@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu18370: (2016-06-29 )
METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGMMAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGTTLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYTTFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFLVLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFVNHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWLNYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMRASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQFVWKKKQITRLIQ
Atome Classification :
(20 SA)
.........10........20........30........40...-------.....50--.........60........70........80........90........100.......110....-----..--.120..--......130.......140.......150.......160.......170.......180.......190.......200.......210.......220...-....230.......240.......250.......260.......270..-.-....-280-.-......290.......300.......310.......320.......330.......340.......350.......360..---.....370-........380-.........-390..-.....400....-----...410.......420-----..-----.-----......430.......440.......450.......460.---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
METSQEPLVTQKKSK
P
S
V
W
R
S
M
S
L
F
L
V
P
L
L
L
S
N
V
L
Q
S
V
G
Q
L
V
G
M
-------
M
A
V
G
R
W
---L
G
V
D
A
V
A
A
V
S
S
F
F
P
L
F
F
L
L
I
S
F
T
I
GIGSG
S
S
I
L
I
G
QAYGAK
N
E
E
R
L
K
A
V
VG
T
T
L
T
F
T
F
L
L
G
V
V
L
A
V
-----
I
G
--
S
I
F
-
T
L
--
D
I
L
R
L
MGTPE
N
V
I
H
VSA
N
Y
A
R
I
L
F
Y
A
M
P
F
M
F
L
Y
F
A
Y
T
T
F
LRGTGDSKT
P
F
Y
T
L
I
V
S
T
V
I
N
I
A
L
L
P
V
L
I
L
G
MFGFPKLGIY
G
S
A
Y
A
T
V
I
S
T
I
A
T
F
L
V
L
M
V
Y
L
R
-KRKHPL
Q
F
D
K
T
V
R
R
Y
L
KM
D
K
E
L
L
V
L
L
L
R
LGVPAS
I
N
M
I
L
V
S
L
S
E
I
A
V
I
S
-
F
-
V
N
HY-GSN-
A
-
T
A
A
Y
G
V
V
N
Q
V
A
S
Y
V
QM
P
A
V
S
L
G
I
A
V
S
I
F
A
A
QSIG
A
N
E
F
D
R
L
K
Q
V
I
R
V
G
I
W
L
N
Y
I
I
G
G
V
L
I
I
L
I
Y
V
F
S
H
Q
I
L
S
L
F
LTEQ
E
T
L
---
Y
I
A
H
R
L
L
--
M
I
T
L
W
S
Y
L
L
---FGN
A
Q
I
I
S
A
-
T
MRAS-G
T
V
L
W
P
T
V
I
S
I
F
-----
A
I
WGVE
V
P
V
A
F
V
L
S
-------
H
Y-----
T
-----
K
L
E
I
L
G
V
WVG
Y
P
A
A
F
A
V
S
L
L
L
I
Y
G
Y
Y
Q
F
V
W
K
K
K
Q
I
T
R
LIQ---
12
PsiBlast_PDB
76.41
24%
-
- C4 -
4LZ9
1
?
A:
[11-431]
------------
E
A
I
P
K
L
L
R
S
L
S
---
I
P
A
M
I
G
M
F
V
M
A
L
Y
N
V
V
D
T
-------
I
F
I
S
Y
A
---
V
G
I
E
G
V
A
G
V
T
I
A
F
P
I
M
M
I
M
M
S
M
A
G
A
L
G
I
G
G
A
S
V
I
S
R
R
L
G
E
R
R
G
E
E
A
N
Q
V
F
G
N
I
L
T
V
I
----
L
V
L
S
V
-----
I
G
F
I
S
A
F
-
T
L
L
G
P
A
L
Q
L
F
G
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V
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Y
A
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Y
L
F
P
I
L
L
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F
F
F
F
A
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A
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N
N
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N
A
T
F
A
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V
T
M
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P
A
V
L
N
I
L
L
D
V
L
F
I
F
G
L
----
N
M
G
V
L
G
A
S
I
A
T
V
I
A
Q
A
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V
T
G
L
V
L
R
Y
F
L
-
T
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K
S
T
L
S
L
H
W
S
---
D
L
R
M
K
G
S
V
I
K
E
V
C
L
V
G
L
P
A
F
V
Q
Q
S
S
A
S
L
M
M
I
A
I
N
S
-
M
-
L
L
R
F
-
G
S
D
F
Y
-
V
G
V
F
G
L
V
Q
R
I
M
M
F
V
M
M
P
M
M
G
I
M
Q
A
M
Q
P
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G
Y
N
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G
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K
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R
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L
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L
F
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T
A
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R
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V
I
---
Q
A
G
V
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A
M
--
H
I
L
F
C
V
T
F
L
---
I
G
-
A
Q
I
V
A
G
-
G
L
Y
Q
S
L
G
K
P
K
Q
A
L
I
L
S
L
S
-----
R
Q
I
I
F
L
I
P
L
V
L
I
L
P
-------
H
I
-----
F
-----
G
L
S
--
G
V
W
W
A
F
P
I
A
D
V
L
S
F
I
L
----------------------
25
HHSearch
75.77
23%
-160
- C4 -
3W4T
9
?
A:
[14-444]
---------------
G
D
P
K
K
A
I
V
R
L
S
I
A
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
-------
I
W
V
S
G
----
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
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L
G
V
G
T
S
S
A
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A
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R
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K
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G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
-----
T
M
--
L
P
A
-
I
D
--
S
L
F
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
T
----
L
G
F
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
W
L
F
V
K
R
D
T
Y
V
D
I
T
L
---
R
D
F
S
P
S
R
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
-
V
-
A
I
T
A
G
G
E
N
-
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
-----VI
K
G
D
L
I
S
A
L
--
R
T
L
P
V
F
L
V
L
---
T
P
F
G
M
M
T
S
A
-
M
F
Q
G
I
-
G
E
G
E
K
S
L
I
L
T
I
F
-----
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
-------
H
Y
-----
T
-----
T
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
G
F
L
W
G
-----------------
2
PsiBlast_PDB
73.67
25%
-127
- C4 -
3VVN
12
?
A:
[25-451]
--------------------------
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
-----------
A
D
G
I
W
V
S
G
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
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A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
P
A
I
D
--
S
L
F
--------
R
S
M
G
A
--
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
-
T
L
G
F
---
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
W
L
F
-
V
K
R
D
T
-
Y
V
D
I
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L
R
D
F
-
S
P
S
R
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
-
V
A
I
T
A
G
-
G
E
N
-
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
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A
V
V
A
F
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M
L
F
A
P
Q
V
A
Y
L
F
T
----
A
Q
---
V
I
K
G
D
L
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
--
M
M
T
S
A
-
M
F
Q
G
I
-
G
E
G
E
K
S
L
I
L
T
I
F
-----
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
-------
H
Y
-----
T
-----
T
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
-----
G
F
L
W
G
R
M
R
I
S
A
L
-----
4
PsiBlast_PDB
73.44
25%
-125
- C4 -
3VVP
1
?
A:
[25-451]
--------------------------
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
-----------
A
D
G
I
W
V
SG
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
PA
I
D
--
S
L
F
--------
R
-------
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
G
I
L
R
G
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G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
-
T
L
G
F
---
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
W
L
F
-
V
K
R
D
T
-
Y
V
D
I
---
D
F
-
S
P
S
R
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L
K
D
I
L
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V
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L
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S
L
S
Q
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M
S
I
A
M
F
F
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N
S
-
V
A
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T
A
G
-
G
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N
-
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
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K
L
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A
Y
L
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A
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K
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M
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A
V
V
A
F
I
M
L
-----------------------
D
L
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
--
M
M
T
S
A
-
M
F
Q
G
I
-
G
E
G
E
K
S
L
I
L
T
I
F
-----
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
-------
H
Y
-----
T
-----
T
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
-----
G
F
L
W
G
R
M
R
I
S
A
L
-----
1
PsiBlast_PDB
73.38
25%
-126
- C4 -
4MLB
22
?
A:
[32-458]
--------------------------
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
-----------
A
D
G
I
W
V
S
G
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
-----
T
M
--
L
P
A
-
I
D
--
S
L
F
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
-
T
L
G
F
---
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
W
L
F
-
V
K
R
D
T
-
Y
V
D
I
T
L
R
D
F
-
S
P
S
R
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
-
V
A
I
T
A
G
-
G
E
N
-
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
T
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
S
E
S
A
Q
---
V
I
K
G
D
L
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
--
M
M
T
S
A
-
M
F
Q
G
I
-
G
E
G
E
K
S
L
I
L
T
I
F
-----
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
-------
H
Y
-----
T
-----
T
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
-----
G
F
L
W
G
R
M
R
I
S
A
L
-----
31
Fugue
72.46
21%
-145
- C4 -
3MKT
-
?
A:
[2-461]
--------
E
N
S
V
H
R
Y
K
K
E
A
S
N
L
I
K
L
A
T
P
V
L
I
A
S
V
A
Q
T
G
M
G
F
V
D
T
-------
I
M
A
G
G
V
---
S
A
I
D
-
M
A
A
V
S
I
A
A
S
I
W
L
P
S
I
L
F
G
V
G
L
L
M
A
L
V
P
V
V
A
Q
L
N
G
A
G
R
Q
H
K
I
P
F
E
V
H
Q
G
L
I
L
A
L
L
V
S
V
P
I
I
A
-----
V
L
--
F
Q
T
-
Q
---
F
I
I
R
F
M
D
V
E
E
A
M
A
T
K
T
V
G
Y
M
H
A
V
I
F
A
V
P
A
Y
L
L
F
Q
A
L
R
S
F
T
D
G
M
S
L
T
K
P
A
M
V
I
G
F
I
G
L
L
L
N
I
P
L
N
W
I
F
V
Y
G
K
F
G
A
P
E
L
G
G
V
G
C
G
V
A
T
A
I
V
Y
W
I
M
L
L
L
L
L
F
Y
I
V
-
T
S
K
R
L
A
H
V
K
V
F
-
E
T
F
H
K
P
Q
P
K
E
L
I
R
L
F
R
L
G
F
P
V
A
A
A
L
F
F
E
V
T
L
F
A
V
V
A
L
-
L
-
V
A
P
L
-
G
S
T
-
V
-
V
A
A
H
Q
V
A
L
N
F
S
S
L
V
F
M
F
P
M
S
I
G
A
A
V
S
I
R
V
G
H
K
L
G
E
Q
D
T
K
G
A
A
I
A
A
N
V
G
L
M
T
G
L
A
T
A
C
I
T
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
T
E
N
Q
V
V
V
---
A
L
A
M
Q
L
L
--
L
F
A
A
I
Y
Q
C
M
---
D
A
V
Q
V
V
A
A
G
-
S
L
R
G
Y
-
K
D
M
T
A
I
F
H
R
T
F
I
-----
S
Y
W
V
L
G
L
P
T
G
Y
I
L
G
-------
M
T
NWLTE
Q
-----
P
L
G
A
K
G
F
W
L
G
F
I
I
G
L
S
A
A
A
L
M
L
G
Q
R
L
Y
W
L
Q
K
Q
S
D
D
V
Q
L
H
L
A
A
K
7
PsiBlast_PDB
72.33
25%
-119
- C4 -
3WBN
6
?
A:
[25-451]
--------------------------
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
-----------
A
D
G
I
W
V
S
G
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
PA
I
D
--
S
L
F
--------
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
-
T
L
G
F
---
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
W
L
F
-
V
K
R
D
T
-
Y
V
D
I
T
L
R
D
F
-
S
P
S
R
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
-
V
A
I
T
A
G
-
G
E
N
-
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
S
E
S
A
Q
---
V
I
K
G
D
L
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
--
M
M
T
S
A
-
M
F
Q
G
I
-
G
E
G
E
K
S
L
I
L
T
I
F
-----
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
-------
H
Y
-----
T
-----
T
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
-----
G
F
L
W
G
R
M
R
I
S
A
L
-----
3
PsiBlast_PDB
71.99
25%
-112
- C4 -
3VVO
10
?
A:
[25-451]
--------------------------
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
-----------
A
D
G
I
W
V
SG
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
PA
I
D
--
S
L
F
--------
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
-
T
L
G
F
---
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
W
L
F
-
V
K
R
D
T
-
Y
V
D
I
T
L
R
D
F
-
S
P
S
R
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
-
V
A
I
T
A
G
-
G
E
N
-
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
---------
I
K
G
D
L
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
--
M
M
T
S
A
-
M
F
Q
G
I
-
G
E
G
E
K
S
L
I
L
T
I
F
-----
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
-------
H
Y
-----
T
-----
T
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
-----
G
F
L
W
G
R
M
R
I
S
A
L
-----
6
PsiBlast_PDB
71.95
25%
-117
- C4 -
3VVS
13
?
A:
[25-451]
--------------------------
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
-----------
A
D
G
I
W
V
S
G
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
MLPA
I
D
--
S
L
F
--------
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
-
T
L
G
F
---
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
W
L
F
-
V
K
R
D
T
-
Y
V
D
I
T
L
R
D
F
-
S
P
S
R
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
-
V
A
I
T
A
G
-
G
E
N
-
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
----------
I
K
G
D
L
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
--
M
M
T
S
A
-
M
F
Q
G
I
-
G
E
G
E
K
S
L
I
L
T
I
F
-----
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
-------
H
Y
-----
T
-----
T
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
-----
G
F
L
W
G
R
M
R
I
S
A
L
-----
5
PsiBlast_PDB
71.82
25%
-110
- C4 -
3VVR
4
?
A:
[25-451]
--------------------------
I
P
M
M
I
G
M
S
V
Q
T
L
Y
N
L
-----------
A
D
G
I
W
V
S
G
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
PA
I
D
--
S
L
F
--------
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
-
T
L
G
F
---
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
W
L
F
-
V
K
R
D
T
-
Y
V
D
I
T
L
R
D
F
-
S
P
S
R
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
-
V
A
I
T
A
G
--
E
N
-
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
---------
I
K
G
D
L
I
S
A
L
R
T
L
P
V
F
L
V
LT
P
F
G
--
M
M
T
S
A
-
M
F
Q
G
I
-
G
E
G
E
K
S
L
I
L
T
I
F
-----
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
-------
H
--------------
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
-----
G
F
L
W
G
R
M
R
I
S
A
L
-----
24
HHSearch
71.20
22%
-153
- C4 -
3MKT
-
?
A:
[8-442]
--------------
Y
K
K
E
A
S
N
L
I
K
L
A
T
P
V
L
I
A
S
V
A
Q
T
G
M
G
F
V
D
T
-------
I
M
A
G
G
----
V
S
A
I
D
M
A
A
V
S
I
A
A
S
I
W
L
P
S
I
L
F
G
V
G
L
L
M
A
L
V
P
V
V
A
Q
L
N
G
A
G
R
Q
H
K
I
P
F
E
V
H
Q
G
L
I
L
A
L
L
V
S
V
P
I
I
A
-----
V
L
---
F
Q
-
T
Q
--
F
I
I
R
F
M
D
V
E
E
A
M
A
T
K
T
V
G
Y
M
H
A
V
I
F
A
V
P
A
Y
L
L
F
Q
A
L
R
S
F
T
D
G
M
S
L
T
K
P
A
M
V
I
G
F
I
G
L
L
L
N
I
P
L
N
W
I
F
V
Y
G
K
F
G
A
P
E
L
G
G
V
G
C
G
V
A
T
A
I
V
Y
W
I
M
L
L
L
L
L
F
Y
I
V
-
T
S
K
R
L
A
H
V
K
V
F
-
E
T
F
H
K
P
Q
P
K
E
L
I
R
L
F
R
L
G
F
P
V
A
A
A
L
F
F
E
V
T
L
F
A
V
V
A
L
-
L
-
V
A
P
L
-
G
S
T
-
V
-
V
A
A
H
Q
V
A
L
N
F
S
S
L
V
F
M
F
P
M
S
I
G
A
A
V
S
I
R
V
G
H
K
L
G
E
Q
D
T
K
G
A
A
I
A
A
N
V
G
L
M
T
G
L
A
T
A
C
I
T
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
T
E
N
Q
V
V
V
---
A
L
A
M
Q
L
L
--
L
F
A
A
I
Y
Q
C
M
---
D
A
V
Q
V
V
A
A
G
-
S
L
R
G
Y
-
K
D
M
T
A
I
F
H
R
T
F
I
-----
S
Y
W
V
L
G
L
P
T
G
Y
I
L
G
M
TNWLTE
Q
P
-----
L
-----
G
A
K
--
G
F
W
L
G
F
I
I
G
L
S
A
A
A
L
M
L
G
Q
-------------------
13
PsiBlast_PDB
70.03
24%
-144
- C4 -
3MKT
-
?
A:
[21-450]
---------------------------
P
V
L
I
A
S
V
A
Q
T
G
M
G
F
V
D
T
-------
I
M
A
G
G
V
---
S
A
I
D
-
M
A
A
V
S
I
A
A
S
I
W
L
P
S
I
L
F
G
V
G
L
L
M
A
L
V
P
V
V
A
Q
L
N
G
A
G
R
Q
H
K
I
P
F
E
V
H
Q
G
L
I
L
A
L
L
V
S
V
--
P
I
-----
I
A
--
V
L
F
Q
T
Q
--
F
I
I
R
F
M
D
V
E
E
A
M
A
T
K
T
V
G
Y
M
H
A
V
I
F
A
V
P
A
Y
L
L
F
Q
A
L
R
S
F
T
D
G
M
S
L
T
K
P
A
M
V
I
G
F
I
G
L
L
L
N
I
P
L
N
W
I
F
V
Y
G
K
F
G
A
P
E
L
G
G
V
G
C
G
V
A
T
A
I
V
Y
W
I
M
L
L
L
L
L
F
Y
I
V
-
T
S
K
R
-
L
A
H
V
K
V
F
E
T
F
H
K
P
Q
P
K
E
L
I
R
L
F
R
L
G
F
P
V
A
A
A
L
F
F
-
E
V
T
L
F
A
V
V
A
L
L
-
V
A
P
L
-
G
S
T
-
V
-
V
A
A
H
Q
V
A
L
N
F
S
S
L
V
F
M
F
P
M
S
I
G
A
A
V
S
I
R
V
G
H
K
L
G
E
Q
D
T
K
G
A
A
I
A
A
N
V
G
L
M
T
G
L
A
T
A
C
I
T
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
T
E
N
Q
V
V
V
---
A
L
A
M
Q
L
L
--
L
F
A
A
-
I
Y
Q
C
---
M
D
A
V
Q
V
V
A
A
G
S
L
R
G
------
Y
K
D
M
T
A
I
F
H
R
T
F
I
S
Y
W
V
L
G
L
P
T
G
Y
I
L
G
-------
M
T
-----
N
WLTEQ
P
L
G
A
K
G
F
W
L
G
F
I
I
G
L
S
A
A
A
L
M
L
--
G
Q
R
L
Y
W
L
Q
K
Q
---------
14
PsiBlast_PDB
69.85
24%
-143
- C4 -
3MKU
1
?
A:
[20-449]
---------------------------
P
V
L
I
A
S
V
A
Q
T
G
M
G
F
V
D
T
-------
I
M
A
G
G
V
---
S
A
I
D
-
M
A
A
V
S
I
A
A
S
I
W
L
P
S
I
L
F
G
V
G
L
L
M
A
L
V
P
V
V
A
Q
L
N
G
A
G
R
Q
H
K
I
P
F
E
V
H
Q
G
L
I
L
A
L
L
V
S
V
--
P
I
-----
I
A
--
V
L
F
Q
T
Q
--
F
I
I
R
F
M
D
V
E
E
A
M
A
T
K
T
V
G
Y
M
H
A
V
I
F
A
V
P
A
Y
L
L
F
Q
A
L
R
S
F
T
D
G
M
S
L
T
K
P
A
M
V
I
G
F
I
G
L
L
L
N
I
P
L
N
W
I
F
V
Y
G
K
F
G
A
P
E
L
G
G
V
G
C
G
V
A
T
A
I
V
Y
W
I
M
L
L
L
L
L
F
Y
I
V
-
T
S
K
R
-
L
A
H
V
K
V
F
E
T
F
H
K
P
Q
P
K
E
L
I
R
L
F
R
L
G
F
P
V
A
A
A
L
F
F
-
E
V
T
L
F
A
V
V
A
L
L
-
V
A
P
L
-
G
S
T
-
V
-
V
A
A
H
Q
V
A
L
N
F
S
S
L
V
F
M
F
P
M
S
I
G
A
A
V
S
I
R
V
G
H
K
L
G
E
Q
D
T
K
G
A
A
I
A
A
N
V
G
L
M
T
G
L
A
T
A
C
I
T
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
T
E
N
Q
V
V
V
---
A
L
A
M
Q
L
L
--
L
F
A
A
-
I
Y
Q
C
---
M
D
A
V
Q
V
V
A
A
G
S
L
R
G
------
Y
K
D
M
T
A
I
F
H
R
T
F
I
S
Y
W
V
L
G
L
P
T
G
Y
I
L
G
-------
M
T
-----
N
WLTEQ
P
L
G
A
K
G
F
W
L
G
F
I
I
G
L
S
A
A
A
L
M
L
--
G
Q
R
L
Y
W
L
Q
K
Q
---------
8
PsiBlast_PDB
69.72
25%
-107
- C4 -
3W4T
9
?
A:
[24-451]
------------------------------------
S
I
A
M
M
I
G
M
S
V
Q
T
L
Y
N
L
A
D
G
I
W
V
S
G
L
G
P
E
S
L
A
A
V
G
L
F
F
P
V
F
M
G
I
I
A
L
A
A
G
L
G
V
G
T
S
S
A
I
A
R
R
I
G
A
R
D
K
E
G
A
D
N
V
A
V
H
S
L
I
L
S
L
I
L
G
V
T
I
T
I
T
M
L
PA
I
D
--
S
L
F
--------
R
S
M
G
A
K
G
E
A
V
E
L
A
I
E
Y
A
R
V
L
L
A
G
A
F
I
I
V
F
N
N
V
G
N
G
I
L
R
G
E
G
D
A
N
R
A
M
L
A
M
V
L
G
S
G
L
N
I
V
L
D
P
I
F
I
Y
-
T
L
G
F
---
G
V
V
G
A
A
Y
A
T
L
L
S
M
V
V
T
S
L
F
I
A
Y
W
L
F
-
V
K
R
D
T
-
Y
V
D
I
T
L
R
D
F
-
S
P
S
R
E
I
L
K
D
I
L
R
V
G
L
P
S
S
L
S
Q
L
S
M
S
I
A
M
F
F
L
N
S
-
V
A
I
T
A
G
-
G
E
N
-
G
-
V
A
V
F
T
S
A
W
R
I
T
M
L
G
I
V
P
I
L
G
M
A
A
A
T
T
S
V
T
G
A
A
Y
G
E
R
N
V
E
K
L
E
T
A
Y
L
Y
A
I
K
I
A
F
M
I
E
L
A
V
V
A
F
I
M
L
F
A
P
Q
V
A
Y
L
F
T
Y
--------
V
I
K
G
D
L
I
S
A
L
R
T
L
P
V
F
L
V
L
T
P
F
G
--
M
M
T
S
A
-
M
F
Q
G
I
-
G
E
G
E
K
S
L
I
L
T
I
F
-----
R
T
L
V
M
Q
V
G
F
A
Y
I
F
V
-------
H
Y
-----
T
-----
T
L
G
L
R
G
V
W
I
G
I
V
I
G
N
M
V
A
A
I
V
-----
G
F
L
W
G
R
M
R
I
S
A
L
-----
23
HHSearch
68.19
21%
-159
* C4 *
5C6N
-
?
A:
[12-436]
--------------
T
E
A
I
P
K
L
L
R
S
L
S
I
P
A
M
I
G
M
F
V
M
A
L
Y
N
V
V
N
T
-------
I
F
I
S
Y
A
---
V
G
I
E
G
V
A
G
V
T
I
A
F
P
I
M
M
I
M
M
S
M
A
G
A
L
G
I
G
G
A
S
V
I
S
R
R
L
G
E
R
R
G
E
E
A
N
Q
V
F
G
N
I
L
T
V
I
L
V
L
S
V
I
G
F
I
-----
S
A
--
F
T
L
-
L
G
--
P
A
L
Q
L
F
G
A
T
S
V
T
Q
G
Y
A
T
D
Y
L
F
P
I
L
L
G
S
I
F
F
F
F
A
F
A
A
N
N
I
I
R
S
E
G
N
A
T
F
A
M
V
T
M
I
V
P
A
V
L
N
I
L
L
D
V
L
F
I
F
G
----
L
N
M
G
V
L
G
A
S
I
A
T
V
I
A
Q
A
S
V
T
G
L
V
L
R
Y
F
L
-
T
G
K
S
T
L
S
L
H
W
---
S
D
L
R
M
K
G
S
V
I
K
E
V
C
L
V
G
L
P
A
F
V
Q
Q
S
S
A
S
L
M
M
I
A
I
N
S
-
M
-
L
L
R
F
G
S
D
F
-
Y
-
V
G
V
F
G
L
V
Q
R
I
M
M
F
V
M
M
P
M
M
G
I
M
Q
A
M
Q
P
I
V
G
Y
N
Y
G
A
K
Q
Y
S
R
L
R
E
T
V
M
L
G
F
K
V
A
T
I
F
S
I
G
I
F
A
L
L
M
L
F
P
E
A
L
L
R
V
F
T
A
D
R
E
V
I
---
Q
A
G
V
S
A
M
--
H
I
L
F
C
V
T
F
L
---
I
G
A
Q
I
V
A
G
G
-
L
Y
Q
S
L
-
G
K
P
K
Q
A
L
I
L
S
L
S
-----
R
Q
I
I
F
L
I
P
L
V
L
I
L
P
-------
H
I
-----
F
-----
G
L
S
--
G
V
W
W
A
F
P
I
A
D
V
L
S
F
I
L
T
V
V
-------------------
11
PsiBlast_PDB
67.43
24%
-132
- C4 -
4LZ6
-
?
A:
[13-433]
------------
E
A
I
P
K
L
L
R
S
L
S
---
I
P
A
M
I
G
M
F
V
M
A
L
Y
N
V
V
D
T
-------
I
F
I
S
Y
A
---
V
G
I
E
G
V
A
G
V
T
I
A
F
P
I
M
M
I
M
M
S
M
A
G
A
L
G
I
G
G
A
S
V
I
S
R
R
L
G
E
R
R
G
E
E
A
N
Q
V
F
G
N
I
L
T
V
I
----
L
V
L
S
V
-----
I
G
F
I
S
A
F
-
T
L
L
G
P
A
L
Q
L
F
G
A
T
S
V
T
Q
G
Y
A
T
D
Y
L
F
P
I
L
L
G
S
I
F
F
F
F
A
F
A
A
N
N
I
I
R
S
E
G
N
A
T
F
A
M
V
T
M
I
V
P
A
V
L
N
I
L
L
D
V
L
F
I
F
G
L
----
N
M
G
V
L
G
A
S
I
A
T
V
I
A
Q
A
S
V
T
G
L
V
L
R
Y
F
L
-
T
G
K
S
T
L
S
L
H
W
S
---
D
L
R
M
K
G
S
V
I
K
E
V
C
L
V
G
L
P
A
F
V
Q
Q
S
S
A
S
L
M
M
I
A
I
N
S
-
M
-
L
L
R
F
-
G
S
D
F
Y
-
V
G
V
F
G
L
V
Q
R
I
M
M
F
V
M
M
P
M
M
G
I
M
Q
A
M
Q
P
I
V
G
Y
N
Y
G
A
K
Q
Y
S
R
L
R
E
T
V
M
L
G
F
K
V
A
T
I
F
S
I
G
I
F
A
L
L
M
L
F
P
E
A
L
L
R
V
F
T
A
D
R
E
V
I
---
Q
A
G
V
S
A
M
--
H
I
L
F
C
V
T
F
L
---
I
G
-
A
Q
I
V
A
G
-
G
L
Y
Q
S
L
G
K
P
K
Q
A
L
I
L
S
L
S
-----
R
Q
I
I
F
L
I
P
L
V
L
I
L
P
-------
H
I
-----
F
-----
G
L
S
--
G
V
W
W
A
F
P
I
A
D
V
L
S
F
I
L
----------------------
32
Fugue
65.97
22%
-138
- C4 -
4LZ6
-
?
A:
[3-448]
Q
K
Q
Q
S
E
R
L
G
T
E
--
A
I
P
K
L
L
R
S
L
S
---
I
P
A
M
I
G
M
F
V
M
A
L
Y
N
V
V
D
T
-------
I
F
I
S
Y
A
---
V
G
I
E
G
V
A
G
V
T
I
A
F
P
I
M
M
I
M
M
S
M
A
G
A
L
G
I
G
G
A
S
V
I
S
R
R
L
G
E
R
R
G
E
E
A
N
Q
V
F
G
N
I
L
T
V
I
L
V
L
S
V
I
G
F
I
-----
S
A
--
F
T
L
-
L
G
--
P
A
L
Q
L
F
G
A
T
S
V
T
Q
G
Y
A
T
D
Y
L
F
P
I
L
L
G
S
I
F
F
F
F
A
F
A
A
N
N
I
I
R
S
E
G
N
A
T
F
A
M
V
T
M
I
V
P
A
V
L
N
I
L
L
D
V
L
F
I
F
G
L
----
N
M
G
V
L
G
A
S
I
A
T
V
I
A
Q
A
S
V
T
G
L
V
L
R
Y
F
L
-
T
G
K
S
T
L
S
L
H
W
S
---
D
L
R
M
K
G
S
V
I
K
E
V
C
L
V
G
L
P
A
F
V
Q
Q
S
S
A
S
L
M
M
I
A
I
N
S
-
M
-
L
L
R
F
-
G
S
D
-
F
Y
V
G
V
F
G
L
V
Q
R
I
M
M
F
V
M
M
P
M
M
G
I
M
Q
A
M
Q
P
I
V
G
Y
N
Y
G
A
K
Q
Y
S
R
L
R
E
T
V
M
L
G
F
K
V
A
T
I
F
S
I
G
I
F
A
L
L
M
L
F
P
E
A
L
L
R
V
F
T
A
D
R
E
V
I
---
Q
A
G
V
S
A
M
--
H
I
L
F
C
V
T
F
L
---
I
G
A
Q
I
V
A
G
G
-
L
Y
Q
S
L
-
G
K
P
K
Q
A
L
I
L
S
L
S
-----
R
Q
I
I
F
L
I
P
L
V
L
I
L
P
-------
H
I
-----
F
-----
G
L
--
S
G
V
W
W
A
F
P
I
A
D
V
L
S
F
I
L
T
V
V
L
L
Y
----
R
D
R
N
V
F
F
L
K
---
21
HHSearch
65.40
17%
-197
- C4 -
4Z3N
7
?
A:
[24-450]
-------------
F
D
G
S
L
Y
K
L
L
L
R
M
A
L
P
M
F
V
G
M
L
T
Q
V
T
Y
A
I
A
D
I
-------
F
W
L
S
H
-------
G
I
I
A
G
V
G
L
V
F
P
V
G
M
G
L
F
A
I
A
N
G
I
Q
I
G
M
G
S
L
L
S
R
A
I
G
M
Q
R
L
D
R
A
Q
R
I
L
S
V
G
I
I
I
A
L
F
F
A
I
V
I
T
V
-----
L
G
--
Y
V
Y
-
A
Q
--
P
L
L
R
S
L
G
A
T
K
S
I
I
G
Y
A
T
E
F
Y
Y
Y
S
L
L
T
V
F
S
I
M
L
I
G
V
M
M
G
L
F
Q
G
A
G
K
I
M
V
I
M
K
A
S
L
L
G
A
L
V
N
I
M
L
D
P
I
M
I
F
V
----
F
D
F
G
V
K
G
V
A
L
A
S
F
L
A
Q
L
S
M
V
A
Y
F
I
Y
T
L
M
-
G
-----------------
S
W
K
I
Y
R
E
F
L
S
V
G
M
A
Q
M
L
M
Q
L
I
I
A
V
G
I
V
I
Y
N
F
-
F
-
I
V
R
L
-
D
V
N
-
A
-
M
A
A
F
T
L
T
G
R
I
D
Y
F
I
I
T
P
M
L
A
I
A
T
A
L
L
T
V
V
G
Q
N
W
G
H
G
N
V
T
R
T
L
N
A
Y
W
A
A
V
A
L
A
F
S
I
V
L
V
L
A
V
M
H
I
V
L
A
P
W
M
Y
P
L
F
T
R
V
V
A
V
S
---
D
Y
A
V
L
Q
T
--
R
I
M
A
L
A
L
P
F
---
V
A
I
S
L
L
A
S
E
-
Y
Y
Q
A
I
-
G
K
P
W
Y
S
V
L
L
T
L
M
-----
R
H
V
F
I
S
V
P
V
V
Y
L
L
A
-------
I
V
-----
L
-----
E
M
R
I
T
G
V
Y
F
G
A
M
S
G
T
F
V
A
A
L
L
A
---------------------
9
PsiBlast_PDB
65.31
24%
-118
- C4 -
5C6N
-
?
A:
[3-433]
--
Q
K
Q
Q
S
E
R
L
G
T
E
A
I
P
K
L
L
R
S
L
S
---
I
P
A
M
I
G
M
F
V
M
A
L
Y
N
V
V
N
T
-------
I
F
I
S
Y
A
---
V
G
I
E
G
V
A
G
V
T
I
A
F
P
I
M
M
I
M
M
S
M
A
G
A
L
G
I
G
G
A
S
V
I
S
R
R
L
G
E
R
R
G
E
E
A
N
Q
V
F
G
N
I
L
T
V
I
----
L
V
L
S
V
-----
I
G
F
I
S
A
F
-
T
L
L
G
P
A
L
Q
L
F
G
A
T
S
V
T
Q
G
Y
A
T
D
Y
L
F
P
I
L
L
G
S
I
F
F
F
F
A
F
A
A
N
N
I
I
R
S
E
G
N
A
T
F
A
M
V
T
M
I
V
P
A
V
L
N
I
L
L
D
V
L
F
I
F
G
L
----
N
M
G
V
L
G
A
S
I
A
T
V
I
A
Q
A
S
V
T
G
L
V
L
R
Y
F
L
-
T
G
K
S
T
L
S
L
H
W
S
---
D
L
R
M
K
G
S
V
I
K
E
V
C
L
V
G
L
P
A
F
V
Q
Q
S
S
A
S
L
M
M
I
A
I
N
S
-
M
-
L
L
R
F
-
G
S
D
F
Y
-
V
G
V
F
G
L
V
Q
R
I
M
M
F
V
M
M
P
M
M
G
I
M
Q
A
M
Q
P
I
V
G
Y
N
Y
G
A
K
Q
Y
S
R
L
R
E
T
V
M
L
G
F
K
V
A
T
I
F
S
I
G
I
F
A
L
L
M
L
F
P
E
A
L
L
R
V
F
T
A
D
R
E
V
I
---
Q
A
G
V
S
A
M
--
H
I
L
F
C
V
T
F
L
---
I
G
-
A
Q
I
V
A
G
-
G
L
Y
Q
S
L
G
K
P
K
Q
A
L
I
L
S
L
S
-----
R
Q
I
I
F
L
I
P
L
V
L
I
L
P
-------
H
I
-----
F
-----
G
L
S
--
G
V
W
W
A
F
P
I
A
D
V
L
S
F
I
L
----------------------
10
PsiBlast_PDB
64.79
24%
-120
- C4 -
5C6O
1
?
A:
[3-433]
--
Q
K
Q
Q
S
E
R
L
G
T
E
A
I
P
K
L
L
R
S
L
S
---
I
P
A
M
I
G
M
F
V
M
A
L
Y
N
V
V
D
T
-------
I
F
I
S
Y
A
---
V
G
I
E
G
V
A
G
V
T
I
A
F
P
I
M
M
I
M
M
S
M
A
G
A
L
G
I
G
G
A
S
V
I
S
R
R
L
G
E
R
R
G
E
E
A
N
Q
V
F
G
N
I
L
T
V
I
----
L
V
L
S
V
-----
I
G
F
I
S
A
F
-
T
L
LG
P
A
L
Q
L
F
G
A
T
S
V
T
Q
G
Y
A
T
D
Y
L
F
P
I
L
L
G
S
I
F
F
F
F
A
F
A
A
N
N
I
I
R
S
E
G
N
A
T
F
A
M
V
T
M
I
V
P
A
V
L
N
I
L
L
D
V
L
F
I
F
G
L
----
N
M
G
V
L
G
A
S
I
A
T
V
I
A
Q
A
S
V
T
G
L
V
L
R
Y
F
L
-
T
G
K
S
T
L
S
L
H
W
S
---
D
L
R
M
K
G
S
V
I
K
E
V
C
L
V
G
L
P
A
F
V
Q
Q
S
S
A
S
L
M
M
I
A
I
N
S
-
M
-
L
L
R
F
-
G
S
D
F
Y
-
V
G
V
F
G
L
V
Q
R
I
M
M
F
V
M
M
P
M
M
G
I
M
Q
A
M
Q
P
I
V
G
Y
N
Y
G
A
K
Q
Y
S
R
L
R
E
T
V
M
L
G
F
K
V
A
T
I
F
S
I
G
I
F
A
L
L
M
L
F
P
E
A
L
L
R
V
F
T
A
D
R
E
V
I
---
Q
A
G
V
S
A
M
--
H
I
L
F
C
V
T
F
L
---
I
G
-
A
Q
I
V
A
G
-
G
L
Y
Q
S
L
G
K
P
K
Q
A
L
I
L
S
L
S
-----
R
Q
I
I
F
L
I
P
L
V
L
I
L
P
-------
H
I
-----
F
-----
G
L
S
--
G
V
W
W
A
F
P
I
A
D
V
L
S
F
I
L
----------------------