@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu12210: (2016-06-19 )
MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEENQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTPRVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKAWSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAEETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAVEEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRRHPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSFRVKM
Atome Classification :
(56 SA)
.........10........20.-.......30.......---.40----....------.-....50------------........60.----..-----------------------.---...----.-----------70--.--.-----.--------.-.--------...80-----.........90........100.......110.......120.----..---...-.130.......140.......150.......160.-...-.-----..170.......--180.......--190.......200-----......-...210.....-...-220.......230.......240.......250....-...260.....-.-.270.......280-----...---.-.-.---.290---.........-300.......310.......320.......330..-...--..340..-.....350.......360.......370..-.-.-.---..380--.-----.......390....--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MN
V
L
N
R
R
Q
A
L
Q
R
A
L
LNGKNKQD-AYHPF
P
W
Y
E
S
MRKDAP---VS-----FDEE------N-
Q
V
W
S
V
F
------------
L
Y
D
D
V
K
K
VVG
D
----
K
E
-----------------------
L
---
F
S
S
----C-----------MP--
Q
--
Q
-----
T
--------
S
-
S
--------IGNS------IINMDPPK
H
T
K
I
R
S
V
V
N
KAF
T
P
R
V
M
K
QW
E
P
R
I
Q
E
I
T
D
E
L
I
Q
K
F----QG---RSE-F
D
L
V
HDFSYP
L
P
V
I
V
I
S
E
L
LGV
P
S
A
H
M
E
Q
F
K
A
W
S
D
-
L
L
V-S-----TPKD
K
S
E
E
A
E
K
A
--
F
L
E
E
R
D
K
C
E
E
--
E
L
A
A
F
F
A
G
I
I
E
-------
E
KRNK
P
-
E
Q
D
I
I
-
S
I
L
V
E
-
A
E
E-TGEKLSG
E
E
L
I
P
F
C
T
L
L
LVAGN
E
T
T
T
N
L
I
S
N
A
M
Y
S
I
L-ETP
G
V
Y
E
E
L
R
S-
H
-
P
E
L
M
P
Q
A
V
E
E
A
L
RF-----RA
P
---
A
-
P
-
V
---
L
R
-----
R
I
A
K
RDTEI-G
G
H
L
IKEG
D
M
V
L
A
F
VASANRDEAKFDRP
H
M
F
DIRR-HPN--P
H
I
A
FGH-G
I
H
F
C
LGA
P
L
A
R
L
E
A
N
I
A
L
T
S
L
I
S
AFPH
M
E
-
C
-
V
-
S
---ITPI---E-----
N
S
V
I
Y
G
L
K
S
F
R
VKM--
119
HHSearch
92.14
100%
-135
- C6 -
4RM4
1
YJIB_BACSU
A:
[22-396]
---------------------
D
-
A
Y
H
P
F
P
W
Y
E
S
M
R
K
D
A
P
---
V
S
-----
F
D
E
E
------
N
-
Q
V
W
S
V
F
------------
L
Y
D
D
V
K
K
V
V
G
D
----
K
E
-----------------------
L
---
F
S
S
----
C
-----------
M
---------------------------------
G
N
S
------
I
I
N
M
D
P
P
K
H
T
K
I
R
S
V
V
N
K
A
F
T
P
R
V
M
K
Q
W
E
P
R
I
Q
E
I
T
D
E
L
I
Q
K
F
----
Q
G
---
R
S
E
-
F
D
L
V
H
D
F
S
Y
P
L
P
V
I
V
I
S
E
L
L
G
V
P
S
A
H
M
E
Q
F
K
A
W
S
D
-
L
L
V
-
S
-----
T
P
K
D
K
S
E
E
A
E
K
A
--
F
L
E
E
R
D
K
C
E
E
--
E
L
A
A
F
F
A
G
I
I
E
-------
E
K
R
N
K
P
-
E
Q
D
I
I
-
S
I
L
V
E
------
G
E
K
L
S
G
E
E
L
I
P
F
C
T
L
L
L
V
A
G
N
E
T
T
T
N
L
I
S
N
A
M
Y
S
I
L
-
E
T
P
G
V
Y
E
E
L
R
S
-
H
-
P
E
L
M
P
Q
A
V
E
E
A
L
R
F
-----
R
A
P
---
A
-
P
-
V
---
L
R
-----
R
I
A
K
R
D
T
E
I
-
G
G
H
L
I
K
E
G
D
M
V
L
A
F
V
A
S
A
N
R
D
E
A
K
F
D
R
P
H
M
F
D
I
R
R
-
H
P
N
--
P
H
I
A
F
G
H
-
G
I
H
F
C
L
G
A
P
L
A
R
L
E
A
N
I
A
L
T
S
L
I
S
A
F
P
H
M
E
-
C
-
V
-
S
---
I
T
P
I
---
E
-----
N
S
V
I
Y
G
L
K
S
F
R
V
K
M
--
1
PsiBlast_PDB
92.14
100%
-135
- C6 -
4RM4
1
YJIB_BACSU
A:
[22-396]
---------------------
D
-
A
Y
H
P
F
P
W
Y
E
S
M
R
K
D
A
P
---
V
S
-----
F
D
E
E
------
N
-
Q
V
W
S
V
F
------------
L
Y
D
D
V
K
K
V
V
G
D
----
K
E
-----------------------
L
---
F
S
S
----
C
-----------
M
---------------------------------
G
N
S
------
I
I
N
M
D
P
P
K
H
T
K
I
R
S
V
V
N
K
A
F
T
P
R
V
M
K
Q
W
E
P
R
I
Q
E
I
T
D
E
L
I
Q
K
F
----
Q
G
---
R
S
E
-
F
D
L
V
H
D
F
S
Y
P
L
P
V
I
V
I
S
E
L
L
G
V
P
S
A
H
M
E
Q
F
K
A
W
S
D
-
L
L
V
-
S
-----
T
P
K
D
K
S
E
E
A
E
K
A
--
F
L
E
E
R
D
K
C
E
E
--
E
L
A
A
F
F
A
G
I
I
E
-------
E
K
R
N
K
P
-
E
Q
D
I
I
-
S
I
L
V
E
------
G
E
K
L
S
G
E
E
L
I
P
F
C
T
L
L
L
V
A
G
N
E
T
T
T
N
L
I
S
N
A
M
Y
S
I
L
-
E
T
P
G
V
Y
E
E
L
R
S
-
H
-
P
E
L
M
P
Q
A
V
E
E
A
L
R
F
-----
R
A
P
---
A
-
P
-
V
---
L
R
-----
R
I
A
K
R
D
T
E
I
-
G
G
H
L
I
K
E
G
D
M
V
L
A
F
V
A
S
A
N
R
D
E
A
K
F
D
R
P
H
M
F
D
I
R
R
-
H
P
N
--
P
H
I
A
F
G
H
-
G
I
H
F
C
L
G
A
P
L
A
R
L
E
A
N
I
A
L
T
S
L
I
S
A
F
P
H
M
E
-
C
-
V
-
S
---
I
T
P
I
---
E
-----
N
S
V
I
Y
G
L
K
S
F
R
V
K
M
--
91
PsiBlast_CBE
75.27
35%
-130
- C6 -
3A4H
2
CPVDH_PSEAH
A:
[10-398]
----------
Q
H
D
L
F
S
G
T
F
W
Q
----
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
K
L
---
A
L
P
D
------
G
-
P
V
W
L
L
T
------------
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-----------------------
L
SKD
W
R
H
----
T
-----------
L
P
--
E
D-
Q
-----
R
--------
A
-
D
--------
M
P
A
T
PTPM--
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
----
P
T
---
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
-
V
L
V
D
D
-----
S
P
A
D
-------------
D
K
N
A
A
M
G
--
K
L
H
G
Y
L
S
D
L
L
E
-------
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
-
S
D
E
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
-
T
H
P
D
Q
R
K
L
L
A
E
-
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
-----
D
S
P
VSQ
A
-
P
-
I
----------
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
--
G
G
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
-
V
-
G
---
L
D
E
L
V
Y
R
E
-----
S
T
L
V
R
G
L
S
R
M
P
V
T
M
--
105
PsiBlast_CBE
74.88
34%
-129
- C6 -
3A50
8
CPVDH_PSEAH
A:
[10-398]
----------
Q
H
D
L
F
S
G
T
F
W
Q
----
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
KL---
A
L
P
D
------
G
-
P
V
W
L
L
T
------------
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-----------------------
L
---
S
K
D
----
W
RHRLPEDQRAD
M
P
--
A
--
T
-----
P
--------
T
-
P
--------
M
---------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
----
P
T
---
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
-
V
L
V
D
D
-----
S
P
A
D
-------------
D
K
N
A
A
M
G
--
K
L
H
G
Y
L
S
D
L
L
E
-------
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
-
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
-
T
H
P
D
Q
R
K
L
L
A
E
-
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
-----
D
S
P
VSQ
A
-
P
-
I
----------
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
--
G
G
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
-
V
-
G
---
L
D
E
L
V
Y
R
R
-----
S
T
L
V
R
G
L
S
R
M
P
V
T
M
--
100
PsiBlast_CBE
74.81
34%
-132
- C6 -
3A51
8
CPVDH_PSEAH
A:
[10-398]
----------
Q
H
D
L
F
S
G
T
F
W
Q
----
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
KL---
A
L
P
D
------
G
-
P
V
W
L
L
T
------------
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-----------------------
L
---
S
K
D
----
W
RHRLPEDQRAD
M
P
--
A
--
T
-----
P
--------
T
-
P
--------
M
---------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
----
P
T
---
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
-
V
L
V
D
D
-----
S
P
A
D
-------------
D
K
N
A
A
M
G
--
K
L
H
G
Y
L
S
D
L
L
E
-------
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
-
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
-
T
H
P
D
Q
R
K
L
L
A
E
-
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
-----
D
S
P
VSQ
A
-
P
-
I
----------
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
--
G
G
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
-
V
-
G
---
L
D
E
L
V
Y
R
R
-----
S
T
L
V
R
G
L
S
R
M
P
V
T
M
--
93
PsiBlast_CBE
74.80
34%
-134
- C6 -
3VRM
2
CPVDH_PSEAH
A:
[10-398]
----------
Q
H
D
L
F
S
G
T
F
W
Q
----
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
K
L
---
A
L
P
D
------
G
-
P
V
W
L
L
T
------------
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-----------------------
L
SKD
W
R
H
----
T
-----------
L
P
--
E
D-
Q
-----
R
--------
A
-
D
--------
M
P
A
T
PTPM--
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
A
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
----
P
T
---
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
-
V
L
V
D
D
-----
S
P
A
D
-------------
D
K
N
A
A
M
G
--
K
L
H
G
Y
L
S
D
L
L
E
-------
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
-
S
D
E
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
-
T
H
P
D
Q
R
K
L
L
A
E
-
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
-----
D
S
P
VSQ
A
-
P
-
I
----------
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
--
G
G
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
-
V
-
G
---
L
D
E
L
V
Y
R
E
-----
S
T
L
V
R
G
L
S
R
M
P
V
T
M
--
101
PsiBlast_CBE
74.67
34%
-128
- C6 -
3A50
4
CPVDH_PSEAH
E:
[10-398]
----------
Q
H
D
L
F
S
G
T
F
W
Q
----
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
KL---
A
L
P
D
------
G
-
P
V
W
L
L
T
------------
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-----------------------
L
---
S
K
D
----
W
RHRLPEDQRAD
M
P
--
A
--
T
-----
P
--------
T
-
P
--------
M
---------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
----
P
T
---
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
-
V
L
V
D
D
-----
S
P
A
D
-------------
D
K
N
A
A
M
G
--
K
L
H
G
Y
L
S
D
L
L
E
-------
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
-
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
-
T
H
P
D
Q
R
K
L
L
A
E
-
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
-----
D
S
P
VSQ
A
-
P
-
I
----------
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
--
G
G
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
-
V
-
G
---
L
D
E
L
VYR
R
-----
S
T
L
V
R
G
L
S
R
M
P
V
T
M
--
96
PsiBlast_CBE
74.65
34%
-128
- C6 -
3A51
4
CPVDH_PSEAH
E:
[10-398]
----------
Q
H
D
L
F
S
G
T
F
W
Q
----
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
KL---
A
L
P
D
------
G
-
P
V
W
L
L
T
------------
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-----------------------
L
---
S
K
D
----
W
RHRLPEDQRAD
M
P
--
A
--
T
-----
P
--------
T
-
P
--------
M
---------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
----
P
T
---
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
-
V
L
V
D
D
-----
S
P
A
D
-------------
D
K
N
A
A
M
G
--
K
L
H
G
Y
L
S
D
L
L
E
-------
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
-
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
-
T
H
P
D
Q
R
K
L
L
A
E
-
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
-----
D
S
P
VSQ
A
-
P
-
I
----------
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
--
G
G
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
-
V
-
G
---
L
D
E
L
VYR
R
-----
S
T
L
V
R
G
L
S
R
M
P
V
T
M
--
108
PsiBlast_CBE
74.58
34%
-129
- C6 -
3A4Z
4
CPVDH_PSEAH
C:
[10-398]
----------
Q
H
D
L
F
S
G
T
F
W
Q
----
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
KL---
A
L
P
D
------
G
-
P
V
W
L
L
T
------------
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-----------------------
L
---
S
K
D
----
W
RHRLPEDQRAD
M
P
--
A
--
T
-----
P
--------
T
-
P
--------
M
---------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
----
P
T
---
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
-
V
L
V
D
D
-----
S
P
A
D
-------------
D
K
N
A
A
M
G
--
K
L
H
G
Y
L
S
D
L
L
E
-------
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
-
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
-
T
H
P
D
Q
R
K
L
L
A
E
-
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
-----
D
S
P
VSQ
A
-
P
-
I
----------
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
--
G
G
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
-
V
-
G
---
L
D
E
L
VYR
R
-----
S
T
L
V
R
G
L
S
R
M
P
V
T
M
--
98
PsiBlast_CBE
74.52
34%
-132
- C6 -
3A51
5
CPVDH_PSEAH
C:
[10-398]
----------
Q
H
D
L
F
S
G
T
F
W
Q
----
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
KL---
A
L
P
D
------
G
-
P
V
W
L
L
T
------------
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-----------------------
L
---
S
K
D
----
W
RHRLPEDQRAD
M
P
--
A
--
T
-----
P
--------
T
-
P
--------
M
---------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
----
P
T
---
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
-
V
L
V
D
D
-----
S
P
A
D
-------------
D
K
N
A
A
M
G
--
K
L
H
G
Y
L
S
D
L
L
E
-------
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
-
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
-
T
H
P
D
Q
R
K
L
L
A
E
-
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
-----
D
S
P
VSQ
A
-
P
-
I
----------
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
--
G
G
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
-
V
-
G
---
L
D
E
L
VYR
R
-----
S
T
L
V
R
G
L
S
R
M
P
V
T
M
--
106
PsiBlast_CBE
74.47
34%
-127
- C6 -
3A4Z
4
CPVDH_PSEAH
E:
[10-398]
----------
Q
H
D
L
F
S
G
T
F
W
Q
----
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
KL---
A
L
P
D
------
G
-
P
V
W
L
L
T
------------
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-----------------------
L
---
S
K
D
----
W
RHRLPEDQRAD
M
P
--
A
--
T
-----
P
--------
T
-
P
--------
M
---------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
----
P
T
---
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
-
V
L
V
D
D
-----
S
P
A
D
-------------
D
K
N
A
A
M
G
--
K
L
H
G
Y
L
S
D
L
L
E
-------
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
-
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
-
T
H
P
D
Q
R
K
L
L
A
E
-
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
-----
D
S
P
VSQ
A
-
P
-
I
----------
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
--
G
G
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
-
V
-
G
---
L
D
E
L
VYR
R
-----
S
T
L
V
R
G
L
S
R
M
P
V
T
M
--
7
PsiBlast_PDB
74.35
37%
-121
- C6 -
2VZM
2
PIKC_STRVZ
A:
[38-424]
----------------
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
-----
T
P
E
G
------
N
-
E
V
W
L
V
V
------------
G
Y
D
R
A
R
A
V
L
A
D
PRFS
K
D
-----------------------
W
---
R
N
S
----
T
-----------
T
P
L
T
E
--
A
-----
E
--------
A
-
A
--------
L
N
H
N
------
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
AAP
D
G
---
R
A
---
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
-
F
-------
P
D
D
P
A
Q
A
Q
T
A
--
M
--------
A
--
E
M
S
G
Y
L
S
R
L
I
D
-------
S
K
R
G
Q
D
-
G
E
D
L
L
-
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
-
S
H
P
D
Q
L
A
A
L
R
A
-
D
-
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
-----
E
G
P
---
V
E
S
-
A
---
T
Y
-----
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
A
--
G
H
L
A
F
G
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
--
A
-
L
-
D
---
V
S
P
G
---
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---
92
PsiBlast_CBE
74.14
35%
-130
- C6 -
3A4G
2
CPVDH_PSEAH
A:
[10-398]
----------
Q
H
D
L
F
S
G
T
F
W
Q
----
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
K
L
---
A
L
P
D
------
G
-
P
V
W
L
L
T
------------
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-----------------------
L
SKD
W
R
H
----
T
-----------
L
P
--
E
D-
Q
-----
R
--------
A
-
D
--------
M
P
A
T
PTPM--
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
----
P
T
---
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
-
V
L
V
D
D
-----
S
P
A
D
-------------
D
K
N
A
A
M
G
--
K
L
H
G
Y
L
S
D
L
L
E
-------
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
-
S
D
E
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
-
T
H
P
D
Q
R
K
L
L
A
E
-
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
-----
D
S
P
VSQ
A
-
P
-
I
----------
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
--
G
G
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
-
V
-
G
---
L
D
E
L
V
Y
R
E
-----
S
T
L
V
R
G
L
S
R
M
P
V
T
M
--
103
PsiBlast_CBE
74.13
34%
-129
- C6 -
3A50
5
CPVDH_PSEAH
C:
[10-398]
----------
Q
H
D
L
F
S
G
T
F
W
Q
----
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
KL---
A
L
P
D
------
G
-
P
V
W
L
L
T
------------
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-----------------------
L
---
S
K
D
----
W
RHRLPEDQRAD
M
P
--
A
--
T
-----
P
--------
T
-
P
--------
M
---------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
----
P
T
---
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
-
V
L
V
D
D
-----
S
P
A
D
-------------
D
K
N
A
A
M
G
--
K
L
H
G
Y
L
S
D
L
L
E
-------
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
-
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
-
T
H
P
D
Q
R
K
L
L
A
E
-
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
-----
D
S
P
VSQ
A
-
P
-
I
----------
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
--
G
G
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
-
V
-
G
---
L
D
E
L
VYR
R
-----
S
T
L
V
R
G
L
S
R
M
P
V
T
M
--
46
PsiBlast_CBE
74.11
37%
-120
- C6 -
2CD8
2
PIKC_STRVZ
B:
[38-424]
----------------
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
AHR
V
R
-----
T
P
E
G
------
D
-
E
V
W
L
V
V
------------
G
Y
D
R
A
R
A
V
L
A
D
PRFS
K
D
-----------------------
W
---
R
N
S
----
T
-----------
T
P
LT
E
--
A
-----
E
--------
A
-
A
--------
L
N
H
N
------
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
LAAP
D
G
---
R
A
---
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
-
F
-------
P
D
D
P
A
Q
A
Q
T
A
--
M
--------
A
--
E
M
S
G
Y
L
S
R
L
I
D
-------
S
K
R
G
Q
D
-
G
E
D
L
L
-
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
-
S
H
P
D
Q
L
A
A
L
R
A
-
D
-
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
-----
E
G
P
---
V
E
S
-
A
---
T
Y
-----
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
A
--
G
H
L
A
F
G
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
--
A
-
L
-
D
---
V
S
P
G
---
E
LVWYP
N
P
M
I
R
G
L
K
A
L
P
I
R
---
48
PsiBlast_CBE
73.90
37%
-119
- C6 -
2C6H
3
PIKC_STRVZ
B:
[38-424]
----------------
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
AHR
V
R
-----
T
P
E
G
------
D
-
E
V
W
L
V
V
------------
G
Y
D
R
A
R
A
V
L
A
D
PRFS
K
D
-----------------------
W
---
R
N
S
----
T
-----------
T
P
LT
E
--
A
-----
E
--------
A
-
A
--------
L
N
H
N
------
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
LAAP
D
G
---
R
A
---
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
-
F
-------
P
D
D
P
A
Q
A
Q
T
A
--
M
--------
A
--
E
M
S
G
Y
L
S
R
L
I
D
-------
S
K
R
G
Q
D
-
G
E
D
L
L
-
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
-
S
H
P
D
Q
L
A
A
L
R
A
-
D
-
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
-----
E
G
P
---
V
E
S
-
A
---
T
Y
-----
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
A
--
G
H
L
A
F
G
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
--
A
-
L
-
D
---
V
S
P
G
---
E
LVWYP
N
P
M
I
R
G
L
K
A
L
P
I
R
---
107
PsiBlast_CBE
73.78
34%
-129
- C6 -
3A4Z
5
CPVDH_PSEAH
D:
[10-398]
----------
Q
H
D
L
F
S
G
T
F
W
Q
----
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
KL---
A
L
P
D
------
G
-
P
V
W
L
L
T
------------
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-----------------------
L
---
S
K
D
----
W
RHRLPEDQRAD
M
P
--
A
--
T
-----
P
--------
T
-
P
--------
M
---------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
----
P
T
---
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
-
V
L
V
D
D
-----
S
P
A
D
-------------
D
K
N
A
A
M
G
--
K
L
H
G
Y
L
S
D
L
L
E
-------
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
-
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
-
T
H
P
D
Q
R
K
L
L
A
E
-
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
-----
D
S
P
VSQ
A
-
P
-
I
----------
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
--
G
G
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
-
V
-
G
---
L
D
E
L
VYR
R
-----
S
T
L
V
R
G
L
S
R
M
P
V
T
M
--
102
PsiBlast_CBE
73.67
34%
-128
- C6 -
3A50
6
CPVDH_PSEAH
D:
[10-398]
----------
Q
H
D
L
F
S
G
T
F
W
Q
----
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
KL---
A
L
P
D
------
G
-
P
V
W
L
L
T
------------
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
-----------------------
L
---
S
K
D
----
W
RHRLPEDQRAD
M
P
--
A
--
T
-----
P
--------
T
-
P
--------
M
---------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
----
P
T
---
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
-
V
L
V
D
D
-----
S
P
A
D
-------------
D
K
N
A
A
M
G
--
K
L
H
G
Y
L
S
D
L
L
E
-------
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
-
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
-
T
H
P
D
Q
R
K
L
L
A
E
-
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
-----
D
S
P
VSQ
A
-
P
-
I
----------
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
--
G
G
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
-
V
-
G
---
L
D
E
L
VYR
R
-----
S
T
L
V
R
G
L
S
R
M
P
V
T
M
--
43
PsiBlast_CBE
73.62
37%
-119
- C6 -
2VZM
2
PIKC_STRVZ
B:
[38-424]
----------------
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
-----
T
P
E
G
------
N
-
E
V
W
L
V
V
------------
G
Y
D
R
A
R
A
V
L
A
D
PRFS
K
D
-----------------------
W
---
R
N
S
----
T
-----------
T
P
L
T
E
--
A
-----
E
--------
A
-
A
--------
L
N
H
N
------
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
AAP
D
G
---
R
A
---
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
-
F
-------
P
D
D
P
A
Q
A
Q
T
A
--
M
--------
A
--
E
M
S
G
Y
L
S
R
L
I
D
-------
S
K
R
G
Q
D
-
G
E
D
L
L
-
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
-
S
H
P
D
Q
L
A
A
L
R
A
-
D
-
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
-----
E
G
P
---
V
E
S
-
A
---
T
Y
-----
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
A
--
G
H
L
A
F
G
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
--
A
-
L
-
D
---
V
S
P
G
---
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---
42
PsiBlast_CBE
73.62
37%
-122
- C6 -
3ZK5
2
PIKC_STRVZ
B:
[38-424]
----------------
G
A
L
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
-----
T
P
E
G
------
N
-
E
V
W
L
V
V
------------
G
Y
D
R
A
R
A
V
L
A
D
PRFS
K
D
-----------------------
W
---
R
N
S
----
T
-----------
T
P
L
T
E
--
A
-----
E
--------
A
-
A
--------
L
N
H
N
------
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
AAP
D
G
---
R
A
---
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
-
A
F
V
-
F
-------
P
D
D
P
A
Q
A
Q
T
A
--
M
--------
A
--
E
M
S
G
Y
L
S
R
L
I
D
-------
S
K
R
G
Q
D
-
G
E
D
L
L
-
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
-
S
H
P
D
Q
L
A
A
L
R
A
-
D
-
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
-----
E
G
P
---
V
E
S
-
A
---
T
Y
-----
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
A
--
G
H
L
A
F
G
H
-
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
--
A
-
L
-
D
---
V
S
P
G
---
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
---
140
HHSearch
73.42
36%
-123
- C6 -
3A4G
2
CPVDH_PSEAH
A:
[19-398]
-----------------------
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
-----
K
L
A
L
PD----
G
-
P
V
W
L
L
T
------------
R
Y
A
D
V
R
E
A
F
V
D
----
P
R
L----------------------
S
---
K
D
W
----
R
-----------
H
T
LP
E
D-
Q
R----
A
DM------
P
A
T
--------
P
T
P
M
------
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
----
P
T
---
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
-
V
L
V
----------
D
D
---
S
P
A
-----
D
D
K
N
A
A
M
G
--
K
L
H
G
Y
L
S
D
L
L
E
-------
R
K
R
T
E
P
-
D
D
A
L
L
-
S
S
L
L
A
-
V
S
D
E
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
-
T
H
P
D
Q
R
K
L
L
A
E
-
D
-
P
S
L
I
S
S
A
V
E
E
F
L
R
F
-----
D
S
P
---
V
-
S
-
Q
A--
P
I
-----
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
S
--
G
G
V
F
F
G
H
-
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
-
L
A
V
-
G
LDE
L
V
Y
R
---
E
-----
S
T
L
V
R
G
L
S
R
M
P
V
T
M
--
2
PsiBlast_PDB
73.25
41%
-128
- C6 -
4YT3
3
?
A:
[14-382]
-----------------
K
T
R
T
E
-
E
F
S
P
Y
A
W
C
K
R
M
L
E
N
D
P
---
V
S
-----
Y
H
E
G
------
T
-
D
T
W
N
V
F
------------
K
Y
E
D
V
K
R
V
L
S
D
----
Y
K
-----------------------
H
---
F
S
S
----
V
-----------
R
K
-----------------------------------VPEKIQ
I
T
E
S
D
P
P
D
H
R
K
R
R
S
L
L
A
A
A
F
T
P
R
S
L
Q
N
W
E
P
R
I
Q
E
I
A
D
E
L
I
G
Q
M
----
D
G
----
T
E
-
I
D
I
V
A
S
L
A
S
P
L
P
I
I
V
M
A
D
L
M
G
V
P
S
K
D
R
L
L
F
K
K
W
V
D
T
L
F
L
-
P
-----
F
----
Q
E
E
V
D
K
L
------
K
Q
V
A
A
K
--
E
Y
Y
Q
Y
L
Y
P
I
V
V
-------
Q
K
R
L
N
P
-
A
D
D
I
I
-
S
D
L
L
K
-
S
E
V
-
D
G
E
M
F
T
D
D
E
V
V
R
T
T
M
L
I
L
G
A
G
V
E
T
T
S
H
L
L
A
N
S
F
Y
S
L
L
Y
D
D
K
E
V
Y
Q
E
L
H
E
-
N
-
L
D
L
V
P
Q
A
V
E
E
M
L
R
F
-----
R
F
N
---
L
-
I
-
K
---
L
D
-----
R
T
V
K
E
D
N
D
L
-
L
G
V
E
L
K
E
G
D
S
V
V
V
W
M
S
A
A
N
M
D
E
E
M
F
E
D
P
F
T
L
N
I
H
R
-
P
N
N
K-
K
H
L
T
F
G
N
-
G
P
H
F
C
L
G
A
P
L
A
R
L
E
A
K
I
A
L
T
A
F
L
K
K
F
K
H
I
E
-
A
-
V
----------------------------------
21
PsiBlast_CBE
72.84
41%
-131
- C6 -
4YT3
2
?
B:
[14-382]
-----------------
K
T
R
T
E
-
E
F
S
P
Y
A
W
C
K
R
M
L
E
N
D
P
---
V
S
-----
Y
H
E
G
------
T
-
D
T
W
N
V
F
------------
K
Y
E
D
V
K
R
V
L
S
D
----
Y
K
-----------------------
H
---
F
S
S
----
V
-----------
R
------------------------------------VPEKIQ
I
T
E
S
D
P
P
D
H
R
K
R
R
S
L
L
A
A
A
F
T
P
R
S
L
Q
N
W
E
P
R
I
Q
E
I
A
D
E
L
I
G
Q
M
----
D
G
---
G
T
E
-
I
D
I
V
A
S
L
A
S
P
L
P
I
I
V
M
A
D
L
M
G
V
P
S
K
D
R
L
L
F
K
K
W
V
D
T
L
F
L
-
P
-----
F
----
Q
E
E
V
D
K
L
------
K
Q
V
A
A
K
--
E
Y
Y
Q
Y
L
Y
P
I
V
V
-------
Q
K
R
L
N
P
-
A
D
D
I
I
-
S
D
L
L
K
-
S
E
V
-
D
G
E
M
F
T
D
D
E
V
V
R
T
T
M
L
I
L
G
A
G
V
E
T
T
S
H
L
L
A
N
S
F
Y
S
L
L
Y
D
D
K
E
V
Y
Q
E
L
H
E
-
N
-
L
D
L
V
P
Q
A
V
E
E
M
L
R
F
-----
R
F
N
---
L
-
I
-
K
---
L
D
-----
R
T
V
K
E
D
N
D
L
-
L
G
V
E
L
K
E
G
D
S
V
V
V
W
M
S
A
A
N
M
D
E
E
M
F
E
D
P
F
T
L
N
I
H
R
-
P
N
N
K-
K
H
L
T
F
G
N
-
G
P
H
F
C
L
G
A
P
L
A
R
L
E
A
K
I
A
L
T
A
F
L
K
K
F
K
H
I
E
-
A
-
V
----------------------------------
3
PsiBlast_PDB
72.30
37%
-128
- C6 -
4GGV
1
?
A:
[37-389]
-----------------------------
W
L
R
G
Q
R
P
E
S
P
---
V
V
-----
F
D
E
T
------
Q
-
G
V
W
N
V
Y
------------
G
Y
P
E
A
M
D
I
L
N
D
----
H
D
-----------------------
T
---
F
T
S
DLAH
L
-----------
L
P
--
V
--
S
-----
V
--------
D
-
A
PL------
L
E
G
D
------
M
S
Q
M
D
P
P
R
H
R
K
Y
R
Q
L
V
S
R
A
F
T
P
R
L
V
A
D
M
E
T
R
V
A
D
I
T
R
E
L
L
D
A
V
----
D
G
---
K
P
E
-
I
E
I
A
A
D
L
A
Y
P
L
P
V
I
V
I
A
E
L
L
G
V
P
A
G
D
R
D
L
F
K
K
W
A
D
-
D
I
I
-
E
G
F
SGF
S
F
L
D
T
S
G
Q
G
E
Q
-----
D
V
R
D
A
T
E
R
L
R
P
L
L
D
Y
M
A
G
H
V
T
-------
E
R
R
R
T
P
-
R
E
D
L
L
-
T
H
L
V
Q
-
A
E
V
-
D
G
E
R
L
T
D
N
E
I
V
N
V
A
N
I
L
L
V
T
G
H
I
T
T
T
M
T
L
G
N
T
V
L
C
L
D
-
A
D
P
E
V
A
A
K
V
R
A
-
D
-
R
S
L
V
P
G
A
I
E
E
A
L
R
V
-----
L
S
P
---
S
-
A
-
A
---
L
A
-----
R
G
T
S
R
E
V
E
V
-
A
G
T
V
I
P
K
D
Q
I
V
M
L
W
L
G
A
G
N
R
D
P
R
Q
F
T
D
P
E
V
Y
D
P
T
R
-
D
P
N
--
P
H
F
G
F
G
R
-
G
I
H
F
C
L
G
A
P
L
A
R
L
E
G
R
V
A
L
N
A
L
F
D
R
F
P
-----------------------------------------
65
PsiBlast_CBE
71.87
36%
-132
- C6 -
3WVS
8
?
A:
[49-381]
--------------------------------------------------------------
A
W
L
A
T
------------
R
Y
E
D
A
R
L
V
L
G
D
----
A
R
---------------------------
F
S
R
----
A
-----------
L
S
--
E
--
E
-----
H
DPPRARKF
N
-
A
--------
Q
A
K
S
------
M
F
N
M
D
A
P
D
H
T
R
L
R
R
L
I
S
K
A
F
T
I
R
R
V
E
E
L
R
P
K
V
H
D
L
A
H
R
L
I
D
D
M
----
L
A
---
K
G
E
P
A
D
L
V
A
D
Y
A
L
P
I
P
T
T
V
I
C
E
L
L
G
V
P
F
E
D
R
E
K
F
G
R
W
T
D
-
A
I
L
-
S
-----
T
S
T
L
N
P
E
E
G
R
V
K
--
R
M
E
----------
L
V
G
Y
I
G
G
I
I
A
-------
A
R
R
A
Q
P
-
A
D
D
L
I
-
S
G
M
I
E
-
A
R
D
-
V
Q
D
K
L
T
E
Q
E
L
L
D
H
C
I
G
L
L
I
A
G
H
E
T
T
A
S
Q
I
P
S
F
V
Y
A
L
L
-
D
Q
P
Q
H
W
K
R
L
L
D
-
D
-
P
E
L
I
P
S
A
V
E
E
L
F
R
F
VP---
L
G
S
---
G
-
S
-
A
---
A
P
-----
R
Y
A
R
E
D
I
E
V
-
G
G
T
L
V
R
A
G
E
P
V
L
V
A
L
G
A
A
N
R
D
G
L
R
F
E
D
P
E
E
I
K
L
D
R
-
P
S
N
--
H
H
I
G
F
G
H
-
G
I
H
H
C
L
G
A
P
L
A
R
L
E
L
Q
E
A
L
R
A
L
L
E
R
L
P
T
L
K
-
V
-
A
-
G
--------------------------------
121
HHSearch
71.07
33%
-131
- C6 -
4E2P
4
?
A:
[28-416]
------------------------
W
G
I
H
P
E
H
F
W
L
Y
G
R
R
P
---
R
Q
-----
M
V
E
F
D
EK---
M
-
N
A
W
N
V
Y
------------
G
Y
A
E
A
I
E
V
L
G
D
----
P
G
-----------------------
T
---
F
S
S
----
H
-----------
M
S
--
R
L-
L
----------------
F
--------
T
E
G
D
------
L
L
Q
T
D
P
P
D
H
R
E
L
R
K
L
V
S
H
A
F
T
P
K
V
V
A
E
L
E
P
R
I
T
A
L
T
Q
E
L
L
D
A
V
----
A
D
---
R
D
T
-
F
D
L
M
T
A
L
A
Y
P
L
P
V
T
V
V
A
E
L
L
S
I
P
S
A
D
R
H
L
F
E
G
W
M
T
-
E
I
V
-
H
-----
S
------------------
M
A
P
M
R
--
K
M
L
E
Y
L
R
E
H
A
A
-------
E
C
R
R
R
P
-
R
G
D
L
M
-
G
K
L
I
E
-
A
E
V
-
D
G
R
R
L
T
D
N
H
I
V
N
F
A
K
M
L
L
I
A
G
Y
L
T
T
T
M
L
I
G
N
T
V
L
C
L
D
-
S
Y
P
E
Q
A
A
R
V
R
A
-
D
-
R
S
L
I
P
G
L
L
E
E
S
M
R
F
-----
L
S
P
---
V
-
A
-
A
---
T
Y
-----
R
A
T
T
R
D
V
E
V
-
A
G
Q
R
L
S
A
D
Q
M
V
M
V
W
F
G
A
A
N
R
D
A
R
Q
F
A
E
P
E
L
F
D
M
T
R
-
G
P
N
--
P
H
L
G
F
G
R
-
G
I
H
F
C
L
G
G
P
L
A
R
M
E
G
R
V
A
L
D
H
L
L
D
R
F
-
P
E
L
-
Y
T
D
-
P
E
R
P
P
T
F
M
---
P
-----
G
F
D
T
T
G
V
S
S
L
P
L
R
T
--
139
HHSearch
70.74
33%
-106
- C6 -
2WM5
1
CP124_MYCTU
A:
[44-433]
------------------------
D
V
R
D
G
A
F
A
T
L
R
R
E
A
P
---
I
S
-----
F
W
P
T
IELVA
G
N
-
G
H
W
A
L
T
------------
K
Y
D
D
V
F
Y
A
S
R
H
----
P
D
-----------------------
I
---
F
S
S
----
Y
-----------
P
N
--
I
--
T
INDQT
P
E
-------
L
A
E
--------
Y
F
G
S
------
M
I
V
L
D
D
P
R
H
Q
R
L
R
S
I
V
S
R
A
F
T
P
K
V
V
A
R
I
E
A
A
V
R
D
R
A
H
R
L
V
S
S
M
----
I
A
N
N
P
D
R
Q
-
A
D
L
V
S
E
L
A
G
P
L
P
L
Q
I
I
C
D
M
M
G
I
P
K
A
D
H
Q
R
I
F
H
W
T
N
-
V
I
L
-
G
-----
F
G
D
P
D
----
L
A
T
--
D
F
D
E
F
M
Q
V
S
A
--
D
I
G
A
Y
A
T
A
L
A
E
-------
D
R
R
V
N
H
-
H
D
D
L
T
-
S
S
L
V
E
-
A
E
V
-
D
G
E
R
L
S
S
R
E
I
A
S
F
F
I
L
L
V
V
A
G
N
E
T
T
R
N
A
I
T
H
G
V
L
A
L
S
-
R
Y
P
E
Q
R
D
R
W
W
S
-
D
F
D
G
L
A
P
T
A
V
E
E
I
V
R
W
-----
A
S
P
---
V
-
V
-
Y
---
M
R
-----
R
T
L
T
Q
D
I
E
L
-
R
G
T
K
M
A
A
G
D
K
V
S
L
W
Y
C
S
A
N
R
D
E
S
K
F
A
D
P
W
T
F
D
L
A
R
-
N
P
N
--
P
H
L
G
F
G
G
G
G
A
H
F
C
L
G
A
N
L
A
R
R
E
I
R
V
A
F
D
E
L
R
R
Q
M
P
D
V
V
-
A
T
E
-
E
---
P
A
R
L
---
L
-----
S
Q
F
I
H
G
I
K
T
L
P
V
T
---
78
PsiBlast_CBE
70.66
37%
-126
- C6 -
2YCA
6
MYCG_MICGR
A:
[43-390]
------------------------------
Y
G
E
L
Q
E
T
E
P
---
V
S
R
V
R
P
P
Y
G
E
E
---------
A
W
L
V
T
------------
R
Y
E
D
V
R
A
V
L
G
D
----
G
R
-----------------------
F
---
V
R
G
-----------------
P
--
S
--
M
-----
T
--------
R
-
D
EPRTRPEM
V
K
G
G
------
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
----
A
A
---
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
-
A
F
L
-
S
-----
T
A
E
V
T
A
E
E
M
Q
E
A
----------
A
E
--
Q
A
Y
A
Y
M
G
D
L
I
D
-------
R
R
R
K
E
P
-
T
D
D
L
V
-
S
A
L
V
Q
-
A
R
D
-
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
-
T
R
P
E
L
R
R
Q
L
L
D
-
R
-
P
E
L
I
P
S
A
V
E
E
L
T
R
W
------
V
P
---
L
-
G
-
V
GTA
F
P
-----
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
--
Q
H
L
G
F
G
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
---------------------------------------
83
PsiBlast_CBE
70.44
37%
-124
- C6 -
2Y5N
7
MYCG_MICGR
B:
[43-390]
------------------------------
Y
G
E
L
Q
E
T
E
P
---
V
S
R
V
R
P
P
Y
G
E
E
---------
A
W
L
V
T
------------
R
Y
E
D
V
R
A
V
L
G
D
----
G
R
-----------------------
F
---
V
R
G
-----------------
P
--
S
--
M
-----
T
--------
R
-
D
EPRTRP
E
M
V
K
G
G
------
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
----
A
A
---
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
-
A
F
L
-
S
-----
T
A
E
V
T
A
E
E
M
Q
E
A
----------
A
E
--
Q
A
Y
A
Y
M
G
D
L
I
D
-------
R
R
R
K
E
P
-
T
D
D
L
V
-
S
A
L
V
Q
-
A
R
D
-
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
-
T
R
P
E
L
R
R
Q
L
L
D
-
R
-
P
E
L
I
P
S
A
V
E
E
L
T
R
W
------
V
P
---
L
-
G
-
V
GTA
F
P
-----
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
--
Q
H
L
G
F
G
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
---------------------------------------
85
PsiBlast_CBE
70.42
37%
-124
- C6 -
2Y46
5
MYCG_MICGR
C:
[43-390]
------------------------------
Y
G
E
L
Q
E
T
E
P
---
V
S
RVRPP
Y
G
E
E
---------
A
W
L
V
T
------------
R
Y
E
D
V
R
A
V
L
G
D
----
G
R
-----------------------
F
---
V
R
G
-----------------
P
--
S
--
M
-----
T
--------
R
-
D
EPRTRPEM
V
K
G
G
------
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
----
A
A
---
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
-
A
F
L
-
S
-----
T
A
E
V
T
A
E
E
M
Q
E
A
----------
A
E
--
Q
A
Y
A
Y
M
G
D
L
I
D
-------
R
R
R
K
E
P
-
T
D
D
L
V
-
S
A
L
V
Q
-
A
R
D
-
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
-
T
R
P
E
L
R
R
Q
L
L
D
-
R
-
P
E
L
I
P
S
A
V
E
E
L
T
R
W
------
V
P
---
L
-
G
-
V
GTA
F
P
-----
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
--
Q
H
L
G
F
G
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
---------------------------------------
71
PsiBlast_CBE
70.39
39%
-114
- C6 -
2WIO
1
ERYK_SACEN
A:
[53-394]
-----------------------------
W
L
G
T
M
R
E
K
Q
P
---
V
------
W
Q
D
R
------
Y
-
G
V
W
H
V
F
------------
R
H
A
D
V
Q
T
V
L
R
D
----
T
A
-----------------------
T
---
F
S
S
----
D
PTR--------
V
I
--
E
--
G
-----
A
--------
S
-
P
--------
T
P
G
M
------
I
H
E
I
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
V
T
R
S
L
L
A
D
-----
A
G
---
E
S
--
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
M
D
H
E
Q
F
G
D
W
S
G
-
A
L
V
-
D
-----
I
Q
M
D
--
D
P
T
D
P
A
--
L
A
E
R
I
A
D
V
L
N
--
P
L
T
A
Y
L
K
A
R
C
A
-------
E
R
R
A
D
P
-
G
D
D
L
I
-
S
R
L
V
L
-
A
E
V
-
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
R
T
L
D
-
E
H
P
A
H
W
D
A
A
A
E
-
D
-
P
G
R
I
P
A
I
V
E
E
V
L
R
Y
-----
R
P
P
---
F
-
P
-
Q
---
M
Q
-----
R
T
T
T
K
A
T
E
V
-
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
D
P
D
R
F
D
P
S
R
-
K
S
G
GA
A
Q
L
S
F
G
H
-
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
F
------------------------------------------
109
Fugue
70.02
37%
-132
- C6 -
1IO7
1
CP119_SULAC
A:
[1-366]
------------------------
M
--
Y
D
W
F
S
E
M
R
K
K
D
P
---
V
Y
-----
Y
D
G
---------
N
I
W
Q
V
F
------------
S
Y
R
Y
T
K
E
V
L
N
------
N
FSKFSSDLTGYHER
L
E
D
L
R
N
GKI
R
-----------------------------
F
-----
D
--------
I
-
P
--------
T
R
Y
T
------
M
L
T
S
D
P
P
L
H
D
E
L
R
S
M
S
A
D
I
F
S
P
Q
K
L
Q
T
L
E
T
F
I
R
E
T
T
R
S
L
L
D
S
I
----
D
P
----
R
E
-
D
D
I
V
K
K
L
A
V
P
L
P
I
I
V
I
S
K
I
L
G
L
P
I
E
D
K
E
K
F
K
E
W
S
D
-
L
V
A
-
F
-----
R
L
G
K
------
P
G
--
E
I
F
E
L
G
K
K
Y
L
--
E
L
I
G
Y
V
K
D
H
L
N
------------
S
G-
T
E
V
V
-
S
R
V
V
N
-
S
------
N
L
S
D
I
E
K
L
G
Y
I
I
L
L
L
I
A
G
N
E
T
T
T
N
L
I
S
N
S
V
I
D
F
T
-
R
F
N
-
L
W
Q
R
I
R
E
E
---
N
L
Y
L
K
A
I
E
E
A
L
R
Y
-----
S
P
P
---
V
-
M
R
T
----
V
-----
R
K
T
K
E
R
V
K
L
G-
D
Q
T
I
E
E
G
E
Y
V
R
V
W
I
A
S
A
N
R
D
E
E
V
F
H
D
G
E
K
F
I
P
D
R
N-
P
N
--
P
H
L
S
F
G
S
-
G
I
H
L
C
L
G
A
P
L
A
R
L
E
A
R
I
A
I
E
E
F
S
K
R
F
R
H
I
E
-
I
-
L
D
----
T
E
K
V
---
P
-----
N
E
V
L
N
G
Y
K
R
L
V
V
R
L
K
S
84
PsiBlast_CBE
69.96
37%
-122
- C6 -
2Y5N
9
MYCG_MICGR
A:
[43-390]
------------------------------
Y
G
E
L
Q
E
T
E
P
---
V
S
R
V
R
P
P
Y
G
E
E
---------
A
W
L
V
T
------------
R
Y
E
D
V
R
A
V
L
G
D
----
G
R
-----------------------
F
---
V
R
G
-----------------
P
--
S
--
M
-----
T
--------
R
-
D
EPRTRP
E
M
V
K
G
G
------
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
----
A
A
---
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
-
A
F
L
-
S
-----
T
A
E
V
T
A
E
E
M
Q
E
A
----------
A
E
--
Q
A
Y
A
Y
M
G
D
L
I
D
-------
R
R
R
K
E
P
-
T
D
D
L
V
-
S
A
L
V
Q
-
A
R
D
-
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
-
T
R
P
E
L
R
R
Q
L
L
D
-
R
-
P
E
L
I
P
S
A
V
E
E
L
T
R
W
------
V
P
---
L
-
G
-
V
GTA
F
P
-----
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
--
Q
H
L
G
F
G
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
---------------------------------------
80
PsiBlast_CBE
69.92
37%
-120
- C6 -
2Y5Z
6
MYCG_MICGR
C:
[43-390]
------------------------------
Y
G
E
L
Q
E
T
E
P
---
V
S
RVRPP
Y
G
E
E
---------
A
W
L
V
T
------------
R
Y
E
D
V
R
A
V
L
G
D
----
G
R
-----------------------
F
---
V
R
G
-----------------
P
--
S
--
M
-----
T
--------
R
-
D
EPRTRPEM
V
K
G
G
------
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
----
A
A
---
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
-
A
F
L
-
S
-----
T
A
E
V
T
A
E
E
M
Q
E
A
----------
A
E
--
Q
A
Y
A
Y
M
G
D
L
I
D
-------
R
R
R
K
E
P
-
T
D
D
L
V
-
S
A
L
V
Q
-
A
R
D
-
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
-
T
R
P
E
L
R
R
Q
L
L
D
-
R
-
P
E
L
I
P
S
A
V
E
E
L
T
R
W
------
V
P
---
L
-
G
-
V
GTA
F
P
-----
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
--
Q
H
L
G
F
G
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
---------------------------------------
79
PsiBlast_CBE
69.91
37%
-121
- C6 -
2Y98
7
MYCG_MICGR
A:
[43-390]
------------------------------
Y
G
E
L
Q
E
T
E
P
---
V
S
R
V
R
P
P
Y
G
E
E
---------
A
W
L
V
T
------------
R
Y
E
D
V
R
A
V
L
G
D
----
G
R
-----------------------
F
---
V
R
G
-----------------
P
--
S
--
M
-----
T
--------
R
-
D
EPRTRP
E
M
V
K
G
G
------
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
----
A
A
---
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
-
A
F
L
-
S
-----
T
A
E
V
T
A
E
E
M
Q
E
A
----------
A
E
--
Q
A
Y
A
Y
M
G
D
L
I
D
-------
R
R
R
K
E
P
-
T
D
D
L
V
-
S
A
L
V
Q
-
A
R
D
-
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
-
T
R
P
E
L
R
R
Q
L
L
D
-
R
-
P
E
L
I
P
S
A
V
E
E
L
T
R
W
------
V
P
---
L
-
G
-
V
GT
A
F
P
-----
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
--
Q
H
L
G
F
G
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
---------------------------------------
87
PsiBlast_CBE
69.87
37%
-121
- C6 -
2Y46
6
MYCG_MICGR
A:
[43-390]
------------------------------
Y
G
E
L
Q
E
T
E
P
---
V
S
R
V
R
P
P
Y
G
E
E
---------
A
W
L
V
T
------------
R
Y
E
D
V
R
A
V
L
G
D
----
G
R
-----------------------
F
---
V
R
G
-----------------
P
--
S
--
M
-----
T
--------
R
-
D
EPRTRP
E
M
V
K
G
G
------
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
----
A
A
---
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
-
A
F
L
-
S
-----
T
A
E
V
T
A
E
E
M
Q
E
A
----------
A
E
--
Q
A
Y
A
Y
M
G
D
L
I
D
-------
R
R
R
K
E
P
-
T
D
D
L
V
-
S
A
L
V
Q
-
A
R
D
-
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
-
T
R
P
E
L
R
R
Q
L
L
D
-
R
-
P
E
L
I
P
S
A
V
E
E
L
T
R
W
------
V
P
---
L
-
G
-
V
GTA
F
P
-----
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
--
Q
H
L
G
F
G
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
---------------------------------------
66
PsiBlast_CBE
69.80
39%
-116
- C6 -
3ZKP
2
ERYK_SACEN
A:
[33-374]
-----------------------------
W
L
G
T
M
R
E
K
Q
P
---
V
------
W
Q
D
R
------
Y
-
G
V
W
H
V
F
------------
R
H
A
D
V
Q
T
V
L
R
D
----
T
A
-----------------------
T
---
F
S
S
----
D
PTR--------
V
I
--
E
--
G
-----
A
--------
S
-
P
--------
T
P
G
A
------
I
H
E
I
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
V
T
R
S
L
L
A
D
-----
A
G
---
E
S
--
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
M
D
H
E
Q
F
G
D
W
S
G
-
A
L
V
-
D
-----
I
Q
M
D
--
D
P
T
D
P
A
--
L
A
E
R
I
A
D
V
L
N
--
P
L
T
A
Y
L
K
A
R
C
A
-------
E
R
R
A
D
P
-
G
D
D
L
I
-
S
R
L
V
L
-
A
E
V
-
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
R
T
L
D
-
E
H
P
A
H
W
D
A
A
A
E
-
D
-
P
G
R
I
P
A
I
V
E
E
V
L
R
Y
-----
R
P
P
---
F
-
P
-
Q
---
M
Q
-----
R
T
T
T
K
A
T
E
V
-
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
D
P
D
R
F
D
P
S
R
-
K
S
G
GA
A
Q
L
S
F
G
H
-
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
F
------------------------------------------
61
PsiBlast_CBE
69.79
36%
-116
- C6 -
3R9C
10
?
A:
[16-388]
-------
Q
G
L
L
L
Q
L
L
D
P
A
T
R
A
D
----
P
Y
P
I
Y
D
R
I
R
R
G
G
P
---
L
A
-----
L
P
E
A
------
N
L
A
V
F
S
S
F
S
D
C
D
D
V
L
R
HPSS
C
S
D
R
T
K
S
T
I
F
Q
----
R
Q
-----------------------
L
---
A
A
E
----
T
-----------
Q
P
--
R
--
P
-----
Q
--------
G
-
P
--------
A
--
S
------
F
L
F
L
D
P
P
D
H
T
R
L
R
G
L
V
S
K
A
F
A
P
R
V
I
K
R
L
E
P
E
I
T
A
L
V
D
Q
L
L
D
A
V
----
D
G
----
P
E
-
F
N
L
I
D
N
L
A
Y
P
L
P
V
A
V
I
C
R
L
L
G
V
P
I
E
D
E
P
K
F
S
R
A
S
A
-
L
L
A
-
A
-----
A
L
D
P
F
L
A
L
T
G
E
T
SD
L
F
D
E
Q
M
K
A
G
M
--
W
L
R
D
Y
L
R
A
L
I
D
-------
E
R
R
R
T
P
-
G
E
D
L
M
-
S
G
L
V
A
-
V
E
E
-
S
G
D
Q
L
T
E
D
E
I
I
A
T
C
N
L
L
L
I
A
G
H
E
T
T
V
N
L
I
A
N
A
A
L
A
M
L
-
R
T
P
G
Q
W
A
A
L
A
A
-
D
-
G
S
R
A
S
A
V
I
E
E
T
M
R
Y
-----
D
P
P
---
V
-
Q
-
L
---
V
S
-----
R
Y
A
G
D
D
L
T
I
-
G
T
H
T
V
P
K
G
D
T
M
L
L
L
L
A
A
A
H
R
D
P
T
I
V
G
A
P
D
R
F
D
P
D
R
-
A
Q
I
--
R
H
L
G
F
G
K
-
G
A
H
F
C
L
G
A
P
L
A
R
L
E
A
T
V
A
L
P
A
L
A
A
R
F
P
-----------------------------------------
94
PsiBlast_CBE
69.78
34%
-128
- C6 -
4Z5P
2
?
B:
[18-373]
---------------------
D
-
G
L
E
I
H
P
K
F
A
E
L
R
E
T
D
P
LAR
V
R
-----
L
P
Y
G
------
G
-
E
G
W
M
V
T
------------
R
Y
D
D
V
R
A
A
N
S
D
----
P
R
-----------------------
F
---
S
R
A
----
Q
-----------
I
G
--
E
--
D
-----
T
PRTTP----------------
D
T
------
I
L
S
L
D
P
P
E
H
T
R
L
R
R
L
L
S
K
A
F
T
A
R
R
M
G
A
M
Q
S
W
L
E
E
L
F
A
G
L
L
D
G
V
----
E
R
---
T
G
H
P
A
D
I
V
R
D
L
A
Q
P
F
T
I
A
V
I
C
R
L
L
G
V
P
Y
E
D
R
G
R
F
Q
H
W
S
E
-
V
I
M
-
S
-----
T
T
A
Y
S
K
E
E
A
V
S
A
----------
D
A
--
S
I
R
A
Y
L
A
D
L
V
S
-------
A
R
R
A
A
P
-
H
D
D
L
L
-
G
V
L
V
S
-
A
R
D
-
D
D
D
R
L
T
E
D
E
L
I
T
F
G
V
T
L
L
V
A
G
H
E
T
S
A
H
Q
L
G
N
M
V
Y
A
L
L
-
T
H
E
D
Q
L
S
L
L
R
E
-
Q
-
P
E
L
L
P
R
A
V
E
E
L
L
R
F
-----------
V
-
P
-
L
---
G
N
GVGNA
R
I
A
L
E
D
V
E
L
-
S
G
G
T
V
R
A
G
E
G
V
V
A
A
A
V
N
A
N
R
D
P
R
A
F
D
D
P
D
R
L
D
I
T
R
-
E
K
N
--
P
H
L
A
F
G
H
-
G
A
H
Y
C
L
G
A
Q
L
A
R
M
E
L
R
V
A
I
G
G
L
L
E
R
F
P
G
L
---------------------------------------
69
PsiBlast_CBE
69.76
39%
-114
- C6 -
2JJO
2
ERYK_SACEN
A:
[33-374]
-----------------------------
W
L
G
T
M
R
E
K
Q
P
---
V
------
W
Q
D
R
------
Y
-
G
V
W
H
V
F
------------
R
H
A
D
V
Q
T
V
L
R
D
----
T
A
-----------------------
T
---
F
S
S
----
D
PTR--------
V
I
--
E
--
G
-----
A
--------
S
-
P
--------
T
P
G
M
------
I
H
E
I
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
V
T
R
S
L
L
A
D
-----
A
G
---
E
S
--
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
M
D
H
E
Q
F
G
D
W
S
G
-
A
L
V
-
D
-----
I
Q
M
D
--
D
P
T
D
P
A
--
L
A
E
R
I
A
D
V
L
N
--
P
L
T
A
Y
L
K
A
R
C
A
-------
E
R
R
A
D
P
-
G
D
D
L
I
-
S
R
L
V
L
-
A
E
V
-
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
R
T
L
D
-
E
H
P
A
H
W
D
A
A
A
E
-
D
-
P
G
R
I
P
A
I
V
E
E
V
L
R
Y
-----
R
P
P
---
F
-
P
-
Q
---
M
Q
-----
R
T
T
T
K
A
T
E
V
-
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
D
P
D
R
F
D
P
S
R
-
K
S
G
GA
A
Q
L
S
F
G
H
-
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
F
------------------------------------------
72
PsiBlast_CBE
69.66
37%
-121
- C6 -
4AW3
8
MYCG_MICGR
B:
[43-390]
------------------------------
Y
G
E
L
Q
E
T
E
P
---
V
S
RVRPP
Y
G
E
E
---------
A
W
L
V
T
------------
R
Y
E
D
V
R
A
V
L
G
D
----
G
R
-----------------------
F
---
V
R
G
-----------------
P
--
S
--
M
-----
T
--------
R
-
D
EPRTRPEM
V
K
G
G
------
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
----
A
A
---
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
-
A
F
L
-
S
-----
T
A
E
V
T
A
E
E
M
Q
E
A
----------
A
E
--
Q
A
Y
A
Y
M
G
D
L
I
D
-------
R
R
R
K
E
P
-
T
D
D
L
V
-
S
A
L
V
Q
-
A
R
D
-
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
-
T
R
P
E
L
R
R
Q
L
L
D
-
R
-
P
E
L
I
P
S
A
V
E
E
L
T
R
W
------
V
P
---
L
-
G
-
V
GTA
V
P
-----
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
--
Q
H
L
G
F
G
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
---------------------------------------
73
PsiBlast_CBE
69.65
37%
-123
- C6 -
4AW3
8
MYCG_MICGR
A:
[43-390]
------------------------------
Y
G
E
L
Q
E
T
E
P
---
V
S
R
V
R
P
P
Y
G
E
E
---------
A
W
L
V
T
------------
R
Y
E
D
V
R
A
V
L
G
D
----
G
R
-----------------------
F
---
V
R
G
-----------------
P
--
S
--
M
-----
T
--------
R
-
D
EPRTRP
E
M
V
K
G
G
------
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
----
A
A
---
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
-
A
F
L
-
S
-----
T
A
E
V
T
A
E
E
M
Q
E
A
----------
A
E
--
Q
A
Y
A
Y
M
G
D
L
I
D
-------
R
R
R
K
E
P
-
T
D
D
L
V
-
S
A
L
V
Q
-
A
R
D
-
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
-
T
R
P
E
L
R
R
Q
L
L
D
-
R
-
P
E
L
I
P
S
A
V
E
E
L
T
R
W
------
V
P
---
L
-
G
-
V
GTA
V
P
-----
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
--
Q
H
L
G
F
G
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
---------------------------------------
86
PsiBlast_CBE
69.48
37%
-120
- C6 -
2Y46
5
MYCG_MICGR
B:
[43-390]
------------------------------
Y
G
E
L
Q
E
T
E
P
---
V
S
RVRPP
Y
G
E
E
---------
A
W
L
V
T
------------
R
Y
E
D
V
R
A
V
L
G
D
----
G
R
-----------------------
F
---
V
R
G
-----------------
P
--
S
--
M
-----
T
--------
R
-
D
EPRTRPEM
V
K
G
G
------
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
----
A
A
---
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
-
A
F
L
-
S
-----
T
A
E
V
T
A
E
E
M
Q
E
A
----------
A
E
--
Q
A
Y
A
Y
M
G
D
L
I
D
-------
R
R
R
K
E
P
-
T
D
D
L
V
-
S
A
L
V
Q
-
A
R
D
-
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
-
T
R
P
E
L
R
R
Q
L
L
D
-
R
-
P
E
L
I
P
S
A
V
E
E
L
T
R
W
------
V
P
---
L
-
G
-
V
GTA
F
P
-----
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
--
Q
H
L
G
F
G
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
---------------------------------------
95
PsiBlast_CBE
69.27
34%
-128
- C6 -
4Z5P
1
?
A:
[18-373]
---------------------
D
-
G
L
E
I
H
P
K
F
A
E
L
R
E
T
D
P
L
A
R
V
R
-----
L
P
Y
G
------
G
-
E
G
W
M
V
T
------------
R
Y
D
D
V
R
A
A
N
S
D
----
P
R
-----------------------
F
---
S
R
A
----
Q
-----------
I
G
--
E
--
D
-----
T
PRTTP----------------
D
T
------
I
L
S
L
D
P
P
E
H
T
R
L
R
R
L
L
S
K
A
F
T
A
R
R
M
G
A
M
Q
S
W
L
E
E
L
F
A
G
L
L
D
G
V
----
E
R
---
T
G
H
P
A
D
I
V
R
D
L
A
Q
P
F
T
I
A
V
I
C
R
L
L
G
V
P
Y
E
D
R
G
R
F
Q
H
W
S
E
-
V
I
M
-
S
-----
T
T
A
Y
S
K
E
E
A
V
S
A
----------
D
A
--
S
I
R
A
Y
L
A
D
L
V
S
-------
A
R
R
A
A
P
-
H
D
D
L
L
-
G
V
L
V
S
-
A
R
D
-
D
D
D
R
L
T
E
D
E
L
I
T
F
G
V
T
L
L
V
A
G
H
E
T
S
A
H
Q
L
G
N
M
V
Y
A
L
L
-
T
H
E
D
Q
L
S
L
L
R
E
-
Q
-
P
E
L
L
P
R
A
V
E
E
L
L
R
F
-----------
V
-
P
-
L
---
G
N
GV
G
N
A
R
I
A
L
E
D
V
E
L
-
S
G
G
T
V
R
A
G
E
G
V
V
A
A
A
V
N
A
N
R
D
P
R
A
F
D
D
P
D
R
L
D
I
T
R
-
E
K
N
--
P
H
L
A
F
G
H
-
G
A
H
Y
C
L
G
A
Q
L
A
R
M
E
L
R
V
A
I
G
G
L
L
E
R
F
P
G
L
---------------------------------------
81
PsiBlast_CBE
69.27
37%
-126
- C6 -
2Y5Z
7
MYCG_MICGR
B:
[43-390]
------------------------------
Y
G
E
L
Q
E
T
E
P
---
V
S
R
V
R
P
P
Y
G
E
E
---------
A
W
L
V
T
------------
R
Y
E
D
V
R
A
V
L
G
D
----
G
R
-----------------------
F
---
V
R
G
-----------------
P
--
S
--
M
-----
T
--------
R
-
D
EPRTRPEM
V
K
G
G
------
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
----
A
A
---
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
-
A
F
L
-
S
-----
T
A
E
V
T
A
E
E
M
Q
E
A
----------
A
E
--
Q
A
Y
A
Y
M
G
D
L
I
D
-------
R
R
R
K
E
P
-
T
D
D
L
V
-
S
A
L
V
Q
-
A
R
D
-
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
-
T
R
P
E
L
R
R
Q
L
L
D
-
R
-
P
E
L
I
P
S
A
V
E
E
L
T
R
W
------
V
P
---
L
-
G
-
V
GT
A
F
P
-----
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
--
Q
H
L
G
F
G
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
---------------------------------------
67
PsiBlast_CBE
69.27
39%
-114
- C6 -
2XFH
4
ERYK_SACEN
A:
[33-374]
-----------------------------
W
L
G
T
M
R
E
K
Q
P
---
V
------
W
Q
D
R
------
Y
-
G
V
W
H
V
F
------------
R
H
A
D
V
Q
T
V
L
R
D
----
T
A
-----------------------
T
---
F
S
S
----
D
PTR--------
V
I
--
E
--
G
-----
A
--------
S
-
P
--------
T
P
G
M
------
I
H
E
I
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
V
T
R
S
L
L
A
D
-----
A
G
---
E
S
--
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
M
D
H
E
Q
F
G
D
W
S
G
-
A
L
V
-
D
-----
I
Q
M
D
--
D
P
T
D
P
A
--
L
A
E
R
I
A
D
V
L
N
--
P
L
T
A
Y
L
K
A
R
C
A
-------
E
R
R
A
D
P
-
G
D
D
L
I
-
S
R
L
V
L
-
A
E
V
-
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
R
T
L
D
-
E
H
P
A
H
W
D
A
A
A
E
-
D
-
P
G
R
I
P
A
I
V
E
E
V
L
R
Y
-----
R
P
P
---
F
-
P
-
Q
---
M
Q
-----
R
T
T
T
K
A
T
E
V
-
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
D
P
D
R
F
D
P
S
R
-
K
S
G
GA
A
Q
L
S
F
G
H
-
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
F
------------------------------------------
88
PsiBlast_CBE
69.25
36%
-118
- C6 -
3ZSN
6
MYCG_MICGR
C:
[43-390]
------------------------------
Y
G
E
L
Q
E
T
E
P
---
V
S
RVRPP
Y
G
E
E
---------
A
W
L
V
T
------------
R
Y
E
D
V
R
A
V
L
G
D
----
G
R
-----------------------
F
---
V
R
G
-----------------
P
--
S
--
M
-----
T
--------
R
-
D
EPRTRPEM
V
K
G
G
------
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
----
A
A
---
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
-
A
F
L
-
S
-----
T
A
E
V
T
A
E
E
M
Q
E
A
----------
A
E
--
Q
A
Y
A
Y
M
G
D
L
I
D
-------
R
R
R
K
E
P
-
T
D
D
L
V
-
S
A
L
V
Q
-
A
R
D
-
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
-
T
R
P
E
L
R
R
Q
L
L
D
-
R
-
P
E
L
I
P
S
A
V
E
E
L
T
R
W
VPLGV
G
T
A
---
A
-
P
------------
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
--
Q
H
L
G
F
G
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
---------------------------------------
90
PsiBlast_CBE
69.15
36%
-119
- C6 -
3ZSN
7
MYCG_MICGR
A:
[43-390]
------------------------------
Y
G
E
L
Q
E
T
E
P
---
V
S
R
V
R
P
P
Y
G
E
E
---------
A
W
L
V
T
------------
R
Y
E
D
V
R
A
V
L
G
D
----
G
R
-----------------------
F
---
V
R
G
-----------------
P
--
S
--
M
-----
T
--------
R
-
D
EPRTRP
E
M
V
K
G
G
------
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
----
A
A
---
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
-
A
F
L
-
S
-----
T
A
E
V
T
A
E
E
M
Q
E
A
----------
A
E
--
Q
A
Y
A
Y
M
G
D
L
I
D
-------
R
R
R
K
E
P
-
T
D
D
L
V
-
S
A
L
V
Q
-
A
R
D
-
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
-
T
R
P
E
L
R
R
Q
L
L
D
-
R
-
P
E
L
I
P
S
A
V
E
E
L
T
R
W
VPLGV
G
T
A
---
A
-
P
------------
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
--
Q
H
L
G
F
G
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
---------------------------------------
63
PsiBlast_CBE
68.94
36%
-122
- C6 -
3R9B
11
?
B:
[16-388]
-------
Q
G
L
L
L
Q
L
L
D
P
A
T
R
A
D
----
P
Y
P
I
Y
D
R
I
R
R
G
G
P
---
L
A
-----
L
P
E
A
------
N
L
A
V
F
S
S
F
SDCDDVLRHPSS
C
S
D
R
T
K
S
T
I
F
Q
----
R
Q
-----------------------
L
---
A
------------------------------------------
P
--------
A
--
S
------
F
L
F
L
D
P
P
D
H
T
R
L
R
G
L
V
S
K
A
F
A
P
R
V
I
K
R
L
E
P
E
I
T
A
L
V
D
Q
L
L
D
A
V
----
D
G
----
P
E
-
F
N
L
I
D
N
L
A
Y
P
L
P
V
A
V
I
C
R
L
L
G
V
P
I
E
D
E
P
K
F
S
R
A
S
A
-
L
L
A
-
A
-----
A
L
D
P
F
L
A
L
T
G
E
T
SD
L
F
D
E
Q
M
K
A
G
M
--
W
L
R
D
Y
L
R
A
L
I
D
-------
E
R
R
R
T
P
-
G
E
D
L
M
-
S
G
L
V
A
-
V
E
E
-
S
G
D
Q
L
T
E
D
E
I
I
A
T
C
N
L
L
L
I
A
G
H
E
T
T
V
N
L
I
A
N
A
A
L
A
M
L
-
R
T
P
G
Q
W
A
A
L
A
A
-
D
-
G
S
R
A
S
A
V
I
E
E
T
M
R
Y
-----
D
P
P
---
V
-
Q
-
L
---
V
S
-----
R
Y
A
G
D
D
L
T
I
-
G
T
H
T
V
P
K
G
D
T
M
L
L
L
L
A
A
A
H
R
D
P
T
I
V
G
A
P
D
R
F
D
P
D
R
-
A
Q
I
--
R
H
L
G
F
G
K
-
G
A
H
F
C
L
G
A
P
L
A
R
L
E
A
T
V
A
L
P
A
L
A
A
R
F
P
-----------------------------------------
89
PsiBlast_CBE
68.85
36%
-121
- C6 -
3ZSN
6
MYCG_MICGR
B:
[43-390]
------------------------------
Y
G
E
L
Q
E
T
E
P
---
V
S
RVRPP
Y
G
E
E
---------
A
W
L
V
T
------------
R
Y
E
D
V
R
A
V
L
G
D
----
G
R
-----------------------
F
---
V
R
G
-----------------
P
--
S
--
M
-----
T
--------
R
-
D
EPRTRPEM
V
K
G
G
------
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
----
A
A
---
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
-
A
F
L
-
S
-----
T
A
E
V
T
A
E
E
M
Q
E
A
----------
A
E
--
Q
A
Y
A
Y
M
G
D
L
I
D
-------
R
R
R
K
E
P
-
T
D
D
L
V
-
S
A
L
V
Q
-
A
R
D
-
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
-
T
R
P
E
L
R
R
Q
L
L
D
-
R
-
P
E
L
I
P
S
A
V
E
E
L
T
R
W
VPLGV
G
T
A
---
A
-
P
------------
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
--
Q
H
L
G
F
G
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
---------------------------------------
82
PsiBlast_CBE
68.84
37%
-121
- C6 -
2Y5Z
8
MYCG_MICGR
A:
[43-390]
------------------------------
Y
G
E
L
Q
E
T
E
P
---
V
S
R
V
R
P
P
Y
G
E
E
---------
A
W
L
V
T
------------
R
Y
E
D
V
R
A
V
L
G
D
----
G
R
-----------------------
F
---
V
R
G
-----------------
P
--
S
--
M
-----
T
--------
R
-
D
EPRTRPEM
V
K
G
G
------
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
M
----
A
A
---
T
G
Q
P
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
-
A
F
L
-
S
-----
T
A
E
V
T
A
E
E
M
Q
E
A
----------
A
E
--
Q
A
Y
A
Y
M
G
D
L
I
D
-------
R
R
R
K
E
P
-
T
D
D
L
V
-
S
A
L
V
Q
-
A
R
D
-
Q
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
-
T
R
P
E
L
R
R
Q
L
L
D
-
R
-
P
E
L
I
P
S
A
V
E
E
L
T
R
W
------
V
P
---
L
-
G
-
V
GTA
F
P
-----
R
Y
A
V
E
D
V
T
L
-
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
-
T
P
N
--
Q
H
L
G
F
G
H
-
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
---------------------------------------
70
PsiBlast_CBE
68.76
39%
-107
- C6 -
2JJN
5
ERYK_SACEN
A:
[33-374]
-----------------------------
W
L
G
T
M
R
E
K
Q
P
---
V
------
W
Q
D
R
------
Y
-
G
V
W
H
V
F
------------
R
H
A
D
V
Q
T
V
L
R
D
----
T
A
-----------------------
T
---
F
S
S
----
D
PTR--------
V
I
--
E
--
G
-----
A
--------
S
-
P
--------
T
P
G
M
------
I
H
E
I
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
V
T
R
S
L
L
A
D
-----
A
G
---
E
S
--
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
M
D
H
E
Q
F
G
D
W
S
G
-
A
L
V
-
D
-----
I
Q
M
D
--
D
P
T
D
P
A
--
L
A
E
R
I
A
D
V
L
N
--
P
L
T
A
Y
L
K
A
R
C
A
-------
E
R
R
A
D
P
-
G
D
D
L
I
-
S
R
L
V
L
-
A
E
V
-
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
R
T
L
D
-
E
H
P
A
H
W
D
A
A
A
E
-
D
-
P
G
R
I
P
A
I
V
E
E
V
L
R
Y
-----
R
P
P
---
F
-
P
-
Q
---
M
Q
-----
R
T
T
T
K
A
T
E
V
-
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
D
P
D
R
F
D
P
S
R
-
K
S
G
GA
A
Q
L
S
F
G
H
-
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
F
------------------------------------------
62
PsiBlast_CBE
68.66
36%
-122
- C6 -
3R9B
5
?
C:
[16-388]
-------
Q
G
L
L
L
Q
L
L
D
P
A
T
R
A
D
----
P
Y
P
I
Y
D
R
I
R
R
G
G
P
---
L
A
-----
L
P
E
A
------
N
L
A
V
F
S
S
F
SDCDDVLRHPSS
C
S
D
R
T
K
S
T
I
F
Q
----
R
Q
-----------------------
L
---
A
------------------------------------------
P
--------
A
--
S
------
F
L
F
L
D
P
P
D
H
T
R
L
R
G
L
V
S
K
A
F
A
P
R
V
I
K
R
L
E
P
E
I
T
A
L
V
D
Q
L
L
D
A
V
----
D
G
----
P
E
-
F
N
L
I
D
N
L
A
Y
P
L
P
V
A
V
I
C
R
L
L
G
V
P
I
E
D
E
P
K
F
S
R
A
S
A
-
L
L
A
-
A
-----
A
L
D
P
F
L
A
L
T
G
E
T
SD
L
F
D
E
Q
M
K
A
G
M
--
W
L
R
D
Y
L
R
A
L
I
D
-------
E
R
R
R
T
P
-
G
E
D
L
M
-
S
G
L
V
A
-
V
E
E
-
S
G
D
Q
L
T
E
D
E
I
I
A
T
C
N
L
L
L
I
A
G
H
E
T
T
V
N
L
I
A
N
A
A
L
A
M
L
-
R
T
P
G
Q
W
A
A
L
A
A
-
D
-
G
S
R
A
S
A
V
I
E
E
T
M
R
Y
-----
D
P
P
---
V
-
Q
-
L
---
V
S
-----
R
Y
A
G
D
D
L
T
I
-
G
T
H
T
V
P
K
G
D
T
M
L
L
L
L
A
A
A
H
R
D
P
T
I
V
G
A
P
D
R
F
D
P
D
R
-
A
Q
I
--
R
H
L
G
F
G
K
-
G
A
H
F
C
L
G
A
P
L
A
R
L
E
A
T
V
A
L
P
A
L
A
A
R
F
P
-----------------------------------------
68
PsiBlast_CBE
68.35
39%
-113
- C6 -
2JJP
3
ERYK_SACEN
A:
[33-374]
-----------------------------
W
L
G
T
M
R
E
K
Q
P
---
V
------
W
Q
D
R
------
Y
-
G
V
W
H
V
F
------------
R
H
A
D
V
Q
T
V
L
R
D
----
T
A
-----------------------
T
---
F
S
S
----
D
PTR--------
V
I
--
E
--
G
-----
A
--------
S
-
P
--------
T
P
G
M
------
I
H
E
I
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
V
T
R
S
L
L
A
D
-----
A
G
---
E
S
--
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
M
D
H
E
Q
F
G
D
W
S
G
-
A
L
V
-
D
-----
I
Q
M
D
--
D
P
T
D
P
A
--
L
A
E
R
I
A
D
V
L
N
--
P
L
T
A
Y
L
K
A
R
C
A
-------
E
R
R
A
D
P
-
G
D
D
L
I
-
S
R
L
V
L
-
A
E
V
-
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
R
T
L
D
-
E
H
P
A
H
W
D
A
A
A
E
-
D
-
P
G
R
I
P
A
I
V
E
E
V
L
R
Y
-----
R
P
P
---
F
-
P
-
Q
---
M
Q
-----
R
T
T
T
K
A
T
E
V
-
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
D
P
D
R
F
D
P
S
R
-
K
S
G
GA
A
Q
L
S
F
G
H
-
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
F
------------------------------------------
64
PsiBlast_CBE
68.19
36%
-123
- C6 -
3R9B
9
?
A:
[16-388]
-------
Q
G
L
L
L
Q
L
L
D
P
A
T
R
A
D
----
P
Y
P
I
Y
D
R
I
R
R
G
G
P
---
L
A
-----
L
P
E
A
------
N
L
A
V
F
S
S
F
S
D
C
D
D
V
L
R
HPSS
C
S
D
R
T
K
S
T
I
F
Q
----
R
Q
-----------------------
L
---
A
------------------------------------------
P
--------
A
--
S
------
F
L
F
L
D
P
P
D
H
T
R
L
R
G
L
V
S
K
A
F
A
P
R
V
I
K
R
L
E
P
E
I
T
A
L
V
D
Q
L
L
D
A
V
----
D
G
----
P
E
-
F
N
L
I
D
N
L
A
Y
P
L
P
V
A
V
I
C
R
L
L
G
V
P
I
E
D
E
P
K
F
S
R
A
S
A
-
L
L
A
-
A
-----
A
L
D
P
F
L
A
L
T
G
E
T
SD
L
F
D
E
Q
M
K
A
G
M
--
W
L
R
D
Y
L
R
A
L
I
D
-------
E
R
R
R
T
P
-
G
E
D
L
M
-
S
G
L
V
A
-
V
E
E
-
S
G
D
Q
L
T
E
D
E
I
I
A
T
C
N
L
L
L
I
A
G
H
E
T
T
V
N
L
I
A
N
A
A
L
A
M
L
-
R
T
P
G
Q
W
A
A
L
A
A
-
D
-
G
S
R
A
S
A
V
I
E
E
T
M
R
Y
-----
D
P
P
---
V
-
Q
-
L
---
V
S
-----
R
Y
A
G
D
D
L
T
I
-
G
T
H
T
V
P
K
G
D
T
M
L
L
L
L
A
A
A
H
R
D
P
T
I
V
G
A
P
D
R
F
D
P
D
R
-
A
Q
I
--
R
H
L
G
F
G
K
-
G
A
H
F
C
L
G
A
P
L
A
R
L
E
A
T
V
A
L
P
A
L
A
A
R
F
P
-----------------------------------------
19
PsiBlast_PDB
68.07
36%
-136
- C6 -
4E2P
4
?
A:
[36-390]
-----------------------------
W
L
Y
G
R
R
P
R
Q
M
---
V
E
-----
F
D
E
K
------
M
-
N
A
W
N
V
Y
------------
G
Y
A
E
A
I
E
V
L
G
D
----
P
G
-----------------------
T
---
F
S
S
----
H
-----------
M
S
--
R
LL-----------------
F
--------
T
E
G
D
------
L
L
Q
T
D
P
P
D
H
R
E
L
R
K
L
V
S
H
A
F
T
P
K
V
V
A
E
L
E
P
R
I
T
A
L
T
Q
E
L
L
D
A
V
----
A
D
---
R
D
T
-
F
D
L
M
T
A
L
A
Y
P
L
P
V
T
V
V
A
E
L
L
S
I
P
S
A
D
R
H
L
F
E
G
W
M
T
-
E
I
V
-
H
-----
S
---------------------------
M
A
P
M
R
K
M
L
E
Y
L
R
E
H
A
A
E
C
R
R
R
P
-
R
G
D
L
M
-
G
K
L
I
E
-
A
E
V
-
D
G
R
R
L
T
D
N
H
I
V
N
F
A
K
M
L
L
I
A
G
Y
L
T
T
T
M
L
I
G
N
T
V
L
C
L
D
-
S
Y
P
E
Q
A
A
R
V
R
A
-
D
-
R
S
L
I
P
G
L
L
E
E
S
M
R
F
-----
L
S
P
---
V
-
A
-
A
---
T
Y
-----
R
A
T
T
R
D
V
E
V
-
A
G
Q
R
L
S
A
D
Q
M
V
M
V
W
F
G
A
A
N
R
D
A
R
Q
F
A
E
P
E
L
F
D
M
T
R
-
G
P
N
--
P
H
L
G
F
G
R
-
G
I
H
F
C
L
G
G
P
L
A
R
M
E
G
R
V
A
L
D
H
L
L
D
R
F
P
E
L
---------------------------------------