@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_PPARG_RAT: (2016-03-19 )
MGETLGDPPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMDDHSHSFDIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQLLHVIKKTETDMSLHPLLQEIYKDLY
Atome Classification :
(166 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGETLGDPPVDPEHGAFADALPMSTS
Q
E
I
T
M
VDTEMPFWPTNFGISS
V
D
L
S
V
MDDHSHSFDI
K
P
F
T
T
VDFSSISAPHYEDIPFTRADP
M
V
AD
Y
K
YDL
K
L
Q
E
Y
Q
S
A
IKVEPASPPYY
S
E
K
T
Q
L
YNRPHEEPSN
S
L
M
A
I
E
C
R
VCGDKASGF
H
Y
G
V
H
A
C
E
G
C
K
G
F
F
R
R
T
I
R
L
K
L
I
Y
DRCD
L
N
C
R
I
HKKSRN
K
C
Q
Y
C
R
F
Q
K
C
L
A
VGMSHNAIRFGRMP
Q
A
E
K
E
K
L
L
A
E
I
S
S
D
I
D
QLNPE
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
SFPLT
K
A
K
A
R
A
I
L
TGKTTDKS
P
F
V
I
Y
D
M
N
S
LMMGED
K
I
K
F
KHIT
P
L
Q
E
Q
S
K
E
V
A
I
R
I
FQGCQFR
S
V
E
A
V
Q
E
I
T
E
Y
A
KNIP
G
F
I
N
LDLND
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
MNKD
G
V
L
ISEGQ
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
FMEP
K
F
E
F
A
V
K
F
N
A
L
ELDDS
D
L
A
I
F
I
A
V
I
I
LSGDRPGLLNVK
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
LNHP
E
S
S
Q
L
F
A
K
V
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
H
V
I
K
KTETDM
S
L
H
P
L
L
Q
E
I
Y
K
DLY
2
PsiBlast_PDB
94.42
98%
-130
- C3 -
3E00
1
PPARG_HUMAN
D:
[49-419]
--------------------------------------------------------------------------------------------------------------------------------------
M
A
I
E
C
R
V
C
G
D
K
A
S
G
F
H
Y
G
V
H
A
C
E
G
C
K
G
F
F
R
R
T
I
R
L
K
L
I
Y
D
R
C
D
L
N
C
R
I
H
K
K
S
R
N
K
C
Q
Y
C
R
F
Q
K
C
L
A
V
G
M
S
H
N
A
I
R
F
G
R
M
P
Q
A
E
K
E
K
L
L
A
E
I
S
S
D
I
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
--------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
1
PsiBlast_PDB
91.76
98%
-128
- C3 -
3DZU
1
PPARG_HUMAN
D:
[50-419]
---------------------------------------------------------------------------------------------------------------------------------------
A
I
E
C
R
V
C
G
D
K
A
S
G
F
H
Y
G
V
H
A
C
E
G
C
K
G
F
F
R
R
T
I
R
L
K
L
I
Y
D
R
C
D
L
N
C
R
I
H
K
K
S
R
N
K
C
Q
Y
C
R
F
Q
K
C
L
A
V
G
M
S
H
N
A
I
R
F
G
R
M
P
Q
A
E
K
E
K
L
L
A
E
I
S
S
D
I
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
165
PsiBlast_CBE
84.18
98%
-135
- C3 -
3ET3
1
PPARG_HUMAN
A:
[22-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
11
PsiBlast_PDB
84.05
98%
-133
- C3 -
4A4V
1
PPARG_HUMAN
A:
[13-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
160
PsiBlast_CBE
83.93
98%
-137
- C3 -
2FVJ
2
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
66
PsiBlast_CBE
83.87
98%
-137
- C3 -
3OSW
2
PPARG_HUMAN
A:
[14-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
134
PsiBlast_CBE
83.75
98%
-136
- C3 -
3V9V
1
PPARG_HUMAN
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
155
PsiBlast_CBE
83.65
98%
-133
- C3 -
2HWQ
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
151
PsiBlast_CBE
83.61
98%
-136
- C3 -
3FEJ
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
150
PsiBlast_CBE
83.57
98%
-137
- C3 -
3G9E
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
156
PsiBlast_CBE
83.51
98%
-135
- C3 -
2GTK
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
63
PsiBlast_CBE
83.51
98%
-136
- C3 -
3VN2
1
PPARG_HUMAN
A:
[15-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
----------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
107
PsiBlast_CBE
83.50
98%
-136
- C3 -
2Q5S
1
PPARG_HUMAN
A:
[5-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
184
PsiBlast_CBE
83.34
98%
-136
* C3 *
3ET0
1
PPARG_HUMAN
A:
[22-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
10
PsiBlast_PDB
83.27
98%
-132
- C3 -
2YFE
1
PPARG_HUMAN
A:
[12-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
32
PsiBlast_CBE
83.26
98%
-130
- C3 -
3VSO
1
PPARG_HUMAN
A:
[15-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
---------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
58
PsiBlast_CBE
83.19
98%
-133
- C3 -
3PBA
1
PPARG_HUMAN
A:
[13-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
98
PsiBlast_CBE
83.17
98%
-138
- C3 -
2OM9
3
PPARG_HUMAN
B:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
-----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
154
PsiBlast_CBE
83.14
98%
-135
- C3 -
2HWR
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
7
PsiBlast_PDB
83.13
98%
-128
- C3 -
3ADW
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
146
PsiBlast_CBE
83.08
98%
-127
- C3 -
3NOA
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
99
PsiBlast_CBE
83.08
98%
-125
- C3 -
2OM9
3
PPARG_HUMAN
A:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
136
PsiBlast_CBE
83.04
98%
-126
- C3 -
3LMP
1
PPARG_HUMAN
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-------
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
161
PsiBlast_CBE
83.05
98%
-126
- C3 -
2F4B
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
75
PsiBlast_CBE
83.04
98%
-134
- C3 -
3R5N
2
PPARG_HUMAN
A:
[4-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
--
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
---------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
----
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
97
PsiBlast_CBE
82.98
98%
-126
- C3 -
2OM9
2
PPARG_HUMAN
C:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
105
PsiBlast_CBE
82.88
98%
-135
- C3 -
2Q61
1
PPARG_HUMAN
A:
[6-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
45
PsiBlast_CBE
82.83
98%
-128
- C3 -
2ZK6
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
96
PsiBlast_CBE
82.82
98%
-136
- C3 -
2OM9
2
PPARG_HUMAN
D:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
-----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
56
PsiBlast_CBE
82.82
98%
-134
- C3 -
3PO9
1
PPARG_HUMAN
A:
[13-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
133
PsiBlast_CBE
82.80
98%
-132
- C3 -
3V9Y
1
PPARG_HUMAN
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
52
PsiBlast_CBE
82.80
98%
-127
- C3 -
2ZK2
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
163
PsiBlast_CBE
82.79
98%
-125
- C3 -
2ATH
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
33
PsiBlast_CBE
82.75
98%
-133
- C3 -
3VJH
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
132
PsiBlast_CBE
82.71
98%
-131
- C3 -
4F9M
1
PPARG_HUMAN
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
137
PsiBlast_CBE
82.69
98%
-131
- C3 -
3B1M
1
PPARG_HUMAN
A:
[12-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
158
PsiBlast_CBE
82.70
98%
-125
- C3 -
2G0H
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
167
PsiBlast_CBE
82.67
98%
-141
- C3 -
4HEE
1
PPARG_HUMAN
X:
[14-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
91
PsiBlast_CBE
82.69
98%
-134
- C3 -
2VST
1
PPARG_HUMAN
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
67
PsiBlast_CBE
82.67
98%
-132
- C3 -
3OSI
1
PPARG_HUMAN
A:
[14-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
31
PsiBlast_CBE
82.67
98%
-129
- C3 -
3VSP
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
---------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
122
PsiBlast_CBE
82.65
98%
-135
- C3 -
3FUR
1
PPARG_HUMAN
A:
[1-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
----------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
18
PsiBlast_PDB
82.65
98%
-131
- C3 -
2I4J
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
111
PsiBlast_CBE
82.60
98%
-133
- C3 -
4R6S
1
PPARG_HUMAN
A:
[1-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
F
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
38
PsiBlast_CBE
82.58
98%
-129
- C3 -
3CDP
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
116
PsiBlast_CBE
82.55
98%
-132
- C3 -
4CI5
1
PPARG_HUMAN
A:
[1-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
174
PsiBlast_CBE
82.54
98%
-131
- C3 -
3CWD
1
PPARG_HUMAN
A:
[1-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
-------------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
182
PsiBlast_CBE
82.46
98%
-133
- C3 -
3U9Q
1
PPARG_HUMAN
A:
[208-476]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
159
PsiBlast_CBE
82.46
98%
-128
- C3 -
2G0G
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
181
PsiBlast_CBE
82.45
98%
-130
- C3 -
4Y29
1
?
A:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
131
PsiBlast_CBE
82.42
98%
-124
- C3 -
2HFP
2
PPARG_HUMAN
A:
[11-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
93
PsiBlast_CBE
82.41
98%
-133
- C3 -
2VSR
2
PPARG_HUMAN
A:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
95
PsiBlast_CBE
82.37
98%
-132
- C3 -
3SZ1
2
PPARG_HUMAN
A:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
47
PsiBlast_CBE
82.37
98%
-126
- C3 -
2ZK5
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
19
PsiBlast_PDB
82.35
98%
-126
- C3 -
2I4P
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
83
PsiBlast_CBE
82.33
98%
-138
- C3 -
2VV4
1
PPARG_HUMAN
A:
[4-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
--
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
8
PsiBlast_PDB
82.33
98%
-127
- C3 -
3ADX
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
6
PsiBlast_PDB
82.32
98%
-132
- C3 -
3ADV
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
175
PsiBlast_CBE
82.30
98%
-134
- C3 -
2Q59
1
PPARG_HUMAN
A:
[4-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
3
PsiBlast_PDB
82.28
98%
-132
- C3 -
3ADS
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
129
PsiBlast_CBE
82.25
98%
-137
- C3 -
3S9S
1
PPARG_HUMAN
A:
[15-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
34
PsiBlast_CBE
82.26
98%
-131
- C3 -
3HOD
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
65
PsiBlast_CBE
82.25
97%
-128
- C3 -
2ZVT
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
S
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
149
PsiBlast_CBE
82.20
98%
-125
- C3 -
3GBK
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
148
PsiBlast_CBE
82.20
98%
-132
- C3 -
3IA6
1
PPARG_HUMAN
A:
[1-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
157
PsiBlast_CBE
82.17
98%
-127
- C3 -
2G0H
1
PPARG_HUMAN
B:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
72
PsiBlast_CBE
82.17
98%
-128
- C3 -
1ZEO
1
PPARG_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
--------
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
20
PsiBlast_PDB
82.14
98%
-128
- C3 -
2I4Z
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
62
PsiBlast_CBE
82.12
98%
-135
- C3 -
1I7I
1
PPARG_HUMAN
A:
[22-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
87
PsiBlast_CBE
82.06
98%
-132
- C3 -
2VV1
1
PPARG_HUMAN
A:
[5-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
135
PsiBlast_CBE
82.04
98%
-133
- C3 -
3V9T
1
PPARG_HUMAN
A:
[12-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
--
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
30
PsiBlast_CBE
82.03
98%
-131
- C3 -
3WMH
1
PPARG_HUMAN
A:
[15-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
120
PsiBlast_CBE
82.00
98%
-133
- C3 -
3K8S
1
PPARG_HUMAN
A:
[2-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
----
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
----
L
H
P
L
L
Q
E
I
Y
K
D
L
-
74
PsiBlast_CBE
82.01
98%
-131
- C3 -
3BC5
1
PPARG_HUMAN
A:
[22-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
---
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
--
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
40
PsiBlast_CBE
82.00
98%
-129
- C3 -
3AN4
1
PPARG_HUMAN
A:
[15-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
117
PsiBlast_CBE
81.99
98%
-133
- C3 -
3KMG
1
PPARG_HUMAN
D:
[3-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
187
HHSearch
81.98
98%
-133
- C3 -
3U9Q
1
PPARG_HUMAN
A:
[210-475]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
173
PsiBlast_CBE
81.95
98%
-129
- C3 -
3CWD
1
PPARG_HUMAN
B:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
---------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
119
PsiBlast_CBE
81.93
98%
-129
- C3 -
3K8S
2
PPARG_HUMAN
B:
[2-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
108
PsiBlast_CBE
81.88
98%
-133
- C3 -
2Q5P
1
PPARG_HUMAN
A:
[4-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
118
PsiBlast_CBE
81.86
98%
-135
- C3 -
3KMG
1
PPARG_HUMAN
A:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
--------
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
5
PsiBlast_PDB
81.86
98%
-134
- C3 -
3ADU
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
121
PsiBlast_CBE
81.85
98%
-122
- C3 -
3H0A
1
PPARG_HUMAN
D:
[1-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-------
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
41
PsiBlast_CBE
81.78
98%
-129
- C3 -
3AN3
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
124
PsiBlast_CBE
81.76
98%
-133
- C3 -
2POB
1
PPARG_HUMAN
A:
[2-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
4
PsiBlast_PDB
81.76
98%
-131
- C3 -
3ADT
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
49
PsiBlast_CBE
81.75
98%
-124
- C3 -
2ZK4
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
86
PsiBlast_CBE
81.71
98%
-132
- C3 -
2VV2
1
PPARG_HUMAN
A:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
54
PsiBlast_CBE
81.71
98%
-125
- C3 -
2ZK1
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
36
PsiBlast_CBE
81.71
98%
-130
- C3 -
3D6D
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
84
PsiBlast_CBE
81.68
98%
-131
- C3 -
2VV3
1
PPARG_HUMAN
A:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
-
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
82
PsiBlast_CBE
81.66
98%
-133
- C3 -
3X1H
1
PPARG_HUMAN
A:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
69
PsiBlast_CBE
81.64
98%
-126
- C3 -
4R2U
1
PPARG_HUMAN
A:
[3-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
--
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
9
PsiBlast_PDB
81.60
98%
-126
- C3 -
3R8I
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
37
PsiBlast_CBE
81.56
98%
-130
- C3 -
3CDS
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
162
PsiBlast_CBE
81.54
98%
-120
- C3 -
2ATH
1
PPARG_HUMAN
B:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
152
PsiBlast_CBE
81.50
98%
-135
- C3 -
2Q8S
1
PPARG_HUMAN
A:
[1-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
12
PsiBlast_PDB
81.42
98%
-125
- C3 -
4E4K
2
PPARG_HUMAN
A:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
89
PsiBlast_CBE
81.40
98%
-131
- C3 -
2VV0
1
PPARG_HUMAN
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
35
PsiBlast_CBE
81.29
98%
-128
- C3 -
3HO0
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
21
PsiBlast_CBE
81.26
98%
-130
- C3 -
4A4W
1
PPARG_HUMAN
B:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
94
PsiBlast_CBE
81.22
98%
-133
- C3 -
3SZ1
2
PPARG_HUMAN
B:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
--
L
H
P
L
L
Q
E
I
Y
K
D
L
-
80
PsiBlast_CBE
81.22
98%
-134
- C3 -
3X1I
1
PPARG_HUMAN
A:
[5-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
104
PsiBlast_CBE
81.20
98%
-128
- C3 -
2Q61
1
PPARG_HUMAN
B:
[4-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
--
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
--
H
P
L
L
Q
E
I
Y
K
D
L
-
22
PsiBlast_CBE
81.20
98%
-130
- C3 -
4A4V
1
PPARG_HUMAN
B:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
144
PsiBlast_CBE
81.17
98%
-123
- C3 -
3QT0
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
140
PsiBlast_CBE
81.13
97%
-133
- C3 -
3WJ5
1
PPARG_HUMAN
A:
[4-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
109
PsiBlast_CBE
81.13
98%
-135
- C3 -
2Q59
1
PPARG_HUMAN
B:
[4-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
---------
H
P
L
L
Q
E
I
Y
K
D
--
142
PsiBlast_CBE
81.10
97%
-132
- C3 -
3WJ4
1
PPARG_HUMAN
A:
[4-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
51
PsiBlast_CBE
81.10
98%
-121
- C3 -
2ZK3
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
115
PsiBlast_CBE
81.09
98%
-137
- C3 -
4CI5
1
PPARG_HUMAN
B:
[2-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
180
PsiBlast_CBE
81.06
98%
-127
- C3 -
4FGY
1
PPARG_HUMAN
A:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-----
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
43
PsiBlast_CBE
81.04
98%
-127
- C3 -
2ZNO
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
--------
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
39
PsiBlast_CBE
80.95
98%
-125
- C3 -
3B3K
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
179
PsiBlast_CBE
80.80
98%
-128
- C3 -
4PRG
1
PPARG_HUMAN
A:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
145
PsiBlast_CBE
80.79
98%
-122
- C3 -
3NOA
1
PPARG_HUMAN
B:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
15
PsiBlast_PDB
80.70
98%
-123
- C3 -
4JL4
1
PPARG_HUMAN
A:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
13
PsiBlast_PDB
80.69
98%
-127
- C3 -
4E4Q
1
PPARG_HUMAN
A:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
28
PsiBlast_CBE
80.66
98%
-128
- C3 -
2YFE
1
PPARG_HUMAN
B:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
----
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
-
L
H
P
L
L
Q
E
I
Y
K
---
106
PsiBlast_CBE
80.65
98%
-134
- C3 -
2Q5S
1
PPARG_HUMAN
B:
[4-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
-
L
H
P
L
L
Q
E
I
Y
K
D
L
-
14
PsiBlast_PDB
80.59
98%
-121
- C3 -
4JAZ
1
PPARG_HUMAN
A:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
141
PsiBlast_CBE
80.24
97%
-132
- C3 -
3WJ4
1
PPARG_HUMAN
B:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
---
H
P
L
L
Q
E
I
Y
K
D
--
147
PsiBlast_CBE
80.19
98%
-135
- C3 -
3IA6
1
PPARG_HUMAN
B:
[1-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
---------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
---
102
PsiBlast_CBE
80.14
98%
-131
- C3 -
2Q6R
1
PPARG_HUMAN
B:
[4-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
-----
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
17
PsiBlast_PDB
79.99
98%
-129
- C3 -
4PWL
1
PPARG_HUMAN
A:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
92
PsiBlast_CBE
79.93
98%
-133
- C3 -
2VSR
1
PPARG_HUMAN
B:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
------
H
P
L
L
Q
E
I
Y
K
---
90
PsiBlast_CBE
79.92
98%
-135
- C3 -
2VST
1
PPARG_HUMAN
B:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
----
K
H
I
T
------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
------
H
P
L
L
Q
E
I
Y
K
---
114
PsiBlast_CBE
79.82
98%
-135
- C3 -
2VV4
1
PPARG_HUMAN
B:
[5-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-
T
T
D
K
S
P
F
V
I
Y
D
M
Q
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
-------
P
L
L
Q
E
I
Y
K
---
55
PsiBlast_CBE
79.70
98%
-137
- C3 -
3PO9
5
PPARG_HUMAN
B:
[16-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
-----
H
P
L
L
Q
E
I
Y
K
D
L
Y
29
PsiBlast_CBE
79.67
98%
-133
- C3 -
3WMH
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
----
101
PsiBlast_CBE
79.58
98%
-134
- C3 -
2Q6S
1
PPARG_HUMAN
B:
[4-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
---------
H
P
L
L
Q
E
I
Y
K
D
--
110
PsiBlast_CBE
79.51
98%
-133
- C3 -
4R6S
1
PPARG_HUMAN
B:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
F
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
---
85
PsiBlast_CBE
79.51
98%
-130
- C3 -
2VV2
2
PPARG_HUMAN
B:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-----
P
L
L
Q
E
I
Y
K
---
88
PsiBlast_CBE
79.46
98%
-133
- C3 -
2VV0
1
PPARG_HUMAN
B:
[7-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
L
-
113
PsiBlast_CBE
79.39
98%
-127
- C3 -
4OJ4
1
PPARG_HUMAN
A:
[8-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
--
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
---------
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
M
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
81
PsiBlast_CBE
79.37
98%
-131
- C3 -
3X1H
1
PPARG_HUMAN
B:
[7-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
------
H
P
L
L
Q
E
I
Y
K
---
24
PsiBlast_CBE
79.27
98%
-130
- C3 -
3ADW
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
123
PsiBlast_CBE
79.21
98%
-136
- C3 -
2POB
1
PPARG_HUMAN
B:
[1-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
--------------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
---
L
H
P
L
L
Q
E
I
Y
K
---
170
PsiBlast_CBE
79.19
98%
-127
- C3 -
4L98
2
PPARG_HUMAN
B:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
L
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
112
PsiBlast_CBE
79.14
98%
-141
- C3 -
2VV1
1
PPARG_HUMAN
B:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
-----------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
-------
P
L
L
Q
E
I
Y
----
183
PsiBlast_CBE
79.13
98%
-129
- C3 -
3ET0
1
PPARG_HUMAN
B:
[22-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
169
PsiBlast_CBE
78.93
98%
-124
- C3 -
3R8A
1
PPARG_HUMAN
A:
[12-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
-------
68
PsiBlast_CBE
78.91
98%
-127
- C3 -
4R2U
1
PPARG_HUMAN
D:
[6-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
-----
H
P
L
L
Q
E
I
Y
K
D
--
42
PsiBlast_CBE
78.88
98%
-128
- C3 -
2ZNO
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
---
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
---------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
26
PsiBlast_CBE
78.80
98%
-124
- C3 -
3ADU
3
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
--
S
L
H
P
L
L
Q
E
I
Y
----
172
PsiBlast_CBE
78.76
98%
-126
- C3 -
4L96
1
PPARG_HUMAN
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
L
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
100
PsiBlast_CBE
78.66
98%
-137
- C3 -
3B0R
1
PPARG_HUMAN
B:
[5-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
---
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
-------
H
P
L
L
Q
E
I
Y
----
25
PsiBlast_CBE
78.62
98%
-132
- C3 -
3ADV
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
---
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
---
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
23
PsiBlast_CBE
78.47
98%
-130
- C3 -
3ADX
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
---------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
177
PsiBlast_CBE
78.45
98%
-119
- C3 -
4PRG
1
PPARG_HUMAN
C:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
50
PsiBlast_CBE
78.41
98%
-127
- C3 -
2ZK3
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
61
PsiBlast_CBE
78.37
98%
-128
- C3 -
1I7I
1
PPARG_HUMAN
B:
[22-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
--
S
L
H
P
L
L
Q
E
I
Y
----
64
PsiBlast_CBE
78.35
97%
-127
- C3 -
2ZVT
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
S
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
139
PsiBlast_CBE
78.31
97%
-128
- C3 -
3WJ5
1
PPARG_HUMAN
B:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
-----
H
P
L
L
Q
E
I
Y
K
D
--
27
PsiBlast_CBE
78.14
98%
-133
- C3 -
3ADS
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
---------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
53
PsiBlast_CBE
78.13
98%
-126
- C3 -
2ZK1
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
178
PsiBlast_CBE
77.96
98%
-120
- C3 -
4PRG
1
PPARG_HUMAN
B:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
168
PsiBlast_CBE
77.95
98%
-136
- C3 -
3R8A
1
PPARG_HUMAN
B:
[12-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
------------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
----------
H
P
L
L
Q
E
I
Y
K
D
--
48
PsiBlast_CBE
77.83
98%
-123
- C3 -
2ZK4
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
44
PsiBlast_CBE
77.79
98%
-126
- C3 -
2ZK6
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
---
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
--
S
L
H
P
L
L
Q
E
I
Y
----
176
PsiBlast_CBE
77.68
98%
-118
- C3 -
4PRG
1
PPARG_HUMAN
D:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
46
PsiBlast_CBE
77.68
98%
-123
- C3 -
2ZK5
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
79
PsiBlast_CBE
77.27
98%
-139
- C3 -
3X1I
1
PPARG_HUMAN
B:
[9-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
-----------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
--------
P
L
L
Q
E
I
Y
----
171
PsiBlast_CBE
76.09
98%
-127
- C3 -
4L98
2
PPARG_HUMAN
A:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
--------------------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
L
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
103
PsiBlast_CBE
74.02
98%
-129
- C3 -
2Q6R
1
PPARG_HUMAN
A:
[4-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
----
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
-----------------
P
L
L
Q
E
I
Y
K
D
L
-
188
HHSearch
71.90
61%
-124
- C3 -
3VI8
1
PPARA_HUMAN
A:
[7-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
---
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y