@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0919: (2016-03-19 )
MSTIEINQLKIEVADRVLVEIPHLLVSKKARIGIIGQNGLGKTTLMEVIAGAKEATSGTVTTQGKLAYIKQLSTDTSTKSGGEKTRKATQHAMRQNPSVLLADEPTSNLDVESVKHLERQWSDFHGALIIISHDRAFLDALCTEIWEIKNQKIHVYKGNYHAYLEQKQQQENQAELAYKEFKNKKKQLQASQTHHEIEAGRIVKPGKRLNNKEASAFKAGKGTQQKKQHSTIKALEKRIERLGNVEKPHTTKPIKIITPDNRVIKKGNTILSAKETAYEIAGRKLFETKAFSIKAGDKVALIGENASGKTTFLKEIIQENPNLLCNPQAKIAYFDQELNGLNQTKSLLENISEISVQTKQVNREVLGSMHFKESDLHKEVRMLSGGERVKLLLSMLLLSDANFLILDEPTNYLDIYAMEALETLIKQFAGTVLFVSHDRTFVNHVAEQLLVIENNEMNFHRMTFAEYEESKAPSRITEEDKLILEMRMSEIAAKLMQPNLKPTEKAILEQDYQEIITKRQQFS
Atome Classification :
(20 SA)
-------.........10...-.-------.-...20.....-...30........40------------........50-----......--------..60--.----------------.------------.--------------------..------...70.----------------------------------.---------------------------------------..--------------------------------------------....80........90.....--.--.--.100.-......110.......120..----.....130.......140......------.150.......160.......170.......180.......190.......200.......210.......220........230.......240----------..-..--...250.......260.......270.......280.--..-----------------------------------.....290.......300.......310..-----------..--.---------------.----.------320----------------------.---.----....--------------.------------------------.-----------330.......340------------------------------------------------------------------------------------------.------------------------------------------------------------------------.----------------------------------------------------------------.--...------------------------------------------------------------------...350-----.---..------------------------------------------.---------.-------...360.......370------...-..-..380.......390.......400-.---........410.......420......----.----430.........440.......450------.------.--.....460.......470.......480.......490......----.500.......510.......520.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------MS
T
I
E
I
N
Q
L
K
I
E
V
A
-
D
-------
R
-
V
L
V
EI
P
H
L
L
V
-SKK
A
R
I
G
I
I
GQNGL
G
------------
K
T
T
L
M
E
V
I
AG-----AKEATS--------G
T
V
T--T----------------Q------------G--------------------
K
L
------
A
Y
I
K
Q
L----------------------------------S---------------------------------------TD--------------------------------------------TSTKSG
G
E
K
T
R
K
A
T
Q
H
A
M
RQN--P--
S
--
V
L
L
AD-EPTSNL
D
V
E
S
V
K
H
L
E
R
Q
W
SDF----H
G
A
L
I
I
I
SH
D
R
A
F
L
D
A
L
C
T
E
I
W
E
I------KN
Q
K
I
H
V
YKG
N
Y
H
A
Y
L
E
Q
K
Q
Q
QE
N
Q
A
E
L
A
Y
K
E
F
K
N
K
K
K
Q
L
Q
ASQTHHEIEA
G
R
I
VKPGKRLNNKEASAFKAG-KGT
Q
Q
K
K
Q
H
S
T
I
K
A
L
E
K
R
I
E
R
L----------GN-VE--KPHTTK
P
I
K
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ITPDN
R
V
I
KKG
N
T
I
LSA
K
E
T
A
Y
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A-G--
R
K
-----------------------------------
L
F
ET
K
A
F
S
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KAG
D
K
V
A
L
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GENASG
K
T
T
F
L
K
-----------
E
I
--
I
---------------Q----E------NP-----------------------
N
---
L
----
L
CNP--------------Q------------------------A-----------
K
I
A
Y
F
D
Q
E
LNG--------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------
N
----------------------------------------------------------------
Q
--
T
K
S
------------------------------------------------------------------
L
L
E
N
I
------
S
---
E
I
------------------------------------------
S
---------
V
-------
Q
T
K
Q
V
N
R
E
V
L
G
SMHFK------
E
S
D
-
L
H
-
K
E
V
R
M
LSG
G
E
R
V
K
L
L
L
S
M
L
L
LSD---A---
N
F
L
I
LDEPT
N
Y
L
D
I
Y
A
M
E
A
L
E
T
L
I
K
QF----A----G--
T
V
L
F
V
SH
D
R
T
F
V
N
H
V
A
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Q
L
L
V
I
------E------N--NEM
N
F
H
R
M
T
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A
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Y
EESKAPSRITEE
D
K
L
I
L
E
M
R
M
S
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I
A
A
K
L
MQP----NLK
P
T
E
K
A
I
L
E
Q
D
Y
Q
E
I
I
T
K
R
QQFS
77
HHSearch
86.64
27%
-60
- C1 -
2IW3
7
EF3A_YEAST
A:
[439-978]
-------------
C
E
F
S
L
A
Y
G
-
A
-------
K
-
I
L
L
N
K
T
Q
L
R
L
-
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
------------
K
S
T
L
M
R
A
I
A
N
GQVDG
F
P
T
Q
E
E
--------
C
R
T
V
--
Y
VEHDIDGTHSD-----
T
------------
S
--------------------
V
L
------
D
F
V
F
E
S
GVGT
K
E
A
I
K
D
K
L
I
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F
GFT
D
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M
I
------------
A
---------------------------------------
M
P
--------------------------------------------
I
S
A
L
S
G
G
W
K
M
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L
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N
--
A
--
D
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L
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----
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------
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-------
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---
N
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-----------------------------------------
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----------
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-
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TS
K
P
-----------------------------------
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---------------
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------
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-----------------------
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A
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-------------------------------------------------------------------------------------------
I
------------------------------------------------------------------------
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SH--------------------------------------------------------------
L
--
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K
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P
S
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W
R
F
Q
TGEDRETMDRANRQINEND
A
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A
M
N
K
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K
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T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
N
I
------
G
---
M
K
S
E
R
W
V
P
M
M
SVD
N
A
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
GQF
R
---------
P
-------
L
T
R
K
E
I
E
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H
C
S
M
L
G
L
D
------
P
E
I
V
S
H
-
S
R
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R
G
L
S
G
G
Q
K
V
K
L
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L
A
A
G
T
W
Q
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---
P
---
H
L
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L
D
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P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
E
F
----
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----
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--
G
V
I
I
I
T
H
S
A
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F
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K
N
L
T
E
E
V
W
A
V
------
K
------
D
--
G
R
M
T
P
--------------------------------------------------------------------
78
HHSearch
82.48
25%
-58
- C1 -
3BK7
4
?
A:
[83-548]
---------
A
I
S
I
V
N
L
P
E
Q
L
D
-
E
D
CVHRYG
V
-
N
A
F
V
L
Y
R
L
P
I
V
K
D
G
M
V
V
G
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V
G
P
N
G
T
G
------------
K
T
T
A
V
K
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L
A
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-----
Q
L
I
P
N
L
--------
C
E
D
N
DS
W
D
N
V
I
R
A
F
R--------
G
NEL
Q
N
Y
F
E
R
L
K
N
G
E
I
------------------
R
P
------
V
V
K
P
Q
Y
VDL
L
------------------------------
P
K
A
V
KGK
V
R
E
L
L
K
K
V
DEVGK
F
E
E
V
V
K
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L
ELENVLD-----
R
E
--------------------------------------------
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
--
A
--
H
--
F
Y
F
F
D
-
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P
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S
Y
L
D
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R
L
K
V
A
R
V
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R
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L
A
N
E
-
G
K
A
V
L
V
V
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D
L
A
V
L
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Y
L
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V
V
------
Y
G
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P
-----
G
V
Y
G
I
F
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K
P
K
G
T
R
N
G
I
--
N
E
F
---------
L
Q
G
Y
L
K
D
E
---
N
V
R
F
R
-------------------------------
P
Y
E
I
R
F
T
K
------------------
L
S
----------
E
R
V
D
V
--
E
R
E
T
L
V
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Y
P
R
L
V
K
D
Y
G
-
S
---
F
-----------------------------------
K
L
E
V
E
P
G
E
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R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
-----------
M
L
--
A
---------------
G
VEEP
T
------
E
G
-----------------------
K
---
V
----
E
W
D
----------------------------------------
L
-----------
T
V
A
Y
K
P
Q
Y
I
K
A
--------------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------
Y
--
E
G
T
------------------------------------------------------------------
V
Y
E
L
L
------
S
---
K
I
------------------------------------------
D
---------
S
S
K
L
----
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
------
D
-
L
-
Y
D
-
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
---
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
----
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--
T
A
L
V
V
E
H
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V
L
M
I
D
Y
V
S
D
R
L
I
V
F
------
E
------
G
--
E
------------------------------------------------------------------------
2
PsiBlast_PDB
80.24
34%
-52
- C1 -
4FIN
11
ETTA_ECOLI
A:
[164-534]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
--
P
--
D
--
M
L
L
L
D
-
E
P
T
N
H
L
D
A
E
S
V
A
W
L
E
R
F
L
H
D
F
----
E
G
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
------
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
---------------
E
A
S
Q
-----
E
A
A
R
-----
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
T
K
----
K
G
-----
K
A
R
L
A
R
F
E
E
L
----------
N
S
-
T
E
Y
Q
K
R
N
E
T
N
E
L
-
F
I
P
P
G
P
R
L
---
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
-
D
--
R
L
-----------------------------------
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
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F
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-----------
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--
S
G--------------
Q
----
E
------
Q
P
-----------------------
D
S
G
T
I
----
T
L
G
E
--------------
T
------------------------
V
-----------
K
L
A
S
V
D
Q
F
R
D
S
--------------------------------------------------------------------------------------------
M
------------------------------------------------------------------------
D
----------------------------------------------------------------
N
--
S
K
T
------------------------------------------------------------------
V
W
E
E
V
------
S
GGL
D
I
------------------------------------------
M
KI-------
G
-------
N
T
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
------
G
V
D
-
Q
G
-
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
---
G
---
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
----
G
--
C
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
------
Q
------
D
E-
G
K
V
E
F
F
E
G
N
F
T
E
Y
E
E
Y
K
--------------------------------------------------------
81
HHSearch
80.22
24%
-58
- C1 -
1YQT
4
?
A:
[25-479]
-------------
E
D
C
V
H
R
Y
G
-
V
N------
A
-
F
V
L
Y
R
L
P
-
V
V
-
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
------------
K
S
T
A
V
K
I
L
A
G
-----
Q
L
I
P
N
L
CGDNDS
W
D
G
V
I
R
--
A
F
R--------------
G
------------
N
EL
Q
N
Y
F
E
K
L
K
N
G--------
E
I
R
P
----
V
V
K
P
Q
Y
----------------------------------
V
DLIPKAVKGK
V
I
E
L
L
K
K
A
DETGK
L
E
E
V
V
K
A
L
ELENVLE-
R
E
--------------------------------------------
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
--
A
--
T
--
F
Y
F
F
D
-
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P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
-
G
K
S
V
L
V
V
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H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
------
Y
G
E
P
-----
G
V
Y
G
I
F
S
Q
P
K
G
T
R
N
---------------
G
I
N
E
F
L
R
-------
G
Y
L
-------------------
K
D
E
---
N
-
V
R
-------
F
R
P
Y
----------
E
--
I
K
--
F
T
K
T
G
E
R
V
-------
E
I
--
E
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
G
-
S
---
F
-----------------------------------
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
-----------
M
L
--
A
---------------
G
VEEP
T
------
E
G
-----------------------
K
---
I
----
E
W
D
L
---------------------------------------------------
T
V
A
Y
K
P
Q
Y
I
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----------------------------------------------------------------
Y
--
E
G
T
------------------------------------------------------------------
V
Y
E
L
L
------
S
---
K
I
------------------------------------------
D
---------
A
S
K
L
----
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
------
D
-
L
-
Y
D
-
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
---
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
----
K
--
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
------
E
------
G
--
E
P
-----------------------------------------------------------------------
1
PsiBlast_PDB
80.14
34%
-53
- C1 -
3J5S
-
ETTA_ECOLI
D:
[170-540]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
--
P
--
D
--
M
L
L
L
D
-
E
P
T
N
H
L
D
A
E
S
V
A
W
L
E
R
F
L
H
D
F
----
E
G
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
------
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
---------------
E
A
S
Q
-----
E
A
A
R
-----
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
T
K
G
R
Q
S
K
G
-----
K
A
R
L
A
R
F
E
E
L
----------
N
S
-
T
E
YQ
K
R
N
E
T
N
E
L
-
F
I
P
P
G
P
R
L
---
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
-
D
--
R
L
-----------------------------------
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
-----------
M
I
--
S
G--------------
Q
----
E
------
Q
P
-----------------------
D
SGT
I
----
T
L
G
E
--------------
T
------------------------
V
-----------
K
L
A
S
V
D
Q
F
R
D
S
--------------------------------------------------------------------------------------------
M
------------------------------------------------------------------------
D
----------------------------------------------------------------
N
--
S
K
T
------------------------------------------------------------------
V
W
E
E
V
------
S
G--
G
L
------------------------------------------
D
---------
I
MKIG---
N
T
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
------
G
V
D
-
Q
G
-
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
---
G
---
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
----
G
--
C
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
------
Q
------
D
E-
G
K
V
E
F
F
E
G
N
F
T
E
Y
E
E
Y
K
--------------------------------------------------------
80
HHSearch
76.28
20%
-53
- C1 -
3OZX
5
?
A:
[4-463]
--------------
E
V
I
H
R
Y
K
-
V
N------
G
-
F
K
L
F
G
L
P
T
-
P
-
K
N
N
T
I
L
G
V
L
G
K
N
G
V
G
------------
K
T
T
V
L
K
I
L
A
G
-----
E
I
I
P
N
F
--------
G
D
P
N
--
S
KVG
K
D
E
V
L
K
R
F
R----
G
------------
K
EI
Y
N
Y
F
K
E
L
Y
S
NE
L
K
I
V
H
--
K
I
------
Q
Y
V
E
Y
A
----------------------------------
S
KFLKGT
V
N
E
I
L
T
K
I
DERGK
K
D
E
V
K
E
L
L
NMTNLWN-----
K
D
--------------------------------------------
A
N
I
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
--
A
--
D
--
V
Y
I
F
D
-
Q
P
S
S
Y
L
D
V
R
E
R
M
N
M
A
K
A
I
R
E
L
L
K--
N
K
Y
V
I
V
V
D
H
D
L
I
V
L
D
Y
L
T
D
L
I
H
I
I
------
Y
-
G
E
S
S
V
Y
-
G
R
V
S
K
S
Y
A
A
R
V
G
-----
I
-------------
N
N
F
L
K
-------
G
Y
L
--
P
----
A
-----------
E
N
M
K
--
I
--
R
P
D
E
I
K
F
M
L
K
---------------------------------------
L
K
T
K
M
K
W
T
K
I
I
K
K
L
G
-
D
---
F
-----------------------------------
Q
L
V
V
D
N
G
E
A
K
E
G
E
I
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
-----------
I
L
--
V
---------------
G
EITA
D
------
E
G
-----------------------
S
---
V
----
T
P
E
K
---------------------------------------
Q
-----------
I
L
S
Y
K
P
Q
R
I
F
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------------------------------------------------------
Y
--
D
G
T
------------------------------------------------------------------
V
Q
Q
Y
L
------
E
---
N
A
------------------------------------------
S
---------
K
DALS---
T
S
S
W
F
F
E
E
V
T
K
R
L
N
L
H
------
R
-
L
-
L
E
-
S
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
---
A
---
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
I
V
A
K
A
I
K
R
V
T
R
E
R
K
----
A
--
V
T
F
I
I
D
H
D
L
S
I
H
D
Y
I
A
D
R
I
I
V
F
------
K
------
G
--
E
P
-----------------------------------------------------------------------
79
HHSearch
71.26
20%
-51
- C1 -
3J16
2
RLI1_YEAST
B:
[81-558]
-------------
A
H
V
T
H
R
Y
S
-
A
-------
N
S
F
K
L
H
R
L
P
-
T
P
-
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
------------
K
S
T
A
L
K
I
L
A
G
-----
K
Q
K
P
N
L
--------
G
R
F
D
--
D
----------------
P
PE
W
Q
--------
E
I
I
K
Y
F
RGSEL
Q
N
Y
F
T
K
M
L
E
D
D
I
K
A
I
I
KP
Q
Y
V
D
N
I
----------------------------------
P
R
A
I
KGPVQK
V
G
E
L
L
K
L
R
MEKS
P
E
D
V
K
R
Y
I
K
I
L
QLENVLK
R
D
--------------------------------------------
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
--
A
--
D
--
V
Y
M
F
D
-
E
P
S
S
Y
L
D
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
-
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
------
Y
G
V
P
S
V
-
Y
-
G
V
V
T
L
P
A
S
V
R
E
G
-----
I
N
I
F
---------
L
D
G
H
I
P
A
-----
E
N
L
R
----------------------------------
F
R
T
E
A
L
----------
Q
F
R
I
A
--
D
A
T
--
E
D
L
----
Q
--
N
D
--
S
A
S
R
A
F
S
Y
P
S
L
K
K
T
Q
G
----
D
F
-----------------------------------
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
-----------
L
L
--
A
---------------
G
ALKP
D
------
E
G
-----------------------
Q
---
D
----
I
--
P
--------------
K
------------------------
L
-----------
N
V
S
M
K
P
Q
K
I
A
P
--------------------------------------------------------------------------------------------
K
------------------------------------------------------------------------
F
-------------------------------------------------------------------
P
G
T
------------------------------------------------------------------
V
R
Q
L
F
------
F
---
K
K
------------------------------------------
I
RGQ------
F
-------
L
N
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
------
D
-
I
-
I
D
-
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
---
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
----
K
--
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
------
E
------
G
I
P
S
K
N
-
A
H
A
R
A
P
E
S
L
L
-----------------------------------------------------------
85
HHSearch
64.76
19%
-33
- C1 -
3PIH
4
UVRA_THEMA
A:
[355-902]
------------------------------
V
-
P
K
V
Q
R
W
H
R
E
T
----
E
M
K
E
W
L
E
K
N
F
I
V
------------
Q
R
T
C
S
V
C
G
G
R
-----
R
L
N
R
E
A
--------
L
S
V
K
--
I
----------------
N
------------
G
LN
I
H
E
F
T
E
LS
I
S
E
-------
E
L
------
E
F
L
K
N
L
NLT
E
R
E
R
E
I
V
G
E
L
L
K
E
I
E
K
R
L
E
F
L
V
D
V
GLEYLTL
S
---------------------------------------
R
S
--------------------------------------------
A
T
T
L
S
G
G
E
S
Q
R
I
R
L
A
T
Q
I
G
S
G
--
L
--
T
G
V
I
Y
V
L
D
-
E
P
T
I
G
L
H
P
R
D
T
E
R
L
I
K
T
L
K
K
L
R
D
L
-
G
N
T
V
I
V
V
E
H
D
E
E
V
I
R
-
N
A
D
H
I
I
D
I
G
PGGGT
N
G
G
R
V
V
F
-
Q
G
T
V
D
E
L
L
K
N
P
D
S
S
L
---
T
G
-------------
E
Y
L
------------------------------
S
G
K
---------------
R
K
I
--------------
T
--
V
N
K
-----------
T
R
R
--
L
P
Y
A
S
L
K
I
K
G
V
R
--------
H
N
-----------------------------------
N
L
K
N
I
D
V
E
I
P
L
G
V
F
V
C
V
T
G
V
S
G
S
G
K
S
S
L
V
M
-----------
E
T
--
L
Y
P
A
L
M
N
L
L
HK
T
K
L
P
A
G
E
FDS
I
------
E
G
-----------------------
H
---
E
----
N
I
D
----------------------------------------------------
K
M
I
A
I
D
Q
S
P
I
G
RTPRSN
P
A
T
Y
T
K
V
F
D
E
I
R
S
L
F
A
M
T
P
A
A
K
A
R
GYNKSRFSFNLKGGRCEACQGQG
Y
V
K
I
E
M
L
FL
P
D
V
Y
V
E
CDVCKGKRYN
R
E
T
L
E
ITYKGKN
I
S
D
------------------------------------------------------------------------
I
----------------------------------------------------------------
L
--
D
M
T
------------------------------------------------------------------
V
D
E
A
L
------
E
---
F
F
------------------------------------------
K
---------
N
I------
P
S
I
K
R
T
L
Q
V
L
H
D
V
G
L
G
------
Y
V
K
-
L
G
-
Q
P
A
T
T
L
S
G
G
E
A
Q
R
I
K
L
A
S
E
L
R
K
R
---
D
TG
R
T
L
Y
I
L
D
E
P
T
V
G
L
H
F
E
D
V
R
K
L
V
E
V
L
H
R
L
V
D
R
-
G
----
N
--
T
V
I
V
I
E
H
N
L
D
V
I
K
-
N
A
D
H
I
I
D
L
G
PEGGK
E
------
G
--
G
Y
I
V
-
A
T
G
T
P
E
E
I
A
K
----------------------------------------------------------
86
HHSearch
62.91
27%
-61
- C1 -
1OXX
21
?
K:
[1-228]
-------
M
V
R
I
I
V
K
N
V
S
K
V
F
K
-
K
GK-----
V
-
V
A
L
D
N
V
N
I
N
I
-
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
------------
K
T
T
F
M
R
I
I
A
G
-----
L
D
V
P
S
T
--------
G
E
L
Y
--
F
DDRLVASNGKLIVPPE
D
------------
R
--------------------
K
I
------
G
M
V
F
Q
T
----------------------------------
W
---------------------------------------
A
L
YPNLTAFENIAFPLTNMKMSKEEIRKRVEEVAKILDIHHVLNHF
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
--
P
--
S
--
L
L
L
L
D
-
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
QSRL
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
------
V
K
G
K
L
V
Q
V
-
G
K
P
E
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
HHSearch
60.60
25%
-76
- C1 -
1Z47
1
?
A:
[11-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
--
A
R
-----------------------------------
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
-----------
L
I
--
A
---------------
G
LERP
T
------
K
G
-----------------------
D
---
V
----
W
I
G
G
--------------
K
RVTDLPPQK---------------
R
-----------
N
V
G
L
V
F
Q
N
Y
A
---------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------
F
----------------------------------------------------------------
Q
--
H
M
T
------------------------------------------------------------------
V
Y
D
N
V
------
S
---
F
G
------------------------------------------
L
---------
R
E
K
RVP
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
------
S
-
Y
-
A
N
-
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
---
P
---
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
----
V
--
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
------
H
------
E
--
G
N
V
E
-
Q
F
G
T
P
E
E
V
Y
E
K
---------------------------------------------------------
5
PsiBlast_PDB
59.66
24%
-61
- C1 -
2IW3
4
EF3A_YEAST
A:
[436-672]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
N
C
E
F
S
L
A
Y
G
-
A
--
K
I
-----------------------------------
L
L
N
K
T
Q
L
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
-----------
A
I
--
A
---------------
N
G---
Q
------
V
D
-----------------------
G
---
F
----
P
T
Q
E
--------------
E
------------------------
C
-----------
R
T
V
Y
V
E
H
D
I
D
G
--------------------------------------------------------------------------------------------
T
------------------------------------------------------------------------
H
----------------------------------------------------------------
S
--
D
T
S
------------------------------------------------------------------
V
L
D
F
V
------
F
---
E
S
------------------------------------------
G
---------
V
-------
G
T
K
E
A
I
K
D
K
L
I
E
F
G
F
T
------
D
E
M
-
I
A
-
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
---
A
---
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
----
I
--
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
------
G
--
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
-
K
C
P
A
A
K
A
Y
E
-----
E
L
S
N
T
D
L
E
F
K
F
P
E
P
GYLE
G
V
K
T
K
Q
K
A
I
V
---------------
99
HHSearch
58.97
22%
-65
- C1 -
1Z47
1
?
A:
[13-234]
--------
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
-------
A
-
R
S
V
R
G
V
S
F
Q
I
-
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
------------
K
T
T
I
L
R
L
I
A
G
-----
L
E
R
P
T
K
--------
G
D
V
W
--
I
----------------
G
GKRVTDLPPQK-
R
--------------------
N
V
------
G
L
V
F
Q
N
----------------------------------
Y
---------------------------------------
A
L
FQHMT
V
Y
D
N
V
S
F
G
L
R
E
K
RVP
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
RLESYANRF
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
--
P
--
Q
--
V
L
L
F
D
-
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
------
H
E
G
N
V
E
Q
F
-
G
T
P
E
E
V
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Fugue
58.97
17%
-12
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
-
G
-------
I
-
A
L
I
L
N
A
A
S
D
T
-
F
M
L
S
L
L
K
P
L
L
D
D
G
F
G
KTDRSVLLW
M
P
L
V
V
I
G
L
M
I
L
R
G
-----
I
T
S
Y
I
S
--------
S
Y
C
I
--
S
----------------
W
------------
V
--------------------
S
G
------
K
V
V
M
T
M
----------------------------------
R
---------------------------------------
R
R
--------------------------------------------
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
--
L
--
S
--
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
----
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
------
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
-
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
-
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
FPSVMDSLT
A
G
-
T
I
--
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
-
A
--
I
L
D
SEQEK
D
E
G
K
RVIDRATGD
L
E
F
R
N
V
T
F
T
Y
PGREVP
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
RFYDID
E
G
H
I
--
L
---------------
M
----
D
------
G
H
-----------------------
D
---
L
REYT
L
A
S
L
--------------
R
------------------------
N
-----------
Q
V
A
L
V
S
Q
N
V
H
L
--------------------------------------------------------------------------------------------
F
------------------------------------------------------------------------
N
----------------------------------------------------------------
D
--
T
--------------------------------------------------------------------
V
A
N
N
I
A
YARTE
E
---
Y
S
------------------------------------------
R
---------
E
-------
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
DNGL
D
T
I
-
I
G
-
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
---
S
---
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
----
Q
----
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
------
E
------
D
--
G
-------------------
I
I
V
E
R
G
--------------------------
T
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
4
PsiBlast_PDB
58.79
24%
-65
- C1 -
2IX3
5
EF3A_YEAST
A:
[436-645]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
N
C
E
F
S
L
A
Y
G
-
A
--
K
I
-----------------------------------
L
L
N
K
T
Q
L
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
-----------
A
I
--
A
---------------
N
G---
Q
------
V
D
-----------------------
G
---
F
----
P
T
Q
E
--------------
E
------------------------
C
-----------
R
T
V
Y
V
E
H
D
I
D
G
--------------------------------------------------------------------------------------------
T
------------------------------------------------------------------------
H
----------------------------------------------------------------
S
--
D
T
S
------------------------------------------------------------------
V
L
D
F
V
------
F
---
E
S
------------------------------------------
G
---------
V
-------
G
T
K
E
A
I
K
D
K
L
I
E
F
G
F
T
------
D
E
M
-
I
A
-
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
---
A
---
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
----
I
--
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
------
G
--
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
A
Y
E
E
------------------------------------------------
98
HHSearch
58.58
25%
-58
- C1 -
2IT1
-
?
A:
[1-220]
-------
M
V
E
I
K
L
E
N
I
V
K
K
F
G
-
N
-------
F
-
T
A
L
N
N
I
N
L
K
I
-
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
------------
K
S
T
L
L
Y
T
I
A
G
-----
I
Y
K
P
T
S
--------
G
K
I
Y
--
F
DEKDVTELPPK-----
D
------------
R
--------------------
N
V
------
G
L
V
F
Q
N
----------------------------------
W
---------------------------------------
A
L
YPHMT
V
Y
K
N
I
A
F
P
L
E
L
R
KAP
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
HIDKLLNRY
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
--
P
--
E
--
V
L
L
L
D
-
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
------
R
E
G
E
I
L
Q
V
-
G
T
P
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
HHSearch
58.19
22%
-67
- C1 -
1OXX
21
?
K:
[2-230]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
I
I
V
K
N
V
S
K
V
F
K
-
K
GK
V
V
-----------------------------------
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
-----------
I
I
--
A
---------------
G
LDVP
S
------
T
G
-----------------------
E
---
L
----
Y
F
D
D
RLVASNGKLIVPPE
D
------------------------
R
-----------
K
I
G
M
V
F
Q
T
W
A
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
----------------------------------------------------------------
P
--
N
L
T
------------------------------------------------------------------
A
F
E
N
I
------
A
---
F
P
------------------------------------------
L
---------
T
NMKMSKE
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
------
H
-
V
-
L
N
-
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
---
P
---
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
QSRL
G
----
V
--
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
------
V
------
K
--
G
K
L
V
-
Q
V
G
K
P
E
D
L
Y
D
----------------------------------------------------------
3
PsiBlast_PDB
57.91
24%
-66
- C1 -
2IWH
6
EF3A_YEAST
A:
[436-645]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
N
C
E
F
S
L
A
Y
G
-
A
--
K
I
-----------------------------------
L
L
N
K
T
Q
L
R
L
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
-----------
A
I
--
A
---------------
N
G---
Q
------
V
D
-----------------------
G
---
F
----
P
T
Q
E
--------------
E
------------------------
C
-----------
R
T
V
Y
V
E
H
D
I
D
G
--------------------------------------------------------------------------------------------
T
------------------------------------------------------------------------
H
----------------------------------------------------------------
S
--
D
T
S
------------------------------------------------------------------
V
L
D
F
V
------
F
---
E
S
------------------------------------------
G
---------
V
-------
G
T
K
E
A
I
K
D
K
L
I
E
F
G
F
T
------
D
E
M
-
I
A
-
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
---
A
---
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
----
I
--
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
------
G
--
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
A
Y
E
E
------------------------------------------------
7
PsiBlast_PDB
57.41
28%
-87
- C1 -
1YQT
2
?
A:
[302-484]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
-----------
M
L
A
G
V
---------------
E
----
E
------
P
T
-----------------------
E
---
G
----
K
I
E
W
--------------
D
------------------------
L
-----------
T
V
A
Y
K
P
Q
Y
I
K
A
--------------------------------------------------------------------------------------------
D
------------------------------------------------------------------------
Y
----------------------------------------------------------------
E
GT
V
Y
E
------------------------------------------------------------------
L
L
S
K
I
------
D
---
A
S
------------------------------------------
K
---------
L
-------
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
--------
I
D
-
L
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
---
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
----
M
E
K
N
E
K
--
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
------
E
------
G
--
E
P
G
K
Y
G
R
------------------------------------------------------------------
83
HHSearch
56.70
21%
-31
- C1 -
2VF7
3
?
A:
[377-827]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
LF
G
--
V
--
V
Y
V
L
D
-
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
-
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
R
-
A
D
W
L
V
D
V
G
PEAGE
K
G
G
E
I
L
-
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
----
G
Q
Y
-------------
L
F
-----------------------------
A
--
D
---------------
R
--------------
H
T
--
E
P
H
-----------
T
P
R
--
E
P
A
G
W
L
E
L
N
G
V
T
--------
R
N
-----------------------------------
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
-----------
Q
A
--
L
---------------
V
D
A
--
L
A
A
H
F
GQ-
G
-----------------------
S
---
A
----
R
L
G
G
--------------
D
LAQIT
R
L
V
R
V
D
QKPIGRTPRSN
M
A
T
-----------
Y
T
G
L
F
D
Q
V
R
K
L
--------------------------------------------------------------------------------------------
F
------------------------------------------------------------------------
A
A
T
P
L
A
K
K
R
GYNAGRFSFNVKGGRCEHCQGEGWVMVELLFL
P
S
V
Y
A
P
CPVCHGTRYN
A
E
T
L
E
VEY
R
--
G
K
N
------------------------------------------------------------------
I
A
D
V
L
------
A
---
L
T
------------------------------------------
V
D
E
A
H
D
F
F
A
D
E
-------
S
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
------
Y
L
R
-
L
G
-
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
GRG
G
---
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
-
G
----
N
--
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
PGAGE
D
------
G
--
G
R
L
V
-
A
Q
G
T
P
A
E
V
A
Q
----------------------------------------------------------
84
HHSearch
56.41
19%
-35
- C1 -
2R6F
3
?
A:
[502-942]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
--
L
TG
V
--
L
Y
V
L
D
-
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L-
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
A
D
Y
L
I
D
I
G
PGAGI
H
G
G
E
V
V
A
-
A
G
T
P
E
E
V
M
N
D
P
N
S
L
-------
T
----------
G
Q
Y
L
S
-----------------------------
G
K
--------------
K
F
----------------
I
P
--
I
P
A
E
----------
R
R
R
--
P
D
G
R
W
L
E
V
V
G
A
R
--------
E
H
-----------------------------------
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
-----------
E
V
--
L
---------------
Y
K
A
--
L
------
A
Q
K
LHRAK
A
K
P
G
EHRDIRGLEHLD
K
V
---
I
----
D
I
D
Q
--------------
S
------------------------
P
IGRTPRSN
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
--------------------------------------------------------------------------------------------
F
A
S
T
N
E
A
K
V
R
GYKKGRFSFNVKGGRCEACHGDG
I
I
K
I
E
M
H
FL
P
D
V
Y
V
P
CEVCHGKRYNRETLEVTYKGKN
I
A
E
V
----------------------------------------------------------------
L
--
D
M
T
------------------------------------------------------------------
V
E
D
A
L
------
D
---
F
F
------------------------------------------
A
---------
S
I------
P
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
------
Y
M
K
-
L
G
-
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
---
S
NGR
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
N
-
G
----
D
--
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
------
G
PEGGDR
G
--
G
Q
I
V
-
A
V
G
T
P
E
E
V
A
E
----------------------------------------------------------