@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2641: (2016-04-05 )
MQLHAMWDEYPALSKDLQEVLQTIEKNIQIRDKHVEQNVKDLIHAGGKLLRPAFALLSAQAGPDYDKDRAVSIAAALEVLHMATLIHDDVVDDSPLRRGIPTIHSKYGRNYAVYTGDYLFCICFKILSAHASSVENIEFNSKNIEKILMGELDQMRTSYKMNVTVREYLTRISGKTAQLFALSCYSGATGSKATRMTVAKCYNIGHYLGMAFQIIDDVLDYTSTDEGLGKPVLNDMKQGIYSLPLIYAMKGHLAEFEPLLSQKLDMTDEASEQVLALISKYKGVEQAFKLAKKYTNKALREIKKLPAGAYREDMYRLTKNILDRDI
Atome Classification :
(25 SA)
--.........10........-20........30.........40..----......50...--.....60.---.-....---...70-.........80........90-.........100.......110.......120......-----.130----.....----...140-...--......150........160..--.....170.......180.......190.......200.-......210.......220.......230.......240.....----..250-...---..-----....260....----.-----..270-...---.....280.......290.......300.......310.......320....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--M
Q
L
H
A
M
W
DEYP
A
L
S
K
D
L
Q
E
-
V
L
Q
T
I
E
KN
I
Q
I
-
R
D
K
H
V
E
Q
N
V
K
D
L
I
----
H
AG
G
K
L
L
R
P
A
F
--
A
L
L
SAQ-A---G-PDYD---KD
R
A
--
V
S
I
A
A
A
L
E
V
L
H
M
A
T
L
I
HDDV--VDD
S
P
L
RRGI
P
T
I
H
S
KYGR
N
Y
A
V
YTG
D
Y
L
F
C
I
C
F
K
I
L
S
-----
A
H
A-----SSV
E
N
----
I
EFN---
S
K
N
--
I
E
K
I
L
M
G
E
-
L
D
Q
M
R
T
SY
K
M
N
V
T
--
V
R
E
Y
L
T
R
ISGK
T
A
Q
L
F
A
L
S
CYSGATGSK
A
T
R
M
T
V
A
K
C
YN-
I
G
H
Y
L
G
M
A
F
Q
I
I
D
D
V
LDYTSTDEGLG
K
P
V
L
N
D
M
K
Q
G
I
Y
S
L
P
L
I
Y
----
A
MK---G
H
L
---
A
E
-----
F
E
P
L
L
S
Q
KLDM----T-----
D
E
A
S
--
E
Q
V
---
L
A
L
I
S
KYK
G
V
E
Q
A
F
K
L
A
K
K
Y
T
N
K
A
L
R
E
I
K
KLPA
G
A
Y
R
E
D
M
Y
R
L
T
K
N
I
LDRDI
1
PsiBlast_PDB
96.89
37%
-99
- C1 -
3PKO
2
?
A:
[14-333]
-------
L
W
R
Q
F
P
Q
V
E
P
Q
L
T
A
-
L
Q
D
Y
L
L
R
T
V
Q
L
-
D
N
Q
P
I
H
H
K
I
L
A
L
L
----
K
S
G
G
K
L
L
R
P
G
Y
--
F
Y
L
F
S
T
-
F
---
G
-
N
A
A
T
---
P
A
Q
L
--
Q
A
G
A
A
A
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D
D
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D
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N
A
I
Y
A
G
D
F
M
F
T
V
Y
F
D
Q
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-----
K
S
T
-----
T
D
R
S
L
----
I
Q
N
H
---
I
D
A
--
M
H
R
I
L
Q
G
E
-
L
H
Q
M
D
L
N
Y
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E
D
I
T
--
L
D
A
Y
L
N
E
I
A
G
K
T
A
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L
F
A
L
S
C
Y
Q
G
A
Q
L
A
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A
P
Q
S
V
I
D
R
T
R
D
-
I
G
I
A
I
G
C
A
Y
Q
M
L
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D
I
L
D
Y
A
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D
P
K
R
T
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K
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P
L
L
L
----
S
L
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---
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A
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---
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-----
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L
L
K
K
K
Q
A
M
----
T
-----
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D
I
--
K
H
V
---
Q
A
L
V
A
Q
Y
D
G
V
G
A
A
K
Q
L
A
Q
D
Y
T
D
R
A
L
T
L
I
Q
Q
L
P
V
G
S
A
Q
Q
S
L
E
Q
L
T
R
L
L
L
R
R
D
-
2
PsiBlast_PDB
96.54
37%
-96
- C1 -
3N3D
4
?
A:
[7-325]
-------
L
W
R
Q
F
P
Q
V
E
P
Q
L
T
A
-
L
Q
D
Y
L
L
R
T
V
Q
L
-
D
N
Q
P
I
H
H
K
I
L
A
L
L
----
K
S
G
G
K
L
L
R
P
G
Y
--
F
Y
L
F
S
T
-
F
---
G
-
N
A
A
T
---
P
A
Q
L
--
Q
A
G
A
A
A
I
E
I
L
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V
G
T
L
I
H
D
D
V
--
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D
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S
P
T
R
R
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V
R
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I
Q
M
T
Y
G
Q
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N
A
I
Y
A
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D
F
M
F
T
V
Y
F
D
Q
V
L
-----
K
S
T
-----
T
D
R
S
L
----
I
Q
N
H
---
I
D
A
--
M
H
R
I
L
Q
G
E
-
L
H
Q
M
D
L
N
Y
R
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T
--
L
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A
Y
L
N
E
I
A
G
K
T
A
E
L
F
A
L
S
C
Y
Q
G
A
Q
L
A
G
A
P
Q
S
V
I
D
R
T
R
D
-
I
G
I
A
I
G
C
A
Y
Q
M
L
D
D
I
L
D
Y
A
G
D
P
K
R
T
Q
K
P
V
L
E
D
L
R
S
G
V
Y
S
L
P
L
L
L
----
S
L
S
---
H
A
P
---
R
D
-----
F
H
K
L
L
K
K
K
Q
A
M
----
T
-----
L
E
D
I
--
K
H
V
---
Q
A
L
V
A
Q
Y
D
G
V
G
A
A
K
Q
L
A
Q
D
Y
T
D
R
A
L
T
L
I
Q
Q
L
P
V
G
S
A
Q
Q
S
L
E
Q
L
T
R
L
L
L
R
R
--
60
HHSearch
95.53
37%
-101
- C1 -
3PKO
2
?
A:
[14-333]
-------
L
W
R
Q
F
P
Q
V
E
P
Q
L
T
A
-
L
Q
D
Y
L
L
R
T
V
Q
L
-
D
N
Q
P
I
H
H
K
I
L
A
L
L
----
K
S
G
G
K
L
L
R
P
G
Y
--
F
Y
L
F
S
T
-
F
---
G
-
N
A
A
T
---
P
A
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L
--
Q
A
G
A
A
A
I
E
I
L
H
V
G
T
L
I
H
D
D
V
--
I
D
D
S
P
T
R
R
G
V
R
T
I
Q
M
T
Y
G
Q
R
N
A
I
Y
A
G
D
F
M
F
T
V
Y
F
D
Q
V
L
-----
K
S
T
T----
D
R
S
-
L
----
I
Q
N
H
---
I
D
A
--
M
H
R
I
L
Q
G
E
-
L
H
Q
M
D
L
N
Y
R
E
D
I
T
--
L
D
A
Y
L
N
E
I
A
G
K
T
A
E
L
F
A
L
S
C
Y
Q
G
A
Q
L
A
G
A
P
Q
S
V
I
D
R
T
R
D
-
I
G
I
A
I
G
C
A
Y
Q
M
L
D
D
I
L
D
Y
A
G
D
P
K
R
T
Q
K
P
V
L
E
D
L
R
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G
V
Y
S
L
P
L
L
L
----
S
L
S
---
H
A
P
---
R
---------
D
F
H
K
L
L
K
K
----
K
QAMT-
L
E
D
I
--
K
H
V
---
Q
A
L
V
A
Q
Y
D
G
V
G
A
A
K
Q
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A
Q
D
Y
T
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A
L
T
L
I
Q
Q
L
P
V
G
S
A
Q
Q
S
L
E
Q
L
T
R
L
L
L
R
R
D
-
22
PsiBlast_CBE
95.45
37%
-97
- C1 -
3N3D
1
?
B:
[7-325]
-------
L
W
R
Q
F
P
Q
V
E
P
Q
L
T
A
-
L
Q
D
Y
L
L
R
T
V
Q
L
-
D
N
Q
P
I
H
H
K
I
L
A
L
L
----
K
S
G
G
K
L
L
R
P
G
Y
--
F
Y
L
F
S
T
-
F
---
G
-
N
A
A
T
---
P
A
Q
L
--
Q
A
G
A
A
A
I
E
I
L
H
V
G
T
L
I
H
D
D
V
--
I
D
D
----------
Q
M
T
Y
G
Q
R
N
A
I
Y
A
G
D
F
M
F
T
V
Y
F
D
Q
V
L
-----
K
S
T
-----
T
D
R
S
L
----
I
Q
N
H
---
I
D
A
--
M
H
R
I
L
Q
G
E
-
L
H
Q
M
D
L
N
Y
R
E
D
I
T
--
L
D
A
Y
L
N
E
I
A
G
K
T
A
E
L
F
A
L
S
C
Y
Q
G
A
Q
L
A
G
A
P
Q
S
V
I
D
R
T
R
D
-
I
G
I
A
I
G
C
A
Y
Q
M
L
D
D
I
L
D
Y
A
G
D
P
K
R
T
Q
K
P
V
L
E
D
L
R
S
G
V
Y
S
L
P
L
L
L
----
S
L
S
---
H
A
P
---
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D
-----
F
H
K
L
L
K
K
K
Q
A
M
----
T
-----
L
E
D
I
--
K
H
V
---
Q
A
L
V
A
Q
Y
D
G
V
G
A
A
K
Q
L
A
Q
D
Y
T
D
R
A
L
T
L
I
Q
Q
L
P
V
G
S
A
Q
Q
S
L
E
Q
L
T
R
L
L
L
R
R
--
21
PsiBlast_CBE
93.73
37%
-97
- C1 -
3PKO
1
?
B:
[14-333]
-------
L
W
R
Q
F
P
Q
V
E
P
Q
L
T
A
-
L
Q
D
Y
L
L
R
T
V
Q
L
-
D
N
Q
P
I
H
H
K
I
L
A
L
L
----
K
S
G
G
K
L
L
R
P
G
Y
--
F
Y
L
F
S
T
-
F
---
G
-
N
A
A
T
---
P
A
Q
L
--
Q
A
G
A
A
A
I
E
I
L
H
V
G
T
L
I
H
D
D
V
--
I
--------------
T
Y
G
Q
R
N
A
I
Y
A
G
D
F
M
F
T
V
Y
F
D
Q
V
L
-----
K
S
T
-----
T
D
R
S
L
----
I
Q
N
H
---
I
D
A
--
M
H
R
I
L
Q
G
E
-
L
H
Q
M
D
L
N
Y
R
E
D
I
T
--
L
D
A
Y
L
N
E
I
A
G
K
T
A
E
L
F
A
L
S
C
Y
Q
G
A
Q
L
A
G
A
P
Q
S
V
I
D
R
T
R
D
-
I
G
I
A
I
G
C
A
Y
Q
M
L
D
D
I
L
D
Y
A
G
D
P
K
R
T
Q
K
P
V
L
E
D
L
R
S
G
V
Y
S
L
P
L
L
L
----
S
L
S
---
H
A
P
---
R
D
-----
F
H
K
L
L
K
K
K
Q
A
M
----
T
-----
L
E
D
I
--
K
H
V
---
Q
A
L
V
A
Q
Y
D
G
V
G
A
A
K
Q
L
A
Q
D
Y
T
D
R
A
L
T
L
I
Q
Q
L
P
V
G
S
A
Q
Q
S
L
E
Q
L
T
R
L
L
L
R
R
D
-
3
PsiBlast_PDB
85.26
32%
-88
- C1 -
3AQB
3
HEXB_MICLU
B:
[16-323]
--------------------
E
-
V
E
K
R
L
Y
E
C
I
Q
S
-
D
S
E
T
I
N
K
A
A
H
H
I
L
----
S
S
G
G
K
R
V
R
P
M
F
--
V
L
L
S
G
F
-
L
---
N
--
D
T
Q
---
K
D
D
L
--
I
R
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
---------
N
I
-----
A
T
I
N
N
----
S
K
F
H
Q
I
F
S
K
T
--
I
L
E
V
C
F
G
E
-
F
D
Q
M
A
D
R
F
N
Y
P
V
S
--
F
T
A
Y
L
R
R
I
N
R
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
L
D
E
Q
S
T
Y
H
I
K
Q
-
F
G
H
C
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
A
----
A
I
----
A
N
L
---
K
E
Q
DDD
K
L
E
A
V
V
K
H
L
T
S
T
----
S
-----
D
D
E
V
--
Y
Q
Y
---
I
V
S
Q
V
K
Q
Y
G
I
E
P
A
E
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
N
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
--
57
HHSearch
84.37
31%
-85
* C1 *
3AQB
3
HEXB_MICLU
B:
[8-324]
------------
A
F
L
N
P
Y
I
I
E
-
V
E
K
R
L
Y
E
C
I
Q
S
-
D
S
E
T
I
N
K
A
A
H
H
I
L
----
S
S
G
G
K
R
V
R
P
M
F
--
V
L
L
S
G
F
-
L
---
N
-
D
T
-
Q
---
K
D
D
L
--
I
R
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
N
I
A
-----
T
I
N
-----
N
S
K
-
F
----
H
Q
I
F
---
S
K
T
--
I
L
E
V
C
F
G
E
-
F
D
Q
M
A
D
R
F
N
Y
P
V
S
--
F
T
A
Y
L
R
R
I
N
R
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
L
D
E
Q
S
T
Y
H
I
K
Q
-
F
G
H
C
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
A
----
A
I
A
---
N
L
K
---
E
Q
-----
D
D
D
K
L
E
A
V
V
K
H
----
L
TSTSD
D
E
V
Y
--
Q
Y
I
---
V
S
Q
V
K
Q
Y
G
-
I
E
P
A
E
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
N
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
V
-
23
PsiBlast_CBE
84.28
32%
-90
- C1 -
3AQC
5
HEXB_MICLU
D:
[16-323]
--------------------
E
-
V
E
K
R
L
Y
E
C
I
Q
S
-
D
S
E
T
I
N
K
A
A
H
H
I
L
----
S
S
G
G
K
R
V
R
P
M
F
--
V
L
L
S
G
F
-
L
---
N
--
D
T
Q
---
K
D
D
L
--
I
R
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
---------
N
I
-----
A
T
I
N
N
----
S
K
F
H
QIF
S
K
T
--
I
L
E
V
C
F
G
E
-
F
D
Q
M
A
D
R
F
N
Y
P
V
S
--
F
T
A
Y
L
R
R
I
N
R
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
L
D
E
Q
S
T
Y
H
I
K
Q
-
F
G
H
C
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
A
----
A
I
----
A
N
L
---
K
E
QDDDK
L
E
A
V
V
K
H
L
T
S
T
----
S
-----
D
D
E
V
--
Y
Q
Y
---
I
V
S
Q
V
K
Q
Y
G
I
E
P
A
E
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
N
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
--
24
PsiBlast_CBE
84.18
32%
-88
- C1 -
3AQB
3
HEXB_MICLU
D:
[16-323]
--------------------
E
-
V
E
K
R
L
Y
E
C
I
Q
S
-
D
S
E
T
I
N
K
A
A
H
H
I
L
----
S
S
G
G
K
R
V
R
P
M
F
--
V
L
L
S
G
F
-
L
---
N
--
D
T
Q
---
K
D
D
L
--
I
R
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
---------
N
I
-----
A
T
I
N
N
----
S
K
F
H
QIF
S
K
T
--
I
L
E
V
C
F
G
E
-
F
D
Q
M
A
D
R
F
N
Y
P
V
S
--
F
T
A
Y
L
R
R
I
N
R
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
L
D
E
Q
S
T
Y
H
I
K
Q
-
F
G
H
C
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
A
----
A
I
----
A
N
L
---
K
E
QDDDK
L
E
A
V
V
K
H
L
T
S
T
----
S
-----
D
D
E
V
--
Y
Q
Y
---
I
V
S
Q
V
K
Q
Y
G
I
E
P
A
E
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
N
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
--
4
PsiBlast_PDB
83.98
32%
-88
- C1 -
3AQC
5
HEXB_MICLU
B:
[16-323]
--------------------
E
-
V
E
K
R
L
Y
E
C
I
Q
S
-
D
S
E
T
I
N
K
A
A
H
H
I
L
----
S
S
G
G
K
R
V
R
P
M
F
--
V
L
L
S
G
F
-
L
---
N
--
D
T
Q
---
K
D
D
L
--
I
R
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
---------
N
I
-----
A
T
I
N
N
----
S
K
F
H
Q
I
F
S
K
T
--
I
L
E
V
C
F
G
E
-
F
D
Q
M
A
D
R
F
N
Y
P
V
S
--
F
T
A
Y
L
R
R
I
N
R
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
L
D
E
Q
S
T
Y
H
I
K
Q
-
F
G
H
C
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
A
----
A
I
----
A
N
L
---
K
E
Q
DDD
K
L
E
A
V
V
K
H
L
T
S
T
----
S
-----
D
D
E
V
--
Y
Q
Y
---
I
V
S
Q
V
K
Q
Y
G
I
E
P
A
E
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
N
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
--
82
Fugue
83.29
30%
-80
- C1 -
3AQB
3
HEXB_MICLU
B:
[5-325]
---------
S
Y
K
A
F
L
N
P
Y
I
I
E
-
V
E
K
R
L
Y
E
C
I
Q
S
-
D
S
E
T
I
N
K
A
A
H
H
I
L
----
S
S
G
G
K
R
V
R
P
M
F
--
V
L
L
S
G
F
-
L
-----
N
D
T
Q
---
K
D
D
L
--
I
R
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
N
I
A
-----
T
I
------
N
N
S
K
F
----
H
Q
I
F
---
S
K
T
--
I
L
E
V
C
F
G
E
-
F
D
Q
M
A
D
R
F
N
Y
P
V
S
--
F
T
A
Y
L
R
R
I
N
R
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
L
D
E
Q
S
T
Y
H
I
K
Q
-
F
G
H
C
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
A
----
A
I
A
---
N
L
K
---
E
Q
-----
D
D
D
K
L
E
A
V
V
K
H
LTST
S
-----
D
D
E
V
--
Y
Q
Y
---
I
V
S
Q
V
K
Q
Y
G
I
E
P
A
E
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
N
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
V
Y
59
HHSearch
82.55
28%
-81
- C1 -
1WY0
2
?
A:
[3-341]
------
K
Y
E
E
L
F
A
R
I
K
E
K
A
K
L
-
I
D
E
K
I
F
E
L
I
P
E
K
D
P
R
V
L
Y
E
A
A
R
H
Y
P
----
L
A
G
G
K
R
V
R
P
F
V
--
V
L
T
S
T
E
-
A
---
V
-
G
G
-
D
---
P
L
R
A
--
I
Y
P
A
V
A
I
E
L
I
H
N
Y
S
L
V
H
D
D
I
--
M
D
M
D
E
T
R
R
G
K
P
T
V
H
R
I
W
G
V
N
M
A
I
L
A
G
D
L
L
F
S
K
A
F
E
A
V
A
-----
R
A
E
IP
P
E
K
K
A
R
-
V
----
L
E
V
I
---
V
K
A
--
S
N
E
L
C
E
G
Q
-
A
R
D
L
E
F
E
K
K
S
T
V
T
--
I
E
E
Y
M
E
M
I
S
G
K
T
G
A
L
F
E
A
S
A
K
V
G
G
I
I
G
T
D
N
E
E
Y
I
K
A
L
S
S
-
W
G
R
N
V
G
I
A
F
Q
I
W
D
D
V
L
D
L
I
A
D
E
K
K
L
G
K
P
V
G
S
D
I
R
K
G
K
K
T
L
I
V
A
H
----
F
F
E
---
N
A
D
---
E
K
-----
D
K
Q
R
F
L
K
I
F
G
K
-----D
I
---
K
S
D
V
--
M
E
A
---
I
D
L
L
K
K
Y
G
S
I
D
Y
A
A
E
I
A
K
D
M
I
K
K
A
N
E
A
L
R
I
L
P
K
S
K
A
R
M
D
L
E
L
L
A
K
F
I
V
E
R
E
-
26
PsiBlast_CBE
80.91
34%
-79
- C1 -
3OYR
4
?
B:
[60-343]
---------------------------------------------
L
I
----
A
A
G
G
K
R
L
R
P
L
M
--
T
V
A
A
A
R
L
A
---
G
-
A
D
N
D
---
H
F
Q
----
K
L
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
G
S
Q
L
R
R
G
K
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
L
M
------
V
E
T
-----
N
S
M
K
A
----
L
E
I
L
---
A
R
A
--
S
R
V
I
A
E
G
E
-
V
L
Q
L
M
R
S
H
D
L
N
L
S
--
Q
A
V
Y
L
E
I
I
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
V
D
V
A
K
S
E
A
L
R
D
-
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
G
G
A
T
E
T
L
G
K
N
A
G
D
D
F
R
E
G
K
A
T
L
P
L
L
L
----
A
I
A
R
SG
P
R
E
---
A
E
-----
F
W
E
R
A
I
G
R
R
E
Q
----
T
-----
E
A
D
F
--
R
R
A
---
R
E
L
I
I
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
D
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
7
PsiBlast_PDB
79.97
27%
-93
- C1 -
3Q2Q
5
?
A:
[34-350]
------------
P
E
L
T
A
R
I
N
D
-
A
M
V
Q
V
E
E
L
L
H
T
-
E
L
S
S
G
E
D
F
L
V
D
I
V
M
H
L
T
R
A
G
G
K
R
F
R
P
M
F
--
A
L
L
A
S
E
-
F
---
G
-
E
K
P
L
---
S
E
N
V
--
I
K
A
A
V
V
V
E
I
T
H
L
A
T
L
Y
H
D
D
V
--
M
D
E
A
-------
S
A
N
A
R
W
D
N
S
V
A
I
L
A
G
D
I
L
L
A
H
A
S
G
L
M
S
-----
Q
L
G
-----
T
--
D
T
----
V
A
H
F
---
A
E
T
--
F
G
E
L
V
T
G
----
Q
M
R
E
T
V
G
P
R
D
T
D
P
I
E
H
Y
T
N
V
I
R
E
K
T
G
V
L
I
A
S
A
G
Y
L
G
A
M
H
A
G
A
A
P
E
H
I
D
A
L
K
N
-
F
G
A
A
V
G
M
I
F
Q
I
V
D
D
I
I
D
I
F
S
E
T
H
----
T
P
G
T
D
L
R
E
G
V
F
T
L
P
V
L
Y
----
A
L
R
---
E
D
T
P
V
G
A
E
-----
L
R
D
I
L
T
G
P
L
E
-----
D
-----
D
E
T
V
--
N
H
V
---
L
E
L
L
S
Q
S
G
G
R
Q
A
A
L
D
E
V
Y
R
Y
M
D
I
A
N
A
E
L
D
R
L
P
D
S
T
V
K
E
A
L
R
N
L
A
T
F
T
V
K
R
--
85
Fugue
79.45
29%
-91
- C1 -
3OYR
1
?
A:
[20-343]
KS
G
S
V
D
R
L
V
R
L
---
A
E
A
D
M
A
G
-
V
N
R
L
I
T
D
R
M
Q
S
-
D
V
A
I
I
P
A
L
A
E
H
L
I
----
A
A
G
G
K
R
L
R
P
L
M
--
T
V
A
A
A
R
-
L
-----
A
G
A
D
---
N
D
H
F
--
Q
K
L
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
V
A
A
---------
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
L
M
V
------
E
T
-----
N
S
M
K
A
----
L
E
I
L
---
A
R
A
--
S
R
V
I
A
E
G
E
-
V
L
Q
L
M
R
S
H
D
L
N
L
S
--
Q
A
V
Y
L
E
I
I
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
V
D
V
A
K
S
E
A
L
R
D
-
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
A
T
-------------------
L
P
L
L
L
----
A
I
A
---
R
S
G
---
P
R
-----
E
A
E
F
W
E
R
A
I
G
-----
T
-----
E
A
D
F
--
R
R
A
---
R
E
L
I
I
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
D
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
54
HHSearch
77.57
30%
-89
- C1 -
3OYR
1
?
A:
[23-343]
------
S
V
D
R
L
V
R
L
A
E
A
D
M
A
G
-
V
N
R
L
I
T
D
R
M
Q
S
-
D
V
A
I
I
P
A
L
A
E
H
L
I
----
A
A
G
G
K
R
L
R
P
L
M
--
T
V
A
A
A
R
-
L
---
A
-
G
A
-
D
---
N
D
H
F
--
Q
K
L
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
---------
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
L
M
V
-----
E
T
N
-----
S
M
K
-
A
----
L
E
I
L
---
A
R
A
--
S
R
V
I
A
E
G
E
-
V
L
Q
L
M
R
S
H
D
L
N
L
S
--
Q
A
V
Y
L
E
I
I
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
V
D
V
A
K
S
E
A
L
R
D
-
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
-------------------
A
T
L
P
L
L
L
----
A
I
A
---
R
S
G
---
P
R
-----
E
A
E
F
W
E
R
A
I
G
------T----
E
A
D
F
--
R
R
A
---
R
E
L
I
I
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
D
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
6
PsiBlast_PDB
76.37
31%
-94
- C1 -
3WJO
2
?
A:
[53-333]
---------------------------------------------
I
V
----
S
G
G
G
K
R
I
R
P
M
I
--
A
V
L
A
A
R
-
A
-----
V
G
Y
E
---
G
N
A
H
--
V
T
I
A
A
L
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
D
M
R
R
G
K
A
T
A
N
A
A
F
G
N
A
A
S
V
L
V
G
D
F
I
Y
T
R
A
F
Q
M
M
T
-----
S
-
L
-----
G
S
L
K
V
----
L
E
V
M
---
S
E
A
--
V
N
V
I
A
E
G
E
-
V
L
Q
L
M
N
-----------
N
Y
M
R
V
I
Y
S
K
T
A
R
L
F
E
A
A
A
Q
C
S
G
I
L
A
G
C
T
P
E
E
E
K
G
L
Q
D
-
Y
G
R
Y
L
G
T
A
F
Q
L
I
D
D
L
L
D
Y
N
A
--------
V
G
D
D
L
N
E
G
K
P
T
L
P
L
L
H
----
A
M
H
---
H
G
T
---
P
E
-----
Q
A
Q
M
I
R
T
A
I
E
Q
----
G
-----
N
G
R
H
L
L
E
P
V
---
L
E
A
M
N
A
C
G
S
L
E
W
T
R
Q
R
A
E
E
E
A
D
K
A
I
A
A
L
Q
V
L
P
D
T
P
W
R
E
A
L
I
G
L
A
H
I
A
V
----
12
PsiBlast_PDB
76.25
30%
-79
- C1 -
1WY0
2
?
A:
[44-341]
----------------------------------------------------
A
G
G
K
R
V
R
P
-
F
--
V
V
L
T
S
T
-
E
---
A
-
V
G
G
D
---
P
L
R
A
--
I
Y
P
A
V
A
I
E
L
I
H
N
Y
S
L
V
H
D
D
I
--
M
D
M
D
E
T
R
R
G
K
P
T
V
H
R
I
W
G
V
N
M
A
I
L
A
G
D
L
L
F
S
K
A
F
E
A
V
A
-----
R
A
E
-----
I
P
P
E
K
K
A
R
V
L
E
V
I
---
V
K
A
--
S
N
E
L
C
E
G
Q
-
A
R
D
L
E
F
E
K
K
S
T
V
T
--
I
E
E
Y
M
E
M
I
S
G
K
T
G
A
L
F
E
A
S
A
K
V
G
G
I
I
G
T
D
N
E
E
Y
I
K
A
L
S
S
-
W
G
R
N
V
G
I
A
F
Q
I
W
D
D
V
L
D
L
I
A
D
E
K
K
L
G
K
P
V
G
S
D
I
R
K
G
K
K
T
L
I
V
A
H
F
F
E
N
A
D
E
---
K
D
K
---
Q
R
-----
F
L
K
I
F
G
K
--
D
I
----
K
-----
S
D
V
M
--
E
A
I
----
D
L
L
K
K
Y
G
S
I
D
Y
A
A
E
I
A
K
D
M
I
K
K
A
N
E
A
L
R
I
L
P
K
S
K
A
R
M
D
L
E
L
L
A
K
F
I
V
E
R
E
-
13
PsiBlast_PDB
76.22
29%
-78
- C1 -
3AQ0
4
SPS3_ARATH
A:
[14-338]
-------
V
A
D
E
L
S
L
L
S
N
K
L
R
E
M
V
L
A
E
V
P
K
L
A
S
A
-
A
E
Y
F
F
K
R
G
V
Q
----------
G
K
Q
F
R
S
T
I
--
L
L
L
M
A
T
-
A
L
DV------SEL
R
V
R
Q
--
R
G
I
A
E
I
T
E
M
I
H
V
A
S
L
L
H
D
D
V
--
L
D
D
A
D
T
R
R
G
V
G
S
L
N
V
V
M
G
N
K
M
S
V
L
A
G
D
F
L
L
S
R
A
C
G
A
L
A
-----
A
L
K
-----
N
T
-
E
V
----
V
A
L
L
---
A
T
A
--
V
E
H
L
V
T
G
E
-
T
M
E
I
T
S
S
T
A
A
R
Y
S
--
M
D
Y
Y
M
Q
K
T
Y
Y
K
T
A
S
L
I
S
N
S
C
K
A
V
A
V
L
T
G
Q
T
A
E
V
A
V
L
A
F
E
-
Y
G
R
N
L
G
L
A
F
Q
L
I
D
D
I
L
D
F
T
G
T
S
A
S
L
G
K
G
S
L
S
D
I
R
H
G
V
I
T
A
P
I
L
F
----
A
M
E
----------
E
-----
F
-
P
Q
L
R
E
V
V
D
Q
----
V
-----
A
A
D
P
--
R
N
V
D
I
A
L
E
Y
L
G
K
S
K
G
I
Q
R
A
R
E
L
A
M
E
H
A
N
L
A
A
A
A
I
G
S
L
P
E
-
T
D
N
E
D
V
K
R
S
R
R
A
L
I
D
---
25
PsiBlast_CBE
74.75
31%
-98
- C1 -
3WJN
1
?
B:
[53-335]
---------------------------------------------
I
V
----
S
G
G
G
K
R
I
R
P
M
I
--
A
V
L
A
A
R
-
A
-----
V
G
Y
E
---
G
N
A
H
--
V
T
I
A
A
L
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
------------
F
G
N
A
A
S
V
L
V
G
D
F
I
Y
T
R
A
F
Q
M
M
T
-----
S
-
L
-----
G
S
L
K
V
----
L
E
V
M
---
S
E
A
--
V
N
V
I
A
E
G
E
-
V
L
Q
L
M
N
V
N
D
P
D
I
T
--
E
E
N
Y
M
R
V
I
Y
S
K
T
A
R
L
F
E
A
A
A
Q
C
S
G
I
L
A
G
C
T
P
E
E
E
K
G
L
Q
D
-
Y
G
R
Y
L
G
T
A
F
Q
L
I
D
D
L
L
D
Y
N
-------
K
N
V
G
D
D
L
N
E
G
K
P
T
L
P
L
L
H
----
A
M
H
---
H
G
T
---
P
E
-----
Q
A
Q
M
I
R
T
A
I
E
Q
----
G
-----
N
G
R
H
L
L
E
P
V
---
L
E
A
M
N
A
C
G
S
L
E
W
T
R
Q
R
A
E
E
E
A
D
K
A
I
A
A
L
Q
V
L
P
D
T
P
W
R
E
A
L
I
G
L
A
H
I
A
V
Q
R
--
8
PsiBlast_PDB
74.14
34%
-89
- C1 -
3OYR
1
?
A:
[60-343]
---------------------------------------------
L
I
----
A
A
G
G
K
R
L
R
P
L
M
--
T
V
A
A
A
R
L
A
---
G
-
A
D
N
D
---
H
F
Q
----
K
L
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
---------
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
L
M
------
V
E
T
-----
N
S
M
K
A
----
L
E
I
L
---
A
R
A
--
S
R
V
I
A
E
G
E
-
V
L
Q
L
M
R
S
H
D
L
N
L
S
--
Q
A
V
Y
L
E
I
I
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
V
D
V
A
K
S
E
A
L
R
D
-
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
-------------------
A
T
L
P
L
L
L
----
A
I
A
R
S
G
P
R
E
---
A
E
-----
F
W
E
R
A
I
G
--------
T
-----
E
A
D
F
--
R
R
A
---
R
E
L
I
I
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
D
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
45
PsiBlast_CBE
51.94
32%
-61
- C1 -
3Q1O
5
?
C:
[42-251]
-------------------------------------
Y
L
E
K
A
F
F
E
M
V
----
L
N
G
G
K
R
F
R
P
K
L
FL
A
V
L
C
A
L
-
V
---
G
Q
K
D
Y
S
---
N
Q
Q
T
EY
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
PC
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
NALLE
S
H
I
------
I
V
E
L
----
I
K
I
L
---
S
A
N
GG
I
K
G
M
I
L
G
Q
A
L
D
C
Y
F
E
N
T
P
L
N
L
E
--
Q
L
T
F
L
H
E
--
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
I
K
D
E
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
-----------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
51.88
32%
-57
- C1 -
3Q1O
3
?
D:
[42-251]
-------------------------------------
Y
L
E
K
A
F
F
E
M
V
----
L
N
G
G
K
R
F
R
P
K
L
FL
A
V
L
C
A
L
-
V
---
G
Q
K
D
Y
S
---
N
Q
Q
T
EY
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
PC
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
NALLE
S
H
I
------
I
V
E
L
----
I
K
I
L
---
S
A
N
GG
I
K
G
M
I
L
G
Q
A
L
D
C
Y
F
E
N
T
P
L
N
L
E
--
Q
L
T
F
L
H
E
--
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
I
K
D
E
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
-----------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
51.74
32%
-62
- C1 -
3Q1O
4
?
A:
[42-251]
-------------------------------------
Y
L
E
K
A
F
F
E
M
V
----
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
-
V
---
G
Q
K
D
Y
S
---
N
Q
Q
T
E
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
PC
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
N
ALLE
S
H
I
------
I
V
E
L
----
I
K
I
L
---
S
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
C
Y
F
E
N
T
P
L
N
L
E
--
Q
L
T
F
L
H
E
--
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
I
K
D
E
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
-----------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
51.10
32%
-59
- C1 -
3Q1O
3
?
B:
[42-251]
-------------------------------------
Y
L
E
K
A
F
F
E
M
V
----
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
-
V
---
G
Q
K
D
Y
S
---
N
Q
Q
T
E
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
PC
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
N
ALLE
S
H
I
------
I
V
E
L
----
I
K
I
L
---
S
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
C
Y
F
E
N
T
P
L
N
L
E
--
Q
L
T
F
L
H
E
--
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
I
K
D
E
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
-----------------------------------------------------------------------------------------------------------------------------