@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CLK4_HUMAN: (2013-07-19 )
MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK
Atome Classification :
(15 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.----.---.....200.--......210.......220.......230-----.......240-.......250.......260.......270.......280........290.......300..------.....310.......320.......---330...-....340.......350-.-......360.......370-----------.......380------........390.......400....---...410.--......420.....--..----430.......440.......450.......460...-----....470.......480
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKN----V---GRYREAARS--EIQVLEHLNSTDPNSVFRCVQMLEWFDHH-----GHVCIVFELL-GLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHN-KLTHTDLKPENILFVKSDYVVKYN------SKMKRDERTLKNTDIKVVDFGSATY---DDEHHS-TLVSTRHYRAPEVILAL-G-WSQPCDVWSIGCILIEYYL-----------GFTVFQTHD-------SKEHLAMMERILGPIPQHMIQKTRK---RKYFHHN--QLDWDEHSSAGRYV--RR----RCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRIT-----LDEALQHPFFDLLKKK
35
HHSearch
91.12
86%
-120
- C1 -
1Z57
1
CLK1_HUMAN
A:
[1-337]
-----------------------------------------------------------------------------------------------------------------------------------------------
S
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K
K
-
2
PsiBlast_PDB
90.45
86%
-125
- C1 -
2VAG
1
CLK1_HUMAN
A:
[3-336]
-------------------------------------------------------------------------------------------------------------------------------------------------
H
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K
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Y
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---------
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---
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-------
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L
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F
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D
L
L
K
--
22
PsiBlast_CBE
89.05
66%
-118
- C1 -
3NR9
1
CLK2_HUMAN
B:
[15-354]
------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
A
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A
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A
L
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N
----
V
---
E
K
Y
K
E
A
A
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--
E
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------
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----
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L
G
E
A
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P
F
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A
R
L
---
3
PsiBlast_PDB
89.03
66%
-120
- C1 -
3NR9
1
CLK2_HUMAN
A:
[15-356]
------------------------------------------------------------------------------------------------------------------------------------------
V
E
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D
A
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----
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A
A
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-
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R
A
-
21
PsiBlast_CBE
88.30
66%
-119
- C1 -
3NR9
1
CLK2_HUMAN
C:
[15-355]
------------------------------------------------------------------------------------------------------------------------------------------
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----
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A
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R
--
4
PsiBlast_PDB
86.61
62%
-117
- C1 -
2WU6
7
CLK3_HUMAN
A:
[31-369]
----------------------------------------------------------------------------------------------------------------------------------------
R
S
V
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-
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-----------
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-------
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R
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V
M
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M
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---
Q
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Y
F
Y
K
G
--
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
--
K
E
----
N
C
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P
L
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M
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S
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Q
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M
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E
F
D
P
A
Q
R
I
T
-----
L
A
E
A
L
L
H
P
F
F
------
6
PsiBlast_PDB
85.60
62%
-115
- C1 -
3RAW
1
CLK3_HUMAN
A:
[31-369]
----------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
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E
R
Y
E
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G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
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A
R
G
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S
Q
V
A
L
K
I
I
R
N
----
V
---
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
-----
G
H
M
C
I
A
F
E
L
L
-
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
------
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
---
D
H
E
H
H
T
-
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
-
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
-----------
G
F
T
L
F
Q
T
H
E
-------
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
---
Q
K
Y
F
Y
K
G
--
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
--
K
E
----
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
-----
L
A
E
A
L
L
H
P
F
F
------
23
PsiBlast_CBE
84.62
62%
-114
- C1 -
3RAW
1
CLK3_HUMAN
B:
[33-369]
------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
----
V
---
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
-----
G
H
M
C
I
A
F
E
L
L
-
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
------
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
---
D
H
E
H
H
T
-
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
-
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
-----------
G
F
T
L
F
Q
T
H
E
-------
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
---
Q
K
Y
F
Y
K
G
--
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
--
K
E
----
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
-----
L
A
E
A
L
L
H
P
F
F
------
5
PsiBlast_PDB
83.45
62%
-117
- C1 -
2WU7
1
CLK3_HUMAN
A:
[32-369]
-----------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
----
V
---
G
K
Y
R
E
A
A
R
L
--
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
F
H
-----
G
H
M
C
I
A
F
E
L
L
-
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
V
N
S
E
F
E
T
L
Y
N
------
E
H
K
S
C
E
E
K
S
V
K
N
T
S
I
R
V
A
D
F
G
S
A
T
F
---
D
H
E
H
H
T
-
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
-
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
-----------
G
F
T
L
F
Q
T
H
E
-------
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
---
Q
K
Y
F
Y
K
G
--
G
L
V
W
D
E
N
S
S
D
G
R
Y
V
--
K
E
----
N
C
K
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
-----
L
A
E
A
L
L
H
P
F
F
------
40
HHSearch
68.42
37%
-115
- C1 -
3LLT
1
?
A:
[20-360]
---------------------------------------------------------------------------------------------------------------------------------------------
D
E
I
V
H
F
S
W
K
K
G
M
L
L
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
I
-
D
N
K
K
Y
Y
A
V
K
V
V
R
N
----
I
---
K
K
Y
T
R
S
A
K
I
--
E
A
D
I
L
K
K
I
Q
N
D
D
I
N
N
N
N
-
I
V
K
Y
H
G
K
F
M
Y
Y
-----
D
H
M
C
L
I
F
E
P
L
-
G
P
S
L
Y
E
I
I
T
R
N
N
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
K
M
-
S
L
T
H
T
D
L
K
P
E
N
I
L
L
D
D
P
Y
F
E
K
S
L
I
T
V
R
R
VT
D
G
K
K
I
Q
I
Y
R
T
K
S
T
G
I
K
L
I
D
F
G
C
A
T
F
---
K
S
D
Y
H
G
-
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
L
-
G
-
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
-----------
G
S
L
L
F
R
T
H
E
-------
H
M
E
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
Y
E
A
T
K
T
NG
S
K
Y
V
N
K
D
EL
K
L
A
W
P
E
N
A
S
S
I
N
S
I
K
H
V
K
----
K
C
L
P
L
Y
K
I
I
-----
K
H
E
L
F
C
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
-----
P
A
E
L
L
K
H
K
F
L
E
-----
52
HHSearch
60.78
30%
-123
- C1 -
3N9X
2
?
A:
[23-370]
---------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
P
D
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
K
-
N
T
E
K
N
V
A
I
K
K
V
N
R
----
M
FED
L
I
D
C
K
R
I
L
R
--
E
I
T
I
L
N
R
L
K
S
--
D
Y
----
I
I
R
L
Y
D
L
I
I
P
D
DLLKF
D
E
L
Y
I
V
L
E
I
A
-
D
S
D
L
K
K
L
F
K
T
P
I
--
F
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
-
G
I
I
H
R
D
L
K
P
A
N
C
L
L
N
-------------------------
Q
D
C
S
V
K
V
C
D
F
G
L
A
R
T
---
I
-------
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
N
-
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
P
L
F
P
G
S
S
CFPH
E
K
S
N
R
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
E
D
D
L
K
N
I
N
K
---
P
E
----------------
V
I
K
Y
I
--
K
L
F
P
H
R
K
P
I
N
L
K
Q
K
Y
P
S
I
---
S
D
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
-----
I
D
Q
A
L
D
H
P
Y
L
K
D
V
R
K
-
17
PsiBlast_PDB
56.43
30%
-108
- C1 -
2B9I
1
FUS3_YEAST
A:
[9-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
-
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
E
P
----
F
---
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
-
I
Q
R
P
D
S
F
E
N
F
-----
N
E
V
Y
I
I
Q
E
L
M
-
Q
T
D
L
H
R
V
I
S
T
Q
M
L
---
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
-
N
V
I
H
R
D
L
K
P
S
N
L
L
I
---------
N
------
S
----------
N
C
D
L
K
V
C
D
F
G
L
A
R
I
---
I
D
E
---V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
-
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
-----------
R
R
P
I
F
P
G
R
D
-------
Y
R
H
Q
L
L
L
I
F
G
I
I
G
-
T
P
H
S
---------------
D
N
--
D
L
R
C
I
E
S
P
R
A
R
E
Y
I
--
K
S
LPMY
P
A
A
P
L
E
K
M
F
---
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
-----
A
K
E
A
L
E
H
P
Y
L
------
18
PsiBlast_PDB
55.33
30%
-107
- C1 -
2B9J
1
FUS3_YEAST
A:
[9-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
-
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
E
P
----
F
---
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
-
I
Q
R
P
D
S
F
E
N
F
-----
N
E
V
Y
I
I
Q
E
L
M
-
Q
T
D
L
H
R
V
I
S
T
Q
M
L
---
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
-
N
V
I
H
R
D
L
K
P
S
N
L
L
I
---------
N
------
S
----------
N
C
D
L
K
V
C
D
F
G
L
A
R
I
---
I
D
----V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
-
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
-----------
R
R
P
I
F
P
G
R
D
-------
Y
R
H
Q
L
L
L
I
F
G
I
I
G
-
T
P
H
S
---------------
D
N
--
D
L
R
C
I
E
S
P
R
A
R
E
Y
I
--
K
S
LPMY
P
A
A
P
L
E
K
M
F
---
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
-----
A
K
E
A
L
E
H
P
Y
L
------
16
PsiBlast_PDB
54.13
30%
-108
- C1 -
2B9H
1
FUS3_YEAST
A:
[9-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
-
V
V
C
S
A
T
H
K
P
T
G
E
I
V
A
I
K
K
I
E
P
----
F
---
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
-
I
Q
R
P
D
S
F
E
N
F
-----
N
E
V
Y
I
I
Q
E
L
M
-
Q
T
D
L
H
R
V
I
S
T
Q
M
L
---
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
-
N
V
I
H
R
D
L
K
P
S
N
L
L
I
---------
N
------
S
----------
N
C
D
L
K
V
C
D
F
G
L
A
R
I
---
I
D
----V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
-
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
-----------
R
R
P
I
F
P
G
R
D
-------
Y
R
H
Q
L
L
L
I
F
G
I
I
G
-
T
P
H
S
---------------
D
N
--
D
L
R
C
I
E
S
P
R
A
R
E
Y
I
--
K
S
LPMY
P
A
A
P
L
E
K
M
F
---
P
R
V
N
P
K
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
-----
A
K
E
A
L
E
H
P
Y
L
------
59
HHSearch
52.97
31%
-135
* C1 *
4GV1
5
AKT1_HUMAN
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
-
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
---
K
D
E
V
A
H
T
L
T
--
E
N
R
V
L
Q
N
S
R
H
--
P
---
F
-
L
T
A
L
K
Y
S
F
Q
T
H
-----
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
--
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
-------------------------
D
G
H
I
K
I
T
D
F
G
L
C
K
E
GIK
D
G
A
T
M
K
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
-----------
G
R
L
P
F
Y
N
Q
D
-------
H
E
---
K
L
F
E
L
I
L
M
---------------------
E
--
E
I
R
F
P
R
T
L
------------------------
G
-----
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
---