@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1565: (2016-03-26 )
VNKLVLIDGNSIANRAFYALPLLNNDKGVYTNAVYGFAMMLMNVLEKEKPSHVLVAFDAGKTTFRHTTFKGYKGGRQKTPSELSEQFPFIRELLTAYDIPQYELANYEADDIIGTLTKKAEADGMEVAIITGDRDLTQLASEKTTVYITKKGIADMETNTPETLKEKYNLTPEQIIDMKGLMGDSSDNIPGIPGVGEKTALKLLHEFGGTVESVLEHAEEISGKKLKEKVLENKELAILSKELATINVDSPIECTVESTKYDGYQTEKVIPLLKEMNFTTLLKNIEGDTPEESKELKELSFEIVTELKEQHFGGKTALYVELENDNYHTANFIGLTVHSSQGTYFFTKETAESSEAFRKWVESDQTKVVYDAKKTIVAMNRIGLAISGITFDIMLASYLLNPSDSIDDFTSVAVRHDYTEVETDEAVYGKGAKRSTPEESIVAAHLARKAVAIADLEKRLVDDLEKNEQLALMEDLELPLTFVLAEMEMQGVSVDTDRLEDMKVELGGRLKTLEASIHSLAGEEFNINSPKQLGVILFEKLELPPVKKTKTGYSTAADVLESLSGKHAIIDEILLYRQLGKIQSTYIEGLLKVTDKETHKVHTRFNQTLTQTGRLSSVDPNLQNIPIRLEEGRKIRQVFVPSKPGWKMFSADYSQVELRVLAHISEDENLIYAFKHDYDIHTKTAMDVFHVEKEEVDSLMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAKDFIDRYFVSYPAVKEYMQDIVRFAKEKGYVETILHRRRYIPEIVSRNFNVRGFAERTAMNTPIQGSAADIIKKAMILMSERLVSEKLEAKLLLQVHDELIFEAPEAEIAKLEEIVPDVMENAVELSVPLKVDSAFGDTWYDAK
Atome Classification :
(93 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.....--..370........380.......390.......400..---.....410.......420---.......430.......440.......450.......460.......470........480.......490.......500.......510.......520.......530.......540.......-550-.......560.......570.......580.......590.......600...---....610.......620...---....630.------.....----.640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810...-.--------...820..-----------.....830.......840.......850..-------.....860.......870...----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
V
N
K
L
V
L
IDGNSIANR
A
F
Y
A
LPLLNNDKGV
Y
T
N
A
V
Y
G
F
A
M
M
L
M
N
V
L
E
KEKPS
H
V
L
V
A
FDAGK
T
T
F
R
HTTFKGYKGGRQK
T
P
S
E
L
S
E
Q
F
P
F
I
R
E
L
L
T
AYDIP
Q
Y
E
LANY
E
A
D
D
I
I
G
T
L
T
K
KAEADG
M
E
V
A
I
I
TGD
R
D
L
T
Q
LASEK
T
T
V
Y
I
TKKGIADMETN
T
P
E
T
L
K
E
K
YNL
T
P
E
Q
I
I
D
M
K
GLMGDSSDNIPGIPGV
G
E
K
T
A
L
K
L
L
H
E
FG
G
T
V
E
S
V
L
E
H
A
E
E
IS
G
K
K
L
K
E
K
V
LENK
E
L
A
I
L
S
K
E
L
A
T
I
NVDS
P
I
E
C
T
V
ESTKYDGY
Q
T
E
K
V
I
P
L
L
K
EM
N
F
T
T
L
L
K
NIEGDT
P
E
E
S
K
E
L
K
E
L
S
F
E
I
V
T
E
L
K
E
QHFGG
K
T
A
L
Y
V
E
LENDNY
H
T
A
N
F
I
G
L
T
V
HSSQ
G
T
Y
F
F
TKETA
E
S
S
E
A
F
R
K
W
V
ESDQ
T
K
--
V
V
Y
D-A
K
K
T
I
V
A
MNRI
G
L
A
ISG
I
T
F
D
I
M
L
A
S
Y
LLNPSD---SI
D
D
F
T
S
V
A
V
RHDYTEVE---TDEAVYGKGAKRSTP
E
E
S
I
V
A
A
H
L
A
R
K
A
V
A
I
A
D
L
E
K
R
L
V
D
D
L
EKNE
Q
L
-
A
L
M
E
DLEL
P
L
T
F
V
L
A
E
M
EMQGVSV
D
T
D
R
L
E
D
M
K
V
E
LGGR
L
K
T
L
E
A
S
I
H
S
LAGEEFNIN
S
P
K
Q
L
G
V
I
L
F
E
KLELPPVKKT-KTG-YS
T
A
A
D
V
L
E
S
LSG
K
H
A
I
I
D
E
I
L
L
Y
R
Q
L
G
K
I
Q
S
T
Y
I
E
G
L
L
K
VTDKE
T
H
K
V
H
T
R
F
---
N
Q
T
L
TQTGRLSSVDPNLQNI---
P
I
R
LEEG
R
------
K
I
R
Q
V
----FVPSKPG
W
K
M
FSAD
Y
S
Q
V
E
L
R
V
L
A
HISEDE
N
L
I
Y
A
F
KHDYDIHT
K
T
A
M
D
V
F
HV
E
K
E
E
V
D
S
L
M
R
R
Q
A
KAV
N
F
G
I
V
Y
GISDYGLSQNLGI
T
R
K
E
A
K
D
F
I
D
R
Y
F
VS
Y
P
A
V
K
E
Y
M
Q
D
I
V
R
F
A
K
EK
G
Y
V
E
T
I
L
H
R
R
R
Y
I
P
E
I
V
SRNFNV
R
G
F
AERTAMNTPIQG
S
A
A
D
I
I
K
K
A
M
I
L
M
S
E
R
L
V
-
S
--------
E
K
L
E
A
K
L
L
-----------
L
Q
V
H
D
E
L
IFEAP
E
A
E
I
A
K
L
E
E
I
V
P
D
V
M
ENA-------
V
E
L
S
V
P
L
K
V
DSAFGDTWYDAK----
93
PsiBlast_CBE
95.74
61%
-93
- C4 -
3HT3
5
?
A:
[1-579]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
P
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
92
PsiBlast_CBE
95.56
61%
-92
- C4 -
3HT3
8
?
D:
[1-579]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
P
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
75
PsiBlast_CBE
95.56
61%
-94
- C4 -
1L5U
8
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
10
PsiBlast_PDB
95.52
61%
-96
- C4 -
2XY6
6
?
A:
[3-581]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
R
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
62
PsiBlast_CBE
95.45
61%
-92
- C4 -
1NKC
7
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
46
PsiBlast_CBE
95.39
61%
-94
- C4 -
1U4B
8
DPO1_GEOSE
A:
[3-580]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
18
PsiBlast_PDB
95.38
61%
-95
- C4 -
4UQG
7
?
A:
[1-579]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
R
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
63
PsiBlast_CBE
95.37
61%
-94
- C4 -
1NKB
8
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
3
PsiBlast_PDB
95.36
61%
-93
- C4 -
2HHT
10
?
A:
[1-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
71
PsiBlast_CBE
95.35
61%
-93
- C4 -
1NJZ
9
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
61
PsiBlast_CBE
95.30
61%
-94
- C4 -
1NKE
11
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
5
PsiBlast_PDB
95.30
61%
-93
- C4 -
2HHV
10
?
A:
[1-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
79
PsiBlast_CBE
95.29
61%
-93
- C4 -
1L3S
10
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
90
PsiBlast_CBE
95.27
61%
-95
- C4 -
2Y1J
4
?
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
S
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
K
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
R
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
14
PsiBlast_PDB
95.28
61%
-93
- C4 -
4B9S
9
?
A:
[41-619]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
R
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
76
PsiBlast_CBE
95.26
61%
-94
- C4 -
1L3V
8
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
7
PsiBlast_PDB
95.26
61%
-95
- C4 -
2HW3
10
?
A:
[1-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
84
PsiBlast_CBE
95.19
61%
-92
- C4 -
4BDP
6
DPO1_GEOSE
A:
[3-580]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
R
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
40
PsiBlast_CBE
95.16
60%
-94
- C4 -
4DQR
7
?
D:
[14-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
A
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
68
PsiBlast_CBE
95.15
61%
-93
- C4 -
1NK5
7
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
50
PsiBlast_CBE
95.12
61%
-94
- C4 -
1U45
7
DPO1_GEOSE
A:
[3-580]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
72
PsiBlast_CBE
95.08
61%
-94
- C4 -
1NJY
8
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
64
PsiBlast_CBE
94.99
61%
-93
- C4 -
1NK9
8
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
53
PsiBlast_CBE
94.98
61%
-93
- C4 -
3EZ5
8
DPO1_GEOSE
D:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
31
PsiBlast_CBE
94.98
60%
-94
- C4 -
4EZ6
4
?
D:
[13-592]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
16
PsiBlast_PDB
94.97
61%
-94
- C4 -
4B9U
8
?
A:
[41-619]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
R
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
85
PsiBlast_CBE
94.95
61%
-93
- C4 -
3BDP
5
DPO1_GEOSE
A:
[3-580]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
R
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
51
PsiBlast_CBE
94.95
61%
-95
- C4 -
4DWI
12
?
A:
[3-581]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
48
PsiBlast_CBE
94.94
61%
-93
- C4 -
1U48
7
DPO1_GEOSE
A:
[3-580]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
78
PsiBlast_CBE
94.91
61%
-93
- C4 -
1L3T
8
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
29
PsiBlast_CBE
94.87
60%
-95
- C4 -
4F2R
8
?
D:
[10-592]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
L
A
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
86
PsiBlast_CBE
94.80
61%
-94
- C4 -
2BDP
6
DPO1_GEOSE
A:
[3-580]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
R
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
42
PsiBlast_CBE
94.81
61%
-94
- C4 -
1LV5
6
DPO1_GEOSE
B:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
A
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
47
PsiBlast_CBE
94.80
61%
-92
- C4 -
1U49
7
DPO1_GEOSE
A:
[3-580]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
28
PsiBlast_CBE
94.80
60%
-94
- C4 -
4F2S
6
?
D:
[10-592]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
L
A
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
15
PsiBlast_PDB
94.80
61%
-94
- C4 -
4B9T
5
?
A:
[41-619]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
R
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
77
PsiBlast_CBE
94.77
61%
-92
- C4 -
1L3U
8
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
66
PsiBlast_CBE
94.71
61%
-92
- C4 -
1NK7
9
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
49
PsiBlast_CBE
94.70
61%
-92
- C4 -
1U47
7
DPO1_GEOSE
A:
[3-580]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
44
PsiBlast_CBE
94.70
61%
-93
- C4 -
1UA1
6
DPO1_GEOSE
A:
[3-580]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
23
PsiBlast_CBE
94.69
60%
-95
- C4 -
4DQP
6
?
D:
[14-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
17
PsiBlast_PDB
94.68
61%
-93
- C4 -
4B9V
9
?
A:
[41-619]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
R
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
52
PsiBlast_CBE
94.64
61%
-93
- C4 -
4DSI
11
?
A:
[3-581]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
81
PsiBlast_CBE
94.54
61%
-97
- C4 -
4DSK
6
?
A:
[1-579]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
-----
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
65
PsiBlast_CBE
94.52
61%
-92
- C4 -
1NK8
9
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
54
PsiBlast_CBE
94.51
61%
-92
- C4 -
3EZ5
8
DPO1_GEOSE
A:
[1-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
67
PsiBlast_CBE
94.50
61%
-91
- C4 -
1NK6
7
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
24
PsiBlast_CBE
94.50
60%
-92
- C4 -
4DQI
5
?
D:
[14-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
19
PsiBlast_PDB
94.48
61%
-92
- C4 -
1LV5
7
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
A
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
41
PsiBlast_CBE
94.46
60%
-94
- C4 -
4DQQ
7
?
D:
[9-592]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
P
L
A
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
A
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
80
PsiBlast_CBE
94.45
61%
-92
- C4 -
4DSL
4
?
A:
[1-579]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
37
PsiBlast_CBE
94.39
60%
-94
- C4 -
3PX4
6
?
D:
[14-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
43
PsiBlast_CBE
94.38
61%
-94
- C4 -
4O0I
11
?
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
56
PsiBlast_CBE
94.37
61%
-91
- C4 -
2HVI
6
?
A:
[1-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
45
PsiBlast_CBE
94.34
61%
-93
- C4 -
1UA0
6
?
A:
[3-580]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
89
PsiBlast_CBE
94.33
61%
-91
- C4 -
2HHW
7
?
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
26
PsiBlast_CBE
94.32
60%
-92
- C4 -
4F4K
7
?
D:
[14-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
20
PsiBlast_PDB
94.31
61%
-93
- C4 -
2XO7
6
?
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
R
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
91
PsiBlast_CBE
94.30
61%
-94
* C4 *
2Y1I
4
?
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
S
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
K
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
R
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
87
PsiBlast_CBE
94.28
61%
-93
- C4 -
3EYZ
6
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
58
PsiBlast_CBE
94.29
61%
-96
- C4 -
2HVH
8
?
A:
[1-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
34
PsiBlast_CBE
94.28
60%
-91
- C4 -
3TI0
5
?
D:
[14-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
32
PsiBlast_CBE
94.28
60%
-93
- C4 -
4DSF
7
?
D:
[14-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
69
PsiBlast_CBE
94.19
61%
-91
- C4 -
1NK4
8
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
30
PsiBlast_CBE
94.17
60%
-93
- C4 -
4EZ9
4
?
D:
[14-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
38
PsiBlast_CBE
94.16
60%
-93
- C4 -
3PX0
6
?
D:
[14-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
74
PsiBlast_CBE
94.14
61%
-90
- C4 -
1NJW
8
?
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
27
PsiBlast_CBE
94.13
60%
-94
- C4 -
4F3O
6
?
D:
[14-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
13
PsiBlast_PDB
94.13
61%
-91
- C4 -
4B9N
9
?
A:
[41-619]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
A
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
E
E
L
A
E
Q
L
R
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
S
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
R
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
39
PsiBlast_CBE
94.11
60%
-91
- C4 -
3PV8
6
?
D:
[14-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
35
PsiBlast_CBE
94.08
60%
-91
- C4 -
3THV
6
?
D:
[14-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
60
PsiBlast_CBE
94.04
61%
-91
- C4 -
1XC9
9
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
36
PsiBlast_CBE
94.04
60%
-92
- C4 -
3PX6
6
?
D:
[12-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
70
PsiBlast_CBE
93.99
61%
-91
- C4 -
1NK0
8
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
73
PsiBlast_CBE
93.98
61%
-90
- C4 -
1NJX
9
DPO1_GEOSE
A:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
33
PsiBlast_CBE
93.85
60%
-93
- C4 -
4DSE
7
?
D:
[14-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
57
PsiBlast_CBE
93.84
61%
-93
- C4 -
2HVH
8
?
D:
[1-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
55
PsiBlast_CBE
93.76
61%
-90
- C4 -
2HVI
6
?
D:
[1-580]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
88
PsiBlast_CBE
93.62
61%
-92
- C4 -
2HHW
6
?
D:
[2-580]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
83
PsiBlast_CBE
93.48
61%
-93
- C4 -
4DSJ
4
?
A:
[1-579]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
21
PsiBlast_CBE
93.13
60%
-93
- C4 -
4DS5
5
?
D:
[12-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
--------------------
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
82
PsiBlast_CBE
92.62
61%
-94
- C4 -
4DSJ
2
?
B:
[1-579]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
K
K
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
-----
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
D
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
A
M
D
I
F
Q
V
S
E
D
E
V
T
P
N
M
R
R
Q
A
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
22
PsiBlast_CBE
92.31
60%
-93
- C4 -
4DS4
5
?
D:
[12-592]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
H
T
K
T
--------------------
K
A
V
N
F
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
25
PsiBlast_CBE
92.06
60%
-94
- C4 -
4F8R
4
?
D:
[14-592]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
A
F
T
L
A
D
R
V
T
E
E
M
L
A
D
K
A
A
L
V
V
E
V
V
E
E
N
Y
H
D
A
P
I
V
G
I
A
V
V
N
E
H
G
R
F
F
L
R
P
E
T
A
L
A
D
P
Q
F
V
A
W
L
-
G
D
E
T
K
KK
S
M
F
D
-
S
K
R
A
A
V
A
L
K
W
K
G
I
E
L
C
G
V
S
F
D
L
L
L
A
A
Y
L
L
D
P
A
Q
---
G
V
D
D
V
A
A
A
A
K
M
K
Q
Y
E
A
V
R
---
P
D
E
A
V
Y
G
K
G
A
K
R
A
V
P
D
E
P
V
L
A
E
H
L
V
R
K
A
A
A
I
W
E
L
E
R
P
F
L
D
E
L
R
R
N
E
Q
D
-
R
L
L
V
E
L
E
Q
P
L
S
S
I
L
A
E
M
E
F
A
G
V
K
V
D
T
K
R
L
E
Q
M
G
K
E
L
A
E
Q
L
G
T
V
E
Q
R
I
Y
E
L
A
G
Q
E
F
N
I
N
S
P
K
Q
L
G
V
I
L
F
E
K
L
Q
L
P
V
L
K
K
T
-
K
T
G
-
Y
S
T
S
A
D
V
L
E
K
L
A
P
Y
H
E
I
V
E
N
I
L
H
Y
R
Q
L
G
K
L
Q
S
T
Y
I
E
G
L
L
K
V
V
R
P
A
T
K
K
V
H
T
I
F
---
N
Q
A
L
T
Q
T
G
R
L
S
S
T
E
P
N
L
Q
N
I
---
P
I
R
L
E
E
G
R
------
K
I
R
Q
A
----
F
V
P
S
E
S
D
W
L
I
F
A
A
D
Y
S
Q
I
E
L
R
V
L
A
H
I
A
E
D
D
N
L
M
E
A
F
R
R
D
L
D
I
--------------------------
V
N
Y
G
I
V
Y
G
I
S
D
Y
G
L
A
Q
N
L
N
I
S
R
K
E
A
A
E
F
I
E
R
Y
F
E
S
F
P
G
V
K
R
Y
M
E
N
I
V
Q
E
A
K
Q
K
G
Y
V
T
T
L
L
H
R
R
R
Y
L
P
D
I
T
S
R
N
F
N
V
R
S
F
A
E
R
M
A
M
N
T
P
I
Q
G
S
A
A
D
I
I
K
K
A
M
I
D
L
N
A
R
L
K
-
E
--------
E
R
L
Q
A
H
L
L
-----------
L
Q
V
H
D
E
L
I
L
E
A
P
K
E
E
M
E
R
L
C
R
L
V
P
E
V
M
E
Q
A
-------
V
T
L
R
V
P
L
K
V
D
Y
H
Y
G
S
T
W
Y
D
A
K
----
105
Fugue
73.15
30%
-67
- C4 -
4X0Q
7
DPOLQ_HUMAN
A:
[6-772]
--
S
L
S
I
I
D
----------------------------------------------------------------------
V
A
S
D
Q
N
L
F
Q
T
F
I
K
E
W
R
C
---------------------------------------------
K
K
R
F
S
I
S
L
A
C
E
K
I
R
D
------------------------------
D
T
L
V
V
G
--------------------------------------------
L
A
V
C
------------------------------------------------------------------------
W
G
G
R
D
A
Y
Y
F
S
L
L
D
P
S
L
T
-----------------
L
K
D
R
M
W
Y
L
Q
S
C
L
R
K
E
S
D
K
E
C
S
V
--
V
I
Y
D
F
I
Q
S
Y
K
I
L
L
L
S
C
G
I
S
L
E
Q
S
Y
E
D
P
K
V
A
C
W
L
L
D
P
D
S
QEP
T
L
H
S
I
V
T
S
F
L
P
H
E
L
P
L
L
E
GME
T
S
Q
G
I
Q
S
L
G
L
N
A
G
S
E
H
S
G
--
R
Y
R
A
S
V
E
S
I
L
I
F
N
S
M
N
Q
L
N
S
L
L
Q
K
E
N
L
Q
-
D
V
F
R
K
V
E
M
P
S
Q
Y
C
L
A
L
L
E
L
N
G
I
G
F
S
T
A
E
C
E
S
Q
K
H
I
M
Q
A
K
L
D
A
I
E
T
Q
A
Y
Q
L
A
G
H
S
F
S
F
T
S
S
D
D
I
A
E
V
L
F
L
E
L
K
L
P
P
-------
Q
-
F
S
T
S
K
D
V
L
N
K
L
K
A
L
H
P
L
P
G
L
I
L
E
W
R
R
I
T
N
A
I
T
K
V
V
F
P
L
Q
R
E
K
C
L
N
P
F
L
G
M
E
R
I
Y
P
V
S
Q
S
H
T
A
T
G
R
I
T
F
T
E
P
N
I
Q
N
V
---
P
R
D
F
E
I
K
M
G
M
P
F
S
I
S
M
R
H
A
----
F
V
P
F
-
P
G
G
S
I
L
A
A
D
Y
S
Q
L
E
L
R
I
L
A
H
L
S
H
D
R
R
L
I
Q
V
L
N
T
G
A
D
V
F
R
S
I
A
A
E
W
K
M
I
E
P
E
S
V
G
D
D
L
R
Q
Q
A
K
Q
I
C
Y
G
I
I
Y
G
M
G
A
K
S
L
G
E
Q
M
G
I
K
E
N
D
A
A
C
Y
I
D
S
F
K
S
R
Y
T
G
I
N
Q
F
M
T
E
T
V
K
N
C
K
R
D
G
F
V
Q
T
I
L
G
R
R
R
Y
L
P
G
I
K
D
N
N
P
Y
R
K
A
H
A
E
R
Q
A
I
N
T
I
V
Q
G
S
A
A
D
I
V
K
I
A
T
V
N
I
Q
K
Q
L
E
-
T
F
H
STFKS
H
G
H
R
E
G
M
L
Q
S
DC
P
I
R
G
G
F
F
I
L
Q
L
H
D
E
L
L
Y
E
V
A
E
E
D
V
V
Q
V
A
Q
I
V
K
N
E
M
E
S
A
-------
V
K
L
S
V
K
L
K
V
K
V
K
I
G
A
S
W
G
E
L
K
D
F
D
V
104
Fugue
72.90
31%
-65
- C4 -
4XVK
4
DPOLN_HUMAN
A:
[1-666]
-----------------------------------------------------------------------------------
K
K
H
F
C
D
I
R
H
L
-----------
D
D
W
A
K
S
Q
L
I
E
M
L
K
Q
---
A
A
A
L
V
I
T
V
M
Y
T
D
G
S
-
T
Q
L
G
A
D
Q
T
P
V
S
-
S
V
R
G
I
V
V
L
V
K
R
Q
A
C
G
P
V
L
E
G
F
V
S
D
D
P
C
I
Y
I
Q
I
E
H
S
A
I
W
D
--------------------------------------
Q
E
Q
E
A
H
Q
Q
F
A
R
N
V
L
F
Q
T
M
K
C
--------------------
K
C
P
V
I
C
F
----------------------
N
A
K
D
F
V
R
I
V
L
Q
F
F
G
N
D
-------------
G
S
W
K
H
V
A
D
F
I
G
L
-----------------------------------------------------------
D
P
R
I
A
A
W
L
I
D
P
S
D
---
A
T
P
S
F
E
D
L
V
E
K
Y
----
C
E
---
K
S
I
T
V
K
V
N
S
T
Y
G
N
S
S
-
R
N
I
V
N
Q
N
V
R
E
N
L
K
T
L
Y
R
L
T
M
D
L
C
S
K
L
K
D
Y
G
L
W
-
Q
L
F
R
T
L
E
L
P
L
I
P
I
L
A
V
M
E
S
H
A
I
Q
V
N
K
E
E
M
E
K
T
S
A
L
L
G
A
R
L
K
E
L
E
Q
E
A
H
F
V
A
G
E
R
F
L
I
T
S
N
N
Q
L
R
E
I
L
F
G
K
L
K
L
H
L
L
S
Y
P
------
S
T
S
E
A
V
L
N
A
L
R
D
L
H
P
L
P
K
I
I
L
E
Y
R
Q
V
H
K
I
K
S
T
F
V
D
G
L
L
A
C
M
K
K
G
--
S
I
S
S
T
W
---
N
Q
T
G
T
V
T
G
R
L
S
A
K
H
P
N
I
Q
G
I
SK
H
P
I
Q
I
T
T
P
K
------
K
I
L
T
I
S
PRA
M
F
V
S
S
K
G
H
T
F
L
A
A
D
F
S
Q
I
E
L
R
I
L
T
H
L
S
G
D
P
E
L
L
K
L
----
D
D
V
F
S
T
L
T
S
Q
W
K
D
V
P
V
E
Q
V
T
H
A
D
R
E
Q
T
K
K
V
V
Y
A
V
V
Y
G
A
G
K
E
R
L
A
A
C
L
G
V
P
I
Q
E
A
A
Q
F
L
E
S
F
L
Q
K
Y
K
K
I
K
D
F
A
R
A
A
I
A
Q
C
H
Q
T
G
C
V
V
S
I
M
G
R
R
R
P
L
P
R
I
H
A
H
D
Q
Q
L
R
A
Q
A
E
R
Q
A
V
N
F
V
V
Q
G
S
A
A
D
L
C
K
L
A
M
I
H
V
F
T
A
V
A
A
S
--------
H
T
L
T
A
R
L
V
-----------
A
Q
I
H
D
E
L
L
F
E
V
E
D
P
Q
I
P
E
C
A
A
L
V
R
R
T
M
E
S
L
EQVQALE
L
Q
L
Q
V
P
L
K
V
S
L
S
A
G
R
S
W
G
H
L
V
PLQ-
94
PsiBlast_CBE
72.88
44%
-80
- C4 -
4XIU
3
DPO1_THEAQ
A:
[79-538]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
L
L
A
Y
L
L
D
P
S
N
---
T
----
T
P
E
G
V
A
R
R
Y
G
G
E
W
---
T
E
E
A
-----
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
---------------
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
---
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
---
P
V
R
T
P
L
G
Q
------
R
I
R
R
A
----
F
I
-
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
L
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
-----------
E
E
M
G
A
R
M
L
-----------
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
-------
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
97
PsiBlast_CBE
72.64
44%
-80
- C4 -
4N5S
12
DPO1_THEAQ
A:
[93-552]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
L
L
A
Y
L
L
D
P
S
N
---
T
----
T
P
E
G
V
A
R
R
Y
G
G
E
W
---
T
E
E
A
-----
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
---------------
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
---
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
---
P
V
R
T
P
L
G
Q
------
R
I
R
R
A
----
F
I
-
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
L
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
-----------
E
E
M
G
A
R
M
L
-----------
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
-------
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
99
PsiBlast_CBE
71.91
44%
-79
- C4 -
4KTQ
2
DPO1_THEAQ
A:
[79-538]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
L
L
A
Y
L
L
D
P
S
N
---
T
----
T
P
E
G
V
A
R
R
Y
G
G
E
W
---
T
E
E
A
-----
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
---------------
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
---
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
---
P
V
R
T
P
L
G
Q
------
R
I
R
R
A
----
F
I
-
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
-----------
E
E
M
G
A
R
M
L
-----------
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
-------
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
100
PsiBlast_CBE
71.34
44%
-82
- C4 -
1QSY
5
DPO1_THEAQ
A:
[80-539]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
L
L
A
Y
L
L
D
P
S
N
---
T
----
T
P
E
G
V
A
R
R
Y
G
G
E
W
---
T
E
E
A
-----
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
---------------
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
---
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
---
P
V
R
T
P
L
G
Q
------
R
I
R
R
A
----
F
I
-
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
-----------
E
E
M
G
A
R
M
L
-----------
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
-------
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
95
PsiBlast_CBE
70.39
44%
-80
- C4 -
2KTQ
4
DPO1_THEAQ
A:
[78-537]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
L
L
A
Y
L
L
D
P
S
N
---
T
----
T
P
E
G
V
A
R
R
Y
G
G
E
W
---
T
E
E
A
-----
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
---------------
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
---
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
---
P
V
R
T
P
L
G
Q
------
R
I
R
R
A
----
F
I
-
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
----------
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
-----------
E
E
M
G
A
R
M
L
-----------
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
-------
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
96
PsiBlast_CBE
69.64
44%
-80
- C4 -
5KTQ
1
DPO1_THEAQ
A:
[83-542]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
L
L
A
Y
L
L
D
P
S
N
---
T
----
T
P
E
G
V
A
R
R
Y
G
G
E
W
---
T
E
E
A
-----
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
---------------
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
---------
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
---
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
---
P
V
R
T
P
L
G
Q
------
R
I
R
R
A
----
F
I
-
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
S
W
M
F
G
V
P
R
E
A
V
D
P
L
M
R
R
A
A
K
T
I
N
F
G
V
L
Y
G
M
S
A
H
R
L
S
Q
E
L
A
I
P
Y
E
E
A
Q
A
F
I
E
R
Y
F
Q
S
F
P
K
V
R
A
W
I
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
-----------
E
E
M
G
A
R
M
L
-----------
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
-------
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----
98
PsiBlast_CBE
68.36
44%
-86
- C4 -
4N56
4
DPO1_THEAQ
A:
[93-552]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
M
L
L
A
Y
L
L
D
P
S
N
---
T
----
T
P
E
G
V
A
R
R
Y
G
G
E
W
---
T
E
E
A
-----
G
E
R
A
A
L
S
E
R
L
F
A
N
L
W
G
R
---------------
L
E
G
E
E
R
L
L
W
L
Y
R
E
V
E
R
P
L
S
A
V
L
A
H
M
E
A
T
G
V
R
L
D
V
A
Y
L
R
A
L
S
L
E
V
A
E
E
I
A
R
L
E
A
E
V
F
R
L
A
G
H
P
F
N
L
N
S
R
D
Q
L
E
R
V
L
F
D
E
L
G
L
P
A
I
G
K
T
E
K
T
G
K
R
S
T
S
A
A
V
L
E
A
L
R
E
A
H
P
I
V
E
K
I
L
Q
Y
R
E
L
T
K
L
K
S
T
Y
I
D
P
L
P
D
L
I
H
P
R
T
G
R
L
H
T
R
F
---
N
Q
T
A
T
A
T
G
R
L
S
S
S
D
P
N
L
Q
N
I
---
P
V
R
T
P
L
G
Q
------
R
I
R
R
A
----
F
I
-
A
E
E
G
W
L
L
V
A
L
D
Y
S
Q
I
E
L
R
V
L
A
H
L
S
G
D
E
N
L
I
R
V
F
Q
E
G
R
D
I
H
T
E
T
A
------------------
A
K
T
I
N
F
G
V
L
Y
G
---------------------------
F
P
K
V
R
A
W
L
E
K
T
L
E
E
G
R
R
R
G
Y
V
E
T
L
F
G
R
R
R
Y
V
P
D
L
E
A
R
V
K
S
V
R
E
A
A
E
R
M
A
F
N
M
P
V
Q
G
T
A
A
D
L
M
K
L
A
M
V
K
L
F
P
R
L
-----------
E
E
M
G
A
R
M
L
-----------
L
Q
V
H
D
E
L
V
L
E
A
P
K
E
R
A
E
A
V
A
R
L
A
K
E
V
M
E
G
V
-------
Y
P
L
A
V
P
L
E
V
E
V
G
I
G
E
D
W
L
S
A
K
----