@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_STK24_: (2014-08-19 )
MDSRAQLWGLALNKRRATLPHPGGSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYSLSGGGTSSH
Atome Classification :
(19 SA)
.........10........20.......--.30........40........50........60........70........80........90........100...-------....110......--.120..--.-.--...130.......140.......150........160.......170.......180.......190.......200.-----.-----.-....210.......220.......230.......------240--------..---......250-.--.--......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDSRA
Q
L
W
G
L
A
LNKRRATLPHPGGSTNL--KA
D
P
E
E
L
F
T
K
L
E
K
IGKG
S
F
G
E
V
F
K
G
IDNR
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
QCDS
P
Y
V
T
K
Y
Y
G
S
Y
LKD
T
-------
K
L
W
I
I
M
E
Y
LGGG
S
--
A
L
DLLE--P-G--PL
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
SEHG
E
V
K
L
A
DFGVAGQLTD
T
Q
I
KRNTFVGT
P
F
WM
A
P
E
V
I
-----
K
-----
Q
-SAYDSKA
D
I
W
S
LG
I
T
A
I
ELARGEPPHSELH
P
M
K
V
------
L
F
---------
L
I
---PKNNPPTL--E--G--N
Y
S
K
P
L
K
E
F
V
E
A
C
LNKEPSFR
P
T
A
K
E
L
L
K
H
K
F
I
L
RNAK
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
WKAEQSHDDSSSEDSDAETDGQASGGSDSG
D
W
I
F
T
IREKDPKNLENGALQPSDL
D
R
N
K
M
K
DI
P
K
R
P
F
S
Q
C
L
S
T
I
I
S
P
L
F
A
E
L
K
E
K
S
Q
ACGGNLG
S
I
E
E
L
R
G
A
I
Y
L
A
E
EACPGI
S
D
T
M
V
A
Q
L
V
Q
R
L
Q
R
YSLSGGGTSSH
5
PsiBlast_PDB
94.69
98%
-85
- C1 -
3A7H
1
STK24_HUMAN
A:
[12-298]
-----------------------
G
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
E
--
P
-
G
--
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
------
L
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
E
--
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
94.30
98%
-84
- C1 -
3A7J
1
STK24_HUMAN
A:
[13-299]
------------------------
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
E
--
P
-
G
--
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
------
L
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
E
--
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
94.21
98%
-84
- C1 -
3A7I
1
STK24_HUMAN
A:
[13-299]
------------------------
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
E
--
P
-
G
--
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
------
L
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
E
--
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
93.08
98%
-88
- C1 -
3CKX
1
STK24_HUMAN
A:
[5-283]
---------------------------------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
E
--
P
-
G
--
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
------
L
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
E
--
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
90.26
84%
-85
- C1 -
2XIK
2
STK25_HUMAN
A:
[4-293]
--------------------
H
L
R
G
F
A
N
Q
H
S
R
V
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
-
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
K
--
P
-
G
--
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
R
V
------
L
F
---------
L
I
---
P
K
N
S
P
P
T
L
--
E
--
G
--
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
---------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
87.82
88%
-94
- C1 -
4FZD
1
MST4_HUMAN
B:
[4-283]
-------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
R
--
A
-
G
--
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
------
L
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
V
--
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
87.55
88%
-87
- C1 -
4FZA
3
MST4_HUMAN
B:
[4-283]
-------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
R
--
A
-
G
--
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
------
L
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
V
--
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
86.45
88%
-90
- C1 -
4FZF
1
?
B:
[4-283]
-------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
R
--
A
-
G
--
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
------
L
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
V
--
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
85.21
87%
-96
- C1 -
3GGF
1
MST4_HUMAN
A:
[18-298]
---------------------------
I
---
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
R
--
A
-
G
--
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
---------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
------
L
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
V
--
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
85.15
87%
-97
- C1 -
3GGF
1
MST4_HUMAN
B:
[19-298]
-------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
R
--
A
-
G
--
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
----------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
------
L
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
V
--
G
--
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
66.57
45%
-83
- C1 -
3FXZ
1
?
A:
[17-293]
--------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
-
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
T
--
E
-
T
--
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
------
L
Y
---------
L
I
---
A
T
N
G
T
P
E
L
--
Q
NP
E
--
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
-
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
64.74
98%
-43
- C1 -
3A7H
1
STK24_HUMAN
B:
[12-298]
-----------------------
G
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
E
--
P
-
G
--
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
-
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
------
L
F
---------
L
I
---
P
K
N
N
P
P
T
L
--
E
--
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
61.60
44%
-84
- C1 -
2J7T
1
STK10_HUMAN
A:
[13-297]
---------------------------
R
--
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
-------
K
L
W
I
M
I
E
F
C
P
G
G
A
--
V
D
A
I
M
L
E
L
D
-
R
--
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
V
-----
M
C
E
T
M
K
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
------
L
L
---------
K
I
---
A
K
S
D
P
P
T
L
LT
P
--
S
--
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
-
S
N
K
A
L
R
E
L
V
A
E
A
K
A
------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
60.54
38%
-87
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[35-331]
-------------------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
-------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
V
L
K
--
K
A
G
--
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
--
A
---
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
GC--PMA
I
F
E
L
L
D
Y
I
---
V
N
E
P
P
P
K
L
P-
S
--
G
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
59.26
40%
-82
- C1 -
4KS7
2
A:
[20-282]
--------------------------------
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
Q
-
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
G
E
-------
E
L
W
V
L
M
E
F
L
Q
G
G
A
--
L
T
D
I
V
S
--
Q
-
V
--
R
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
K
D
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
-
S
L
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
Q
A
------
M
K
---------
R
L
---
R
D
S
P
P
P
K
L
--
K
NS
H
--
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
L
Q
T
G
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
57.16
45%
-90
- C1 -
4AOT
1
STK10_HUMAN
A:
[16-279]
--------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
-------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
--
D
-
R
--
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
-------------
G
T
P
Y
W
M
A
P
E
V
V
M--------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
------
L
L
---------
K
I
---
A
K
S
D
P
P
T
L
LT
P
--
S
--
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
54.45
39%
-77
* C1 *
4JDI
2
?
A:
[76-334]
-------------------------------------
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
-
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
-------
E
L
W
V
V
M
E
F
L
E
G
G
A
--
L
T
D
I
V
T
--
H
-
T
--
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
-
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
------
M
K
---------
M
I
---
R
D
N
L
P
P
R
L
--
K
--
N
LH
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
53.01
45%
-90
- C1 -
4EQU
2
STK10_HUMAN
A:
[16-279]
--------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
-------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
--
D
-
R
--
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
---------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
------
L
L
---------
K
I
---
A
K
S
D
P
P
T
L
LT
P
--
S
--
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
46.59
30%
-93
- C1 -
1ZY4
1
GCN2_YEAST
A:
[8-290]
-------------------------------------
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
H
--
T
E
E
K
L
S
T
I
L
S
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
L
E
R
R
N
F
VK
K
K
S
T
L
F
I
Q
M
E
Y
C
E
N
G
T
--
L
Y
D
L
I
H
--
S
-
E
NL
N
Q
Q
R
D
E
Y
W
R
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
-
G
I
I
H
R
D
L
K
P
M
N
I
F
I
D
E
S
R
N
V
K
I
G
D
F
G
L
A
K
N
V
H
R
-----------
A
M
Y
V
A
T
E
V
L
-----
D
-----
G
T
G
H
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
--
P
F
S
T
G
M
E
R
V
N
I
------
L
K
---------
K
L
R
SV
S
I
E
F
P
P
D
F
--
D
--
D
--
N
K
M
K
V
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
N
S
G
W
L
P
V
K
----------------------------------------------------------------------------------------------------------------------------------------------------------