@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00067_CP3A5_: (2014-08-13 )
MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE
Atome Classification :
(15 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200........210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.....-..390--.......400.......410........420-.......430.......440.......450.......460.......470.......480.......490.......500
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDLIP
N
L
A
V
E
T
W
L
L
L
A
V
S
L
V
L
L
Y
L
YGTR
T
H
G
L
F
K
R
LGIPGPT
P
L
P
L
L
G
N
V
L
S
Y
R
Q
G
L
W
KF
D
T
E
C
Y
K
K
Y
G
K
MWGTYEGQ
L
P
V
L
A
IT
D
P
D
V
I
R
T
V
L
V
K
E
C
Y
S
V
F
TNRRSLG
P
V
G
F
M
K
S
A
I
SLA
E
D
E
E
W
K
R
I
R
S
L
LSPTFTSG
K
L
K
E
M
F
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
EKGK
P
V
T
L
K
D
I
F
G
A
Y
S
M
D
V
I
TGTSF
G
V
N
IDSLNNPQ-D
P
F
V
E
S
T
K
K
F
L
K
FGFL
D
P
L
F
L
S
I
I
L
F
P
F
L
T
P
V
F
E
A
LNVSLFP
K
D
T
I
N
F
L
S
K
S
V
N
R
M
K
K
S
RLN
D
K
Q
K
H
R
L
D
F
L
Q
L
M
IDSQNSKE
T
E
S
H
K
A
L
S
D
L
E
L
A
A
Q
S
I
I
F
I
F
AGYE
T
T
S
S
V
L
S
F
T
L
Y
E
LATH
P
D
V
Q
Q
K
L
Q
K
E
I
D
A
VLPNKAPP
T
Y
D
A
V
V
Q
M
E
Y
L
D
M
V
V
NE
T
L
R
L
F
P
V
A
I
R
L
E
R
T
CKKD
V
E
I
N
G
V
F
-IPKG
S
--
M
V
V
I
P
T
Y
A
LHHDPKYWT
E
P
-
E
EF
R
P
E
R
FSKK-KDSID
P
Y
I
YTPFGTGP
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
NFSFKPCKETQI
P
L
K
LDTQGLLQPEK
P
I
V
L
K
VDSRDGTLSGE
16
PsiBlast_PDB
97.69
84%
-119
- C2 -
3NXU
6
CP3A4_HUMAN
A:
[7-474]
----------------------------
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
-
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
---
R
V
D
F
L
Q
L
M
I
D
S
Q
N
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
-
I
P
K
G
V
--
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
-
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------
3
PsiBlast_PDB
97.39
83%
-117
- C2 -
4I3Q
1
CP3A4_HUMAN
A:
[8-477]
---------------------------
H
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
-
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
Q
K
H
R
V
D
F
L
Q
L
M
I
D
S
Q
N
S
-----
H
K
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
-
I
P
K
G
V
--
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
-
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
D
------
24
PsiBlast_CBE
97.10
84%
-116
- C2 -
3NXU
4
CP3A4_HUMAN
B:
[7-474]
----------------------------
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
-
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
---
R
V
D
F
L
Q
L
M
I
D
S
Q
N
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
-
I
P
K
G
V
--
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
-
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------
2
PsiBlast_PDB
97.07
83%
-117
- C2 -
3TJS
2
CP3A4_HUMAN
A:
[9-476]
----------------------------
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
-
D
P
F
V
E
N
T
K
K
L
L
-------
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
----
H
R
V
D
F
L
Q
L
M
I
D
S
Q
N
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
-
I
P
K
G
V
--
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
-
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------
11
PsiBlast_PDB
96.99
83%
-115
- C2 -
1TQN
1
CP3A4_HUMAN
A:
[7-478]
---------------------------
H
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
-
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
Q
K
H
R
V
D
F
L
Q
L
M
I
D
S
Q
N
S
----
S
H
K
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
-
I
P
K
G
V
--
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
-
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
D
G
T
----
1
PsiBlast_PDB
96.81
83%
-119
- C2 -
3UA1
2
CP3A4_HUMAN
A:
[8-476]
---------------------------
H
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
-
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
---
E
D
T
Q
---
V
D
F
L
Q
L
M
I
D
S
Q
-------
H
K
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
-
I
P
K
G
V
--
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
-
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------
5
PsiBlast_PDB
96.80
83%
-117
- C2 -
4I4H
2
CP3A4_HUMAN
A:
[9-476]
----------------------------
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
-
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
---
R
V
D
F
L
Q
L
M
I
D
S
Q
N
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
-
I
P
K
G
V
--
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
-
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------
4
PsiBlast_PDB
96.79
83%
-115
- C2 -
4I4G
2
CP3A4_HUMAN
A:
[7-476]
--------------------------
T
H
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
-
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
---
R
V
D
F
L
Q
L
M
I
D
S
Q
N
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
-
I
P
K
G
V
--
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
-
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------
6
PsiBlast_PDB
96.62
83%
-119
- C2 -
4K9T
3
CP3A4_HUMAN
A:
[9-477]
----------------------------
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
-
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
-----
D
F
L
Q
L
M
I
D
S
Q
---------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
-
I
P
K
G
V
--
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
-
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
D
------
13
PsiBlast_PDB
96.52
84%
-115
- C2 -
1W0F
2
CP3A4_HUMAN
A:
[3-476]
------------------------
Y
G
T
H
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
-
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
-------
V
D
F
L
Q
L
M
I
D
S
Q
N
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
-
I
P
K
G
V
--
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
-
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
D
G
-----
8
PsiBlast_PDB
96.32
83%
-120
- C2 -
4K9V
2
CP3A4_HUMAN
A:
[8-476]
---------------------------
H
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
-
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
----
V
D
F
L
Q
L
M
I
D
S
Q
---------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
-
I
P
K
G
V
--
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
-
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------
14
PsiBlast_PDB
95.76
84%
-114
- C2 -
1W0G
2
CP3A4_HUMAN
A:
[3-476]
------------------------
Y
G
T
H
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
-
D
P
F
V
E
N
T
K
K
L
L
R
F
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
-------
F
L
Q
L
M
I
------------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
-
I
P
K
G
V
--
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
-
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
D
G
-----
10
PsiBlast_PDB
95.70
83%
-119
- C2 -
4K9X
2
CP3A4_HUMAN
A:
[9-476]
----------------------------
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
-------
N
T
K
K
L
L
--
D
F
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
T
---
R
V
D
F
L
Q
L
M
I
D
S
Q
N
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
-
I
P
K
G
V
--
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
-
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------
7
PsiBlast_PDB
95.09
83%
-120
- C2 -
4K9U
3
CP3A4_HUMAN
A:
[7-476]
--------------------------
T
H
S
H
G
L
F
K
K
L
G
I
P
G
P
T
P
L
P
F
L
G
N
I
L
S
Y
H
K
G
F
C
M
F
D
M
E
C
H
K
K
Y
G
K
V
W
G
F
Y
D
G
Q
Q
P
V
L
A
I
T
D
P
D
M
I
K
T
V
L
V
K
E
C
Y
S
V
F
T
N
R
R
P
F
G
P
V
G
F
M
K
S
A
I
S
I
A
E
D
E
E
W
K
R
L
R
S
L
L
S
P
T
F
T
S
G
K
L
K
E
M
V
P
I
I
A
Q
Y
G
D
V
L
V
R
N
L
R
R
E
A
E
T
G
K
P
V
T
L
K
D
V
F
G
A
Y
S
M
D
V
I
T
S
T
S
F
G
V
N
I
D
S
L
N
N
P
Q
-
D
P
F
V
E
N
T
K
K
------
L
D
P
F
F
L
S
I
T
V
F
P
F
L
I
P
I
L
E
V
L
N
I
C
V
F
P
R
E
V
T
N
F
L
R
K
S
V
K
R
M
K
E
S
R
L
E
D
------
D
F
L
Q
L
M
I
D
S
Q
N
--------
A
L
S
D
L
E
L
V
A
Q
S
I
I
F
I
F
A
G
Y
E
T
T
S
S
V
L
S
F
I
M
Y
E
L
A
T
H
P
D
V
Q
Q
K
L
Q
E
E
I
D
A
V
L
P
N
K
A
P
P
T
Y
D
T
V
L
Q
M
E
Y
L
D
M
V
V
N
E
T
L
R
L
F
P
I
A
M
R
L
E
R
V
C
K
K
D
V
E
I
N
G
M
F
-
I
P
K
G
V
--
V
V
M
I
P
S
Y
A
L
H
R
D
P
K
Y
W
T
E
P
-
E
K
F
L
P
E
R
F
S
K
K
N
K
D
N
I
D
P
Y
I
Y
T
P
F
G
S
G
P
R
N
C
I
G
M
R
F
A
L
M
N
M
K
L
A
L
I
R
V
L
Q
N
F
S
F
K
P
C
K
E
T
Q
I
P
L
K
L
S
L
G
G
L
L
Q
P
E
K
P
V
V
L
K
V
E
S
R
-------
18
PsiBlast_PDB
58.65
30%
-87
- C2 -
4DUE
2
CPXB_BACME
A:
[89-456]
----------------------------------------------------------------------------------------------------------------------
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
-
L
N
A
D
E
H
I
E
V
P
E
D
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
-----
D
E
A
M
N
K
L
Q
R
A
--
D
D
P
A
Y
D
E
-
N
K
R
Q
F
Q
E
D
-
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
D
-
D
L
L
T
H
M
L
---
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
S
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
-
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
--
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
-
E
N
-
P
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
H
T
N
Y
E
L
D
I
K
-
E
T
Q
-
L
L
K
P
E
G
-
F
V
V
K
A
K
S
K
K
I
P
L
G
--