@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK9_HUMAN: (2013-07-19 )
MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF
Atome Classification :
(99 SA)
.........10........20..-......30........--40........50........60........70........80........90........100.......110..-.------....120.......130.......140.......150.....----..-160.......170.......180..-.....190.......200.......210.......220..-----------..-...230.-------.----.....240.......250.....-------..260...---.-.----.---.270.-.--......280--.......290.......300.......310....--...320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAKQYDSVECPFCDEVSKYEKLA-KIGQGTFGEVFKARHR--KTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL-S------NVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLI----TR-DGVLKLADFGLARAFSLAKNSQPNR-YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-----------RS-PIMQGNT-------E----QHQLALISQLCGSITPEVWPNVD-------NYELYEKL---E-L----V---KGQ-K-R--KVKDRLKAY--VRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFW--SDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF
4
PsiBlast_PDB
95.50
99%
-125
- C1 -
3MIA
1
CDK9_HUMAN
A:
[8-340]
-------
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
-
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
--
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
--------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
-
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
----
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
P
N
R
-
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
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W
G
A
G
C
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A
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T
-----------
R
S
-
P
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Q
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N
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
-------
N
Y
E
L
Y
E
K
L
---
E
-
L
----
V
---
K
G
Q
-
K
-
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--
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A
Y
--
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A
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F
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W
--
S
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P
M
P
S
D
L
K
G
M
L
S
T
H
L
T
S
M
F
E
Y
L
A
--------------------------------
13
PsiBlast_PDB
95.07
99%
-131
- C1 -
4BCG
2
CDK9_HUMAN
A:
[8-328]
------
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
-
K
I
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E
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F
K
A
R
H
R
--
K
T
G
Q
K
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A
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K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
--------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
-
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
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L
Y
Y
I
H
R
N
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L
H
R
D
M
K
A
A
N
V
L
I
----
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
P
N
R
-
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
-----------
R
S
-
P
I
M
Q
G
N
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
-------
N
Y
E
L
Y
E
K
L
---
E
-
L
----
V
---
K
G
Q
-
K
-
R
--
K
V
K
D
R
L
K
A
Y
--
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
--
S
D
P
M
P
S
D
L
K
G
M
---------------------------------------------
5
PsiBlast_PDB
94.87
99%
-136
- C1 -
3BLQ
1
CDK9_HUMAN
A:
[8-326]
------
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
-
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
--
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
----------
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
-
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
----
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
-------
N
R
-
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
-----------
R
S
-
P
I
M
Q
G
N
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
-------
N
Y
E
L
Y
E
K
L
---
E
-
L
----
V
-------------
V
K
D
R
L
K
A
Y
--
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
--
S
D
P
M
P
S
D
L
K
-----------------------------------------------
7
PsiBlast_PDB
92.99
99%
-123
- C1 -
3MY1
3
CDK9_HUMAN
A:
[7-328]
-----
D
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
-
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
--
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
K
-------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
-
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
----
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
K
N
S
Q
P
N
R
-
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
-----------
R
S
-
P
I
M
Q
G
N
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
-------
N
Y
E
L
Y
E
K
L
---
E
-
L
----
V
---
K
G
Q
-
K
-
R
--
K
V
K
D
R
L
K
A
Y
--
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
--
S
D
P
M
P
S
D
L
K
G
M
---------------------------------------------
8
PsiBlast_PDB
92.51
99%
-129
- C1 -
3LQ5
1
CDK9_HUMAN
A:
[7-328]
-----
D
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
-
K
I
G
Q
--
F
G
E
V
F
K
A
R
H
R
--
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
--------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
-
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
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I
L
H
R
D
M
K
A
A
N
V
L
I
----
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
----
P
N
R
-
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
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D
Y
G
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D
L
W
G
A
G
C
I
M
A
E
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T
-----------
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S
-
P
I
M
Q
G
N
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
-------
N
Y
E
L
Y
E
K
L
---
E
-
L
----
V
---
K
G
Q
-
K
-
R
--
K
V
K
D
R
L
K
A
Y
--
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
--
S
D
P
M
P
S
D
L
K
G
M
---------------------------------------------
12
PsiBlast_PDB
92.14
99%
-126
- C1 -
4BCJ
1
CDK9_HUMAN
A:
[7-327]
-----
D
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
-
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
--
K
T
G
Q
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A
L
K
K
V
L
M
E
N
E
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E
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F
P
I
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A
L
R
E
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I
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Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
K
-------
K
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
-
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
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L
H
R
D
M
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A
A
N
V
L
I
----
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
----
P
N
R
-
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
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I
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L
W
G
A
G
C
I
M
A
E
M
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-----------
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S
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I
M
Q
G
N
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-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
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E
V
W
P
N
V
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-------
N
Y
E
L
Y
E
K
L
---
E
-
L
----
V
---
K
G
Q
-
K
-
R
--
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K
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R
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K
A
Y
--
V
R
D
P
Y
A
L
D
L
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D
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L
L
V
L
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A
Q
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D
A
L
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D
F
F
W
--
S
D
P
M
P
S
D
L
K
G
----------------------------------------------
6
PsiBlast_PDB
92.10
99%
-128
- C1 -
3BLR
1
CDK9_HUMAN
A:
[8-327]
------
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
-
K
I
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E
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F
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A
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H
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--
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Q
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N
E
K
E
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F
P
I
T
A
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R
E
I
K
I
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Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
----------
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
-
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
----
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
----
P
N
R
-
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
-----------
R
S
-
P
I
M
Q
G
N
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
-------
N
Y
E
L
Y
E
K
L
---
E
-
L
----
V
---
K
---------
V
K
D
R
L
K
A
Y
--
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
--
S
D
P
M
P
S
D
L
K
G
----------------------------------------------
11
PsiBlast_PDB
92.06
99%
-127
- C1 -
4BCI
1
CDK9_HUMAN
A:
[6-327]
----
Y
D
S
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
-
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
--
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
---------
G
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
-
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
----
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
A
----
P
N
R
-
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
-----------
R
S
-
P
I
M
Q
G
N
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
-------
N
Y
E
L
Y
E
K
L
---
E
-
L
----
V
---
K
G
Q
-
K
-
R
--
K
V
K
D
R
L
K
A
Y
--
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
--
S
D
P
M
P
S
D
L
K
G
----------------------------------------------
9
PsiBlast_PDB
91.47
99%
-136
- C1 -
3TNH
1
CDK9_HUMAN
A:
[9-329]
-------
V
E
C
P
F
C
D
E
V
S
K
Y
E
K
L
A
-
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
--
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
H
E
N
V
V
N
L
I
E
I
C
R
T
----------
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
-
S
------
N
V
L
V
K
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
----
T
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
-------
N
R
-
Y
T
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
-----------
R
S
-
P
I
M
Q
G
N
T
-------
E
----
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
-------
N
------------------------------
K
V
K
D
R
L
K
A
Y
--
V
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
--
S
D
P
M
P
S
D
L
K
G
M
L
--------------------------------------------
131
HHSearch
66.83
41%
-113
- C1 -
3NIZ
1
?
A:
[19-307]
--------------
L
M
E
K
Y
Q
K
L
E
-
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
---
Q
G
R
I
V
A
L
K
R
I
R
------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
H
S
E
--------
R
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
-
D
------
E
N
K
T
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
S
-
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
----
P
V
R
----
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-----------
G
K
-
P
L
F
P
G
V
T
-------
D
----
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
-------
E
L
P
L
W
K
Q
R
---
T
-
F
----
Q
---
V
F
E
-
K
-
K
--
P
W
S
S
I
I
P
G
F
----
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
--
D
L
------------------------------------------------------
81
PsiBlast_CBE
66.53
39%
-112
- C1 -
3R8P
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
122
HHSearch
66.45
31%
-103
- C1 -
3N9X
2
?
A:
[24-373]
--------------
V
P
D
N
Y
I
I
K
H
-
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
K
--
N
T
E
K
N
V
A
I
K
K
V
N
R
M
F
E
D
L
I
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
K
S
D
Y
I
I
R
L
Y
D
L
I
I
P
D
D
L
L
---
K
F
D
E
L
Y
I
V
L
E
I
A
D
S
D
L
K
K
L
F
-
K
------
T
P
-
I
F
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
----
N
Q
-
D
C
S
V
K
V
C
D
F
G
L
A
R
T
I
--------------
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
N
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
-
P
L
F
P
G
S
S
CFPH
E
K
S
N
----
R
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
E
D
D
L
K
N
I
N
-------
K
P
E
V
I
K
Y
I
---
K
L
F
----
P
---
H
R
K
-
P
-
I
--
N
L
K
Q
K
Y
P
S
I
----
S
D
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
--
D
V
R
K
K
K
L
-------------------------------------------------
84
PsiBlast_CBE
66.39
39%
-111
- C1 -
3R83
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
85
PsiBlast_CBE
66.35
39%
-112
- C1 -
3R7Y
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
91
PsiBlast_CBE
66.18
39%
-111
- C1 -
3R71
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
53
PsiBlast_CBE
66.18
39%
-112
- C1 -
3S0O
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
--
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
78
PsiBlast_CBE
66.11
39%
-113
- C1 -
3R8Z
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
---------
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
59
PsiBlast_CBE
66.03
39%
-111
- C1 -
3RPO
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
72
PsiBlast_CBE
65.79
39%
-109
- C1 -
3RAI
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
89
PsiBlast_CBE
65.76
39%
-112
- C1 -
3R7E
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
96
PsiBlast_CBE
65.59
39%
-109
- C1 -
3R1Q
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
54
PsiBlast_CBE
65.58
39%
-110
- C1 -
3S00
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
98
PsiBlast_CBE
65.51
39%
-109
- C1 -
3QZH
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
26
PsiBlast_CBE
65.44
40%
-117
- C1 -
1V0P
1
CDC2H_PLAFK
A:
[1-284]
---------------
M
E
K
Y
H
G
L
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
---
Y
G
E
T
F
A
L
K
K
I
R
L
E
K
E
D
E
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
T
K
K
R
--------
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
-
D
------
V
C
E
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
--------------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-----------
G
T
-
P
L
F
P
G
V
S
-------
E
----
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
ELPKYDP
N
F
T
V
Y
E
P
L
P
W
E
S
-
F
----
L
---
K
G
-------------------
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
-----------------------------------------------------------
51
PsiBlast_CBE
65.36
39%
-106
- C1 -
3SQQ
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
------
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
94
PsiBlast_CBE
65.29
39%
-110
- C1 -
3R1Y
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
63
PsiBlast_CBE
65.27
39%
-113
- C1 -
3RM7
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
79
PsiBlast_CBE
65.26
39%
-111
- C1 -
3R8V
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
95
PsiBlast_CBE
65.22
39%
-109
- C1 -
3R1S
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
73
PsiBlast_CBE
65.15
39%
-112
- C1 -
3RAH
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
92
PsiBlast_CBE
65.14
39%
-108
- C1 -
3R6X
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
97
PsiBlast_CBE
65.09
39%
-110
- C1 -
3QZI
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
23
PsiBlast_CBE
65.09
40%
-118
- C1 -
1V0O
1
CDC2H_PLAFK
B:
[3-284]
-----------------
K
Y
H
G
L
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
---
Y
G
E
T
F
A
L
K
K
I
R
L
----------
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
T
K
K
R
--------
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
-
D
------
V
C
E
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
----
V
R
K
-
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-----------
G
T
-
P
L
F
P
G
V
S
-------
E
----
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
ELPKYDP
N
F
T
V
Y
E
P
L
P
W
E
S
-
F
----
L
---
K
G
-------------------
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
-----------------------------------------------------------
102
PsiBlast_CBE
65.01
39%
-109
- C1 -
3QXO
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
86
PsiBlast_CBE
64.99
39%
-109
- C1 -
3R7V
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
93
PsiBlast_CBE
64.95
39%
-109
- C1 -
3R28
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
88
PsiBlast_CBE
64.83
39%
-112
- C1 -
3R7I
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
58
PsiBlast_CBE
64.82
39%
-112
- C1 -
3RPR
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
57
PsiBlast_CBE
64.78
39%
-109
- C1 -
3RPV
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
90
PsiBlast_CBE
64.71
39%
-109
- C1 -
3R73
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
80
PsiBlast_CBE
64.71
39%
-108
- C1 -
3R8U
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
50
PsiBlast_CBE
64.71
39%
-110
- C1 -
4EZ3
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
100
PsiBlast_CBE
64.68
39%
-108
- C1 -
3QZF
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
60
PsiBlast_CBE
64.59
39%
-108
- C1 -
3ROY
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
75
PsiBlast_CBE
64.56
39%
-111
- C1 -
3R9N
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
69
PsiBlast_CBE
64.50
39%
-113
- C1 -
3RJC
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
76
PsiBlast_CBE
64.49
39%
-111
- C1 -
3R9H
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
22
PsiBlast_CBE
64.45
41%
-112
- C1 -
4AU8
2
CDK5_HUMAN
B:
[7-293]
-----------------
K
Y
E
K
L
E
-
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
R
L
----
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
S
-
K
--------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
-
D
------
S
C
N
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
-----
P
V
------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
-----------
A
G
R
P
L
F
P
G
N
D
-------
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
-------
K
L
P
D
Y
K
P
Y
---
P
-
M
----
Y
---
P
A
T
-
T
-
S
LV
N
V
V
P
K
L
N
A
T
--
G
R
-----
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
---
S
D
F
-----------------------------------------------------
99
PsiBlast_CBE
64.38
39%
-110
- C1 -
3QZG
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
83
PsiBlast_CBE
64.37
39%
-111
- C1 -
3R8L
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
87
PsiBlast_CBE
64.30
39%
-111
- C1 -
3R7U
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
77
PsiBlast_CBE
64.29
39%
-106
- C1 -
3R9D
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
24
PsiBlast_CBE
64.26
40%
-115
- C1 -
1V0O
1
CDC2H_PLAFK
A:
[3-284]
-----------------
K
Y
H
G
L
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
---
Y
G
E
T
F
A
L
K
K
I
R
L
--------
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
T
K
K
R
--------
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
-
D
------
V
C
E
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
----
V
R
K
-
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-----------
G
T
-
P
L
F
P
G
V
S
-------
E
----
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
ELPKYDP
N
F
T
V
Y
E
P
L
PWE
S
-
F
----
L
---
K
G
-------------------
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
-----------------------------------------------------------
39
PsiBlast_CBE
64.08
39%
-103
- C1 -
2BKZ
1
CDK2_HUMAN
C:
[5-299]
-------------
D
-
M
E
N
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
40
PsiBlast_CBE
63.89
39%
-102
- C1 -
2BKZ
1
CDK2_HUMAN
A:
[2-299]
----------
P
L
V
D
-
M
E
N
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
36
PsiBlast_CBE
63.85
39%
-100
- C1 -
2C4G
1
CDK2_HUMAN
A:
[2-299]
----------
P
L
V
D
-
M
E
N
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
74
PsiBlast_CBE
63.79
39%
-109
- C1 -
3R9O
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
71
PsiBlast_CBE
63.78
39%
-111
- C1 -
3RAK
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
68
PsiBlast_CBE
63.75
39%
-110
- C1 -
3RK5
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
34
PsiBlast_CBE
63.70
39%
-101
- C1 -
2WIH
1
CDK2_HUMAN
A:
[2-299]
----------
P
L
V
D
-
M
E
N
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
38
PsiBlast_CBE
63.66
39%
-101
- C1 -
2BPM
1
CDK2_HUMAN
A:
[2-299]
----------
P
L
V
D
-
M
E
N
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
66
PsiBlast_CBE
63.58
39%
-108
- C1 -
3RK9
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
29
PsiBlast_CBE
63.53
39%
-104
- C1 -
2WPA
1
CDK2_HUMAN
C:
[5-299]
-------------
D
-
M
E
N
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
62
PsiBlast_CBE
63.49
39%
-111
- C1 -
3RMF
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
19
PsiBlast_PDB
63.41
39%
-105
- C1 -
3EZR
2
CDK2_HUMAN
A:
[3-296]
---------------
M
E
N
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-
D
A
-----
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
K
P
----
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
----
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
67
PsiBlast_CBE
63.39
39%
-110
- C1 -
3RK7
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
70
PsiBlast_CBE
63.38
39%
-111
- C1 -
3RAL
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
42
PsiBlast_CBE
63.37
39%
-102
- C1 -
1VYW
1
CDK2_HUMAN
A:
[2-299]
----------
P
L
V
D
-
M
E
N
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
48
PsiBlast_CBE
63.27
39%
-107
- C1 -
4GCJ
5
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
35
PsiBlast_CBE
63.25
39%
-104
- C1 -
2C4G
1
CDK2_HUMAN
C:
[4-299]
------------
V
D
-
M
E
N
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
44
PsiBlast_CBE
63.23
40%
-112
- C1 -
1UNL
1
CDK5_HUMAN
A:
[1-291]
---------------
M
Q
K
Y
E
K
L
E
-
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
S
D
K
--------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
-
D
------
S
C
N
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
-----
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
-----------
A
G
R
P
L
F
P
G
N
D
-------
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
-------
K
L
P
D
Y
K
P
Y
---
P
-
M
----
Y
---
P
A
T
-
T
-
S
LV
N
V
V
P
K
L
N
A
T
--
G
R
-----
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
---
S
D
F
C
P
---------------------------------------------------
27
PsiBlast_CBE
63.22
39%
-105
- C1 -
2WXV
1
CDK2_HUMAN
C:
[5-299]
-------------
D
-
M
E
N
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
30
PsiBlast_CBE
63.18
39%
-101
- C1 -
2WPA
1
CDK2_HUMAN
A:
[2-299]
----------
P
L
V
D
-
M
E
N
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
65
PsiBlast_CBE
63.02
39%
-110
- C1 -
3RKB
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
37
PsiBlast_CBE
63.00
39%
-105
- C1 -
2BPM
1
CDK2_HUMAN
C:
[5-299]
-------------
D
-
M
E
N
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
32
PsiBlast_CBE
62.93
39%
-106
- C1 -
2WIP
1
CDK2_HUMAN
A:
[2-299]
----------
P
L
V
D
-
M
E
N
F
Q
K
V
E
-
K
I
G
-----
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
28
PsiBlast_CBE
62.91
39%
-101
- C1 -
2WXV
1
CDK2_HUMAN
A:
[2-299]
----------
P
L
V
D
-
M
E
N
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
55
PsiBlast_CBE
62.81
39%
-111
- C1 -
3RZB
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
133
HHSearch
62.75
42%
-97
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-310]
-------------------
E
K
L
D
-
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
--
N
T
N
Q
I
V
A
I
K
K
I
---------
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
I
I
G
L
L
D
A
F
G
H
K
--------
S
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
-
K
------
D
N
S
L
V
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
----
D
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
----
P
N
R
A
-
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-----------
R
V
-
P
F
L
P
G
D
S
-------
D
----
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
-------
S
L
P
D
Y
V
T
F
---
K
-
S
----
F
---
P
G
----
I
--
P
L
H
H
I
F
S
A
A
----
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
--
N
R
P
G
P
T
P
G
C
Q
L
P
R
P
------------------------------------------
56
PsiBlast_CBE
62.72
39%
-112
- C1 -
3RPY
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
82
PsiBlast_CBE
62.66
39%
-105
- C1 -
3R8M
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
101
PsiBlast_CBE
62.56
39%
-108
- C1 -
3QXP
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
52
PsiBlast_CBE
62.55
39%
-111
- C1 -
3S1H
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
31
PsiBlast_CBE
62.54
39%
-107
- C1 -
2WIP
1
CDK2_HUMAN
C:
[5-299]
-------------
D
-
M
E
N
F
Q
K
V
E
-
K
I
G
-----
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
61
PsiBlast_CBE
62.53
39%
-105
- C1 -
3RNI
1
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
41
PsiBlast_CBE
62.45
39%
-107
- C1 -
1VYW
1
CDK2_HUMAN
C:
[5-299]
-------------
D
-
M
E
N
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
20
PsiBlast_PDB
62.32
39%
-101
- C1 -
3EZV
1
CDK2_HUMAN
A:
[3-296]
---------------
M
E
N
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
-
D
A
-----
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
K
P
----
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
----
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
33
PsiBlast_CBE
62.00
39%
-106
- C1 -
2WIH
1
CDK2_HUMAN
C:
[5-299]
-------------
D
-
M
E
N
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
64
PsiBlast_CBE
61.83
39%
-103
- C1 -
3RM6
2
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
47
PsiBlast_CBE
61.68
40%
-117
- C1 -
1UNG
1
CDK5_HUMAN
A:
[1-291]
---------------
M
Q
K
Y
E
K
L
E
-
K
I
----
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
S
D
K
--------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
-
D
------
S
C
N
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
-----
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
-----------
A
G
R
P
L
F
P
G
N
D
-------
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
-------
K
L
P
D
Y
K
P
Y
---
P
-
M
----
Y
---
P
A
T
-
T
-
S
LV
N
V
V
P
K
L
N
A
T
--
G
R
-----
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
---
S
D
F
C
P
---------------------------------------------------
17
PsiBlast_PDB
61.38
41%
-106
- C1 -
4AU8
2
CDK5_HUMAN
A:
[7-293]
-----------------
K
Y
E
K
L
E
-
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
--
E
T
H
E
I
V
A
L
K
R
V
---------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
-----------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
-
D
------
S
C
N
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
-----
P
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
-----------
A
G
R
P
L
F
P
G
N
D
-------
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
-------
K
L
P
D
Y
K
P
Y
---
P
-
M
----
Y
---
P
A
T
-
T
-
S
LV
N
V
V
P
K
L
N
A
T
--
G
R
-----
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
---
S
D
F
-----------------------------------------------------
25
PsiBlast_CBE
61.33
40%
-123
- C1 -
1V0P
1
CDC2H_PLAFK
B:
[2-284]
----------------
E
K
Y
H
G
L
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
---
Y
G
E
T
F
A
L
K
-----------
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
T
-----------
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
-
D
------
V
C
E
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
------------------
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-----------
G
T
-
P
L
F
P
G
V
S
-------
E
----
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
ELPKYDP
N
F
T
V
Y
E
P
L
P
W
E
S
-
F
----
L
---
K
G
-------------------
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
-----------------------------------------------------------
124
HHSearch
61.04
36%
-113
- C1 -
4F6U
10
CDK8_HUMAN
A:
[19-346]
---------------
E
D
L
F
E
Y
E
G
C
K
V
G
R
G
T
Y
G
H
V
Y
K
A
K
R
K
DG
K
D
D
K
D
Y
A
L
K
Q
I
E
----
G
T
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
A
D
------
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
-
K
F
H
R
A
S
K---
V
Q
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
EG
P
E
-
R
G
R
V
K
I
A
D
M
G
F
-------------------
V
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-----------
S
E
-
P
I
F
H
C
R
Q
-------
E
NPYH
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
-------
K
M
P
E
H
S
T
L
---
M
-
K
----
D
F
RR
N
T
Y
-
T
N
C
--
S
L
I
K
Y
M
E
K
H
KV
K
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
--
E
D
P
L
P
T
S
D
------------------------------------------------
49
PsiBlast_CBE
60.79
39%
-100
- C1 -
4EZ7
7
CDK2_HUMAN
A:
[12-302]
------------------
F
Q
K
V
E
-
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
--
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--------
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
------
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
T
-----
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
-
A
L
F
P
G
D
S
-------
E
----
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
-------
S
M
P
D
Y
-
K
P
---
S
-
F
----
P
---
K
W
A
-
R
-
Q
--
D
F
S
K
V
V
P
P
L
--
D
E
D
--
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
V
P
---------------------------------------------------
116
HHSearch
60.12
35%
-105
- C1 -
3ZDU
3
CDKL3_HUMAN
A:
[2-292]
---------------
M
E
M
Y
E
T
L
G
-
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
--
N
T
G
Q
I
V
A
I
K
I
F
Y
--------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
H
E
N
L
V
N
L
I
E
V
F
R
Q
K
--------
K
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
E
L
-
Q
------
H
Y
C
H
G
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
----
S
Q
-
S
G
I
T
K
L
C
D
F
G
F
A
R
T
---------
D
I
-
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
-----------
G
N
-
P
Y
L
P
S
S
S
-------
D
----
L
D
L
L
H
K
I
V
L
K
V
G
N
L
S
P
H
L
Q
N
I
F
S
-------
K
S
P
I
F
A
G
V
---
V
-
L
----
P
---
Q
V
Q
H
P
-
K
--
N
A
R
K
K
Y
P
K
L
----
N
G
L
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
--
R
D
G
F
----------------------------------------------------
43
PsiBlast_CBE
59.66
40%
-118
- C1 -
3O0G
1
CDK5_HUMAN
B:
[6-288]
--------------------
K
L
E
-
K
I
G
-----
T
V
F
K
A
--------
E
I
V
A
L
K
R
V
R
--------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
S
D
K
--------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
-
D
------
S
C
N
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
----
N
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
-----
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
-----------
A
G
R
P
L
F
P
G
N
D
-------
V
----
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
-------
K
L
P
D
Y
K
P
Y
---
P
-
M
----
Y
---
P
A
T
-
T
-
S
LV
N
V
V
P
K
L
N
A
T
--
G
R
-----
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
---
S
D
------------------------------------------------------
125
HHSearch
58.01
36%
-115
- C1 -
3RGF
5
CDK8_HUMAN
A:
[19-346]
---------------
E
D
L
F
E
Y
E
G
C
K
V
G
-----
H
V
Y
K
A
K
R
K
DG
K
D
D
K
D
Y
A
L
K
Q
I
E
----
G
T
G
I
S
M
S
A
C
R
E
I
A
L
L
R
E
L
K
H
P
N
V
I
S
L
Q
K
V
F
L
S
H
A
D
------
R
K
V
W
L
L
F
D
Y
A
E
H
D
L
W
H
I
I
-
K
F
H
R
A
S
K-----
L
P
R
G
M
V
K
S
L
L
Y
Q
I
L
D
G
I
H
Y
L
H
A
N
W
V
L
H
R
D
L
K
P
A
N
I
L
V
M
G
EG
P
E
-
R
G
R
V
K
I
A
D
M
G
F
A
R
------------------
V
T
F
W
Y
R
A
P
E
L
L
L
G
A
R
H
Y
T
K
A
I
D
I
W
A
I
G
C
I
F
A
E
L
L
T
-----------
S
E
-
P
I
F
H
C
R
Q
--------NPYH
H
D
Q
L
D
R
I
F
N
V
M
G
F
P
A
D
K
D
W
E
D
I
K
-------
K
M
P
E
H
S
T
L
---
M
-
K
D
F
RR
N
---
T
Y
T
-
N
-
C
--
S
L
I
K
Y
M
E
K
H
KV
K
P
D
S
K
A
F
H
L
L
Q
K
L
L
T
M
D
P
I
K
R
I
T
S
E
Q
A
M
Q
D
P
Y
F
L
--
E
D
P
L
P
T
S
D
------------------------------------------------
132
HHSearch
56.63
30%
-107
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[51-343]
-------------
P
Q
E
V
S
Y
T
D
T
K
-
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
--
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
R
------
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
--
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
-
R
H
Y
S
---
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
----
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
-----
E
P
-
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
-
P
I
F
P
G
D
S
-------
G
----
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
---------
N
P
N
Y
T
E
F
---
K
-
F
----
P
---
Q
I
K
-
A
-
H
--
P
W
T
K
V
F
R
P
R
--
T
-
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
--
E
L
------------------------------------------------------
129
HHSearch
53.24
33%
-109
- C1 -
2FST
3
MK14_HUMAN
X:
[28-323]
---------------
P
E
R
Y
Q
N
L
S
-
P
V
G
----
G
S
V
C
A
A
F
D
T
--
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
--
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
------------
Q
--
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
----
N
E
-
D
C
E
L
K
I
L
D
-----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
-
T
L
F
P
G
T
D
-------
H
----
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
I
S
-------
S
E
S
A
R
N
Y
I
Q--
S
-
L
----
T
---
Q
M
P
-
K
-
M
--
N
F
A
N
V
F
I
G
A
----
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
--
Q
Y
H
D
P
D
D
-------------------------------------------------