@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2419: (2016-04-03 )
MITLQNVVKEYTSRNNKVLAVDHVDLEIEQGEIFGVVGYSGAGKSTLIRMFNGLELPSAGTVEVDNLLISQIRGSKLRKARQQIGMIFQHFNLLWSRTVAENIAFPLEIAGVRGEKRRFRVNELIRLVGLEGKENAYPAELSGGQKQRVGIARALANNPKVLLCDEATSALDPQTTDEVLELLLDINKRLNLTIIVITHEMHVIRKICNRVAVMENGKVVELGDVLDVFRHPQEKVTQRFVRQVTDSDETEELIHLLLDNYAEGKIVKLLFMSENATQPVISQVAKENDVMLNVLHGNLTQTQNGAYGTLYVQVLGTEDAINASLTQLRQLKVETEVLER
Atome Classification :
(38 SA)
--.........10........20........30........40........50........60........70...----------.....80.-.......90........100..------------.-....---110-........120.......130..-.-.....140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240-----.......250.....-.--.260..--.....270.......280.......290.......300..-.....310.......320-.......330.......340-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MI
T
L
Q
N
V
V
K
E
Y
TSRN
N
K
V
L
A
V
D
H
V
D
L
E
I
EQ
G
E
I
F
G
V
VGYSGA
G
K
S
T
L
I
R
M
FNGLELPSAGT
V
E
V
D
N
L
L
I
S
Q
IR
G
----------
S
K
L
R
K
A
R
Q
-
Q
I
G
M
I
F
Q
H
F
N
L
L
W
S
R
T
V
A
E
NIA------------F-
P
L
E
I
---A-G-VRGE
K
R
R
F
R
V
N
E
L
I
R
L
VGL-EGK-E-NAYPAELSGGQ
K
Q
R
V
G
I
A
R
A
LANNP
K
V
L
L
CDEATSALDPQ
T
T
D
E
V
L
E
L
L
L
D
I
NKRL
N
L
T
I
I
V
I
TH
E
M
H
V
I
R
K
I
C
N
R
V
AVMENG
K
V
V
E
L
G
D
V
L
D
V
FRH
P
Q
E
K
V
T
Q
R
F
V
R
-----
Q
VTDS
D
E
T
E
E
L
I
H
L
L
-
L
--DNYAE
G
--
K
I
V
K
L
L
F
MSENAT
Q
P
V
I
S
Q
V
AKEN
D
V
M
L
N
V
LHGNLTQTQN-GA
Y
G
T
L
Y
V
Q
V
LGTEDA
I
N
-
A
S
L
T
Q
L
R
Q
L
K
V
E
T
E
V
LER---------
3
PsiBlast_PDB
93.80
44%
-116
- C1 -
3TUZ
3
METN_ECOLI
C:
[24-363]
--
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------------
L
-
P
L
E
L
---
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
-----
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
--
E
P
F
T
D
C
V-
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
-
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
-----------
124
Fugue
92.44
44%
-119
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
-H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------------
L
-
P
L
E
L
---
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
-----
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
-
Q
--
A
E
P
F
T
D
CV
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
-
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
------------
23
PsiBlast_CBE
92.36
44%
-118
- C1 -
3TUZ
3
METN_ECOLI
D:
[24-363]
--
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------------
L
-
P
L
E
L
---
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
-----
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
--
E
P
F
T
D
C
V-
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
-
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
-----------
2
PsiBlast_PDB
92.35
44%
-113
- C1 -
3TUI
1
METN_ECOLI
C:
[24-363]
--
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------------
L
-
P
L
E
L
---
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
-----
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
--
E
P
F
T
D
C
V-
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
-
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
-----------
25
PsiBlast_CBE
92.01
44%
-114
- C1 -
3TUI
1
METN_ECOLI
G:
[24-363]
--
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------------
L
-
P
L
E
L
---
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
-----
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
--
E
P
F
T
D
C
V-
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
-
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
-----------
21
PsiBlast_CBE
91.92
44%
-119
- C1 -
3TUZ
3
METN_ECOLI
H:
[24-362]
--
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------------
L
-
P
L
E
L
---
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
-----
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
--
E
P
F
T
D
C
V-
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
-
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
------------
24
PsiBlast_CBE
91.88
44%
-118
- C1 -
3TUI
1
METN_ECOLI
H:
[24-363]
--
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------------
L
-
P
L
E
L
---
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
-----
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
--
E
P
F
T
D
C
V-
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
-
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
-----------
26
PsiBlast_CBE
91.18
44%
-116
- C1 -
3TUI
1
METN_ECOLI
D:
[24-363]
--
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------------
L
-
P
L
E
L
---
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
-----
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
--
E
P
F
T
D
C
V-
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
-
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
-----------
103
HHSearch
91.17
45%
-107
- C1 -
3TUI
1
METN_ECOLI
C:
[24-365]
--
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------------
L
-
P
L
E
L
---
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
-----
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
-
Q
AE
P
F
T
D
C
V
--
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
-
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
G
Y
---------
22
PsiBlast_CBE
90.84
44%
-112
- C1 -
3TUZ
3
METN_ECOLI
G:
[24-363]
--
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------------
L
-
P
L
E
L
---
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
-----
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
--
E
P
F
T
D
C
V-
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
-
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
-----------
1
PsiBlast_PDB
87.87
45%
-106
- C1 -
3DHW
-
METN_ECOLI
C:
[1-340]
--
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
----------
S
E
L
T
K
A
R
R
-
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
------------
L
-
P
L
E
L
---
D
-
N
-
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
-
G
D
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
-----
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
--
E
P
F
T
D
C
V-
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
-
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
-----------
125
Fugue
69.87
31%
-97
- C1 -
1OXS
23
?
C:
[1-352]
MV
R
I
I
V
K
N
V
S
K
V
F
--
K
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
A
S
N
G
K
----------
L
I
V
P
P
E
D
R
-
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
------------
F
-
P
L
T
N
---
M
-
K
-
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
-
H
H
V
-
L
-
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
EINEL
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
-
F
--
P
V
S
V
S
S
--
D
R
A
I
I
G
I
R
P
E
D
---
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
I
F
-
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
KDKIKVFEK
17
PsiBlast_PDB
68.00
38%
-108
- C1 -
4YMS
-
?
J:
[1-239]
--
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-----------
V
N
I
N
K
V
R
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
------------
L
A
P
V
K
V
---
K
-
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
-
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
-----
K
I
----------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
67.56
38%
-104
- C1 -
4YMV
1
?
J:
[1-239]
--
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-----------
V
N
I
N
K
V
R
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
------------
L
A
P
V
K
V
---
K
-
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
-
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
-----
K
I
----------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
67.51
38%
-104
- C1 -
4YMV
1
?
A:
[1-239]
--
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-----------
V
N
I
N
K
V
R
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
------------
L
A
P
V
K
V
---
K
-
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
-
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
-----
K
I
----------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
67.12
38%
-108
- C1 -
4YMT
-
?
J:
[1-239]
--
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-----------
V
N
I
N
K
V
R
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
------------
L
A
P
V
K
V
---
K
-
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
-
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
-----
K
I
----------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
66.67
38%
-106
- C1 -
4YMU
2
?
J:
[1-239]
--
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-----------
V
N
I
N
K
V
R
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
------------
L
A
P
V
K
V
---
K
-
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
-
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
-----
K
I
----------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
66.39
38%
-107
- C1 -
4YMU
2
?
A:
[1-239]
--
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
G
K
-----------
V
N
I
N
K
V
R
Q
-
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
------------
L
A
P
V
K
V
---
K
-
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
-
L
D
K
-
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
-----
K
I
----------------------------------------------------------------------------------------------------------------
109
HHSearch
66.27
37%
-108
- C1 -
1OXX
22
?
K:
[3-242]
--
R
I
I
V
K
N
V
S
K
V
F
K
K
G
--
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
L
V
A
S
N
G
K
----------
L
I
V
P
P
E
D
R
-
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
------------
F
-
P
L
T
N
---
M
-
K
-
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
-
H
H
V
-
L
-
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
-----------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
65.62
40%
-115
- C1 -
2OUK
1
?
A:
[43-262]
-------------------------
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
----------
T
N
L
N
K
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
------------
L
A
P
M
K
V
---
R
-
K
-
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
-
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
-----
K
V
----------------------------------------------------------------------------------------------------------------
121
HHSearch
65.38
38%
-107
- C1 -
1B0U
4
HISP_SALTY
A:
[7-255]
---
L
H
V
I
D
L
H
K
R
Y
G
G
----
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KDGQLKVAD
K
N
Q
L
R
L
L
R
T
-
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
------------
E
-
A
P
I
Q
---
V
L
G
-
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
-
D
E
R
-
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
-----
G
-----------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
64.35
39%
-107
- C1 -
1B0U
4
HISP_SALTY
A:
[25-254]
-------------------------
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KDGQLKVAD
K
N
Q
L
R
L
L
R
T
-
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E-----------
A
-
P
I
Q
V
---
L
-
G
-
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
-
Q
-
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
-----------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
62.57
38%
-121
- C1 -
3TIF
7
Y796_METJA
B:
[1-223]
--
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
----------
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
------------
L
-
P
L
I
F
KYR
G
-
A
-
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
-
E
E
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
-
F
G
E
R
I
I
Y
L
K
D
G
E
V
----------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
62.29
40%
-107
* C1 *
2OLJ
4
?
A:
[24-259]
--
M
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
K
D
-----------
T
N
L
N
K
V
R
E
-
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
------------
L
-
A
P
M
K
---
V
-
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
-
K
D
K
-
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
59.73
33%
-103
- C1 -
1VCI
1
?
A:
[19-269]
-------------
T
K
R
F
G
N
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
T
Y
---------------
L
P
P
K
D
R
-
N
I
S
M
V
F
Q
------
H
M
T
V
Y
E
N
I
A
------------
F
-
P
L
-----
K
-
K
-
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
-
E
E
L
-
L
-
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
----
S
V
F
V
A
-----
T
F
I
G
A
P
E
M
N
I
L
E
V
S
V
-
G
--
D
G
Y
L
E
G
--
R
--------------------------------------------------------------------------------------
100
PsiBlast_CBE
53.90
33%
-97
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[8-235]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
----------
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
L
ANPGMS
V
E
K
V
I
Y
-
A
A
K
L
---
A
-
G
-
A
H
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
-
Q
G
--------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
--------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
52.94
33%
-95
- C1 -
1XEF
3
D:
[2-229]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
----------
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
LANPGMSVEKVI
Y
-
A
A
K
L
---
A
-
G
-
A
H
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
-
Q
G
--------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
--------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
52.79
33%
-99
- C1 -
2FGJ
2
D:
[8-235]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
----------
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
LANPGMSVEKVI
Y
-
A
A
K
L
---
A
-
G
-
A
H
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
-
Q
G
--------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
--------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
52.25
34%
-98
- C1 -
2PMK
1
A:
[4-231]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
----------
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
LANPGMS
V
E
K
V
I
Y
-
A
A
K
L
---
A
-
G
-
A
H
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
-
Q
G
--------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
--------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
52.15
33%
-98
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[8-235]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
----------
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
LANPGMSVEKVI
Y
-
A
A
K
L
---
A
-
G
-
A
H
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
-
Q
G
--------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
--------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
52.02
33%
-98
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[8-235]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
----------
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
LANPGMSVEKVI
Y
-
A
A
K
L
---
A
-
G
-
A
H
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
-
Q
G
--------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
--------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
51.87
33%
-96
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[8-236]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
----------
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
LANPGMSVEKVI
Y
-
A
A
K
L
---
A
-
G
-
A
H
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
-
Q
G
--------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
51.75
34%
-99
- C1 -
2FF7
1
A:
[8-235]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
----------
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
LANPGMS
V
E
K
V
I
Y
-
A
A
K
L
---
A
-
G
-
A
H
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
-
Q
G
--------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
--------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
51.66
33%
-95
- C1 -
2FGK
2
D:
[8-236]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
----------
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
LANPGMSVEKVI
Y
-
A
A
K
L
---
A
-
G
-
A
H
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
-
Q
G
--------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
51.40
33%
-96
- C1 -
2FFA
2
A:
[8-235]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
----------
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
LANPGMS
V
E
K
V
I
Y
-
A
A
K
L
---
A
-
G
-
A
H
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
-
Q
G
--------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
--------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
51.15
33%
-95
- C1 -
3B5J
1
A:
[4-231]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
----------
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
LANPGMS
V
E
K
V
I
Y
-
A
A
K
L
---
A
-
G
-
A
H
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
-
Q
G
--------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
--------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
51.11
33%
-96
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[8-236]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
----------
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
LANPGMS
V
E
K
V
I
Y
-
A
A
K
L
---
A
-
G
-
A
H
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
-
Q
G
--------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
51.02
33%
-97
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[8-236]
---
I
T
F
R
N
I
R
F
R
Y
K
P
D
S
P
V
I
L
--
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
----------
N
W
L
R
R
----
Q
V
G
V
V
L
Q
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
LANPGMSVEKVI
Y
-
A
A
K
L
---
A
-
G
-
A
H
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
-
Q
G
--------
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
-------------------------------------------------------------------------------------------------------------------------------