@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1960: (2016-03-30 )
MKDLHTDNLQISYDKRIIVDGLDIAIPANKITALVGANGSGKSTILKTMSRLMKPSKGAVYLDGKTIHSQPTRDVAKQLAILPQNPSAPDGLTVFELISYGRSPHQSSFKSITAKDREIIFWSLRVTNLTEFADRPIDSLSGGQRQRAWIAMALAQETDVLFLDEPTTFLDMTHQLDVLNLLKQLNQSENRTIVMVVHDLNHASRYAHHMIAIKEGKVIAEGTPTSVMTEQTLEDVFNIKADILIDPRSGVPLCLPYETCNGCEIVKELDSIAK
Atome Classification :
(31 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10..-.-.----..---..20........30........40........50........60......--..--70------------..--.---..-....80.....-.-..-90........100-....-..-----..-110---.......120..--...-..130-----------..-......140.......150....------...160.......170.......180.......190.......200.......210.......220.......230........--240.......250.......260.......270..----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKDLHTD
N
L
Q
I
S
Y-D-
K
----
R
I
---
I
VDG
L
D
I
A
IPAN
K
I
T
A
L
VGANGS
G
K
S
T
I
L
K
T
M
S
R
LMKPSK
G
A
V
Y
LDGKTI--HS--Q-------------
P
T
--
R
---
D
V
-
A
K
Q
L
AILPQNP-S-AP-D
G
L
T
V
F
E
L
I
SYG--RSPH-
Q
S
-----
S
F
-
K
SI---TAKD
R
E
I
I
F
W
S
L
--
R
VT-
N
L
T
-
E
-----------
F
A-DRP
I
D
SLSGGQ
R
Q
R
A
W
I
A
M
A
LAQ------ET
D
V
L
F
LDEP
T
T
F
L
D
M
T
H
Q
L
D
V
L
N
L
L
K
Q
L
NQSEN
R
T
I
V
M
V
V
HDLN
H
A
S
R
Y
A
H
H
M
I
A
I
KE
G
K
V
I
AEGTPT
S
V
M
T
E
-
Q
T
L
E
D
V
FNI--K
A
D
I
L
IDPRSG
V
P
L
C
L
PYETC
N
G
C
E
I
V
K
E
L
D
S
IAK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
97.85
31%
-110
- C1 -
4G1U
1
HMUV_YERPE
D:
[12-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
S
H
L
H
Y
H
V
-
Q
-
Q
----
Q
A
---
L
I
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
H
G
E
C
H
L
L
G
Q
N
L
--
N
S
--
W
-------------
Q
P
--
K
---
A
L
-
A
R
T
R
A
V
M
R
Q
Y
S
-
E
-
L
A
-
F
P
F
S
V
S
E
V
I
Q
M
G
--
R
A
P
Y
-
G
G
-----
S
----------
Q
D
R
Q
A
L
Q
Q
V
M
--
A
Q
T
-
D
C
L
-
A
-----------
L
A
-
Q
R
D
Y
R
V
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
LWQPQP
T
P
R
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
L
T
R
Q
E
P
L
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
M
L
L
A
Q
G
K
L
V
A
C
G
T
P
E
E
V
L
N
A
-
E
T
L
T
Q
W
Y
Q
A
--
D
L
G
V
S
R
H
P
E
S
A
L
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.47
31%
-110
- C1 -
4G1U
1
HMUV_YERPE
C:
[12-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
S
H
L
H
Y
H
V
-
Q
-
Q
----
Q
A
---
L
I
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
H
G
E
C
H
L
L
G
Q
N
L
--
N
S
--
W
-------------
Q
P
--
K
---
A
L
-
A
R
T
R
A
V
M
R
Q
Y
S
-
E
-
L
A
-
F
P
F
S
V
S
E
V
I
Q
M
G
--
R
A
P
Y
-
G
G
-----
S
----------
Q
D
R
Q
A
L
Q
Q
V
M
--
A
Q
T
-
D
C
L
-
A
-----------
L
A
-
Q
R
D
Y
R
V
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
L
WQPQP
T
P
R
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
L
T
R
Q
E
P
L
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
M
L
L
A
Q
G
K
L
V
A
C
G
T
P
E
E
V
L
N
A
-
E
T
L
T
Q
W
Y
Q
A
--
D
L
G
V
S
R
H
P
E
S
A
L
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
87.11
31%
-89
- C1 -
2IT1
1
?
B:
[2-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
I
K
L
E
N
I
V
K
K
F
-
G
-
N
----
F
T
---
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
--
T
E
--
L
-------------
P
P
--
K
---
D
---
R
N
V
G
L
V
F
Q
N
W
-
A
-
L
Y
-
P
H
M
T
V
Y
K
N
I
A
F
P
--
L
E
L
R
-
K
A
-----
P
R
-
E
E
I
---
D
K
K
V
R
E
V
A
------
K
M
L
-
H
I
D
-
K
-----------
L
L
-
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
------
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
83.67
29%
-93
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[5-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
I
L
K
V
E
E
L
N
Y
N
Y
-
S
-
D
G---
T
H
---
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
K
P
I
--
D
Y
--
S
R
K
-----------
G
I
--
M
---
K
L
-
R
E
S
I
G
I
V
F
Q
D
P
-
D
N
Q
L
-
F
S
A
S
V
Y
Q
D
V
S
F
G
--
A
V
N
M
-
K
L
-----
P
--------
E
D
E
I
R
K
R
V
D
N
A
L
--
K
R
T
-
G
I
E
-
H
-----------
L
K
-
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
------
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
A
E
-
K
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.49
28%
-97
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[8-249]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
V
E
E
L
N
Y
N
Y
S
D
-
G
----
T
H
---
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
K
P
I
DY
S
R
--
K
-------------
G
I
--
M
---
K
L
-
R
E
S
I
G
I
V
F
Q
D
P
D
N
-
Q
L
-
F
S
A
S
V
Y
Q
D
V
S
F
G
-------
A
V
-----
N
M
-
K
L
P
---
E
D
E
I
R
K
R
V
D
N
A
L
--
K
R
T
-
G
I
E
-
H
-----------
L
K
-
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
------
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
A
E
-
K
E
V
I
R
K
V
N
L
--
R
L
-----
P
R
I
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
83.26
32%
-93
- C1 -
1B0U
4
HISP_SALTY
A:
[5-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
H
V
I
D
L
H
K
R
Y
-
G
-
G
----
H
E
---
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
--
N
L
--
V
R
D
KDGQLKVAD
K
N
Q
L
--
R
---
L
L
-
R
T
R
L
T
M
V
F
Q
H
F
-
N
-
L
W
-
S
H
M
T
V
L
E
N
V
M
E
A
--
P
I
Q
V
-
L
G
-----
L
----
S
---
K
H
D
A
R
E
R
A
L
K
Y
L
--
A
K
V
-
G
I
D
-
E
-----------
R
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
------
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
80.91
31%
-83
- C1 -
2IT1
-
?
A:
[1-221]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
E
I
K
L
E
N
I
V
K
K
F
-
G
-
N
----
F
T
---
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
--
T
E
--
L
-------------
P
P
--
K
---
D
---
R
N
V
G
L
V
F
Q
N
W
-
A
-
L
Y
-
P
H
M
T
V
Y
K
N
I
A
F
P
--
L
E
L
R
-
K
A
-----
P
R
-
E
E
I
---
D
K
K
V
R
E
V
A
------
K
M
L
-
H
I
D
-
K
-----------
L
L
-
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
------
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
79.63
25%
-94
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-224]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
-
G
-
E
----
V
V
---
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
--
N
D
--
T
-------------
P
P
-------
A
-
E
R
G
V
G
M
V
F
Q
S
Y
-
A
-
L
Y
-
P
H
L
S
V
A
E
N
M
S
F
G
--
L
K
L
A
-
G
A
-----
K
--------
K
E
V
I
N
Q
R
V
N
Q
V
A
--
E
V
L
-
Q
L
A
-
H
-----------
L
L
-
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
------
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
79.54
29%
-88
- C1 -
2IT1
-
?
A:
[1-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
E
I
K
L
E
N
I
V
K
K
F
-
G
-
N
----
F
T
---
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
--
T
E
--
L
-------------
P
P
-------
K
-
D
R
N
V
G
L
V
F
Q
N
W
-
A
-
L
Y
-
P
H
M
T
V
Y
K
N
I
A
F
P
--
L
E
L
R
-
K
A
-----
P
--------
R
E
E
I
D
K
K
V
R
E
V
A
--
K
M
L
-
H
I
D
-
K
-----------
L
L
-
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
------
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
78.93
30%
-104
- C1 -
4MKI
4
ECFA2_CALS4
B:
[30-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
--
T
D
--
K
-------------
K
V
S
L
K
---
D
I
-
R
K
Q
V
G
L
V
F
Q
Y
P
-
E
-
Y
Q
L
F
E
E
T
V
F
K
D
I
A
F
G
----
P
S
-
N
L
-----
G
L
-
S
E
E
---
E
V
K
E
R
--
V
Y
E
A
M
--
E
I
V
-
G
I
S
K
E
-----------
L
A
-
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
------
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
A
E
R
L
E
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
77.94
27%
-96
- C1 -
2OLJ
4
?
A:
[22-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
M
I
D
V
H
Q
L
K
K
S
F
-
G
-
S
----
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
--
K
A
KD
T
-------------
N
L
--
N
---
K
V
-
R
E
E
V
G
M
V
F
Q
R
F
-
N
-
L
F
-
P
H
M
T
V
L
N
N
I
T
L
A
--
P
M
K
V
-
R
K
-----
W
P
-------
R
E
K
A
E
A
K
A
M
E
L
L
--
D
K
V
-
G
L
K
-
D
-----------
K
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
77.23
25%
-100
* C1 *
3TUI
1
METN_ECOLI
C:
[23-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
-
H
-
Q
GTRT
I
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
--
T
T
--
L
-------------
S
E
--
S
ELT
K
A
-
R
R
Q
I
G
M
I
F
Q
H
F
-
N
-
L
L
-
S
S
R
T
V
F
G
N
V
A
L
P
--
L
E
L
D
-
N
T
-----
P
--------
K
D
E
V
K
R
R
V
T
E
L
L
--
S
L
V
-
G
L
G
-
D
-----------
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
------
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
76.18
26%
-102
- C1 -
1G6H
3
LIVG_METJA
A:
[5-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
L
R
T
E
N
I
V
K
Y
F
-
G
-
E
----
F
K
---
A
L
D
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
E
N
K
D
I
--
T
N
--
K
-------------
E
P
--
A
---
E
L
Y
H
Y
G
I
V
R
T
F
Q
T
P
-
Q
-
P
L
-
K
E
M
T
V
L
E
N
L
L
I
G
--
E
I
C
P
-
G
E
S
P
L
N
S
L
F
Y
K
K
W
IPK
E
E
E
M
V
E
K
A
F
K
I
L
--
E
F
L
-
K
L
S
-
H
-----------
L
Y
-
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
------
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
K
A
-
K
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
G
Q
I
I
A
E
G
R
G
E
E
E
I
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
75.36
26%
-100
- C1 -
1JI0
1
?
A:
[6-230]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
E
V
Q
S
L
H
V
Y
Y
-
G
-
A
----
I
H
---
A
I
K
G
I
D
L
K
V
P
R
G
Q
I
V
T
L
I
G
A
N
G
A
G
K
T
T
T
L
S
A
I
A
G
L
V
R
A
Q
K
G
K
I
I
F
N
G
Q
D
I
--
T
N
--
K
-------------
P
A
--
H
---
V
I
N
R
M
G
I
A
L
V
P
E
G
R
-
R
-
I
F
-
P
E
L
T
V
Y
E
N
L
M
M
G
--
A
Y
N
R
-
K
D
--------------
K
E
G
I
K
R
D
L
E
W
I
F
--
S
L
F
P
R
L
K
-
E
-----------
R
L
-
K
Q
L
G
G
T
L
S
G
G
E
Q
Q
M
L
A
I
G
R
A
L
M
S
------
R
P
K
L
L
M
M
D
E
P
S
L
G
L
A
P
I
L
V
S
E
V
F
E
V
I
Q
K
I
N
Q
-
E
G
T
T
I
L
L
V
E
Q
N
A
L
G
A
L
K
V
A
H
Y
G
Y
V
L
E
T
G
Q
I
V
L
E
G
K
A
S
E
L
L
D
N
-
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
74.79
28%
-75
- C1 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
E
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
QE
I
S
W
F
D
T
N
HSGT
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
GD
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
NG
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
GSLN
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
LDRKPVIDSS
S
K
A
G
R
KDMKI
K
G
D
I
T
V
E
N
V
H
F
T
Y
-
P
-
S
----
R
P
DVP
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
K
G
K
I
T
I
D
G
V
D
V
--
R
D
--
I
-------------
N
L
--
E
---
F
L
-
R
K
N
V
A
V
V
S
Q
E
P
-
A
-
L
F
-
N
-
C
T
I
E
E
N
I
S
L
G
--
K
E
G
I
T
R
E
-----
E
M
-
V
A
A
---
C
K
M
A
N
A
E
K
F
I
K
T
--
L
P
N
-
G
Y
N
-
T
-----------
L
V
-
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
------
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
A
A
K
--
G
R
T
T
I
I
I
A
H
R
L
S
T
I
-
R
N
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
Q
-
Q
G
------------------------
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
GER
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
ENNAQKTN
L
F
E
I
L
Y
H
A
RPH
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
AGNPADFL
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
QHIGFFDSPQNA
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RRFTGKNVKSA
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
AR
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKKKLYGK
V
I
F
K
N
V
R
F
A
Y
PERPEIEILK
G
L
S
F
S
V
E
PG
Q
T
L
A
L
V
G
P
S
GCGKST
V
V
A
L
L
E
RFYDTL
G
G
E
I
F
I
DGSEIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
DCS
I
A
E
N
I
I
YGLDPSSVT
M
A
Q
V
E
E
A
A
R
L
A
NI
H
N
F
I
A
E
LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
53
Fugue
74.06
25%
-84
- C1 -
1Z47
1
?
A:
[11-355]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G
S
M
T
I
E
F
V
G
V
E
K
I
Y
-
P
-
G
----
G
A
R--
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
--
T
D
--
L
-------------
P
P
--
Q
---
K
---
R
N
V
G
L
V
F
Q
N
Y
-
A
-
L
F
-
Q
H
M
T
V
Y
D
N
V
S
F
G
--
L
R
E
K
-
R
V
-----
P
--------
K
D
E
M
D
A
R
V
R
E
L
L
--
R
F
M
-
R
L
E
-
S
-----------
Y
A
-
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
------
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
-
P
G
T
L
F
V
A
S
F
IG
E
S
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
A
G
A
A
L
P
V
D
P
A
V
S
E
G
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.98
30%
-111
- C1 -
2NQ2
-
Y1470_HAEIN
C:
[3-227]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
S
V
E
N
L
G
F
Y
Y
-
Q
A
E
----
N
F
---
L
F
Q
Q
L
N
F
D
L
N
K
G
D
I
L
A
V
L
G
Q
N
G
C
G
K
S
T
L
L
D
L
L
L
G
I
H
R
P
I
Q
G
K
I
-----------------------------------
E
V
-
Y
Q
S
I
G
F
V
P
Q
F
F
-
S
-
S
P
-
F
A
Y
S
V
L
D
I
V
L
M
G
--
R
S
T
H
-
I
N
-----
T
F
-
A
K
P
---
K
S
H
D
Y
Q
V
A
M
Q
A
L
--
D
Y
L
-
N
L
T
-
H
-----------
L
A
-
K
R
E
F
T
S
L
S
G
G
Q
R
Q
L
I
L
I
A
R
A
I
A
S
------
E
C
K
L
I
L
L
D
E
P
T
S
A
L
D
L
A
N
Q
D
I
V
L
S
L
L
I
D
L
A
Q
S
Q
N
M
T
V
V
F
T
T
H
Q
P
N
Q
V
V
A
I
A
N
K
T
L
L
L
N
K
Q
N
-
F
K
F
G
E
T
R
N
I
L
T
S
-
E
N
L
T
A
L
F
H
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
73.02
31%
-82
- C1 -
3B60
2
MSBA_SALTY
A:
[341-568]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
E
F
R
N
V
T
F
T
Y
-
P
-
G
RE--
V
P
---
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
--
R
E
--
Y
-------------
T
L
--
A
---
S
L
-
R
N
Q
V
A
L
V
S
Q
N
V
-
H
-
L
F
-
N
D
-
T
V
A
N
N
I
A
Y
A
--
R
T
E
E
-------------------
Y
S
R
E
Q
I
E
E
A
A
--
R
M
A
-
Y
A
M
-
D
F
I
N
K
M
DNGLD
T
I
I
-
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
------
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
-
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
72.22
29%
-92
- C1 -
1Z47
1
?
A:
[14-236]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
E
F
V
G
V
E
K
I
Y
-
P
G
G
----
A
R
---
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
--
T
D
--
L
-------------
P
P
-------
Q
-
K
R
N
V
G
L
V
F
Q
N
Y
-
A
-
L
F
-
Q
H
M
T
V
Y
D
N
V
S
F
G
--
L
R
E
K
-
R
V
-----
P
--------
K
D
E
M
D
A
R
V
R
E
L
L
--
R
F
M
-
R
L
E
-
S
-----------
Y
A
-
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
------
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
71.75
33%
-82
- C1 -
2IXF
4
TAP1_RAT
B:
[34-244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
--
V
Q
--
Y
-------------
D
H
--
H
---
Y
L
-
H
T
Q
V
A
A
V
G
Q
E
P
-
L
-
L
--
F
G
R
S
F
R
E
N
I
A
Y
G
LT
R
T
P
T
-
M
E
-----
E
I
-
T
A
V
---
A
M
E
S
G
A
H
D
F
I
S
G
--
F
P
Q
-
G
Y
D
-
T
-----------
E
V
-
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
------
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
69.58
33%
-81
- C1 -
2IXF
5
TAP1_RAT
A:
[34-244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
--
V
Q
--
Y
-------------
D
H
--
H
---
Y
L
-
H
T
Q
V
A
A
V
G
Q
E
P
-
L
-
L
--
F
G
R
S
F
R
E
N
I
A
Y
G
LT
R
T
P
T
-
M
E
-----
E
I
-
T
A
V
---
A
M
E
S
G
A
H
D
F
I
S
G
--
F
P
Q
-
G
Y
D
-
T
-----------
E
V
-
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
------
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
69.36
33%
-74
- C1 -
2IXF
4
TAP1_RAT
C:
[34-244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
--
V
Q
--
Y
-------------
D
H
--
H
---
Y
L
-
H
T
Q
V
A
A
V
G
Q
E
P
-
L
-
L
--
F
G
R
S
F
R
E
N
I
A
Y
G
L
T
R
T
P
T
-
M
E
-----
E
I
-
T
A
V
---
A
M
E
S
G
A
H
D
F
I
S
G
--
F
P
Q
-
G
Y
D
-
T
-----------
E
V
-
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
------
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
67.01
33%
-77
- C1 -
2IXF
4
D:
[34-244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
--
V
Q
--
Y
-------------
D
H
--
H
---
Y
L
-
H
T
Q
V
A
A
V
G
Q
---
L
-
L
--
F
G
R
S
F
R
E
N
I
A
Y
G
LT
R
T
P
T
-
M
E
-----
E
I
-
T
A
V
---
A
M
E
S
G
A
H
D
F
I
S
G
--
F
P
Q
-
G
Y
D
-
T
-----------
E
V
-
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
------
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
65.57
32%
-85
- C1 -
4K8O
4
A:
[34-244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
--
V
Q
--
Y
-------------
D
H
--
H
---
Y
L
-
H
T
Q
V
A
A
V
G
Q
E
P
-
L
-
L
--
F
G
R
S
F
R
E
N
I
A
Y
G
LT
R
T
P
T
-
M
E
-----
E
I
-
T
A
V
---
A
M
E
S
G
A
H
D
F
I
S
G
--
F
P
Q
-
G
Y
D
-
T
-----------
E
V
-
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
------
K
P
R
L
L
I
L
D
N
A
T
S
A
L
A
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
64.92
32%
-87
- C1 -
2IXG
2
A:
[34-244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
--
V
Q
--
Y
-------------
D
H
--
H
---
Y
L
-
H
T
Q
V
A
A
V
G
Q
E
P
-
L
-
L
--
F
G
R
S
F
R
E
N
I
A
Y
G
LT
R
T
P
T
-
M
E
-----
E
I
-
T
A
V
---
A
M
E
S
G
A
H
D
F
I
S
G
--
F
P
Q
-
G
Y
D
-
T
-----------
E
V
-
G
E
T
G
N
Q
L
A
V
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
------
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
63.74
32%
-103
- C1 -
4YMU
2
?
A:
[16-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
--
N
N
--
G
-------------
K
V
--
N
I
N
-
K
V
-
R
Q
K
V
G
M
V
F
Q
H
F
-
N
-
L
F
-
P
H
L
T
A
I
E
N
I
T
L
----
A
P
---
V
-----
K
V
-
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
-
L
L
D
-
K
-----------
K
D
-
Q
Y
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
------
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
62.86
33%
-82
- C1 -
2IXE
3
TAP1_RAT
A:
[34-244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
--
V
Q
--
Y
-------------
D
H
--
H
---
Y
L
-
H
T
Q
V
A
A
V
G
Q
E
P
-
L
-
L
--
F
G
R
S
F
R
E
N
I
A
Y
G
LT
R
T
P
T
-
M
E
-----
E
I
-
T
A
V
---
A
M
E
S
G
A
H
D
F
I
S
G
--
F
P
Q
-
G
Y
D
-
T
-----------
E
V
-
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
------
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
62.18
32%
-104
- C1 -
4YMV
1
?
J:
[16-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
--
N
N
--
G
-------------
K
V
--
N
IN-
K
V
-
R
Q
K
V
G
M
V
F
Q
H
F
-
N
-
L
F
-
P
H
L
T
A
I
E
N
I
T
L
----
A
P
---
V
-----
K
V
-
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
L
LA
K
V
G
-
L
L
D
-
K
-----------
K
D
-
Q
Y
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
------
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
62.12
33%
-90
- C1 -
2IXE
3
D:
[34-244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
K
V
L
L
D
G
E
P
L
--
V
Q
--
Y
-------------
D
H
--
H
---
Y
L
-
H
T
Q
V
A
A
V
G
--
P
-
L
-
L
--
F
G
R
S
F
R
E
N
I
A
Y
G
LT
R
T
P
T
-
M
E
-----
E
I
-
T
A
V
---
A
M
E
S
G
A
H
D
F
I
S
G
--
F
P
Q
-
G
Y
D
-
T
-----------
E
V
------
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
------
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
60.42
32%
-103
- C1 -
4YMU
2
?
J:
[16-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
--
N
N
--
G
-------------
K
V
--
N
IN-
K
V
-
R
Q
K
V
G
M
V
F
Q
H
F
-
N
-
L
F
-
P
H
L
T
A
I
E
N
I
T
L
----
A
P
---
V
-----
K
V
-
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
L
LA
K
V
G
-
L
L
D
-
K
-----------
K
D
-
Q
Y
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
------
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
59.92
32%
-102
- C1 -
4YMV
1
?
A:
[16-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
--
N
N
--
G
-------------
K
V
--
N
I
N
-
K
V
-
R
Q
K
V
G
M
V
F
Q
H
F
-
N
-
L
F
-
P
H
L
T
A
I
E
N
I
T
L
----
A
P
---
V
-----
K
V
-
K
K
M
---
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
-
L
L
D
-
K
-----------
K
D
-
Q
Y
P
I
-
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
------
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------