@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0288: (2016-03-14 )
MHKMRFFQSVQFKLVIMYLLLIIVAMQVIGAYFVRELEGQLEKNFQDSITNSITLLDYNAREEIIKNSDNSVKLQNDIRELLVDYSRASSNLIEVRIVDDKGKILGTSNLNNQGIVGQKSNDPLVKRTLSLGTTSEDKIYKDESNKNNRVWVNVSSIKNKGQVIGAIYLVADIESVYKQVDDITNIFITGTLIAMIITAVLGILLSRTITKPIVEMKRQAYAMARGNYSRKVKVYGVDEIGELADSFNTLTKRVQEAQAMTEGERRKLSSVLAYMTDGVIATDRRGKVILINTPAEKMLRVKHESANGRSIIDVLDIGDTYQFEDLMEVDGSLTMDRSTLDKPYVLRANFSVIQRETGFNNGVIAVLHDITDQEKVDQERRDFVSNVSHELRTPLTSMHSYLEALSDGAWEDKEIAPRFLEVTQNETERMIRLVNDLLKLSRMDGGREQLEKSFVNFTDFFNHIIDRFEMMKKETIMFKRHIPREPVIIEIDEDKVMQVLDNIISNANKYSPDGGRISFYLKKFEDEIEVSIADEGLGVPDEDLANVFDRFFRVDKARSREMGGTGLGLAIAREVIEAHGGRIWAERNKNKGTIIKFTLPYSDLPEDDWE
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.-.-.....330.....-..340.-......350...-...-.360.......370....------...---------380--------........390.......400...--....410........420.......430.......440.......450.......460---.....--..---470-...-.-.------....---480..-.....490.......500.......510---...---.....520.--....----..530.......540.......550.......560.......570.....-..580.......590.......600.......610
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MH
K
M
R
F
F
Q
S
V
Q
F
K
L
V
I
M
Y
L
L
L
I
I
V
A
M
Q
V
I
G
A
Y
F
V
R
E
L
E
G
Q
L
E
K
N
F
Q
D
SIT
N
S
I
T
L
LD
Y
N
A
R
E
E
I
I
KNSDN
S
V
K
L
Q
N
D
I
R
E
L
L
V
D
Y
SRASS
N
L
I
E
V
R
I
VDDKG
K
I
L
GTSNLNNQGIVGQKSN
D
P
L
V
K
R
TLSLGTTSED
K
I
YKDESNKN
N
R
V
W
V
N
V
S
SIKNKG
Q
V
I
G
A
I
Y
L
V
A
D
I
E
S
V
Y
K
Q
V
D
D
I
T
N
I
F
I
T
G
T
L
I
A
M
I
I
T
A
V
L
G
I
L
L
S
R
T
I
T
K
P
I
V
E
M
K
R
Q
A
Y
A
MARGNY
S
R
K
V
K
V
Y
G
V
D
E
I
G
E
L
A
D
S
F
N
T
L
T
K
R
V
Q
E
A
Q
AM
T
E
G
E
R
R
K
L
S
S
V
L
A
Y
M
TD
G
V
I
ATDRRG
K
V
I
L
I
NT
P
A
E
K
M
L
R
V
KHESANG
R
S
I
I
D
V
L
DIGDTY
Q
F
-
E
-
D
L
M
EVDG
S
L
TMDR-STLDK
P
-
Y
V
L
RAN
F
S
V
I
Q
R-ETG-FNN
G
V
I
A
V
LHDIT
D
Q
E
K
V
------
D
Q
E
---------
R
R
---------
D
F
V
S
N
V
S
H
E
L
RT
P
L
T
S
M
H
S
Y
L
E
A
L--SDGAWE-DK
E
I
A
P
R
F
L
E
VTQ
N
E
T
E
R
M
I
R
L
V
N
D
L
L
K
L
S
RMDG
G
R
E
Q
L
E
K
S
F
V
N
F
T
D
F
F
N
---
H
I
I
D
R
--
F
E
---
M
---
M
K
K
-
E
-
T
------
I
M
F
K
---RHIPR-E
P
V
I
I
E
ID
E
D
K
V
M
Q
V
L
D
N
I
I
S
NANKYS----PDG---
G
R
I
S
F
Y
L
K
K--FED
E
----
I
E
V
S
IADEGLGV
P
D
E
D
L
A
N
V
F
D
R
F
F
R
V
D
K
ARSREMGGT
G
L
G
L
A
I
A
R
E
V
I
E
-AHG
G
R
I
W
A
ERNKNKG
T
I
I
K
F
TLPYSDLPEDDWE
1
PsiBlast_PDB
87.50
45%
-58
- C4 -
4I5S
-
?
A:
[43-432]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
E
C
N
I
L
D
I
L
D
-
D
D
S
Y
T
Y
-
N
-
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
Y
D
E
F
-
I
T
L
R
I
R
F
A
L
N
R
R
-
E
S
G
-
F
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
------
E
R
E
---------
R
R
---------
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
--
D
D
G
A
L
T
-
E
S
-
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-----
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
---
Y
I
L
D
R
--
F
D
---
Q
---
I
Q
S
-
Q
-
Q
------
S
T
--E
I
I
R
D
Y
P
D
-
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
----
P
D
G
---
G
K
V
T
I
T
M
Q
T
--
T
D
T
Q
----
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
----------
87
Fugue
86.61
44%
-59
- C4 -
4I5S
-
?
A:
[37-432]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
E
C
N
I
L
D
I
L
D
-
D
D
S
Y
T
Y
-
N
-
D
L
I
T
K
T
P
E
I
V
L
T
R
-
R
D
E
Y
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
-
E
S
G
-
F
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
------
E
R
E
---------
R
R
---------
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
--
D
D
G
A
L
T
-
E
-
S
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
S
H
-----
L
D
V
E
L
T
N
F
T
A
F
M
N
---
Y
I
L
D
R
--
F
D
---
Q
---
I
Q
S
-
Q
Q
S
------
T
E
I
I
---
R
D
Y
P
D
-
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
----
P
D
G
---
G
K
V
T
I
T
M
Q
T
--
T
D
T
Q
----
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
----------
3
PsiBlast_PDB
86.34
53%
-81
- C3 -
4U7O
1
?
A:
[25-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
------
D
N
D
---------
R
K
---------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
--
S
D
G
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
---
Y
V
L
D
R
--
F
D
---
M
---
I
L
K
-
K
-
D
DNPA
K
Y
Y
T
I
K
---
R
E
F
T
K
-
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
----
P
D
G
---
G
V
V
T
C
R
L
L
E
--
T
H
N
Q
----
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
--------
2
PsiBlast_PDB
79.79
53%
-87
- C3 -
4U7N
-
?
A:
[39-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
--
S
D
G
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
---
Y
V
L
D
R
--
F
D
---
M
---
I
L
K
-
K
-
D
DNY---
Y
T
I
K
---
R
E
F
T
K
-
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
----
P
D
G
---
G
V
V
T
C
R
L
L
E
--
T
H
N
Q
----
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
-----------
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
--------
21
PsiBlast_CBE
78.88
53%
-73
- C3 -
4U7O
1
?
B:
[37-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
--
S
D
G
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
------
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
---
Y
V
L
D
R
--
F
D
---
M
---
I
L
K
-
K
-
D
DNPAKY
Y
T
I
K
---
R
E
F
T
K
-
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
----
P
D
G
---
G
V
V
T
C
R
L
L
E
--
T
H
N
Q
----
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
R
---
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
--------
18
PsiBlast_PDB
73.17
25%
-78
- C3 -
3A0R
1
?
A:
[12-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
L
E
S
L
E
T
A
I
I
T
L
S
K
D
G
R
I
T
E
W
N
K
K
A
E
Q
L
F
G
L
K
K
E
N
V
L
G
R
R
L
K
D
L
P
D
F
E
E
I
G
S
V
A
E
-
S
V
F
E
N
K
E
P
V
F
L
N
F
-
Y
K
F
G
E
R
-
Y
-
F
N
I
R
F
S
P
F
R
N
A
K
T
Q
-
L
L
E
G
V
I
I
T
I
D
D
V
T
E
L
Y
K
Y
------
E
E
E
---------
R
K
R
R
E
R
L
S
I
L
G
E
M
T
A
R
V
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
M
R
M
--
K
K
H
L
-
D
-
D
P
E
T
L
K
K
Y
I
N
I
I
T
N
E
L
S
R
L
E
T
I
V
K
E
I
L
E
Y
S
K
---
E
R
-
V
L
E
F
T
E
F
N
L
N
E
L
I
R
---
E
V
Y
V
L
--
F
E
E
--
K
---
I
R
K
-
M
-
N
------
I
D
F
C
---
F
E
T
D
N
-
E
D
L
R
V
E
A
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
----
G
E
N
---
G
K
I
K
I
T
S
E
D
--
M
Y
T
K
----
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
------
T
T
------
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
W
T
E
-
N
R
E
N
G
V
V
F
I
F
E
I
P
----------
4
PsiBlast_PDB
68.26
54%
-87
- C3 -
3SL2
2
A:
[2-153]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
I
Q
I
V
R
F
M
S
---
L
I
I
D
R
--
F
E
---
M
---
T
K
E
-
Q
---------
E
F
I
---
R
N
L
P
D
-
R
D
L
Y
V
E
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
----
P
E
G
---
G
H
V
T
F
S
I
D
V
--
N
E
E
E
E
L
--
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
Y
K
E
-------
73
HHSearch
67.88
54%
-82
- C3 -
3SL2
2
A:
[3-153]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
I
V
R
F
M
S
---
L
I
I
D
R
--
F
E
---
M
---
T
K
E
-
Q
---------
E
F
I
---
R
N
L
P
D
-
R
D
L
Y
V
E
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
----
P
E
G
---
G
H
V
T
F
S
I
D
V
NE
E
E
E
L
----
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
Y
K
E
-------
65
HHSearch
67.77
25%
-72
- C3 -
3A0R
1
?
A:
[9-348]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
E
S
I
L
E
S
L
E
T
A
I
I
T
L
S
K
D
G
R
I
T
E
W
N
K
K
A
E
Q
L
F
G
L
K
K
E
N
V
L
G
R
R
L
K
D
L
P
D
F
E
E
I
G
S
V
-
A
E
S
V
F
E
N
K
E
P
V
F
L
N
F
--
Y
K
F
G
E
-
R
Y
F
N
I
R
F
S
P
F
R
N
-
A
K
T
Q
L
L
E
G
V
I
I
T
I
D
D
V
T
E
L
Y
K
Y
------
E
E
E
R
K
R
R
E
R
L
S
I
L
G
---------
E
M
T
A
R
V
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
M
R
M
--
K
K
H
L
D
D
--
P
E
T
L
K
K
Y
I
N
I
I
T
N
E
L
S
R
L
E
T
I
V
K
E
I
L
E
Y
S
K
E
R
----
V
L
E
F
T
E
F
N
L
N
E
L
I
R
---
E
V
Y
V
L
--
F
E
---
E
---
K
I
R
K
M
-
N
------
I
D
F
C
---
F
E
T
D
N
-
E
D
L
R
V
E
A
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
----
G
E
N
---
G
K
I
K
I
T
S
E
D
--
M
Y
T
K
----
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
T
T
------------
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
W
T
E
N
R
-
E
N
G
V
V
F
I
F
E
I
P
K
T
P
E
K
-----
13
PsiBlast_PDB
65.49
33%
-51
- C3 -
4BIX
3
CPXA_ECOLI
A:
[66-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
Q
V
V
T
A
L
E
R
M
M
T
S
Q
Q
R
L
-------------------------------
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
--
R
R
R
S
G
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
-
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
---
E
V
L
D
N
A
A
F
E
A
E
Q
M
---
G
K
S
-
L
-
T
------
V
N
F
-------
P
P
-
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
----
H
T
K
---
I
E
V
G
F
A
V
D
K
----
D
G
----
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
--------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
----------
10
PsiBlast_PDB
65.34
29%
-58
- C3 -
4Q20
-
DIVL_CAUCR
A:
[40-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
---------
D
F
V
G
N
V
S
Y
E
L
R
T
P
L
T
T
I
I
G
Y
S
E
L
L
E
R
A
D
--
S
E
-
R
G
R
---
N
H
V
A
A
V
R
A
A
A
T
Q
L
A
R
S
I
D
D
V
L
D
M
A
Q
I
D
A
G
E
M
A
L
E
I
E
D
I
R
V
S
D
L
L
L
---
N
A
Q
E
R
A
-
L
K
---
D
---
A
Q
L
-
G
-
G
------
V
T
L
A
---
V
E
C
E
E
-
D
V
G
L
I
R
G
D
G
K
R
L
A
Q
T
L
D
H
L
V
E
N
A
L
R
Q
T
----
P
P
G
---
G
R
V
T
L
S
A
R
R
--
A
L
G
E
----
V
R
L
D
V
S
D
T
G
R
G
V
P
F
H
V
Q
A
H
I
F
D
R
F
V
------
G
R
D
R
G
G
P
G
L
G
L
A
L
V
K
A
L
V
E
-
L
H
G
G
W
V
A
L
E
S
E
P
G
N
G
S
T
F
T
C
H
L
P
E
T
Q
-------
8
PsiBlast_PDB
64.73
33%
-46
- C3 -
4JAS
2
?
A:
[14-249]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
------
D
R
M
---------
K
T
---------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
--
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
--
F
A
---
S
---
S
H
N
-
V
-
N
------
V
L
F
E
---
S
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
K
--------
Y
V
K
V
--
I
L
D
E
K
DG
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
-------
6
PsiBlast_PDB
64.70
34%
-44
- C3 -
4JAV
6
?
A:
[14-248]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
------
D
R
M
---------
K
T
---------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
--
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
--
F
A
---
S
---
S
H
N
-
V
-
N
------
V
L
F
E
---
S
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
K
--------
Y
V
K
V
--
I
L
D
E
K
DG
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
--------
22
PsiBlast_CBE
64.18
34%
-47
- C3 -
4JAV
6
?
B:
[14-248]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
------
D
R
M
---------
K
T
---------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
--
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
--
F
A
---
S
---
S
H
N
-
V
-
N
------
V
L
F
E
---
S
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
K
--------
Y
V
K
V
--
I
L
D
E
K
DG
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
--------
12
PsiBlast_PDB
63.94
33%
-41
- C3 -
4BIW
5
CPXA_ECOLI
A:
[66-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
Q
V
V
T
A
L
E
R
M
M
T
S
Q
Q
R
L
-------------------------------
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
--
R
R
R
S
G
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
-
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
---
E
V
L
D
N
A
A
F
E
A
E
Q
M
---
G
K
S
-
L
-
T
------
V
N
F
-------
P
P
-
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
----
H
T
K
---
I
E
V
G
F
A
V
D
K
----
D
G
----
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
----------
5
PsiBlast_PDB
63.73
34%
-41
- C3 -
3DGE
3
?
A:
[14-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
------
D
R
M
---------
K
T
---------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
--
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
--
F
A
---
S
---
S
H
N
-
V
-
N
------
V
L
F
E
---
S
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
K
--------
Y
V
K
V
--
I
L
D
E
K
DG
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
A
------
23
PsiBlast_CBE
63.70
34%
-45
- C3 -
3DGE
2
?
B:
[14-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
------
D
R
M
---------
K
T
---------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
--
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
SAV
N
A
I
K
E
--
F
A
---
S
---
S
H
N
-
V
-
N
------
V
L
F
E
---
S
N
V
P
C
--
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
KKDA
P
D
K
--------
Y
V
K
V
--
I
L
D
E
KDGG
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
A
------
67
HHSearch
63.44
32%
-63
- C- -
2C2A
2
?
A:
[2-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
T
E
S
K
E
L
E
R
L
K
R
I
D
R
M
---------
K
T
---------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
--
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
---
S
A
V
N
A
--
I
K
---
E
---
F
A
S
S
H
-
N
------
V
N
V
L
---
F
E
S
N
V
P
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
----
K
K
D
AP
D
K
Y
V
K
V
I
L
D
E
--
K
D
G
G
----
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
A
------
17
PsiBlast_PDB
63.10
32%
-45
- C3 -
4CB0
6
CPXA_ECOLI
A:
[66-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
Q
M
V
T
A
L
E
R
M
M
T
S
Q
Q
R
L
-------------------------------
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
--
R
R
R
S
G
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
-
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
---
E
V
L
D
N
A
A
F
E
---
A
E
Q
M
G
K
S
-
L
-
T
------
V
N
F
-------
P
P
-
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
----
H
T
K
---
I
E
V
G
F
A
V
D
K
----
D
G
----
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
----------
15
PsiBlast_PDB
62.98
32%
-45
- C3 -
4BIZ
3
CPXA_ECOLI
A:
[66-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
Q
M
V
T
A
L
E
R
M
M
T
S
Q
Q
R
L
-------------------------------
L
S
D
I
S
E
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
--
R
R
R
S
G
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
-
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
---
E
V
L
D
N
A
A
F
E
A
E
Q
M
---
G
K
S
-
L
-
T
------
V
N
F
-------
P
P
-
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
----
H
T
K
---
I
E
V
G
F
A
V
D
K
----
D
G
----
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
--
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
----------
31
PsiBlast_CBE
62.16
33%
-46
- C3 -
4BIW
2
CPXA_ECOLI
B:
[66-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
Q
V
V
T
A
L
E
R
M
M
T
S
Q
Q
R
L
-------------------------------
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
--
R
R
R
S
G
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
-
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
---
E
V
L
D
N
A
A
F
E
A
E
Q
M
---
G
K
S
-
L
-
T
------
V
N
F
-------
P
P
-
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
----
H
T
K
---
I
E
V
G
F
A
V
D
K
----
D
G
----
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
----------
16
PsiBlast_PDB
61.54
32%
-42
- C3 -
4BIV
2
CPXA_ECOLI
A:
[66-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
Q
M
V
T
A
L
E
R
M
M
T
S
Q
Q
R
L
-------------------------------
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
--
R
R
R
S
G
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
-
N
Q
Q
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
---
E
V
L
D
N
A
A
F
E
---
A
E
Q
M
G
K
S
-
L
-
T
------
V
N
F
-------
P
P
-
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
----
H
T
K
---
I
E
V
G
F
A
V
D
K
----
D
G
----
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
----------