@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu30190: (2016-07-19 )
MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTGYEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTPRTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKEWAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKDKLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECLRYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNPHLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPVTFE
Atome Classification :
(55 SA)
.........10........20........30....-....----40........50......-.---------.60....-....70---........80........90........100.......110.......120...--.-..-.130.......140.......150.......160.......170.......180.....-..190.......200.......210--....--..--.220.......230.......240.......250.......260.......270.......280..-.--..--...290.......300.......310.......320.......330.......340.......350.......360.......370---.----..--.--....380.......390...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTIASSTA
S
S
E
F
LK
N
P
Y
S
F
Y
D
T
L
R
A
VHPIYKG
S
F
L-KYP
G
----
W
Y
V
T
G
Y
E
E
T
A
A
I
L
KDA
R
F
-
K
---------
V
RTPLPE-SST
K
Y
Q
---
D
L
S
H
V
Q
N
Q
M
M
L
FQNQP
D
H
R
R
L
R
T
L
ASGAFTPRTTESYQ
P
Y
I
I
E
T
V
H
H
L
L
D
Q
VQG--
K
-
K
K
-
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
IIGVP
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
RSRKALTEGN
I
M
A
V
Q
-
A
M
A
Y
F
K
E
L
I
Q
K
R
KRH
P
Q
Q
D
M
I
S
M
L
L
--KGRE--KD--KL
T
E
E
EAAS
T
C
I
L
L
A
IAGH
E
T
T
V
N
L
I
S
N
S
V
L
C
L
LQH
P
E
Q
L
L
K
LRENPD
L
I
G
T
A
V
E
E
C
L
RYESP-
T
Q
-
M
--
T
A
--
R
VASEDI
D
I
C
G
V
T
IRQG
E
Q
V
Y
L
L
L
GAANRDPSIFTNP
D
V
F
DITRSPNPHLSFGHGH
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
Q
RMPSLNL----A----D
F
--
E
--
W
R
YRPLF
G
F
R
A
L
E
ELPVTFE
21
PsiBlast_CBE
99.47
100%
-128
- C5 -
3EJE
3
BIOI_BACSU
H:
[6-394]
------
T
A
S
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
G
S
F
L
-
K
Y
P
G
----
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
-
K
---------
V
R
T
P
L
P
E
-
S
S
T
K
Y
Q
---
D
L
S
H
V
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
--
K
-
K
K
-
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
A
L
T
E
G
N
I
M
A
V
Q
-
A
M
A
Y
F
K
E
L
I
Q
K
R
K
R
H
P
Q
Q
D
M
I
S
M
L
L
--
K
-----
K
D
--
K
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
-
T
Q
-
M
--
T
A
--
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
Q
R
M
P
S
L
N
L
----
A
-----------
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
E
23
PsiBlast_CBE
98.72
100%
-128
- C5 -
3EJE
3
BIOI_BACSU
D:
[6-394]
------
T
A
S
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
G
S
F
L
-
K
Y
P
G
----
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
-
K
---------
V
R
T
P
L
P
E
-
S
S
T
K
Y
Q
---
D
L
S
H
V
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
--
K
-
K
K
-
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
A
L
T
E
G
N
I
M
A
V
Q
-
A
M
A
Y
F
K
E
L
I
Q
K
R
K
R
H
P
Q
Q
D
M
I
S
M
L
L
--
K
G
R
-------
K
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
-
T
Q
-
M
--
T
A
--
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
Q
R
M
P
S
L
N
L
----
A
----
D
F
-----
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
E
24
PsiBlast_CBE
98.52
100%
-128
- C5 -
3EJD
3
BIOI_BACSU
H:
[7-393]
-------
A
S
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
G
S
F
L
-
K
Y
P
G
----
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
-
K
---------
V
R
T
P
L
P
E
-
S
S
T
K
Y
Q
---
D
L
S
H
V
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
--
K
-
K
K
-
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
A
L
T
E
G
N
I
M
A
V
Q
-
A
M
A
Y
F
K
E
L
I
Q
K
R
K
R
H
P
Q
Q
D
M
I
S
M
L
L
--
K
G
-----
D
--
K
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
-
T
Q
-
M
--
T
A
--
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
Q
R
M
P
S
L
N
L
----
A
----
D
------
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
-
26
PsiBlast_CBE
98.35
100%
-124
- C5 -
3EJD
3
BIOI_BACSU
D:
[6-394]
------
T
A
S
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
G
S
F
L
-
K
Y
P
G
----
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
-
K
---------
V
R
T
P
L
P
E
-
S
S
T
K
Y
Q
---
D
L
S
H
V
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
--
K
-
K
K
-
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
A
L
T
E
G
N
I
M
A
V
Q
-
A
M
A
Y
F
K
E
L
I
Q
K
R
K
R
H
P
Q
Q
D
M
I
S
M
L
L
--
K
G
R
E
--
K
----
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
-
T
Q
-
M
--
T
A
--
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
Q
R
M
P
S
L
N
L
----
A
----
D
------
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
E
2
PsiBlast_PDB
98.30
100%
-126
- C5 -
3EJD
4
BIOI_BACSU
B:
[9-394]
---------
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
G
S
F
L
-
K
Y
P
G
----
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
-
K
---------
V
R
T
P
L
P
E
-
S
S
T
K
Y
Q
---
D
L
S
H
V
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
--
K
-
K
K
-
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
A
L
T
E
G
N
I
M
A
V
Q
-
A
M
A
Y
F
K
E
L
I
Q
K
R
K
R
H
P
Q
Q
D
M
I
S
M
L
L
--
K
G
-----
D
--
K
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
-
T
Q
-
M
--
T
A
--
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
Q
R
M
P
S
L
N
L
----
A
----
D
---
E
--
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
E
22
PsiBlast_CBE
98.27
100%
-127
- C5 -
3EJE
2
BIOI_BACSU
F:
[9-394]
---------
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
G
S
F
L
-
K
Y
P
G
----
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
-
K
---------
V
R
T
P
L
P
E
-
S
S
T
K
Y
Q
---
D
L
S
H
V
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
--
K
-
K
K
-
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
A
L
T
E
G
N
I
M
A
V
Q
-
A
M
A
Y
F
K
E
L
I
Q
K
R
K
R
H
P
Q
Q
D
M
I
S
M
L
L
--
K
---------
K
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
-
T
Q
-
M
--
T
A
--
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
Q
R
M
P
S
L
N
L
----
A
----
D
---
E
--
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
E
29
PsiBlast_CBE
98.00
100%
-123
- C5 -
3EJB
3
BIOI_BACSU
D:
[6-394]
------
T
A
S
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
G
S
F
L
-
K
Y
P
G
----
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
-
K
---------
V
R
T
P
L
P
E
-
S
S
T
K
Y
Q
---
D
L
S
H
V
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
--
K
-
K
K
-
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
A
L
T
E
G
N
I
M
A
V
Q
-
A
M
A
Y
F
K
E
L
I
Q
K
R
K
R
H
P
Q
Q
D
M
I
S
M
L
L
--
K
G
R
E
--
K
D
--
K
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
-
T
Q
-
M
--
T
A
--
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
Q
R
M
P
S
L
N
L
----
A
-----------
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
E
27
PsiBlast_CBE
97.82
100%
-123
- C5 -
3EJB
3
BIOI_BACSU
H:
[6-393]
------
T
A
S
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
G
S
F
L
-
K
Y
P
G
----
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
-
K
---------
V
R
T
P
L
P
E
-
S
S
T
K
Y
Q
---
D
L
S
H
V
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
--
K
-
K
K
-
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
A
L
T
E
G
N
I
M
A
V
Q
-
A
M
A
Y
F
K
E
L
I
Q
K
R
K
R
H
P
Q
Q
D
M
I
S
M
L
L
--
K
G
R
E
--
K
D
--
K
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
-
T
Q
-
M
--
T
A
--
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
Q
R
M
P
S
L
N
L
----
A
----
D
---
E
--
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
-
1
PsiBlast_PDB
97.68
100%
-124
- C5 -
3EJB
4
BIOI_BACSU
B:
[9-394]
---------
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
G
S
F
L
-
K
Y
P
G
----
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
-
K
---------
V
R
T
P
L
P
E
-
S
S
T
K
Y
Q
---
D
L
S
H
V
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
--
K
-
K
K
-
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
A
L
T
E
G
N
I
M
A
V
Q
-
A
M
A
Y
F
K
E
L
I
Q
K
R
K
R
H
P
Q
Q
D
M
I
S
M
L
L
--
K
G
--------
K
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
-
T
Q
-
M
--
T
A
--
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
Q
R
M
P
S
L
N
L
----
A
--------
E
--
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
E
25
PsiBlast_CBE
97.02
100%
-124
- C5 -
3EJD
4
BIOI_BACSU
F:
[9-394]
---------
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
G
S
F
L
-
K
Y
P
G
----
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
-
K
---------
V
R
T
P
L
P
E
-
S
S
T
K
Y
Q
---
D
L
S
H
V
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
--
K
-
K
K
-
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
A
L
T
E
G
N
I
M
A
V
Q
-
A
M
A
Y
F
K
E
L
I
Q
K
R
K
R
H
P
Q
Q
D
M
I
S
M
L
L
--
K
G
R
----
D
--
K
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
-
T
Q
-
M
--
T
A
--
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
Q
R
M
P
S
L
N
L
----
A
-----------
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
E
3
PsiBlast_PDB
97.01
100%
-126
- C5 -
3EJE
3
BIOI_BACSU
B:
[9-394]
---------
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
G
S
F
L
-
K
Y
P
G
----
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
-
K
---------
V
R
T
P
L
P
E
-
S
S
T
K
Y
Q
---
D
L
S
H
V
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
--
K
-
K
K
-
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
A
L
T
E
G
N
I
M
A
V
Q
-
A
M
A
Y
F
K
E
L
I
Q
K
R
K
R
H
P
Q
Q
D
M
I
S
M
L
L
--
K
---------
K
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
-
T
Q
-
M
--
T
A
--
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
Q
R
M
P
S
L
N
L
----
A
-----------
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
E
28
PsiBlast_CBE
96.55
100%
-125
- C5 -
3EJB
4
BIOI_BACSU
F:
[10-394]
----------
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
G
S
F
L
-
K
Y
P
G
----
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
-
K
---------
V
R
T
P
L
P
E
-
S
S
T
K
Y
Q
---
D
L
S
H
V
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
--
K
-
K
K
-
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
S
R
K
A
L
T
E
G
N
I
M
A
V
Q
-
A
M
A
Y
F
K
E
L
I
Q
K
R
K
R
H
P
Q
Q
D
M
I
S
M
L
L
--
K
G
--------
K
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
-
T
Q
-
M
--
T
A
--
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
Q
R
M
P
S
L
N
L
----
A
-----------
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
E
119
HHSearch
88.24
97%
-67
- C5 -
3EJB
4
BIOI_BACSU
B:
[9-394]
---------
S
E
F
L
K
N
P
Y
S
F
Y
D
T
L
R
A
V
H
P
I
Y
K
G
S
F
L
-
K
Y
P
G
----
W
Y
V
T
G
Y
E
E
T
A
A
I
L
K
D
A
R
F
-
K
---------
V
R
T
P
L
P
E
-
S
S
T
K
Y
Q
---
D
L
S
H
V
Q
N
Q
M
M
L
F
Q
N
Q
P
D
H
R
R
L
R
T
L
A
S
G
A
F
T
P
R
T
T
E
S
Y
Q
P
Y
I
I
E
T
V
H
H
L
L
D
Q
V
Q
G
--
K
-
K
K
-
M
E
V
I
S
D
F
A
F
P
L
A
S
F
V
I
A
N
I
I
G
V
P
E
E
D
R
E
Q
L
K
E
W
A
A
S
L
I
Q
T
I
D
F
T
R
-
S
R
K
A
L
T
E
G
N
I
M
A
V
Q
A
M
A
Y
F
K
E
L
I
Q
K
R
K
R
H
P
Q
Q
D
M
I
S
M
L
L
--
K
G
--------
K
L
T
E
E
E
A
A
S
T
C
I
L
L
A
I
A
G
H
E
T
T
V
N
L
I
S
N
S
V
L
C
L
L
Q
H
P
E
Q
L
L
K
L
R
E
N
P
D
L
I
G
T
A
V
E
E
C
L
R
Y
E
S
P
-
T
Q
-
M
--
T
A
--
R
V
A
S
E
D
I
D
I
C
G
V
T
I
R
Q
G
E
Q
V
Y
L
L
L
G
A
A
N
R
D
P
S
I
F
T
N
P
D
V
F
D
I
T
R
S
P
N
P
H
L
S
F
G
H
G
H
H
V
C
L
G
S
S
L
A
R
L
E
A
Q
I
A
I
N
T
L
L
Q
R
M
P
S
L
N
L
----
A
--------
E
--
W
R
Y
R
P
L
F
G
F
R
A
L
E
E
L
P
V
T
F
E
121
HHSearch
63.64
33%
-40
- C5 -
3BUJ
1
?
A:
[8-394]
--------
D
A
D
V
R
R
D
P
Y
P
S
Y
H
W
L
L
R
H
D
P
V
H
R
---
G
-
A
H
R
V
----
W
Y
V
S
R
F
A
D
V
R
A
V
L
G
D
E
R
--
F
---------
A
R
T
G
I
R
R
-
F
W
T
D
L
V
GPG
L
L
A
E
I
V
G
D
I
I
L
F
Q
D
E
P
D
H
G
R
L
R
G
V
V
G
P
A
F
S
P
S
A
L
R
R
L
E
P
V
I
A
G
T
V
D
D
L
L
R
P
A
L
A
--
R
-
G
A
-
M
D
V
V
D
E
L
A
Y
P
L
A
L
R
A
V
L
G
L
L
G
L
P
A
A
D
W
G
A
V
G
R
W
S
R
D
V
G
R
T
L
D
R
G
-
A
S
A
E
D
M
R
R
G
H
A
A
I
A
E
F
A
D
Y
V
E
R
A
L
A
R
R
R
R
E
G
G
E
D
L
L
A
L
M
L
--
D
A
H
D
--
R
G
--
L
M
S
R
N
E
I
V
S
T
V
V
T
F
I
F
T
G
H
E
T
V
A
S
Q
V
G
N
A
V
L
S
L
L
A
H
P
D
Q
L
D
L
L
R
R
R
P
D
L
L
A
Q
A
V
E
E
C
L
R
Y
D
P
S
-
V
Q
-
S
--
N
T
--
R
Q
L
D
V
D
V
E
L
R
G
R
R
L
R
R
D
D
V
V
V
V
L
A
G
A
A
N
R
D
P
R
R
Y
D
R
P
D
D
F
D
I
E
R
D
P
V
P
S
M
S
F
G
A
G
M
R
Y
C
L
G
S
Y
L
A
R
T
Q
L
R
A
A
V
A
A
L
A
R
L
P
-
G
L
R
L
----
G
----
C
A
--
S
DA
L
A
Y
Q
P
R
T
M
F
R
G
L
A
S
L
P
I
A
F
T
132
HHSearch
63.24
38%
-28
- C5 -
3A4G
2
CPVDH_PSEAH
A:
[15-399]
--------
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
A
L
P
-
D
G
P
V
----
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
S
K
---------
D
W
R
H
T
L
--
P
E
D
Q
R
A
---
D
M
P
A
T
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
--
D
-
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
D
D
-----
S
P
A
D
---
D
K
N
A
A
M
G
K
L
H
G
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
--
A
V
S
D
ED
G
D
--
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
-
V
S
-
Q
A-
P
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
----
A
----
V
G
--
L
DE
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
40
PsiBlast_CBE
62.92
37%
-9
- C5 -
3A4Z
4
CPVDH_PSEAH
C:
[15-398]
--------
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
A
L
P
-
D
G
P
V
----
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
-
S
KD-------
W
R
H
R
L
P
E
-
D
--
Q
R
A
---
D
M
P
A
T
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
--
D
-
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
D
--
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
------
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
AV
S
D
M
D
--
G
D
--
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
--
P
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
----
A
----
V
G
LD
E
--
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
-
31
PsiBlast_CBE
62.30
37%
-5
- C5 -
3A51
6
CPVDH_PSEAH
D:
[15-398]
--------
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
A
L
P
-
D
G
P
V
----
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
-
S
KD-------
W
R
H
R
L
P
E
-
D
--
Q
R
A
---
D
M
P
A
T
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
--
D
-
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
D
--
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
------
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
AV
S
D
M
D
--
G
D
--
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
--
P
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
----
A
----
V
G
LD
E
--
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
-
8
PsiBlast_PDB
62.18
37%
-5
- C5 -
3A50
8
CPVDH_PSEAH
A:
[15-398]
--------
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
A
L
P
-
D
G
P
V
----
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
-
S
KD-------
W
R
H
R
L
P
E
-
D
--
Q
R
A
---
D
M
P
A
T
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
--
D
-
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
D
--
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
------
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
M
D
--
G
D
--
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
--
P
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
----
A
----
V
G
LD
E
--
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
-
36
PsiBlast_CBE
61.96
37%
-9
- C5 -
3A50
5
CPVDH_PSEAH
C:
[15-398]
--------
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
A
L
P
-
D
G
P
V
----
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
-
S
KD-------
W
R
H
R
L
P
E
-
D
--
Q
R
A
---
D
M
P
A
T
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
--
D
-
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
D
--
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
------
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
AV
S
D
M
D
--
G
D
--
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
--
P
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
----
A
----
V
G
LD
E
--
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
-
30
PsiBlast_CBE
61.92
37%
-6
- C5 -
3A51
4
CPVDH_PSEAH
E:
[15-398]
--------
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
A
L
P
-
D
G
P
V
----
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
-
S
KD-------
W
R
H
R
L
P
E
-
D
--
Q
R
A
---
D
M
P
A
T
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
--
D
-
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
D
--
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
------
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
AV
S
D
M
D
--
G
D
--
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
--
P
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
----
A
----
V
G
LD
E
--
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
-
4
PsiBlast_PDB
61.35
37%
-7
- C5 -
3A4G
2
CPVDH_PSEAH
A:
[15-398]
--------
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
A
L
P
-
D
G
P
V
----
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
-
S
KD-------
W
R
H
T
L
P
E
-
D
--
Q
R
A
---
D
M
P
A
T
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
--
D
-
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
D
--
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
------
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
E
D
--
G
D
--
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
--
P
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
----
A
----
V
G
LD
E
--
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
-
5
PsiBlast_PDB
61.17
37%
-6
- C5 -
3A4H
2
CPVDH_PSEAH
A:
[15-398]
--------
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
A
L
P
-
D
G
P
V
----
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
-
S
KD-------
W
R
H
T
L
P
E
-
D
--
Q
R
A
---
D
M
P
A
T
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
--
D
-
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
D
--
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
------
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
E
D
--
G
D
--
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
--
P
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
----
A
----
V
G
LD
E
--
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
-
19
PsiBlast_PDB
61.03
35%
10
- C5 -
2CD8
2
PIKC_STRVZ
A:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
6
PsiBlast_PDB
61.00
37%
-11
- C5 -
3VRM
2
CPVDH_PSEAH
A:
[15-398]
--------
S
G
T
F
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
V
R
K
L
A
L
P
-
D
G
P
V
----
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L
-
S
KD-------
W
R
H
T
L
P
E
-
D
--
Q
R
A
---
D
M
P
A
T
P
T
P
M
M
I
L
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
A
V
R
R
M
N
E
L
E
P
R
I
T
E
I
A
D
G
L
L
A
G
L
P
T
--
D
-
G
P
-
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
E
D
R
D
D
F
S
A
W
S
S
V
L
V
D
--
D
S
P
A
D
D
K
N
A
A
M
G
K
L
H
G
------
Y
L
S
D
L
L
E
R
K
R
T
E
P
D
D
A
L
L
S
S
L
L
A
V
S
D
E
D
--
G
D
--
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
I
S
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
--
P
I
--
R
F
T
A
E
D
V
T
Y
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
G
G
V
F
F
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
----
A
----
V
G
LD
E
--
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
-
75
PsiBlast_CBE
60.45
35%
11
- C5 -
2VZM
2
PIKC_STRVZ
A:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
15
PsiBlast_PDB
60.19
35%
10
- C5 -
2BVJ
3
PIKC_STRVZ
A:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
74
PsiBlast_CBE
59.92
35%
11
- C5 -
2VZM
2
PIKC_STRVZ
B:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
45
PsiBlast_CBE
59.84
35%
14
- C5 -
4B7D
4
PIKC_STRVZ
B:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
GDEV
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
16
PsiBlast_PDB
59.72
35%
5
- C5 -
2C6H
6
PIKC_STRVZ
A:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
GDE
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
14
PsiBlast_PDB
59.70
35%
7
- C5 -
2WI9
2
PIKC_STRVZ
A:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
76
PsiBlast_CBE
59.61
35%
9
- C5 -
2VZ7
2
PIKC_STRVZ
B:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
13
PsiBlast_PDB
59.55
35%
10
- C5 -
2WHW
2
PIKC_STRVZ
A:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
72
PsiBlast_CBE
59.41
35%
8
- C5 -
3ZK5
2
PIKC_STRVZ
B:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
17
PsiBlast_PDB
59.39
35%
11
- C5 -
2C7X
2
PIKC_STRVZ
A:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
51
PsiBlast_CBE
59.30
35%
12
- C5 -
4UMZ
2
PIKC_STRVZ
A:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
71
PsiBlast_CBE
59.24
35%
9
- C5 -
3ZPI
13
PIKC_STRVZ
A:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
70
PsiBlast_CBE
59.22
35%
10
- C5 -
3ZPI
6
PIKC_STRVZ
B:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
69
PsiBlast_CBE
59.19
35%
9
- C5 -
4B7S
14
PIKC_STRVZ
A:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
48
PsiBlast_CBE
59.19
35%
7
- C5 -
2C6H
3
PIKC_STRVZ
B:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
GDEV
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
46
PsiBlast_CBE
59.08
35%
8
- C5 -
2CD8
2
PIKC_STRVZ
B:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
GDEV
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
44
PsiBlast_CBE
59.06
35%
7
- C5 -
2WHW
4
PIKC_STRVZ
B:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
50
PsiBlast_CBE
59.03
35%
8
- C5 -
4UMZ
2
PIKC_STRVZ
B:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
43
PsiBlast_CBE
58.98
35%
8
- C5 -
2WI9
5
PIKC_STRVZ
B:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
78
PsiBlast_CBE
58.39
34%
7
- C5 -
1Z8Q
3
CPXJ_SACEN
A:
[2-403]
-
T
T
V
P
D
L
E
S
D
S
F
H
V
D
W
Y
R
T
Y
A
E
L
R
E
T
A
P
V
T
P
V
R
F
L
-
G
Q
D
A
----
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
-
S
SDPKKKYPG
V
E
V
E
F
P
A
-
Y
L
G
F
P
E
---
D
V
R
N
Y
F
A
T
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
G
D
--
S
-
G
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
-
V
M
D
P
E
R
A
E
Q
R
----
G
Q
A
A
R
E
-
V
V
N
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
--
R
V
Q
D
--
D
D
DG
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
T
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
-
P
E
-
T
--
T
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
L
----
G
IDAD
D
V
--
V
--
W
R
-
R
S
L
L
-
L
R
G
I
D
H
L
P
V
R
L
D
73
PsiBlast_CBE
58.28
35%
11
- C5 -
3ZK5
2
PIKC_STRVZ
A:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
12
PsiBlast_PDB
58.25
38%
-24
- C5 -
3WVS
8
?
A:
[48-386]
--------------------------------------
P
A
----
W
L
A
T
R
Y
E
D
A
R
L
V
L
G
D
A
R
F
-
S
----------
R
A
L
S
E
E
-
H
D
P
P
R
A
---
R
K
F
N
A
Q
A
K
S
M
F
N
M
D
A
P
D
H
T
R
L
R
R
L
I
S
K
A
F
T
I
R
R
V
E
E
L
R
P
K
V
H
D
L
A
H
R
L
I
D
D
M
L
A
--
K
-
G
E
P
A
D
L
V
A
D
Y
A
L
P
I
P
T
T
V
I
C
E
L
L
G
V
P
F
E
D
R
E
K
F
G
R
W
T
D
A
I
L
S
T
S
T
L
N
P
E
-----
E
G
R
V
K
R
M
E
-
L
V
G
Y
I
G
G
I
I
A
A
R
R
A
Q
P
A
D
D
L
I
S
G
M
I
--
E
A
R
D
V-
Q
D
--
K
L
T
E
Q
E
L
L
D
H
C
I
G
L
L
I
A
G
H
E
T
T
A
S
Q
I
P
S
F
V
Y
A
L
L
D
Q
P
Q
H
W
K
R
L
L
D
D
P
E
L
I
P
S
A
V
E
E
L
F
R
F
V
P
L
-
G
S
-
G
--
S
A
A
P
R
Y
A
R
E
D
I
E
V
G
G
T
L
V
R
A
G
E
P
V
L
V
A
L
G
A
A
N
R
D
G
L
R
F
E
D
P
E
E
I
K
L
D
R
P
S
N
H
H
I
G
F
G
H
G
I
H
H
C
L
G
A
P
L
A
R
L
E
L
Q
E
A
L
R
A
L
L
E
R
L
P
T
L
K
V
----
A
G
---
D
I
--
A
--
W
K
------------------
68
PsiBlast_CBE
58.16
35%
9
- C5 -
4B7S
6
PIKC_STRVZ
B:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
49
PsiBlast_CBE
58.11
35%
11
- C5 -
2BVJ
3
PIKC_STRVZ
B:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
---------
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
20
PsiBlast_PDB
57.94
35%
8
- C5 -
4B7D
3
PIKC_STRVZ
A:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
80
PsiBlast_CBE
57.33
33%
8
- C5 -
1Z8O
3
CPXJ_SACEN
A:
[3-403]
--
T
V
P
D
L
E
S
D
S
F
H
V
D
W
Y
R
T
Y
A
E
L
R
E
T
A
P
V
T
P
V
R
F
L
-
G
Q
D
A
----
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
-
S
SDPKKKYPG
V
E
V
E
F
P
A
-
Y
L
G
F
P
E
---
D
V
R
N
Y
F
A
T
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
G
D
--
S
-
G
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
-
V
M
D
P
E
R
A
E
Q
R
----
G
Q
A
A
R
E
-
V
V
N
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
--
R
V
Q
D
--
D
D
DG
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
A
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
-
P
E
-
T
--
T
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
L
----
G
IDAD
D
V
--
V
--
W
R
-
R
S
L
L
-
L
R
G
I
D
H
L
P
V
R
L
D
77
PsiBlast_CBE
56.89
35%
12
- C5 -
2VZ7
2
PIKC_STRVZ
A:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
N
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
79
PsiBlast_CBE
56.76
33%
10
- C5 -
1Z8P
3
CPXJ_SACEN
A:
[2-403]
-
T
T
V
P
D
L
E
S
D
S
F
H
V
D
W
Y
R
T
Y
A
E
L
R
E
T
A
P
V
T
P
V
R
F
L
-
G
Q
D
A
----
W
L
V
T
G
Y
D
E
A
K
A
A
L
S
D
L
R
L
-
S
SDPKKKYPG
V
E
V
E
F
P
A
-
Y
L
G
F
P
E
---
D
V
R
N
Y
F
A
T
N
M
G
T
S
D
P
P
T
H
T
R
L
R
K
L
V
S
Q
E
F
T
V
R
R
V
E
A
M
R
P
R
V
E
Q
I
T
A
E
L
L
D
E
V
G
D
--
S
-
G
V
-
V
D
I
V
D
R
F
A
H
P
L
P
I
K
V
I
C
E
L
L
G
V
D
E
K
Y
R
G
E
F
G
R
W
S
S
E
I
L
-
V
M
D
P
E
R
A
E
Q
R
----
G
Q
A
A
R
E
-
V
V
N
F
I
L
D
L
V
E
R
R
R
T
E
P
G
D
D
L
L
S
A
L
I
--
R
V
Q
D
--
D
D
DG
R
L
S
A
D
E
L
T
S
I
A
L
V
L
L
L
A
G
F
E
S
S
V
S
L
I
G
I
G
T
Y
L
L
L
T
H
P
D
Q
L
A
L
V
R
R
D
P
S
A
L
P
N
A
V
E
E
I
L
R
Y
I
A
P
-
P
E
-
T
--
T
T
--
R
F
A
A
E
E
V
E
I
G
G
V
A
I
P
Q
Y
S
T
V
L
V
A
N
G
A
A
N
R
D
P
K
Q
F
P
D
P
H
R
F
D
V
T
R
D
T
R
G
H
L
S
F
G
Q
G
I
H
F
C
M
G
R
P
L
A
K
L
E
G
E
V
A
L
R
A
L
F
G
R
F
P
A
L
S
L
----
G
IDAD
D
V
--
V
--
W
R
-
R
S
L
L
-
L
R
G
I
D
H
L
P
V
R
L
D
18
PsiBlast_PDB
56.75
35%
7
- C5 -
2CA0
2
PIKC_STRVZ
A:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
G
D
E
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
47
PsiBlast_CBE
56.18
35%
11
- C5 -
2CA0
2
PIKC_STRVZ
B:
[41-425]
--------
G
Q
D
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
---
V
-
R
T
P
E
GDEV
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
-
S
-----------
K
D
W
R
N
-
S
T
T
P
L
T
---
E
A
E
A
A
L
N
H
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
M
L
A
AP
D
-
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
F
P
D
D
P
A
Q
A
Q
T
A
M
A
E
M
S
--------
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
--
R
T
S
D
--
E
D
GS
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
-
V
E
S
A
--
T
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
DVSP
G
----
E
L
--
V
--
W
Y
P
N
P
M
--
I
R
G
L
K
A
L
P
I
R
W
-
131
HHSearch
52.16
34%
4
- C5 -
3WVS
8
?
A:
[17-401]
-------
F
G
P
D
E
G
L
A
L
S
E
S
Y
T
R
A
R
D
T
D
G
L
I
R
V
K
L
P
Y
G
E
P
A
----
W
L
A
T
R
Y
E
D
A
R
L
V
L
G
D
A
R
--
F
---------
S
R
A
L
S
E
E
H
D
P
P
R
-
A
---
R
K
F
N
A
Q
A
K
S
M
F
N
M
D
A
P
D
H
T
R
L
R
R
L
I
S
K
A
F
T
I
R
R
V
E
E
L
R
P
K
V
H
D
L
A
H
R
L
I
D
D
M
L
A
--
K
G
E
P
-
A
D
L
V
A
D
Y
A
L
P
I
P
T
T
V
I
C
E
L
L
G
V
P
F
E
D
R
E
K
F
G
R
W
T
D
A
I
L
S
T
S
T
L
--
N
P
E
----
E
G
R
V
K
R
M
E
L
V
G
Y
I
G
G
I
I
A
A
R
R
A
Q
P
A
D
D
L
I
S
G
M
I
--
E
A
R
D
V-
Q
D
--
K
L
T
E
Q
E
L
L
D
H
C
I
G
L
L
I
A
G
H
E
T
T
A
S
Q
I
P
S
F
V
Y
A
L
L
D
Q
P
Q
H
W
K
R
L
L
D
D
P
E
L
I
P
S
A
V
E
E
L
F
R
F
V
P
L
-
G
S
-
G
SA
A
P
--
R
Y
A
R
E
D
I
E
V
G
G
T
L
V
R
A
G
E
P
V
L
V
A
L
G
A
A
N
R
D
G
L
R
F
E
D
P
E
E
I
K
L
D
R
P
S
N
H
H
I
G
F
G
H
G
I
H
H
C
L
G
A
P
L
A
R
L
E
L
Q
E
A
L
R
A
L
L
E
R
L
-
P
T
L
K
----
V
----
A
G
--
D
--
I
A
W
K
S
E
M
M
V
R
G
P
R
S
M
P
V
G
W
-