@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1371: (2016-03-24 )
VAKEYDVVILGGGTGGYVAAIQAAKNGQKVAVVEKGKVGGTCLHRGCIPTKALLRSAEVLQTVKKASEFGISVEGTAGINFLQAQERKQAIVDQLEKGIHQLFKQGKIDLFVGTGTILGPSIFSPTAGTISVEFEDGSENEMLIPKNLIIATGSKPRTLSGLTIDEEHVLSSDGALNLETLPKSIIIVGGGVIGMEWASMMHDFGVEVTVLEYADRILPTEDKEVAKELARLYKKKKLNMHTSAEVQAASYKKTDTGVEIKAIIKGEEQTFTADKILVSVGRSANTENIGLQNTDIATENGFIQVNDFYQTKESHIYAIGDCIPTIQLAHVAMEEGTIAANYIAGKAAEKLDYDLVPRCIYTSTEIASVGITEEQAKERGHEVKKGKFFFRGIGKALVYGESDGFIKIIADKKTDDILGVSMIGPHVTDMISEAALAQVLNATPWEVGNTIHPHPTLSESFREAALAVDGNAIHG
Atome Classification :
(43 SA)
.........10........20....-....30....-----.-------.-------.--.40........50........60..-.--.---.-..---.-.-70..-...-...80........90........100...-....110.......120----..--......130.....------.--.140.......150.......160.--.--....-----.170.......-180--........190.......200.......210.......220........-230...-....240.......250...--.--.---..260.-...--...---..270.......280.......290.....-.-.-300........310.......320...-.-...330.......340.....--..---350........360-.......370.......380.......390.......400..----.....410.......420.......430.......440.......450.........460.......470...--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
VA
K
E
Y
D
V
V
I
L
GGGTG
G
Y
V
A
A
I
Q
AAK-NG
Q
K
V
A
V
V
EK-----G-------K-------V--
G
G
T
C
L
HRGCI
P
T
K
A
L
L
R
S
A
E
V
L
-
Q
T
-
V
--
K
---
K
-
A
S
---E-F-G
I
S
V
-EGT-AGI
N
F
L
Q
A
Q
E
R
K
Q
A
I
V
D
Q
L
E
K
G
I
H
Q
L
F
KQ-GK
I
D
L
F
V
GTGTILGPS-----IF--SPTA
G
T
I
S
V
E
FEDG------S--EN
E
M
L
IPK
N
L
I
I
ATGSKPRTLS
G
L
T
--I--
D
E
E
H-----VLSSDGAL
N
L
E
-T-L--P
K
S
I
I
I
VGGG
V
I
G
M
E
W
A
S
M
M
H
DFG
V
E
V
T
V
L
E
Y
A
D
R
ILPTE-
D
K
E
V
A
K
E
L
-
A
R
L
Y
K
K
-KKLNMHTS
A
E
V
Q
AASYKKTD--T--G---
V
E
I
--
K
-
A
I
I--KGE---EQTF
T
A
D
K
I
L
V
SVGRSANTENIGLQNTDIA-T-E-N-
G
F
I
Q
V
N
D
FYQTKE
S
H
I
Y
A
IGDCI
P
T
-
I
-
Q
L
A
H
V
AMEEG
T
I
A
A
N
Y
IAG
K
A
--
A
E
---KL-
D
Y
D
LV
P
R
C
IYT-ST
E
I
A
SVGI
T
E
E
Q
A
K
ERGHEVKKG
K
F
F
F
R
GIGK
A
L
V
YGESD
G
----
F
I
K
I
I
ADKKTD
D
I
L
G
V
S
MIG
P
H
V
T
D
M
I
S
E
A
A
L
A
Q
V
LNATPWEVGNT--IHPHP
T
L
S
E
S
F
R
E
A
A
L
AVDGNAIHG--
107
HHSearch
94.33
42%
-94
- C2 -
2EQ6
2
?
A:
[4-461]
-
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
-
L
G
L
K
V
L
A
V
E
A
-----
G
-------
E
-------
V
--
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
-
H
H
-
L
--
K
---
V
-
A
E
---
G
-
F
-
G
L
K
A
---
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
--------------
E
V
E
V
G
--------------
G
E
R
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
---
G
E
D
-----
V
W
D
S
T
R
A
L
K
V
E
E
G
-
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
--
K
K
--
D
G
L
H
---
V
R
L
--
E
-
P
A
E
--
G
G
E
---
G
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
-
V
D
E
-
R
-
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
A
----
F
-
D
Y
-
Q
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
--
115
HHSearch
93.61
40%
-97
- C2 -
1EBD
2
DLDH1_GEOSE
A:
[1-455]
-
A
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
Q
K
V
T
I
V
E
K
-----
G
-------
N
-------
L
--
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
R
Y
-
E
Q
-
A
--
K
---
H
-
S
E
---
E
-
M
-
G
I
K
A
--
E
N
-
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
-
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
--------------
T
V
R
V
V
N
G
D
-------
S
---
A
Q
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
--
F
--
S
-
N
R
-----
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
--
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
-
E
K
Q
M
A
A
I
I
-
K
K
R
L
K
K
-
K
G
V
E
V
V
T
N
A
L
A
K
G
A
E
E
--
R
E
--
D
--
G
---
V
T
V
--
T
-
Y
E
A
--
N
G
E
---
T
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
-
M
T
N
-
R
-
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
G
-
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
--
S
A
----
V
-
D
Y
V
A
I
P
A
V
V
F
S
-
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
----
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
--
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
E
V
A
L
--------
104
HHSearch
93.43
41%
-92
- C2 -
3URH
3
?
A:
[26-486]
----
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
-
L
G
M
K
V
A
V
V
E
K
-----
R
S------
T
-------
Y
--
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
S
E
M
F
-
H
Q
-
A
--
Q
---
H
G
L
E
---
A
-
L
-
G
V
E
V
--
A
N
-
P
K
L
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
G
V
S
F
L
F
K
K
-
N
K
I
D
G
F
Q
G
T
G
K
V
L
G
Q
G
--------------
K
V
S
V
T
N
E
K
G
------
E
---
E
Q
V
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
G
I
P
G
V
E
V
A
F
--
D
E
K
T
-----
I
V
S
S
T
G
A
L
A
L
E
-
K
-
V
--
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
G
M
-
D
G
E
V
A
K
Q
L
-
Q
R
M
L
T
K
-
Q
G
I
D
F
K
L
G
A
K
V
T
G
A
V
K
--
S
G
--
D
G
A
K
---
V
T
F
--
E
-
P
V
K
--
G
G
E
---
A
T
T
L
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
-
L
D
S
-
R
-
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
R
G
-
P
-
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
I
A
G
Q
A
--
G
H
----
V
-
N
Y
D
V
I
P
G
V
V
Y
T
-
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
----
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
--
C
H
A
H
P
T
M
S
E
A
V
K
E
A
A
L
S
T
F
F
-------
39
PsiBlast_CBE
93.18
38%
-92
- C2 -
1EBD
2
DLDH1_GEOSE
B:
[1-451]
-
A
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
Q
K
V
T
I
V
E
K
-----
G
-------
N
-------
L
--
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
R
Y
-
E
Q
-
A
--
K
---
H
-
S
E
---
E
-
M
-
G
I
K
A
-
E
N
V
-
T
-
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
-
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
----------------
T
V
R
V
V
N
G
------
D
--
S
A
Q
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
--
F
--
S
N
-
R
-----
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
--
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
-
E
K
Q
M
A
A
I
I
-
K
K
R
L
K
K
-
K
G
V
E
V
V
T
N
A
L
A
K
G
A
--
E
E
R
E
--
D
--
G
---
V
T
V
--
T
-
Y
E
A
--
N
G
E
---
T
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
-
M
-
T
-
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
G
-
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
--
S
----
A
V
-
D
Y
V
A
I
P
A
V
V
F
S
-
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
----
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
--
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
------------
15
PsiBlast_PDB
92.32
40%
-91
- C2 -
3URH
3
?
A:
[26-486]
----
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
-
L
G
M
K
V
A
V
V
E
K
R----
S
-------
T
-------
Y
--
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
S
E
M
F
-
H
Q
-
A
--
Q
---
H
-
G
L
---
E
A
L
-
G
V
E
V
--
A
N
-
P
K
L
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
G
V
S
F
L
F
K
K
-
N
K
I
D
G
F
Q
G
T
G
K
V
L
G
Q
--------------
G
K
V
S
V
T
N
E
K
G
---------
E
E
Q
V
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
G
I
P
G
V
E
--
V
A
F
D
E
K
T
-----
I
V
S
S
T
G
A
L
A
L
E
-
K
-
V
--
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
G
M
-
D
G
E
V
A
K
Q
L
-
Q
R
M
L
T
K
-
Q
G
I
D
F
K
L
G
A
K
V
T
G
A
V
K
S
G
D
G
--
A
--
K
---
V
T
F
--
E
-
P
V
K
--
G
G
E
---
A
T
T
L
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
-
L
-
D
-
S
R
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
R
G
-
P
-
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
I
A
G
Q
A
--
G
H
----
V
-
N
Y
D
V
I
P
G
V
V
Y
T
-
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
----
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
--
C
H
A
H
P
T
M
S
E
A
V
K
E
A
A
L
S
T
F
F
-------
9
PsiBlast_PDB
92.05
38%
-93
- C2 -
1EBD
2
DLDH1_GEOSE
A:
[1-451]
-
A
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
Q
K
V
T
I
V
E
K
-----
G
-------
N
-------
L
--
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
R
Y
-
E
Q
-
A
--
K
---
H
-
S
E
---
E
-
M
-
G
I
K
A
-
E
N
V
-
T
-
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
-
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
----------------
T
V
R
V
V
N
G
------
D
--
S
A
Q
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
--
F
--
S
N
-
R
-----
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
--
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
-
E
K
Q
M
A
A
I
I
-
K
K
R
L
K
K
-
K
G
V
E
V
V
T
N
A
L
A
K
G
A
--
E
E
R
E
--
D
--
G
---
V
T
V
--
T
-
Y
E
A
--
N
G
E
---
T
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
-
M
-
T
-
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
G
-
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
--
S
----
A
V
-
D
Y
V
A
I
P
A
V
V
F
S
-
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
----
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
--
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
------------
77
PsiBlast_CBE
91.96
38%
-90
- C2 -
3II4
3
DLDH_MYCTU
B:
[5-465]
---
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
L
S
T
A
I
V
E
P
-----
K
-------
Y
-------
W
--
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
-
H
I
F
T
--
K
---
D
-
A
K
---
A
-
F
-
G
I
S
G
-
E
V
T
---
F
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
G
V
H
F
L
M
K
K
-
N
K
I
T
E
I
H
G
Y
G
T
F
--------------
A
D
A
N
T
L
L
V
D
L
N
D
G
------
G
---
T
E
S
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
G
T
S
--
L
--
S
A
N
V
-----
V
T
Y
E
E
Q
I
L
S
R
E
---
L
--
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
-
D
A
D
V
S
K
E
I
-
E
K
Q
F
K
K
-
L
G
V
T
I
L
T
A
T
K
V
E
S
I
A
----
D
--
G
--
G
---
S
Q
V
--
T
-
V
T
V
T
K
D
G
V
---
A
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
-
D
-
R
-
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
--
T
L
---
T
L
G
D
H
R
M
L
P
R
A
T
F
C
-
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
----
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
--
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
I
N
---
106
HHSearch
91.75
40%
-87
- C2 -
1V59
4
DLDH_YEAST
A:
[2-477]
I
N
K
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
-
L
G
F
N
T
A
C
V
E
K
-----
R
G------
K
-------
L
--
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
-
H
Q
-
M
--
H
T--
E
-
A
Q
---
K
-
R
-
G
I
D
V
-
N
G
D
-
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
-
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
--------------
K
I
R
V
T
P
V
D
G
LEGTVK
E
---
D
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
E
K
-----
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
--
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
-
D
G
E
V
A
K
A
T
-
Q
K
F
L
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
S
A
K
R
--
N
D
--
D
K-
N
V
V
E
I
V
V
--
E
-
D
T
K
--
T
N
K
---
Q
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
-
V
D
K
-
R
-
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
G
-
P
-
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
T
G
H
--
G
H
----
V
-
N
Y
N
N
I
P
S
V
M
Y
S
-
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
----
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
--
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
---
31
PsiBlast_CBE
91.64
41%
-88
- C2 -
2EQ9
2
?
E:
[5-460]
--
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
-
L
G
L
K
V
L
A
V
E
A
-----
G
-------
E
-------
V
--
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
-
H
H
-
L
--
K
---
V
-
A
E
---
G
-
F
-
G
L
K
A
-
K
P
E
-
L
D
L
K
K
L
G
G
W
--
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
------------------
E
V
E
V
G
------
G
--
E
R
--
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
--
G
E
D
------
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
--
H
---
V
R
L
--
E
-
P
A
E
--
G
G
E
---
G
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
-
V
D
E
-
R
-
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
----
A
F
-
D
Y
Q
-
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
---
45
PsiBlast_CBE
91.56
39%
-91
- C2 -
1ZY8
2
DLDH_HUMAN
E:
[6-465]
---
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
-
L
G
F
K
T
V
C
I
E
K
-----
N
-------
E
T------
L
--
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
Y
Y
-
H
M
-
A
HG
K
---
D
-
F
A
---
S
-
R
-
G
I
E
M
-
S
-
E
-
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
G
I
A
H
L
F
K
Q
-
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
-----
Q
V
--
T
A
T
K
A
-------
D
G
------
G
---
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
D
T
-----
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
--
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
I
D
M
E
I
S
K
N
F
-
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
-
K
K
S
D
GK
I
--
D
---
V
S
I
--
E
-
A
A
S
--
G
G
K
---
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
-
L
-
D
P
R
-
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
-
P
-
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
A
G
G
A
--
V
H
----
I
-
D
Y
N
C
V
P
S
V
I
Y
T
-
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
----
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
--
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
----------
75
PsiBlast_CBE
91.51
38%
-89
- C2 -
4M52
4
DLDH_MYCTU
C:
[5-465]
---
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
L
S
T
A
I
V
E
P
-----
K
-------
Y
-------
W
--
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
-
H
I
F
T
--
K
---
D
-
A
K
---
A
-
F
-
G
I
S
G
-
E
V
T
---
F
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
G
V
H
F
L
M
K
K
-
N
K
I
T
E
I
H
G
Y
G
T
F
--------------
A
D
A
N
T
L
L
V
D
L
N
D
G
------
G
---
T
E
S
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
G
T
S
--
L
--
S
A
N
V
-----
V
T
Y
E
E
Q
I
L
S
R
E
---
L
--
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
-
D
A
D
V
S
K
E
I
-
E
K
Q
F
K
K
-
L
G
V
T
I
L
T
A
T
K
V
E
S
I
A
----
D
--
G
--
G
---
S
Q
V
--
T
-
V
T
V
TK
D
G
V
---
A
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
-
D
-
R
-
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
--
T
L
---
T
L
G
D
H
R
M
L
P
R
A
T
F
C
-
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
----
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
--
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
I
N
---
18
PsiBlast_PDB
91.42
38%
-85
- C2 -
4M52
4
DLDH_MYCTU
A:
[5-465]
---
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
L
S
T
A
I
V
E
P
-----
K
-------
Y
-------
W
--
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
-
H
I
F
T
--
K
---
D
-
A
K
---
A
-
F
-
G
I
S
G
-
E
V
T
---
F
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
G
V
H
F
L
M
K
K
-
N
K
I
T
E
I
H
G
Y
G
T
F
--------------
A
D
A
N
T
L
L
V
D
L
N
D
G
------
G
---
T
E
S
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
G
T
S
--
L
--
S
A
N
V
-----
V
T
Y
E
E
Q
I
L
S
R
E
---
L
--
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
-
D
A
D
V
S
K
E
I
-
E
K
Q
F
K
K
-
L
G
V
T
I
L
T
A
T
K
V
E
S
I
A
----
D
--
G
--
G
---
S
Q
V
--
T
-
V
T
V
T
K
D
G
V
---
A
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
-
D
-
R
-
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
--
T
L
---
T
L
G
D
H
R
M
L
P
R
A
T
F
C
-
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
----
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
--
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
I
N
---
29
PsiBlast_CBE
91.30
41%
-88
- C2 -
2EQ9
2
?
H:
[5-460]
--
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
-
L
G
L
K
V
L
A
V
E
A
-----
G
-------
E
-------
V
--
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
-
H
H
-
L
--
K
---
V
-
A
E
---
G
-
F
-
G
L
K
A
-
K
P
E
-
L
D
L
K
K
L
G
G
W
--
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
------------------
E
V
E
V
G
------
G
--
E
R
--
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
--
G
E
D
------
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
--
H
---
V
R
L
--
E
-
P
A
E
--
G
G
E
---
G
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
-
V
D
E
-
R
-
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
----
A
F
-
D
Y
Q
-
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
---
7
PsiBlast_PDB
91.02
41%
-88
- C2 -
2EQ9
2
?
A:
[5-460]
--
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
-
L
G
L
K
V
L
A
V
E
A
-----
G
-------
E
-------
V
--
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
-
H
H
-
L
--
K
---
V
-
A
E
---
G
-
F
-
G
L
K
A
-
K
P
E
-
L
D
L
K
K
L
G
G
W
--
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
------------------
E
V
E
V
G
------
G
--
E
R
--
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
--
G
E
D
------
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
--
H
---
V
R
L
--
E
-
P
A
E
--
G
G
E
---
G
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
-
V
D
E
-
R
-
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
----
A
F
-
D
Y
Q
-
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
---
105
HHSearch
90.91
38%
-88
- C2 -
2A8X
3
DLDH_MYCTU
A:
[1-463]
-
M
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
L
S
T
A
I
V
E
P
-----
K
-------
Y
-------
W
--
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
-
H
I
-
F
--
T
K
--
D
-
A
K
---
A
-
F
-
G
I
S
G
---
E
-
V
T
F
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
G
V
H
F
L
M
K
K
-
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
--------------
T
L
L
V
D
L
N
D
G
------
G
---
T
E
S
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
-
G
T
S-
L
--
S
-
A
N
-----
V
V
T
Y
E
E
Q
I
L
S
R
-
E
-
L
--
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
-
D
A
D
V
S
K
E
I
-
E
K
Q
F
K
K
-
L
G
V
T
I
L
T
A
T
K
V
E
S
I
A
D
--
G
G
--
S
--
Q
---
V
T
V
--
T
-
V
T
K
--
D
G
V
---
A
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
-
L
T
D
-
R
-
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
L
T
L
----
G
-
D
H
R
M
L
P
R
A
T
F
C
-
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
----
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
--
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
I
N
---
42
PsiBlast_CBE
90.91
39%
-91
- C2 -
1ZY8
2
DLDH_HUMAN
H:
[6-465]
---
D
A
D
V
T
V
I
G
S
G
P
G
G
Y
V
A
A
I
K
A
A
Q
-
L
G
F
K
T
V
C
I
E
K
-----
N
-------
E
T------
L
--
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
Y
Y
-
H
M
-
A
HG
K
---
D
-
F
A
---
S
-
R
-
G
I
E
M
-
S
-
E
-
V
R
L
N
L
D
K
M
M
E
Q
K
S
T
A
V
K
A
L
T
G
G
I
A
H
L
F
K
Q
-
N
K
V
V
H
V
N
G
Y
G
K
I
T
G
K
N
-----
Q
V
--
T
A
T
K
A
-------
D
G
------
G
---
T
Q
V
I
D
T
K
N
I
L
I
A
T
G
S
E
V
T
P
F
P
G
I
T
--
I
--
D
E
D
T
-----
I
V
S
S
T
G
A
L
S
L
K
-
K
-
V
--
P
E
K
M
V
V
I
G
A
G
V
I
G
V
E
L
G
S
V
W
Q
R
L
G
A
D
V
T
A
V
E
F
L
G
H
V
G
G
V
G
I
D
M
E
I
S
K
N
F
-
Q
R
I
L
Q
K
-
Q
G
F
K
F
K
L
N
T
K
V
T
G
A
T
-
K
K
S
D
GK
I
--
D
---
V
S
I
--
E
-
A
A
S
--
G
G
K
---
A
E
V
I
T
C
D
V
L
L
V
C
I
G
R
R
P
F
T
K
N
L
G
L
E
E
L
G
I
E
-
L
-
D
P
R
-
G
R
I
P
V
N
T
R
F
Q
T
K
I
P
N
I
Y
A
I
G
D
V
V
A
G
-
P
-
M
L
A
H
K
A
E
D
E
G
I
I
C
V
E
G
M
A
G
G
A
--
V
H
----
I
-
D
Y
N
C
V
P
S
V
I
Y
T
-
H
P
E
V
A
W
V
G
K
S
E
E
Q
L
K
E
E
G
I
E
Y
K
V
G
K
F
P
F
A
A
N
S
R
A
K
T
N
A
D
T
D
G
----
M
V
K
I
L
G
Q
K
S
T
D
R
V
L
G
A
H
I
L
G
P
G
A
G
E
M
V
N
E
A
A
L
A
L
E
Y
G
A
S
C
E
D
I
A
R
V
--
C
H
A
H
P
T
L
S
E
A
F
R
E
A
N
L
A
----------
76
PsiBlast_CBE
90.88
38%
-86
- C2 -
4M52
4
DLDH_MYCTU
B:
[5-465]
---
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
L
S
T
A
I
V
E
P
-----
K
-------
Y
-------
W
--
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
-
H
I
F
T
--
K
---
D
-
A
K
---
A
-
F
-
G
I
S
G
-
E
V
T
---
F
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
G
V
H
F
L
M
K
K
-
N
K
I
T
E
I
H
G
Y
G
T
F
--------------
A
D
A
N
T
L
L
V
D
L
N
D
G
------
G
---
T
E
S
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
G
T
S
--
L
--
S
A
N
V
-----
V
T
Y
E
E
Q
I
L
S
R
E
---
L
--
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
-
D
A
D
V
S
K
E
I
-
E
K
Q
F
K
K
-
L
G
V
T
I
L
T
A
T
K
V
E
S
I
A
----
D
--
G
--
G
---
S
Q
V
--
T
-
V
T
V
TK
D
G
V
---
A
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
-
D
-
R
-
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
--
T
L
---
T
L
G
D
H
R
M
L
P
R
A
T
F
C
-
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
----
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
--
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
I
N
---
117
HHSearch
90.87
42%
-91
- C2 -
2YQU
4
?
A:
[1-454]
---
M
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
M
K
V
G
V
V
E
K
-----
E
K------
A
-------
L
--
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
-
Y
E
-
A
--
K
---
K
-
G
----
L
-
L
-
G
A
K
V
--
K
G
-
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
-
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
--------------
K
V
L
V
E
E
-
T
-----------
G
E
E
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
-
W
A
Q-
V
--
D
Y
E
R
-----
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
A
A
-
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
--
E
A
--
K
--
G
---
A
R
V
--
E
--
L
----
E
G
---
G
E
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
-
T
D
E
-
R
-
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
--
G
H
----
V
-
D
Y
Q
A
I
P
S
V
V
Y
T
-
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
--
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
---
33
PsiBlast_CBE
90.78
41%
-87
- C2 -
2EQ9
2
?
B:
[5-460]
--
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
-
L
G
L
K
V
L
A
V
E
A
-----
G
-------
E
-------
V
--
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
-
H
H
-
L
--
K
---
V
-
A
E
---
G
-
F
-
G
L
K
A
-
K
P
E
-
L
D
L
K
K
L
G
G
W
--
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
------------------
E
V
E
V
G
------
G
--
E
R
--
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
--
G
E
D
------
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
--
H
---
V
R
L
--
E
-
P
A
E
--
G
G
E
---
G
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
-
V
D
E
-
R
-
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
----
A
F
-
D
Y
Q
-
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
---
102
HHSearch
90.64
40%
-87
- C2 -
2QAE
2
DLDH_TRYCR
A:
[1-467]
--
N
P
Y
D
V
V
V
I
G
G
G
P
G
G
Y
V
A
S
I
K
A
A
Q
-
L
G
M
K
T
A
C
V
E
K
-----
R
G------
A
-------
L
--
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
L
Y
-
H
D
-
A
--
H
---
A
N
F
A
---
R
-
Y
-
G
L
M
G
-
G
E
G
-
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
V
E
Y
L
F
K
K
-
N
K
V
T
Y
Y
K
G
E
G
S
F
E
T
A
H
--------------
S
I
R
V
N
G
L
D
G
------
K
---
Q
E
M
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
-
F
L
P-
F
--
D
E
K
V
-----
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
--
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
-
D
E
D
V
T
N
A
L
-
V
G
A
L
A
K
N
E
K
M
K
F
M
T
S
T
K
V
V
G
G
T
N
--
N
G
--
D
--
S
---
V
S
L
--
E
V
E
G
-----
K
---
R
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
-
K
N
E
-
R
-
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
G
P
-
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
G
K
P
--
G
H
----
V
-
N
Y
G
V
I
P
A
V
I
Y
T
-
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
----
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
--
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
I
N
---
38
PsiBlast_CBE
90.42
37%
-95
- C2 -
3LAD
2
DLDH_AZOVI
B:
[1-470]
-
S
Q
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
-
L
G
L
K
T
A
L
I
E
K
-----
Y
-------
K
GKEGKTA
L
--
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
F
-
H
E
-
A
--
H
---
E
-
S
F
---
K
-
L
H
G
I
S
T
--
G
E
-
V
A
I
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
V
A
S
L
I
K
A
-
N
G
V
T
L
F
E
G
H
G
K
L
L
--------------
A
G
K
K
V
E
V
T
A
A
D
G
------
S
---
S
Q
V
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
E
I
P
P
A
P
--
V
--
D
Q
D
V
-----
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
--
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
A
V
-
D
E
Q
V
A
K
E
A
-
Q
K
I
L
T
K
-
Q
G
L
K
I
L
L
G
A
R
V
T
G
T
E
V
K
N
K
Q
---------
V
T
V
--
K
-
F
V
D
--
A
E
G
---
E
K
S
Q
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
-
L
D
E
-
R
-
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
R
G
-
A
-
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
I
A
G
H
K
--
A
Q
----
M
-
N
Y
D
L
I
P
A
V
I
Y
T
-
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
----
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
--
V
F
A
H
P
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
---
26
PsiBlast_CBE
90.24
39%
-87
- C2 -
1LPF
2
DLDH_PSEFL
B:
[1-470]
-
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
L
K
T
A
C
I
E
K
YIGKE
G
-------
K
-------
V
AL
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
-
H
E
-
A
--
K
---
E
-
A
F
---
K
-
V
H
G
I
E
A
-
K
G
V
-
T
-
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
-
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
--------------
Q
V
E
V
T
G
L
D
G
---------
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
S
D
D
I
-----
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
--
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
-
D
E
Q
I
A
K
E
A
-
L
K
V
L
T
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
K
K
Q
--
V
--
T
---
V
T
F
--
T
-
D
A
N
--
G
E
Q
---
K
E
T
F
--
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
-
L
D
E
-
R
-
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
G
-
A
-
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
--
A
Q
----
M
-
N
Y
D
L
I
P
S
V
I
Y
T
-
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
----
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
--
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
---
5
PsiBlast_PDB
89.68
41%
-85
- C2 -
2EQ6
2
?
A:
[5-460]
--
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
-
L
G
L
K
V
L
A
V
E
A
-----
G
-------
E
-------
V
--
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
-
H
H
-
L
--
K
---
V
-
A
E
---
G
-
F
-
G
L
K
A
-
K
P
E
-
L
D
L
K
K
L
G
G
W
--
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
------------------
E
V
E
V
G
------
G
--
E
R
--
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
--
G
E
D
------
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
--
H
---
V
R
L
--
E
-
P
A
E
--
G
G
E
---
G
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
-
V
D
E
-
R
-
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
----
A
F
-
D
Y
Q
-
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
---
37
PsiBlast_CBE
89.60
41%
-86
- C2 -
2EQ6
2
?
B:
[5-460]
--
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
-
L
G
L
K
V
L
A
V
E
A
-----
G
-------
E
-------
V
--
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
-
H
H
-
L
--
K
---
V
-
A
E
---
G
-
F
-
G
L
K
A
-
K
P
E
-
L
D
L
K
K
L
G
G
W
--
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
------------------
E
V
E
V
G
------
G
--
E
R
--
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
--
G
E
D
------
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
--
L
--
H
---
V
R
L
--
E
-
P
A
E
--
G
G
E
---
G
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
-
V
D
E
-
R
-
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
----
A
F
-
D
Y
Q
-
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
---
4
PsiBlast_PDB
89.57
39%
-88
- C2 -
1LPF
2
DLDH_PSEFL
A:
[1-470]
-
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
L
K
T
A
C
I
E
K
YIGKE
G
-------
K
-------
V
AL
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
-
H
E
-
A
--
K
---
E
-
A
F
---
K
-
V
H
G
I
E
A
-
K
G
V
-
T
-
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
-
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
--------------
Q
V
E
V
T
G
L
D
G
---------
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
S
D
D
I
-----
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
--
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
-
D
E
Q
I
A
K
E
A
-
L
K
V
L
T
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
E
V
K
K
K
Q
--
V
--
T
---
V
T
F
--
T
-
D
A
N
--
G
E
Q
---
K
E
T
F
--
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
-
L
D
E
-
R
-
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
R
G
-
A
-
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
A
G
H
K
--
A
Q
----
M
-
N
Y
D
L
I
P
S
V
I
Y
T
-
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
----
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
--
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
---
19
PsiBlast_PDB
89.55
39%
-82
- C2 -
1JEH
2
DLDH_YEAST
A:
[2-477]
I
N
K
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
-
L
G
F
N
T
A
C
V
E
K
R----
G
-------
K
-------
L
--
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
H
Q
M
-
H
--
T
---
E
-
A
Q
---
K
-
R
-
G
I
D
V
-
N
G
D
-
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
-
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
-----
K
I
--
R
V
T
----
P
V
D
G
L
E
G
------
T
VK
E
D
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
E
K
-----
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
--
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
-
D
G
E
V
A
K
A
T
-
Q
K
F
L
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
K
--
N
--
V
---
V
E
I
V
V
E
-
D
T
K
--
T
N
K
---
Q
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
-
V
-
D
K
R
-
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
G
-
P
-
M
L
A
H
K
A
E
E
E
G
-
I
A
A
V
E
M
L
K
T
G
--
H
G
---
H
V
-
N
Y
N
N
I
P
S
V
M
Y
S
-
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
----
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
--
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
---
21
PsiBlast_CBE
89.36
41%
-85
- C2 -
2YQU
6
?
B:
[2-454]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
M
K
V
G
V
V
E
K
-----
E
-------
K
A------
L
--
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
-
Y
E
-
A
--
K
---
K
-
G
L
-----
L
-
G
A
K
V
-
K
G
V
-
E
-
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
-
N
G
I
A
R
H
Q
G
T
A
R
F
L
--------------
S
E
R
K
V
L
V
E
-
E
T
G
------
E
--
E
L
E
A
---
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
--
D
Y
E
R
-----
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
A
A
-
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
G
--
A
--
R
---
V
E
L
--
E
-
G
-----
G
E
-----
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
-
T
D
E
-
R
-
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
-
R
G
--
F
G
---
H
V
-
D
Y
Q
A
I
P
S
V
V
Y
T
-
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
--
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
---
2
PsiBlast_PDB
89.32
41%
-86
- C2 -
2YQU
4
?
A:
[2-454]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
M
K
V
G
V
V
E
K
-----
E
-------
K
A------
L
--
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
-
Y
E
-
A
--
K
---
K
-
G
L
-----
L
-
G
A
K
V
-
K
G
V
-
E
-
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
-
N
G
I
A
R
H
Q
G
T
A
R
F
L
--------------
S
E
R
K
V
L
V
E
-
E
T
G
------
E
--
E
L
E
A
---
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
--
D
Y
E
R
-----
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
A
A
-
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
G
--
A
--
R
---
V
E
L
--
E
-
G
-----
G
E
-----
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
-
T
D
E
-
R
-
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
-
R
G
--
F
G
---
H
V
-
D
Y
Q
A
I
P
S
V
V
Y
T
-
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
--
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
---
17
PsiBlast_PDB
89.29
38%
-85
- C2 -
3II4
3
DLDH_MYCTU
A:
[5-465]
---
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
L
S
T
A
I
V
E
P
-----
K
-------
Y
-------
W
--
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
-
H
I
F
T
--
K
---
D
-
A
K
---
A
-
F
-
G
I
S
G
-
E
V
T
---
F
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
G
V
H
F
L
M
K
K
-
N
K
I
T
E
I
H
G
Y
G
T
F
--------------
A
D
A
N
T
L
L
V
D
L
N
D
G
------
G
---
T
E
S
V
T
F
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
G
T
S
--
L
--
S
A
N
V
-----
V
T
Y
E
E
Q
I
L
S
R
E
---
L
--
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
-
D
A
D
V
S
K
E
I
-
E
K
Q
F
K
K
-
L
G
V
T
I
L
T
A
T
K
V
E
S
I
A
----
D
--
G
--
G
---
S
Q
V
--
T
-
V
T
V
T
K
D
G
V
---
A
Q
E
L
K
A
E
K
V
L
Q
A
I
G
F
A
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
T
-
D
-
R
-
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
--
T
L
---
T
L
G
D
H
R
M
L
P
R
A
T
F
C
-
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
----
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
--
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
I
N
---
1
PsiBlast_PDB
89.22
41%
-85
- C2 -
2EQ7
3
?
A:
[2-452]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
M
K
V
G
V
V
E
K
-----
E
-------
K
A------
L
--
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
-
Y
E
-
A
--
K
---
K
-
G
L
-----
L
-
G
A
K
V
-
K
G
V
-
E
-
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
-
N
G
I
A
R
H
Q
G
T
A
R
F
L
--------------
S
E
R
K
V
L
V
E
-
E
T
G
------
E
--
E
L
E
A
---
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
--
D
Y
E
R
-----
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
A
A
-
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
G
--
A
--
R
---
V
E
L
--
E
-
G
-----
G
E
-----
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
-
T
D
E
-
R
-
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
-
R
G
--
F
G
---
H
V
-
D
Y
Q
A
I
P
S
V
V
Y
T
-
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
--
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
-----
22
PsiBlast_CBE
89.08
41%
-84
- C2 -
2EQ7
3
?
B:
[2-452]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
-
L
G
M
K
V
G
V
V
E
K
-----
E
-------
K
A------
L
--
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
-
Y
E
-
A
--
K
---
K
-
G
L
-----
L
-
G
A
K
V
-
K
G
V
-
E
-
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
-
N
G
I
A
R
H
Q
G
T
A
R
F
L
--------------
S
E
R
K
V
L
V
E
-
E
T
G
------
E
--
E
L
E
A
---
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
--
D
Y
E
R
-----
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
A
A
-
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
G
--
A
--
R
---
V
E
L
--
E
-
G
-----
G
E
-----
V
L
E
A
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
-
T
D
E
-
R
-
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
-
R
G
--
F
G
---
H
V
-
D
Y
Q
A
I
P
S
V
V
Y
T
-
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
--
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
-----
103
HHSearch
88.61
39%
-94
- C2 -
3LAD
2
DLDH_AZOVI
A:
[1-471]
-
S
Q
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
-
L
G
L
K
T
A
L
I
E
K
-----
Y
KGKEGKT
A
-------
L
--
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
F
-
H
E
-
A
--
H
---
E
S
F
K
---
L
-
H
-
G
I
S
T
--
G
E
-
V
A
I
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
V
A
S
L
I
K
A
-
N
G
V
T
L
F
E
G
H
G
K
L
L
A
G
K
--------------
K
V
E
V
T
A
A
D
G
------
S
---
S
Q
V
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
E
I
P
-
P
A
P-
V
--
D
Q
D
V
-----
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
--
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
A
V
-
D
E
Q
V
A
K
E
A
-
Q
K
I
L
T
K
-
Q
G
L
K
I
L
L
G
A
R
V
T
G
T
E
V
--
K
N
--
K
--
Q
---
V
T
V
--
K
-
F
V
D
--
A
E
G
---
E
K
S
Q
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
-
L
D
E
-
R
-
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
R
G
-
A
-
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
I
A
G
H
K
--
A
Q
----
M
-
N
Y
D
L
I
P
A
V
I
Y
T
-
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
----
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
--
V
F
A
H
P
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
V
--
20
PsiBlast_PDB
88.34
39%
-81
- C2 -
1V59
4
DLDH_YEAST
A:
[2-477]
I
N
K
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
-
L
G
F
N
T
A
C
V
E
K
R----
G
-------
K
-------
L
--
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
H
Q
M
-
H
--
T
---
E
-
A
Q
---
K
-
R
-
G
I
D
V
-
N
G
D
-
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
-
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
-----
K
I
--
R
V
T
----
P
V
D
G
L
E
G
------
T
VK
E
D
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
E
K
-----
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
--
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
-
D
G
E
V
A
K
A
T
-
Q
K
F
L
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
K
--
N
--
V
---
V
E
I
V
V
E
-
D
T
K
--
T
N
K
---
Q
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
-
V
-
D
K
R
-
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
G
-
P
-
M
L
A
H
K
A
E
E
E
G
-
I
A
A
V
E
M
L
K
T
G
--
H
G
---
H
V
-
N
Y
N
N
I
P
S
V
M
Y
S
-
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
----
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
--
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
---
78
PsiBlast_CBE
87.97
39%
-81
- C2 -
1V59
3
DLDH_YEAST
B:
[2-477]
I
N
K
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
-
L
G
F
N
T
A
C
V
E
K
R----
G
-------
K
-------
L
--
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
H
Q
M
-
H
--
T
---
E
-
A
Q
---
K
-
R
-
G
I
D
V
-
N
G
D
-
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
-
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
-----
K
I
--
R
V
T
----
P
V
D
G
L
E
G
------
T
VK
E
D
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
E
K
-----
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
--
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
-
D
G
E
V
A
K
A
T
-
Q
K
F
L
K
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
K
--
N
--
V
---
V
E
I
VV
E
-
D
T
K
--
T
N
K
---
Q
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
-
V
-
D
K
R
-
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
G
-
P
-
M
L
A
H
K
A
E
E
E
G
-
I
A
A
V
E
M
L
K
T
G
--
H
G
---
H
V
-
N
Y
N
N
I
P
S
V
M
Y
S
-
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
----
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
--
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
---
101
HHSearch
87.82
33%
-90
- C2 -
1LVL
2
DLDH1_PSEPU
A:
[3-457]
-
T
I
Q
T
T
L
L
I
I
G
G
G
P
G
G
Y
V
A
A
I
R
A
G
Q
-
L
G
I
P
T
V
L
V
E
G
-----
Q
-------
A
-------
L
--
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
H
V
A
E
Q
F
-
H
Q
-
A
--
S
---
R
-
F
T
E
PS
P
-
L
-
G
I
S
V
--
A
S
-
P
R
L
D
I
G
Q
S
V
A
W
K
D
G
I
V
D
R
L
T
T
G
V
A
A
L
L
K
K
-
H
G
V
K
V
V
H
G
W
A
K
V
L
D
G
K
--------------
Q
V
E
V
D
--------------
G
Q
R
I
Q
C
E
H
L
L
L
A
T
G
S
S
S
V
E
L
P
-
M
L
P-
L
--
G
-
G
P
-----
V
I
S
S
T
E
A
L
A
P
K
-
A
-
L
--
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
L
G
A
Q
V
S
V
V
E
A
R
E
R
I
L
P
T
Y
-
D
S
E
L
T
A
P
V
-
A
E
S
L
K
K
-
L
G
I
A
L
H
L
G
H
S
V
E
G
Y
E
N
--
G
------
C
---
L
L
A
--
N
-
D
G
---
K
G
G
---
Q
L
R
L
E
A
D
R
V
L
V
A
V
G
R
R
P
R
T
K
G
F
N
L
E
C
L
D
L
K
-
M
-
N
-
G
-
A
A
I
A
I
D
E
R
C
Q
T
S
M
H
N
V
W
A
I
G
D
V
A
G
E
-
P
-
M
L
A
H
R
A
M
A
Q
G
E
M
V
A
E
I
I
A
G
K
A
--
R
R
----
F
-
E
P
A
A
I
A
A
V
C
F
T
-
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
L
D
C
I
V
A
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
----
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
A
V
S
E
L
S
T
A
F
A
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
--
I
H
A
H
P
T
L
G
E
A
V
Q
E
A
A
L
R
A
L
G
H
A
L
H
---
79
PsiBlast_CBE
87.42
39%
-82
- C2 -
1JEH
2
DLDH_YEAST
B:
[2-477]
I
N
K
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
-
L
G
F
N
T
A
C
V
E
K
R----
G
-------
K
-------
L
--
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
H
Q
M
-
H
--
T
---
E
-
A
Q
---
K
-
R
-
G
I
D
V
-
N
G
D
-
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
-
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
-----
K
I
--
R
V
T
----
P
V
D
G
L
E
G
------
T
VK
E
D
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
E
K
-----
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
--
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
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M
-
D
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V
A
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-
Q
K
F
L
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K
-
Q
G
L
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F
K
L
S
T
K
V
I
S
A
K
R
N
D
D
K
--
N
--
V
---
V
E
I
VV
E
-
D
T
K
--
T
N
K
---
Q
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
-
V
-
D
K
R
-
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
F
G
-
P
-
M
L
A
H
K
A
E
E
E
G
-
I
A
A
V
E
M
L
K
T
G
--
H
G
---
H
V
-
N
Y
N
N
I
P
S
V
M
Y
S
-
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
----
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
--
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
---
91
Fugue
86.68
39%
-99
- C2 -
3LAD
2
DLDH_AZOVI
A:
[1-472]
-
S
Q
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
-
G
L
K
T
A
L
I
E
K
-----
Y
-------
K
GKEGKTA
L
--
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
F
-
H
E
-
A
--
H
ESF
K
------
L
-
H
-
G
I
S
T
-
G
--
E
V
A
I
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
V
A
S
L
I
K
A
N
G
-
V
T
L
F
E
-
G
H
G
K
L
L
--AGK
K
V
E
V
--
T
A
A
----------
D
------
G
--
S
S
Q
V
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
E
I
P
P
A
P
--
V
--
D
Q
--DVIVD---
S
T
G
A
L
D
F
Q
----NV
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
A
-V
D
E
Q
V
A
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A
-
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K
I
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-
Q
G
L
K
I
L
L
G
A
R
V
T
G
T
E
V
K
N
-
K
Q-
V
--
T
---
V
K
F
--
V
-
D
A
------
E
G
E
K
S
Q
A
-
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
-
L
D
E
-
R
-
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
R
G
--A
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
I
A
G
------HK
A
Q
M
-
N
Y
D
L
I
P
A
V
I
Y
T
H-
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
----
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
DT
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
A
--
L
S
E
A
L
H
E
A
A
L
A
V
S
G
-
H
A
I
H
VA
73
PsiBlast_CBE
83.23
38%
-81
- C2 -
2QAE
2
DLDH_TRYCR
B:
[17-467]
------------------
A
S
I
K
A
A
Q
-
L
G
M
K
T
A
C
V
E
K
R----
G
-------
A
-------
L
--
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
L
Y
-
H
D
-
A
--
H
A--
N
-
F
A
---
R
-
Y
-
G
L
M
G
-
G
E
G
-
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
V
E
Y
L
F
K
K
-
N
K
V
T
Y
Y
K
G
E
G
S
F
--------------
E
T
A
H
S
I
R
V
N
G
L
D
G
------
K
--
Q
-
E
M
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
F
L
P
--
F
--
D
E
K
V
-----
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
--
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
-
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
-
E
K
M
K
F
M
T
S
T
K
V
V
G
G
T
N
N
G
D
S
--
V
--
S
---
L
E
V
--
E
-
G
------
K
---
R
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
-
E
-
R
-
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
G
P
-
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
G
K
P
--
G
H
----
V
-
N
Y
G
V
I
P
A
V
I
Y
T
-
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
----
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
--
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
I
N
---
90
PsiBlast_CBE
82.26
36%
-82
- C2 -
1BHY
1
?
A:
[6-467]
---
E
Y
D
V
V
V
L
G
G
G
P
G
G
Y
S
A
A
F
A
A
A
D
-
E
G
L
K
V
A
I
V
E
R
-----
Y
-------
K
T------
L
--
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
N
A
A
V
I
-
D
E
-
V
--
R
---
H
-
L
A
---
A
-
N
-
G
I
K
Y
P
E
P
E
-
L
D
I
D
M
L
R
A
Y
--
K
D
G
V
V
S
R
L
T
G
G
L
A
G
M
A
K
S
-
R
K
V
D
V
I
Q
G
D
G
Q
F
L
D
P
H
-----
H
L
EV
S
L
T
A
G
D
A
Y
E
Q
A
A
P
T
------
G
--
E
K
K
I
V
A
F
K
N
C
I
I
A
A
G
S
R
V
T
K
L
P
F
I
P
-----
E
D
P
R
-----
I
I
D
S
S
G
A
L
A
L
K
-
E
-
V
--
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
L
G
S
R
L
D
V
V
E
M
M
D
G
L
M
Q
G
A
-
D
R
D
L
V
K
V
W
-
Q
K
Q
N
E
Y
-
R
F
D
N
I
M
V
N
T
K
T
V
A
V
E
P
K
E
D
G
--
V
--
Y
---
V
T
F
--
E
G
A
N
A
--
P
K
E
---
P
Q
R
Y
--
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
S
A
E
K
A
G
V
A
V
T
-
D
-
R
-
G
F
I
E
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
I
V
G
Q
-
P
-
M
L
A
H
K
A
V
H
E
G
H
V
A
A
E
N
C
A
G
H
K
--
A
----
Y
F
-
D
A
R
V
I
P
G
V
A
Y
T
-
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
A
R
K
I
T
K
A
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
K
P
----
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
V
G
P
N
G
G
D
M
I
G
E
V
Y
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
--
I
H
P
H
P
T
L
G
E
S
I
G
M
A
A
------------
87
PsiBlast_CBE
81.98
32%
-88
- C2 -
4JDR
9
DLDH_ECOLI
A:
[9-462]
------
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
-
L
G
L
E
T
V
I
V
E
R
Y----
N
-------
T
-------
L
--
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
V
A
K
V
I
-
E
E
-
A
--
K
---
A
-
L
A
---
E
-
H
-
G
I
-
V
-
F
G
E
-
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
L
A
G
M
A
K
G
-
R
K
V
K
V
V
N
G
L
G
K
F
T
G
--------------
A
N
T
L
E
V
E
G
E
N
G
----------
K
T
V
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
Q
L
P
F
I
P
--
H
--
E
D
P
R
-----
I
W
D
S
T
D
A
L
E
L
K
-
E
-
V
--
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
-
D
K
D
I
V
K
V
F
-
T
K
R
I
S
K
-
K
-
F
N
L
M
L
E
T
K
V
T
A
V
E
A
K
E
D
G
--
I
--
Y
---
V
T
M
--
E
-
G
K
---
K
A
P
---
A
E
P
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
-
V
-
D
-
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
G
Q
-
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
I
A
G
K
K
---
H
---
Y
F
-
D
P
K
V
I
P
S
I
A
Y
T
-
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
----
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
--
I
H
A
H
P
T
L
H
E
S
V
G
L
A
A
E
V
F
E
G
S
------
86
PsiBlast_CBE
81.80
32%
-88
- C2 -
4JDR
5
DLDH_ECOLI
B:
[9-462]
------
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
-
L
G
L
E
T
V
I
V
E
R
Y----
N
-------
T
-------
L
--
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
V
A
K
V
I
-
E
E
-
A
--
K
---
A
-
L
A
---
E
-
H
-
G
I
-
V
-
F
G
E
-
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
L
A
G
M
A
K
G
-
R
K
V
K
V
V
N
G
L
G
K
F
T
G
--------------
A
N
T
L
E
V
E
G
E
N
G
----------
K
T
V
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
Q
L
P
F
I
P
--
H
--
E
D
P
R
-----
I
W
D
S
T
D
A
L
E
L
K
-
E
-
V
--
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
-
D
K
D
I
V
K
V
F
-
T
K
R
I
S
K
-
K
-
F
N
L
M
L
E
T
K
V
T
A
V
E
A
K
E
D
G
--
I
--
Y
---
V
T
M
--
E
-
G
K
---
K
A
P
---
A
E
P
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
-
V
-
D
-
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
G
Q
-
P
-
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
I
A
G
K
K
---
H
---
Y
F
-
D
P
K
V
I
P
S
I
A
Y
T
-
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
----
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
--
I
H
A
H
P
T
L
H
E
S
V
G
L
A
A
E
V
F
E
G
S
------
89
PsiBlast_CBE
81.22
36%
-81
- C2 -
1OJT
1
?
A:
[6-467]
---
E
Y
D
V
V
V
L
G
G
G
P
G
G
Y
S
A
A
F
A
A
A
D
-
E
G
L
K
V
A
I
V
E
R
-----
Y
-------
K
T------
L
--
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
N
A
A
V
I
-
D
E
-
V
--
R
---
H
-
L
A
---
A
-
N
-
G
I
K
Y
P
E
P
E
-
L
D
I
D
M
L
R
A
Y
--
K
D
G
V
V
S
R
L
T
G
G
L
A
G
M
A
K
S
-
R
K
V
D
V
I
Q
G
D
G
Q
F
L
D
P
H
-----
H
L
EV
S
L
T
A
G
D
A
Y
E
Q
A
A
P
T
------
G
--
E
K
K
I
V
A
F
K
N
C
I
I
A
A
G
S
R
V
T
K
L
P
-
F
I
--
P
--
E
D
P
R
-----
I
I
D
S
S
G
A
L
A
L
K
-
E
-
V
--
P
G
K
L
L
I
I
G
G
G
I
I
G
L
E
M
G
T
V
Y
S
T
L
G
S
R
L
D
V
V
E
M
M
D
G
L
M
Q
G
A
-
D
R
D
L
V
K
V
W
-
Q
K
Q
N
E
Y
-
R
F
D
N
I
M
V
N
T
K
T
V
A
V
E
P
K
E
D
G
--
V
--
Y
---
V
T
F
--
E
G
A
N
A
--
P
K
E
---
P
Q
R
Y
--
D
A
V
L
V
A
A
G
R
A
P
N
G
K
L
I
S
A
E
K
A
G
V
A
V
T
-
D
-
R
-
G
F
I
E
V
D
K
Q
M
R
T
N
V
P
H
I
Y
A
I
G
D
I
V
G
Q
-
P
-
M
L
A
H
K
A
V
H
E
G
H
V
A
A
E
N
C
A
G
H
K
--
A
----
Y
F
-
D
A
R
V
I
P
G
V
A
Y
T
-
S
P
E
V
A
W
V
G
E
T
E
L
S
A
K
A
S
A
R
K
I
T
K
A
N
F
P
W
A
A
S
G
R
A
I
A
N
G
C
D
K
P
----
F
T
K
L
I
F
D
A
E
T
G
R
I
I
G
G
G
I
V
G
P
N
G
G
D
M
I
G
E
V
C
L
A
I
E
M
G
C
D
A
A
D
I
G
K
T
--
I
H
P
H
P
T
L
G
E
S
I
G
M
A
A
------------
16
PsiBlast_PDB
80.75
38%
-81
- C2 -
2QAE
2
DLDH_TRYCR
A:
[17-467]
------------------
A
S
I
K
A
A
Q
-
L
G
M
K
T
A
C
V
E
K
R----
G
-------
A
-------
L
--
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
L
Y
-
H
D
-
A
--
H
A--
N
-
F
A
---
R
-
Y
-
G
L
M
G
-
G
E
G
-
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
V
E
Y
L
F
K
K
-
N
K
V
T
Y
Y
K
G
E
G
S
F
--------------
E
T
A
H
S
I
R
V
N
G
L
D
G
------
K
--
Q
-
E
M
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
F
L
P
--
F
--
D
E
K
V
-----
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
--
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
-
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
-
E
K
M
K
F
M
T
S
T
K
V
V
G
G
T
N
N
G
D
S
--
V
--
S
---
L
E
V
--
E
-
G
------
K
---
R
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
-
E
-
R
-
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
G
P
-
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
A
G
K
P
--
G
H
----
V
-
N
Y
G
V
I
P
A
V
I
Y
T
-
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
----
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
--
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
I
N
---