@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2252: (2016-04-02 )
MNHSKIAKKHQQMPVNILADIGTLAKTMPDILDLSIGDPDLITDESIINAAFEDVRAGHTKYTESGGDVELIDAIRGYFSRNYDLSFERSQIRATVGALHGMYLTLQTILDDGDEVIIHEPYFSPYKDQVLNSGGTPIIIPTYEKDDFAINVDILEAAITDKTKALILNSPNNPTGAVFSPETFEKIANLAKKYDFFILSDEVYDGFSFYEDFVPMAKFAPDHTITFGSMSKNFAMTGWRLGYMIAPTYLNEAAKIINEGITYSAPTPSQRAAIYALNHSETLIPLVAETFQKRLEYIAKRVEKIPYLSLHPLKGSIYAFINISKTNMDSVSFTEYVLKETQVLVIPGLAFGESGDNYVRLAATQDISVLEEAFNRLAKLTF
Atome Classification :
(28 SA)
.........10..--......20....---.-.----.----.----30........---40--.........50.......-.60........70........80.......--.90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.--.......---220.---.----.......230.......240..--...-.-.----250.......--260.......---270......--.280-.---........290.......300.......310.......320.......-..330.......340.......350.......360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
H
S
K
I
A
K
K
H
QQM--
P
V
N
I
L
A
D
I
G
T
L
A
---
K
-
T
----
M
----
P
----
D
I
LDLSIGDP---D---LI
T
D
E
S
I
I
N
A
A
F
E
D
V
RAG-HTKYTESGG
D
V
E
L
I
D
A
I
R
G
Y
F
SRNYDLS
F
E
--
R
S
Q
I
R
A
T
V
G
A
L
H
G
M
Y
L
T
L
Q
T
I
LDDGD
E
V
I
I
HEPYFS
P
Y
K
D
Q
V
LNSGG
T
P
I
I
I
P
TYEKD
D
F
A
I
N
V
D
I
L
E
A
A
ITDK
T
K
A
L
I
L
NSPNNPTGAVF
S
P
E
T
F
E
K
I
A
N
L
A
K
KY
D
F
F
I
L
SDEVYD
G
F
S
F
Y
E
-
D
--
F
V
P
M
A
KF---A--P---D----
H
T
I
T
FGSMSKNFAMTG
W
R
L
G
Y
M
--I
A
P
-
T
-
Y
----
L
N
E
A
A
K
I
I
NE--GITYSAPTPS---Q
R
A
A
I
Y
A
LN--HS---E---
T
L
I
P
L
V
A
E
T
F
Q
K
R
L
E
Y
I
A
K
R
V
E
KIP
Y
L
S
L
HPLKG
S
I
Y
A
F
--
I
N
I
SKTN-MDS
V
S
F
T
E
Y
V
L
KET
Q
V
L
V
I
PGLAFGESGD
N
Y
V
R
L
AATQ
D
I
S
V
L
E
E
A
F
N
R
L
A
KLTF
54
HHSearch
95.43
34%
-100
- C1 -
1GD9
2
?
A:
[2-383]
----
A
L
S
D
R
L
E
L
V
--
S
A
S
E
I
R
K
L
F
D
I
A
---
A
-
G
----
M
----
K
----
D
V
I
S
L
G
I
G
E
P
---
D
---
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
T
-
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
PK
T
-
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
--
H
Y
S
I
A
S
L
---
D
GM
F
---
E
----
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
--
A
A
P
-
S
-
W
----
I
I
E
R
M
V
K
F
Q
M
--
Y
N
A
T
C
P
V
T
F
I
---
Q
Y
A
A
A
K
A
L
K
--
D
E
R
S
-
W
---
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
--
P
R
I
R
D
T
G
-
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
-
2
PsiBlast_PDB
91.96
36%
-99
- C1 -
1GD9
2
?
A:
[21-382]
-------------------------
I
A
---
A
-
G
----
M
----
K
----
D
V
I
S
L
G
I
G
E
P
---
D
---
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
-
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P-
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
-
I
Y
D
-
D
--
A
R
H
Y
S
I
A
---
S
--
L
---
D
GMFE
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
--
A
A
P
-
S
-
W
----
I
I
E
R
M
V
K
F
Q
-----
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
D
E
R
S
---
W
---
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
-
K
G
A
F
Y
I
F
--
P
R
I
R
D
T
G
-
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
--
22
PsiBlast_CBE
91.47
36%
-98
- C1 -
1GD9
2
?
B:
[21-382]
-------------------------
I
A
---
A
-
G
----
M
----
K
----
D
V
I
S
L
G
I
G
E
P
---
D
---
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
-
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P-
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
-
I
Y
D
-
D
--
A
R
H
Y
S
I
A
---
S
--
L
---
D
GMFE
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
--
A
A
P
-
S
-
W
----
I
I
E
R
M
V
K
F
Q
-----
M
Y
N
A
T
C
P
V
TFI
Q
Y
A
A
A
K
A
L
K
DE
R
S
---
W
---
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
-
K
G
A
F
Y
I
F
--
P
R
I
R
D
T
G
-
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
--
21
PsiBlast_CBE
91.42
36%
-96
- C1 -
1GDE
4
?
B:
[21-382]
-------------------------
I
A
---
A
-
G
----
M
----
K
----
D
V
I
S
L
G
I
G
E
P
---
D
---
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
-
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P-
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
-
I
Y
D
-
D
--
A
R
H
Y
S
I
A
---
S
--
L
---
D
GMFE
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
--
A
A
P
-
S
-
W
----
I
I
E
R
M
V
K
F
Q
-----
M
Y
N
A
T
C
P
V
TFI
Q
Y
A
A
A
K
A
L
K
DE
R
S
---
W
---
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
-
K
G
A
F
Y
I
F
--
P
R
I
R
D
T
G
-
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
--
1
PsiBlast_PDB
91.40
36%
-97
- C1 -
1GDE
4
?
A:
[21-382]
-------------------------
I
A
---
A
-
G
----
M
----
K
----
D
V
I
S
L
G
I
G
E
P
---
D
---
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
-
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P-
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
-
I
Y
D
-
D
--
A
R
H
Y
S
I
A
---
S
--
L
---
D
GMFE
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
--
A
A
P
-
S
-
W
----
I
I
E
R
M
V
K
F
Q
-----
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
D
E
R
S
---
W
---
K
A
V
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
G
L
P
T
V
K
P
-
K
G
A
F
Y
I
F
--
P
R
I
R
D
T
G
-
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
--
46
PsiBlast_CBE
90.22
32%
-103
- C1 -
1XI9
2
?
B:
[33-399]
-------------------------
L
E
---
K
-
K
----
G
----
I
----
K
V
I
R
L
N
I
G
D
P
VKF
D
---
F
Q
P
P
E
H
M
K
E
A
Y
C
K
A
I
K
E
G
-
H
N
Y
Y
G
D
S
E
G
L
P
E
L
R
K
A
I
V
E
R
E
K
R
K
N
G
V
D
I
T
--
P
D
D
V
R
V
T
A
A
V
T
E
A
L
Q
L
I
F
G
A
L
L
D
P
G
D
E
I
L
V
P
G
P
S
Y
P
P
Y
T
G
L
V
K
F
Y
G
G
K
P
V
E
Y
R
T
I
E
E
E
D
W
Q
P
D
I
D
D
I
R
K
K
I
T
D
R
T
K
A
I
A
V
I
N
P
N
N
P
T
G
A
L
Y
D
K
K
T
L
E
E
I
L
N
I
A
G
E
Y
E
I
P
V
I
S
D
E
I
Y
D
L
M
T
Y
E
G
-
E
--
H
I
S
P
G
S
L
---
T
--
K
---
D
V
---
P
V
I
V
M
N
G
L
S
K
V
Y
F
A
T
G
W
R
L
G
Y
M
Y
F
V
D
P
E
N
-
K
----
L
S
E
V
R
E
A
I
D
R
L
A
R
I
R
L
C
P
N
T
P
A
---
Q
F
A
A
I
A
G
L
T
--
G
P
---
M
---
D
Y
L
K
E
Y
M
K
K
L
K
E
R
R
D
Y
I
Y
K
R
L
N
E
I
P
G
I
S
T
T
K
P
Q
G
A
F
Y
I
F
P
K
I
E
V
G
P
W
K
-
N
D
K
-
E
F
V
L
D
V
L
H
N
A
H
V
L
F
V
H
G
S
G
F
G
E
Y
G
A
G
H
F
R
A
V
F
L
P
P
I
E
I
L
E
E
A
M
D
R
F
E
K
F
--
45
PsiBlast_CBE
90.20
32%
-99
- C1 -
1XI9
2
?
C:
[33-399]
-------------------------
L
E
---
K
-
K
----
G
----
I
----
K
V
I
R
L
N
I
G
D
P
VKF
D
---
F
Q
P
P
E
H
M
K
E
A
Y
C
K
A
I
K
E
G
-
H
N
Y
Y
G
D
S
E
G
L
P
E
L
R
K
A
I
V
E
R
E
K
R
K
N
G
V
D
I
T
--
P
D
D
V
R
V
T
A
A
V
T
E
A
L
Q
L
I
F
G
A
L
L
D
P
G
D
E
I
L
V
P
G
P
S
Y
P
P
Y
T
G
L
V
K
F
Y
G
G
K
P
V
E
Y
R
T
I
E
E
E
D
W
Q
P
D
I
D
D
I
R
K
K
I
T
D
R
T
K
A
I
A
V
I
N
P
N
N
P
T
G
A
L
Y
D
K
K
T
L
E
E
I
L
N
I
A
G
E
Y
E
I
P
V
I
S
D
E
I
Y
D
L
M
T
Y
E
G
-
E
--
H
I
S
P
G
S
L
---
T
--
K
---
D
V
---
P
V
I
V
M
N
G
L
S
K
V
Y
F
A
T
G
W
R
L
G
Y
M
Y
F
V
D
P
E
N
-
K
----
L
S
E
V
R
E
A
I
D
R
L
A
R
I
R
L
C
P
N
T
P
A
---
Q
F
A
A
I
A
G
L
T
--
G
P
---
M
---
D
Y
L
K
E
Y
M
K
K
L
K
E
R
R
D
Y
I
Y
K
R
L
N
E
I
P
G
I
S
T
T
K
P
Q
G
A
F
Y
I
F
P
K
I
E
V
G
P
W
K
-
N
D
K
-
E
F
V
L
D
V
L
H
N
A
H
V
L
F
V
H
G
S
G
F
G
E
Y
G
A
G
H
F
R
A
V
F
L
P
P
I
E
I
L
E
E
A
M
D
R
F
E
K
F
--
44
PsiBlast_CBE
89.32
32%
-100
* C1 *
1XI9
2
?
D:
[33-399]
-------------------------
L
E
---
K
-
K
----
G
----
I
----
K
V
I
R
L
N
I
G
D
P
VKF
D
---
F
Q
P
P
E
H
M
K
E
A
Y
C
K
A
I
K
E
G
-
H
N
Y
Y
G
D
S
E
G
L
P
E
L
R
K
A
I
V
E
R
E
K
R
K
N
G
V
D
I
T
--
P
D
D
V
R
V
T
A
A
V
T
E
A
L
Q
L
I
F
G
A
L
L
D
P
G
D
E
I
L
V
P
G
P
S
Y
P
P
Y
T
G
L
V
K
F
Y
G
G
K
P
V
E
Y
R
T
I
E
E
E
D
W
Q
P
D
I
D
D
I
R
K
K
I
T
D
R
T
K
A
I
A
V
I
N
P
N
N
P
T
G
A
L
Y
D
K
K
T
L
E
E
I
L
N
I
A
G
E
Y
E
I
P
V
I
S
D
E
I
Y
D
L
M
T
Y
E
G
-
E
--
H
I
S
P
G
S
L
---
T
--
K
---
D
V---
P
V
I
V
M
N
G
L
S
K
V
Y
F
A
T
G
W
R
L
G
Y
M
YF
V
D
P
E
N
-
K
----
L
S
E
V
R
E
A
I
D
R
LA
R
I
R
L
C
P
N
T
P
A
---
Q
F
A
A
I
A
G
L
T
--
G
P
---
M
---
D
Y
L
K
E
Y
M
K
K
L
K
E
R
R
D
Y
I
Y
K
R
L
N
E
I
P
G
I
S
T
T
K
P
Q
G
A
F
Y
I
F
PK
I
E
V
G
P
W
K
-
N
D
K
-
E
F
V
L
D
V
L
H
N
A
H
V
L
F
V
H
G
S
G
F
G
E
Y
G
A
G
H
F
R
A
V
F
L
P
P
I
E
I
L
E
E
A
M
D
R
F
E
K
F
--
57
HHSearch
88.79
32%
-97
- C1 -
1O4S
8
AAT_THEMA
A:
[14-386]
-----
V
S
R
R
I
S
E
I
--
P
I
S
K
T
M
E
L
D
A
K
A
---
K
-
A
L
I
K
K
G
----
E
----
D
V
I
N
L
T
A
G
E
P
---
D
---
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
G
E
V
-
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
S
P-
D
-
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
G
G
T
V
N
V
V
E
T
F
M
S
K
N
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
D
-
E
--
F
T
S
I
L
D
V
S--
E
G-
F
---
D
----
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
--
I
S
S
-
E
-
K
----
V
A
T
A
V
S
K
I
Q
S
--
H
T
T
S
C
I
N
T
V
A
---
Q
Y
A
A
L
K
A
L
E
--
V
D
---------
N
S
Y
M
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
--
F
K
V
R
G
----
D
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
--
P
G
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
-
13
PsiBlast_PDB
88.79
30%
-94
- C1 -
1J32
2
?
A:
[2-383]
----
K
L
A
A
R
V
E
S
V
--
S
P
S
M
T
L
I
I
D
A
K
A
---
K
-
A
----
M
----
K
A
E
GI
D
V
C
S
F
S
A
G
E
P
---
D
---
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
G
-
K
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
G
--
A
D
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
T
P
V
I
L
P
T
T
V
E
T
Q
F
K
V
S
P
E
Q
I
R
Q
A
I
T
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
-
L
Y
D
-
D
A
Q
H
L
S
I
G
A
A
---
S
--
P
E
A
Y
E
----
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
--
A
G
P
-
V
-
P
----
L
V
K
A
A
T
K
I
Q
G
--
H
S
T
S
N
V
C
T
F
A
---
Q
Y
G
A
I
A
A
Y
E
--
N
S
---
Q
---
D
C
V
Q
E
M
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
--
P
S
I
A
K
T
G
-
R
S
S
L
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
G
--
A
D
D
C
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
--
26
PsiBlast_CBE
88.03
31%
-95
- C1 -
1O4S
4
AAT_THEMA
B:
[14-382]
-----
V
S
R
R
I
S
E
I
--
P
I
S
K
T
M
E
L
D
A
K
A
---
K
-
A
----
L
I
K
K
G
E
----
D
V
I
N
L
T
A
G
E
P
---
D
---
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
G
-
E
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
S
--
P
D
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
G
G
T
V
N
V
V
E
T
F
M
S
K
N
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
D
-
E
--
F
T
S
I
L
D
V
---
S
--
E
GF-
D
----
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
--
I
S
S
-
E
-
K
----
V
A
T
A
V
S
K
I
Q
S
--
H
T
T
S
C
I
N
T
V
A
---
Q
Y
A
A
L
K
A
L
E
--
V
D
---
N
---
S
Y
M
---
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
G
V
K
F
V
E
P
-
E
G
A
F
Y
L
F
--
F
---
K
V
R
-
G
D
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
P
G
--
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
-----
15
PsiBlast_PDB
87.37
32%
-98
- C1 -
1XI9
2
?
A:
[33-399]
-------------------------
L
E
---
K
-
K
----
G
----
I
----
K
V
I
R
L
N
I
G
D
P
VKF
D
---
F
Q
P
P
E
H
M
K
E
A
Y
C
K
A
I
K
E
G
-
H
N
Y
Y
G
D
S
E
G
L
P
E
L
R
K
A
I
V
E
R
E
K
R
K
N
G
V
D
I
T
--
P
D
D
V
R
V
T
A
A
V
T
E
A
L
Q
L
I
F
G
A
L
L
D
P
G
D
E
I
L
V
P
G
P
S
Y
P
P
Y
T
G
L
V
K
F
Y
G
G
K
P
V
E
Y
R
T
I
E
E
E
D
W
Q
P
D
I
D
D
I
R
K
K
I
T
D
R
T
K
A
I
A
V
I
N
P
N
N
P
T
G
A
L
Y
D
K
K
T
L
E
E
I
L
N
I
A
G
E
Y
E
I
P
V
I
S
D
E
I
Y
D
L
M
T
Y
E
G
-
E
--
H
I
S
P
G
S
L
---
T
--
K
---
D
V
---
P
V
I
V
M
N
G
L
S
K
V
Y
F
A
T
G
W
R
L
G
Y
M
Y
F
V
D
P
E
N
-
K
----
L
S
E
V
R
E
A
I
D
R
L
A
R
I
R
L
C
P
N
T
P
A
---
Q
F
A
A
I
A
G
L
T
--
G
P
---
M
---
D
Y
L
K
E
Y
M
K
K
L
K
E
R
R
D
Y
I
Y
K
R
L
N
E
I
P
G
I
S
T
T
K
P
Q
G
A
F
Y
I
F
P
K
I
E
V
G
P
W
K
-
N
D
K
-
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F
V
L
D
V
L
H
N
A
H
V
L
F
V
H
G
S
G
F
G
E
Y
G
A
G
H
F
R
A
V
F
L
P
P
I
E
I
L
E
E
A
M
D
R
F
E
K
F
--
55
HHSearch
86.34
30%
-92
- C1 -
1J32
2
?
A:
[2-384]
----
K
L
A
A
R
V
E
S
V
--
S
P
S
M
T
L
I
I
D
A
K
A
K
A
M
K
A
E
----
G
----
I
----
D
V
C
S
F
S
A
G
E
P
---
D
---
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
G
K
T
-
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
G
A-
D
-
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
T
P
V
I
L
P
T
T
V
E
T
Q
F
K
V
S
P
E
Q
I
R
Q
A
I
T
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
D
D
A
Q
--
H
L
S
I
G
A
A
S
P
E
A
--
Y
---
E
----
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
--
A
G
P
-
V
-
P
----
L
V
K
A
A
T
K
I
Q
G
--
H
S
T
S
N
V
C
T
F
A
---
Q
Y
G
A
I
A
A
Y
E
--
N
S
---
Q
---
D
C
V
Q
E
M
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
--
P
S
I
A
K
T
G
-
R
S
S
L
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
G
A
--
D
D
C
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
-
70
HHSearch
86.25
31%
-97
- C1 -
1XI9
2
?
A:
[34-400]
--------------------------
E
---
K
-
K
----
G
----
I
----
K
V
I
R
L
N
I
G
D
P
---
V
KFD
F
Q
P
P
E
H
M
K
E
A
Y
C
K
A
I
K
E
G
H
N
-
Y
Y
G
D
S
E
G
L
P
E
L
R
K
A
I
V
E
R
E
K
R
K
N
G
V
D
I
T
P-
D
-
D
V
R
V
T
A
A
V
T
E
A
L
Q
L
I
F
G
A
L
L
D
P
G
D
E
I
L
V
P
G
P
S
Y
P
P
Y
T
G
L
V
K
F
Y
G
G
K
P
V
E
Y
R
T
I
E
E
E
D
W
Q
P
D
I
D
D
I
R
K
K
I
T
D
R
T
K
A
I
A
V
I
N
P
N
N
P
T
G
A
L
Y
D
K
K
T
L
E
E
I
L
N
I
A
G
E
Y
E
I
P
V
I
S
D
E
I
Y
D
L
M
T
Y
E
G
-
E
--
H
I
S
P
G
S
L
---
T
K-
D
---
V
----
P
V
I
V
M
N
G
L
S
K
V
Y
F
A
T
G
W
R
L
G
Y
M
--
Y
F
V
D
P
E
N
KL
S
E
V
R
E
A
I
D
R
L
A
---
R
I
R
L
C
P
N
T
P
A
---
Q
F
A
A
I
A
G
L
T
--
G
P
---
M
---
D
Y
L
K
E
Y
M
K
K
L
K
E
R
R
D
Y
I
Y
K
R
L
N
E
I
P
G
I
S
T
T
K
P
Q
G
A
F
Y
I
F
--
P
K
I
E
V
G
P
W
K
N
D
K
E
F
V
L
D
V
L
H
N
A
H
V
L
F
V
H
G
S
G
F
G
E
Y
G
A
G
H
F
R
A
V
F
L
P
P
I
E
I
L
E
E
A
M
D
R
F
E
K
F
M
-
4
PsiBlast_PDB
86.07
31%
-92
- C1 -
1O4S
8
AAT_THEMA
A:
[14-382]
-----
V
S
R
R
I
S
E
I
--
P
I
S
K
T
M
E
L
D
A
K
A
---
K
-
A
----
L
I
K
K
G
E
----
D
V
I
N
L
T
A
G
E
P
---
D
---
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
G
-
E
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
S
--
P
D
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
G
G
T
V
N
V
V
E
T
F
M
S
K
N
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
D
-
E
--
F
T
S
I
L
D
V
---
S
--
E
GF-
D
----
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
--
I
S
S
-
E
-
K
----
V
A
T
A
V
S
K
I
Q
S
--
H
T
T
S
C
I
N
T
V
A
---
Q
Y
A
A
L
K
A
L
E
--
V
D
---
N
---
S
Y
M
---
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
G
V
K
F
V
E
P
-
E
G
A
F
Y
L
F
--
F
---
K
V
R
-
G
D
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
P
G
--
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
-----
33
PsiBlast_CBE
85.96
33%
-90
- C1 -
1GC4
4
AAT_THET8
D:
[32-381]
-----------------------------------------------
D
L
V
A
L
T
A
G
E
P
---
D
---
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
--
P
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
--
H
F
S
P
G
R
V
---
A
--
P
---
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
--
C
G
P
-
K
-
E
----
V
I
K
A
M
A
S
V
S
R
--
Q
S
T
T
S
P
D
T
I
A
---
Q
W
A
T
L
E
A
L
T
--
N
Q
---
E
ASR
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
-
S
G
A
F
Y
V
L
--
M
D
T
S
P
I
A
-
P
D
E
V
R
A
A
E
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
G
--
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
--
36
PsiBlast_CBE
85.92
33%
-92
- C1 -
1GC3
4
AAT_THET8
H:
[32-381]
-----------------------------------------------
D
L
V
A
L
T
A
G
E
P
---
D
---
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
--
P
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
--
H
F
S
P
G
R
V
---
A
--
P
---
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
--
C
G
P
-
K
-
E
----
V
I
K
A
M
A
S
V
S
R
--
Q
S
T
T
S
P
D
T
I
A
---
Q
W
A
T
L
E
A
L
T
--
N
Q
---
E
ASR
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
-
S
G
A
F
Y
V
L
--
M
D
T
S
P
I
A
-
P
D
E
V
R
A
A
E
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
G
--
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
--
23
PsiBlast_CBE
85.89
32%
-90
- C1 -
5BJ3
2
AAT_THET8
D:
[4-381]
-----
L
S
R
R
V
Q
A
M
KP---------------------------------
L
V
A
L
T
A
G
E
P
---
D
---
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
--
P
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
--
H
F
S
P
G
R
V
---
A
--
P
---
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
--
C
G
P
-
K
-
E
----
V
I
K
A
M
A
S
V
S
R
--
Q
S
T
T
S
P
D
T
I
A
---
Q
W
A
T
L
E
A
L
T
--
N
Q
---
E
ASR
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
-
S
G
A
F
Y
V
L
--
M
D
T
S
P
I
A
-
P
D
E
V
R
A
A
E
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
G
--
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
--
25
PsiBlast_CBE
85.72
32%
-90
- C1 -
5BJ3
2
AAT_THET8
B:
[4-381]
-----
L
S
R
R
V
Q
A
M
KP---------------------------------
L
V
A
L
T
A
G
E
P
---
D
---
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
--
P
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
--
H
F
S
P
G
R
V
---
A
--
P
---
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
--
C
G
P
-
K
-
E
----
V
I
K
A
M
A
S
V
S
R
--
Q
S
T
T
S
P
D
T
I
A
---
Q
W
A
T
L
E
A
L
T
--
N
Q
---
E
ASR
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
-
S
G
A
F
Y
V
L
--
M
D
T
S
P
I
A
-
P
D
E
V
R
A
A
E
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
G
--
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
--
5
PsiBlast_PDB
85.72
33%
-90
- C1 -
1GCK
4
AAT_THET8
A:
[32-381]
-----------------------------------------------
D
L
V
A
L
T
A
G
E
P
---
D
---
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
--
P
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
--
H
F
S
P
G
R
V
---
A
--
P
---
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
--
C
G
P
-
K
-
E
----
V
I
K
A
M
A
S
V
S
R
--
Q
S
T
T
S
P
D
T
I
A
---
Q
W
A
T
L
E
A
L
T
--
N
Q
---
E
A
S
R
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
-
S
G
A
F
Y
V
L
--
M
D
T
S
P
I
A
-
P
D
E
V
R
A
A
E
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
G
--
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
--
11
PsiBlast_PDB
85.07
33%
-90
- C1 -
1B5O
3
AAT_THET8
A:
[32-381]
-----------------------------------------------
D
L
V
A
L
T
A
G
E
P
---
D
---
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
--
P
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
--
H
F
S
P
G
R
V
---
A
--
P
---
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
--
C
G
P
-
K
-
E
----
V
I
K
A
M
A
S
V
S
S
--
Q
S
T
T
S
P
D
T
I
A
---
Q
W
A
T
L
E
A
L
T
--
N
Q
---
E
A
S
R
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
-
S
G
A
F
Y
V
L
--
M
D
T
S
P
I
A
-
P
D
E
V
R
A
A
E
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
G
--
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
--
56
HHSearch
84.98
32%
-90
- C1 -
1B5P
3
AAT_THET8
A:
[4-382]
-----
L
S
R
R
V
Q
A
M
--
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
----
G
----
V
----
D
L
V
A
L
T
A
G
E
P
---
D
---
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
-
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P-
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
--
H
F
S
P
G
R
V
---
A
--
P
---
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
--
C
G
P
-
K
-
E
----
V
I
K
A
M
A
S
V
S
R
--
Q
S
T
T
S
P
D
T
I
A
---
Q
W
A
T
L
E
A
L
T
--
N
Q
E
A
S
R
---
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
--
M
D
T
S
P
I
A
-
P
D
E
V
R
A
A
E
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-
27
PsiBlast_CBE
84.67
33%
-90
- C1 -
1GCK
4
AAT_THET8
B:
[32-381]
-----------------------------------------------
D
L
V
A
L
T
A
G
E
P
---
D
---
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
--
P
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
--
H
F
S
P
G
R
V
---
A
--
P
---
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
--
C
G
P
-
K
-
E
----
V
I
K
A
M
A
S
V
S
R
--
Q
S
T
T
S
P
D
T
I
A
---
Q
W
A
T
L
E
A
L
T
--
N
Q
---
E
ASR
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
-
S
G
A
F
Y
V
L
--
M
D
T
S
P
I
A
-
P
D
E
V
R
A
A
E
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
G
--
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
--
28
PsiBlast_CBE
84.51
33%
-90
- C1 -
1B5P
3
AAT_THET8
B:
[32-381]
-----------------------------------------------
D
L
V
A
L
T
A
G
E
P
---
D
---
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
--
P
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
--
H
F
S
P
G
R
V
---
A
--
P
---
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
--
C
G
P
-
K
-
E
----
V
I
K
A
M
A
S
V
S
R
--
Q
S
T
T
S
P
D
T
I
A
---
Q
W
A
T
L
E
A
L
T
--
N
Q
---
E
ASR
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
-
S
G
A
F
Y
V
L
--
M
D
T
S
P
I
A
-
P
D
E
V
R
A
A
E
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
G
--
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
--
6
PsiBlast_PDB
84.38
33%
-89
- C1 -
1B5P
3
AAT_THET8
A:
[32-381]
-----------------------------------------------
D
L
V
A
L
T
A
G
E
P
---
D
---
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
--
P
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
--
H
F
S
P
G
R
V
---
A
--
P
---
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
--
C
G
P
-
K
-
E
----
V
I
K
A
M
A
S
V
S
R
--
Q
S
T
T
S
P
D
T
I
A
---
Q
W
A
T
L
E
A
L
T
--
N
Q
---
E
A
S
R
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
-
S
G
A
F
Y
V
L
--
M
D
T
S
P
I
A
-
P
D
E
V
R
A
A
E
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
G
--
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
--
32
PsiBlast_CBE
83.74
33%
-89
- C1 -
5BJ4
3
AAT_THET8
B:
[32-381]
-----------------------------------------------
D
L
V
A
L
T
A
G
E
P
---
D
---
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
--
P
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
--
H
F
S
P
G
R
V
---
A
--
P
---
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
--
C
G
P
-
K
-
E
----
V
I
K
A
M
A
S
V
S
R
--
Q
S
T
T
S
P
D
T
I
A
---
Q
W
A
T
L
E
A
L
T
--
N
Q
---
E
ASR
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
-
S
G
A
F
Y
V
L
--
M
D
T
S
P
I
A
-
P
D
E
V
R
A
A
E
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
G
--
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
--
43
PsiBlast_CBE
83.58
33%
-90
- C1 -
1B5O
3
AAT_THET8
B:
[32-381]
-----------------------------------------------
D
L
V
A
L
T
A
G
E
P
---
D
---
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
--
P
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
--
H
F
S
P
G
R
V
---
A
--
P
---
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
--
C
G
P
-
K
-
E
----
V
I
K
A
M
A
S
V
S
S
--
Q
S
T
T
S
P
D
T
I
A
---
Q
W
A
T
L
E
A
L
T
--
N
Q
---
E
ASR
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
-
S
G
A
F
Y
V
L
--
M
D
T
S
P
I
A
-
P
D
E
V
R
A
A
E
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
G
--
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
--
10
PsiBlast_PDB
83.52
33%
-89
- C1 -
5BJ4
3
AAT_THET8
A:
[32-381]
-----------------------------------------------
D
L
V
A
L
T
A
G
E
P
---
D
---
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
--
P
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
--
H
F
S
P
G
R
V
---
A
--
P
---
E
----
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
--
C
G
P
-
K
-
E
----
V
I
K
A
M
A
S
V
S
R
--
Q
S
T
T
S
P
D
T
I
A
---
Q
W
A
T
L
E
A
L
T
--
N
Q
---
E
A
S
R
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
G
L
K
A
V
R
P
-
S
G
A
F
Y
V
L
--
M
D
T
S
P
I
A
-
P
D
E
V
R
A
A
E
R
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
G
--
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
--