@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1804: (2016-03-28 )
MLLKRLEMNGFKSFADKVAIDFVPGMTAVVGPNGSGKSNITEAIRWVLGEQSAKSLRGGRMGDVIFAGSDTRKPINFAEVSLILENEDHFLPLDYSEVAVTRRIYRNGDSEFLINKENCRLKDIVDLFMDSGLGRESFSIISQGKIDEILNSKPEERRSIFEEAAGVLKYKHRKKQAENKLFETEENLNRVQDILYELEGQLEPLEMQASIAKDYLFQQEELEKYEVTLLASEISSLTEKLAEVRKEFGENQTVLIKLREELHAEEAVISREKQALNETDIALDKLQERLLVETEKLEQLEGERNLQLERKKHSSENEQVYAETLAVITEKITALEEQKEVLSSSKLEKETALEIAIKSKKVLEATLAKYDDLSEEAIENRKSDYIDLRHTQTTINNDLGYIERQIGQITSRIDKLDLENSHHVDDRKDMLAQIETTKTHLTKIQSELTEQMEIYREVQQTLAKQEAVFGTQERALYKHYETVQQMKSRKETLEELADDYAGFFQGVREVLKAKKEIPGILGALVELVEIPAKYQQAMETALGASAQNVVVEDDRVAREAISFLKKTKSGRATFLPLSTIQPRELPAATKNALSNQPAFIALASEVISFDEKVSPVILNALGTTILAKDLKGANTLARLVNFRYRIVTLEGDVVNAGGSMTGGATKGGKSSILTRKHELGQLAEKIAELNESTREMESAVQLAKDSMAKKREELEETRVIGENLRLQEKELLGKLDRETENLERFNKQLQLYDIEKADGSEELNKLLERKETLLQEQVEIAKQIEVTDEEIKAMTSSSKALESKRAADLESLSSLKAQIAAKREQLQSATEAVERVTTTLHENYEQKEAAEQKLASLKTNLTSVHTSEETARKSIEELRKDKTETSEKLTQTRQTRAELQEKLELLEAELTQKNNQISFYMEQKNNAEISIGRLEVDIANRIDRLQEAYLLTPEQAEEKILSEVNTEQARSKVRLLKRSIDELGIVNIGAIEEFERIQERFDFLTGQQADLLAAKETLFKVMDEMDEEMKIRFSESFEAIKTEFAIVFPELFGGGSAELVLLDPENLLTTGIDIVVQPPGKKLQNLSLRSGGERALTAIALLFAIIRVRPVPFCILDEVEAALDEANVTRFSRYLKQFESGTQFIVITHRKGTMEEADVLYGVTMQESGVSKLVSVRLEETAELIK
Atome Classification :
(20 SA)
-------.........10......-.-.20....-....30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.....-..210.......220...-....230.......240.......250.......260.......270.......280.......--290.......300--.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590........600.......610........620.......630.......640.......650.......660.......670.......680.....----...690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870...-....880.......890.......900.......910.......920.......930.......940---........950.......960....----...970.......980.......990.......1000......1010......1020......1030......1040......1050......1060.......1070......1080......--1090......1100......1110......1120......1130......1140......1150......1160......1170......1180...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------ML
L
K
RLEMN
G
F
K
S
F
A
D
K
-
V
-
A
I
DFVPG-M
T
A
V
VGPNGSG
K
S
N
I
T
E
A
I
R
W
V
LGEQ
S
A
K
S
LRGGRMG
D
V
I
F
AGSDTRKPI
N
F
A
E
V
S
L
I
L
ENED
H
F
LPL
D
Y
S
E
V
A
V
T
R
R
I
Y
RNGDS
E
F
L
I
NKENC
R
L
K
D
I
V
D
L
F
M
DSGLGR
E
S
F
S
I
ISQG
K
I
D
E
I
L
NSK
P
E
E
R
R
S
I
F
E
E
A
A
G
V
L
K
Y
K
H
R
K
K
Q
A
ENKLFE
T
E
E
N
L
N
R
V
Q
D
I
L
Y
E
LEGQLE
P
L
E
M
-
Q
A
S
I
A
K
D
Y
L
F
Q
Q
E
E
L
E
K
Y
-
E
V
T
L
L
A
S
E
I
S
S
L
T
E
K
L
A
E
V
R
K
E
FGEN
Q
T
V
L
I
K
L
R
E
E
LH
A
E
E
A
V
I
S
R
E
K
Q
ALNET
D
I
A
L
D
K
L
Q
E
R
--
L
L
V
E
T
E
K
L
E
Q
L
EG--ERN
L
Q
L
E
R
KKHSSE
N
E
Q
V
Y
A
E
T
L
A
V
I
T
E
K
I
T
A
L
E
E
Q
K
E
V
L
S
S
SKLEKE
T
A
L
E
I
A
IKS
K
K
V
L
E
A
T
L
A
KYDD
L
S
E
E
A
I
E
NRKSD
Y
I
D
L
R
H
T
QTTINN
D
L
G
Y
I
E
R
Q
I
G
Q
I
T
S
R
I
D
KLDLENSHHV
D
D
R
K
D
M
L
A
Q
I
E
T
T
K
T
H
L
T
K
I
Q
S
E
L
T
E
Q
M
E
I
Y
R
E
V
Q
Q
T
L
A
K
Q
E
A
VFG
T
Q
E
R
A
L
Y
K
H
Y
E
T
V
Q
Q
M
K
S
R
K
E
T
L
E
E
L
A
D
D
Y
A
G
F
F
Q
G
V
R
E
V
L
K
A
K
KEI
P
G
I
L
G
A
L
V
E
L
V
EI
P
A
K
Y
Q
Q
A
M
E
T
A
LGASA
Q
N
V
V
VE
D
D
R
V
A
R
E
A
I
S
F
L
K
KTKSG
R
A
T
F
L
PLSTIQPRELP
A
A
T
K
N-ALSNQ
P
A
F
I
A
L
A
S
E
V
I
S
F
D-EK
V
S
P
V
I
L
N
A
L
G
T
T
I
L
A
K
D
LK
G
A
N
T
L
A
R
L
V
NF
R
Y
R
I
V
T
L
EG
D
V
VNAGGSMTGGATKGGK
S
S
I
L
T
R
K
H
E
L
G
-
Q
L
A
E
K
I
----
A
E
L
N
E
S
T
R
E
M
E
S
A
V
Q
L
A
K
D
S
M
A
K
K
R
E
E
L
E
E
T
R
V
I
GENLR
L
Q
E
K
E
L
L
G
K
LDR
E
T
E
N
L
E
R
F
N
K
Q
L
Q
L
Y
D
IEKAD
G
S
E
E
L
N
K
L
L
E
R
K
E
T
L
L
Q
E
Q
V
E
I
A
K
Q
IEV
T
D
E
E
I
K
A
M
TSS
S
K
A
L
E
S
K
R
AA
D
L
E
S
L
S
S
L
K
A
Q
I
A
A
K
R
E
Q
L
Q
S
A
T
E
A
V
E
R
V
T
T
T
L
H
EN
Y
E
Q
K
E
A
A
E
Q
K
L
A
S
L
K
TNL
T
S
VHT
S
E
E
T
A
R
K
S
I
-
E
E
L
RKDKT
E
T
S
E
K
L
T
Q
T
R
Q
T
R
A
E
L
Q
E
K
L
E
L
L
E
A
E
L
TQKNN
Q
I
S
F
Y
M
EQKNNA
E
I
S
I
G
R
L
E
V
D
I
A
N
R
----
I
D
R
L
Q
E
A
YLL
T
P
E
Q
A
E
E
K
I
L
S
E
V
N
T
----
E
Q
A
R
S
K
V
R
L
L
K
R
S
I
D
ELG
I
V
N
I
G
A
I
E
E
F
E
R
I
Q
E
R
F
D
F
LTGQ
Q
A
D
L
L
A
A
K
E
T
L
F
K
V
M
D
EM
D
E
E
M
K
I
R
FS
E
S
F
E
A
I
K
T
E
F
A
I
V
F
P
E
LFGGG
S
A
E
L
V
L
-LDP
E
N
LLTTG
I
D
I
V
VQPPG
K
K
L
Q
N
L
SLR--SG
G
E
R
A
L
T
A
I
A
L
L
F
A
I
I
RVRPV
P
F
C
I
L
D
E
V
E
A
A
L
D
E
A
N
V
T
R
F
S
R
Y
L
K
Q
F
ESG
T
Q
F
I
V
I
THRKGTMEEA
D
V
L
Y
G
V
T
M
Q
ES
G
V
S
K
L
V
S
V
R
L
E
E
T
A
E
L
IK
99
HHSearch
77.91
70%
-33
- C1 -
3ZGX
-
SMC_BACSU
A:
[994-1175]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
V
N
E
R
Y
K
F
L
S
E
Q
K
E
D
L
T
E
A
K
N
T
L
F
Q
V
I
E
E
M
D
E
E
M
T
K
R
F
N
D
T
F
V
Q
I
R
S
H
F
D
Q
V
F
R
S
L
F
G
G
G
R
A
E
L
R
L
-
T
D
P
N
D
L
L
H
S
G
V
E
I
I
A
Q
P
P
G
K
K
L
Q
N
L
N
L
L
--
S
G
G
E
R
A
L
T
A
I
A
L
L
F
S
I
L
K
V
R
P
V
P
F
C
V
L
D
E
V
E
A
A
L
D
E
A
N
V
F
R
F
A
Q
Y
L
K
K
Y
S
S
D
T
Q
F
I
V
I
T
H
R
K
G
T
M
E
E
A
D
V
L
Y
G
V
T
M
----
V
S
K
V
I
S
-----------
84
Fugue
71.57
18%
-4
* C1 *
4UX3
2
SMC3_YEAST
A:
[3-527]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
K
R
V
I
I
K
G
F
K
T
Y
R
N
E
T
I
I
D
N
F
S
--
P
H
Q
N
V
I
I
G
S
N
G
S
G
K
S
N
F
F
A
A
I
R
F
V
L
S
-----
D
D
Y
S
N
L
K
R
E
E
R
Q
G
L
I
H
Q
G
S
G
G
S
V
M
S
A
S
V
E
I
V
I
R
R
T
V
G
L
K
K
D
D
Y
Q
L
N
D
R
N
V
T
K
G
D
I
V
R
M
L
E
T
A
G
F
S
M
N
N
P
Y
N
I
V
P
Q
G
K
I
V
A
L
T
N
A
K
D
K
E
R
L
Q
L
L
E
D
V
V
G
A
K
S
F
E
V
K
L
K
A
S
L
K
K
M
E
E
T
E
Q
K
K
I
Q
I
N
K
E
M
G
E
L
N
S
K
L
S
E
M
E
Q
E
R
K
E
L
E
K
Y
N
E
L
E
----
R
N
R
K
I
Y
Q
F
T
L
Y
D
R
E
L
N
E
V
I
N
Q
M
E
T
S
----
D
Q
L
L
Q
R
L
N
D
M
N
T
E
I
S
G
L
K
N
V
N
K
R
A
F
E
N
F
K
K
F
N
E
R
R
K
D
L
A
E
R
A
S
E
L
D
E
S
K
D
S
I
Q
D
L
I
V
K
L
K
Q
Q
K
V
N
A
V
D
S
T
F
Q
K
V
S
E
N
F
E
A
V
F
E
R
L
V
P
R
G
T
A
K
L
I
I
---------
H
S
I
S
V
S
F
N
S
K
Q
N
E
Q
L
H
V
E
Q
L
--
S
G
G
Q
K
T
V
C
A
I
A
L
I
L
A
I
Q
M
V
D
P
A
S
F
Y
L
F
D
E
I
D
A
A
L
D
K
Q
Y
R
T
A
V
A
T
L
L
K
E
L
S
K
N
A
Q
F
I
C
T
T
F
R
T
D
M
L
Q
V
A
D
K
F
F
R
V
K
Y
E
N
K
-
I
S
T
V
I
E
V
N
R
E
E
A
I
G
F
I
R
81
Fugue
70.43
28%
-15
- C1 -
1E69
-
?
A:
[1-1164]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
K
K
L
Y
L
K
G
F
K
S
F
G
R
P
S
L
I
G
F
S
D
R
V
T
A
I
V
G
P
NGSG
K
S
N
I
I
D
A
I
K
W
V
F
G
E
K
F
D
M
I
F
A
G
S
E
N
LPPA
G
S
A
Y
V
E
L
V
F
E
E
N
G
E
E
I
T
V
A
R
E
L
K
R
T
G
E
N
T
Y
Y
L
N
G
S
P
V
R
L
K
D
I
R
D
R
F
A
G
T
G
L
G
V
D
F
Y
S
I
V
G
Q
G
Q
I
D
R
I
V
N
A
Y
Q
R
V
N
E
S
F
N
R
F
I
S
L
L
F
F
G
G
E
G
R
L
--------------
E
I
S
I
R
K
P
G
R
R
D
Q
K
L
S
L
L
--
S
G
G
E
K
A
L
V
G
L
A
L
L
F
A
L
M
E
I
K
P
S
P
F
Y
V
L
D
E
V
D
S
P
L
D
D
Y
N
A
E
R
F
K
R
L
L
K
E
N
S
K
H
T
Q
F
I
V
I
T
H
N
K
I
V
M
E
A
A
D
L
L
H
G
V
T
M
V
N
-
G
V
S
A
I
V
P
V
E
V
--------
4
PsiBlast_PDB
69.08
27%
-50
- C2 -
1GXL
-
?
A:
[479-679]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
E
I
Q
F
E
K
E
M
I
E
R
D
M
R
E
Y
R
G
F
S
R
A
V
R
A
V
F
E
E
K
E
R
F
P
G
L
V
D
V
V
S
N
L
I
E
V
D
E
K
Y
S
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
N
E
A
G
R
V
T
I
L
P
L
D
L
I
D
G
---
S
F
N
R
I
S
-
G
L
E
N
E
R
G
F
V
G
Y
A
V
D
L
V
K
F
P
-
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
E
-
R
S
S
N
V
F
E
R
R
I
K
L
K
-
H
L
E
Q
E
M
----
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
67.07
44%
-30
- C1 -
3KTA
1
?
B:
[5-158]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
N
V
F
M
R
T
F
E
A
I
S
R
N
F
S
E
I
F
A
K
L
S
P
G
G
S
A
R
L
I
L
-
E
N
P
E
D
P
F
S
G
G
L
E
I
E
A
K
P
A
G
K
D
V
K
R
I
E
A
M
--
S
G
G
E
K
A
L
T
A
L
A
F
V
F
A
I
Q
K
F
K
P
A
P
F
Y
L
F
D
E
I
D
A
H
L
D
D
A
N
V
K
R
V
A
D
L
I
K
E
S
S
K
E
S
Q
F
I
V
I
T
L
R
D
V
M
M
A
N
A
D
K
I
I
G
V
S
M
R
D
-
G
V
S
K
V
V
S
L
S
L
E
K
A
M
K
---
21
PsiBlast_CBE
65.50
42%
-34
- C1 -
1XEX
1
?
B:
[4-159]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
N
V
F
M
R
T
F
E
A
I
S
R
N
F
S
E
I
F
A
K
L
S
P
G
G
S
A
R
L
I
L
-
E
N
---
P
F
S
G
G
L
E
I
E
A
K
P
A
G
K
D
V
K
R
I
E
A
M
--
S
G
G
E
K
A
L
T
A
L
A
F
V
F
A
I
Q
K
F
K
P
A
P
F
Y
L
F
D
Q
I
D
A
H
L
D
D
A
N
V
K
R
V
A
D
L
I
K
E
S
S
K
E
S
Q
F
I
V
I
T
L
R
D
V
M
M
A
N
A
D
K
I
I
G
V
S
M
R
D
-
G
V
S
K
V
V
S
L
S
L
E
K
A
M
K
I
L
-
91
HHSearch
65.44
39%
-14
- C1 -
3KTA
2
SMC_PYRFU
A:
[2-169]
-------
P
Y
I
E
K
L
E
L
K
G
F
K
S
Y
G
N
K
-
K
V
V
I
P
F
S
K
G
-
F
T
A
I
V
G
A
N
G
S
G
K
S
N
I
G
D
A
I
L
F
V
L
G
G
L
S
A
K
A
M
R
A
S
R
I
S
D
L
I
F
A
G
S
----
P
A
K
Y
A
E
V
A
I
Y
F
N
N
E
D
R
G
F
P
I
D
E
D
E
V
V
I
R
R
R
V
Y
P
D
G
R
S
S
Y
W
L
N
G
R
R
A
T
R
S
E
I
L
D
I
L
T
A
A
M
I
S
P
D
G
Y
N
I
V
L
Q
G
D
I
T
K
F
I
K
M
S
P
L
E
R
R
L
L
I
D
D
I
S
G
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
HHSearch
65.31
76%
31
- C1 -
3ZGX
-
SMC_BACSU
A:
[1-978]
-------
M
F
L
K
R
L
D
V
I
G
F
K
S
F
A
E
R
-
I
-
S
V
D
F
V
K
G
-
V
T
A
V
V
G
P
---
G
K
S
N
I
T
D
A
I
R
W
V
L
G
E
Q
S
------------------------
L
A
E
V
T
L
T
L
D
N
D
D
H
F
L
P
I
D
-
H
E
V
S
V
T
R
R
V
Y
R
S
G
E
S
E
F
L
I
N
N
Q
P
C
R
L
K
D
I
I
D
L
F
M
D
-----
E
A
F
S
I
I
S
Q
G
K
V
E
E
I
L
S
S
K
A
E
D
R
R
S
I
F
E
E
A
A
G
V
L
K
Y
K
T
R
K
K
K
A
E
N
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
65.23
30%
-44
- C2 -
3L51
2
B:
[11-158]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
S
G
R
I
P
G
I
Y
G
R
L
G
D
L
G
A
I
D
E
K
Y
D
I
A
I
S
S
C
C
H
A
-
L
D
Y
I
V
V
D
S
I
D
T
A
Q
E
C
V
N
F
L
K
K
H
N
I
G
I
A
T
F
I
G
L
D
K
M
T
V
W
A
K
K
M
S
K
I
Q
-
T
P
E
N
T
P
R
L
F
D
L
---
V
K
V
K
N
-
E
E
I
R
Q
A
F
Y
F
A
L
R
D
T
L
V
A
N
N
L
D
Q
A
T
R
V
A
Y
Q
R
D
R
R
W
R
V
V
T
L
Q
G
Q
I
I
E
Q
S
G
T
M
S
G
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
65.21
29%
-59
- C2 -
1GXJ
-
?
A:
[498-656]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
R
A
V
R
A
V
F
E
E
K
E
R
F
P
G
L
V
D
V
V
S
N
L
I
E
V
D
E
K
Y
S
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
N
E
A
G
R
V
T
I
L
P
L
D
L
I
D
G
---
S
F
N
R
I
S
-
G
L
E
N
E
R
G
F
V
G
Y
A
V
D
L
V
K
F
P
-
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Fugue
65.14
29%
-54
- C2 -
1GXJ
-
?
A:
[498-658]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
R
A
V
R
A
V
F
E
E
K
E
R
F
P
G
L
V
D
V
V
S
N
L
I
E
V
D
E
K
Y
S
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
N
E
A
G
R
V
T
I
L
P
L
D
L
I
D
G
S
F
---
N
R
I
S
-
G
L
E
N
E
R
G
F
V
G
Y
A
V
D
L
V
K
F
P
-
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
64.87
32%
-36
- C2 -
4U4P
-
?
B:
[45-205]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
S
G
R
I
P
G
I
Y
G
R
L
G
D
L
G
A
I
D
E
K
Y
D
V
A
I
S
S
C
C
H
A
-
L
D
Y
I
V
V
D
S
I
D
I
A
Q
E
C
V
N
F
L
K
R
Q
N
I
G
V
A
T
F
I
G
L
D
K
M
A
V
W
A
K
K
M
T
E
I
Q
-
T
P
E
N
T
P
R
L
F
D
L
---
V
K
V
K
D
-
E
K
I
R
Q
A
F
Y
F
A
L
R
D
T
L
V
A
D
N
L
D
Q
A
T
R
V
A
Y
Q
K
D
R
R
W
R
V
V
T
L
Q
G
Q
I
I
E
Q
S
G
T
M
T
G
G
G
S
K
-------
V
M
K
G
R
M
G
S
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
64.70
39%
-11
- C1 -
3KTA
2
SMC_PYRFU
A:
[4-169]
---------
I
E
K
L
E
L
K
G
F
K
S
Y
G
N
K
K
V
-
V
I
P
F
S
K
G
-
F
T
A
I
V
G
A
N
G
S
G
K
S
N
I
G
D
A
I
L
F
V
L
G
G
L
S
A
K
A
M
R
A
S
R
I
S
D
L
I
F
A
G
S
----
P
A
K
Y
A
E
V
A
I
Y
F
N
N
E
D
R
G
F
P
I
D
E
D
E
V
V
I
R
R
R
V
Y
P
D
G
R
S
S
Y
W
L
N
G
R
R
A
T
R
S
E
I
L
D
I
L
T
A
A
M
I
S
P
D
G
Y
N
I
V
L
Q
G
D
I
T
K
F
I
K
M
S
P
L
E
R
R
L
L
I
D
D
I
S
G
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
64.36
25%
-16
- C1 -
4UX3
2
SMC3_YEAST
A:
[183-527]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
K
K
M
E
E
T
E
Q
K
K
I
-
Q
-
I
N
K
E
M
G
E
L
N
S
K
L
S
E
M
E
Q
E
R
K
E
L
E
K
Y
N
E
L
---
E
R
N
R
K
I
Y
Q
F
T
L
Y
D
R
E
L
N
E
V
I
N
Q
M
E
------------------------------------
T
S
----
D
Q
L
L
Q
R
L
N
D
M
N
T
E
I
S
G
L
K
N
V
N
K
R
A
F
E
N
F
K
K
F
N
E
R
R
K
D
L
A
E
R
A
S
E
L
D
E
S
K
D
S
I
Q
D
L
I
V
K
L
K
Q
Q
K
V
N
A
V
D
S
T
F
Q
K
V
S
E
N
F
E
A
V
F
E
R
L
V
P
R
G
T
A
K
L
I
I
H-----------
S
I
S
V
S
F
N
S
K
Q
N
E
Q
L
H
V
E
QL
S
G
G
Q
K
T
V
C
A
I
A
L
I
L
A
I
Q
M
V
D
P
A
S
F
Y
L
F
D
E
I
D
A
A
L
D
K
Q
Y
R
T
A
V
A
T
L
L
K
E
L
S
K
N
A
Q
F
I
C
T
T
F
R
T
D
M
L
Q
V
A
D
K
F
F
R
V
K
Y
-
E
N
K
I
S
T
V
I
E
V
N
R
E
E
A
I
G
F
I
R
7
PsiBlast_PDB
63.91
29%
-61
- C2 -
1GXK
-
?
A:
[501-656]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
V
R
A
V
F
E
E
K
E
R
F
P
G
L
V
D
V
V
S
N
L
I
E
V
D
E
K
Y
S
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
N
E
A
G
R
V
T
I
L
P
L
D
L
I
D
G
---
S
F
N
R
I
S
-
G
L
E
N
E
R
G
F
V
G
Y
A
V
D
L
V
K
F
P
-
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
63.20
39%
-16
- C1 -
1XEX
2
?
A:
[4-167]
---------
I
E
K
L
E
L
K
G
F
K
S
Y
G
N
K
K
V
-
V
I
P
F
S
K
G
-
F
T
A
I
V
G
A
N
G
S
G
K
S
N
I
G
D
A
I
L
F
V
L
G
G
L
S
A
K
A
M
R
A
S
R
I
S
D
L
I
F
A
G
S
K
N
E
P
P
A
K
Y
A
E
V
A
I
Y
F
N
N
E
D
R
G
F
P
I
D
E
D
E
V
V
I
R
R
R
V
Y
P
D
G
R
S
S
Y
W
L
N
G
R
R
A
T
R
S
E
I
L
D
I
L
T
A
A
M
I
S
P
D
G
Y
N
I
V
L
Q
G
D
I
T
K
F
I
K
M
S
P
L
E
R
R
L
L
I
D
D
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
HHSearch
62.37
30%
-45
- C2 -
3L51
2
B:
[16-159]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
G
I
Y
G
R
L
G
D
L
G
A
I
D
E
K
Y
D
I
A
I
S
S
C
C
H
-
A
L
D
Y
I
V
V
D
S
I
D
T
A
Q
E
C
V
N
F
L
K
K
H
N
I
G
I
A
T
F
I
G
L
D
K
M
T
V
W
A
K
K
M
S
-----
K
I
Q
T
P
E
N
T
P
R
L
F
D
L
V
K
V
K
N
E
E
I
R
Q
A
F
Y
F
A
L
R
D
T
L
V
A
N
N
L
D
Q
A
T
R
V
A
Y
Q
R
D
R
R
W
R
V
V
T
L
Q
G
Q
I
I
E
Q
S
G
T
M
S
G
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
61.35
25%
-34
- C2 -
4RSI
1
A:
[128-341]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
G
V
V
G
Q
L
F
Q
I
D
N
D
N
I
R
Y
A
T
A
L
Q
T
C
A
G
G
R
L
F
N
V
V
V
Q
D
S
Q
T
A
T
Q
L
L
E
R
G
R
L
R
K
--
R
V
T
I
I
P
L
D
K
I
Y
T
R
P
I
S
S
Q
V
L
D
L
A
K
K
I
A
P
G
K
V
E
L
A
I
N
L
I
R
F
D
-
E
S
I
T
K
A
M
E
F
I
F
G
N
S
L
I
C
E
D
P
E
T
A
K
K
I
T
F
H
P
K
I
R
A
R
S
I
T
L
Q
G
D
V
Y
D
P
E
G
T
L
S
G
G
S
-
R
---
E
S
L
L
V
D
I
Q
K
Y
N
-
Q
I
Q
K
Q
I
E
T
I
Q
A
D
L
N
H
V
T
E
E
L
Q
T
Q
Y
A
T
S
-----------
Q
K
T
K
T
I
Q
S
D
L
N
L
S
----
L
H
K
L
D
L
A
K
R
N
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
HHSearch
61.26
28%
-53
- C2 -
1GXJ
-
?
A:
[512-658]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
P
G
L
V
D
V
V
S
N
L
I
E
V
D
E
K
Y
S
L
A
V
S
V
L
L
G
G
T
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
N
E
A
G
R
V
T
I
L
P
L
D
L
I
D
G
S
F
N
R
I
S
----
G
L
E
N
E
R
G
F
V
G
Y
A
V
D
L
V
K
F
P
-
S
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Fugue
61.23
22%
35
- C1 -
1E69
-
?
A:
[1-1164]
MRLK
K
L
Y
L
K
G
F
K
-------
S
F
G
R
P
-
S
-
L
I
G
F
S
D
-
R
V
T
A
I
V
G
P
N
G
S
G
K
S
N
I
I
D
A
I
K
W
V
F
G
E
----------
K
F
D
M
I
F
A
G
S
E
N
L
P
P
A
G
S
A
Y
V
E
L
V
F
E
E
N
G
-------
E
E
I
T
V
A
R
E
L
K
R
T
---
G
E
N
T
Y
Y
L
N
---
G
S
P
V
-----
R
L
K
D
I
R
D
R
F
A
---------------
G
T
G
L
G
V
D
F
Y
--
S
I
V
G
Q
G
Q
I
D
R
I
V
N
-------
A
Y
Q
R
V
N
E
S
F
N
R
F
I
S
L
L
F
F
G
--
G
E
G
R
L
-------
E
I
S
I
R
K
P
G
R
R
D
Q
K
L
S
L
L
S
G
G
E
K
A
L
V
G
L
A
L
L
F
A
L
M
E
I
K
P
--
S
P
-
F
Y
V
L
D
E
V
D
S
P
L
D
D
Y
N
A
E
R
F
K
R
L
L
K
E
N
S
K
H
T
Q
F
I
V
I
T
H
N
K
-
I
V
M
E
A
A
D
L
L
H
G
V
T
M
V
N
G
V
S
A
I
V
P
V
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------