
H
D
R
---
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
------------------
19
PsiBlast_PDB
70.38
37%
-119
- C3 -
5AVI
1
?
A:
[40-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
------------
R
V
T
---
P
W
PP----
H
S
R
E
A
R
Q
Q
R
------
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
-
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
-
S
I
H
H
P
H
D
R
---
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
------------------
16
PsiBlast_PDB
68.90
37%
-113
- C3 -
3IPQ
1
NR1H3_HUMAN
A:
[41-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
--------------
T
---
P
W
P--------
E
A
R
Q
Q
R
------
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
-
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
-
S
I
H
H
P
H
D
R
---
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
V
-------------------
20
PsiBlast_PDB
68.50
37%
-116
- C3 -
5AVL
1
?
A:
[40-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
-------------
V
T
---
P
W
--------
R
E
A
R
Q
Q
R
------
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
-
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
-
S
I
H
H
P
H
D
R
---
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
-----------------
47
Fugue
66.43
25%
-87
- C3 -
1BSX
1
THB_HUMAN
A:
[10-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
--
P
E
------
D
I
G
Q
A
P
K
V
D
L
E
A
---
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
-
G
V
-
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
-
N
Y
R
K
H
H
V
T
H
---
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
CP
T
E
L
F
P
P
L
F
L
E
V
F
E
D
-------------------
10
PsiBlast_PDB
66.37
53%
-130
- C3 -
4OZR
-
?
E:
[2-197]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
P
E
Q
E
E
L
I
H
R
L
V
Y
F
Q
N
-
E
Y
E
Q
P
S
D
E
D
-------------------------------
F
R
H
I
T
E
I
T
I
L
T
V
Q
L
I
V
E
F
A
K
R
L
P
G
F
D
K
L
L
R
E
D
Q
I
A
L
L
K
A
C
S
S
E
V
M
M
L
R
M
A
R
R
Y
D
V
G
S
D
S
I
L
-------------------
A
-
T
V
D
D
L
L
R
F
C
R
Q
M
Y
G
M
K
V
D
N
A
E
Y
A
L
L
T
A
I
V
I
F
S
-
E
R
P
S
L
I
E
G
W
K
V
E
K
I
Q
E
I
Y
L
E
A
L
K
V
Y
V
---
D
N
R
R
K
P
R
S
G
T
I
F
A
K
L
L
S
V
L
T
E
L
R
T
L
G
N
L
N
S
E
M
C
F
S
L
K
L
K
--
N
K
K
L
P
P
F
L
A
E
-----------------------