@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_DAPK2_: (2014-08-15 )
MFQASMRSPNMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRRESVVNLENFRKQYVRRRWKLSFSIVSLCNHLTRSLMKKVHLRPDEDLRNCESDTEEDIARRKALHPRRRSSTS
Atome Classification :
(24 SA)
.........10...-.-....20....-...--.30........40........50........60........70........80.-.......90........100.......110......-.120.......130.......140.......150.......160.......170.......180........190.......200.......210.......220.......230..-.....240.......250.......260.......270.......280.......290.-.--.....300.......310.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFQASMRSPNME
P
F
-
K
-
Q
Q
K
V
E
D
F
Y
D
I
-
G
E
E
--LGSG
Q
F
A
I
V
K
K
C
R
EKST
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
SRRGV
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
-HHN
V
I
T
L
H
D
V
YENRT
D
V
V
L
I
L
E
LVSG
G
E
L
F
D
F
L
A
Q
K
-ESL
S
E
E
E
A
T
S
F
I
K
Q
I
L
DGV
N
Y
L
H
T
K
K
I
A
H
FDLKPE
N
I
M
L
L
DKNIPIP
H
I
K
L
I
DFG
L
A
H
E
IEDG-V
E
F
K
N
IFGTPEFVAPEIVNYEPLGLEA
D
M
W
S
I
G
V
I
T
Y
I
L
LSGASPFLGD
T
K
Q
E
-
T
L
A
N
I
T
A
V
S
YD
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
LRHPWITPVD
N
Q
Q
A
-
M
--
V
R
R
E
SVV
N
L
E
N
F
R
K
Q
Y
V
R
R
R
W
K
L
S
F
S
I
V
S
L
C
N
H
L
T
R
S
L
M
K
KVHLRP
D
E
D
L
R
NCESD
T
E
E
D
I
A
R
R
KALHPRRRSSTS
26
PsiBlast_CBE
90.13
99%
-111
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[3-302]
-----------
E
P
F
-
K
-
Q
Q
K
V
E
D
F
Y
D
I
-
G
E
E
--
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
-
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
-
M
--
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
-----------------------------------------------------------
2
PsiBlast_PDB
89.39
97%
-104
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[3-302]
-----------
E
T
F
-
K
-
Q
Q
K
V
E
D
F
Y
D
I
-
G
E
E
--
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
C
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
-
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
T
Q
Q
A
-
M
--
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
-----------------------------------------------------------
5
PsiBlast_PDB
89.11
99%
-109
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[2-302]
----------
M
E
P
F
-
K
-
Q
Q
K
V
E
D
F
Y
D
I
-
G
E
E
--
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
-
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
-
M
--
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
-----------------------------------------------------------
22
PsiBlast_CBE
88.77
97%
-107
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[4-302]
------------
T
F
-
K
-
Q
Q
K
V
E
D
F
Y
D
I
-
G
E
E
--
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
C
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
-
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
T
Q
Q
A
-
M
--
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
-----------------------------------------------------------
25
PsiBlast_CBE
86.90
99%
-109
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[3-302]
-----------
E
P
F
-
K
-
Q
Q
K
V
E
D
F
Y
D
I
-
G
E
E
--
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
-
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
-
M
--
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
-----------------------------------------------------------
24
PsiBlast_CBE
86.53
99%
-107
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[3-302]
-----------
E
P
F
-
K
-
Q
Q
K
V
E
D
F
Y
D
I
-
G
E
E
--
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
-
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
N
Q
Q
A
-
M
--
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
-----------------------------------------------------------
12
PsiBlast_PDB
81.43
75%
-97
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[2-302]
-----------
T
V
F
-
R
-
Q
E
N
V
D
D
Y
Y
D
T
-
G
E
E
--
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
-
L
--
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
----------------------------------------------------------
56
HHSearch
81.33
75%
-100
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[3-302]
------------
V
F
-
R
-
Q
E
N
V
D
D
Y
Y
D
T
-
G
E
E
--
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
-
L
--
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
----------------------------------------------------------
10
PsiBlast_PDB
78.15
72%
-97
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[2-302]
-----------
T
V
F
-
R
-
Q
E
N
V
D
D
Y
Y
D
T
-
G
E
E
--
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
-
N
E
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
-
L
--
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
----------------------------------------------------------
11
PsiBlast_PDB
77.82
72%
-95
- C1 -
4B4L
3
DAPK1_HUMAN
A:
[7-305]
---------------
R
-
Q
E
N
V
D
D
Y
Y
D
T
-
G
E
E
--
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
-
L
--
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
A
K
---------------------------------------------------------
15
PsiBlast_PDB
76.98
77%
-109
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[2-278]
-----------
T
V
F
-
R
-
Q
E
N
V
D
D
Y
Y
D
T
-
G
E
E
--
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
-------------------------------------------------------------------------------------
19
PsiBlast_PDB
72.62
78%
-105
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[2-277]
-----------
T
V
F
-
R
-
Q
E
N
V
D
D
Y
Y
D
T
-
G
E
E
--
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
--------------------------------------------------------------------------------------
40
PsiBlast_CBE
72.51
78%
-109
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[4-276]
-------------
F
-
R
-
Q
E
N
V
D
D
Y
Y
D
T
-
G
E
E
--
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
-
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---------------------------------------------------------------------------------------
38
PsiBlast_CBE
64.59
77%
-129
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[7-276]
------------------
E
N
V
D
D
Y
Y
D
T
-
G
E
E
--
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----------
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
-----
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-----------
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---------------------------------------------------------------------------------------
39
PsiBlast_CBE
63.42
77%
-117
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[5-276]
---------------
R
-
Q
E
N
V
D
D
Y
Y
D
T
-
G
E
E
--
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
------------
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---------------------------------------------------------------------------------------
69
HHSearch
60.96
48%
-112
* C1 *
2X4F
4
MYLK4_HUMAN
A:
[80-349]
-------------
A
-
K
-
Q
G
A
V
N
S
F
Y
T
V
-
S
K
T
EI
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
K
------
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
D
-
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
--
A
K
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
-
E
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
-
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
-------------------------------------------------------------------------------------
17
PsiBlast_PDB
60.37
77%
-120
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[7-276]
------------------
E
N
V
D
D
Y
Y
D
T
-
G
E
E
--
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
--------
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-------------
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
-
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
---------------------------------------------------------------------------------------
70
HHSearch
57.94
35%
-105
- C1 -
3Q5I
1
?
A:
[23-342]
--------
P
G
M
Y
V
R
-
K
K
E
G
K
I
G
E
S
Y
F
K
-
V
R
K
--
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
---------
K
F
H
E
E
I
Y
N
E
I
S
L
L
K
S
L
D
-
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
-
H
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
N
-
S
L
L
N
I
K
I
V
D
F
G
L
S
S
F
F
S
K
D
-
Y
K
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
K
-
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
N
D
Q
D
-
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
A
L
N
S
R
W
I
K
K
Y
A
N
N
I
N
K
S
--
D
Q
K
T
L
C
G
A
L
S
N
M
R
K
F
E
G
S
Q
K
L
A
Q
A
A
I
L
-------------------------------------------------
68
HHSearch
52.35
46%
-108
- C1 -
3LM5
1
ST17B_HUMAN
A:
[16-296]
--------
E
N
L
Y
F
Q
-
S
-
M
E
N
F
N
N
F
Y
I
L
T
S
K
E
--
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
R
R
G
Q
----
D
C
R
A
E
I
L
H
E
I
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
E
L
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
S
S
-
I
Y
P
L
G
D
I
K
I
V
D
F
G
M
S
R
K
I
----------
M
G
T
P
E
Y
L
A
P
E
I
L
N
Y
D
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
D
N
Q
E
-
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
Q
Q
W
D
F
-----------------------------------------------------------------------------------
65
HHSearch
49.35
36%
-94
- C1 -
3LIJ
1
?
A:
[23-332]
-------
T
P
G
M
F
I
T
S
K
-
K
G
H
L
S
E
M
Y
Q
R
-
V
K
K
--
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
---------
S
S
N
S
K
L
L
E
E
V
A
V
L
K
L
L
D
-
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
-
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
E
-
K
D
A
L
I
K
I
V
D
F
G
L
S
A
V
F
E
N
Q
-
K
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
-
K
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
D
Q
E
-
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
E
M
C
S
K
K
E
-
S
---
L
P
S
L
A
N
A
I
E
N
M
R
K
F
Q
N
S
Q
K
L
A
Q
A
A
L
--------------------------------------------------
64
HHSearch
46.30
34%
-84
- C1 -
3MWU
1
?
A:
[14-317]
------------
L
Y
-
F
-
Q
G
T
F
A
E
R
Y
N
I
-
V
C
M
--
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
----
N
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
-
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
-----
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
-
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
-
T
IS
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
--------------------------------------------------
62
HHSearch
44.41
36%
-81
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-301]
------------------
T
R
F
T
E
E
Y
Q
L
-
F
E
E
--
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
K
L
S
A
----
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
-
L
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
E
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
-
C
--
M
H
R
Q
--
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
-----------------------------------------------------
71
HHSearch
40.37
37%
-82
- C1 -
2JAM
4
KCC1G_HUMAN
A:
[6-290]
-------------------
N
I
R
K
T
F
I
F
-
M
E
V
--
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
------------
S
S
L
E
N
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
-
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
K
M
E
Q
N
G
-
I
-
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
-
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
------
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
S
---------------------------------------------------------
67
HHSearch
37.70
38%
-92
- C1 -
2W4O
1
KCC4_HUMAN
A:
[49-346]
------------------
D
A
L
S
D
F
F
E
V
-
E
S
E
--
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
------------------
I
G
V
L
L
R
L
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
-
G
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
-
A
P
D
A
P
L
K
I
A
D
F
-----------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
K
A
A
N
F
V
-------
H
M
D
T
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
--------------------------------------------