@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2760: (2016-04-07 )
MTIVAMNEVVKSFTGDIILEKVSLQLEEGERVGLIGRNGEGKSTILKILKGTEGVDSGIVTSKKGARIGLLEQLSSVDPNIIVEHYLRTSFGELEDMEKELRSLEAEMATNASEKLMNRYGDKMALFGELGGYEMDANLNKVVNGLGIGKLLSQSWGDLSGGEKTKTALAHLLLQKTDLLLLDEPTNHLDLMAVEWLTAFLQHYSGTVLVVSHDRYFLDEVVEKMVELENRELIVYHTNFSGYLKEREERLLREFQDYKDQQKKIKKMQQAIKRLRQWAMQANPPNDAMFRRAKNMERALERMEKVKRPVLTQKQMQLQFDEAGRSGQEVVVMENLSKSFSEKTIVQEVSLQIRQGERVAIIGENGAGKSTLLKIMEGKVVPDDGVIKVGASVKIASLSQQMEELNEEMTVLDAFRDKVAVTEGEARQMLAGFMFYGEMVFRKVRNISGGERMRLRLAQFINMPVNTLILDEPTNHLDIASREVLEEAIRAFSGTIITVSHDRYFIDQLCSKVIWLENKQLTVYEGNYSYATSKRR
Atome Classification :
(20 SA)
---------------------------------------------------------------------........------.10....-------....20.....-...30.........40........50......--..60...--------------.--..--..70.....-.-..--80....--....90........100.......110..--.....120.......130.......140.......150-........160.......170....--.--.--.180.......190.......200..----..---...210.......220......------.230.......240.......250.......260.......270.......280.......290.......300.......310...--....320.......330.......340.--.......350.......360.......370..---------..-.------..380---------------------.......390----.------------.------------.----------..----------------------...400------------------------------.-..-------------------------------.------------------------------------------------------------------------.---------------.----------------------------------------------------------------..410---------------------------------------------------......-----.-----.------------------------------------------.---------420-----.---........430.....--..-440.......450.......460...---....470.......480.......490----..---.----....500...-....510.-.-..------.------..--520..-------...-..-530....---------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------
M
T
I
V
A
M
N
E
------
V
V
K
S
FT
G
-------
D
I
I
L
E
K
V
S
L
Q
L-EEG
E
-
R
V
G
L
IGRNGE
G
K
S
T
I
L
K
I
L
KGTEGVDS--GIVTSKK--------------G--AR--
I
G
L
L
E
Q
L
S
S-V-D
P
--
N
I
I
V
E
H
--
Y
L
R
T
SFG
E
L
E
D
M
E
K
E
L
R
S
L
E
A
E
MAT
N
A
S
E
--
K
L
M
N
RYGD
K
M
A
L
F
GELGGYEMDA
N
L
N
K
V
V
N
GL
G
I
G
K
-
L
-
L
S
Q
SWGDLSGG
E
K
T
K
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A
L
A
H
L
L
LQK--T--
D
--
L
L
L
LDEPTN
H
L
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L
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HY----S
G
---
T
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V
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R
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F
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L
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L
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K
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A
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MQANPP
N
D
A
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F
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A
K
N
M
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A
L
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M
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VKRPV
L
T
Q
K
Q
--
M
Q
L
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EAGRSG
Q
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L
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S
F
S
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RQG
E
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V
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I
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GENGA
G
K
S
T
L
L
K
---------
I
M-E------GKVVP---------------------DD
G
V
I
K
VGA-----
S
------------
V
------------
K
----------
I
A
----------------------
S
L
S
Q
Q
-------------------------------
M
-
E
E
-------------------------------
L
------------------------------------------------------------------------
N
---------------
E
----------------------------------------------------------------
E
M
T
-----------------------------------------------------
V
L
D
A
F
R
-----
D
-----
K
------------------------------------------V---------A-------V---TE
G
E
A
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Q
M
L
A
G
F
M
F
Y
G
--
E
M
-
V
F
R
K
V
RNISG
G
E
R
M
R
L
R
L
A
Q
F
INMPV---
N
T
L
I
LDEPTNHLD
I
A
S
R
E
V
L
E
E
A
I
R
AF----S
G
---
T
----
I
I
T
VSH
D
R
Y
F
-
I
D
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L
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K
V
-
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-
W
L------E------N
K
--
Q
L
T
V
Y
-------EG
N
-
Y
S-YATSKRR---------------------------------------------
21
HHSearch
90.15
28%
-94
- C- -
2IW3
7
EF3A_YEAST
A:
[439-979]
---------------------------------------------------------------------------
C
E
------
F
S
L
A
Y
G
A
-------
K
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N
K
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--------------
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--
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-------------------------------------------
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-------------------------
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L
P
---------------------
T
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-----
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------------
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------------
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----------
I
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----------------------
Y
I
K
Q
H
-------------------------------
A
-
F
A
H
------------------------------
I
------------------------------------------------------------------------
E
SHLDKT
P
S
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Y
I
Q
W
R
F
Q
----------------------------------------------------------------
T
G
E
DRETMDRANRQINEND
A
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A
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S
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L
L
G
E
N
I
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-----
M
-----
K
S
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R
W
V
P
M
M
SVD
N
A
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
GQF
R
---------
P
-------
L
---
T
R
K
E
I
E
E
H
C
S
M
L
G
L
D
P
--
E
I
V
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S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
---
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
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A
L
S
K
A
L
K
E
F
----
E
G
---
G
----
V
I
I
I
T
H
S
A
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F
-
T
K
N
L
T
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E
V
-
W
-
A
V
------
K
------
D
G
--
R
M
T
P
S
------------------------------------------------------------------
1
PsiBlast_PDB
83.13
33%
-70
- C1 -
3J5S
-
ETTA_ECOLI
D:
[27-542]
---------------------------------------------------------------------------------------------------
I
L
K
N
I
S
L
S
F
-
F
P
G
A
-
K
I
G
V
L
G
L
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G
A
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T
L
L
R
I
M
A
G
I
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K
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--
G
E
A
R
P
Q
P
--------------
D
--
I
K
--
I
G
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P
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L
-
N
P
--
E
H
T
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--
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A
V
S
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V
V
N
A
L
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D
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Y
A
L
Y
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P
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FD
K
L
A
A
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Q
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H
N
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A
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C
R
L
L
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L
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----
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G
---
T
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V
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A
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W
I
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L
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G
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P
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N
Y
S
S
W
L
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Q
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D
Q
R
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A
Q
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A
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A
A
R
R
K
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I
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K
E
L
-------
E
W
V
R
Q
G
-----
T
K
G
R
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S
K
G
K
A
R
-
L
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N
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S
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L
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G
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L
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L
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F
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A
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G
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G
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G
K
S
T
L
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---------
M
I
-
S
------
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Q
E
Q
P
---------------------
D
S
G
T
I
T
L
G
E
-----
T
------------
V
------------
K
----------
L
A
----------------------
S
V
D
Q
F
-------------------------------
R
-
D
S
-------------------------------
M
------------------------------------------------------------------------
D
---------------
N
----------------------------------------------------------------
S
K
T
-----------------------------------------------------
V
W
E
E
V
S
-----
G
GLDIM
K
------------------------------------------
I
---------
G
-------
N
---
T
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
--
V
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
---
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
G
---
C
----
A
M
V
I
S
H
D
R
W
F
-
L
D
R
I
A
T
H
I
-
L
D
Y
Q
------
D
------
E
G
--
K
V
E
F
F
-------
E
G
N
-
F
T
E
Y
E
E
Y
K
K
R
---------------------------------------------
2
PsiBlast_PDB
82.38
33%
-79
- C1 -
4FIN
12
ETTA_ECOLI
A:
[21-536]
---------------------------------------------------------------------------------------------------
I
L
K
N
I
S
L
S
F
-
F
P
G
A
-
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
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I
M
A
G
I
D
K
D
I
E
--
G
E
A
R
P
Q
P
--------------
D
--
I
K
--
I
G
Y
L
P
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P
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-
L
-
N
P
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H
T
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--
S
I
E
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A
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S
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V
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N
A
L
K
R
L
D
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Y
A
L
Y
A
D
P
D
A
D
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
I
Q
------
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
D
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W
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D
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L
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L
L
L
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A
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L
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F
L
H
D
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----
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G
---
T
V
V
A
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T
H
D
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Y
F
L
D
N
V
A
G
W
I
L
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I
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W
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N
Y
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W
L
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A
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A
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R
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-------
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V
R
Q
G
-----
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K
----
K
G
K
A
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-
L
A
R
F
E
E
L
N
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G
A
G
K
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T
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F
R
---------
M
I
-
S
------
G
Q
E
Q
P
---------------------
D
S
G
T
I
T
L
G
E
-----
T
------------
V
------------
K
----------
L
A
----------------------
S
V
D
Q
F
-------------------------------
R
-
D
S
-------------------------------
M
------------------------------------------------------------------------
D
---------------
N
----------------------------------------------------------------
S
K
T
-----------------------------------------------------
V
W
E
E
V
S
GGLDI
M
-----
K
------------------------------------------
I
---------
G
-------
N
---
T
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
--
V
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
---
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
L
R
A
L
E
N
A
L
L
E
F
----
P
G
---
C
----
A
M
V
I
S
H
D
R
W
F
-
L
D
R
I
A
T
H
I
-
L
D
Y
Q
------
D
------
E
G
--
K
V
E
F
F
-------
E
G
N
-
F
T
E
Y
E
E
Y
K
K
R
---------------------------------------------
25
HHSearch
65.99
21%
-70
* C1 *
3OZX
5
?
A:
[4-463]
----------------------------------------------------------------------------
E
------
V
I
H
R
Y
K
V
N------
G
F
K
L
F
G
L
P
T
-
P
-
K
N
N
T
-
I
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
L
A
G
E
I
I
P
N
F
--
G
D
P
N
S
K
V
G
K
D
E
V
L
K
R
F
R----
G
--
K
E
--
I
Y
N
Y
F
K
E
L
Y
---
S
N
--
E
L
K
I
V
H
--
K
I
Q
Y
V
E
Y
-
A
------
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K
F
L
K
G
T
-----------------
V
N
---
E
I
L
T
K
I
D
E
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G
K
K
D
E
V
K
E
L
L
N
M
T
N
-
L
-
W
N
K
D
A
N
I
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
--
A
--
D
--
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
R
E
R
M
N
M
A
K
A
I
R
E
L
L
K--
N
K
---
Y
V
I
V
V
D
H
D
L
I
V
L
D
Y
L
T
D
L
I
H
I
I
------
Y
-
G
E
S
S
V
Y
-
G
R
V
S
K
S
Y
A
A
R
V
G
I
N
-----
N
F
---------
L
K
G
Y
L
P
A
--
E
---------
N
M
K
I
R
P
-
D
E
I
K
F
M
L
K
---------------------------
L
K
T
K
M
K
W
T
K
I
I
K
K
L
G
----
D
F
Q
L
V
V
D
N
G
E
A
K
E
G
E
I
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
---------
I
L
-
V
------
G
E
I
T
A
---------------------
D
E
G
S
V
T
P
E
K
------------------
Q
------------
I
----------
L
S
----------------------
Y
K
P
Q
R
-------------------------------
I
-
F
--------------------------------
P
------------------------------------------------------------------------
N
---------------
Y
----------------------------------------------------------------
D
G
T
-----------------------------------------------------
V
Q
Q
Y
L
E
-----
N
-----
A
------------------------------------------
S
---------
K
DALS---
T
---
S
S
W
F
F
E
E
V
T
K
R
L
N
L
H
R
---
L
-
L
E
S
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
---
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
I
V
A
K
A
I
K
R
V
T
R
E
R
K
A
---
V
----
T
F
I
I
D
H
D
L
S
I
-
H
D
Y
I
A
D
R
I
-
I
-
V
F
------
K
------
G
E
--
P
----------------------------------------------------------------------
24
HHSearch
65.33
24%
-61
- C1 -
1YQT
4
?
A:
[25-480]
---------------------------------------------------------------------------
E
D
------
C
V
H
R
Y
G
V
N------
A
F
V
L
Y
R
L
P
-
V
V
-
K
E
G
M
-
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
CG
D
N
D
S
W
D
G
--------------
V
--
I
R
A
F
R
G
N
E
L
Q
N
Y
F
E
K
-
L
K
--
N
G
E
I
R
P
--
V
V
K
P
Q
Y
V
D
L
---------
I
P
K
A
V
K
----------
G
K
V
------
I
E
L
L
K
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
E
L
E
N
-
V
-
L
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R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
--
A
--
T
--
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
-
G
K
---
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
------
Y
G
E
P
-----
G
V
Y
G
I
F
S
Q
P
K
G
T
R
N
---------------
G
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N
E
F
L
R
---
G
Y
L
K
------
D
--------
E
N
V
R
F
R
P
Y
E
-
I
K
F
T
K
T
-
G
E
----
R
V
-----
E
I
E
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
G
-
S
---
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
---------
M
L
-
A
------
G
V
E
E
P
---------------------
T
E
G
K
I
E
W
D
L
-------------------------------
T
----------
V
A
----------------------
Y
K
P
Q
Y
-------------------------------
I
-
K
A
--------------------------------------------------------------------------------------------------------
D
---------------
Y
----------------------------------------------------------------
E
G
T
-----------------------------------------------------
V
Y
E
L
L
S
-----
K
-----
I
------------------------------------------
D
---------
A
S
K
L
----
N
---
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
---
D
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
---
T
----
A
L
V
V
E
H
D
V
L
M
-
I
D
Y
V
S
D
R
L
-
M
-
V
F
------
E
------
G
E
--
P
G
---------------------------------------------------------------------
22
HHSearch
64.17
22%
-58
- C1 -
3BK7
4
?
A:
[83-547]
-----------------------------------------------------------------------
A
I
S
I
V
N
------
L
P
E
Q
L
D
E
D
CVHRYG
V
N
A
F
V
L
Y
R
L
P
I
V
K
D
G
M
-
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
--
C
E
D
N
D
S
W
--------------
D
---
N
--
V
I
R
A
F
R
G
N
E
-
L
-
Q
N
--
Y
F
E
R
L
K
N
G
E
I
R
P
V
V
K
P
-----
Q
Y
V
D
L
L
P
K
A
V
K
----------
G
K
V
R
------
E
L
L
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
-
V
-
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
--
A
--
H
--
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
-
G
K
---
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
------
Y
G
E
P
-----
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
---------------
G
I
N
E
F
L
Q
G
Y
L
K
-------
D
E
N
V
R
F
---
R
P
Y
E
I
R
F
T
K
L
-----
S
E
-------------
R
V
D
V
E
R
E
T
L
V
E
Y
P
R
L
V
K
D
Y
G
-
S
---
F
K
L
E
V
E
P
G
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R
K
G
E
V
I
G
I
V
G
P
N
G
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G
K
T
T
F
V
K
---------
M
L
-
A
------
G
V
E
E
P
---------------------
T
E
G
K
V
E
W
D
L
-------------------------------
T
----------
V
A
----------------------
Y
K
P
Q
Y
-------------------------------
I
-
K
A
--------------------------------------------------------------------------------------------------------
E
---------------
Y
----------------------------------------------------------------
E
G
T
-----------------------------------------------------
V
Y
E
L
L
S
-----
K
-----
I
------------------------------------------
D
---------
S
-------
S
K
L
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
---
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
---
T
----
A
L
V
V
E
H
D
V
L
M
-
I
D
Y
V
S
D
R
L
-
I
-
V
F
------
E
------
G
--------------------------------------------------------------------------
47
Fugue
63.64
20%
-56
- C1 -
3J16
4
RLI1_YEAST
B:
[1-608]
MS
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCRQ
E
C
K
R
S
C
P
V
V
K
T
GKLC
I
E
V
T
PTSK
I
A
F
I
S
EILCIGCG
I
C
V
K
K
CPFDA
I
Q
I
I
N
L
P
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N
L
E
A
H
V
T
H
R
Y
S
A
N
-------
S
F
K
L
H
R
L
P
-
T
P
-
R
P
G
Q
-
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
L
--
G
R
F
D
D
P
P
--------------
E
--------
W
Q
E
I
I
K
Y
-
F
-
R
G
--
S
E
L
Q
N
Y
--
F
T
K
M
L
E
D
D
I
K
A
I
I
K
P
Q
Y
V
D
N
I
P
R
A
I
K
G
P
V
--
Q
K
V
G
E
L
L
K
L
R
-------
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
N
-
V
-
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
--
A
--
D
--
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
----
L
A
P
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
------
Y
G
V
P
------
S
V
Y
G
V
V
T
L
P
------------------
A
S
V
R
E
G
I
N
I
F
L
D
G
H
I
---
P
A
E
N
L
R
F
R
T
E
A
L
Q
F
R
I
A
D
A
T
E
D
L
Q
N
D
------------------
S
A
S
R
A
F
S
Y
P
S
L
K
K
T
Q
G
-
D
--
F
V
L
N
V
E
E
G
E
-
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
---------
L
L
-
A
------
G
A
L
K
P
---------------------
D
E
G
--
Q
D
I
P
-----
K
------------
L
------------
N
----------
V
S
----------------------
M
K
P
Q
K
-------------------------------
I
-
A
P
-------------------------------
K
------------------------------------------------------------------------
F
---------------
P
----------------------------------------------------------------
G
-
T
-----------------------------------------------------
V
R
Q
L
F
F
-----
K
-----
K
------------------------------------------
I
RG-------
Q
-------
F
---
L
N
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
--
D
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
----
I
L
---
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
-
A
T
Y
L
A
D
K
V
-
I
-
V
F
------
E
------
G
I
PS
K
N
A
H
A
-------
R
A
P
-
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S
-
L
L
T
G
C
N
R
F
L
K
N
L
NVTFRRDPNSF
R
P
R
I
N
K
L
DS
Q
M
D
K
E
Q
K
S
S
GNYFFLDNTGI
45
Fugue
61.72
22%
-44
- C1 -
1YQT
4
?
A:
[24-538]
--------------------------------------------------------------------------
E
E
D
------
C
V
H
R
Y
-
G
-------
V
N
A
F
V
L
Y
R
L
P
V
-
V
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
--
C
G
D
N
D
S
W
--------------
D
--
G
V
--
I
R
A
F
R
G
------------------------
N
E
L
Q
N
Y
F
E
K
L
K
N
G
E
I
R
P
V
V
K
P
Q
Y
--
V
D
L
I
P
K
A
V
K
G
K
V
I
E
L
L
K
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
E
L
E
N
-
V
-
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
--
A
--
T
--
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
----
S
E
E
G
K
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
------
Y
G
E
P
G
V
Y
G
I
F
S
Q
P
K
G
T
R
N
G
I
N
E
F
L
R
G
Y
L
K
D
E
N
V
R
F
R
P
Y
E
I
K
------------------------------------------------
F
T
K
T
G
E
R
V
E
I
E
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
G
----
S
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
--------
L
A
--------
G
V
E
E
P
---------------------
T
E
G
K
I
E
W
D
L
-----
T
------------
V
------------
A
----------
Y
K
----------------------
P
---
Q
-------------------------------
Y
-
I
K
-------------------------------
A
------------------------------------------------------------------------
D
---------------
Y
----------------------------------------------------------------
E
G
T
-----------------------------------------------------
V
Y
E
L
L
S
-----
K
-----
I
------------------------------------------
D
---------
A
-------
S
---
K
L
N
S
N
F
Y
K
T
E
L
L
K
P
L
G
II
D
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
---
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
---
E
K
N
E
K
T
----
A
L
V
V
E
H
D
-
V
L
M
I
D
Y
V
S
D
R
L
M
V
-
F
E
------
G
------
E
P
--
G
K
Y
G
R
A
L
P
PMG
M
R
E
G
M
N
R
-
F
L
A
S
I
G
I
T
F
R
R
D
PDTG
R
P
R
A
N
K
EGS
V
K
D
R
E
Q
K
E
K
GEYYYIA-----------
23
HHSearch
61.59
22%
-62
- C1 -
3J16
2
RLI1_YEAST
B:
[81-543]
---------------------------------------------------------------------------
A
H
------
V
T
H
R
Y
S
A
N------
S
F
K
L
H
R
L
P
-
T
P
-
R
P
G
Q
-
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
L
--
G
R
F
D
D
P
P
--------------
E
W
Q
E
I
--
I
K
Y
F
-
R
G
S
E
-
L
-
Q
N
Y
F
T
K
M
L
E
D
--
D
I
K
A
I
I
K
P
Q
-----
Y
V
D
N
I
P
R
A
I
K
G
P
----------
V
Q
K
V
G
E
L
L
K
-
L
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
N
-
V
-
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
--
A
--
D
--
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
-
T
K
---
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
------
Y
G
V
P
S
V
-
Y
-
G
V
V
T
L
P
A
S
V
R
E
G
I
-----
N
I
F
---------
L
D
G
H
I
P
A
E
--
N
L
R
--------------
F
R
T
E
A
L
Q
-
F
R
-
I
A
D
A
T
E
-
D
L
----------
Q
N
D
S
A
S
R
A
F
S
Y
P
S
L
K
K
T
Q
--
G
--
D
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
---------
L
L
-
A
------
G
A
L
K
P
---------------------
D
E
G
Q
D
I
P
-------
K
------------
L
------------
N
----------
V
S
----------------------
M
K
P
Q
K
-------------------------------
I
-
A
P
-------------------------------
K
----------------------------------------------------------------------------------------
F
----------------------------------------------------------------
P
G
T
-----------------------------------------------------
V
R
Q
L
F
F
-----
K
-----
K
------------------------------------------
I
---------
R
GQF----
L
---
N
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
---
D
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
---
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
L
H
N
K
K
---
T
----
A
F
I
V
E
H
D
F
I
M
-
A
T
Y
L
A
D
K
V
-
I
-
V
F
------
E
------
G
--------------------------------------------------------------------------
29
HHSearch
60.80
21%
-60
- C1 -
3PIH
4
UVRA_THEMA
A:
[355-901]
-------------------------------------------------------------------------------------------------
V
P
K
V
Q
R
W
H
R
E
T
----
E
-
M
K
E
W
L
E
K
N
F
I
V
Q
R
T
C
S
V
C
G
G
R
R
L
N
R
E
A
--
L
S
V
K
I
N
G
-----------------
L
N
--
I
H
E
---------
F
T
--
E
L
S
I
S
E
--
E
L
E
F
L
K
N
-
L
N
L
-
T
E
R
E
R
E
I
-----------------
V
-------
G
E
L
-
L
K
E
I
-
E
K
R
L
E
F
L
V
D
V
G
L
E
Y
L
T
-
L
S
R
S
A
T
T
L
S
G
G
E
S
Q
R
I
R
L
A
T
Q
I
G
S
G
--
L
--
T
G
V
I
Y
V
L
D
E
P
T
I
G
L
H
P
R
D
T
E
R
L
I
K
T
L
K
K
L
R
D
L
-
G
N
---
T
V
I
V
V
E
H
D
E
E
V
I
R
-
N
A
D
H
I
I
D
I
G
PGGGT
N
G
G
R
V
V
F
Q
-
G
T
V
D
E
L
L
K
N
P
D
S
S
L
T
----------------
G
E
Y
L
S
----------------------
G
K
R
K
------
I
T
V
N
--------------
K
T
R
R
L
P
Y
A
S
L
K
I
K
G
V
R
--------
H
N
N
L
K
N
I
D
V
E
I
P
L
G
V
F
V
C
V
T
G
V
S
G
S
G
K
S
S
L
V
M
ET
L
Y
P
A
L
M
N
L
L
-
H
K
T
K
L
P
A
G
E
F
D
S
---------------------
I
E
G
H
E
N
I
D
K
M
I
A
I
D
Q
------------
S
------------
P
----------
I
G
RTPRSN
P
A
T
Y
T
K
V
F
D
E
I
R
S
L
F
A
M
T
P
A
A
K
A
R
GYNKSRFSFNLKGGRCEACQGQG
Y
V
K
I
E
M
-
L
F
L
P
D
V
Y
V
E
CDVCKGKRYN
R
E
T
L
E
ITYKGKN
I
S
D
------------------------------------------------------------------------
I
---------------
L
----------------------------------------------------------------
D
M
T
-----------------------------------------------------
V
D
E
A
L
E
-----
F
-----
F
------------------------------------------
K
---------
N
I------
P
---
S
I
K
R
T
L
Q
V
L
H
D
V
G
L
G
Y
--
V
K
-
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
I
K
L
A
S
E
L
R
K
R
D
TG
R
T
L
Y
I
L
D
E
P
T
V
G
L
H
F
E
D
V
R
K
L
V
E
V
L
H
R
L
V
D
R
-
G
N
---
T
----
V
I
V
I
E
H
N
L
D
V
-
I
K
-
N
A
D
H
I
-
I
-
D
L
G
PEGGK
E
------
G
G
--
Y
I
V
A
--------
T
G
T
-
P
E
-
E
I
A
-------------------------------------------------
28
HHSearch
56.02
22%
-64
- C1 -
2VF7
3
?
A:
[361-825]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
L
H
L
G
L
G
Y
-
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
LF
G
--
V
--
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
-
G
N
---
S
L
F
V
V
E
H
D
L
D
V
I
R
R
-
A
D
W
L
V
D
V
G
PEAGE
K
G
G
E
I
L
Y
-
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
-----------------
Q
Y
L
F
----------------------------
A
D
--
R
H
T
E
P
-------------
H
T
P
R
E
P
A
G
W
L
E
L
N
G
V
T
R
--------
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
---------
Q
A
L
V
------
D
A
L
A
A
H
F
GQ-------------------
G
S
A
R
L
G
G
-----
D
LAQIT
R
L
V
R
V
D
Q
K
PIGRTPRSN
M
A
T
Y
----------
T
G
----------------------
L
F
D
Q
V
-------------------------------
R
-
K
L
-------------------------------
F
------------------------------------------------------------------------
A
---------------
A
T
P
L
A
K
K
R
GYNAGRFSFNVKGGRCEHCQGEGWVMVELLFL
P
S
V
Y
A
P
CPVCHGTRYN
A
E
T
L
E
VEYR
G
K
N
-----------------------------------------------------
I
A
D
V
L
A
-----
L
-----
T
------------------------------------------
V
D
E
A
H
D
F
F
A
D
E
-------
S
---
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
--
L
R
-
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
RGG
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
A
-
G
N
---
T
----
V
I
A
V
E
H
K
M
Q
V
-
V
A
-
A
S
D
W
V
-
L
-
D
I
G
PGAGE
D
------
G
G
--
R
L
V
A
--------
Q
G
T
-
P
A
-
E
V
--------------------------------------------------
41
HHSearch
55.86
25%
-90
- C1 -
1Z47
1
?
A:
[11-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
--
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
---------
L
I
-
A
------
G
L
E
R
P
---------------------
T
K
G
D
V
W
I
G
G
-----
K
RVTDLPPQK---
R
------------
N
----------
V
G
----------------------
L
V
F
Q
N
-------------------------------
Y
-
A
--------------------------------
L
------------------------------------------------------------------------
F
---------------
Q
----------------------------------------------------------------
H
M
T
-----------------------------------------------------
V
Y
D
N
V
S
-----
F
-----
G
------------------------------------------
L
---------
R
E
K
RVP
K
D
E
---
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
---
Y
-
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
---
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
---
T
----
S
V
F
V
T
H
D
Q
E
E
-
A
L
E
V
A
D
R
V
-
L
-
V
L
------
H
------
E
G
--
N
V
E
Q
--------
F
G
T
-
P
E
-
E
V
--------------------------------------------------
30
HHSearch
55.82
26%
-84
- C1 -
1OXX
21
?
K:
[1-230]
---------------------------------------------------------------------
M
V
R
I
I
V
K
N
------
V
S
K
V
F
K
K
GK-----
V
V
A
L
D
N
V
N
I
N
I
-
E
N
G
E
-
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
--
G
E
L
Y
F
D
D
RLVASNGKLIVPPE
D
--
R
K
--
I
G
M
V
F
Q
T
W
A
-
L
-
Y
P
--
N
L
T
A
F
E
--
N
I
A
F
P
L
T
N
M
K
------------------------------------
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
-
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
--
P
--
S
--
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
QSRL
G
V
---
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
------
V
K
G
K
L
V
Q
V
-
G
K
P
E
D
L
Y
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
55.05
23%
-64
- C1 -
2R6F
3
?
A:
[487-940]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
Q
N
V
G
L
D
Y
L
T
-
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
--
L
TG
V
--
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L-
G
N
---
T
L
I
V
V
E
H
D
E
D
T
M
L
-
A
A
D
Y
L
I
D
I
G
PGAGI
H
G
G
E
V
V
A
A
-
G
T
P
E
E
V
M
N
D
P
N
S
L
T
-----------------
G
Q
Y
L
S
---
G
------------------
K
--
K
---
F
--
I
P
I
P
A
E
-------------
R
R
R
P
D
G
R
W
L
E
V
V
G
A
R
--------
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
---------
E
V
-
L
------
Y
K
A
L
A
Q
K
LHRAK
A
K
P
G
EHRDIRGLEH
L
D
K
V
I
D
I
D
Q
-----
S
------------
P
------------
I
GRTPRSN
P
A
T
Y
T
----------------------
G
V
F
D
D
-------------------------------
I
R
D
V
-------------------------------
F
A
S
T
N
E
A
K
V
R
GYKKGRFSFNVKGGRCEACHGDG
I
I
K
I
E
M
H
FL
P
D
V
Y
V
P
CEVCHGKRYNRETLEVTYKGKN
I
A
E
V
---------------
L
----------------------------------------------------------------
D
M
T
-----------------------------------------------------
V
E
D
A
L
D
-----
F
-----
F
------------------------------------------
A
---------
S
-------
I
P
--
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
--
M
K
-
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
NGR
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
N
-
G
D
---
T
----
V
L
V
I
E
H
N
L
D
V
-
I
-
K
T
A
D
Y
I
-
I
-
D
L
------
G
PEGGDR
G
G
--
Q
I
V
A
--------
V
G
T
-
P
E
-
E
V
--------------------------------------------------
33
HHSearch
54.96
26%
-82
- C1 -
2IT1
-
?
A:
[1-223]
---------------------------------------------------------------------
M
V
E
I
K
L
E
N
------
I
V
K
K
F
G
N
-------
F
T
A
L
N
N
I
N
L
K
I
-
K
D
G
E
-
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
--
G
K
I
Y
F
D
E
KDVTELPPK-----
D
--
R
N
--
V
G
L
V
F
Q
N
W
A
-
L
-
Y
P
--
H
M
T
V
Y
K
--
N
I
A
F
P
L
E
L
R
K
------------------------------------
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
-
L
-
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
--
P
--
E
--
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
---
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
------
R
E
G
E
I
L
Q
V
-
G
T
P
D
E
V
Y
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
53.78
25%
-86
- C1 -
3D31
-
?
A:
[1-217]
-----------------------------------------------------------------------
M
I
E
I
E
S
------
L
S
R
K
W
K
--------
N
F
S
L
D
N
L
S
L
K
V
-
E
S
G
E
-
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
P
D
S
--
G
R
I
L
L
D
G
KDVTDLSPE-----
K
--
H
D
--
I
A
F
V
Y
Q
N
Y
S
-
L
-
F
P
--
H
M
N
V
K
K
--
N
L
E
F
G
M
R
M
K
---------------------------------------
K
I
K
D
P
K
R
V
L
D
T
A
R
D
L
K
I
E
H
-
L
-
L
D
R
N
P
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
--
P
--
K
--
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
KN
K
L
---
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
------
M
D
G
K
L
I
Q
V
-
G
K
P
E
E
I
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
53.60
23%
-80
- C1 -
3TUI
1
METN_ECOLI
C:
[23-253]
----------------------------------------------------------------------
H
M
I
K
L
S
N
------
I
T
K
V
F
H
Q
GTRT---
I
Q
A
L
N
N
V
S
L
H
V
-
P
A
G
Q
-
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
--
G
S
V
L
V
D
G
QELTTLSESELTKA
R
--
R
Q
--
I
G
M
I
F
Q
H
F
N
-
L
-
L
S
--
S
R
T
V
F
G
--
N
V
A
L
P
L
E
L
D
N
------------------------------------
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
--
P
--
K
--
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
NRRL
G
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
------
S
N
G
E
L
I
E
Q
-
D
T
V
S
E
V
F
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
52.91
24%
-85
- C1 -
2YYZ
3
?
A:
[2-222]
----------------------------------------------------------------------
P
S
I
R
V
V
N
------
L
K
K
Y
F
G
K
-------
V
K
A
V
D
G
V
S
F
E
V
-
K
D
G
E
-
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
--
G
E
I
Y
F
D
D
VLVNDIPPK-----
Y
--
R
E
--
V
G
M
V
F
Q
N
Y
A
-
L
-
Y
P
--
H
M
T
V
F
E
--
N
I
A
F
P
L
R
A
R
R
------------------------------------
I
S
K
D
E
V
E
K
R
V
V
E
I
A
R
K
L
L
I
D
N
-
L
-
L
D
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
--
P
--
K
--
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
G
I
---
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
------
N
Q
G
K
L
V
Q
Y
-
G
T
P
D
E
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
52.75
23%
-87
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-223]
----------------------------------------------------------------------
A
S
V
Q
L
Q
N
------
V
T
K
A
W
G
E
-------
V
V
V
S
K
D
I
N
L
D
I
-
H
E
G
E
-
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
--
G
D
L
F
I
G
E
KRMNDTPPA-----
E
--
R
G
--
V
G
M
V
F
Q
S
Y
A
-
L
-
Y
P
--
H
L
S
V
A
E
--
N
M
S
F
G
L
K
L
A
G
------------------------------------
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
-
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
--
P
--
S
--
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
------
D
A
G
R
V
A
Q
V
-
G
K
P
L
E
L
Y
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
52.61
23%
-88
- C1 -
1V43
-
?
A:
[10-238]
---------------------------------------------------------------------
M
V
E
V
K
L
E
N
------
L
T
K
R
F
G
N
-------
F
T
A
V
N
K
L
N
L
T
I
-
K
D
G
E
-
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
--
G
R
I
Y
F
G
D
RDVTYLPPK-----
D
--
R
N
--
I
S
M
V
F
Q
----------
H
M
T
V
Y
E
--
N
I
A
F
P
L
--
K
K
------------------------------------
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
-
L
-
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
--
P
--
D
--
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
---
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
------
N
R
G
Q
L
L
Q
I
-
G
S
P
T
E
V
Y
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------