@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22640: (2016-07-05 )
MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFREEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAKKMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVVPVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQLKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKGTVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEAVDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVLEEEVKAHV
Atome Classification :
(85 SA)
.........10........20........30........40........50........60........70..-..--....80........90........100......-.110.......120.......130.......140.......150.......160...---------------....170.......180---.......190.......200.......210.......220.......230.......240...--..--.-.250........260....--...270.......280...-----------....290.......300.......310.......320..-.....330.......340.......350....---...360...-..-.-.370.......380.......----390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MYPYPNEIGRYGDFGGKFV
P
E
T
L
M
Q
P
L
D
E
I
Q
T
A
F
K
QIKDD
P
A
F
R
E
E
Y
Y
K
L
L
K
DYSGRP
T
A
L
T
Y
A
D
R
V
T
E
Y
LGG-
A
K
--
I
Y
L
K
REDLNHTGS
H
K
I
N
N
A
L
G
Q
A
L
L
A
K
KMGK
T
K
-
I
I
A
ETGAGQHG
V
A
A
A
T
V
A
A
KFG
F
S
C
T
V
F
MG
E
E
D
V
A
R
Q
S
L
N
V
F
R
M
K
LLG
A
E
V
V
P
VTSG---------------NGTLKDA
T
N
E
A
I
R
Y
W
V
Q
---
H
CEDH
F
Y
M
I
GSVVGPHP
Y
P
Q
V
V
R
E
F
Q
K
M
I
G
E
E
A
K
D
Q
L
K
R
I
EGTMP
D
K
V
V
A
C
VGGGS
N
A
M
G
M
F
Q
--
A
F
--
L
-NE-
D
V
E
LIGAEAAGKGIDT--PL
H
A
A
TISKG
T
V
G
V
I
HG
S
L
-----------
T
Y
L
I
Q
D
E
F
G
Q
I
IEPYSISAGLDYPGIGP
E
H
A
Y
L
HKSG
R
V
-
T
YDSIT
D
E
E
A
V
D
A
L
K
L
L
S
EKEGI
L
P
A
I
E
S
A
H
A
---
L
A
K
A
F
K
L
A
K-GM-D-RG
Q
L
I
L
V
C
LSGRGDK
D
V
N
T
L
M
----
N
V
L
E
E
E
V
K
AHV-
37
PsiBlast_CBE
90.04
59%
-45
- C3 -
5DW3
2
TRPB1_PYRFU
C:
[3-385]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
E
-
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
KVS-------------
3
PsiBlast_PDB
88.47
59%
-43
- C3 -
5DW0
2
TRPB1_PYRFU
A:
[3-388]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
K
V
SG
N
V
----------
23
PsiBlast_CBE
88.44
59%
-42
- C3 -
5DW0
2
TRPB1_PYRFU
D:
[3-385]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
KVS-------------
7
PsiBlast_PDB
88.42
59%
-43
- C3 -
5DVZ
2
TRPB1_PYRFU
A:
[3-384]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
KV--------------
39
PsiBlast_CBE
88.37
59%
-43
- C3 -
5DVZ
2
TRPB1_PYRFU
D:
[3-385]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
KVS-------------
36
PsiBlast_CBE
88.26
59%
-45
- C3 -
5DW3
2
TRPB1_PYRFU
D:
[3-385]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
E
-
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
KVS-------------
41
PsiBlast_CBE
88.11
59%
-47
- C3 -
5DVZ
2
TRPB1_PYRFU
B:
[3-384]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
--
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
KV--------------
40
PsiBlast_CBE
87.93
59%
-43
- C3 -
5DVZ
2
TRPB1_PYRFU
C:
[3-386]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
--
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
KVSG------------
24
PsiBlast_CBE
87.87
59%
-44
- C3 -
5DW0
2
TRPB1_PYRFU
C:
[3-385]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
KVS-------------
8
PsiBlast_PDB
87.81
56%
-48
- C3 -
1X1Q
1
TRPB_THET2
A:
[21-416]
-
F
P
L
P
D
A
R
G
R
F
G
P
Y
G
G
R
Y
V
P
E
T
L
I
P
A
L
E
E
L
E
A
A
Y
R
E
A
K
K
D
P
A
F
L
E
E
L
D
H
Y
L
R
Q
F
A
G
R
P
T
P
L
Y
H
A
K
R
L
S
E
Y
W
G
G
-
A
Q
--
V
F
L
K
R
E
D
L
L
H
T
G
A
H
K
I
N
N
T
L
G
Q
A
L
L
A
R
R
M
G
K
R
R
-
V
I
A
E
T
G
A
G
Q
H
G
V
S
V
A
T
V
A
A
L
F
G
L
E
C
V
V
Y
M
G
E
E
D
V
R
R
Q
A
L
N
V
F
R
M
K
L
L
G
A
E
V
R
P
V
A
A
G
---------------
S
R
T
L
K
D
A
T
N
E
A
I
R
D
W
I
T
---
N
V
R
T
T
F
Y
I
L
G
S
V
V
G
P
H
P
Y
P
M
M
V
R
D
F
Q
S
V
I
G
E
E
V
K
R
Q
S
L
E
L
F
G
R
L
P
D
A
L
I
A
A
V
G
G
G
S
N
A
I
G
L
F
A
PF
A
Y
--
L
-
P
E
G
R
P
K
L
I
G
V
E
A
A
G
E
G
L
S
T
--
G
R
H
A
A
S
I
G
A
G
K
R
G
V
L
H
G
S
Y
-----------
M
Y
L
L
Y
D
----------------
Y
P
G
V
G
P
E
H
S
Y
Y
A
D
A
G
V
A
-
E
Y
A
S
V
T
D
E
E
A
L
E
G
F
K
L
L
A
R
L
E
G
I
I
P
A
L
E
S
A
H
A
---
I
A
Y
A
A
K
V
V
P
-
E
M
-
D
-
K
D
Q
V
V
V
I
N
L
S
G
R
G
D
K
D
V
T
E
V
M
----
R
L
L
G
G
-------
38
PsiBlast_CBE
87.72
59%
-41
- C3 -
5DW3
2
TRPB1_PYRFU
B:
[3-387]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
E
-
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
KVSG
N
-----------
29
PsiBlast_CBE
87.66
59%
-45
- C3 -
1WDW
1
TRPB1_PYRFU
F:
[3-384]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
----
K
V
----------
30
PsiBlast_CBE
87.63
59%
-44
- C3 -
1WDW
1
TRPB1_PYRFU
D:
[3-384]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
----
K
V
----------
21
PsiBlast_CBE
87.55
59%
-42
- C3 -
1V8Z
2
TRPB1_PYRFU
C:
[3-384]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
----
K
V
----------
4
PsiBlast_PDB
87.54
59%
-43
- C3 -
1WDW
1
TRPB1_PYRFU
B:
[3-384]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
----
K
V
----------
27
PsiBlast_CBE
87.53
59%
-45
- C3 -
1WDW
1
TRPB1_PYRFU
J:
[3-384]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
----
K
V
----------
2
PsiBlast_PDB
87.43
59%
-42
- C3 -
1V8Z
2
TRPB1_PYRFU
A:
[3-384]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
----
K
V
----------
35
PsiBlast_CBE
87.38
59%
-45
- C3 -
5E0K
1
TRPB1_PYRFU
D:
[3-385]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
KVS-------------
26
PsiBlast_CBE
87.37
59%
-44
- C3 -
1WDW
1
TRPB1_PYRFU
L:
[3-384]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
----
K
V
----------
25
PsiBlast_CBE
87.32
59%
-43
- C3 -
5DW0
2
TRPB1_PYRFU
B:
[3-385]
----------
F
G
E
F
G
G
Q
Y
V
P
E
T
L
I
E
P
L
K
E
L
E
K
A
Y
K
R
F
K
D
D
E
E
F
N
R
Q
L
N
Y
Y
L
K
T
W
A
G
R
P
T
P
L
Y
Y
A
K
R
L
T
E
K
I
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
V
H
G
G
A
H
K
T
N
N
A
I
G
Q
A
L
L
A
K
F
M
G
K
T
R
-
L
I
A
E
T
G
A
G
Q
H
G
V
A
T
A
M
A
G
A
L
L
G
M
K
V
D
I
Y
M
G
A
E
D
V
E
R
Q
K
M
N
V
F
R
M
K
L
L
G
A
N
V
I
P
V
N
S
G
---------------
S
R
T
L
K
D
A
I
N
E
A
L
R
D
W
V
A
---
T
F
E
Y
T
H
Y
L
I
G
S
V
V
G
P
H
P
Y
P
T
I
V
R
D
F
Q
S
V
I
G
R
E
A
K
A
Q
I
L
E
A
E
G
Q
L
P
D
V
I
V
A
C
V
G
G
G
S
N
A
M
G
I
F
Y
--
P
F
--
V
-
N
D
K
K
V
K
L
V
G
V
E
A
G
G
K
G
L
E
S
--
G
K
H
S
A
S
L
N
A
G
Q
V
G
V
F
H
G
M
L
-----------
S
Y
F
L
Q
D
E
E
G
Q
I
K
P
T
H
S
I
A
P
G
L
D
Y
P
G
V
G
P
E
H
A
Y
L
K
K
I
Q
R
A
-
E
Y
V
T
V
T
D
E
E
A
L
K
A
F
H
E
L
S
R
T
E
G
I
I
P
A
L
E
S
A
H
A
---
V
A
Y
A
M
K
L
A
K
-
E
M
-
S
-
R
D
E
I
I
I
V
N
L
S
G
R
G
D
K
D
L
D
I
V
L
KVS-------------
11
PsiBlast_PDB
87.18
55%
-40
- C3 -
2DH5
4
TRPB_ECOLI
A:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
R
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
N
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
N
--
T
T
--
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
T
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
E
R
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
E
T
N
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
E
--
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
T
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
L
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
E
N
P
-
D
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
19
PsiBlast_PDB
82.67
54%
-1
- C3 -
2CLF
4
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
56
PsiBlast_CBE
82.64
54%
1
- C3 -
2CLL
3
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
66
PsiBlast_CBE
82.48
54%
-1
- C3 -
5BW6
3
?
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
73
PsiBlast_CBE
82.33
54%
1
- C3 -
4HPX
13
TRPB_SALTY
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
79
PsiBlast_CBE
82.30
54%
1
- C3 -
1KFC
2
TRPB_SALTY
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
78
PsiBlast_CBE
82.19
54%
-1
- C3 -
1KFJ
2
TRPB_SALTY
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
16
PsiBlast_PDB
82.15
54%
-2
- C3 -
2CLH
2
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
53
PsiBlast_CBE
82.12
54%
1
- C3 -
1KFE
2
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
76
PsiBlast_CBE
82.06
54%
2
- C3 -
2RH9
2
TRPB_SALTY
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
75
PsiBlast_CBE
81.99
54%
2
- C3 -
4HN4
9
TRPB_SALTY
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
71
PsiBlast_CBE
81.99
54%
-1
- C3 -
4KKX
15
TRPB_SALTY
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
91
PsiBlast_CBE
81.98
54%
-6
- C3 -
1QOQ
1
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
A
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
103
HHSearch
81.91
61%
-61
- C3 -
4NEG
5
TRPB_BACAN
A:
[23-397]
------------------
V
P
E
T
L
M
Q
S
V
L
E
L
E
E
A
Y
K
E
A
M
E
D
E
A
F
Q
K
E
L
N
H
Y
L
K
T
Y
V
G
R
E
T
P
L
Y
F
A
E
N
M
T
E
Y
C
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
N
H
T
G
A
H
K
I
N
N
T
I
G
Q
A
L
L
A
V
R
M
G
K
K
K
-
V
V
A
E
T
G
A
G
Q
H
G
V
A
T
A
T
V
C
A
L
L
G
L
E
C
V
I
F
M
G
E
E
D
V
R
R
Q
K
L
N
V
F
R
M
E
L
L
G
A
K
V
E
S
V
A
A
G
-----------------
T
L
K
D
A
V
N
E
A
L
R
Y
W
V
S
---
H
V
H
D
T
H
Y
I
M
G
S
V
L
G
P
H
P
F
P
Q
I
V
R
D
F
Q
S
V
I
G
N
E
T
K
K
Q
Y
E
A
L
E
G
K
L
P
E
A
V
V
A
C
I
G
G
G
S
N
A
M
G
M
F
Y
--
P
F
--
V
-
H
D
E
E
V
A
L
Y
G
V
E
A
A
G
----------------------------------------------------------
D
Y
------
H
S
L
L
K
D
I
G
R
V
-
S
Y
H
S
I
T
D
D
E
A
L
E
A
F
Q
L
L
T
K
K
E
G
I
I
P
A
L
E
S
S
H
A
---
V
A
Y
A
L
K
L
A
P
-
Q
M
-
K
-
E
D
E
G
L
V
I
C
L
S
G
R
G
D
K
D
V
E
S
I
K
----
R
Y
M
---------
92
PsiBlast_CBE
81.88
54%
-6
- C3 -
2J9Z
2
TRPB_SALTY
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
V
G
A
G
N
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
1
PsiBlast_PDB
81.83
59%
-61
- C3 -
4NEG
5
TRPB_BACAN
A:
[23-397]
------------------
V
P
E
T
L
M
Q
S
V
L
E
L
E
E
A
Y
K
E
A
M
E
D
E
A
F
Q
K
E
L
N
H
Y
L
K
T
Y
V
G
R
E
T
P
L
Y
F
A
E
N
M
T
E
Y
C
G
G
-
A
K
--
I
Y
L
K
R
E
D
L
N
H
T
G
A
H
K
I
N
N
T
I
G
Q
A
L
L
A
V
R
M
G
K
K
K
-
V
V
A
E
T
G
A
G
Q
H
G
V
A
T
A
T
V
C
A
L
L
G
L
E
C
V
I
F
M
G
E
E
D
V
R
R
Q
K
L
N
V
F
R
M
E
L
L
G
A
K
V
E
S
V
A
A
G
-----------------
T
L
K
D
A
V
N
E
A
L
R
Y
W
V
S
---
H
V
H
D
T
H
Y
I
M
G
S
V
L
G
P
H
P
F
P
Q
I
V
R
D
F
Q
S
V
I
G
N
E
T
K
K
Q
Y
E
A
L
E
G
K
L
P
E
A
V
V
A
C
I
G
G
G
S
N
A
M
G
M
F
Y
--
P
F
--
V
H
D
E
-
E
V
A
L
Y
G
V
E
A
A
G
----------------------------------------------------------
D
Y
------
H
S
L
L
K
D
I
G
R
V
-
S
Y
H
S
I
T
D
D
E
A
L
E
A
F
Q
L
L
T
K
K
E
G
I
I
P
A
L
E
S
S
H
A
---
V
A
Y
A
L
K
L
A
P
-
Q
M
-
K
-
E
D
E
G
L
V
I
C
L
S
G
R
G
D
K
D
V
E
S
I
K
----
R
Y
M
---------
82
PsiBlast_CBE
81.73
54%
-2
- C3 -
1K8Y
2
TRPB_SALTY
B:
[8-390]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
P
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
---------
74
PsiBlast_CBE
81.70
54%
0
- C3 -
4HPJ
11
TRPB_SALTY
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
50
PsiBlast_CBE
81.70
54%
-2
- C3 -
1BEU
2
TRPB_SALTY
B:
[9-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
---------
58
PsiBlast_CBE
81.63
54%
-3
- C3 -
2CLI
3
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
55
PsiBlast_CBE
81.58
54%
-1
- C3 -
2J9X
7
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
54
PsiBlast_CBE
81.57
54%
0
- C3 -
3CEP
4
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
15
PsiBlast_PDB
81.50
54%
-0
- C3 -
2CLE
3
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
68
PsiBlast_CBE
81.49
54%
2
- C3 -
4Y6G
4
?
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
90
PsiBlast_CBE
81.48
54%
0
- C3 -
1FUY
2
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
L
W
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
62
PsiBlast_CBE
81.47
54%
-3
- C3 -
1KFB
1
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
80
PsiBlast_CBE
81.40
54%
-1
- C3 -
1K8X
2
TRPB_SALTY
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
89
PsiBlast_CBE
81.39
54%
0
- C3 -
2J9Y
2
TRPB_SALTY
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
N
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
61
PsiBlast_CBE
81.34
54%
1
- C3 -
1QOP
2
TRPB_SALTY
B:
[8-390]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
---------
72
PsiBlast_CBE
81.30
54%
-2
- C3 -
4HT3
20
TRPB_SALTY
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
51
PsiBlast_CBE
81.17
54%
-1
- C3 -
1A5B
2
TRPB_SALTY
B:
[9-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
---------
52
PsiBlast_CBE
81.12
54%
-1
- C3 -
1A5A
2
TRPB_SALTY
B:
[9-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
---------
59
PsiBlast_CBE
81.09
54%
0
- C3 -
1WBJ
2
TRPB_SALTY
B:
[8-390]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
---------
57
PsiBlast_CBE
81.09
54%
0
- C3 -
2CLK
2
TRPB_SALTY
B:
[8-390]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
---------
60
PsiBlast_CBE
80.99
54%
2
- C3 -
1TJP
2
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
45
PsiBlast_CBE
80.88
54%
3
- C3 -
1C9D
2
TRPB_SALTY
B:
[9-389]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
-----------
85
PsiBlast_CBE
80.86
54%
-0
- C3 -
2TYS
2
TRPB_SALTY
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
65
PsiBlast_CBE
80.85
54%
1
- C3 -
1K3U
2
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
18
PsiBlast_PDB
80.81
54%
1
- C3 -
2CLO
2
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
44
PsiBlast_CBE
80.77
54%
4
- C3 -
1CW2
2
TRPB_SALTY
B:
[9-389]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
-----------
67
PsiBlast_CBE
80.73
54%
1
- C3 -
4ZQC
13
?
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
70
PsiBlast_CBE
80.72
54%
2
- C3 -
4WX2
6
TRPB_SALTY
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
84
PsiBlast_CBE
80.65
54%
1
- C3 -
3PR2
5
TRPB_SALTY
B:
[7-390]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
64
PsiBlast_CBE
80.63
54%
1
- C3 -
1K7E
2
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
46
PsiBlast_CBE
80.54
54%
5
- C3 -
1C8V
2
TRPB_SALTY
B:
[9-389]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
-----------
83
PsiBlast_CBE
80.52
54%
0
- C3 -
1K7X
2
TRPB_SALTY
B:
[8-390]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
P
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
---------
69
PsiBlast_CBE
80.48
54%
-0
- C3 -
4XUG
4
TRPB_SALTY
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
77
PsiBlast_CBE
80.35
54%
2
- C3 -
1KFK
2
TRPB_SALTY
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
48
PsiBlast_CBE
80.28
54%
-2
- C3 -
1BKS
2
TRPB_SALTY
B:
[9-392]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
13
PsiBlast_PDB
80.05
54%
2
- C3 -
1A50
2
TRPB_SALTY
B:
[8-390]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
---------
49
PsiBlast_CBE
79.96
54%
2
- C3 -
1A5S
3
TRPB_SALTY
B:
[9-389]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
-----------
88
PsiBlast_CBE
79.93
54%
-0
* C3 *
1UBS
3
TRPB_SALTY
B:
[9-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
---------
20
PsiBlast_PDB
79.84
54%
-1
- C3 -
1TTP
3
TRPB_SALTY
B:
[9-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
---------
63
PsiBlast_CBE
79.79
54%
-10
- C3 -
1K7F
1
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
----------------
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
81
PsiBlast_CBE
79.78
54%
2
- C3 -
1K8Z
2
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
P
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
87
PsiBlast_CBE
79.39
54%
-3
- C3 -
2TRS
2
TRPB_SALTY
B:
[9-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
---------
86
PsiBlast_CBE
79.06
54%
0
- C3 -
2TSY
2
TRPB_SALTY
B:
[9-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
---------
107
HHSearch
79.05
52%
-5
- C3 -
4HT3
21
TRPB_SALTY
B:
[6-394]
-------
N
P
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
S
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
-
R
-
T
T
--
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
------------------
S
G
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
A
R
------
42
PsiBlast_CBE
79.02
54%
-1
- C3 -
1TTQ
2
TRPB_SALTY
B:
[9-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
---------
47
PsiBlast_CBE
78.98
54%
4
- C3 -
1C29
2
TRPB_SALTY
B:
[9-389]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
-----------
43
PsiBlast_CBE
78.57
54%
6
- C3 -
1CX9
2
TRPB_SALTY
B:
[9-389]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
-----------
17
PsiBlast_PDB
77.54
54%
1
- C3 -
2CLM
3
TRPB_SALTY
B:
[8-391]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----
D
I
L
K
--------
14
PsiBlast_PDB
77.04
54%
-2
- C3 -
2WSY
2
TRPB_SALTY
B:
[8-387]
----------
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
---
A
G
-
T
R
T
T
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
K
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
E
-
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
----
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
----------------------
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
--
I
-
N
D
T
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
--
G
E
H
G
A
P
L
K
H
G
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
P
Q
H
A
Y
L
N
S
I
G
R
A
-
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
P
E
-
K
E
Q
L
L
V
V
N
L
S
G
R
G
D
K
D
I
F
T
V
H
----------------
123
Fugue
75.14
50%
-6
- C3 -
2TYS
2
TRPB_SALTY
B:
[3-397]
----
T
L
L
N
P
Y
F
G
E
F
G
G
M
Y
V
P
Q
I
L
M
P
A
L
N
Q
L
E
E
A
F
V
R
A
Q
K
D
P
E
F
Q
A
Q
F
A
D
L
L
K
N
Y
A
G
R
P
T
A
L
T
K
C
Q
N
I
T
A
G
T
R
--
T
T
--
L
Y
L
K
R
E
D
L
L
H
G
G
A
H
T
T
N
Q
V
L
G
Q
A
L
L
A
K
R
M
G
K
S
-
E
I
I
A
E
T
G
A
G
Q
H
G
V
A
S
A
L
A
S
A
L
L
G
L
K
C
R
I
Y
M
G
A
K
D
V
E
R
Q
S
P
N
V
F
R
M
R
L
M
G
A
E
V
I
P
V
H
S
G
---------------
S
A
T
L
K
D
A
C
N
E
A
L
R
D
W
S
G
---
S
Y
E
T
A
H
Y
M
L
G
T
A
A
G
P
H
P
Y
P
T
I
V
R
E
F
Q
R
M
I
G
E
E
T
K
A
Q
I
L
D
K
E
G
R
L
P
D
A
V
I
A
C
V
G
G
G
S
N
A
I
G
M
F
A
--
D
F
IN--
D
T
-
S
V
G
L
I
G
V
E
P
G
G
H
G
I
E
T
GE
H
G
A
P
L
K
H
G
--
R
V
G
I
Y
F
G
M
K
-----------
A
P
M
M
Q
T
A
D
G
Q
I
E
E
S
Y
S
I
S
A
G
L
D
F
P
S
V
G
-
P
Q
H
A
Y
L
N
S
I
G
R
A
D
Y
V
S
I
T
D
D
E
A
L
E
A
F
K
T
L
C
R
H
E
G
I
I
P
A
L
E
S
S
H
A
---
L
A
H
A
L
K
M
M
R
-
E
Q
-
P
E
K
E
Q
L
L
V
V
N
L
S
G
-
R
G
--
D
K
D
I
F
----
T
V
H
D
I
L
K
A
R
G
E
I
93
PsiBlast_CBE
50.20
32%
32
- C3 -
4QYS
1
TRPB2_SULSO
B:
[76-428]
-------------------------------------------------------
G
R
P
T
P
I
I
R
A
K
R
L
E
E
Y
L
G
N
N
I
K
--
I
Y
L
K
M
E
S
Y
T
Y
T
G
S
H
K
I
N
S
A
L
A
H
V
Y
Y
A
K
L
D
N
A
K
F
-
V
T
T
E
T
G
A
G
Q
W
G
S
S
V
A
L
A
S
A
L
F
R
M
K
A
H
I
F
M
V
R
T
S
Y
Y
A
K
P
Y
R
K
Y
M
M
Q
M
Y
G
A
E
V
H
P
S
P
S
D
LT
E
F
G
R
Q
L
L
A
K
DSNH
P
G
S
L
G
I
A
I
S
D
A
V
E
Y
--
A
---
H
K
N
G
G
K
Y
V
V
G
S
V
V
N
S
D
------
I
M
F
K
T
I
A
G
M
E
A
K
K
Q
M
E
L
I
-
G
E
D
P
D
Y
I
I
G
V
V
G
G
G
S
N
Y
A
A
L
A
Y
--
P
F
--
L
-
G
D
---
E
L
R
S
G
K
V
R
R
K
Y
I
A
S
----
G
S
S
E
V
P
K
M
T
K
G
V
Y
K
Y
D
Y
PDTAKLLPMLK
M
Y
T
I
G
S
D
F
---
V
P
P
P
V
Y
A
G
G
L
R
Y
H
G
V
A
P
T
L
S
L
L
I
S
K
G
I
V
-
Q
A
R
D
Y
S
Q
E
E
S
F
K
W
A
K
L
F
S
E
L
E
G
Y
I
P
A
P
E
T
S
H
A
L
P
I
L
A
E
I
A
E
E
A
K
-
K
S
-
G
-
E
R
K
T
V
L
V
S
F
S
G
H
G
L
L
D
L
G
N
Y
A
----
S
V
L
F
K
-------