@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0107: (2016-03-12 )
MARNKFDIDEELETAFSAAHLKRILVYVKPYQKSIYITLFVILLANVATMIGPYLTKIVIDDTIPNKNMTQLFWIAVIFIVSVIVTGLCMRYRIRSITLIGQDILKDMRTAIFGHLQKLPFSYFDSRPHGKILIRVVNYINMLSDLLSNGLINLISDILSVIVTLGFMLMIDPVLTLYSLALIPVLFVIVMVIKTAQRKAYQVLSNKQSNMNAYIHESIAGIKVTQSFSREEENFEIFTEVSNEYRRSWMKAVKIQFLLWPGVQNIAVMTTCLIYFVGIKGYGVDVSTGTLIAFIGYVGNFWNPVINIGNFYNSLITATTYLERIFETMDVEPDIKDIPNAKKMPPIVGNVDFKDVYFRYEEGVDILKGINFHVDAGESIALVGPTGAGKTTIINLLSRFYNINSGEILVDGENVEEVTLRSLRSQMGVMLQDTFIFSGTIIENIRYGKLDATEEEIIAAAKVVRAHDFISGLKDGYYTEVKERGSTLSAGQRQLISFARALLADPKILILDEATSSIDTQTEILLQEGLERLLEGRTSFIIAHRLSTIKNSSRIFYIDNGRIQEAGSHEELMAQHGYYYNLYQSQFDMLQAL
Atome Classification :
(56 SA)
.........10........20........30...-.....40........50........60......------.--.---70-------.-.......80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.....--..190.......200.......210.......220.......230......-.240....-...250-.......260..-.----....270...-...----.280-..------.-....290.......300.......---310.......320.......330-.....----...340---.-.......350.......360.-.--.--......370.......380.......390.......400..---.....410.......420.......430.......440......-.450---.---.-......460.......470.......480.......490.......500.......510.......520.......530..--.--....540.......550.......560.......570...--.-...580.......590.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MARNKFD
I
D
E
E
L
E
T
A
F
S
A
A
H
L
K
R
I
L
V
Y
V
KPYQK
S
-
I
Y
I
T
L
F
V
I
L
L
A
N
V
A
T
M
I
G
P
Y
L
T
K
I
V
IDDTIPNK------
N
--
M
---
T
Q
-------
L
-
F
W
I
A
V
I
F
I
V
S
V
I
V
T
G
L
C
M
R
Y
R
I
R
S
I
T
L
I
G
Q
D
I
L
K
D
M
R
T
A
I
F
G
H
L
Q
KL
P
F
S
Y
FDSRPH
G
K
I
L
I
R
V
V
N
Y
I
N
M
L
S
D
L
L
SN
G
L
I
N
L
I
S
D
I
L
S
V
I
V
T
L
G
F
M
L
M
I
D
P
V
L
T
L
Y
S
L
A
L
I
P
V
L
F
--
V
I
V
M
V
I
K
T
A
Q
R
K
A
Y
Q
V
L
SNKQSN
M
N
A
Y
I
H
ESIA
G
I
K
V
T
Q
SFSREEE
N
F
E
I
F
-
T
E
V
S
N
E
Y
R
-
R
S
W
M
K
A
-
V
K
I
Q
F
L
L
WPGV
Q
-
N
----
I
A
V
M
T
T
C
L
I
Y
-
F
V
G
----
I
K
G
Y
-
G
V
------D-VST
G
T
L
I
A
F
I
G
Y
V
G
N
F
W
N
P
V
I
N
I
G
---
N
F
Y
N
S
L
I
T
A
T
T
Y
L
E
R
I
F
E
TMDV--EP
D
I
K
----DIPNA----K-KMPPIVGNV
D
F
K
D
V
Y
F
R
Y--E-E--G--V
D
I
L
KGI
N
F
H
VDAGE
S
I
A
L
VGPTGA
G
K
T
T
I
I
N
L
L
S
R
F
YNIN---S
G
E
I
L
VDGE
N
V
E
E
V
T
L
R
S
L
R
S
QM
G
V
M
L
Q
D
T
F
I
FS
G
T
I
I
ENIRYG-KL-D---A---
T
-
E
E
E
I
I
A
A
A
K
V
V
R
A
H
D
F
I
S
G
LKDG
Y
Y
T
E
V
K
ERGSTL
S
A
G
Q
R
Q
L
I
S
F
A
R
A
L
LADP
K
I
L
I
L
DEATSSI
D
T
Q
T
E
I
L
L
Q
E
G
L
E
R
L
L--E--GR
T
S
F
I
I
A
H
R
L
S
TIKNS
S
R
I
F
Y
IDNGRIQEAG
S
H
E
E
L
M
A
Q--H-G
Y
Y
Y
N
L
Y
Q
S
Q
F
D
M
L
QAL
2
PsiBlast_PDB
92.00
36%
-125
- C2 -
4Q4A
1
Y288_THEMA
B:
[22-593]
-----------------
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
------
R
--
F
---
D
L
-------
L
-
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
--
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
-
D
R
V
N
E
S
L
R
-
K
V
G
T
K
A
-
Q
I
F
S
G
V
L
P
P
L
M
N
-
M
----
V
N
N
L
G
F
A
L
I
S
G
F
G
G
----
W
L
A
L
-
K
D
------
I
-
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
---
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
--
E
E
E
-
K
----
D
D
P
D
A
----
V
-
E
L
R
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
-
K
--
K
--
K
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
---
T
-
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
-
G
F
Y
Y
E
L
F
T
S
Q
Y
G
L
----
3
PsiBlast_PDB
91.22
36%
-124
- C2 -
4Q4H
-
Y288_THEMA
B:
[22-592]
-----------------
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
------
R
--
F
---
D
L
-------
L
-
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
--
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
-
D
R
V
N
E
S
L
R
-
K
V
G
T
K
A
-
Q
I
F
S
G
V
L
P
P
L
M
N
-
M
----
V
N
N
L
G
F
A
L
I
S
G
F
G
G
----
W
L
A
L
-
K
D
------
I
-
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
---
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
--
E
E
E
-
K
----
D
D
P
D
A
----
V
-
E
L
R
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
-
K
--
K
--
K
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
---
T
-
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
-
G
F
Y
Y
E
L
F
T
S
Q
Y
G
-----
1
PsiBlast_PDB
91.09
36%
-125
- C2 -
3QF4
1
Y288_THEMA
B:
[22-594]
-----------------
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
------
R
--
F
---
D
L
-------
L
-
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
--
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
-
D
R
V
N
E
S
L
R
-
K
V
G
T
K
A
-
Q
I
F
S
G
V
L
P
P
L
M
N
-
M
----
V
N
N
L
G
F
A
L
I
S
G
F
G
G
----
W
L
A
L
-
K
D
------
I
-
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
---
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
--
E
E
E
-
K
----
D
D
P
D
A
----
V
-
E
L
R
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
-
K
--
K
--
K
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
---
T
-
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
-
G
F
Y
Y
E
L
F
T
S
Q
Y
G
L
V
---
4
PsiBlast_PDB
90.92
36%
-125
- C2 -
4Q4J
-
Y288_THEMA
B:
[22-592]
-----------------
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
V
P
R
------
R
--
F
---
D
L
-------
L
-
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
--
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
-
D
R
V
N
E
S
L
R
-
K
V
G
T
K
A
-
Q
I
F
S
G
V
L
P
P
L
M
N
-
M
----
V
N
N
L
G
F
A
L
I
S
G
F
G
G
----
W
L
A
L
-
K
D
------
I
-
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
---
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
--
E
E
E
-
K
----
D
D
P
D
A
----
V
-
E
L
R
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
--
D
-
K
--
K
--
K
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
---
T
-
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
Q
K
--
R
-
G
F
Y
Y
E
L
F
T
S
Q
Y
G
-----
21
PsiBlast_CBE
88.68
35%
-118
- C2 -
2ONJ
4
Y1866_STAAM
B:
[2-576]
--------------------
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
------
A
--
L
---
T
T
DEKVHHL
T
-
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
--
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
-
D
K
K
N
T
N
F
L
-
T
R
A
L
K
H
-
T
R
-----
W
N
A
Y
S
-
F
----
A
A
I
N
T
V
T
D
I
G
-
P
I
I
----
V
I
G
V
-
G
A
YLAISG
S
-
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
---
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
--
D
Y
D
I
K
----
N
G
V
G
A
----
Q
-
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
--
N
-
D
--
N
E-
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
---
T
-
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
-------
22
PsiBlast_CBE
88.64
35%
-118
- C2 -
2HYD
3
Y1866_STAAM
B:
[2-576]
--------------------
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
------
A
--
L
---
T
T
DEKVHHL
T
-
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
--
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
-
D
K
K
N
T
N
F
L
-
T
R
A
L
K
H
-
T
R
-----
W
N
A
Y
S
-
F
----
A
A
I
N
T
V
T
D
I
G
-
P
I
I
----
V
I
G
V
-
G
A
YLAISG
S
-
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
---
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
--
D
Y
D
I
K
----
N
G
V
G
A
----
Q
-
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
--
N
-
D
--
N
E-
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
---
T
-
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
-------
6
PsiBlast_PDB
88.31
35%
-118
- C2 -
2ONJ
4
Y1866_STAAM
A:
[2-576]
--------------------
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
------
A
--
L
---
T
T
D
E
K
V
H
H
L
T
-
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
--
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
-
D
K
K
N
T
N
F
L
-
T
R
A
L
K
H
-
T
R
-----
W
N
A
Y
S
-
F
----
A
A
I
N
T
V
T
D
I
G
-
P
I
I
----
V
I
G
V
-
G
A
Y
L
A
I
S
G
S
-
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
---
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
--
D
Y
D
I
K
----
N
G
V
G
A
----
Q
-
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
--
N
-
D
--
N
E-
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
---
T
-
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
-------
5
PsiBlast_PDB
88.10
35%
-118
- C2 -
2HYD
3
Y1866_STAAM
A:
[2-576]
--------------------
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
N
N
H
------
A
--
L
---
T
T
D
E
K
V
H
H
L
T
-
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
--
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
-
D
K
K
N
T
N
F
L
-
T
R
A
L
K
H
-
T
R
-----
W
N
A
Y
S
-
F
----
A
A
I
N
T
V
T
D
I
G
-
P
I
I
----
V
I
G
V
-
G
A
Y
L
A
I
S
G
S
-
I
T
V
G
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
---
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
--
D
Y
D
I
K
----
N
G
V
G
A
----
Q
-
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
--
N
-
D
--
N
E-
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
---
T
-
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
--
Q
-
G
A
Y
E
H
L
Y
S
I
Q
-------
89
HHSearch
86.40
30%
-111
- C2 -
3B60
2
MSBA_SALTY
A:
[10-581]
-----------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
------
D
--
R
---
S
V
-------
L
-
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
--
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
-
D
K
V
S
N
K
M
R
-
L
Q
G
M
K
M
-
V
S
A
S
S
I
S
D
P
I
I
Q
-
L
----
I
A
S
L
A
L
A
F
V
L
-
Y
A
A
----
S
F
P
S
V
M
D
------
S
-
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
---
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
--
E
Q
E
K
D
----
E
G
K
------
R
-
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
--
P
-
G
--
R
E-
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
E
E
---
Y
---
S
-
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
-----
110
Fugue
85.59
29%
-111
- C2 -
3B60
2
MSBA_SALTY
A:
[10-581]
-----------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
------
D
--
R
---
S
V
-------
L
-
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
--
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
-
D
K
V
S
N
K
M
R
-
L
Q
G
M
K
M
-
V
S
A
S
S
I
S
D
P
I
I
Q
-
L
----
I
A
S
L
A
L
A
F
V
L
-
Y
A
A
----
S
F
P
S
-
V
M
------
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
---
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
--
E
Q
E
K
D
----
E
--
G
K
----
R
-
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
--
P
G
R
--
E
--
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
Y--
S
-
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
G
-----
10
PsiBlast_PDB
85.30
30%
-110
- C2 -
3B60
2
MSBA_SALTY
A:
[14-580]
---------------------
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
K
T
------
D
--
R
---
S
V
-------
L
-
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
--
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
-
D
K
V
S
N
K
M
R
-
L
Q
G
M
K
M
-
V
S
A
S
S
I
S
D
P
I
I
Q
-
L
----
I
A
S
L
A
L
A
F
V
L
-
Y
A
A
----
S
F
P
S
-
V
M
------
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
---
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
--
E
Q
E
-
K
----
D
-
E
G
K
----
R
-
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
--
P
G
R
--
E
--
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
Y--
S
-
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
--
H
-
G
V
Y
A
Q
L
H
K
M
Q
F
------
23
PsiBlast_CBE
82.01
31%
-109
- C2 -
4S0F
2
?
B:
[164-725]
--------------------------
F
L
K
P
L
K
K
T
-
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
------
K
--
L
---
N
D
-------
L
-
H
I
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
---
G
G
I
L
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
YG
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
------
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
-
S
F
K
E
G
M
L
Y
I
N
L
S
-
S
LTGI
V
A
G
L
G
G
I
V
I
L
-
W
A
G
AYNV
I
K
G
----------
N
-
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
---
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
AT
E
K
E
L
R
----
E
-
D
S
D
----
D
-
F
V
I
S
L
K
G
D
I
E
F
R
N
V
D
F
R
Y
--
G
-
L
--
R
--
K
P
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
-
N
E
-
N
---
V
---
D
-
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
--
D
--
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--
K
-
G
C
Y
F
K
M
W
K
Q
T
E
------
20
PsiBlast_PDB
81.10
29%
-116
- C2 -
4AYW
3
ABCBA_HUMAN
A:
[39-598]
---------------------
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
TVD
Y
S
D
N
--
L
---
T
R
-------
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
----
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
--
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
-
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
----
L
I
V
L
S
--
V
L
Y
-
K
G
G
----
L
L
M
G
-
S
A
------
H
-
M
T
V
G
E
L
S
S
F
L
M
Y
A
--
F
W
V
G
-
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
--
E
P
K
L
P
FN
E
G
V
I
L
N
E
----
K
-
S
F
Q
---
G
A
L
E
F
K
N
V
H
F
A
Y
PA
R
-
P
--
E
--
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
---
P
SSV
T
-
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-------------------------
92
HHSearch
80.99
28%
-120
- C2 -
3WMG
6
?
A:
[10-598]
----------------
T
G
V
T
A
R
R
I
F
A
L
A
W
S
S
S
A
T
M
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
K
S
K
------
S
Q
I
E
---
G
E
-------
T
-
W
K
Y
S
V
G
F
V
G
I
G
V
F
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
-
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
--
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
-
G
S
K
L
D
P
L
Y
-
R
L
G
R
R
R
-
Y
I
S
D
G
L
F
F
G
L
S
M
-
L
----
V
I
F
C
V
Y
A
L
A
L
-
W
W
G
----
G
Q
L
I
A
R
G
------
S
-
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
---
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
--
V
P
Q
Y
R
----
R
P
D
P
G
A
E
V
V
T
-
Q
P
L
V
L
K
Q
G
I
V
F
E
N
V
H
F
R
Y
--
P
-
T
--
R
MN
V
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
-
K
R
-
D
---
A
---
T
-
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
--
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
GP
S
-
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
----
18
PsiBlast_PDB
80.62
30%
-112
- C2 -
4AYX
7
ABCBA_HUMAN
A:
[8-574]
---------------------
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
TVDY
S
D
N
--
L
---
T
R
-------
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
----
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
--
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
-
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
----
L
I
V
L
S
--
V
L
Y
-
K
G
G
----
L
L
M
G
-
S
A
------
H
-
M
T
V
G
E
L
S
S
F
L
M
Y
A
--
F
W
V
G
-
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
--
E
P
K
L
P
F
N
E
G
V
I
L
N
E
----
K
-
S
F
Q
---
G
A
L
E
F
K
N
V
H
F
A
Y
PA
R
-
P
--
E
--
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
---
P
SSV
T
-
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P-
N
-
G
----------------
14
PsiBlast_PDB
80.62
31%
-104
- C2 -
4S0F
2
?
A:
[164-725]
--------------------------
F
L
K
P
L
K
K
T
-
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
------
K
--
L
---
N
D
-------
L
-
H
I
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
---
G
G
I
L
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
------
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
-
S
F
K
E
G
M
L
Y
I
N
L
S
-
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
-
W
A
G
A
Y
N
V
I
K
G
----------
N
-
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
---
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
A
T
E
K
E
L
R
----
E
-
D
S
D
----
D
-
F
V
I
S
L
K
G
D
I
E
F
R
N
V
D
F
R
Y
--
G
-
L
--
R
--
K
P
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
-
N
E
-
N
---
V
---
D
-
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
--
D
--
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--
K
-
G
C
Y
F
K
M
W
K
Q
T
E
------
19
PsiBlast_PDB
80.23
30%
-111
- C2 -
3ZDQ
6
ABCBA_HUMAN
A:
[8-572]
---------------------
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
TVDY
S
D
N
--
L
---
T
R
-------
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
----
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
--
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
-
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
----
L
I
V
L
S
--
V
L
Y
-
K
G
G
----
L
L
M
G
-
S
A
------
H
-
M
T
V
G
E
L
S
S
F
L
M
Y
A
--
F
W
V
G
-
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
--
E
P
K
L
P
F
N
E
G
V
I
L
N
E
----
K
-
S
F
Q
---
G
A
L
E
F
K
N
V
H
F
A
Y
PA
R
-
P
--
E
--
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
---
P
SSV
T
-
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P--------------------
17
PsiBlast_PDB
80.04
30%
-110
- C2 -
4AYT
8
ABCBA_HUMAN
A:
[8-567]
---------------------
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
TVDY
S
D
N
--
L
---
T
R
-------
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
----
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
--
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
-
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
----
L
I
V
L
S
--
V
L
Y
-
K
G
G
----
L
L
M
G
-
S
A
------
H
-
M
T
V
G
E
L
S
S
F
L
M
Y
A
--
F
W
V
G
-
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
--
E
P
K
L
P
F
N
E
G
V
I
L
N
E
----
K
-
S
F
Q
---
G
A
L
E
F
K
N
V
H
F
A
Y
PA
R
-
P
--
E
--
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
---
P
SSV
T
-
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-------------------------
91
HHSearch
79.54
28%
-108
- C2 -
3ZDQ
6
ABCBA_HUMAN
A:
[6-572]
-------------------
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
------
T
--
V
DY
S
D
N
-------
L
-
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
--
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
-
A
S
K
V
D
H
V
M
-
Q
L
A
R
K
E
-
A
F
A
R
A
G
F
F
G
A
T
G
-
L
----
S
G
N
L
I
V
L
S
V
L
-
Y
K
G
----
G
L
L
M
G
S
A
------
H
-
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
---
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
--
E
P
K
L
P
----
F
N
E
G
V
----
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
--
P
-
A
RP
E
--
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
PSS
V
---
T
-
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P--------------------
12
PsiBlast_PDB
79.49
31%
-119
- C2 -
4RY2
-
?
A:
[164-727]
--------------------------
F
L
K
P
L
K
K
T
-
V
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
K
F
E
------
K
--
L
---
N
D
-------
L
-
H
I
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
---
G
G
I
L
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
------
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
-
S
F
K
E
G
M
L
Y
I
N
L
S
-
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
-
W
A
G
A
Y
N
V
I
K
G
----------
N
-
M
S
G
G
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
---
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
AT
E
K
E
L
----------------------
G
D
I
E
F
R
N
V
D
F
R
Y
--
G
-
L
--
R
--
K
P
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
-
N
E
-
N
---
V
---
D
-
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
--
D
--
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
--
K
-
G
C
Y
F
K
M
W
K
Q
T
E
N
T
----
55
PsiBlast_CBE
68.02
43%
-104
- C2 -
1XEF
3
HLYBP_ECOLX
B:
[1-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----
63
PsiBlast_CBE
67.75
39%
-97
- C2 -
2IXE
4
TAP1_RAT
A:
[15-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
K
F
Q
D
V
S
F
A
Y
PN
H
-
P
--
N
--
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
R
-
T
---
P
---
T
-
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
W
A
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
-----------
35
PsiBlast_CBE
67.72
43%
-103
- C2 -
2FF7
1
A:
[7-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----
99
HHSearch
67.71
44%
-102
- C2 -
2FF7
1
A:
[6-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
I
T
F
R
N
I
R
F
R
Y
--
K
-
P
D-
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
------
54
PsiBlast_CBE
67.71
43%
-105
- C2 -
1XEF
3
HLYBP_ECOLX
C:
[1-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----
48
PsiBlast_CBE
67.68
43%
-107
- C2 -
2FGJ
2
D:
[7-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----
27
PsiBlast_CBE
67.58
43%
-87
- C2 -
3NH9
3
A:
[25-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
M
F
D
L
L
K
E
--
E
T
E
V
K
----
D
L
P
G
A
----
G
-
P
L
R
F
Q
K
G
R
I
E
F
E
N
V
H
F
S
Y
--
A
-
D
--
G
--
R
E
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
V
-
T
---
A
---
G
-
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
-
G
V
Y
A
D
M
W
Q
L
Q
-------
26
PsiBlast_CBE
67.52
43%
-92
- C2 -
3NHA
4
A:
[25-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
M
F
D
L
L
K
E
--
E
T
E
V
K
----
D
L
P
G
A
----
G
-
P
L
R
F
Q
K
G
R
I
E
F
E
N
V
H
F
S
Y
--
A
-
D
-----
R
E
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
V
-
T
---
A
---
G
-
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
-
G
V
Y
A
D
M
W
Q
L
Q
-------
44
PsiBlast_CBE
67.43
43%
-105
- C2 -
2FGK
2
HLYBP_ECOLX
C:
[7-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----
52
PsiBlast_CBE
67.21
43%
-103
- C2 -
2FFA
2
A:
[7-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----
51
PsiBlast_CBE
67.11
43%
-99
- C2 -
2FGJ
2
HLYBP_ECOLX
A:
[7-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----
25
PsiBlast_CBE
67.08
43%
-90
- C2 -
3NHB
3
A:
[25-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
M
F
D
L
L
K
E
--
E
T
E
V
K
----
D
L
P
G
A
----
G
-
P
L
R
F
Q
K
G
R
I
E
F
E
N
V
H
F
S
Y
--
A
-
D
-----
R
E
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
V
-
T
---
A
---
G
-
N
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
--
A
--
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
--
G
-
G
V
Y
A
D
M
W
Q
L
Q
-------
46
PsiBlast_CBE
67.01
43%
-103
- C2 -
2FGK
2
HLYBP_ECOLX
A:
[7-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----
53
PsiBlast_CBE
66.88
43%
-101
- C2 -
1XEF
3
D:
[1-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----
61
PsiBlast_CBE
66.81
39%
-97
- C2 -
2IXF
5
TAP1_RAT
A:
[15-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
K
F
Q
D
V
S
F
A
Y
PN
H
-
P
--
N
--
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
R
-
T
---
P
---
T
-
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
-----------
56
PsiBlast_CBE
66.81
43%
-105
- C2 -
1XEF
3
HLYBP_ECOLX
A:
[1-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----
59
PsiBlast_CBE
66.79
39%
-97
- C2 -
2IXF
4
TAP1_RAT
C:
[15-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
K
F
Q
D
V
S
F
A
Y
PN
H
-
P
--
N
--
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
R
-
T
---
P
---
T
-
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
W
A
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
-----------
98
HHSearch
66.63
38%
-96
- C2 -
2IXE
4
TAP1_RAT
A:
[13-256]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
G
L
V
K
F
Q
D
V
S
F
A
Y
--
P
-
N
--
H
PN
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
-
L
T
-
R
---
T
P
--
T
-
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
--
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
V
E
A
--------
60
PsiBlast_CBE
66.48
39%
-97
- C2 -
2IXF
4
TAP1_RAT
B:
[15-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
K
F
Q
D
V
S
F
A
Y
PN
H
-
P
--
N
--
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
R
-
T
---
P
---
T
-
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
-----------
49
PsiBlast_CBE
66.21
43%
-101
- C2 -
2FGJ
2
HLYBP_ECOLX
C:
[7-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----
37
PsiBlast_CBE
66.14
43%
-105
- C2 -
2PMK
1
A:
[3-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----
66
PsiBlast_CBE
65.95
38%
-93
- C2 -
2IXG
2
A:
[15-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
K
F
Q
D
V
S
F
A
Y
PN
H
-
P
--
N
--
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
R
-
T
---
P
---
T
-
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
A
V
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
-----------
58
PsiBlast_CBE
65.77
39%
-99
- C2 -
2IXF
4
D:
[15-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
K
F
Q
D
V
S
F
A
Y
PN
H
-
P
--
N
--
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
R
-
T
---
P
---
T
-
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
-----------
67
PsiBlast_CBE
65.57
38%
-96
- C2 -
4K8O
4
A:
[15-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
K
F
Q
D
V
S
F
A
Y
PN
H
-
P
--
N
--
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
R
-
T
---
P
---
T
-
M
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
A
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
--
E
WA
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
--
G
-
G
C
Y
R
S
M
-----------
45
PsiBlast_CBE
65.47
43%
-104
- C2 -
2FGK
2
HLYBP_ECOLX
B:
[7-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----
43
PsiBlast_CBE
65.16
43%
-105
- C2 -
2FGK
2
D:
[7-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----
50
PsiBlast_CBE
64.75
43%
-102
- C2 -
2FGJ
2
HLYBP_ECOLX
B:
[7-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----
42
PsiBlast_CBE
64.69
43%
-102
- C2 -
3B5J
1
A:
[3-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
-
N
P
-
G
---
M
---
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P-
E
-
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----
97
HHSearch
64.62
41%
-101
- C2 -
1MV5
3
LMRA_LACLA
A:
[2-242]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
--
D
-
D
--
S
--
E
Q
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
-
L
E
-
G
D--
Y
---
T
-
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
-
P
L
Y
A
K
Y
V
S
E
Q
L
T
V
G
---
95
HHSearch
63.51
33%
-99
* C2 *
3VX4
3
?
A:
[29-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
L
D
G
D
I
S
F
E
N
L
S
Y
K
Y
--
G
-
F
--
G
--
R
D
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
G
-
A
K
-
E
G--
T
---
S
-
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
---
T
--
E
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
-
G
F
Y
Y
N
L
F
N
---------
40
PsiBlast_CBE
63.37
42%
-92
- C2 -
1MV5
2
LMRA_LACLA
B:
[5-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
V
D
F
A
Y
--
D
-
D
--
S
--
E
Q
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
G
-
D
---
Y
---
T
-
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
-
P
L
Y
A
K
Y
V
S
E
Q
L
T
V
G
---
41
PsiBlast_CBE
63.03
42%
-95
- C2 -
1MV5
3
LMRA_LACLA
A:
[5-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
V
D
F
A
Y
--
D
-
D
--
S
--
E
Q
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
G
-
D
---
Y
---
T
-
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
-
P
L
Y
A
K
Y
V
S
E
Q
L
T
V
G
---
39
PsiBlast_CBE
62.79
42%
-99
- C2 -
1MV5
3
LMRA_LACLA
C:
[5-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
V
D
F
A
Y
--
D
-
D
--
S
--
E
Q
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
G
-
D
---
Y
---
T
-
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
-
P
L
Y
A
K
Y
V
S
E
Q
L
T
V
G
---
65
PsiBlast_CBE
62.76
34%
-98
- C2 -
3VX4
3
?
A:
[29-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
L
D
G
D
I
S
F
E
N
L
S
Y
K
Y
--
G
-
F
--
G
--
R
D
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
G
-
A
K
-
E
---
G
---
T
S
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
T
--
E
---
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
-
G
F
Y
Y
N
L
F
----------
64
PsiBlast_CBE
62.69
34%
-97
- C2 -
3VX4
3
?
D:
[28-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
F
L
D
G
D
I
S
F
E
N
L
S
Y
K
Y
--
G
-
F
--
G
--
R
D
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
K
V
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
S
I
M
D
N
L
V
L
G
-
A
K
-
E
---
G
---
T
S
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
S
D
I
E
Q
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
N
L
L
Q
M
T
--
E
---
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
A
K
--
Q
-
G
F
Y
Y
N
L
F
----------
38
PsiBlast_CBE
59.14
42%
-98
- C2 -
1MV5
3
D:
[5-241]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
V
D
F
A
Y
--
D
-
D
--
S
--
E
Q
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
G
-
D
---
Y
---
T
-
D
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
--
H
-
P
L
Y
A
K
Y
V
S
E
Q
L
T
V
----