@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu29080: (2016-07-16 )
MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFARKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTDGTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVKTALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAGGSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK
Atome Classification :
(68 SA)
.........10........20..-----......30.-.......40........50........60.....-.-------.-.70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210..--.....220..---.....230.......240.......-250.-........260.......270....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPELP
E
V
E
T
V
R
R
T
L
T
G
L
VKG
K
T
I
-----
K
S
V
E
IRW
P
N
-IIKRPA
E
P
E
E
F
A
R
K
L
A
G
E
T
I
Q
S
I
GRRG
K
F
L
L
F
HL-
D
-------
H
-
Y
V
M
V
S
H
L
RMEGKYGLHQAEEPDDK
H
V
H
V
I
F
T
MTDG
T
Q
L
R
Y
R
D
V
R
KFGT
M
H
L
FKPGEEAGEL
P
L
S
QLGPEP
D
A
E
E
F
T
S
A
Y
L
K
D
R
L
A
KT
N
R
A
V
K
T
A
LLDQK
T
V
V
GL
G
N
I
Y
V
D
E
A
L
F
RAGVHPETKANQLS
D
K
T
I
K
T
L
H
A
E
I
K
N
T
L
Q
E
A
--
I
DAG
G
S
T
V
R
S
---
Y
I
NSQGE
I
G
M
F
Q
L
Q
H
F
VYGKKDE
P
C
-
K
--
N
-
C
G
T
M
I
S
K
I
VVGGRG
T
H
F
C
A
KCQTKK
12
PsiBlast_PDB
85.77
55%
-77
- C8 -
2F5S
3
?
A:
[2-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
G
G
S
T
V
R
T
---
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
18
PsiBlast_PDB
85.56
55%
-79
- C8 -
3GPY
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
G
G
S
T
V
R
T
---
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
19
PsiBlast_PDB
85.06
55%
-77
- C8 -
3GQ4
4
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
G
G
S
T
V
R
T
---
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
4
PsiBlast_PDB
85.02
56%
-84
- C8 -
1L2C
3
?
A:
[2-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
G
G
S
-----------------
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
7
PsiBlast_PDB
84.96
55%
-78
- C8 -
1R2Z
3
?
A:
[2-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
G
G
S
T
V
R
T
---
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
36
PsiBlast_CBE
84.88
54%
-93
- C8 -
3U6E
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
25
PsiBlast_CBE
84.71
55%
-97
- C8 -
3SAW
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
A
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
23
PsiBlast_CBE
84.65
55%
-93
- C8 -
3SBJ
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
6
PsiBlast_PDB
84.59
55%
-77
- C8 -
1R2Y
3
?
A:
[2-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
G
G
S
T
V
R
T
---
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
1
PsiBlast_PDB
84.59
56%
-84
- C8 -
1L1T
3
?
A:
[2-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
G
G
S
-----------------
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
39
PsiBlast_CBE
84.51
54%
-91
- C8 -
4G4R
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
A
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
11
PsiBlast_PDB
84.48
55%
-74
- C8 -
2F5Q
3
?
A:
[2-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
G
G
S
T
V
R
T
---
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
69
HHSearch
84.41
55%
-93
- C8 -
3U6P
3
?
A:
[1-273]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
--
29
PsiBlast_CBE
84.41
54%
-93
- C8 -
4G4O
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
A
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
5
PsiBlast_PDB
84.33
56%
-81
- C8 -
1L2D
3
?
A:
[2-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
G
G
S
-----------------
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
21
PsiBlast_CBE
84.20
55%
-79
- C8 -
3JR5
4
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
C
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
G
G
S
T
V
R
T
---
Y
V
N
T
Q
G
E
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
3
PsiBlast_PDB
84.16
56%
-79
- C8 -
1L2B
4
?
A:
[2-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
G
G
S
T
V
R
------------
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
15
PsiBlast_PDB
84.09
55%
-93
- C8 -
3SAV
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
31
PsiBlast_CBE
84.08
54%
-96
- C8 -
3U6Q
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
2
PsiBlast_PDB
84.03
56%
-84
- C8 -
1L1Z
3
?
A:
[2-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
G
G
S
T
V
-------------
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
32
PsiBlast_CBE
83.97
54%
-94
- C8 -
3U6P
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
90
Fugue
83.89
55%
-83
- C8 -
1L1Z
3
?
A:
[2-274]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
G
G
S
T
V
-------------
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
R
--
24
PsiBlast_CBE
83.85
55%
-94
- C8 -
3GP1
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
37
PsiBlast_CBE
83.82
54%
-94
- C8 -
3U6D
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
9
PsiBlast_PDB
83.81
55%
-95
- C8 -
2F5O
4
?
A:
[2-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
14
PsiBlast_PDB
83.80
55%
-97
- C8 -
3SAU
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
-------------------------
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
38
PsiBlast_CBE
83.76
54%
-91
- C8 -
3U6C
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
17
PsiBlast_PDB
83.73
55%
-96
- C8 -
3GQ5
5
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
34
PsiBlast_CBE
83.70
54%
-93
- C8 -
3U6M
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
33
PsiBlast_CBE
83.63
54%
-94
- C8 -
3U6O
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
30
PsiBlast_CBE
83.59
54%
-97
- C8 -
3U6S
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
13
PsiBlast_PDB
83.56
55%
-94
- C8 -
3SAR
7
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
-----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
22
PsiBlast_CBE
83.50
55%
-93
- C8 -
4G4N
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
A
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
-----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
27
PsiBlast_CBE
83.48
55%
-93
- C8 -
3SAS
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
A
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
-----------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
40
PsiBlast_CBE
83.34
51%
-93
- C8 -
3GQ3
3
?
A:
[1-256]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
----------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
16
PsiBlast_PDB
83.32
55%
-95
- C8 -
3GPP
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
-------------------------
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
8
PsiBlast_PDB
83.32
55%
-92
- C8 -
2F5N
5
?
A:
[2-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
41
PsiBlast_CBE
83.29
51%
-94
- C8 -
3GPX
3
?
A:
[1-256]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
35
PsiBlast_CBE
82.92
54%
-94
- C8 -
3U6L
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
26
PsiBlast_CBE
82.90
55%
-90
- C8 -
3SAT
4
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
A
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
-------------------------
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
20
PsiBlast_PDB
82.70
55%
-83
- C8 -
3JR4
3
?
A:
[1-272]
-
P
Q
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
Q
T
V
V
A
G
F
G
C
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
G
G
S
T
-------------
A
G
T
F
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
42
PsiBlast_CBE
82.49
51%
-91
- C8 -
3GO8
3
?
A:
[1-256]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
------------------------
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
28
PsiBlast_CBE
82.19
55%
-89
- C8 -
4G4Q
3
?
A:
[1-272]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
A
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
K
----------------------
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
43
PsiBlast_CBE
81.85
51%
-92
- C8 -
3GPU
3
?
A:
[1-255]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
-------------------------
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
10
PsiBlast_PDB
81.73
55%
-92
- C8 -
2F5P
3
?
A:
[2-273]
-
P
E
L
P
E
V
E
T
I
R
R
T
L
L
P
L
I
V
G
K
T
I
-----
E
D
V
R
I
F
W
P
N
-
I
I
R
H
P
R
D
S
E
A
F
A
A
R
M
I
G
Q
T
V
R
G
L
E
R
R
G
K
F
L
K
F
L
L
-
D
-------
R
-
D
A
L
I
S
H
L
R
M
E
G
R
Y
A
V
A
S
A
L
E
P
L
E
P
H
T
H
V
V
F
C
F
T
D
G
S
E
L
R
Y
R
D
V
R
K
F
G
T
M
H
V
Y
A
K
E
E
A
D
R
R
P
P
L
A
E
L
G
P
E
P
L
S
P
A
F
S
P
A
V
L
A
E
R
A
V
K
T
K
R
S
V
K
A
L
L
L
D
C
T
V
V
A
G
F
G
N
I
Y
V
D
E
S
L
F
R
A
G
I
L
P
G
R
P
A
A
S
L
S
S
K
E
I
E
R
L
H
E
E
M
V
A
T
I
G
E
A
--
V
M
----------------------
Q
H
H
L
Y
V
Y
G
R
Q
G
N
P
C
-
K
--
R
-
C
G
T
P
I
E
K
T
V
V
A
G
R
G
T
H
Y
C
P
R
C
Q
---
70
HHSearch
76.60
40%
-89
- C8 -
1K82
4
FPG_ECOLI
A:
[1-268]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
G
A
T
I
-----
L
H
A
V
V
R
N
G
R
-
L
R
W
-
P
--
V
S
E
E
I
Y
R
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
L
-
P
-------
E
-
G
W
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
K
E
L
E
--
G
H
N
V
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
--
I
E
Q
G
G
T
T
L
K
-----------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
-
R
--
V
-
C
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
K
--
47
PsiBlast_CBE
74.58
45%
4
- C8 -
4PCZ
4
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
-----
I
S
I
E
A
T
Y
P
R
-
M
V
L
T
G
F
E
--
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
-
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
-
Q
L
I
Y
A
D
V
R
K
F
G
T
W
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
--
I
K
L
G
G
S
S
I
R
T
---
Y
-
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
-
S
--
G
-
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
-
51
PsiBlast_CBE
73.92
45%
5
- C8 -
2XZU
4
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
-----
I
S
I
E
A
T
Y
P
R
-
M
V
L
T
G
F
E
--
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
-
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
-
Q
L
I
Y
A
D
V
R
K
F
G
T
W
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
--
I
K
L
G
G
S
---------
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
-
S
--
R
-
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
-
54
PsiBlast_CBE
73.78
45%
-0
- C8 -
1PM5
6
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
-----
I
S
I
E
A
T
Y
P
R
-
M
V
L
T
G
F
E
--
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
-
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
-
Q
L
I
Y
A
D
V
R
K
F
G
T
W
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
--
I
K
L
G
G
S
S
I
R
T
---
Y
-
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
-
S
--
R
-
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
-
45
PsiBlast_CBE
73.77
46%
2
- C8 -
4CIS
3
?
B:
[2-272]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
-----
I
S
I
E
A
T
Y
P
R
-
M
V
L
T
G
F
E
--
Q
L
K
K
E
L
T
G
K
I
I
Q
G
I
I
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
-
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
S
D
G
-
Q
L
I
Y
A
D
V
R
K
F
G
T
W
E
L
I
S
T
D
Q
V
L
P
Y
F
L
N
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
A
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
--
I
K
L
G
G
S
S
I
R
--------
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
-
S
--
R
-
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
F
C
Q
Q
K
-
44
PsiBlast_CBE
73.73
46%
-1
- C8 -
1TDZ
4
FPG_LACLC
A:
[3-272]
--
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
-----
I
S
I
E
A
T
Y
P
R
-
M
V
L
T
G
F
E
--
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
-
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
-
Q
L
I
Y
A
D
V
R
K
F
G
T
W
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
--
I
K
L
G
G
S
S
I
---------
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
-
S
--
R
-
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
-
56
PsiBlast_CBE
73.41
45%
-2
- C8 -
1PJJ
6
FPG_LACLC
A:
[2-271]
--
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
-----
I
S
I
E
A
T
Y
P
R
-
M
V
L
T
G
F
E
--
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
-
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
-
Q
L
I
Y
A
D
V
R
K
F
G
T
W
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
--
I
K
L
G
G
S
S
I
R
T
---
Y
-
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
-
S
--
R
-
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
-
53
PsiBlast_CBE
73.34
45%
4
* C8 *
1XC8
4
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
-----
I
S
I
E
A
T
Y
P
R
-
M
V
L
T
G
F
E
--
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
-
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
-
Q
L
I
Y
A
D
V
R
K
F
G
T
W
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
--
I
K
L
G
G
S
S
I
R
T
---
Y
-
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
-
S
--
R
-
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
-
55
PsiBlast_CBE
72.98
45%
0
- C8 -
1PJI
7
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
-----
I
S
I
E
A
T
Y
P
R
-
M
V
L
T
G
F
E
--
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
-
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
-
Q
L
I
Y
A
D
V
R
K
F
G
T
W
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
--
I
K
L
G
G
S
S
--------
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
-
S
--
R
-
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
-
58
PsiBlast_CBE
72.84
45%
7
- C8 -
4PD2
3
FPG_LACLC
A:
[1-272]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
-----
I
S
I
E
A
T
Y
P
R
-
M
V
L
T
G
F
E
--
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
-
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
-
Q
L
I
Y
A
D
V
R
K
F
G
T
W
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
--
I
K
L
G
G
S
S
I
R
T
---
Y
-
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
S
R
--
G
-
H
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
-
46
PsiBlast_CBE
72.81
46%
-2
- C8 -
4CIS
4
?
A:
[2-272]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
-----
I
S
I
E
A
T
Y
P
R
-
M
V
L
T
G
F
E
--
Q
L
K
K
E
L
T
G
K
I
I
Q
G
I
I
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
-
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
S
D
G
-
Q
L
I
Y
A
D
V
R
K
F
G
T
W
E
L
I
S
T
D
Q
V
L
P
Y
F
L
N
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
A
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
--
I
K
L
G
G
S
S
I
------------
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
-
S
--
R
-
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
F
C
Q
Q
K
-
71
HHSearch
72.73
46%
7
- C8 -
4PD2
3
FPG_LACLC
A:
[1-272]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
-----
I
S
I
E
A
T
Y
P
R
-
M
V
L
T
G
--
F
E
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
-
G
D------
D
-
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
-
G
Q
L
I
Y
A
D
V
R
K
F
G
T
W
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
--
I
K
L
G
G
S
S
I
R
T
---
Y
S
-
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
-
S
--
R
G
H
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
-
48
PsiBlast_CBE
72.60
45%
2
- C8 -
4PDI
3
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
-----
I
S
I
E
A
T
Y
P
R
-
M
V
L
T
G
F
E
--
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
-
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
-
Q
L
I
Y
A
D
V
R
K
F
G
T
W
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
--
I
K
L
G
G
S
S
I
R
-------
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
-
S
--
R
-
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
-
57
PsiBlast_CBE
72.57
45%
-3
- C8 -
1NNJ
5
FPG_LACLC
A:
[2-271]
--
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
-----
I
S
I
E
A
T
Y
P
R
-
M
V
L
T
G
F
E
--
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
-
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
-
Q
L
I
Y
A
D
V
R
K
F
G
T
W
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
--
I
K
L
G
G
S
S
I
--------
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
-
S
--
R
-
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
-
52
PsiBlast_CBE
72.08
45%
4
- C8 -
2XZF
4
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
-----
I
S
I
E
A
T
Y
P
R
-
M
V
L
T
G
F
E
--
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
-
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
-
Q
L
I
Y
A
D
V
R
K
F
G
T
W
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
--
I
K
L
G
G
S
---------
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
-
S
--
R
-
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
-
50
PsiBlast_CBE
71.46
45%
5
- C8 -
3C58
4
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
-----
I
S
I
E
A
T
Y
P
R
-
M
V
L
T
G
F
E
--
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
-
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
-
Q
L
I
Y
A
D
V
R
K
F
G
T
W
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
--
I
K
L
G
G
S
S
I
R
------
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
-
S
--
R
-
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
-
49
PsiBlast_CBE
71.43
45%
4
- C8 -
4PDG
4
FPG_LACLC
A:
[1-271]
-
P
E
L
P
E
V
E
T
V
R
R
E
L
E
K
R
I
V
G
Q
K
I
-----
I
S
I
E
A
T
Y
P
R
-
M
V
L
T
G
F
E
--
Q
L
K
K
E
L
T
G
K
T
I
Q
G
I
S
R
R
G
K
Y
L
I
F
E
I
G
D
-------
D
-
F
R
L
I
S
H
L
R
M
E
G
K
Y
R
L
A
T
L
D
A
P
R
E
K
H
D
H
L
T
M
K
F
A
D
G
-
Q
L
I
Y
A
D
V
R
K
F
G
T
W
E
L
I
S
T
D
Q
V
L
P
Y
F
L
K
K
K
I
G
P
E
P
T
Y
E
D
F
D
E
K
L
F
R
E
K
L
R
K
S
T
K
K
I
K
P
Y
L
L
E
Q
T
L
V
A
G
L
G
N
I
Y
V
D
E
V
L
W
L
A
K
I
H
P
E
K
E
T
N
Q
L
I
E
S
S
I
H
L
L
H
D
S
I
I
E
I
L
Q
K
A
--
I
K
L
G
G
S
---------
S
A
L
G
S
T
G
K
M
Q
N
E
L
Q
V
Y
G
K
T
G
E
K
C
-
S
--
R
-
C
G
A
E
I
Q
K
I
K
V
A
G
R
G
T
H
F
C
P
V
C
Q
Q
K
-
59
PsiBlast_CBE
67.24
39%
38
- C8 -
1K82
4
FPG_ECOLI
D:
[1-267]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
G
A
T
I
LHAVV
R
N
G
R
L
R
W
P
V
--------
S
E
E
I
Y
R
-
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
L
-
P
-------
E
-
G
W
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
K
--
E
L
E
G
H
N
V
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
--
I
E
Q
G
G
T
T
L
K
-----------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
-
R
--
V
-
C
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
---
62
PsiBlast_CBE
66.10
39%
35
- C8 -
1K82
4
FPG_ECOLI
A:
[1-267]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
G
A
T
I
L
H
A
V
V
R
N
G
R
L
R
W
P
V
--------
S
E
E
I
Y
R
-
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
L
-
P
-------
E
-
G
W
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
K
--
E
L
E
G
H
N
V
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
--
I
E
Q
G
G
T
T
L
K
-----------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
-
R
--
V
-
C
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
---
61
PsiBlast_CBE
65.98
39%
37
- C8 -
1K82
4
FPG_ECOLI
B:
[1-267]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
G
A
T
I
LHAVV
R
N
G
R
L
R
W
P
V
--------
S
E
E
I
Y
R
-
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
L
-
P
-------
E
-
G
W
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
K
--
E
L
E
G
H
N
V
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
--
I
E
Q
G
G
T
T
L
K
-----------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
-
R
--
V
-
C
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
---
60
PsiBlast_CBE
64.36
39%
36
- C8 -
1K82
4
FPG_ECOLI
C:
[1-267]
-
P
E
L
P
E
V
E
T
S
R
R
G
I
E
P
H
L
V
G
A
T
I
LHAVV
R
N
G
R
L
R
W
P
V
--------
S
E
E
I
Y
R
-
L
S
D
Q
P
V
L
S
V
Q
R
R
A
K
Y
L
L
L
E
L
-
P
-------
E
-
G
W
I
I
I
H
L
G
M
S
G
S
L
R
I
L
P
E
E
L
P
P
E
K
H
D
H
V
D
L
V
M
S
N
G
K
V
L
R
Y
T
D
P
R
R
F
G
A
W
L
W
T
K
--
E
L
E
G
H
N
V
L
T
H
L
G
P
E
P
L
S
D
D
F
N
G
E
Y
L
H
Q
K
C
A
K
K
K
T
A
I
K
P
W
L
M
D
N
K
L
V
V
G
V
G
N
I
Y
A
S
E
S
L
F
A
A
G
I
H
P
D
R
L
A
S
S
L
S
L
A
E
C
E
L
L
A
R
V
I
K
A
V
L
L
R
S
--
I
E
Q
G
G
T
T
L
K
-----------
P
G
Y
F
A
Q
E
L
Q
V
Y
G
R
K
G
E
P
C
-
R
--
V
-
C
G
T
P
I
V
A
T
K
H
A
Q
R
A
T
F
Y
C
R
Q
C
Q
---
73
HHSearch
58.50
32%
39
- C8 -
3TWL
1
FPG_ARATH
A:
[2-279]
-
P
E
L
P
E
V
E
A
A
R
R
A
I
E
E
N
C
L
G
K
K
I
-----
K
R
V
I
I
A
D
D
N
K
V
I
H
G
I
-
S
P
S
D
F
Q
T
S
I
L
G
K
T
I
I
S
A
R
R
K
G
K
N
L
W
L
E
L
-
D
-------
S
P
P
F
P
S
F
Q
F
G
M
A
G
A
I
Y
I
K
----
W
P
S
K
Y
S
K
F
F
V
E
L
D
D
G
L
E
L
S
F
T
D
K
R
R
F
A
K
V
R
L
L
A
N
P
T
--
S
V
S
P
I
S
E
L
G
P
D
A
L
L
E
P
M
T
V
D
E
F
A
E
S
L
A
K
K
K
I
T
I
K
P
L
L
L
D
Q
G
Y
I
S
G
I
G
N
W
I
A
D
E
V
L
Y
Q
A
R
I
H
P
L
Q
T
A
S
S
L
S
K
E
Q
C
E
A
L
H
T
S
I
K
E
V
I
E
K
A
--
V
E
V
D
A
D
S
--------------
S
Q
F
P
S
N
W
I
F
H
N
R
E
K
K
P
G
-
K
AF
V
-
D
G
K
K
I
D
F
I
T
A
------
Y
V
P
E
L
Q
K
L
Y
67
PsiBlast_CBE
56.10
31%
11
- C8 -
3TWL
1
FPG_ARATH
A:
[2-276]
-
P
E
L
P
E
V
E
A
A
R
R
A
I
E
E
N
C
L
G
K
K
I
-----
K
R
V
I
I
A
D
D
N
-
K
V
I
H
G
I
S
P
S
D
F
Q
T
S
I
L
G
K
T
I
I
S
A
R
R
K
G
K
N
L
W
L
E
L
-
D
SPP
F
P
S
F
Q
-
F
G
M
A
G
A
I
Y
I
K
----------
W
P
S
K
Y
S
K
F
F
V
E
L
D
D
G
L
E
L
S
F
T
D
K
R
R
F
A
K
V
R
L
L
--
A
N
P
T
S
V
S
P
I
S
E
L
G
P
D
A
L
L
E
P
M
T
V
D
E
F
A
E
S
L
A
K
K
K
I
T
I
K
P
L
L
L
D
Q
G
Y
I
S
G
I
G
N
W
I
A
D
E
V
L
Y
Q
A
R
I
H
P
L
Q
T
A
S
S
L
S
K
E
Q
C
E
A
L
H
T
S
I
K
E
V
I
E
K
A
V
E
V
D
A
D
S
S
Q
F
P
S
NWI
F
H
N
R
E
K
K
P
G
----
K
A
F
V
D
G
K
K
--------------
I
D
F
I
T
A
------
Y
V
P
E
L
Q
---