@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu26740: (2016-07-11 )
MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSLGALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPPDHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVISEMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGDLISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQQPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIFPNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQMKWKGNFLMRALEELPISF
Atome Classification :
(64 SA)
.........10........20........30........40....-....-50........60.......----.70....---....80.--.......90...--.....100.......110.......120.......130.....-.--.140..-......150.......160.......170.......180---....-....--190-........200.......210.......220....-...-230.......240.......250.......260.......270.......280.......290....--...-300.........310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSKEK
K
S
V
T
I
L
T
E
S
QLSSRA
F
K
D
E
A
Y
E
F
Y
K
E
L
R
KSQAL
Y
P
L
SLG-ALGK-G
W
L
I
SRY
D
D
A
I
H
L
L
K
N
E
K
L
----
K
K
N
Y
E
N
V
---
F
TAKEKR--
P
A
LLK
N
E
E
T
L
T
K
--
H
M
LNSDPP
D
H
N
R
L
R
T
L
V
Q
K
A
F
T
H
R
M
I
L
Q
L
E
D
K
I
Q
H
I
A
D
S
L
L
D
K-V--Q
P
-
N
K
F
-
M
N
L
V
D
DYAFP
L
P
I
I
V
I
S
E
M
LGIP
L
E
D
R
Q
K
F
R
V
W
S
Q
A
I
I----DFSD-A
P
E
R
--
L
Q
--EN
D
H
L
L
G
E
F
V
E
Y
L
E
S
L
V
R
K
KRREP
A
G
D
L
I
S
A
L
I
QA-ESE-GTQL
S
T
E
E
L
Y
S
M
I
M
L
L
I
VAGH
E
T
T
V
N
L
I
TN
M
T
Y
A
L
M
CH
H
D
Q
L
E
K
L
R
QQP
D
L
M
N
S
A
I
E
E
A
L
RFHSPV
E
--
L
T
T
-
I
--
R
WTAE
P
F
I
LHGQEIKRK
D
V
I
I
I
S
LASANRDEKIFPNA
D
I
F
D
I
ERKNN
R
H
I
A
FGHGN
H
F
C
L
G
A
Q
L
A
R
L
E
A
K
I
A
I
S
T
L
L
R
RCPN
I
Q
LKGEKK
Q
M
K
WK
G
N
F
L
M
R
A
L
E
ELPISF
10
PsiBlast_PDB
83.59
41%
-12
- C4 -
2BVJ
3
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
D
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
38
PsiBlast_CBE
83.15
41%
-13
- C4 -
4BF4
3
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
23
PsiBlast_CBE
83.11
41%
-12
- C4 -
4UMZ
2
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
6
PsiBlast_PDB
83.01
41%
-12
- C4 -
3ZK5
2
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
22
PsiBlast_CBE
82.96
41%
-14
- C4 -
2WHW
4
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
40
PsiBlast_CBE
82.92
41%
-11
- C4 -
3ZPI
6
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
2
PsiBlast_PDB
82.80
41%
-14
- C4 -
2WI9
2
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
9
PsiBlast_PDB
82.73
41%
-15
- C4 -
4UMZ
2
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
39
PsiBlast_CBE
82.68
41%
-14
- C4 -
4B7S
6
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
32
PsiBlast_CBE
82.67
41%
-15
- C4 -
4BF4
1
PIKC_STRVZ
H:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
LA
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
1
PsiBlast_PDB
82.66
41%
-13
- C4 -
2WHW
2
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
33
PsiBlast_CBE
82.64
41%
-18
- C4 -
4BF4
17
PIKC_STRVZ
G:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
LA
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
15
PsiBlast_PDB
82.64
41%
-14
- C4 -
4B7D
3
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
D
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
37
PsiBlast_CBE
82.63
41%
-14
- C4 -
4BF4
2
PIKC_STRVZ
C:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
LA
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
25
PsiBlast_CBE
82.62
41%
-18
- C4 -
4BF4
17
PIKC_STRVZ
O:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
LA
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
21
PsiBlast_CBE
82.61
41%
-17
- C4 -
2WI9
5
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
8
PsiBlast_PDB
82.59
41%
-18
- C4 -
4BF4
2
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
36
PsiBlast_CBE
82.57
41%
-13
- C4 -
4BF4
2
PIKC_STRVZ
D:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
LA
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
47
PsiBlast_CBE
82.45
41%
-12
- C4 -
2C6H
3
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
D
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
LA
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
7
PsiBlast_PDB
82.40
41%
-12
- C4 -
3ZPI
13
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
44
PsiBlast_CBE
82.39
41%
-13
- C4 -
4B7D
4
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
D
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
LA
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
5
PsiBlast_PDB
82.38
41%
-12
- C4 -
4B7S
14
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
12
PsiBlast_PDB
82.35
41%
-12
- C4 -
2C7X
2
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
D
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
4
PsiBlast_PDB
82.20
41%
-12
- C4 -
2VZM
2
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
41
PsiBlast_CBE
82.11
41%
-13
- C4 -
3ZK5
2
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
11
PsiBlast_PDB
82.05
41%
-11
- C4 -
2C6H
6
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
D
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
43
PsiBlast_CBE
81.87
41%
-16
- C4 -
2VZ7
2
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
42
PsiBlast_CBE
81.62
41%
-13
- C4 -
2VZM
2
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
45
PsiBlast_CBE
81.15
41%
-11
- C4 -
2CD8
2
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
D
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
LA
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
48
PsiBlast_CBE
80.81
41%
-12
- C4 -
2BVJ
2
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
D
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
------
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
46
PsiBlast_CBE
80.69
41%
-14
- C4 -
2CA0
2
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
D
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
LA
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
14
PsiBlast_PDB
80.68
41%
-11
- C4 -
2CD8
2
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
D
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
58
PsiBlast_CBE
80.42
38%
8
- C4 -
3VRM
2
CPVDH_PSEAH
A:
[4-398]
-------
T
T
T
G
T
E
Q
H
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
A
L
P
-
D
-
G
P
-
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
----
S
K
D
W
R
H
T
---
L
P
E
D
Q
R
A
DM
P
A
------
T
P
T
P
--
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
A
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
-
L
--
P
T
-
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
----
D
D
S
P
-
A
------
D
--
D
K
N
A
A
M
G
K
L
H
G
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
-
S
D
E
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
--
Q
A
P
-
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
13
PsiBlast_PDB
80.24
41%
-14
- C4 -
2CA0
2
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
D
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
17
PsiBlast_PDB
79.76
38%
10
- C4 -
3A4H
2
CPVDH_PSEAH
A:
[4-398]
-------
T
T
T
G
T
E
Q
H
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
A
L
P
-
D
-
G
P
-
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
----
S
K
D
W
R
H
T
---
L
P
E
D
Q
R
A
DM
P
A
------
T
P
T
P
--
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
-
L
--
P
T
-
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
----
D
D
S
P
-
A
------
D
--
D
K
N
A
A
M
G
K
L
H
G
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
-
S
D
E
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
--
Q
A
P
-
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
3
PsiBlast_PDB
79.68
41%
-9
- C4 -
2VZ7
2
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
16
PsiBlast_PDB
79.66
38%
8
- C4 -
3A4G
2
CPVDH_PSEAH
A:
[9-398]
------------
E
Q
H
D
L
F
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
A
L
P
-
D
-
G
P
-
V
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
----
S
K
D
W
R
H
T
---
L
P
E
D
Q
R
A
DM
P
A
------
T
P
T
P
--
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
-
L
--
P
T
-
D
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
----
D
D
S
P
-
A
------
D
--
D
K
N
A
A
M
G
K
L
H
G
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
-
S
D
E
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
--
Q
A
P
-
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
75
PsiBlast_CBE
78.54
36%
19
- C4 -
1Z8P
3
CPXJ_SACEN
A:
[3-400]
------------
T
V
P
D
L
E
S
D
S
F
H
V
D
W
Y
R
T
Y
A
E
L
R
E
T
A
P
V
T
P
V
R
F
---
L
G
Q
D
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
SSDP
K
K
K
Y
P
G
V
E
V
E
F
P
A
Y
L
G
F
--
P
E
D
V
R
N
--
Y
F
A
T
--
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
-
V
--
G
D
-
S
G
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
----
V
M
D
---
P
E
R
--
A
E
--
Q
R
G
Q
A
A
R
E
V
V
N
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
R
V
Q
D
D
D
-
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
S
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
E
---
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
--
78
PsiBlast_CBE
77.58
36%
20
- C4 -
1Z8O
3
CPXJ_SACEN
A:
[3-400]
------------
T
V
P
D
L
E
S
D
S
F
H
V
D
W
Y
R
T
Y
A
E
L
R
E
T
A
P
V
T
P
V
R
F
---
L
G
Q
D
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
SSDP
K
K
K
Y
P
G
V
E
V
E
F
P
A
Y
L
G
F
--
P
E
D
V
R
N
--
Y
F
A
T
--
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
-
V
--
G
D
-
S
G
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
----
V
M
D
---
P
E
R
--
A
E
--
Q
R
G
Q
A
A
R
E
V
V
N
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
R
V
Q
D
D
D
-
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
E
---
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
--
76
PsiBlast_CBE
77.27
36%
24
- C4 -
1JIP
2
CPXJ_SACEN
A:
[2-399]
------------
T
V
P
D
L
E
S
D
S
F
H
V
D
W
Y
R
T
Y
A
E
L
R
E
T
A
P
V
T
P
V
R
F
---
L
G
Q
D
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
SSDP
K
K
K
Y
P
G
V
E
V
E
F
P
A
Y
L
G
F
--
P
E
D
V
R
N
--
Y
F
A
T
--
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
-
V
--
G
D
-
S
G
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
----
V
M
D
---
P
E
R
--
A
E
--
Q
R
G
Q
A
A
R
E
V
V
N
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
R
V
Q
D
D
D
-
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
S
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
E
---
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
--
77
PsiBlast_CBE
77.01
36%
22
- C4 -
1JIO
2
CPXJ_SACEN
A:
[2-399]
------------
T
V
P
D
L
E
S
D
S
F
H
V
D
W
Y
R
T
Y
A
E
L
R
E
T
A
P
V
T
P
V
R
F
---
L
G
Q
D
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
SSDP
K
K
K
Y
P
G
V
E
V
E
F
P
A
Y
L
G
F
--
P
E
D
V
R
N
--
Y
F
A
T
--
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
-
V
--
G
D
-
S
G
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
----
V
M
D
---
P
E
R
--
A
E
--
Q
R
G
Q
A
A
R
E
V
V
N
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
R
V
Q
D
D
D
-
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
E
---
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
--
74
PsiBlast_CBE
76.74
36%
19
- C4 -
1Z8Q
3
CPXJ_SACEN
A:
[3-400]
------------
T
V
P
D
L
E
S
D
S
F
H
V
D
W
Y
R
T
Y
A
E
L
R
E
T
A
P
V
T
P
V
R
F
---
L
G
Q
D
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
SSDP
K
K
K
Y
P
G
V
E
V
E
F
P
A
Y
L
G
F
--
P
E
D
V
R
N
--
Y
F
A
T
--
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
-
V
--
G
D
-
S
G
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
----
V
M
D
---
P
E
R
--
A
E
--
Q
R
G
Q
A
A
R
E
V
V
N
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
R
V
Q
D
D
D
-
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
T
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
E
---
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
--
81
PsiBlast_CBE
76.27
35%
21
- C4 -
1JIN
2
CPXJ_SACEN
A:
[2-399]
------------
T
V
P
D
L
E
S
D
S
F
H
V
D
W
Y
S
T
Y
A
E
L
R
E
T
A
P
V
T
P
V
R
F
---
L
G
Q
D
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
SSDP
K
K
K
Y
P
G
V
E
V
E
F
P
A
Y
L
G
F
--
P
E
D
V
R
N
--
Y
F
A
T
--
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
-
V
--
G
D
-
S
G
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
A
A
R
G
A
F
G
R
W
S
S
E
I
L
----
V
M
D
---
P
E
R
--
A
E
--
Q
R
G
Q
A
A
R
E
V
V
N
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
S
V
Q
D
D
D
-
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
A
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
E
---
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
S
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
--
80
PsiBlast_CBE
75.75
35%
18
- C4 -
1OXA
2
CPXJ_SACEN
A:
[2-399]
------------
T
V
P
D
L
E
S
D
S
F
H
V
D
W
Y
S
T
Y
A
E
L
R
E
T
A
P
V
T
P
V
R
F
---
L
G
Q
D
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
SSDP
K
K
K
Y
P
G
V
E
V
E
F
P
A
Y
L
G
F
--
P
E
D
V
R
N
--
Y
F
A
T
--
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
-
V
--
G
D
-
S
G
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
A
A
R
G
A
F
G
R
W
S
S
E
I
L
----
V
M
D
---
P
E
R
--
A
E
--
Q
R
G
Q
A
A
R
E
V
V
N
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
S
V
Q
D
D
D
-
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
A
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
E
---
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
S
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
--
82
PsiBlast_CBE
75.60
35%
17
- C4 -
1EUP
3
CPXJ_SACEN
A:
[2-399]
------------
T
V
P
D
L
E
S
D
S
F
H
V
D
W
Y
S
T
Y
A
E
L
R
E
T
A
P
V
T
P
V
R
F
---
L
G
Q
D
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
SSDP
K
K
K
Y
P
G
V
E
V
E
F
P
A
Y
L
G
F
--
P
E
D
V
R
N
--
Y
F
A
T
--
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
-
V
--
G
D
-
S
G
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
A
A
R
G
A
F
G
R
W
S
S
E
I
L
----
V
M
D
---
P
E
R
--
A
E
--
Q
R
G
Q
A
A
R
E
V
V
N
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
S
V
Q
D
D
D
-
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
A
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
E
---
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
S
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
--
99
PsiBlast_CBE
75.42
34%
-8
- C4 -
2Y5Z
8
MYCG_MICGR
A:
[43-417]
-----------------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
-
Y
G
E
E
-
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
----
V
R
G
P
S
M
T
---
R
D
E
P
R
T
R
--
P
E
M
V
K
G
--------
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
-
M
--
A
A
T
G
Q
P
-
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
----
S
T
A
E
V
T
A
E
E
--
M
Q
--
E
A
A
E
---
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
-
R
D
Q
-
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
-
V
P
L
G
--
V
G
T
-
A
F
P
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
V
W
83
PsiBlast_CBE
75.39
35%
19
- C4 -
1EGY
3
CPXJ_SACEN
A:
[2-399]
------------
T
V
P
D
L
E
S
D
S
F
H
V
D
W
Y
S
T
Y
A
E
L
R
E
T
A
P
V
T
P
V
R
F
---
L
G
Q
D
A
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
SSDP
K
K
K
Y
P
G
V
E
V
E
F
P
A
Y
L
G
F
--
P
E
D
V
R
N
--
Y
F
A
T
--
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
-
V
--
G
D
-
S
G
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
A
A
R
G
A
F
G
R
W
S
S
E
I
L
----
V
M
D
---
P
E
R
--
A
E
--
Q
R
G
Q
A
A
R
E
V
V
N
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
S
V
Q
D
D
D
-
D
G
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
A
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
P
E
---
T
T
-
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
S
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
L
G
I
D
A
D
D
V
V
W
R
R
S
L
L
L
R
G
I
D
H
L
P
V
--
79
PsiBlast_CBE
75.39
38%
-36
- C4 -
4RM4
1
YJIB_BACSU
A:
[27-374]
--------------------------
F
P
W
Y
E
S
M
R
K
D
A
---
P
V
S
F
D
-
E
E
N
Q
-
V
W
S
V
F
L
Y
D
D
V
K
K
V
V
G
D
K
E
L
--------------
F
S
S
-------
C
M
-------
G
N
--
S
I
I
N
M
D
P
P
K
H
T
K
I
R
S
V
V
N
K
A
F
T
P
R
V
M
K
Q
W
E
P
R
I
Q
E
I
T
D
E
L
I
Q
K
-
F
--
Q
G
-
R
S
E
-
F
D
L
V
H
D
F
S
Y
P
L
P
V
I
V
I
S
E
L
L
G
V
P
S
A
H
M
E
Q
F
K
A
W
S
D
L
L
V
STPK
D
K
S
E
-
E
A
E
K
A
F
L
E
--
E
R
D
K
C
E
E
E
L
A
A
F
F
A
G
I
I
E
E
K
R
N
K
P
E
Q
D
I
I
S
I
L
V
E
------
G
E
K
L
S
G
E
E
L
I
P
F
C
T
L
L
L
V
A
G
N
E
T
T
T
N
L
I
S
N
A
M
Y
S
I
L
E
T
P
G
V
Y
E
E
L
R
S
H
P
E
L
M
P
Q
A
V
E
E
A
L
R
F
R
A
P
A
P
--
V
L
R
----
R
I
A
K
R
D
T
E
I
G
G
H
L
I
K
E
G
D
M
V
L
A
F
V
A
S
A
N
R
D
E
A
K
F
D
R
P
H
M
F
D
I
R
R
H
P
N
P
H
I
A
F
G
H
G
I
H
F
C
L
G
A
P
L
A
R
L
E
A
N
I
A
L
T
S
L
I
S
A
F
P
H
M
E
--------------------------
90
PsiBlast_CBE
74.81
34%
-12
- C4 -
3ZSN
7
MYCG_MICGR
A:
[43-417]
-----------------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
-
Y
G
E
E
-
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
----
V
R
G
P
S
M
T
---
R
D
E
P
R
T
R
--
P
E
M
V
K
G
--------
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
-
M
--
A
A
T
G
Q
P
-
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
----
S
T
A
E
V
T
A
E
E
--
M
Q
--
E
A
A
E
---
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
-
R
D
Q
-
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
-
V
P
L
G
--
V
G
T
-
A
A
P
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
V
W
102
PsiBlast_CBE
74.74
34%
-10
- C4 -
2Y46
5
MYCG_MICGR
C:
[43-417]
-----------------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
-
Y
G
E
E
-
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
----
V
R
G
P
S
M
T
---
R
D
E
P
R
T
R
--
P
E
M
V
K
G
--------
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
-
M
--
A
A
T
G
Q
P
-
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
----
S
T
A
E
V
T
A
E
E
--
M
Q
--
E
A
A
E
---
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
-
R
D
Q
-
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
-
V
P
L
G
--
V
G
T
-
A
FP
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
V
W
88
PsiBlast_CBE
74.68
34%
-12
- C4 -
3ZSN
6
MYCG_MICGR
C:
[43-417]
-----------------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
-
Y
G
E
E
-
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
----
V
R
G
P
S
M
T
---
R
D
E
P
R
T
R
--
P
E
M
V
K
G
--------
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
-
M
--
A
A
T
G
Q
P
-
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
----
S
T
A
E
V
T
A
E
E
--
M
Q
--
E
A
A
E
---
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
-
R
D
Q
-
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
-
V
P
L
G
--
V
G
T
-
A
AP
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
V
W
84
PsiBlast_CBE
74.55
35%
-25
- C4 -
4Z5P
2
?
B:
[21-400]
------------------------
E
I
H
P
K
F
A
E
L
R
E
T
D
P
L
A
R
V
R
L
P
-
Y
G
G
E
-
G
W
M
V
T
R
Y
D
D
V
--
R
A
A
N
S
D
P
----
R
F
S
R
A
Q
I
---
G
E
D
T
P
R
T
--
T
P
-----
D
T
I
------
L
S
L
D
P
P
E
H
T
R
L
R
R
L
L
S
K
A
F
T
A
R
R
M
G
A
M
Q
S
W
L
E
E
L
F
A
G
L
L
D
G
-
V
--
E
R
-
T
G
H
P
A
D
I
V
R
D
L
A
Q
P
F
T
I
A
V
I
C
R
L
L
G
V
P
Y
E
D
R
G
R
F
Q
H
W
S
E
V
I
M
------
S
T
-
T
A
Y
S
--
K
E
--
E
A
V
S
A
D
A
S
I
R
A
Y
L
A
D
L
V
S
A
R
R
A
A
P
H
D
D
L
L
G
V
L
V
S
A
-
R
D
D
-
D
D
R
L
T
E
D
E
L
I
T
F
G
V
T
L
L
V
A
G
H
E
T
S
A
H
Q
L
G
N
M
V
Y
A
L
L
T
H
E
D
Q
L
S
L
L
R
E
Q
P
E
L
L
P
R
A
V
E
E
L
L
R
F
-
V
P
L
G
NG
V
G
N
-
A
--
R
I
A
L
E
D
V
E
L
S
G
G
T
V
R
A
G
E
G
V
V
A
A
A
V
N
A
N
R
D
P
R
A
F
D
D
P
D
R
L
D
I
T
R
E
K
N
P
H
L
A
F
G
H
G
A
H
Y
C
L
G
A
Q
L
A
R
M
E
L
R
V
A
I
G
G
L
L
E
R
F
P
G
L
R
L
A
V
P
A
D
Q
V
E
W
K
T
G
G
L
F
R
G
P
Q
R
L
P
I
A
W
85
PsiBlast_CBE
74.44
35%
-24
- C4 -
4Z5P
1
?
A:
[21-400]
------------------------
E
I
H
P
K
F
A
E
L
R
E
T
D
P
L
A
R
V
R
L
P
-
Y
G
G
E
-
G
W
M
V
T
R
Y
D
D
V
--
R
A
A
N
S
D
P
----
R
F
S
R
A
Q
I
---
G
E
D
T
P
R
T
--
T
P
-----
D
T
I
------
L
S
L
D
P
P
E
H
T
R
L
R
R
L
L
S
K
A
F
T
A
R
R
M
G
A
M
Q
S
W
L
E
E
L
F
A
G
L
L
D
G
-
V
--
E
R
-
T
G
H
P
A
D
I
V
R
D
L
A
Q
P
F
T
I
A
V
I
C
R
L
L
G
V
P
Y
E
D
R
G
R
F
Q
H
W
S
E
V
I
M
------
S
T
-
T
A
Y
S
--
K
E
--
E
A
V
S
A
D
A
S
I
R
A
Y
L
A
D
L
V
S
A
R
R
A
A
P
H
D
D
L
L
G
V
L
V
S
A
-
R
D
D
-
D
D
R
L
T
E
D
E
L
I
T
F
G
V
T
L
L
V
A
G
H
E
T
S
A
H
Q
L
G
N
M
V
Y
A
L
L
T
H
E
D
Q
L
S
L
L
R
E
Q
P
E
L
L
P
R
A
V
E
E
L
L
R
F
-
V
P
L
G
NG
V
G
N
-
A
--
R
I
A
L
E
D
V
E
L
S
G
G
T
V
R
A
G
E
G
V
V
A
A
A
V
N
A
N
R
D
P
R
A
F
D
D
P
D
R
L
D
I
T
R
E
K
N
P
H
L
A
F
G
H
G
A
H
Y
C
L
G
A
Q
L
A
R
M
E
L
R
V
A
I
G
G
L
L
E
R
F
P
G
L
R
L
A
V
P
A
D
Q
V
E
W
K
T
G
G
L
F
R
G
P
Q
R
L
P
I
A
W
89
PsiBlast_CBE
74.42
34%
-11
- C4 -
3ZSN
6
MYCG_MICGR
B:
[43-417]
-----------------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
-
Y
G
E
E
-
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
----
V
R
G
P
S
M
T
---
R
D
E
P
R
T
R
--
P
E
M
V
K
G
--------
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
-
M
--
A
A
T
G
Q
P
-
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
----
S
T
A
E
V
T
A
E
E
--
M
Q
--
E
A
A
E
---
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
-
R
D
Q
-
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
-
V
P
L
G
--
V
G
T
-
A
AP
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
V
W
104
PsiBlast_CBE
73.78
34%
-7
- C4 -
2Y46
6
MYCG_MICGR
A:
[43-417]
-----------------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
-
Y
G
E
E
-
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
----
V
R
G
P
S
M
T
---
R
D
E
P
R
T
R
--
P
E
M
V
K
G
--------
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
-
M
--
A
A
T
G
Q
P
-
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
----
S
T
A
E
V
T
A
E
E
--
M
Q
--
E
A
A
E
---
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
-
R
D
Q
-
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
-
V
P
L
G
--
V
G
T
-
A
F
P
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
V
W
100
PsiBlast_CBE
73.75
34%
-9
- C4 -
2Y5N
7
MYCG_MICGR
B:
[43-417]
-----------------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
-
Y
G
E
E
-
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
----
V
R
G
P
S
M
T
---
R
D
E
P
R
T
R
--
P
E
M
V
K
G
--------
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
-
M
--
A
A
T
G
Q
P
-
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
----
S
T
A
E
V
T
A
E
E
--
M
Q
--
E
A
A
E
---
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
-
R
D
Q
-
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
-
V
P
L
G
--
V
G
T
-
A
F
P
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
V
W
96
PsiBlast_CBE
73.68
34%
-6
- C4 -
2Y98
7
MYCG_MICGR
A:
[43-417]
-----------------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
-
Y
G
E
E
-
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
----
V
R
G
P
S
M
T
---
R
D
E
P
R
T
R
--
P
E
M
V
K
G
--------
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
-
M
--
A
A
T
G
Q
P
-
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
----
S
T
A
E
V
T
A
E
E
--
M
Q
--
E
A
A
E
---
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
-
R
D
Q
-
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
-
V
P
L
G
--
V
G
T
-
A
F
P
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
V
W
103
PsiBlast_CBE
73.46
34%
-9
- C4 -
2Y46
5
MYCG_MICGR
B:
[43-417]
-----------------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
-
Y
G
E
E
-
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
----
V
R
G
P
S
M
T
---
R
D
E
P
R
T
R
--
P
E
M
V
K
G
--------
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
-
M
--
A
A
T
G
Q
P
-
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
----
S
T
A
E
V
T
A
E
E
--
M
Q
--
E
A
A
E
---
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
-
R
D
Q
-
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
-
V
P
L
G
--
V
G
T
-
A
FP
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
V
W
105
PsiBlast_CBE
73.39
34%
-6
- C4 -
4AW3
8
MYCG_MICGR
B:
[43-417]
-----------------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
-
Y
G
E
E
-
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
----
V
R
G
P
S
M
T
---
R
D
E
P
R
T
R
--
P
E
M
V
K
G
--------
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
-
M
--
A
A
T
G
Q
P
-
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
----
S
T
A
E
V
T
A
E
E
--
M
Q
--
E
A
A
E
---
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
-
R
D
Q
-
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
-
V
P
L
G
--
V
G
T
-
A
VP
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
V
W
97
PsiBlast_CBE
73.27
34%
-7
- C4 -
2Y5Z
6
MYCG_MICGR
C:
[43-417]
-----------------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
-
Y
G
E
E
-
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
----
V
R
G
P
S
M
T
---
R
D
E
P
R
T
R
--
P
E
M
V
K
G
--------
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
-
M
--
A
A
T
G
Q
P
-
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
----
S
T
A
E
V
T
A
E
E
--
M
Q
--
E
A
A
E
---
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
-
R
D
Q
-
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
-
V
P
L
G
--
V
G
T
-
A
FP
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
V
W
106
PsiBlast_CBE
73.02
34%
-8
- C4 -
4AW3
8
MYCG_MICGR
A:
[43-417]
-----------------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
-
Y
G
E
E
-
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
----
V
R
G
P
S
M
T
---
R
D
E
P
R
T
R
--
P
E
M
V
K
G
--------
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
-
M
--
A
A
T
G
Q
P
-
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
----
S
T
A
E
V
T
A
E
E
--
M
Q
--
E
A
A
E
---
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
-
R
D
Q
-
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
-
V
P
L
G
--
V
G
T
-
A
V
P
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
V
W
98
PsiBlast_CBE
72.91
34%
-8
- C4 -
2Y5Z
7
MYCG_MICGR
B:
[43-417]
-----------------------------
Y
G
E
L
Q
E
T
E
P
V
S
R
V
R
P
P
-
Y
G
E
E
-
A
W
L
V
T
R
Y
E
D
V
R
A
V
L
G
D
G
R
F
----
V
R
G
P
S
M
T
---
R
D
E
P
R
T
R
--
P
E
M
V
K
G
--------
G
L
L
S
M
D
P
P
E
H
S
R
L
R
R
L
V
V
K
A
F
T
A
R
R
A
E
S
L
R
P
R
A
R
E
I
A
H
E
L
V
D
Q
-
M
--
A
A
T
G
Q
P
-
A
D
L
V
A
M
F
A
R
Q
L
P
V
R
V
I
C
E
L
L
G
V
P
S
A
D
H
D
R
F
T
R
W
S
G
A
F
L
----
S
T
A
E
V
T
A
E
E
--
M
Q
--
E
A
A
E
---
Q
A
Y
A
Y
M
G
D
L
I
D
R
R
R
K
E
P
T
D
D
L
V
S
A
L
V
Q
A
-
R
D
Q
-
Q
D
S
L
S
E
Q
E
L
L
D
L
A
I
G
L
L
V
A
G
Y
E
S
T
T
T
Q
I
A
D
F
V
Y
L
L
M
T
R
P
E
L
R
R
Q
L
L
D
R
P
E
L
I
P
S
A
V
E
E
L
T
R
W
-
V
P
L
G
--
V
G
T
-
A
F
P
R
Y
A
V
E
D
V
T
L
R
G
V
T
I
R
A
G
E
P
V
L
A
S
T
G
A
A
N
R
D
Q
A
Q
F
P
D
A
D
R
I
D
V
D
R
T
P
N
Q
H
L
G
F
G
H
G
V
H
H
C
L
G
A
P
L
A
R
V
E
L
Q
V
A
L
E
V
L
L
Q
R
L
P
G
I
R
L
G
I
P
E
T
Q
L
R
W
S
E
G
M
L
L
R
G
P
L
E
L
P
V
V
W
86
PsiBlast_CBE
70.36
37%
5
- C4 -
4XE3
8
?
B:
[31-407]
-----------------------------
Y
A
E
L
R
R
D
E
P
V
S
R
V
R
L
P
Y
G
E
G
T
-
A
W
L
V
T
R
M
S
D
A
R
I
V
L
G
D
S
R
F
----
S
----------
T
A
A
A
T
D
--
P
A
T
P
R
M
F
P
T
P
P
E
PD
G
V
L
A
Q
D
P
P
D
H
T
R
L
R
R
L
V
G
K
A
F
T
A
R
R
V
E
E
M
R
P
R
V
R
S
L
V
D
S
L
L
D
D
M
V
--
A
H
-
G
S
P
-
A
D
L
V
E
F
L
A
V
P
F
P
V
A
V
I
C
E
L
L
G
V
P
L
E
D
R
D
L
F
R
T
F
S
D
A
M
L
----
S
S
T
-----
R
--
L
T
AA
E
I
Q
R
V
Q
Q
D
F
M
V
Y
M
D
G
L
V
A
Q
R
R
D
A
P
T
E
D
L
L
G
A
L
A
L
A
-
T
D
N
-
D
D
H
L
T
K
G
E
I
V
N
M
G
V
S
L
L
I
A
G
H
E
T
S
V
N
Q
I
T
N
L
V
H
L
L
L
T
E
R
K
R
Y
E
S
L
V
A
D
P
A
L
V
P
A
A
V
E
E
M
L
R
Y
T
P
L
V
S
--
A
G
S
F
V
--
R
V
A
T
E
D
V
E
L
S
T
V
T
V
R
A
G
E
P
C
V
V
H
F
A
S
A
N
R
D
E
E
V
F
D
H
A
D
E
L
D
F
H
R
E
R
N
P
H
I
A
F
G
H
G
A
H
H
C
I
G
A
Q
L
G
R
L
E
L
Q
E
A
L
S
A
L
V
R
R
F
P
T
L
D
L
A
E
P
V
A
G
L
K
W
K
Q
G
M
L
I
R
G
L
E
R
Q
I
V
S
W
87
PsiBlast_CBE
70.10
37%
8
- C4 -
4XE3
11
?
A:
[31-407]
-----------------------------
Y
A
E
L
R
R
D
E
P
V
S
R
V
R
L
P
Y
G
E
G
T
-
A
W
L
V
T
R
M
S
D
A
R
I
V
L
G
D
S
R
F
----
S
----------
T
A
A
A
T
D
--
P
A
T
P
R
M
F
P
T
P
P
E
PD
G
V
L
A
Q
D
P
P
D
H
T
R
L
R
R
L
V
G
K
A
F
T
A
R
R
V
E
E
M
R
P
R
V
R
S
L
V
D
S
L
L
D
D
M
V
--
A
H
-
G
S
P
-
A
D
L
V
E
F
L
A
V
P
F
P
V
A
V
I
C
E
L
L
G
V
P
L
E
D
R
D
L
F
R
T
F
S
D
A
M
L
----
S
S
T
-----
R
--
L
T
AA
E
I
Q
R
V
Q
Q
D
F
M
V
Y
M
D
G
L
V
A
Q
R
R
D
A
P
T
E
D
L
L
G
A
L
A
L
A
-
T
D
N
-
D
D
H
L
T
K
G
E
I
V
N
M
G
V
S
L
L
I
A
G
H
E
T
S
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