@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1404: (2016-03-24 )
MAKHIVELTDALSNKIAAGEVVERPASVVKELVENAIDAGSTVIDILVEEAGLNKITIIDNGSGIEEEDVATAFLRHATSKIKNEADLFRVHTLGFRGEALPSIASVSHLAMETSTGETKGTSISLEGGKIIEQKSGHARKGTQIEVSQLFFNTPARLKYLKSLPTELGNITDILNRLALAHPDISFRFSHNGKPLLQTNGNGDLRQVIAAIYGISIAKKSIPVKAESLDFKISGYAVLPEVNRSNRNYISTIINGRFIKNFALVKAIQEGYHTLLPIGRFPIIVLQIEMDPIIVDVNVHPAKLEVRLSKEKELGQLISQMIKEAFHKLQLIPEGEISKKQKEVQKSEQIQMSFEENKPAKEIPTLFSKPTIPEYVPSDEDAPREDDFILETMPPYEPQAEQEEHSKERIPKMYPIGQMHATYIFAQNENGLYIIDQHAAQERIKYEFYREKIGEVSRELQELLVPIVLEFPADEYVRLEEQKAKLEEVGVFLENFGQNSFIIRAHPTWFPKDQEEEMLREIIDEALSAPSISIHKLREDTAIMMSCKKSIKANHYLTTQDMEALLDTLREASDPFTCPHGRPVIIQYSTYELEKMFKRVM
Atome Classification :
(22 SA)
---.........10........20..---.......30........40........50........60........70........80........---90........100.......110..-..--.-..120......-.--.-130-.-........----140........150.......-160-.......170.......180.....---..190--..-----.--.-----....200-.---........210..---------.....220..----------------..------------.--..-230...--...--...240----.---......250..-......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MA
K
H
I
V
E
L
T
D
A
LSNKIAA
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
AIDAG
S
T
V
I
D
I
L
V
E
EAGL
N
K
I
T
I
IDNGSGI
E
E
E
D
V
A
T
A
F
L
R
H
A
T
S
K
IKNEA
D
L
F
---
R
V
H
TLGFRGEAL
P
S
I
A
S
V
S
H
L
A
M
ET-ST--G-ETK-G
T
S
I
S
LE-G--
G
-
K
---
I
-
I
EQKSGHA----R-KG
T
Q
I
E
V
S
Q
L
FFN
T
P
A
R
L
K
-
Y
L
K
-
S
L
P
T
ELG
N
I
T
D
I
L
N
R
L
ALAHP
D
I
S
F
---
R
FSH---NG-----
K
--
P
-----
L
L
Q
TN---G---N
G
D
L
R
Q
V
I
A
A
I
Y
G
---------
I
SIAKKSIPV----------------KA------------E--
S
L
-
D
--
F
K
I--SG
Y
--
A
VLPEV----N---RSNR
N
Y
I
S
-
T
I
-ING
R
F
I
K
N
F
A
L
V
K
A
I
Q
EG
Y
H
T
LLPIGRF
P
I
I
V
L
Q
I
EMD
P
I
I
V
D
V
NVHP
A
K
L
E
V
R
LS
K
E
K
E
L
G
Q
L
I
S
Q
M
I
K
E
A
F
H
K
LQLIPEG
E
I
S
K
K
Q
K
E
V
Q
K
S
E
Q
I
Q
M
S
FEENK
P
A
K
EI
P
T
L
FSKPTIPEYVPSDEDAPRED
D
F
I
LETMPPYEPQ
A
E
Q
E
E
H
S
K
E
RIPKMYPIGQ
M
H
A
T
Y
I
F
A
QNEN
G
L
Y
I
IDQHA
A
Q
E
R
I
K
Y
E
F
Y
R
E
K
I
G
E
V
S
R
E
L
Q
E
L
L
V
P
I
V
LEFP
A
D
E
Y
V
R
L
E
E
Q
K
A
K
L
E
E
V
G
V
F
L
E
NFGQN
S
F
I
I
RAHPTWFPKD
Q
E
E
E
M
L
R
E
I
I
D
E
A
LSAPS
I
S
I
H
KLRED
T
A
I
M
M
S
C
K
K
SIKANHYL
T
T
Q
D
M
E
A
L
L
D
T
L
R
EASDPFTCPHG
R
P
V
I
I
QYS
T
Y
E
L
E
K
M
F
K
RVM
31
HHSearch
92.65
40%
-84
- C3 -
1B63
4
MUTL_ECOLI
A:
[3-333]
-----
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
-
R
T
--
A
E
Q
Q
E
-
A
W
Q
A
Y
A
E
-
G
--
R
-
D
---
M
N
V
T
V
K
P
A
A
H
----
P
-
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
---
N
L
S
H
---
N
G
-----
K
--
I
-----
V
R
Q
Y
R
A
VP
E
---
G
G
Q
K
E
R
R
L
G
A
I
C
G
---------
T
A
F
L
E
Q
A
L
A
I
----------------
E
W
------------
Q
--
H
G
-
D
--
L
T
L
--
R
G
W
--
V
A
D
P
N
H
T---
T
---
P
A
L
A
E
I
Q
Y
-
C
Y
-
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
91.93
39%
-87
- C3 -
1B63
4
MUTL_ECOLI
A:
[1-333]
---
S
H
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
-
E
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
--
E
-
Q
Q
E
-
A
W
Q
A
Y
A
E
-
G
RD
M
-
N
---
V
--
T
V
K
P
A
A
H
----
P
-
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
-R
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
---
N
L
S
H
---
N
---------
G
KIV
R
Q
Y
R
A
V
P
---
E
---
G
G
Q
K
E
R
R
L
G
A
I
C
G
---------
T
A
F
L
E
Q
A
L
A
I
----------------
E
W
------------
Q
--
H
-G
D
--
L
T
L
--
R
G
W
--
V
A
D
P
N
------HTT
P
A
L
A
E
I
Q
Y
-
C
Y
-
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
L
S
V
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
91.41
40%
-81
- C3 -
1NHJ
3
MUTL_ECOLI
A:
[12-328]
--------------
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
P
S
I
S
S
V
S
R
L
T
L
T
S
-
R
T
--
A
-
E
Q
Q
-
E
A
W
Q
A
Y
A
-
E
--
G
-
R
DM
N
V
-
T
V
K
P
A
A
H
P
------
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
---
N
L
S
H
---
N
G
-----
K
--
I
-----
V
R
Q
Y
R
---
A
VPE
G
G
Q
K
E
R
R
L
G
A
I
C
G
---------
T
A
F
L
E
Q
A
L
A
I
----------------
E
W
------------
Q
--
H
G
-
D
--
L
T
L
--
R
G
W
--
V
A
D
P
N
H
----
T
---
T
P
A
L
A
E
I
Q
Y
C
Y
-
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
90.77
40%
-85
- C3 -
1NHI
5
MUTL_ECOLI
A:
[12-328]
--------------
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
-
R
T
--
A
-
E
Q
Q
-
E
A
W
Q
A
Y
A
-
E
--
G
-
R
DM
N
V
-
T
V
K
P
A
A
H
P
------
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
---
N
L
S
H
---
N
G
-----
K
--
I
-----
V
R
Q
Y
R
---
A
V
P
E
G
G
Q
K
E
R
R
L
G
A
I
C
G
---------
T
A
F
L
E
Q
A
L
A
I
----------------
E
W
------------
Q
--
H
G
-
D
--
L
T
L
--
R
G
W
--
V
A
D
P
N
H
----
T
---
T
P
A
L
A
E
I
Q
Y
C
Y
-
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
90.20
40%
-82
- C3 -
1B63
4
MUTL_ECOLI
A:
[12-328]
--------------
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
-
R
T
--
A
-
E
Q
Q
-
E
A
W
Q
A
Y
A
-
E
--
G
-
R
DM
N
V
-
T
V
K
P
A
A
H
P
------
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
---
N
L
S
H
---
N
G
-----
K
--
I
-----
V
R
Q
Y
R
---
A
VPE
G
G
Q
K
E
R
R
L
G
A
I
C
G
---------
T
A
F
L
E
Q
A
L
A
I
----------------
E
W
------------
Q
--
H
G
-
D
--
L
T
L
--
R
G
W
--
V
A
D
P
N
H
----
T
---
T
P
A
L
A
E
I
Q
Y
C
Y
-
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
88.23
40%
-82
- C3 -
1NHH
8
MUTL_ECOLI
A:
[12-328]
--------------
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
-
R
T
--
A
-
E
Q
Q
-
E
A
W
Q
A
Y
A
-
E
--
G
-
R
DM
N
V
-
T
V
K
P
A
A
H
P
------
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
---
N
L
S
H
---
N
G
-----
K
--
I
-----
V
R
Q
Y
R
---
A
V
P---
Q
K
E
R
R
L
G
A
I
C
G
---------
T
A
F
L
E
Q
A
L
A
I
----------------
E
W
------------
Q
--
H
G
-
D
--
L
T
L
--
R
G
W
--
V
A
D
P
N
H
----
T
---
T
P
A
L
A
E
I
Q
Y
C
Y
-
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
--
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
A
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
85.04
40%
-66
- C- -
1B62
2
MUTL_ECOLI
A:
[16-332]
--------------
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
-
R
T
--
A
-
E
Q
Q
-
E
A
W
Q
A
Y
A
-
E
--
G
-
R
DM
N
V
-
T
V
K
P
A
A
H
P
------
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
---
N
L
S
H
---
N
G
-----
K
--
I
-----
V
R
Q
Y
R
---
A
V
P
E
G
G
Q
K
E
R
R
L
G
A
I
C
G
---------
T
A
F
L
E
Q
A
L
A
I
----------------
E
W
------------
Q
--
H
G
-
D
--
L
T
L
--
R
G
W
--
V
A
D
P
N
H
----
T
---
T
P
A
L
A
E
I
Q
Y
C
Y
-
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
D
V
N
V
H
P
-
K
H
E
V
R
F
H
Q
S
R
L
V
H
D
F
I
Y
Q
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
83.86
28%
-91
* C3 *
3H4L
2
PMS1_YEAST
A:
[13-363]
--------------
D
V
H
R
I
T
S
G
Q
-
V
I
---
T
D
L
T
T
A
V
K
E
L
V
D
N
S
I
D
A
N
A
N
Q
I
E
I
I
F
K
D
Y
G
L
E
S
I
E
C
S
D
N
G
D
G
I
D
P
S
N
Y
E
F
L
A
L
K
H
Y
T
---------
A
---
K
V
Q
T
L
G
F
R
G
E
A
L
S
S
L
C
G
I
A
K
L
S
V
I
T
-
T
T
--
S
-
P
P
K
-
A
D
K
L
E
Y
D
-
M
--
V
G
H
---
I
-
T
S
K
T
T
T
S
R
----
N
-
K
G
T
T
V
L
V
S
Q
L
F
H
N
L
P
V
R
Q
K
-
E
F
S
K
T
F
K
R
Q
F
T
K
C
L
T
V
I
Q
G
Y
A
I
I
N
A
A
I
K
F
---
S
V
W
N
---
I
T
PK
G
K
K
N
--
L
-----
I
L
S
T
M
---
R
---
N
S
S
M
R
K
N
I
S
S
V
F
G
---------
A
G
G
M
R
G
L
E
E
V
----------------
D
L
V
L
D
LNPFKNRML---
D
Y
-
K
--
I
R
V
--
K
G
Y
--
I
S
Q
N
S
F
GC--
G
---
R
N
S
K
D
R
Q
F
-
I
Y
-
V
N
K
R
P
V
E
Y
S
T
L
L
K
C
C
N
E
V
Y
K
T
F
-
N
N
V
Q
F
P
A
V
F
L
N
L
E
L
P
M
S
L
I
D
V
N
V
T
P
D
K
R
V
I
L
L
H
N
E
R
A
V
I
D
I
F
K
T
T
L
S
D
Y
Y
N
R
Q
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.32
41%
-80
- C3 -
5AKB
-
?
C:
[40-346]
-------------------------
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
S
G
I
K
K
D
E
L
A
L
A
L
A
------
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
-
R
T
--
A
-
E
Q
Q
-
E
A
W
Q
A
Y
A
------------
V
T
V
K
P
A
A
H
----
P
-
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
---
N
L
S
H
---
N
G
-----
K
--
I
-----
V
R
Q
Y
R
---
A
VPE
G
G
Q
K
E
R
R
L
G
A
I
L
G
---------
T
A
F
L
E
Q
A
L
A
I
----------------
E
W
------------
Q
--
H
G
-
D
--
L
T
L
--
R
G
W
--
V
A
D
P
N
H
----
T
---
T
P
A
L
A
E
I
Q
-
Y
F
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
Y
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
---------------
S
R
L
V
H
D
F
I
Y
Q
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.14
41%
-84
- C3 -
5AKD
-
?
C:
[40-346]
-------------------------
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
S
G
I
K
K
D
E
L
A
L
A
L
A
------
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
-
R
T
--
A
-
E
Q
Q
-
E
A
W
Q
A
Y
A
------------
V
T
V
K
P
A
A
H
----
P
-
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
---
N
L
S
H
---
N
G
-----
K
--
I
-----
V
R
Q
Y
R
---
A
VPE
G
G
Q
K
E
R
R
L
G
A
I
L
G
---------
T
A
F
L
E
Q
A
L
A
I
----------------
E
W
------------
Q
--
H
G
-
D
--
L
T
L
--
R
G
W
--
V
A
D
P
N
H
----
T
---
T
P
A
L
A
E
I
Q
-
Y
F
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
Y
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
---------------
S
R
L
V
H
D
F
I
Y
Q
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
80.46
41%
-76
- C3 -
5AKC
-
?
C:
[40-346]
-------------------------
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
S
G
I
K
K
D
E
L
A
L
A
L
A
------
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
-
R
T
--
A
-
E
Q
Q
-
E
A
W
Q
A
Y
A
------------
V
T
V
K
P
A
A
H
----
P
-
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
---
N
L
S
H
---
N
G
-----
K
--
I
-----
V
R
Q
Y
R
---
A
VPE
G
G
Q
K
E
R
R
L
G
A
I
L
G
---------
T
A
F
L
E
Q
A
L
A
I
----------------
E
W
------------
Q
--
H
G
-
D
--
L
T
L
--
R
G
W
--
V
A
D
P
N
H
----
T
---
T
P
A
L
A
E
I
Q
-
Y
F
Y
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
Y
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
---------------
S
R
L
V
H
D
F
I
Y
Q
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
80.23
28%
-93
- C3 -
3H4L
2
PMS1_YEAST
A:
[13-363]
--------------
D
V
H
R
I
T
S
G
Q
-
V
I
---
T
D
L
T
T
A
V
K
E
L
V
D
N
S
I
D
A
N
A
N
Q
I
E
I
I
F
K
D
Y
G
L
E
S
I
E
C
S
D
N
G
D
G
I
D
P
S
N
Y
E
F
L
A
L
K
H
Y
T
---------
A
---
K
V
Q
T
L
G
F
R
G
E
A
L
S
S
L
C
G
I
A
K
L
S
V
I
T
-
T
T
--
S
-
P
P
K
-
A
D
K
L
E
Y
D
-
M
V-
G
-
H
---
I
-
T
S
K
T
T
T
S
R
----
N
-
K
G
T
T
V
L
V
S
Q
L
F
H
N
L
P
V
R
Q
K
E
F
S
K
-
T
F
K
R
Q
F
T
K
C
L
T
V
I
Q
G
Y
A
I
I
N
A
A
I
K
F
S
V
W
N
I
T
P
---
K
G
-----
K
--
K
N
L
---
I
L
S
T
M
---
R
---
N
S
S
M
R
K
N
I
S
S
V
F
G
AGGMRG
L
E
E
V
D
L
V
L
D
L
N
P
F
----------------
K
N
------------
R
ML---
D
--
Y
K
I
R
V
K
G
Y
--
I
S
Q
N
S
F
GCGR
N
---
S
K
D
R
Q
F
I
---
Y
-
V
N
K
R
P
V
E
Y
S
T
L
L
K
C
C
N
E
V
Y
K
T
F
N
N
V
-
Q
F
P
A
V
F
L
N
L
E
L
P
M
S
L
I
D
V
N
V
T
P
D
K
R
V
I
L
L
H
N
E
R
A
V
I
D
I
F
K
T
T
L
S
D
Y
Y
N
R
Q
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
79.97
32%
-96
- C3 -
1H7U
2
PMS2_HUMAN
A:
[31-351]
------------------------
V
V
---
L
S
L
S
T
A
V
K
E
L
V
E
N
S
L
D
A
G
A
T
N
I
D
L
K
L
K
D
Y
G
V
D
L
I
E
V
S
D
N
G
C
G
V
E
E
E
N
F
E
G
L
T
L
K
------------------------
G
E
A
L
S
S
L
C
A
L
S
D
V
T
I
S
T
-
C
H
--
A
-
S
A
K
V
G
T
R
L
M
F
D
H
N
--
G
-
K
---
I
-
I
-
Q
K
T
P
Y
P
----
R
P
R
G
T
T
V
S
V
Q
Q
L
F
S
T
L
P
V
R
H
K
E
F
Q
R
-
N
I
K
K
E
Y
A
K
M
V
Q
V
L
H
A
Y
C
I
I
S
A
G
I
R
V
---
S
C
T
N
Q
L
G
Q
G
-----
K
R
Q
P
-----
V
V
C
T
G
---
G
---
S
P
S
I
K
E
N
I
G
S
V
F
G
---------
Q
K
Q
L
Q
S
L
I
P
F
V
Q
L
P
PS
D
S
V
C
E
E
Y
GLS
C
S
------------
D
--
A
L
-
H
NL
F
Y
I
--
S
G
F
I
S
Q
C
T
H
G
V
----
G
---
R
S
S
T
D
R
Q
F
-
F
F
-
I
N
R
R
P
C
D
P
A
K
V
C
R
L
V
N
E
V
Y
H
-
M
Y
N
R
H
Q
Y
P
F
V
V
L
N
I
S
V
D
S
E
C
V
D
I
N
------
Q
I
L
L
Q
E
E
K
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
75.10
64%
-96
- C4 -
3GAB
-
MUTL_BACSU
A:
[435-624]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
P
I
M
Y
P
I
G
Q
M
H
G
T
Y
I
L
A
Q
N
E
N
G
L
Y
I
I
D
Q
H
A
A
Q
E
R
I
K
Y
E
Y
F
R
E
K
V
G
E
--
P
E
V
Q
E
M
I
V
P
L
T
F
H
Y
S
T
N
E
A
L
I
I
E
Q
H
K
Q
E
L
E
S
V
G
V
F
L
E
S
F
G
S
N
S
Y
I
V
R
C
H
P
A
W
F
P
K
G
E
E
A
E
L
I
E
E
I
I
Q
Q
V
L
D
S
K
N
I
D
I
K
K
L
R
E
E
A
A
I
M
M
S
C
K
-----
N
R
H
L
R
N
D
E
I
K
A
L
L
D
D
L
R
S
T
S
D
P
F
T
C
P
H
G
R
P
I
I
I
H
H
S
T
Y
E
M
E
K
M
F
K
---
9
PsiBlast_PDB
73.81
40%
-79
- C3 -
1BKN
-
MUTL_ECOLI
A:
[20-326]
-------------------------
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
------
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
-
R
T
--
A
-
E
Q
Q
-
E
A
W
Q
A
Y
A
----------
V
-
T
V
K
P
A
A
H
P
------
V
G
T
T
L
E
V
L
D
---------------
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
---
N
L
S
H
---
N
G
-----
K
--
I
-----
V
R
Q
Y
R
---
A
V
P
E
G
G
Q
K
E
R
R
L
G
A
I
C
G
---------
T
A
F
L
E
Q
A
L
A
I
----------------
E
W
------------
Q
--
H
G
-
D
--
L
T
L
--
R
G
W
--
V
A
D
P
N
H
----
T
---
T
P
A
L
A
E
I
Q
Y
C
Y
-
V
N
G
R
M
M
R
D
R
L
I
N
H
A
I
R
Q
A
C
E
D
K
L
G
A
D
Q
Q
P
A
F
V
L
Y
L
E
I
D
P
H
Q
V
---------------
S
R
L
V
H
D
F
I
Y
Q
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
72.23
64%
-94
- C4 -
3KDK
2
B:
[5-194]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
P
I
M
Y
P
I
G
Q
M
H
G
T
Y
I
L
A
Q
N
E
N
G
L
Y
I
I
D
Q
H
A
A
Q
E
R
I
K
Y
E
Y
F
R
E
K
V
G
E
V
E
P
E
V
Q
E
M
I
V
P
L
T
F
H
Y
S
T
N
E
A
L
I
I
E
Q
H
K
Q
E
L
E
S
V
G
V
F
L
E
S
F
G
S
N
S
Y
I
V
R
C
H
P
A
W
F
P
K
G
E
E
A
E
L
I
E
E
I
I
Q
Q
V
L
D
S
K
N
I
D
I
K
K
L
R
E
E
A
A
I
M
M
S
C
K
------
R
H
L
R
N
D
E
I
K
A
L
L
D
D
L
R
S
T
S
D
P
F
T
C
P
H
G
R
P
I
I
I
H
H
S
T
Y
E
M
E
K
M
F
K
---
3
PsiBlast_PDB
71.80
64%
-93
- C4 -
3KDK
2
MUTL_BACSU
A:
[4-194]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
V
P
I
M
Y
P
I
G
Q
M
H
G
T
Y
I
L
A
Q
N
E
N
G
L
Y
I
I
D
Q
H
A
A
Q
E
R
I
K
Y
E
Y
F
R
E
K
V
G
E
V
E
P
E
V
Q
E
M
I
V
P
L
T
F
H
Y
S
T
N
E
A
L
I
I
E
Q
H
K
Q
E
L
E
S
V
G
V
F
L
E
S
F
G
S
N
S
Y
I
V
R
C
H
P
A
W
F
P
K
G
E
E
A
E
L
I
E
E
I
I
Q
Q
V
L
D
S
K
N
I
D
I
K
K
L
R
E
E
A
A
I
M
M
S
C
K
------
R
H
L
R
N
D
E
I
K
A
L
L
D
D
L
R
S
T
S
D
P
F
T
C
P
H
G
R
P
I
I
I
H
H
S
T
Y
E
M
E
K
M
F
K
---
34
HHSearch
69.95
65%
-95
- C4 -
3KDG
-
MUTL_BACSU
A:
[435-627]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
P
I
M
Y
P
I
G
Q
M
H
G
T
Y
I
L
A
Q
N
E
N
G
L
Y
I
I
D
Q
H
A
A
Q
E
R
I
K
Y
E
Y
F
R
E
K
V
G
E
V
E
P
E
V
Q
E
M
I
V
P
L
T
F
H
Y
S
T
N
E
A
L
I
I
E
Q
H
K
Q
E
L
E
S
V
G
V
F
L
E
S
F
G
S
N
S
Y
I
V
R
C
H
P
A
W
F
P
K
G
E
E
A
E
L
I
E
E
I
I
Q
Q
V
L
D
S
K
N
I
D
I
K
K
L
R
E
E
A
A
I
M
M
S
C
K
G
----
N
R
H
L
R
N
D
E
I
K
A
L
L
D
D
L
R
S
T
S
D
P
F
T
C
P
H
G
R
P
I
I
I
H
H
S
T
Y
E
M
E
K
M
F
K
R
V
M
2
PsiBlast_PDB
69.95
64%
-95
- C4 -
3KDG
-
MUTL_BACSU
A:
[434-627]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
V
P
I
M
Y
P
I
G
Q
M
H
G
T
Y
I
L
A
Q
N
E
N
G
L
Y
I
I
D
Q
H
A
A
Q
E
R
I
K
Y
E
Y
F
R
E
K
V
G
E
V
E
P
E
V
Q
E
M
I
V
P
L
T
F
H
Y
S
T
N
E
A
L
I
I
E
Q
H
K
Q
E
L
E
S
V
G
V
F
L
E
S
F
G
S
N
S
Y
I
V
R
C
H
P
A
W
F
P
K
G
E
E
A
E
L
I
E
E
I
I
Q
Q
V
L
D
S
K
N
I
D
I
K
K
L
R
E
E
A
A
I
M
M
S
C
K
G
----
N
R
H
L
R
N
D
E
I
K
A
L
L
D
D
L
R
S
T
S
D
P
F
T
C
P
H
G
R
P
I
I
I
H
H
S
T
Y
E
M
E
K
M
F
K
R
V
M
52
Fugue
69.54
63%
-94
* C4 *
3KDG
-
MUTL_BACSU
A:
[433-627]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
R
V
P
I
M
Y
P
I
G
Q
M
H
G
T
Y
I
L
A
Q
N
E
N
G
L
Y
I
I
D
Q
H
A
A
Q
E
R
I
K
Y
E
Y
F
R
E
K
V
G
E
V
E
P
E
V
Q
E
M
I
V
P
L
T
F
H
Y
S
T
N
E
A
L
I
I
E
Q
H
K
Q
E
L
E
S
V
G
V
F
L
E
S
F
G
S
N
S
Y
I
V
R
C
H
P
A
W
F
P
K
G
E
E
A
E
L
I
E
E
I
I
Q
Q
V
L
D
S
K
N
I
D
I
K
K
L
R
E
E
A
A
I
M
M
S
C
K
----
G
N
R
H
L
R
N
D
E
I
K
A
L
L
D
D
L
R
S
T
S
D
P
F
T
C
P
H
G
R
P
I
I
I
H
H
S
T
Y
E
M
E
K
M
F
K
R
V
M
55
Fugue
64.42
48%
-39
- C3 -
1B63
4
MUTL_ECOLI
A:
[1-204]
SHM
P
I
Q
---
V
L
P
P
Q
L
A
N
Q
I
A
A
G
----
E
V
V
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
A
II---
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
-
R
L
T
L
T
-
S
R
T
A
E
-
Q
Q
E
-
A
W
Q
A
Y
A
E
-
G
--
R
-
D
---
M
-
N
V
-
T
-
V
K
P
A
A
H
P
--
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
-R
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
---
N
L
S
H
---
N
G
-----
K
--
I
-----
V
R
Q
Y
R
---
A
---
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
63.55
45%
-55
- C3 -
1B63
4
MUTL_ECOLI
A:
[3-218]
-----
M
P
I
Q
V
L
P
P
Q
L
A
N
Q
I
A
A
G
E
-
V
V
---
E
R
P
A
S
V
V
K
E
L
V
E
N
S
L
D
A
G
A
T
R
I
D
I
D
I
E
R
G
G
A
K
L
I
R
I
R
D
N
G
C
G
I
K
K
D
E
L
A
L
A
L
A
R
H
A
T
S
K
I
A
S
L
D
D
L
E
---
A
I
I
S
L
G
F
R
G
E
A
L
A
S
I
S
S
V
S
R
L
T
L
T
S
R
T
A
--
E
-
Q
Q
E
-
A
W
Q
A
Y
A
E
-
G
--
R
-
D
M--
N
-
V
T
V
K
P
A
A
H
----
P
-
V
G
T
T
L
E
V
L
D
L
F
Y
N
T
P
A
R
R
K
-
F
L
R
-
T
E
K
T
E
F
N
H
I
D
E
I
I
R
R
I
A
L
A
R
F
D
V
T
I
---
N
L
S
H
---
N
G
-----
K
--
I
-----
V
R
Q
Y
R
---
A
---
V
P
E
G
G
Q
K
E
R
R
L
G
A
---------
I
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------