@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0105: (2016-03-12 )
MKKLFSITSVVLLVLSLVVVSIGAEPKRAKAAENVPQYRNVMYYGDWSIWGGEGNFYPKDIPADQLTHLNFAFLDFNSNGDLVFTDKDAAVGAPVGQEGVQWGGANAGVLNAIQDLRAQNPNLKIGVSVGGWSKSGDFSTVAADPTKRANFVKNVMKFVKYTNMDFVDLDWEYPASVRDADLVDNKNDEGTPNAKPADKQNFITLLQDLRTALDKQGVDINKKYELSVALPAAKSTLENGIDVANLFKVVDFANVMTYDLNGAWTPNSAHHTALYGNPKDPNYDSGFSVDQTVKYLKEKGAVSNKIVVGAAFYTRGWNKVAAGTDTALPGLFQAAEKTNKDADGSLTYGANNENPIKTGDGGRAGGVWAYRSIDALKAKTPTLKEYWDDTAKAPYLYSKETGEFYTYDNTRSIGYKAQYVKDNNLGGMISWMQSQDKTTTSTKRDELTKAIKTGLFGTSAIPQNAITYANLNVVATVKPYSENGVGYEITITNNEKADETNEVLKSTELSFETVKLPKFYIPVKAGETLTAGDYKAGTVTTSGGNTVVDLASVYDAQQIPQGASYTFRLKSSASSVDVANISKIDLTQRMVKSSVEFGKQTIFGGGTVVPDPSDTEAPTVPKALASSNVTDKSATLTWTASTDNKAVAGYKVYRNGTEVGSVSGTTFTDSGLTAKTAYTYTVKAYDAAGNFSAASSALTVTTLDAATPPATPAWDAAKTYNKGDRVSYKGKTYEAQWWTQGNEPGAEQWGPWLLIN
Atome Classification :
(21 SA)
-------------------------------------------------.......-----..10.....--------...20........30....----....40........50-------.-.-.......60-...----.....----70........-80----------.-...-----------------.-------------------..---------..90...--...--------------..-------100-----------...---.---...--------..110.......120.......130..-.-------....140..-------.....150.......160.----------------.-.-.....170.......-180.......190.......200.......210.......--220.---.--.---......230......-.-240.-.......-250.......260....-..-.270.......280---.---------------..----------------------.....-------.290..-...-..-300.......310.......320---........330.......340.......-350......--..360.......370.......-----380...-----....390.......400.......410.......420.......430.......440.---..-......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------M
K
K
L
F
S
I
-----
T
S
V
V
L
L
V
L
S
--------
L
V
V
V
SIGAEPKR
A
K
A
A
ENV----PQYR
N
V
M
Y
YG
D
W
S
I
W--------G-G-EGNFYPKDI-PAD----QLTH
L
----
N
F
A
F
L
D
FNSN-G-----------
D
-
L
V
F
-----------------T-------------------DK---------DAAVGAP--VGQ--------------EG-------V-------------QWG---G---AN
A
--------
G
V
L
N
A
I
Q
D
L
RAQNP
N
L
K
I
G
V
S
VGGWSK-S-------GDFSTVAAD-------
P
T
K
R
A
N
F
V
K
N
V
M
K
F
V
K-YT----------------N-M-
D
F
V
DLDWEYPASVRD-ADLVDNKNDEGTPNAKPA
D
K
Q
N
F
I
T
L
L
Q
D
L
R
T
A
L
D
KQGVD--I--N---
K
--
K
---
Y
E
L
S
V
ALP
A
A
K
S
T
L
E-N-G-I
D
-
V
A
N
L
F
K
V
-
V
D
F
A
N
V
M
T
YDLNGAWTP-NS-AHHTALYGNPKD-----P---------------NY----------------------DSGF
S
-------
V
D
Q
T
V
K
-
Y
L
K
-
E
K-GAVSN
K
I
V
V
G
A
A
F
YTRGWNKVA----AGTD
T
A
L
P
G
L
F
Q
A
A
E
KTNKDADG
S
L
T
YG-AN-NENPIK--TGDGGRAGG
V
W
A
Y
RSI
D
A
LKAK-----T
P
T
L
K
E
-----
Y
W
DDTAKA
P
Y
L
Y
SKETG
E
F
Y
TYDNTRSIG
Y
K
A
Q
Y
V
KDNNL
G
G
M
I
S
W
M
Q
SQDKTTT--S---
T
K
-
R
D
E
L
T
K
A
I
K
TGLFGTSAIPQN
A
I
T
Y
A
N
L
N
V
V
A
T
VKPYSENGV
G
Y
E
I
T
ITNNEKA
D
E
T
N
E
V
L
K
STEL
S
F
E
T
V
KL
P
K
F
Y
I
P
VKAG
E
T
LTAGDYKA
G
T
V
TTSGG
N
T
V
V
D
L
A
S
VY
D
A
Q
QIPQGA
S
Y
T
F
R
LKSSASSVD
V
A
NI
S
K
I
D
L
T
Q
R
M
V
K
S
S
V
E
FGK
Q
T
IFGGGTVVPDPSDTEAPTV
P
K
A
L
ASSNVTDK
S
A
T
L
T
W
T
ASTDNKA
V
A
G
Y
K
V
Y
RNGTEVGSVSG
T
T
FTDSG
L
T
A
K
T
A
Y
T
Y
T
V
K
A
YDAAGNFSAAS
S
A
L
T
V
T
T
LDAATPPATPAW
D
A
A
KTYNKGD
R
V
S
YKG
K
T
Y
E
A
Q
W
WTQGNEP
G
A
E
QWG
P
W
L
L
IN
24
HHSearch
85.91
31%
-49
- C1 -
1GOI
6
CHIB_SERMA
A:
[3-419]
-----------------------------------------------------------------------------------------------------
T
R
K
A
V
I
G
Y
Y
F
I
P
T
N
Q
I
N
N
YTETD
T
-
S
-
V
V
P
F
P
V
S
N
I
-
T
P
A
K
A
K
-
Q
L
T
H
I
----
N
F
S
F
L
D
I
N
S
N
-
L
-----------
E
-
C
A
W
-----------------
D
-------------------
P
A
---------
T
N
-------------------------------------------------
D
---
A
---
K
A
R
--------
D
V
V
N
R
L
T
A
L
K
A
H
N
P
S
L
R
I
M
F
S
I
G
G
W
Y
Y
-
S
NDLGVS
H
A
N
Y
V
N
A
V
K
T
-------
P
A
S
R
A
K
F
A
Q
S
C
V
R
I
M
K
-
D
Y
----------------
G
-
F
-
D
G
V
N
I
D
W
E
Y
P
Q
A
---------------------
A
E
V
D
G
F
I
A
A
L
Q
E
I
R
T
L
L
N
Q
Q
T
I
T
--
D
--
G
RQA
L
--
P
---
Y
Q
L
T
I
A
G
A
G
G
A
F
F
L
S
-
R
Y
Y
-
S
K
-
L
A
Q
I
V
A
P
-
L
D
Y
I
N
L
M
T
Y
D
L
A
G
P
W
E
K
-
V
T
-
N
H
Q
A
A
L
F
G
D
A
A
G
-----
P
---------------
T
F
Y
NALREANLGWS
W
E
E
L
T
R
A
F
PS
P
F
S
L
T
-------
V
D
A
A
V
Q
-
Q
H
L
M
M
E
-
G
V
P
S
A
K
I
V
M
G
V
P
F
Y
G
R
A
F
K
G
V
S
----
G
G
N
G
G
----
Q
Y
S
S
H
S
-----
T
P
G
E
D
P
Y
P
-
S
T
-
D
Y
W
L
V
G
C
E
E
C
V
R
D
K
D
P
R
I
A
S
Y
R
Q
L
E
Q
M
L
Q
G
-----
N
Y
G
Y
Q
R
-----
L
W
N
D
K
T
K
T
P
Y
L
Y
H
A
Q
N
G
L
F
V
T
Y
D
D
A
E
S
F
K
Y
K
A
K
Y
I
K
Q
Q
Q
L
G
G
V
M
F
W
H
L
G
Q
D
N
R
N
G
-----------
D
L
L
A
A
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
85.11
30%
-56
- C1 -
1VF8
-
CHIL3_MOUSE
A:
[1-371]
-------------------------------------------------------------------------------------------------------
Y
Q
L
M
C
Y
Y
T
S
W
A
K
D
--------
R
-
P
I
E
G
S
F
K
P
G
N
I
-
D
P
C
----
L
C
T
H
L
----
I
Y
A
F
A
G
M
Q
N
N
-
E
-------------
I
T
Y
-----------------
T
-------------------
H
E
--------------------------------------------------------------------
Q
D
L
--------
R
D
Y
E
A
L
N
G
L
K
D
K
N
T
E
L
K
T
L
L
A
I
G
G
W
K
F
-
G
P------
A
P
F
S
A
M
V
S
T
-------
P
Q
N
R
Q
I
F
I
Q
S
V
I
R
F
L
R
-
Q
Y
----------------
N
-
F
-
D
G
L
N
L
D
W
Q
Y
P
G
S
R
G
----------------
S
P
P
K
D
K
H
L
F
S
V
L
V
K
E
M
R
K
A
F
E
E
E
S
V
E
--
K
--
D
I--
P
--
R
---
L
L
L
T
S
T
G
A
G
I
I
D
V
I
K
-
S
-
G
-
Y
K
-
I
P
E
L
S
Q
S
-
L
D
Y
I
Q
V
M
T
Y
D
L
H
D
P
K
D
G
-
Y
T
-
G
E
N
S
P
L
Y
K
S
P
Y
D
-----
I
---------------
G
K
----------------------
S
A
D
L
N
-------
V
D
S
I
I
S
-
Y
W
K
-
D
H
-
G
A
A
S
E
K
L
I
V
G
F
P
A
Y
G
H
T
F
I
L
S
D
----
P
S
K
T
G
----
I
------------
G
A
P
T
I
S
-------
T
G
P
--
P
G
K
Y
T
D
E
S
G
L
L
A
Y
Y
E
V
C
T
F
L
N
-------
E
G
A
T
E
-----
V
W
D
A
P
Q
E
V
P
Y
A
Y
Q
--
G
N
E
W
V
G
Y
D
N
V
R
S
F
K
L
K
A
Q
W
L
K
D
N
N
L
G
G
A
V
V
W
P
L
D
M
D
D
F
S
G
SF
C
---
H
Q
R
H
F
P
L
T
S
T
L
K
G
D
L
N
I
H
S
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
85.01
31%
-58
- C1 -
1LL7
-
CHI1_COCPS
A:
[37-405]
------------------------------------------------------------------------------------------------------
G
F
R
S
V
V
Y
F
V
N
W
A
I
Y
------------
G
R
G
H
N
P
Q
D
L
-
K
A
D
----
Q
F
T
H
I
----
L
Y
A
F
A
N
I
R
P
S
-
G
-----------
E
-
V
Y
L
-----------------
S
-------------------
D
T
---------
W
A
D
T
D
K
H
--
Y
P
----------------
G
-------
D
-------------
K
W
D
EP
G
N
---
N
V
Y
--------
G
C
I
K
Q
M
Y
L
L
K
K
N
N
R
N
L
K
T
L
L
S
I
G
G
W
T
Y
-
S
-------
P
N
F
K
T
P
A
S
T
-------
E
E
G
R
K
K
F
A
D
T
S
L
K
L
M
K
-
D
L
----------------
G
-
F
-
D
G
I
D
I
D
W
Q
Y
P
E
D
--------------------
E
K
Q
A
N
D
F
V
L
L
L
K
A
C
R
E
A
L
D
A
Y
S
A
K
H
P
N
--
G
---
K
--
K
---
F
L
L
T
I
A
S
P
A
G
P
Q
N
Y
N
---
K
-
L
K
-
L
A
E
M
D
K
Y
-
L
D
F
W
N
L
M
A
Y
D
F
S
G
S
W
D
K
-
V
S
-
G
H
M
S
N
V
F
P
S
T
T
K
-----
P
---------------
E
-----------------------
S
T
P
F
S
-------
S
D
K
A
V
K
-
D
Y
I
-
K
A
-
G
V
P
A
N
K
I
V
L
G
M
P
L
Y
G
R
A
F
A
S
T
D
----
G
I
G
--------------------
T
S
F
N
G
------------
V
G
G
G
S
W
E
N
G
V
W
D
Y
K
D
M
P
Q
Q
----------
G
A
Q
V
-----
T
E
L
E
D
I
A
A
S
Y
S
Y
D
K
N
K
R
Y
L
I
S
Y
D
T
V
K
I
A
G
K
K
A
E
Y
I
T
K
N
G
M
G
G
G
M
W
W
E
S
S
S
D
K
T
G
----------
N
E
S
L
V
G
T
V
V
N
G
L
G
G
T
G
K
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
84.87
29%
-56
- C1 -
3G6M
2
?
A:
[19-386]
-----------------------------------------------------------------------------------------------------
T
G
S
I
N
A
V
Y
F
T
N
W
G
I
Y
------------
G
R
N
F
Q
P
A
D
L
-
Q
A
S
----
K
I
L
H
V
----
L
Y
S
F
M
N
L
R
V
D
-
G
-----------
T
-
V
Y
S
-----------------
G
-------------------
D
T
---------
Y
A
D
L
E
K
H
--
Y
S
D
-----------------------
D
-------------
S
W
N
---
D
I
G
T
N
A
Y
--------
G
C
V
K
Q
L
Y
K
L
K
K
A
N
R
S
L
K
I
M
L
S
I
G
G
W
T
W
-
S
-------
T
N
F
P
A
A
A
S
T
-------
E
A
T
R
A
T
F
A
K
T
A
V
E
F
M
K
-
D
W
----------------
G
-
F
-
D
G
I
D
V
D
W
E
Y
P
A
S
--------------------
E
T
D
A
N
N
M
V
L
L
L
Q
R
V
R
Q
E
L
D
S
Y
S
A
T
YA
N
--
G
---
Y
--
H
---
F
Q
L
S
I
A
A
P
A
G
P
S
H
Y
N
---
V
-
L
K
-
L
A
Q
L
G
S
V
-
L
D
N
I
N
L
M
A
Y
D
Y
A
G
S
W
D
S
-
V
S
-
G
H
Q
T
N
L
Y
P
S
T
S
N
-----
P
---------------
S
-----------------------
S
T
P
F
S
-------
T
K
A
A
V
D
-
A
Y
I
-
A
A
-
G
V
P
A
S
K
I
I
L
G
M
P
I
Y
G
R
A
F
V
G
T
D
----
G
P
G
--------------------
K
P
Y
S
T
------------
I
G
E
G
S
W
E
S
G
I
W
D
Y
K
V
L
P
K
----------
A
G
A
T
V
-----
I
T
D
S
A
A
G
A
T
Y
S
Y
D
S
S
S
R
T
M
I
S
Y
D
T
P
D
M
V
R
T
K
V
S
Y
A
K
G
L
G
L
G
G
S
M
F
W
E
A
S
A
D
K
T
G
----------
S
D
S
L
I
G
T
A
L
S
S
M
G
S
H
D
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
84.18
30%
-56
- C1 -
1W9P
3
CHIB1_ASPFM
A:
[39-413]
-----------------------------------------------------------------------------------------------
A
S
----
S
G
Y
R
S
V
V
Y
F
V
N
W
A
I
Y
------------
G
R
N
H
N
P
Q
D
L
-
P
V
E
----
R
L
T
H
V
----
L
Y
A
F
A
N
V
R
P
E
T
G
-----------
E
-
V
Y
M
-----------------
T
-------------------
D
S
---------
W
A
D
I
E
K
H
--
Y
P
----------------
G
-------
D
-------------
S
W
S
DTG
N
---
N
V
Y
--------
G
C
I
K
Q
L
Y
L
L
K
K
Q
N
R
N
L
K
V
L
L
S
I
G
G
W
T
Y
-
S
-------
P
N
F
A
P
A
A
S
T
-------
D
A
G
R
K
N
F
A
K
T
A
V
K
L
L
Q
-
D
L
----------------
G
-
F
-
D
G
L
D
I
D
W
E
Y
P
E
N
--------------------
D
Q
Q
A
N
D
F
V
L
L
L
K
E
V
R
T
A
L
D
S
Y
S
A
A
--
N
AG
G
---
Q
--
H
---
F
L
L
T
V
A
S
P
A
G
P
D
K
I
K
---
V
-
L
H
-
L
K
D
M
D
Q
Q
-
L
D
F
W
N
L
M
A
Y
D
Y
A
G
S
F
S
S
-
L
S
-
G
H
Q
A
N
V
Y
N
D
T
S
N
-----
P
---------------
L
-----------------------
S
T
P
F
N
-------
T
Q
T
A
L
D
-
L
Y
R
-
A
G
-
G
V
P
A
N
K
I
V
L
G
M
P
L
Y
G
R
S
F
A
N
T
D
----
G
P
G
--------------------
K
P
Y
N
G
-
V
-----------
G
Q
G
S
W
E
N
G
V
W
D
Y
K
A
L
P
Q
A
----------
G
A
T
E
-----
H
V
L
P
D
I
M
A
S
Y
S
Y
D
A
T
N
K
F
L
I
S
Y
D
N
P
Q
V
A
N
L
K
S
G
Y
I
K
S
L
G
L
G
G
A
M
W
W
D
S
S
S
D
K
T
G
----------
S
D
S
L
I
T
T
V
V
N
A
L
G
G
T
G
V
F
E
Q
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
83.61
28%
-54
- C1 -
3W4R
2
?
A:
[24-402]
------------------------------------------------------------------------------------------------------
R
A
R
V
V
C
Y
F
S
N
W
A
V
Y
R-------
P
-
G
-
V
G
R
Y
G
I
E
D
I
-
P
V
D
----
M
C
T
H
I
----
I
Y
S
F
I
G
V
T
E
D
-
T
-----------
Q
Q
V
L
I
-----------------
I
-------------------
D
P
------------------
E
L
D
-----------------------------------------------
V
D
K
--------
N
G
F
K
N
F
T
S
L
R
S
K
H
P
G
V
K
F
T
V
A
V
G
G
W
A
E
-
G
G------
S
K
Y
S
K
M
V
A
A
-------
K
S
T
R
M
A
F
V
R
S
V
V
D
F
L
N
-
K
Y
----------------
N
-
F
-
D
G
L
D
L
D
W
E
Y
P
G
A
A
D
R
--------------
G
G
S
F
S
D
K
D
K
F
L
Y
L
V
Q
E
L
R
R
A
F
I
R
E
G
-----------
K
--
G
---
W
E
L
T
A
A
V
P
L
A
N
F
R
L
M
-
E
-
G
-
Y
H
-
V
P
E
L
C
Q
E
-
L
D
A
I
H
V
M
S
Y
D
L
R
G
N
W
A
G
-
F
A
-
D
V
H
S
P
L
Y
K
R
P
H
D
-----
Q
---------------
W
A
----------------------
Y
E
K
L
N
-------
V
N
D
G
L
Q
-
L
W
E
-
D
K
-
G
C
P
T
N
K
L
V
V
G
I
P
F
Y
G
R
S
F
T
L
S
S
----
G
N
N
N
Y
N
----
L
-----------
G
T
Y
I
N
---
K
-
E
A
G
G
G
D
--
P
A
P
Y
T
N
A
T
G
F
W
A
Y
Y
E
I
C
T
E
V
D
T
A----
D
S
K
W
T
K
-----
K
W
D
E
H
G
K
C
P
Y
A
Y
K
--
G
T
Q
W
V
G
Y
E
D
P
R
S
V
E
I
K
M
N
W
I
K
E
K
G
Y
L
G
A
M
T
W
A
I
D
M
D
D
F
Q
G
L-
C
---
G
E
-
K
N
I
L
I
K
L
L
H
K
H
M
S
A
Y
T
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
83.02
29%
-36
- C1 -
3OA5
4
?
A:
[38-552]
KSNLIYDKDP
G
Y
V
W
DNKNECEG
A
A
E
E
T
Y
Q
E
L
NYEPSISADKLTWTPTRL
A
K
T
V
F
N
T
Y
EDDD
D
F
N
V
L
C
Y
F
T
DWSQYDPR
I
I
N
K
E
I
R
D
T
G
G
R
S
A
D
I
L
R
L
NTPD
G
R
P
F
K
R
L
I
Y
S
F
G
G
L
I
--------
G
-
D
-
K
K
Y
--
S
A
D
G
-
N
A
S
----
I
A
V
R
L
GVAT
D
P
D
D
A
I
A
N
H
K
-
G
-----------
K
-
T
I
P
-----------------
V
-------------------
D
P
---------
D
G
A
V
L
A
S
IN
C
G
F
--------------
T
K
-------
W
-------------
E
A
G
---
D
---
A
N
E
RYNQEKAK
G
L
L
G
G
F
R
L
L
H
E
A
D
K
E
L
E
F
S
L
S
I
G
G
W
S
M
-
S
-------
G
L
F
S
E
I
A
K
D
-------
E
I
L
R
T
N
F
V
E
G
I
K
D
F
F
Q
-
R
F
----------------
P
-
M
F
S
H
L
D
I
D
W
E
Y
P
G
S
-----------
I
G
A
G
N
P
N
-
S
P
D
D
G
A
N
F
A
I
L
I
Q
Q
I
T
D
A
K
I
S
N
L
------------------
K
G
I
S
I
A
S
S
A
D
P
A
K
I
D
-
A
-
A
--
N
-
I
P
A
L
M
D
A
G
V
T
G
I
N
L
M
T
Y
D
F
F
T
L
G
D
G
-
K
L
-
S
H
H
T
N
I
Y
R
D
P
S
D
-----
V
---------------------------------------
Y
S
K
Y
S
-------
I
D
D
A
V
T
-
H
L
I
-
D
E
K
K
V
D
P
K
A
I
F
I
G
Y
A
G
Y
T
R
N
A
K
N
A
T
ITTS
I
P
S
E
E
A
L
K
G
T
Y
T
D
A
N
Q
T
L
----
G
S
F
E
Y
S
-
V
L
-
E
------------
W
T
D
I
I
C
H
Y
M
D
F
E
K
G
E
G
R
------
N
G
Y
K
L
-----
V
H
D
K
V
A
K
A
D
Y
L
Y
S
E
A
T
K
V
F
I
S
L
D
T
P
R
S
V
R
D
K
G
R
Y
V
K
D
K
G
L
G
G
L
F
I
W
S
G
D
Q
D
N
-------------
G
I
L
T
N
A
A
H
E
G
L
--------------------------------------------------
K
R
R
I
K
N
K
V
I
D
M
T
P
F
Y
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
82.95
30%
-54
- C1 -
1E9L
1
CHIL3_MOUSE
A:
[1-372]
-------------------------------------------------------------------------------------------------------
Y
Q
L
M
C
Y
Y
T
S
W
A
K
D
--------
R
P
I
-
E
G
S
F
K
P
G
N
I
D-
P
C
----
L
C
T
H
L
----
I
Y
A
F
A
G
M
Q
-
N
-
N
-----------
E
-
I
T
Y
-----------------
T
-------------------
H
E
---------
Q
D
L
-------------------------------------------------------------------
R
D
Y
E
A
L
N
G
L
K
D
K
N
T
E
L
K
T
L
L
A
I
G
G
W
K
F
G
P
-------
A
P
F
S
A
M
V
S
T
-------
P
Q
N
R
Q
I
F
I
Q
S
V
I
R
F
L
R
Q
Y
-----------------
N
-
F
-
D
G
L
N
L
D
W
Q
Y
P
G
S
-----------
R
-----
G
S
P
P
K
D
K
H
L
F
S
V
L
V
K
E
M
R
K
A
F
E
E
E
S
V
E
--
K
--
D
----IP
R
---
L
L
L
T
S
T
G
A
G
I
I
D
V
I
K
-
S
-
G
Y-
K
-
I
P
E
L
S
Q
S
-
L
D
Y
I
Q
V
M
T
Y
D
L
H
D
P
K
D
--
G
Y
T
G
E
N
S
P
L
Y
K
S
P
Y
D
-----
I
--------------------------------------------GKSADLN
V
D
S
I
I
S
-
Y
W
K
-
D
H
-
G
A
A
S
E
K
L
I
V
G
F
P
A
Y
G
H
T
F
I
L
S
D
------
P
S
K
T
G
I
G
-----
A
P
T
I
S
T
G
----------------
P
--
P
G
K
Y
T
D
E
S
G
L
L
A
Y
Y
E
V
C
T
F
L
N
E
-------
G
A
T
E
-----
V
W
D
A
P
Q
E
V
P
Y
A
Y
Q
G
--
N
E
W
V
G
Y
D
N
V
R
S
F
K
L
K
A
Q
W
L
K
D
N
N
L
G
G
A
V
V
W
P
L
D
M
D
D
F
S
G
--
S
FCH
Q
R
-
H
F
P
L
T
S
T
L
K
G
D
L
N
----
I
H
S
-----------------
A
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
82.61
30%
-59
* C1 *
3FY1
3
CHIA_HUMAN
A:
[1-371]
-------------------------------------------------------------------------------------------------------
Y
Q
L
T
C
Y
F
T
N
W
A
Q
Y
R-------
P
-
G
-
L
G
R
F
M
P
D
D
I
-
N
P
C
----
L
C
T
H
L
----
I
Y
A
F
A
G
M
Q
N
N
-
E
-----------
I
-
T
T
I
-----------------
E
---------------------------------------
W
-------------------------------------------------
N
D
V
--------
T
L
Y
Q
A
F
N
G
L
K
N
K
N
S
Q
L
K
T
L
L
A
I
G
G
W
N
F
-
G
T------
A
P
F
T
A
M
V
S
T
-------
P
E
N
R
Q
T
F
I
T
S
V
I
K
F
L
R
-
Q
Y
----------------
E
-
F
-
D
G
L
D
F
D
W
E
Y
P
G
S
R
G
----------------
S
P
P
Q
D
K
H
L
F
T
V
L
V
Q
E
M
R
E
A
F
E
Q
E
A
K
Q
--
I
N-
K
---
P
--
R
---
L
M
V
T
A
A
V
A
A
G
I
S
N
I
Q
-
S
-
G
-
Y
E
-
I
P
Q
L
S
Q
Y
-
L
D
Y
I
H
V
M
T
Y
D
L
H
G
S
W
E
G
-
Y
T
-
G
E
N
S
P
L
Y
K
Y
P
T
D
-----
T
---------------
G
S
----------------------
N
A
Y
L
N
-------
V
D
Y
V
M
N
-
Y
W
K
-
D
N
-
G
A
P
A
E
K
L
I
V
G
F
P
T
Y
G
H
N
F
I
L
S
N
----
P
S
N
T
G
----
I
------------
G
A
P
T
S
G
-------
A
G
P
--
A
G
P
Y
A
K
E
S
G
I
W
A
Y
Y
E
I
C
T
F
L
K
-------
N
G
A
T
Q
-----
G
W
D
A
P
Q
E
V
P
Y
A
Y
Q
--
G
N
V
W
V
G
Y
D
N
V
K
S
F
D
I
K
A
Q
W
L
K
H
N
K
F
G
G
A
M
V
W
A
I
D
L
D
D
F
T
G
TF
C
N--
Q
G
-
K
F
P
L
I
S
T
L
K
K
A
L
G
L
Q
S
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.55
32%
-45
- C1 -
1ITX
11
CHIA1_BACCI
A:
[2-410]
--------------------------------------------------------------------------------------
Q
P
A
T
A
E
A
A
D
S
-------
Y
K
I
V
G
Y
Y
P
S
W
A
A
Y
--------
G
-
R
---
N
Y
N
V
A
D
I
-
D
P
T
----
K
V
T
H
I
----
N
Y
A
F
A
D
I
C
W
N
-
G
I
H
G
N
PDPSGPN
P
-
V
T
W
-----------------
T
CQN----------------
E
K
---------
S
Q
T
I
N
V
P
--
N
G
T
IVLGDPWIDTGKTF
A
G
-------
D
-------------
T
W
D
---
Q
---
P
I
A
--------
G
N
I
N
Q
L
N
K
L
K
Q
T
N
P
N
L
K
T
I
I
S
V
G
G
W
T
W
-
S
-------
N
R
F
S
D
V
A
A
T
-------
A
A
T
R
E
V
F
A
N
S
A
V
D
F
L
R
-
K
Y
----------------
N
-
F
-
D
G
V
D
L
D
W
E
Y
P
V
S
----
G
G
L
D
G
N
S
K
-------
R
P
E
D
K
Q
N
Y
T
L
L
L
S
K
I
R
E
K
L
D
A
A
G
A
V
--
D
--
G
---
K
--
K
---
Y
L
L
T
I
A
-
S
G
A
S
A
T
Y
A
-
A
-
N
-
T
E
-
L
A
K
I
A
A
I
-
V
D
W
I
N
I
M
T
Y
D
F
N
G
A
W
Q
K
-
I
S
-
A
H
N
A
P
L
N
Y
D
P
A
A
S
A
A
GV
P
---------------
D
A
----------------------
N
T
-
F
N
-------
V
A
A
G
A
Q
-
G
H
L
-
D
A
-
G
V
P
A
A
K
L
V
L
G
V
P
F
Y
G
R
G
W
D
--------
G
C
A
Q
A
G
N
G
Q
Y
Q
----------------------------
T
C
T
G
G
S
S
V
G
T
W
E
A
G
S
F
D
F
Y
D
L
E
-----
A
N
Y
I
N
K
NG
Y
T
R
Y
W
N
D
T
A
K
V
P
Y
L
Y
N
A
S
N
K
R
F
I
S
Y
D
D
A
E
S
V
G
Y
K
T
A
Y
I
K
S
K
G
L
G
G
A
M
F
W
E
L
S
G
D
R
N
K
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
80.88
29%
-50
- C1 -
1EDQ
-
?
A:
[154-560]
-----------------------------------------------------------------------------------------------
Q
N
----
S
G
K
V
V
G
S
Y
F
V
E
W
G
V
Y
------------
G
R
N
F
T
V
D
K
I
-
P
A
Q
----
N
L
T
H
L
----
L
Y
G
F
I
P
I
C
G
G
-
N
-----------
G
-
I
N
D
-----------------
S
LKEIEG
S
F
Q
A
L
Q
R
S
C
QGRE
D
F
---------
K
V
S
I
H
D
P
--
F
A
A
--------------
L
Q
-------
K
AQKGVT-------
A
W
D
---
D
---
P
Y
K
--------
G
N
F
G
Q
L
M
A
L
K
Q
A
H
P
D
L
K
I
L
P
S
I
G
G
W
T
L
-
S
-------
D
P
F
F
F
M
-
G
D
-------
K
V
K
R
D
R
F
V
G
S
V
K
E
F
L
Q
-
T
W
----------------
K
F
F
-
D
G
V
D
I
D
W
E
F
P
G
G
K
G
A
-
N
P
N
----------
L
G
S
P
Q
D
G
E
T
Y
V
L
L
M
K
E
L
R
A
M
L
D
Q
L
S
V
E
--
T
--
G
---
R
--
K
---
Y
E
L
T
S
A
I
S
A
G
K
D
K
I
D
---
K
-
V
A
-
Y
N
V
A
Q
N
S
-
M
D
H
I
F
L
M
S
Y
D
F
Y
G
A
F
D
L
K
N
L
-
G
H
Q
T
A
L
N
A
P
A
W
K
-----
P
---------------
D
------------------------
T
A
Y
T
-------
T
V
N
G
V
N
-
A
L
L
-
A
Q
-
G
V
K
P
G
K
I
V
V
G
T
A
M
Y
G
R
G
W
T
G
V
N
----
G
Y
Q
N
N
------------------
I
P
F
T
G
-
T
A
-----
T
G
--
P
V
K
G
T
W
E
N
G
I
V
D
Y
R
Q
I
A
G
Q
F
M
S
------
G
E
W
Q
Y
-----
T
Y
D
A
T
A
E
A
P
Y
V
F
K
P
S
T
G
D
L
I
T
F
D
D
A
R
S
V
Q
A
K
G
K
Y
V
L
D
K
Q
L
G
G
L
F
S
W
E
I
D
A
D
N
G
D
-------------
I
L
N
S
M
N
A
S
L
G
N
S
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
79.87
29%
-43
- C1 -
3ARX
2
?
A:
[135-573]
------------------------------------------------------------------------------------------------
D
----
P
S
I
V
M
G
T
Y
F
V
E
W
G
I
Y
------------
G
R
D
Y
T
V
D
N
M
-
P
V
D
----
N
L
T
H
I
----
L
Y
G
F
I
P
I
C
G
P
-
N
-----------
E
-
S
V
K
S
V
GGN
S
F
N
A
L
Q
T
A
C
RGV
N
-------------------
D
Y
---------
E
V
V
I
H
D
P
--
W
A
A
--------------
Y
Q
KSFPQAG
H
-------------
E
Y
S
---
T
---
P
I
K
--------
G
N
Y
A
M
L
M
A
L
K
Q
R
N
P
D
L
K
I
I
P
S
I
G
G
W
T
L
-
S
-------
D
P
F
Y
D
F
V
-
D
-------
K
K
N
R
D
T
F
V
A
S
V
K
K
F
L
K
-
T
W
----------------
K
-
F
Y
D
G
V
D
I
D
W
E
F
P
G
G
G
G
A
-
A
A
D
K
---------
G
D
P
V
N
D
G
P
A
Y
I
A
L
M
R
E
L
R
V
M
L
D
E
L
E
A
E
--
T
--
G
---
R
--
T
---
Y
E
L
T
S
A
I
G
V
G
Y
D
K
I
E
---
D
-
V
D
-
Y
A
D
A
V
Q
Y
-
M
D
Y
I
F
A
M
T
Y
D
F
Y
G
G
W
N
N
-
V
P
-
G
H
Q
T
A
L
Y
C
G
S
F
M
-----
R
PGQCDGGGVDENGEP
Y
K
----------------------
G
P
A
Y
T
-------
A
D
N
G
I
Q
-
L
L
L
-
A
Q
-
G
V
P
A
N
K
L
V
L
G
T
A
M
Y
G
R
G
W
E
G
V
T
----
P
D
T
L
T
---
D
------------
P
N
D
P
M
T
G
-
T
A
T
G
K
L
K
G
S
--
T
A
Q
G
V
W
E
D
G
V
I
D
Y
K
G
I
K
S
F
M
L
G
ANNTG
I
N
G
F
E
Y
-----
G
Y
D
A
Q
A
E
A
P
W
V
W
N
R
S
T
G
E
L
I
T
F
D
D
H
R
S
V
L
A
K
G
N
Y
A
K
S
L
G
L
A
G
L
F
S
W
E
I
D
A
D
N
G
-------------
D
I
L
N
A
M
H
E
G
M
A
G
G
V
V
T
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
79.11
29%
-47
- C1 -
1GOI
6
CHIB_SERMA
A:
[41-408]
-------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
Q
L
T
H
I
----
N
F
S
F
L
D
I
N
S
N
-
L
-----------
E
-
C
A
W
------------------------------------------------
D
P
A
T
N
D
A
--
K
A
R
--------------
D
--------------------------------------------
V
V
N
R
L
T
A
L
K
A
H
N
P
S
L
R
I
M
F
S
I
G
G
W
Y
Y
-
S
-------
N
D
L
G
V
S
H
A
N
Y
V
N
A
V
KT
P
A
S
R
A
K
F
A
Q
S
C
V
R
I
M
K
-
D
Y
----------------
G
-
F
-
D
G
V
N
I
D
W
E
Y
P
---------------------
Q
A
A
E
V
D
G
F
I
A
A
L
Q
E
I
R
T
L
L
N
Q
Q
T
I
T
--
D
--
G
---
R
--
Q
AL
P
Y
Q
L
T
I
A
G
A
G
G
A
F
F
L
S
-
R
-
Y
-
Y
S
K
L
A
Q
I
V
A
P
-
L
D
Y
I
N
L
M
T
Y
D
L
A
G
P
W
E
K
-
V
T
-
N
H
Q
A
A
L
F
G
D
A
A
G
-----
P
---------------
T
F
Y
NALREANLGWS
W
E
E
L
T
R
A
F
--
P
S
P
F
S
LT-----
V
D
A
A
V
Q
Q
H
L
M
-
M
E
-
G
V
P
S
A
K
I
V
M
G
V
P
F
Y
G
R
A
F
K
G
V
S
----
G
G
N
G
----
G
Q
Y
S
S
H
S
T
P
G
E
D
P
Y
P
S
T
D
Y
W
L
V
G
-
C
E
E
C
V
R
--
D
K
D
P
R
I
A
----
S
Y
R
Q
L
E
Q
M
L
Q
G
-----
N
Y
G
Y
Q
R
-----
L
W
N
D
K
T
K
T
P
Y
L
Y
H
A
Q
N
G
L
F
V
T
Y
D
D
A
E
S
F
K
Y
K
A
K
Y
I
K
Q
Q
Q
L
G
G
V
M
F
W
H
L
G
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.97
29%
-48
- C1 -
1UR8
8
?
A:
[41-408]
-------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
Q
L
T
H
I
----
N
F
S
F
L
D
I
N
S
N
-
L
-----------
E
-
C
A
W
------------------------------------------------
D
P
A
T
N
D
A
--
K
A
R
--------------
D
--------------------------------------------
V
V
N
R
L
T
A
L
K
A
H
N
P
S
L
R
I
M
F
S
I
G
G
W
Y
Y
-
S
-------
N
D
L
G
V
S
H
A
N
Y
V
N
A
V
KT
P
A
S
R
A
K
F
A
Q
S
C
V
R
I
M
K
-
D
Y
----------------
G
-
F
-
D
G
V
D
I
D
W
E
Y
P
---------------------
Q
A
A
E
V
D
G
F
I
A
A
L
Q
E
I
R
T
L
L
N
Q
Q
T
I
T
--
D
--
G
---
R
--
Q
AL
P
Y
Q
L
T
I
A
G
A
G
G
A
F
F
L
S
-
R
-
Y
-
Y
S
K
L
A
Q
I
V
A
P
-
L
D
Y
I
N
L
M
T
Y
D
L
A
G
P
W
E
K
-
V
T
-
N
H
Q
A
A
L
F
G
D
A
A
G
-----
P
---------------
T
F
Y
NALREANLGWS
W
E
E
L
T
R
A
F
--
P
S
P
F
S
LT-----
V
D
A
A
V
Q
Q
H
L
M
-
M
E
-
G
V
P
S
A
K
I
V
M
G
V
P
F
Y
G
R
A
F
K
G
V
S
----
G
G
N
G
----
G
Q
Y
S
S
H
S
T
P
G
E
D
P
Y
P
S
T
D
Y
W
L
V
G
-
C
E
E
C
V
R
--
D
K
D
P
R
I
A
----
S
Y
R
Q
L
E
Q
M
L
Q
G
-----
N
Y
G
Y
Q
R
-----
L
W
N
D
K
T
K
T
P
Y
L
Y
H
A
Q
N
G
L
F
V
T
Y
D
D
A
E
S
F
K
Y
K
A
K
Y
I
K
Q
Q
Q
L
G
G
V
M
F
W
H
L
G
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
78.67
29%
-48
- C1 -
1H0I
7
CHIB_SERMA
A:
[41-408]
-------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
Q
L
T
H
I
----
N
F
S
F
L
D
I
N
S
N
-
L
-----------
E
-
C
A
W
------------------------------------------------
D
P
A
T
N
D
A
--
K
A
R
--------------
D
--------------------------------------------
V
V
N
R
L
T
A
L
K
A
H
N
P
S
L
R
I
M
F
S
I
G
G
W
Y
Y
-
S
-------
N
D
L
G
V
S
H
A
N
Y
V
N
A
V
KT
P
A
S
R
T
K
F
A
Q
S
C
V
R
I
M
K
-
D
Y
----------------
G
-
F
-
D
G
V
D
I
D
W
E
Y
P
---------------------
Q
A
A
E
V
D
G
F
I
A
A
L
Q
E
I
R
T
L
L
N
Q
Q
T
I
T
--
D
--
G
---
R
--
Q
AL
P
Y
Q
L
T
I
A
G
A
G
G
A
F
F
L
S
-
R
-
Y
-
Y
S
K
L
A
Q
I
V
A
P
-
L
D
Y
I
N
L
M
T
Y
D
L
A
G
P
W
E
K
-
V
T
-
N
H
Q
A
A
L
F
G
D
A
A
G
-----
P
---------------
T
F
Y
NALREANLGWS
W
E
E
L
T
R
A
F
--
P
S
P
F
S
LT-----
V
D
A
A
V
Q
Q
H
L
M
-
M
E
-
G
V
P
S
A
K
I
V
M
G
V
P
F
Y
G
R
A
F
K
G
V
S
----
G
G
N
G
----
G
Q
Y
S
S
H
S
T
P
G
E
D
P
Y
P
S
T
D
Y
W
L
V
G
-
C
E
E
C
V
R
--
D
K
D
P
R
I
A
----
S
Y
R
Q
L
E
Q
M
L
Q
G
-----
N
Y
G
Y
Q
R
-----
L
W
N
D
K
T
K
T
P
Y
L
Y
H
A
Q
N
G
L
F
V
T
Y
D
D
A
E
S
F
K
Y
K
A
K
Y
I
K
Q
Q
Q
L
G
G
V
M
F
W
H
L
G
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
78.54
29%
-48
- C1 -
1E6R
-
?
A:
[41-408]
-------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
Q
L
T
H
I
----
N
F
S
F
L
D
I
N
S
N
-
L
-----------
E
-
C
A
W
------------------------------------------------
D
P
A
T
N
D
A
--
K
A
R
--------------
D
--------------------------------------------
V
V
N
R
L
T
A
L
K
A
H
N
P
S
L
R
I
M
F
S
I
G
G
W
Y
Y
-
S
-------
N
D
L
G
V
S
H
A
N
Y
V
N
A
V
KT
P
A
S
R
A
K
F
A
Q
S
C
V
R
I
M
K
-
D
Y
----------------
G
-
F
-
D
G
V
D
I
D
W
E
Y
P
---------------------
Q
A
A
E
V
D
G
F
I
A
A
L
Q
E
I
R
T
L
L
N
Q
Q
T
I
T
--
D
--
G
---
R
--
Q
AL
P
Y
Q
L
T
I
A
G
A
G
G
A
F
F
L
S
-
R
-
Y
-
Y
S
K
L
A
Q
I
V
A
P
-
L
D
Y
I
N
L
M
T
Y
D
L
A
G
P
W
E
K
-
V
T
-
N
H
Q
A
A
L
F
G
D
A
A
G
-----
P
---------------
T
F
Y
NALREANLGWS
W
E
E
L
T
R
A
F
--
P
S
P
F
S
LT-----
V
D
A
A
V
Q
Q
H
L
M
-
M
E
-
G
V
P
S
A
K
I
V
M
G
V
P
F
Y
G
R
A
F
K
G
V
S
----
G
G
N
G
----
G
Q
Y
S
S
H
S
T
P
G
E
D
P
Y
P
S
T
D
Y
W
L
V
G
-
C
E
E
C
V
R
--
D
K
D
P
R
I
A
----
S
Y
R
Q
L
E
Q
M
L
Q
G
-----
N
Y
G
Y
Q
R
-----
L
W
N
D
K
T
K
T
P
Y
L
Y
H
A
Q
N
G
L
F
V
T
Y
D
D
A
E
S
F
K
Y
K
A
K
Y
I
K
Q
Q
Q
L
G
G
V
M
F
W
H
L
G
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
78.30
29%
-49
- C1 -
1UR9
22
?
A:
[41-408]
-------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
Q
L
T
H
I
----
N
F
S
F
L
D
I
N
S
N
-
L
-----------
E
-
C
A
W
------------------------------------------------
D
P
A
T
N
D
A
--
K
A
R
--------------
D
--------------------------------------------
V
V
N
R
L
T
A
L
K
A
H
N
P
S
L
R
I
M
F
S
I
G
G
W
Y
Y
-
S
-------
N
D
L
G
V
S
H
A
N
Y
V
N
A
V
KT
P
A
S
R
A
K
F
A
Q
S
C
V
R
I
M
K
-
D
Y
----------------
G
-
F
-
D
G
V
D
I
N
W
E
Y
P
---------------------
Q
A
A
E
V
D
G
F
I
A
A
L
Q
E
I
R
T
L
L
N
Q
Q
T
I
T
--
D
--
G
---
R
--
Q
AL
P
Y
Q
L
T
I
A
G
A
G
G
A
F
F
L
S
-
R
-
Y
-
Y
S
K
L
A
Q
I
V
A
P
-
L
D
Y
I
N
L
M
T
Y
D
L
A
G
P
W
E
K
-
V
T
-
N
H
Q
A
A
L
F
G
D
A
A
G
-----
P
---------------
T
F
Y
NALREANLGWS
W
E
E
L
T
R
A
F
--
P
S
P
F
S
LT-----
V
D
A
A
V
Q
Q
H
L
M
-
M
E
-
G
V
P
S
A
K
I
V
M
G
V
P
F
Y
G
R
A
F
K
G
V
S
----
G
G
N
G
----
G
Q
Y
S
S
H
S
T
P
G
E
D
P
Y
P
S
T
D
Y
W
L
V
G
-
C
E
E
C
V
R
--
D
K
D
P
R
I
A
----
S
Y
R
Q
L
E
Q
M
L
Q
G
-----
N
Y
G
Y
Q
R
-----
L
W
N
D
K
T
K
T
P
Y
L
Y
H
A
Q
N
G
L
F
V
T
Y
D
D
A
E
S
F
K
Y
K
A
K
Y
I
K
Q
Q
Q
L
G
G
V
M
F
W
H
L
G
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
78.02
27%
-66
- C- -
1WB0
6
CHIT1_HUMAN
A:
[1-365]
-------------------------------------------------------------------------------------------------------
A
K
L
V
C
Y
F
T
N
W
A
Q
Y
R-------
Q
-
G
-
E
A
R
F
L
P
K
D
L
-
D
P
S
----
L
C
T
H
L
----
I
Y
A
F
A
G
M
T
N
H
-
Q
-----------
L
-
S
-
T
-----------------
T
-------------------
E
-------------------
W
-------------------------------------------------
N
D
E
--------
T
L
Y
Q
E
F
N
G
L
K
K
M
N
P
K
L
K
T
L
L
A
I
G
G
W
N
F
-
G
T------
Q
K
F
T
D
M
V
A
T
-------
A
N
N
R
Q
T
F
V
N
S
A
I
R
F
L
R
-
K
Y
----------------
S
-
F
-
D
G
L
D
L
D
W
E
Y
P
G
S
Q
G
----------------
S
P
A
V
D
K
E
R
F
T
T
L
V
Q
D
L
A
N
A
F
Q
Q
E
A
Q
T
--
S
--
G
K--
E
--
R
---
L
L
L
S
A
A
V
P
A
G
Q
T
Y
V
D
-
A
-
G
-
Y
E
-
V
D
K
I
A
Q
N
-
L
D
F
V
N
L
M
A
Y
D
F
H
G
S
W
E
K
-
V
T
-
G
H
N
S
P
L
Y
K
R
Q
E
E
-----
S
---------------
G
A
----------------------
A
A
S
L
N
-------
V
D
A
A
V
Q
-
Q
W
L
-
Q
K
-
G
T
P
A
S
K
L
I
L
G
M
P
T
Y
G
R
S
F
T
L
A
S
----
S
S
D
T
R
----
V
------------
G
A
P
A
T
G
-------
S
G
T
--
P
G
P
F
T
K
E
G
G
M
L
A
Y
Y
E
V
C
S
W
K
---------
G
A
T
K
-----
Q
R
I
Q
D
Q
K
V
P
Y
I
F
R
--
D
N
Q
W
V
G
F
D
D
V
E
S
F
K
T
K
V
S
Y
L
K
Q
K
G
L
G
G
A
M
V
W
A
L
D
L
D
D
F
A
G
FS
C
N--
Q
G
-
R
Y
P
L
I
Q
T
L
R
Q
E
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.93
29%
-47
- C1 -
1E15
-
?
A:
[41-408]
-------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
Q
L
T
H
I
----
N
F
S
F
L
D
I
N
S
N
-
L
-----------
E
-
C
A
W
------------------------------------------------
D
P
A
T
N
D
A
--
K
A
R
--------------
D
--------------------------------------------
V
V
N
R
L
T
A
L
K
A
H
N
P
S
L
R
I
M
F
S
I
G
G
W
Y
Y
-
S
-------
N
D
L
G
V
S
H
A
N
Y
V
N
A
V
KT
P
A
S
R
A
K
F
A
Q
S
C
V
R
I
M
K
-
D
Y
----------------
G
-
F
-
D
G
V
D
I
D
W
E
Y
P
---------------------
Q
A
A
E
V
D
G
F
I
A
A
L
Q
E
I
R
T
L
L
N
Q
Q
T
I
T
--
D
--
G
---
R
--
Q
AL
P
Y
Q
L
T
I
A
G
A
G
G
A
F
F
L
S
-
R
-
Y
-
Y
S
K
L
A
Q
I
V
A
P
-
L
D
Y
I
N
L
M
T
Y
D
L
A
G
P
W
E
K
-
V
T
-
N
H
Q
A
A
L
F
G
D
A
A
G
-----
P
---------------
T
F
Y
NALREANLGWS
W
E
E
L
T
R
A
F
--
P
S
P
F
S
LT-----
V
D
A
A
V
Q
Q
H
L
M
-
M
E
-
G
V
P
S
A
K
I
V
M
G
V
P
F
Y
G
R
A
F
K
G
V
S
----
G
G
N
G
----
G
Q
Y
S
S
H
S
T
P
G
E
D
P
Y
P
S
T
D
Y
W
L
V
G
-
C
E
E
C
V
R
--
D
K
D
P
R
I
A
----
S
Y
R
Q
L
E
Q
M
L
Q
G
-----
N
Y
G
Y
Q
R
-----
L
W
N
D
K
T
K
T
P
Y
L
Y
H
A
Q
N
G
L
F
V
T
Y
D
D
A
E
S
F
K
Y
K
A
K
Y
I
K
Q
Q
Q
L
G
G
V
M
F
W
H
L
G
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
77.77
29%
-45
- C1 -
1W1P
13
?
A:
[41-408]
-------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
Q
L
T
H
I
----
N
F
S
F
L
D
I
N
S
N
-
L
-----------
E
-
C
A
W
------------------------------------------------
D
P
A
T
N
D
A
--
K
A
R
--------------
D
--------------------------------------------
V
V
N
R
L
T
A
L
K
A
H
N
P
S
L
R
I
M
F
S
I
G
G
W
Y
Y
-
S
-------
N
D
L
G
V
S
H
A
N
Y
V
N
A
V
KT
P
A
S
R
A
K
F
A
Q
S
C
V
R
I
M
K
-
D
Y
----------------
G
-
F
-
D
G
V
D
I
D
W
E
Y
P
---------------------
Q
A
A
E
V
D
G
F
I
A
A
L
Q
E
I
R
T
L
L
N
Q
Q
T
I
T
--
D
--
G
---
R
--
Q
AL
P
Y
Q
L
T
I
A
G
A
G
G
A
F
F
L
S
-
R
-
Y
-
Y
S
K
L
A
Q
I
V
A
P
-
L
D
Y
I
N
L
M
T
Y
D
L
A
G
P
W
E
K
-
V
T
-
N
H
Q
A
A
L
F
G
D
A
A
G
-----
P
---------------
T
F
Y
NALREANLGWS
W
E
E
L
T
R
A
F
--
P
S
P
F
S
LT-----
V
D
A
A
V
Q
Q
H
L
M
-
M
E
-
G
V
P
S
A
K
I
V
M
G
V
P
F
Y
G
R
A
F
K
G
V
S
----
G
G
N
G
----
G
Q
Y
S
S
H
S
T
P
G
E
D
P
Y
P
S
T
D
Y
W
L
V
G
-
C
E
E
C
V
R
--
D
K
D
P
R
I
A
----
S
Y
R
Q
L
E
Q
M
L
Q
G
-----
N
Y
G
Y
Q
R
-----
L
W
N
D
K
T
K
T
P
Y
L
Y
H
A
Q
N
G
L
F
V
T
Y
D
D
A
E
S
F
K
Y
K
A
K
Y
I
K
Q
Q
Q
L
G
G
V
M
F
W
H
L
G
Q
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
75.43
30%
-45
- C1 -
1KFW
5
?
A:
[4-428]
----------------------------------------------------------------------------------------------
S
T
V
----
N
G
Y
R
N
V
G
Y
F
A
Q
W
G
V
Y
------------
G
R
A
F
Q
A
K
Q
L
-
D
V
S
GTAK
N
L
T
H
I
----
N
Y
S
F
G
N
I
N
N
Q
-
T
-----------
L
-
T
C
F
-----------------
M
-------------------
A
N
K
A
Q
G
T
G
PNG
S
D
G
A
G
D
A
--
W
A
D
--------------
F
G
-------
M
G
Y
A
ADKSVSGKAD
T
W
D
---
Q
---
P
L
A
--------
G
S
F
N
Q
L
K
Q
L
K
A
K
N
P
K
L
K
V
M
I
S
L
G
G
W
T
W
-
S
-------
K
N
F
S
K
A
A
A
T
-------
E
A
S
R
Q
K
L
V
S
S
C
I
D
L
Y
I
-
K
G
NLPNFEG
R
G
G
AGAAAG
I
-
F
-
D
G
I
D
I
D
W
E
W
P
G
T
N
S
G
L
A
G
N
---------
G
V
D
T
V
N
D
R
A
N
F
K
A
L
L
A
E
F
R
K
Q
L
D
A
Y
G
S
T
--
N
--
N
---
K
--
K
---
Y
V
L
S
A
F
L
P
A
N
P
A
D
I
D
A
G
-
G
-
W
D
-
D
P
A
N
F
K
S
-
L
D
F
G
S
I
Q
G
Y
D
L
H
G
A
W
N
P
T
L
T
-
G
H
Q
A
N
L
Y
D
D
P
A
D
-----
P
---------------
R
A
P---------------------
S
K
K
F
S
-------
A
D
K
A
V
K
-
K
Y
L
-
A
A
-
G
I
D
P
K
Q
L
G
L
G
L
A
A
Y
G
R
G
W
T
G
A
K
----
N
V
S
P
------
W
------------
G
P
A
T
D
--------
G
A
--
P
G
T
Y
--
E
T
A
N
E
D
Y
D
K
L
K
T
-----------
L
G
T
D
-----
H
Y
D
A
A
T
G
S
A
W
R
Y
D
--
G
T
Q
W
W
S
Y
D
N
I
A
T
T
K
Q
K
T
D
Y
I
V
S
K
G
L
G
G
G
M
W
W
E
L
S
G
D
R
N
G
------------
E
L
V
G
A
M
S
D
K
F
R
A
A
A
P
G
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------