@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2073: (2016-03-31 )
MILLQVQQISKFFGAEVILDNIKLEVKTGDRIALVGRNGAGKSTLLKIIAGKMSYDGGTISKPKSVEIGYLAQNTGLESSKTIWDEMLSVFDSLRKMEADLRKMELRLGEPELYNDPEKYQALMTDYDTLQHTFKESGGYTYEAEIRSVLNGLRFYPEDYEVEIASLSGGQKTRLALAKLLLAKQDILVLDEPTNHLDIETLAWLETYLQNYHGSLLIVSHDRYFLDKVVNQVYEISRTKIDYYKGNYSSFVNQKQAKLEQMWKEFDKQQKQIAKLEDFVARNIVRASTTKRAQSRRKQLEKMDVLGRPQGDEKAAHFGFQFEKQTGKDVLMVDQLSIGYAKDKRIASNLTFEMKRQDSLALVGPNGIGKSTLLKTLIRDIPALSGEFHFGAGVKIGYYDQEQAKLTSNKTVLMELWDDYPELNEVNVRTTLGNFLFSDDDVLKNVQSLSGGEKARLALAKLTLLEANVLILDEPTNHLDIESKEVLEAALIDFEGTILFVSHDRYFINRIASKIVELAPEKATVFLGDYDYYQEKLAEEKELARLDAEDRRKKGEQVEATASVRKLNYQEEKEQQKLLRQRKRKLEEIEKSMEETDEKIAELELQLTNPEVFQDHEKALEITQELDAVKADGEKLMEEWEQISEELESI
Atome Classification :
(20 SA)
------------------------------------------------------------------.........10...-.-------.-...----20...----..-...30........40........50......--..60...--------------.--...--.70.....-..-.--80...--.....90--........100.......110....--.----..-120.......130.......140..----.....150.......160.......170.......180...--....190.......----200-.........210----...---....220.......230....------...240.......250......--.260.......270.......280..-.....290.......300.......310.......320-........330.......340-.......350.......360.......370.......380.---------------------....-------..390..-----------.....400-.....-.------------------------------------------------------------------------.--..410......------------------------------------------------------------------.-----------------------------------------420---.----.--.....430.......440........450.......460.....---..470.......480.......490----..----...----..500.......510.......------520.-........530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------
M
I
L
L
Q
V
Q
Q
I
S
K
F
F
G
-
A
-------
E
-
V
I
L
----
D
N
I
K
L
----
E
V
-KTG
D
R
I
A
L
V
GRNGA
G
K
S
T
L
L
K
I
I
A
GKMSYDG--GTISKPK--------------
S
--
V
E
I
--
G
Y
L
A
QNTG-LE-
S
--
S
K
T
I
W
--
D
E
M
L
S
V
F
--
D
S
L
R
K
M
E
A
D
L
R
K
M
E
LRLGEPELYN
D
--
P
----
E
K
-
Y
Q
A
L
M
T
D
Y
D
T
L
Q
H
T
F
K
ESG
G
Y
T
Y
E
A
----
E
I
R
S
V
L
N
G
L
RFYPED
Y
E
V
E
I
A
SLSGG
Q
K
T
R
L
A
L
A
K
L
L
LAKQ--
D
I
L
V
LDEPTNHL
D
I
----
E
---
T
L
A
W
L
E
T
Y
L
Q
NY----HG
S
---
L
L
I
V
SH
D
R
Y
F
L
D
K
V
V
N
Q
V
Y
E
I
------SR
T
K
I
D
Y
YKG
N
Y
S
S
F
V
N
Q
K
Q
A
K
--
L
E
Q
M
W
K
E
F
D
K
Q
Q
K
Q
I
A
K
L
E
D
F
V
A
R
N
I
-
V
R
A
S
T
T
K
R
A
Q
S
R
R
K
Q
L
E
K
M
DVLGRPQGD
E
K
A
AHF
G
F
Q
--
F
EKQTGK
D
V
L
M
V
D
Q
LSIGYAK-D
K
R
I
A
SN
L
T
F
E
M
KRQD
S
L
A
L
VGPNGI
G
K
S
T
L
L
K
T
L
I
R
DIPA---------------------LSG
E
-------
F
HFGA
G
V
-----------
K
I
G
Y
Y
D
---
Q
E
Q
AK-L------------------------------------------------------------------------T--SN
K
T
V
L
M
E
L
W
D------------------------------------------------------------------D-----------------------------------------YPE---L----N--E
V
N
V
R
T
TLGNFLFS
D
D
D
-
V
L
K
N
V
Q
S
LSGG
E
K
A
R
L
A
L
A
K
L
T
L
L
E
A
---
N
V
L
I
LDEPTNHLDI
E
S
K
E
V
L
E
A
A
L
I----DF----E
G
T
----
I
L
F
V
SH
D
R
Y
F
I
N
R
I
A
S
K
I
V
E
LA------P--E-
K
A
T
V
F
LG
D
Y
D
Y
Y
Q
E
K
L
A
E
E
K
E
L
A
RL
D
A
E
D
R
RKKGE
Q
V
E
A
T
A
S
V
R
KL
N
Y
Q
E
E
K
E
Q
Q
K
L
L
R
Q
R
K
R
K
L
E
E
I
E
K
S
M
E
E
T
D
E
K
I
A
E
L
E
L
Q
LT
N
P
E
V
F
Q
D
H
E
K
A
L
E
I
T
Q
E
L
D
A
VKA
D
G
E
K
L
M
E
E
W
E
Q
I
S
E
E
L
ESI
2
PsiBlast_PDB
88.12
35%
-74
- C3 -
4FIN
12
ETTA_ECOLI
A:
[21-532]
--------------------------------------------------------------------------------------------
I
L
----
K
N
I
S
L
----
S
F
-
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
I
E
--
G
E
A
R
P
Q
P
--------------
D
--
I
K
I
--
G
Y
L
P
Q
E
P
Q
-
L
N
-
P
--
E
H
T
V
R
--
E
---
S
I
E
--
E
A
V
S
E
V
V
N
A
L
K
R
L
D
E
V
Y
A
---
L
Y
A
D
--
P
----
D
A
D
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
I
Q
------
L
N
V
----
Q
L
E
R
A
A
D
A
L
R
L
--
P
D
W
D
A
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
--
D
M
L
L
L
D
E
P
T
N
H
L
D
A
----
E
---
S
V
A
W
L
E
R
F
L
H
D
F
----
E
G
T
---
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
------
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
--
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
T
K----
K
G
K
A
R
L
A
R
F
E
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
F
I
P
P
G
------
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
--
D
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
---------------------
D
S
G
T
-------
I
T
L
G
E
T
V
-----------
K
L
A
S
V
D
---
Q
F
R
D
S
-
M
------------------------------------------------------------------------
D
--
N
S
K
T
V
W
E
E
V
S
G
GL----------------------------------------------------------------
D
-----------------------------------------
I
M
K
---
I
----
G
NT
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
V
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
---
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
----
E
F
----
P
G
C
----
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
------
D
--
E
G
K
V
E
F
F
E
G
N
F
T
E
Y
E
E
-------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.58
34%
-64
- C3 -
3J5S
-
ETTA_ECOLI
D:
[27-538]
--------------------------------------------------------------------------------------------
I
L
----
K
N
I
S
L
----
S
F
-
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
I
E
--
G
E
A
R
P
Q
P
--------------
D
--
I
K
I
--
G
Y
L
P
Q
E
P
Q
-
L
N
-
P
--
E
H
T
V
R
--
E
---
S
I
E
--
E
A
V
S
E
V
V
N
A
L
K
R
L
D
E
V
Y
A
---
L
Y
A
D
--
P
----
D
A
D
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
I
Q
A
H
D
G
H
N
L
N
V
----
Q
L
E
R
A
A
D
A
L
R
L
--
P
D
W
D
A
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
--
D
M
L
L
L
D
E
P
T
N
H
L
D
A
----
E
---
S
V
A
W
L
E
R
F
L
H
D
F
----
E
G
T
---
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
------
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
--
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
T
K
G
R
Q
S
K
G
K
A
R
L
A
R
F
E
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
F
I
P
P
G
------
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
--
D
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
---------------------
D
S
G
T
-------
I
T
L
G
E
T
V
-----------
K
L
A
S
V
D
---
Q
F
R
D
S
-
M
------------------------------------------------------------------------
D
--
N
S
K
T
V
W
E
E
V
S
G
------------------------------------------------------------------
G
-----------------------------------------
L
D
I
---
M
KIGN
T
--
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
V
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
---
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
----
E
F
----
P
G
C
----
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
------
D
--
E
G
K
V
E
F
F
E
G
N
F
T
E
Y
E
E
-------------------------------------------------------------------------------------------------------------------
44
HHSearch
76.98
29%
-90
- C- -
2IW3
7
EF3A_YEAST
A:
[439-979]
------------------------------------------------------------------------
C
E
F
S
L
A
Y
G
-
A
-------
K
-
I
L
L
----
N
K
T
Q
L
----
R
L
-
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
V
--
D
--
G
F
P
T
-
Q
E
--------------
E
--
C
R
T
--
V
Y
V
E
H
D
I
D
-
G
T
H
S
--
D
T
S
V
L
--
D
F
V
F
E
S
G
---------------------------------------------------------
V
G
T
K
E
----
A
I
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
----
V
---
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
T
---
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
-------
K
A
Y
E
E
-------
L
S
N
T
D
---------------------
L
E
---
F
K
F
P
E
----
P
-
G
Y
-
L
E
--
G
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
G
T
S
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
E
-------
V
Y
T
H
E
N
C
-----------
R
I
A
Y
I
K
---
Q
H
A
F
A
H
I
------------------------------------------------------------------------
E
SH
L
D
K
T
P
S
E
Y
I
Q
W
R
F
Q
TGEDRETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
NIGM
K
S
E
R
W
V
P
M
M
SVD
N
A
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
GQ
F
R
P
---
L
----
T
--
R
K
E
I
E
E
H
C
S
M
L
G
L
D
P
E
I
V
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
---
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
S
K
A
L
K
----
E
F
----
E
G
G
----
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
K
------
D
--
G
-
R
M
T
P
S
----------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
67.86
25%
-53
- C3 -
1YQT
4
?
A:
[44-472]
------------------------------------------------------------------------------------------------------------
V
-
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
----------------------------------------
P
N
-
L
C
-
G
--
D
N
D
S
W
--
D
G
V
I
R
A
F
RG
N
E
L
Q
N
Y
F
E
K
L
K
N
G
E
I
R
P
V
V
K
P
Q
Y
V
D
LI
P
----
K
A
-
V
K
G
K
V
I
E
---
L
L
K
K
A
D
E
T
G
----------
K
L
E
E
V
V
K
A
L
E
L
-
E
N
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
--
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
----
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
----
G
K
S
---
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
------
Y
G
E
P
-----
G
V
Y
G
I
F
S
Q
P
K
G
T
R
N
G
I
N
E
F
L
R
G
Y
L
K
D
E
N
V
-----
R
F
R
P
Y
E
I
-
K
F
T
K
T
G
E
R
V
E
I
E
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
G
S
-------
F
R
--
L
E
V
E
P
G
--------------------------
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
K
-------
I
E
W
D
L
T
V
-----------
A
---
Y
K
---
P
Q
Y
I
K
-
A
------------------------------------------------------------------------
D
--
Y
E
G
T
V
Y
E
L
L
S
K
I
-----------------------------------------------------------------
D
-----------------------------------------
A
S
K
---
L
----
N
--
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
----
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
63.41
20%
-28
- C3 -
3J16
4
RLI1_YEAST
B:
[1-608]
MS
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCRQ
E
C
K
R
S
C
P
V
V
K
T
GKLC
I
E
V
T
PTSK
I
A
F
I
S
EILCIGCG
I
C
V
K
K
CP
F
D
A
I
Q
I
I
N
L
P
T
N
L
E
-
A
-------
H
-
V
T
H
RYSA
N
S
F
K
L
H
R
L
P
T
P
-
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
L
--
G
R
F
D
D
P
P
--------------
E
--------------------------
W
--
Q
E
I
I
K
Y
F
RG
S
E
L
Q
N
Y
F
T
K
M
L
E
D
D
I
K
A
I
I
K
P
Q
Y
V
D
--
N
----
I
P
-
R
A
I
K
G
P
V
Q
K
V
G
E
L
L
K
L
R
M
--
E
K
S
P
E
----
D
V
K
R
Y
I
K
I
L
Q
L
-
E
N
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
--
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
----
K
---
Q
R
L
N
A
A
Q
I
I
R
S
L
----
L
A
P
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
------
Y
G
V
P
----------------------
S
V
Y
G
V
V
T
L
P
A
S
V
R
E
G
I
N
I
F
L
D
G
H
I
-
P
A
E
N
L
R
F
R
T
E
A
L
Q
F
R
I
A
D
A
T
E
D
L
Q
N
D
S
A
S
R
A
F
S
Y
P
-
S
--
L
K
K
T
Q
G
D
F
V
L
N
V
E
-----------------
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
---------------------
D
E
G
Q
-------
D
I
P
K
--
L
-----------
N
V
S
M
K
P
---
Q
K
I
A
P
-
K
------------------------------------------------------------------------
F
--
P
G
T
V
R
Q
L
F
F
K
K
------------------------------------------------------------------
I
-----------------------------------------
R
G
Q
---
F
----
L
--
N
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
----
R
F
----
I
L
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
-----------------------------------------
E
G
I
P
S
K
N
A
H
A
R
A
P
------------
E
S
L
L
T
G
C
N
R
F
L
K
N
L
N
V
T
F
R
R
-------------
D
P
N
S
F
R
P
R
I
N
K
L
D
S
Q
M
D
K
E
Q
K
S
S
G
N
Y
F
F
L
D
N
T
G
I
--------
4
PsiBlast_PDB
63.16
26%
-68
- C3 -
2IX3
6
EF3A_YEAST
A:
[440-744]
-------------------------------------------------------------------------
E
F
S
L
A
Y
G
-
A
-------
K
-
I
L
L
----
N
K
T
Q
L
----
R
L
-
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
--------
G
Q
V
D
-------------------------
G
F
P
T
Q
-----
E
-
E
--
C
R
T
V
Y
----------------
V
E
H
D
I
--------------------------
D
G
T
H
S
D
T
S
V
L
D
F
V
F
-
E
S
G
V
G
T
K
E
A
-----
I
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
----
V
---
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
T
---
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
--
K
K
C
P
--
A
A
K
A
Y
E
E
L
S
N
T
D
L
E
F
K
F
P
E
P
G
Y
L
E
G
V
----------
K
T
K
Q
K
A
I
V
K
V
------------
T
N
M
E
F
Q
--
Y
P
G
T
S
K
P
Q
I
------------------
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
E
-------
V
Y
T
H
E
N
C
-----------
R
I
A
Y
I
K
---
Q
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
62.92
26%
-73
- C3 -
2IWH
8
EF3A_YEAST
A:
[440-744]
-------------------------------------------------------------------------
E
F
S
L
A
Y
G
-
A
-------
K
-
I
L
L
----
N
K
T
Q
L
----
R
L
-
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
--------
G
Q
V
D
-------------------------
G
F
P
T
Q
-----
E
-
E
--
C
R
T
V
Y
----------------
V
E
H
D
I
--------------------------
D
G
T
H
S
D
T
S
V
L
D
F
V
F
-
E
S
G
V
G
T
K
E
A
-----
I
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
----
V
---
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
T
---
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
--
K
K
C
P
--
A
A
K
A
Y
E
E
L
S
N
T
D
L
E
F
K
F
P
E
P
G
Y
L
E
G
V
----------
K
T
K
Q
K
A
I
V
K
V
------------
T
N
M
E
F
Q
--
Y
P
G
T
S
K
P
Q
I
------------------
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
E
-------
V
Y
T
H
E
N
C
-----------
R
I
A
Y
I
K
---
Q
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
62.84
24%
-54
- C3 -
3BK7
2
?
A:
[114-543]
------------------------------------------------------------------------------------------------------------
V
-
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
--------------------------------
I
--
P
N
L
C
E
D
N
----------
D
S
W
--
D
N
V
I
R
A
F
RG
N
E
L
Q
N
Y
F
E
R
L
K
N
G
E
I
R
P
V
V
K
P
Q
Y
V
D
L
L
P
--------
K
A
V
K
G
K
V
R
E
L
L
K
K
V
D
E
V
G
K
F
E
E
V
V
----
K
E
L
E
L
E
N
V
L
-------
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
--
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
----
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
----
G
K
A
---
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
------
Y
G
E
P
-----
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
G
I
N
E
F
L
Q
G
Y
L
K
D
E
N
V
-----
R
F
R
P
Y
E
I
-
R
F
T
K
L
S
E
R
V
D
V
E
R
E
T
L
V
E
Y
P
R
L
V
K
D
Y
G
S
-------
F
K
--
L
E
V
E
P
G
--------------------------
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
K
-------
V
E
W
D
L
T
V
-----------
A
---
Y
K
---
P
Q
Y
I
K
-
A
------------------------------------------------------------------------
E
--
Y
E
G
T
V
Y
E
L
L
S
K
I
-----------------------------------------------------------------
D
-----------------------------------------
S
S
K
---
L
----
N
--
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
----
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.63
26%
-70
- C3 -
2IW3
6
EF3A_YEAST
A:
[440-744]
-------------------------------------------------------------------------
E
F
S
L
A
Y
G
-
A
-------
K
-
I
L
L
----
N
K
T
Q
L
----
R
L
-
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
--------
G
Q
V
D
-------------------------
G
F
P
T
Q
-----
E
-
E
--
C
R
T
V
Y
----------------
V
E
H
D
I
--------------------------
D
G
T
H
S
D
T
S
V
L
D
F
V
F
-
E
S
G
V
G
T
K
E
A
-----
I
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
--
D
I
L
L
L
D
E
P
T
N
H
L
D
T
----
V
---
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
T
---
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
------
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
--
K
K
C
P
--
A
A
K
A
Y
E
E
L
S
N
T
D
L
E
F
K
F
P
E
P
G
Y
L
E
G
V
----------
K
T
K
Q
K
A
I
V
K
V
------------
T
N
M
E
F
Q
--
Y
P
G
T
S
K
P
Q
I
------------------
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
---------------------
T
S
G
E
-------
V
Y
T
H
E
N
C
-----------
R
I
A
Y
I
K
---
Q
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
61.59
21%
-55
- C3 -
3J16
2
RLI1_YEAST
B:
[82-558]
-------------------------------------------------------------------------
H
V
T
H
R
Y
S
-
A
-------
N
S
F
K
L
----
H
R
L
P
-----
T
P
-
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
L
--
G
R
F
D
D
P
P
--------------
E
W
Q
E
I
I
--
K
Y
F
-
R
G
S
E
-
L
Q
-
N
Y
F
T
K
M
L
E
--
D
D
I
K
A
I
I
--
K
P
Q
Y
V
-----
D
N
I
P
R
A
I
-------------------
K
---
G
P
V
Q
K
V
G
E
L
L
K
-
L
R
M
E
K
S
P
E
----
D
V
K
R
Y
I
K
I
L
Q
L
E
N
-
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
--
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
----
K
---
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
-
T
K
Y
---
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
------
Y
G
V
P
S
V
-
Y
-
G
V
V
T
L
P
A
S
V
R
E
-----------------
G
I
---
N
I
F
L
D
G
H
I
-
P
A
E
----
N
L
R
F
R
---
T
E
A
L
Q
-
F
R
I
A
D
----
A
T
E
-
D
----
L
Q
N
D
S
A
S
R
A
F
S
Y
P
S
L
K
K
T
Q
G
---
D
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
---------------------
D
E
G
Q
-------
D
I
P
--
K
L
-----------
N
V
S
M
K
P
---
Q
K
I
A
P
-
K
---------------------------------------------------------------------------
F
P
G
T
V
R
Q
L
F
F
K
------------------------------------------------------------------
K
-----------------------------------------
I
R
G
QF-
L
----
N
--
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
-
D
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
----
R
F
I
L
H
N
K
K
T
----
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
------
G
I
P
S
-
K
N
A
H
-
A
R
A
P
E
S
L
L
--------------------------------------------------------------------------------------------------------------------
47
HHSearch
60.87
24%
-53
- C3 -
1YQT
4
?
A:
[25-480]
------------------------------------------------------------------------
E
D
C
V
H
R
Y
G
-
V
N------
A
-
F
V
L
----
Y
R
L
P
-----
V
V
-
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
CG
D
N
D
S
W
D
G
--------------
V
--
I
R
A
F
R
G
N
E
L
Q
N
Y
F
E
K
L
-
K
--
N
G
E
I
R
--
P
V
V
K
P
Q
Y
--
V
D
L
-------------
I
------
P
K
---------------
A
V
K
G
K
V
I
E
---
L
L
K
K
A
D
E
T
G
----
K
L
E
E
V
V
K
A
L
E
L
E
N
-
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
--
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
----
R
---
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
-
G
K
S
---
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
------
Y
G
E
P
-----
G
V
Y
G
I
F
S
Q
P
K
G
T
R
--
N
---------------
G
I
N
E
F
L
R
G
Y
L
-
K
D
---------
E
N
V
R
F
R
P
Y
E
-
I
K
F
T
K
T
-
G
E
R
V
---------
E
I
E
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
G
---
S
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
K
-------
I
E
W
D
L
-------------
T
V
A
Y
K
P
---
Q
Y
I
K
A
-
D
---------------------------------------------------------------------------
Y
E
G
T
V
Y
E
L
L
S
K
------------------------------------------------------------------
I
-----------------------------------------
D
A
S
K
L
-
N
----
S
--
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
-
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
----
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
------
G
--
E
-
P
G
-------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
60.43
24%
-44
- C3 -
3J15
2
?
B:
[100-529]
------------------------------------------------------------------------------------------------------------
V
-
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
----------------------------------------
P
N
-
L
C
-
E
--
D
N
D
S
W
--
D
N
V
I
R
A
F
RG
N
E
L
Q
N
Y
F
E
R
L
K
N
G
E
I
R
P
V
V
K
P
Q
Y
V
D
L
L
P
--------
K
A
V
K
G
K
V
R
E
L
L
K
K
V
D
E
V
G
K
F
E
E
V
V
----
K
E
L
E
L
E
N
V
L
-------
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
--
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
----
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
----
G
K
A
---
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
------
Y
G
E
P
-----
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
G
I
N
E
F
L
Q
G
Y
L
K
D
E
N
V
-----
R
F
R
P
Y
E
I
-
R
F
T
K
L
S
E
R
V
D
V
E
R
E
T
L
V
E
Y
P
R
L
V
K
D
Y
G
S
-------
F
K
--
L
E
V
E
P
G
--------------------------
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
K
-------
V
E
W
D
L
T
V
-----------
A
---
Y
K
---
P
Q
Y
I
K
-
A
------------------------------------------------------------------------
E
--
Y
E
G
T
V
-
Y
E
L
L
S
K
I
----------------------------------------------------------------
D
-----------------------------------------
S
S
K
---
L
----
N
--
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
----
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
59.79
23%
-62
- C3 -
3BK7
4
?
A:
[83-547]
--------------------------------------------------------------------
A
I
S
I
V
N
L
P
E
Q
L
D
-
E
D
CVHRYG
V
-
N
A
F
----
V
L
Y
R
L
----
P
I
V
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
--
C
E
D
N
D
S
W
--------------
D
---
N
V
--
I
R
A
F
R
G
N
E
-
L
Q
-
N
--
Y
F
E
R
L
K
N
G
E
I
R
P
V
V
--
K
P
Q
Y
---------------
V
D
L
L
P
K
-------------
A
--
V
K
G
K
V
R
E
L
L
---
K
K
V
D
E
V
G
----
K
F
E
E
V
V
K
E
L
E
L
E
N
-
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
--
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
----
R
---
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
-
G
K
A
---
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
------
Y
G
E
P
-----
G
V
Y
G
I
F
S
K
P
K
G
T
R
--
N
G
---------------
I
N
E
F
L
Q
G
Y
L
-
K
D
E
------
N
V
R
---
F
R
-------
P
Y
----
E
I
R
F
T
K
L
SE
R
V
D
V
E
R
E
T
L
V
E
Y
P
R
L
V
K
D
Y
G
---
S
F
K
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
---------------------
T
E
G
K
-------
V
E
W
D
--
L
-----------
T
V
A
Y
K
P
---
Q
Y
I
K
A
-
E
---------------------------------------------------------------------------
Y
E
G
T
V
Y
E
L
L
S
K
------------------------------------------------------------------
I
-----------------------------------------
D
S
S
K
L
-
N
----
S
--
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
-
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
----
H
L
M
E
K
N
E
K
T
----
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
------
G
-------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
58.54
21%
-67
- C3 -
3OZX
5
?
A:
[4-463]
-------------------------------------------------------------------------
E
V
I
H
R
Y
K
V
N
-------
G
-
F
K
L
----
F
G
L
P
T
-----
P
-
K
N
N
T
I
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
L
A
G
E
I
I
P
N
F
--
G
D
P
N
S
K
V
G
K
D
E
V
L
K
R
F
R----
G
--
K
E
I
--
Y
N
Y
F
K
E
L
Y
--
S
-
N
--
E
L
K
I
V
--
H
K
I
Q
Y
V
E
--
Y
A
-
S
-----------
K
F
-----
L
-------------------
K
G
T
V
N
E
I
L
---
T
K
I
D
E
R
G
----
K
K
D
E
V
K
E
L
L
N
M
T
N
-
L
W
N
K
D
A
N
I
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
A
--
D
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
----
R
---
E
R
M
N
M
A
K
A
I
R
E
L
L
K--
N
K
Y
---
V
I
V
V
D
H
D
L
I
V
L
D
Y
L
T
D
L
I
H
I
I
------
Y
-
G
E
S
S
V
Y
-
G
R
V
S
K
S
Y
A
A
R
V
-
G
--
I
N
----
N
F
---------
L
K
G
Y
L
P
A
E
N
-
M
K
I
----
R
P
D
E
I
K
F
M
L
K
---------------------------
L
K
T
K
M
K
W
T
K
I
I
K
K
L
G
---
D
F
Q
L
V
V
D
N
G
E
A
K
E
G
E
I
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
I
L
V
G
E
I
T
A
---------------------
D
E
G
S
-------
V
T
P
E
K
-
Q
-----------
I
L
S
Y
K
P
---
Q
R
I
F
P
--------------------------------------------------------------------------
N
--
Y
D
G
T
V
Q
Q
Y
L
E
N
------------------------------------------------------------------
A
-----------------------------------------
S
K
D
ALS
T
----
S
--
S
W
F
F
E
E
V
T
K
R
L
N
L
H
R
-
L
-
L
E
S
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
---
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
I
V
A
K
A
I
K
----
R
V
T
R
E
R
K
A
V
----
T
F
I
I
D
H
D
L
S
I
H
D
Y
I
A
D
R
I
I
V
F
K
------
G
--
E
-
P
--------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
57.11
23%
-57
- C3 -
3OZX
5
?
A:
[28-466]
-------------------------------------------------------------------------------------------------------------------
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
L
A
G
E
--------------------------------------
I
I
P
N
F
G
-
D
P
-
N
--
S
K
V
G
K
--
D
E
V
L
K
R
F
------------
R
G
K
E
I
Y
N
Y
F
K
E
L
Y
S
N
--
E
L
K
I
V
H
K
-
I
Q
Y
V
E
Y
A
S
K
F
L
K
G
T
V
N
E
I
L
T
K
I
D
E
R
GK
K
D
E
V
K
E
L
L
N
M
T
N
L
W
N
K
D
A
N
I
----
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
A
--
D
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
R
E
R
M
N
---
M
A
K
A
I
R
E
L
L
K
N
K
----
Y
-----
V
I
V
V
D
H
D
L
I
V
L
D
Y
L
T
D
L
I
H
I
I
-----------------
Y
G
E
-----------
S
S
V
Y
G
R
V
S
K
S
Y
A
A
R
V
G
I
N
N
F
L
K
G
Y
L
-
P
A
E
N
M
K
I
R
P
D
E
I
K
F
M
L
K
-----------
L
K
T
K
M
K
W
T
K
--
I
I
K
K
L
G
D
F
Q
L
V
V
D
N
---
G
E
A
K
-
E
G
E
I
-------------
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
I
L
V
G
E
I
T
A
---------------------
D
E
G
S
V
T
PEKQI
L
S
Y
K
P
Q
R
-----------
I
F
P
N
Y
D
GT
V
Q
Q
Y
L
E
-
N
------------------------------------------------------------------------
A
--
S
K
D
A
L
S
T
S
S
W
---------------------------------------------------------------------------------------------------------------
F
---
F
----
E
--
E
V
T
K
R
L
N
L
H
R
L
L
E
S
-------
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
---
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
I
V
A
K
A
I
K
R
V
T
R
E
R
----
K
A
V
----
T
F
I
I
D
H
D
L
S
I
H
D
Y
I
A
D
R
I
I
V
F
K
G
E
----
P
--
E
-
K
A
-------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
55.36
22%
-50
- C3 -
2R6F
3
?
A:
[487-943]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
TG
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
----
R
---
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L-
G
N
T
---
L
I
V
V
E
H
D
E
D
T
M
L
-
A
A
D
Y
L
I
D
I
G
PGAGI
H
G
G
E
V
V
A
A
-
G
T
P
E
E
V
M
N
D
P
N
S
L
--
T
-----------------
G
Q
Y
L
S
G
----------------
K
K
F
I
-----
P
I
P
A
-------------
E
R
R
R
P
D
G
R
W
L
E
V
V
G
A
R
-------
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
LHRAK
A
K
P
G
EHRDIRGLEH
L
D
K
V
-------
I
D
I
D
Q
S
P
IGRTPRSN
P
A
T
Y
T
G
V
F
D
---
D
I
R
D
V
-
F
A
S
T
N
E
A
K
V
R
GYKKGRFSFNVKGGRCEACHGDG
I
I
K
I
E
M
H
FL
P
D
V
Y
V
P
CEVCHGKRYNRETLEVTYKGKN
I
A
E
V
--
L
D
M
T
V
E
D
A
L
D
F
------------------------------------------------------------------
F
-----------------------------------------
A
S
I
---
P
----
K
--
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
-
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
NGR
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
----
R
L
V
D
N
-
G
D
T
----
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
PEGGDR
G
--
G
-
Q
I
V
-
A
V
G
T
P
E
E
V
A
E
V
------------------------------------------------------------------------------------------------------------------
53
HHSearch
53.84
26%
-90
* C3 *
1OXX
21
?
K:
[1-228]
------------------------------------------------------------------
M
V
R
I
I
V
K
N
V
S
K
V
F
K
-
K
GK-----
V
-
V
A
L
----
D
N
V
N
I
----
N
I
-
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
--
G
E
L
Y
F
D
D
RLVASNGKLIVPPE
D
--
R
K
I
--
G
M
V
F
Q
T
W
A
-
L
Y
-
P
--
N
L
T
A
F
--
E
N
I
A
F
P
L
--
T
N
M
K
------------------------------------------------
M
S
K
E
E
I
R
K
----
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
--
S
L
L
L
L
D
E
P
F
S
N
L
D
A
----
R
---
M
R
D
S
A
R
A
L
V
K
E
V
QSRL
G
V
T
---
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
------
V
K
G
K
L
V
Q
V
-
G
K
P
E
D
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
53.36
23%
-95
- C3 -
3RLF
3
MALK_ECOLI
A:
[2-221]
-------------------------------------------------------------------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
-
E
-------
V
-
V
V
S
----
K
D
I
N
L
----
D
I
-
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
--
G
D
L
F
I
G
E
KRMNDTPPA-----
E
--
R
G
V
--
G
M
V
F
Q
S
Y
A
-
L
Y
-
P
--
H
L
S
V
A
--
E
N
M
S
F
G
L
--
K
L
A
G
------------------------------------------------
A
K
K
E
V
I
N
Q
----
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
--
S
V
F
L
L
D
E
P
L
S
N
L
D
A
----
A
---
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
---
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
------
D
A
G
R
V
A
Q
V
-
G
K
P
L
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
53.36
23%
-90
- C3 -
3TUI
1
METN_ECOLI
C:
[23-252]
-------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
-
Q
GTRT---
I
-
Q
A
L
----
N
N
V
S
L
----
H
V
-
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
--
G
S
V
L
V
D
G
QELTTLSESELTKA
R
--
R
Q
I
--
G
M
I
F
Q
H
F
N
-
L
L
-
S
--
S
R
T
V
F
--
G
N
V
A
L
P
L
--
E
L
D
N
------------------------------------------------
T
P
K
D
E
V
K
R
----
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
--
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
----
A
---
T
T
R
S
I
L
E
L
L
K
D
I
NRRL
G
L
T
---
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
------
S
N
G
E
L
I
E
Q
-
D
T
V
S
E
V
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
53.21
23%
-85
- C3 -
1Z47
1
?
A:
[13-234]
-------------------------------------------------------------------
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
-------
A
-
R
S
V
----
R
G
V
S
F
----
Q
I
-
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
--
G
D
V
W
I
G
G
KRVTDLPPQ-----
K
--
R
N
V
--
G
L
V
F
Q
N
Y
A
-
L
F
-
Q
--
H
M
T
V
Y
--
D
N
V
S
F
G
L
--
R
E
K
R
------------------------------------------------
V
P
K
D
E
M
D
A
----
R
V
R
E
L
L
R
F
M
R
L
E
S
-
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
--
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
----
Q
---
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
---
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
------
H
E
G
N
V
E
Q
F
-
G
T
P
E
E
V
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------