@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu38260: (2016-08-03 )
MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTAAKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSLTQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKSKKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFVNKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFRKIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTGKQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTIGSALYACPGGCKKGEYIAQRLLES
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80...---------..-.-------..90........100.......110.--....-..120.....-.---.130-........140.......150........160.......170.......180.......190.......200.......210.......220---...----..----..230--.........240.......250.......--260.--...--....270.......280.......290.......300.....-..310.---.....--------.----------320------...------......-----330-.---.-.----......340.......350.......360.......370.......380---..-.......390...-....400..-.....410....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSDEQK
K
P
E
Q
I
H
R
R
D
I
L
K
W
G
AMAG
A
A
V
A
IGASGLG
G
L
A
P
L
V
Q
T
AAKPSKKDE
K
E
E
EQIVPFYGKHQAG
I
T
T
A
H
Q
T
Y
V
Y
F
A
A
L
D
V
---------TA-K-------D
K
S
D
I
I
T
L
F
R
N
W
T
S
L
T
Q
M
L
TSGKKM
S
--
A
E
Q
R-NQYLPPQDTG-E---SAD--LSPS
N
L
T
V
T
FGFGPGFFEK-DGKDRFGLKSKKPKHLAALPAMPNDNLDEKQGGG
D
I
C
I
Q
V
CADD
E
Q
V
A
F
H
A
L
R
N
L
L
N
QAVG
T
C
E
V
R
F
V
N
K
G
F---LSG----GK----NGE----TPRNLFGFKDGTGNQSTK
D
D
T
L
M
N
S
I
V
W
I
--QS-G--EPD--WMTG
G
T
Y
M
A
F
R
K
I
K
M
F
L
E
V
WDRSSLKD
Q
E
D
T
FGRRKSSGAPF-GQKKET---DP
V
K
L
--------N----------Q--------IPS------NS
H
V
S
L
-----
A
---
K
---
S
-
T
----
G
K
Q
I
L
R
R
A
F
S
YTEGLDPKTGY
M
D
A
G
L
L
F
I
S
F
QKNPDN
Q
F
I
P
M
L
K
A
L
S
-----
A
K
-
D
A
L
N
E
Y
T
Q
T
I
G
S
A
-
L
Y
ACPGGCK-
K
G
E
Y
I
A
Q
R
L
LES
23
PsiBlast_CBE
74.52
37%
4
- C6 -
2Y4D
13
EFEB_ECOLI
B:
[28-401]
--------------------------------------------------
D
A
R
N
E
K
Q
--
P
F
Y
G
E
H
Q
A
G
I
L
T
P
Q
Q
A
A
M
M
L
V
A
F
D
V
---------
L
A
-
S
-------
D
K
A
D
L
E
R
L
F
R
L
L
T
Q
R
F
A
F
L
T
Q
G
G
A
-
A
--
P
E
T
P
-
N
P
R
L
P
P
L
D
S
G
I
L
---
G
G
Y
--
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
-----
E
R
F
G
L
A
P
Q
M
P
K
K
L
Q
K
M
T
R
F
P
N
D
S
L
D
A
A
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
---
I
S
D
HAAR
S
K
----
G
K
E
----
T
P
I
N
L
L
G
F
K
D
G
T
A
N
P
D
S
Q
N
D
K
L
M
Q
K
V
V
W
V
--
T
A
-
D
QQ
E
P
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
P
L
K
E
Q
Q
T
I
F
G
R
D
K
Q
T
G
A
P
L
-
G
M
Q
H
E
H
---
D
V
P
D
Y
--------
A
----------
S
--------
D
P
E
GKVIAL
D
S
H
I
R
L
ANP----------
S
-
E
----
S
S
L
M
L
R
R
G
Y
S
Y
S
L
G
V
T
-
N
S
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
H
D
L
E
K
G
F
L
T
V
Q
K
R
L
N
-----
G
--
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
D
-
A
N
D
Y
F
G
S
A
L
L
--
1
PsiBlast_PDB
74.48
44%
36
- C6 -
4GRC
2
?
A:
[78-428]
----------------------------------------------------------
V
P
F
H
G
A
H
Q
A
G
I
A
T
P
V
Q
D
R
L
H
F
A
A
F
D
V
---------
T
T
-
E
-------
D
R
A
A
F
V
A
L
L
K
E
W
T
A
A
A
R
R
L
T
A
G
H
A
V
G
EG
A
Y
G
G
-
L
P
E
A
P
P
D
D
T
G
-
E
---
A
L
G
--
L
K
P
S
R
L
T
L
T
I
G
F
G
P
S
L
F
T
------
R
F
G
L
A
D
L
R
P
E
A
L
A
D
L
P
K
F
P
G
D
N
L
D
R
A
R
S
G
G
D
L
C
V
Q
A
C
A
D
D
P
Q
V
A
V
H
A
I
R
N
L
A
R
I
G
F
G
K
V
V
V
R
W
S
Q
L
G
F
GKT
S
S
T
----
T
P
----
D
E
Q
----
T
P
R
N
L
L
G
F
K
D
G
T
R
N
I
A
G
T
E
K
D
R
L
D
R
F
V
W
A
AE
K
D
-
G
--
T
P
---
W
M
T
G
G
S
Y
L
V
A
R
R
I
R
M
H
I
E
T
W
D
R
A
S
L
Q
E
Q
E
D
V
F
G
R
D
K
G
E
G
A
P
V
-
G
K
A
K
E
R
---
D
E
P
F
L
--------
K
----------
A
--------
M
K
P
------
D
A
H
V
R
L
-----
A
---
H
PDS
N
-
G
----
G
A
T
L
L
R
R
G
Y
S
F
T
D
G
T
D
------
D
A
G
L
F
F
L
A
Y
Q
R
D
I
R
T
G
F
V
P
V
Q
R
N
L
------
A
T
-
D
A
L
N
E
Y
I
Q
H
V
G
S
A
-
V
F
A
V
P
P
G
V
R
-
D
A
D
---------
3
PsiBlast_PDB
74.38
37%
1
- C6 -
2Y4D
14
EFEB_ECOLI
A:
[28-401]
--------------------------------------------------
D
A
R
N
E
K
Q
--
P
F
Y
G
E
H
Q
A
G
I
L
T
P
Q
Q
A
A
M
M
L
V
A
F
D
V
---------
L
A
-
S
-------
D
K
A
D
L
E
R
L
F
R
L
L
T
Q
R
F
A
F
L
T
Q
G
G
A
-
A
--
P
E
T
P
-
N
P
R
L
P
P
L
D
S
G
I
L
---
G
G
Y
--
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
-----
E
R
F
G
L
A
P
Q
M
P
K
K
L
Q
K
M
T
R
F
P
N
D
S
L
D
A
A
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
---
I
S
D
H
A
A
R
S
K
----
G
K
E
----
T
P
I
N
L
L
G
F
K
D
G
T
A
N
P
D
S
Q
N
D
K
L
M
Q
K
V
V
W
V
--
T
A
-
D
QQ
E
P
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
P
L
K
E
Q
Q
T
I
F
G
R
D
K
Q
T
G
A
P
L
-
G
M
Q
H
E
H
---
D
V
P
D
Y
--------
A
----------
S
--------
D
P
E
GKVIAL
D
S
H
I
R
L
A
NP----------
S
-
E
----
S
S
L
M
L
R
R
G
Y
S
Y
S
L
G
V
T
-
N
S
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
H
D
L
E
K
G
F
L
T
V
Q
K
R
L
N
-----
G
--
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
D
-
A
N
D
Y
F
G
S
A
L
L
--
5
PsiBlast_PDB
73.72
37%
11
- C6 -
3O72
2
EFEB_ECO57
A:
[13-386]
-----------------------------------------------
V
A
R
N
E
K
Q
-----
P
F
Y
G
E
H
Q
A
G
I
L
T
P
Q
Q
A
A
M
M
L
V
A
F
D
V
---------
L
A
-
S
-------
D
K
A
D
L
E
R
L
F
R
L
L
T
Q
R
F
A
F
L
T
Q
G
G
-
A
A
--
P
E
T
P
-
N
P
R
L
P
P
L
D
S
G
I
L
---
G
G
Y
--
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
-----
E
R
F
G
L
A
P
Q
M
P
K
K
L
Q
K
M
T
R
F
P
N
D
S
L
D
A
A
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
---
I
S
D
H
A
A
R
S
K
----
G
K
E
----
T
P
I
N
L
L
G
F
K
D
G
T
A
N
P
D
S
Q
N
D
K
L
M
Q
K
V
V
W
V
--
T
A
-
D
QQ
E
P
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
P
L
K
E
Q
Q
T
I
F
G
R
D
K
Q
T
G
A
P
L
-
G
M
Q
H
E
H
---
D
V
P
D
Y
--------
A
----------
S
--------
D
P
E
GKGIAL
D
S
H
I
R
L
A
NPRT
A
---
E
---
S
-
E
----
S
S
L
M
L
R
R
G
Y
S
Y
S
L
G
V
T
-
N
S
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
H
D
L
E
K
G
F
L
T
V
Q
K
R
L
N
-----
G
--
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
D
-
A
N
D
Y
L
G
S
A
L
L
--
2
PsiBlast_PDB
72.64
37%
16
- C6 -
2Y4F
10
EFEB_ECOLI
A:
[9-390]
------------------------------------------
S
A
P
G
T
L
S
P
D
A
R
N
E
K
Q
--
P
F
Y
G
E
H
Q
A
G
I
L
T
P
Q
Q
A
A
M
M
L
V
A
F
D
V
---------
L
A
-
S
-------
D
K
A
D
L
E
R
L
F
R
L
L
T
Q
R
F
A
F
L
T
Q
G
G
A
-
A
--
P
E
T
P
-
N
P
R
L
P
P
L
D
S
G
I
L
---
G
G
Y
--
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
-----
E
R
F
G
L
A
P
Q
M
P
K
K
L
Q
K
M
T
R
F
P
N
D
S
L
D
A
A
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
---
I
S
D
H
A
A
R
S
K
----
G
K
E
----
T
P
I
N
L
L
G
F
K
D
G
T
A
N
P
D
S
Q
N
D
K
L
M
Q
K
V
V
W
V
--
T
A
-
D
QQ
E
P
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
P
L
K
E
Q
Q
T
I
F
G
R
D
K
Q
T
G
A
P
L
-
G
M
Q
H
E
H
---
D
V
P
D
Y
--------
A
----------
S
--------
D
P
E
GKVIAL
D
S
H
I
R
L
A
NPRT
A
---
E
---
S
-
E
----
S
S
L
M
L
R
R
G
Y
S
Y
S
L
G
V
T
-
N
S
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
H
D
L
E
K
G
F
L
T
V
Q
K
R
L
N
-----
G
--
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
D
-
A
N
D
Y
F
G
S
A
L
L
--
4
PsiBlast_PDB
72.41
37%
18
- C6 -
2Y4E
5
EFEB_ECOLI
A:
[20-401]
------------------------------------------
S
A
P
G
T
L
S
P
D
A
R
N
E
K
Q
--
P
F
Y
G
E
H
Q
A
G
I
L
T
P
Q
Q
A
A
M
M
L
V
A
F
D
V
---------
L
A
-
S
-------
D
K
A
D
L
E
R
L
F
R
L
L
T
Q
R
F
A
F
L
T
Q
G
G
A
-
A
--
P
E
T
P
-
N
P
R
L
P
P
L
D
S
G
I
L
---
G
G
Y
--
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
-----
E
R
F
G
L
A
P
Q
M
P
K
K
L
Q
K
M
T
R
F
P
N
D
S
L
D
A
A
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
---
I
S
D
H
A
A
R
S
K
----
G
K
E
----
T
P
I
N
L
L
G
F
K
D
G
T
A
N
P
D
S
Q
N
D
K
L
M
Q
K
V
V
W
V
--
T
A
-
D
QQ
E
P
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
P
L
K
E
Q
Q
T
I
F
G
R
D
K
Q
T
G
A
P
L
-
G
M
Q
H
E
H
---
D
V
P
D
Y
--------
A
----------
S
--------
D
P
E
GKVIAL
D
S
H
I
R
L
A
N
PRT
A
---
E
---
S
-
E
----
S
S
L
M
L
R
R
G
Y
S
Y
S
L
G
V
T
-
N
S
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
H
D
L
E
K
G
F
L
T
V
Q
K
R
L
N
-----
G
--
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
D
-
A
N
D
Y
F
G
S
A
L
L
--
22
PsiBlast_CBE
72.34
37%
19
- C6 -
2Y4E
3
EFEB_ECOLI
B:
[20-401]
------------------------------------------
S
A
P
G
T
L
S
P
D
A
R
N
E
K
Q
--
P
F
Y
G
E
H
Q
A
G
I
L
T
P
Q
Q
A
A
M
M
L
V
A
F
D
V
---------
L
A
-
S
-------
D
K
A
D
L
E
R
L
F
R
L
L
T
Q
R
F
A
F
L
T
Q
G
G
A
-
A
--
P
E
T
P
-
N
P
R
L
P
P
L
D
S
G
I
L
---
G
G
Y
--
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
-----
E
R
F
G
L
A
P
Q
M
P
K
K
L
Q
K
M
T
R
F
P
N
D
S
L
D
A
A
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
---
I
S
D
HAAR
S
K
----
G
K
E
----
T
P
I
N
L
L
G
F
K
D
G
T
A
N
P
D
S
Q
N
D
K
L
M
Q
K
V
V
W
V
--
T
A
-
D
QQ
E
P
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
P
L
K
E
Q
Q
T
I
F
G
R
D
K
Q
T
G
A
P
L
-
G
M
Q
H
E
H
---
D
V
P
D
Y
--------
A
----------
S
--------
D
P
E
GKVIAL
D
S
H
I
R
L
ANPRT
A
---
E
---
S
-
E
----
S
S
L
M
L
R
R
G
Y
S
Y
S
L
G
V
T
-
N
S
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
H
D
L
E
K
G
F
L
T
V
Q
K
R
L
N
-----
G
--
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
D
-
A
N
D
Y
F
G
S
A
L
L
--
21
PsiBlast_CBE
72.32
37%
16
- C6 -
2Y4F
6
EFEB_ECOLI
B:
[9-390]
------------------------------------------
S
A
P
G
T
L
S
P
D
A
R
N
E
K
Q
--
P
F
Y
G
E
H
Q
A
G
I
L
T
P
Q
Q
A
A
M
M
L
V
A
F
D
V
---------
L
A
-
S
-------
D
K
A
D
L
E
R
L
F
R
L
L
T
Q
R
F
A
F
L
T
Q
G
G
A
-
A
--
P
E
T
P
-
N
P
R
L
P
P
L
D
S
G
I
L
---
G
G
Y
--
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
-----
E
R
F
G
L
A
P
Q
M
P
K
K
L
Q
K
M
T
R
F
P
N
D
S
L
D
A
A
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
---
I
S
D
HAAR
S
K
----
G
K
E
----
T
P
I
N
L
L
G
F
K
D
G
T
A
N
P
D
S
Q
N
D
K
L
M
Q
K
V
V
W
V
--
T
A
-
D
QQ
E
P
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
P
L
K
E
Q
Q
T
I
F
G
R
D
K
Q
T
G
A
P
L
-
G
M
Q
H
E
H
---
D
V
P
D
Y
--------
A
----------
S
--------
D
P
E
GKVIAL
D
S
H
I
R
L
ANPRT
A
---
E
---
S
-
E
----
S
S
L
M
L
R
R
G
Y
S
Y
S
L
G
V
T
-
N
S
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
H
D
L
E
K
G
F
L
T
V
Q
K
R
L
N
-----
G
--
E
A
L
E
E
Y
V
K
P
I
G
G
G
Y
F
F
A
L
P
G
V
K
D
-
A
N
D
Y
F
G
S
A
L
L
--
26
PsiBlast_CBE
72.19
37%
18
- C6 -
4GT2
5
?
A:
[102-464]
------------------------------------------------------------
F
H
G
K
H
Q
P
G
I
T
T
P
M
Q
A
R
G
H
L
V
A
F
D
L
---------
A
A
G
A
-------
G
R
K
E
A
A
A
L
L
R
R
W
S
D
T
A
R
R
L
M
A
G
E
P
A
G
--
S
----------
R
D
T
D
-
V
---
A
R
D
--
A
G
P
S
S
L
T
V
T
F
G
F
G
H
S
F
F
------
G
R
T
G
L
E
E
Q
R
P
V
A
L
D
P
L
P
D
F
S
S
D
H
L
D
K
N
R
S
N
G
D
L
W
V
Q
I
G
A
D
D
A
L
V
A
F
H
A
L
R
A
I
Q
R
D
A
G
A
A
A
R
V
R
W
Q
M
N
G
F
N
--
R
S
P
----
G
A
----
T
A
H
P
M
--
T
A
R
N
L
M
G
Q
V
D
G
T
R
N
P
K
P
G
E
A
D
F
D
R
R
I
F
V
P
--
E
E
----
G
P
A
--
W
M
A
N
G
S
Y
V
V
V
R
R
I
R
M
L
L
D
D
W
E
E
L
S
L
K
A
Q
E
D
V
I
G
R
R
K
S
D
G
A
P
L
S
G
G
S
G
A
T
---
E
S
T
E
M
--------
D
LEKTDGSGEL
V
--------
V
P
I
------
N
A
H
A
R
I
-----
T
---
R
PDQ
N
-
G
----
G
A
A
M
V
R
R
P
F
S
Y
H
D
G
F
D
-
A
D
G
V
P
D
A
G
L
L
F
V
C
W
Q
A
D
P
L
R
G
F
V
P
V
Q
R
K
L
D
-----
R
G
-
D
A
L
S
Q
F
I
R
H
E
A
S
G
-
L
F
A
V
P
G
G
A
A
-
E
G
E
Y
V
G
Q
R
L
L
E
-
25
PsiBlast_CBE
71.76
37%
15
- C6 -
4GT2
5
?
E:
[102-464]
------------------------------------------------------------
F
H
G
K
H
Q
P
G
I
T
T
P
M
Q
A
R
G
H
L
V
A
F
D
L
---------
A
A
G
A
-------
G
R
K
E
A
A
A
L
L
R
R
W
S
D
T
A
R
R
L
M
A
G
E
P
A
G
--
S
----------
R
D
T
D
-
V
---
A
R
D
--
A
G
P
S
S
L
T
V
T
F
G
F
G
H
S
F
F
------
G
R
T
G
L
E
E
Q
R
P
V
A
L
D
P
L
P
D
F
S
S
D
H
L
D
K
N
R
S
N
G
D
L
W
V
Q
I
G
A
D
D
A
L
V
A
F
H
A
L
R
A
I
Q
R
D
A
G
A
A
A
R
V
R
W
Q
M
N
G
F
N--
R
S
P
----
G
A
----
T
A
H
PM--
T
A
R
N
L
M
G
Q
V
D
G
T
R
N
P
K
P
G
E
A
D
F
D
R
R
I
F
V
P
--
E
E
P-----
A
--
W
M
A
N
G
S
Y
V
V
V
R
R
I
R
M
L
L
D
D
W
E
E
L
S
L
K
A
Q
E
D
V
I
G
R
R
K
S
D
G
A
P
L
S
G
G
S
G
A
T
---
E
S
T
E
M
--------
D
LEKTDGSGEL
V
--------
V
P
I
------
N
A
H
A
R
I
-----
T
---
R
PDQ
N
-
G
----
G
A
A
M
V
R
R
P
F
S
Y
H
D
G
F
D
-
A
D
G
V
P
D
A
G
L
L
F
V
C
W
Q
A
D
P
L
R
G
F
V
P
V
Q
R
K
L
D
-----
R
G
-
D
A
L
S
Q
F
I
R
H
E
A
S
G
-
L
F
A
V
P
G
G
A
A
-
E
G
E
Y
V
G
Q
R
L
L
E
-
34
HHSearch
71.65
38%
19
- C6 -
3O72
2
EFEB_ECO57
A:
[13-387]
----------------------------------------------------
V
A
R
N
E
K
Q
P
F
Y
G
E
H
Q
A
G
I
L
T
P
Q
Q
A
A
M
M
L
V
A
F
D
V
---------
L
A
-
S
-------
D
K
A
D
L
E
R
L
F
R
L
L
T
Q
R
F
A
F
L
T
Q
G
G
A
A
P
--
E
T
P
N
---
P
R
L
P
P
L
D
S
-
G
---
I
L
G
GY
I
A
P
D
N
L
T
I
T
L
S
V
G
H
S
L
F
D
E
-
R
----
F
G
L
A
P
Q
M
P
K
K
L
Q
K
M
T
R
F
P
N
D
S
L
D
A
A
L
C
H
G
D
V
L
L
Q
I
C
A
N
T
Q
D
T
V
I
H
A
L
R
D
I
I
K
H
T
P
D
L
L
S
V
R
W
K
R
E
G
F
---
I
S
D
----
H
A
A
R
S
K
G
K
E
----
T
P
I
N
L
L
G
F
K
D
G
T
A
N
P
D
S
Q
N
D
K
L
M
Q
K
V
V
W
V
--
T
A
-
D
QQ
E
P
A
--
W
T
I
G
G
S
Y
Q
A
V
R
L
I
Q
F
R
V
E
F
W
D
R
T
P
L
K
E
Q
Q
T
I
F
G
R
D
K
Q
T
G
A
P
L
-
G
M
Q
H
E
H
---
D
V
P
D
Y
--------
A
SDPEGK----
G
--------
I
A
L
------
D
S
H
I
R
L
-----
A
---
N
---
P
R
T
AESE
S
S
L
M
L
R
R
G
Y
S
Y
S
L
G
V
T
N
S
-
G
Q
L
D
M
G
L
L
F
V
C
Y
Q
H
D
L
E
K
G
F
L
T
V
Q
K
R
L
N
------
G
-
E
A
L
E
E
Y
V
K
P
I
G
G
G
-
Y
F
F
A
L
P
G
V
K
D
A
N
D
Y
L
G
S
A
L
L
R
-
6
PsiBlast_PDB
71.60
37%
16
- C6 -
4GT2
6
?
B:
[102-464]
------------------------------------------------------------
F
H
G
K
H
Q
P
G
I
T
T
P
M
Q
A
R
G
H
L
V
A
F
D
L
---------
A
A
G
A
-------
G
R
K
E
A
A
A
L
L
R
R
W
S
D
T
A
R
R
L
M
A
G
E
P
A
G
--
S
----------
R
D
T
D
-
V
---
A
R
D
--
A
G
P
S
S
L
T
V
T
F
G
F
G
H
S
F
F
------
G
R
T
G
L
E
E
Q
R
P
V
A
L
D
P
L
P
D
F
S
S
D
H
L
D
K
N
R
S
N
G
D
L
W
V
Q
I
G
A
D
D
A
L
V
A
F
H
A
L
R
A
I
Q
R
D
A
G
A
A
A
R
V
R
W
Q
M
N
G
F
N
--
R
S
P
----
G
A
----
T
A
H
P
M
--
T
A
R
N
L
M
G
Q
V
D
G
T
R
N
P
K
P
G
E
A
D
F
D
R
R
I
F
V
P
--
E
------
P
A
--
W
M
A
N
G
S
Y
V
V
V
R
R
I
R
M
L
L
D
D
W
E
E
L
S
L
K
A
Q
E
D
V
I
G
R
R
K
S
D
G
A
P
L
S
G
G
S
G
A
T
---
E
S
T
E
M
--------
D
LEKTDGSGEL
V
--------
V
P
I
------
N
A
H
A
R
I
-----
T
---
R
PDQ
N
-
G
----
G
A
A
M
V
R
R
P
F
S
Y
H
D
G
F
D
-
A
D
G
V
P
D
A
G
L
L
F
V
C
W
Q
A
D
P
L
R
G
F
V
P
V
Q
R
K
L
D
-----
R
G
-
D
A
L
S
Q
F
I
R
H
E
A
S
G
-
L
F
A
V
P
G
G
A
A
-
E
G
E
Y
V
G
Q
R
L
L
E
-
33
HHSearch
71.54
36%
29
* C6 *
4GT2
6
?
B:
[89-465]
-----------------------------------------------
A
T
P
L
T
S
L
G
S
E
R
A
M
F
H
G
K
H
Q
P
G
I
T
T
P
M
Q
A
R
G
H
L
V
A
F
D
L
---------
A
A
-
G
A------
G
R
K
E
A
A
A
L
L
R
R
W
S
D
T
A
R
R
L
M
A
G
E
P
A
G
-------------
S
R
D
T
-
D
---
V
A
R
D-
A
G
P
S
S
L
T
V
T
F
G
F
G
H
S
F
F
G
R
------
T
G
L
E
E
Q
R
P
V
A
L
D
P
L
P
D
F
S
S
D
H
L
D
K
N
R
S
N
G
D
L
W
V
Q
I
G
A
D
D
A
L
V
A
F
H
A
L
R
A
I
Q
R
D
A
G
A
A
A
R
V
R
W
Q
M
N
G
F
---
N
R
S
----
P
G
ATA-
H
P
M
----
T
A
R
N
L
M
G
Q
V
D
G
T
R
N
P
K
P
G
E
A
D
F
-
D
R
R
I
F
V
--
P
E
-----
P
A
--
W
M
A
N
G
S
Y
V
V
V
R
R
I
R
M
L
L
D
D
W
E
E
L
S
L
K
A
Q
E
D
V
I
G
R
R
K
S
D
G
A
P
L
-
S
G
G
S
G
A
TES
T
E
M
D
L
EKTDGSGE
L
----------
V
--------
V
P
I
------
N
A
H
A
R
I
-----
T
---
R
---
P
D
Q
NG--
G
A
A
M
V
R
R
P
F
S
Y
H
D
G
F
D
A
D
-
G
V
P
D
A
G
L
L
F
V
C
W
Q
A
D
P
L
R
G
F
V
P
V
Q
R
K
L
D
-----
R
G
-
D
A
L
S
Q
F
I
R
H
E
A
S
G
-
L
F
A
V
P
G
G
A
A
-
E
G
E
Y
V
G
Q
R
L
L
E
G
24
PsiBlast_CBE
71.50
37%
18
- C6 -
4GT2
5
?
G:
[102-464]
------------------------------------------------------------
F
H
G
K
H
Q
P
G
I
T
T
P
M
Q
A
R
G
H
L
V
A
F
D
L
---------
A
A
G
A
-------
G
R
K
E
A
A
A
L
L
R
R
W
S
D
T
A
R
R
L
M
A
G
E
P
A
G
--
S
----------
R
D
T
D
-
V
---
A
R
D
--
A
G
P
S
S
L
T
V
T
F
G
F
G
H
S
F
F
------
G
R
T
G
L
E
E
Q
R
P
V
A
L
D
P
L
P
D
F
S
S
D
H
L
D
K
N
R
S
N
G
D
L
W
V
Q
I
G
A
D
D
A
L
V
A
F
H
A
L
R
A
I
Q
R
D
A
G
A
A
A
R
V
R
W
Q
M
N
G
F
N--
R
S
P
----
G
A
----
T
A
H
PM--
T
A
R
N
L
M
G
Q
V
D
G
T
R
N
P
K
P
G
E
A
D
F
D
R
R
I
F
V
P
--
E
------
P
A
--
W
M
A
N
G
S
Y
V
V
V
R
R
I
R
M
L
L
D
D
W
E
E
L
S
L
K
A
Q
E
D
V
I
G
R
R
K
S
D
G
A
P
L
S
G
G
S
G
A
T
---
E
S
T
E
M
--------
D
LEKTDGSGEL
V
--------
V
P
I
------
N
A
H
A
R
I
-----
T
---
R
PDQ
N
-
G
----
G
A
A
M
V
R
R
P
F
S
Y
H
D
G
F
D
-
A
D
G
V
P
D
A
G
L
L
F
V
C
W
Q
A
D
P
L
R
G
F
V
P
V
Q
R
K
L
D
-----
R
G
-
D
A
L
S
Q
F
I
R
H
E
A
S
G
-
L
F
A
V
P
G
G
A
A
-
E
G
E
Y
V
G
Q
R
L
L
E
-
32
HHSearch
71.36
40%
39
- C6 -
4GRC
2
?
A:
[76-437]
--------------------------------------------------------
S
A
V
P
F
H
G
A
H
Q
A
G
I
A
T
P
V
Q
D
R
L
H
F
A
A
F
D
V
---------
T
T
-
E
-------
D
R
A
A
F
V
A
L
L
K
E
W
T
A
A
A
R
R
L
T
A
G
H
A
V
G
--
E
G
A
Y
G
G
L
P
E
A
P
P
D
D
T
-
G
---
E
A
L
G-
L
K
P
S
R
L
T
L
T
I
G
F
G
P
S
L
F
T
R
------
F
G
L
A
D
L
R
P
E
A
L
A
D
L
P
K
F
P
G
D
N
L
D
R
A
R
S
G
G
D
L
C
V
Q
A
C
A
D
D
P
Q
V
A
V
H
A
I
R
N
L
A
R
I
G
F
G
K
V
V
V
R
W
S
Q
L
G
F
---
G
K
T
----
S
S
TTP-
D
E
Q
----
T
P
R
N
L
L
G
F
K
D
G
T
R
N
I
A
G
T
E
K
D
R
L
D
R
F
V
W
A
--
A
E
K
D
--
G
T
P
--
W
M
T
G
G
S
Y
L
V
A
R
R
I
R
M
H
I
E
T
W
D
R
A
S
L
Q
E
Q
E
D
V
F
G
R
D
K
G
E
G
A
P
V
-
G
K
A
K
E
R
---
D
E
P
F
L
--------
K
----------
A
--------
M
K
P
------
D
A
H
V
R
L
-----
A
---
H
---
P
D
S
NG--
G
A
T
L
L
R
R
G
Y
S
F
T
D
G
T
D
------
D
A
G
L
F
F
L
A
Y
Q
R
D
I
R
T
G
F
V
P
V
Q
R
N
L
A
------
T
-
D
A
L
N
E
Y
I
Q
H
V
G
S
A
-
V
F
A
V
P
P
G
V
R
D
A
D
D
W
W
G
S
T
L
F
G
-
8
PsiBlast_PDB
68.05
34%
25
- C6 -
5FW4
2
?
A:
[71-429]
-----------------------------------------------------------------
Q
P
G
I
S
G
P
A
P
A
F
V
H
V
I
A
L
D
L
AEEARKN
P
D
T
A
-
R
-------
D
S
A
--
A
A
A
L
R
S
W
T
E
L
A
A
R
L
H
E
E
S
---------------
P
H
D
I
A
-
E
GAA
S
A
G
--
L
L
P
A
S
L
M
V
T
V
G
I
G
G
S
L
L
S
A
I
D
A
E
D
R
------
R
P
D
A
L
A
D
L
P
E
F
S
T
D
D
L
H
P
R
W
C
G
G
D
F
M
L
Q
V
G
A
E
D
P
M
V
L
T
A
A
V
E
E
L
V
A
A
A
A
D
A
T
A
V
R
W
S
L
R
G
F
---
R
R
T
----
A
A
----
A
A
R
DPD
A
T
P
R
N
L
M
G
Q
I
D
G
T
A
N
P
A
Q
D
H
P
L
F
D
R
T
I
T
A
R
--
P
A
-
D
--
N
P
A
HA
W
M
D
G
G
S
Y
L
V
V
R
R
I
R
M
L
L
T
E
W
R
K
L
D
V
A
A
R
E
R
V
I
G
R
R
L
D
T
G
A
P
L
-
G
S
R
N
E
T
----------------------------L-------
I
P
E
------
N
A
H
V
R
L
-----
A
SPE
N
---
N
-
L
----
G
A
R
M
F
R
R
G
Y
S
Y
D
Q
G
W
R
-
D
D
G
V
R
D
A
G
L
L
F
M
A
W
Q
G
D
P
A
T
G
F
I
P
V
Q
R
S
L
A
-----
D
Q
G
D
A
L
N
R
Y
I
R
H
E
G
S
A
-
L
F
A
V
P
-
A
A
R
-
E
G
R
Y
L
G
Q
D
L
I
E
-
35
HHSearch
67.51
34%
35
- C6 -
4GS1
4
?
A:
[24-394]
-------------------------------------------------
Q
R
L
D
M
A
R
R
R
A
D
A
N
A
A
P
Q
P
G
I
S
G
R
A
P
A
F
V
H
V
I
A
F
D
L
---------
A
E
-
P
ARAE
P
A
A
A
R
E
G
A
A
T
A
L
R
T
W
A
E
H
A
A
R
L
H
A
D
G
P
E
G
--
A
-------------------
A
S
A
G-
L
L
P
A
S
L
M
V
T
I
G
I
G
G
S
L
L
E
A
------
M
D
A
A
D
R
R
P
D
A
L
A
D
L
P
E
F
A
T
D
D
L
R
P
R
W
C
G
G
D
L
M
L
Q
V
G
A
E
D
P
M
V
L
A
A
A
V
D
E
L
V
A
A
T
A
P
T
T
T
V
R
W
S
L
R
G
F
---
R
R
T
----
A
A
AAQD
P
D
A
----
T
P
R
N
L
M
G
Q
I
D
G
T
A
N
P
A
Q
D
H
P
L
F
-
T
R
T
V
T
A
--
P
P
A
D
DP
A
H
A
--
W
M
D
G
G
S
Y
L
V
V
R
R
I
R
M
L
L
D
E
W
R
R
L
D
V
P
D
R
E
R
V
I
G
R
H
L
D
T
G
A
P
L
-
G
G
E
K
E
T
---
D
P
V
V
L
--------
T
ARDADGRL--
V
--------
I
P
E
------
D
A
H
V
R
L
-----
A
---
N
---
P
E
N
NL--
G
A
R
M
V
R
R
G
Y
N
Y
D
E
G
W
R
D
D
-
G
V
R
D
A
G
L
L
F
M
A
W
Q
G
N
P
A
T
G
F
V
P
V
Q
R
S
L
V
E
----
Q
G
-
D
A
L
N
R
Y
T
R
H
E
G
S
A
-
L
F
A
V
P
A
A
T
--
A
D
R
Y
P
G
Q
D
L
V
E
-
7
PsiBlast_PDB
59.38
36%
45
- C6 -
4GS1
4
?
A:
[97-394]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
G
--
L
L
P
A
S
L
M
V
T
I
G
I
G
G
S
L
L
E
A
M
D
A
A
D
R
------
R
P
D
A
L
A
D
L
P
E
F
A
T
D
D
L
R
P
R
W
C
G
G
D
L
M
L
Q
V
G
A
E
D
P
M
V
L
A
A
A
V
D
E
L
V
A
A
T
A
P
T
T
T
V
R
W
S
L
R
G
F
---
R
R
T
----
A
A
----
A
A
Q
DPD
A
T
P
R
N
L
M
G
Q
I
D
G
T
A
N
P
A
Q
D
H
P
L
F
T
R
T
V
T
A
P
--
P
A
-
D
--
D
P
A
HA
W
M
D
G
G
S
Y
L
V
V
R
R
I
R
M
L
L
D
E
W
R
R
L
D
V
P
D
R
E
R
V
I
G
R
H
L
D
T
G
A
P
L
-
G
G
E
K
E
T
---
D
P
V
V
L
--------
T
----------
A
RDADGRLV
I
P
E
------
D
A
H
V
R
L
-----
A
NPE
N
---
N
-
L
----
G
A
R
M
V
R
R
G
Y
N
Y
D
E
G
W
R
-
D
D
G
V
R
D
A
G
L
L
F
M
A
W
Q
G
N
P
A
T
G
F
V
P
V
Q
R
S
L
V
-----
E
Q
G
D
A
L
N
R
Y
T
R
H
E
G
S
A
-
L
F
A
V
P
A
A
T
A
-
D
-
R
Y
P
G
Q
D
L
V
E
-
27
PsiBlast_CBE
58.79
36%
49
- C6 -
4GS1
4
?
B:
[97-394]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
G
--
L
L
P
A
S
L
M
V
T
I
G
I
G
G
S
L
L
E
A
M
D
A
A
D
R
------
R
P
D
A
L
A
D
L
P
E
F
A
T
D
D
L
R
P
R
W
C
G
G
D
L
M
L
Q
V
G
A
E
D
P
M
V
L
A
A
A
V
D
E
L
V
A
A
T
A
P
T
T
T
V
R
W
S
L
R
G
F
---
R
R
T
----
A
A
----
A
A
Q
DPDA
T
P
R
N
L
M
G
Q
I
D
G
T
A
N
P
A
Q
D
H
P
L
F
T
R
T
V
T
A
P
--
P
A
-
D
--
D
P
A
HA
W
M
D
G
G
S
Y
L
V
V
R
R
I
R
M
L
L
D
E
W
R
R
L
D
V
P
D
R
E
R
V
I
G
R
H
L
D
T
G
A
P
L
-
G
G
E
K
E
T
---
D
P
V
V
L
--------
T
----------
A
RDADGRLV
I
P
E
------
D
A
H
V
R
L
-----
A
NPE
N
---
N
-
L
----
G
A
R
M
V
R
R
G
Y
N
Y
D
E
G
W
R
-
D
D
G
V
R
D
A
G
L
L
F
M
A
W
Q
G
N
P
A
T
G
F
V
P
V
Q
R
S
L
V
-----
E
Q
G
D
A
L
N
R
Y
T
R
H
E
G
S
A
-
L
F
A
V
P
A
A
T
A
-
D
-
R
Y
P
G
Q
D
L
V
E
-
38
HHSearch
55.91
23%
-68
- C6 -
5DE0
1
?
A:
[6-301]
---------------------------------------------------------------
K
S
Q
T
A
I
L
P
E
A
G
P
F
A
L
Y
T
L
L
K
V
---------
R
Q
-
N
--------
H
A
H
V
L
Q
A
L
K
A
L
P
A
L
V
E
E
I
N
Q
N
-------------------------------
Q
P
G
A
E
L
T
V
S
V
A
F
S
K
G
F
W
S
H
------
F
E
M
A
--
S
P
P
E
L
I
D
F
P
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L
G
E
G
E
T
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A
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D
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L
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L
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G
I
S
D
I
A
Q
D
I
E
I
V
D
E
T
Y
G
F
---
R
Y
L
----
D
A
-------------
R
D
M
T
G
F
I
D
G
T
E
N
P
K
A
E
K
R
---
A
E
V
A
L
V
--
A
D
------
G
--
D
F
A
G
G
S
Y
V
M
V
Q
R
F
V
H
N
L
P
A
W
N
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L
N
L
A
A
Q
E
K
V
I
G
R
T
K
P
D
S
V
E
L
-
E
--------------------------------
N
--------
V
P
A
------
A
S
H
V
G
R
-----
V
---
D
---
I
K
E
EGK-
G
L
K
I
V
R
H
S
L
P
Y
G
S
V
S
------
G
D
H
G
L
L
F
I
A
Y
C
H
T
L
-
H
N
F
K
T
M
L
E
S
M
Y
GVTDG
K
T
-
D
Q
L
L
R
F
T
K
A
V
T
G
A
-
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F
F
A
P
S
Q
V
--
M
L
Q
E
L
T
------