@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00089_PROC_H: (2014-08-23 )
MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230-.-.--.......240.......250...-----..--------.---.260.......270..-.....280.......290-.--..---....300.......310.......320.......330.......340.......350.....---..360.......370.....----------.-.-----380.......390--.---...--....400.....--..410.........420.......430.......440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
W
Q
L
T
S
L
L
L
F
V
A
T
WGISGTP
A
P
L
D
S
V
FS
S
S
E
R
A
H
Q
V
L
R
I
R
K
R
A
N
S
F
L
E
E
L
R
H
S
S
L
E
R
E
C
I
E
E
IC
D
F
E
E
A
K
E
I
F
QNV
D
D
T
L
A
F
W
S
KHVDGD
Q
C
L
V
L
PLEH
P
C
A
S
LCCGHG
T
C
IDGIGSFSCDCRSGWEGR
F
C
Q
R
E
V
S
F
L
N
C
SLDNGG
C
T
H
Y
C
L
E
EVGWRRCSCAPGYKL
G
D
D
L
L
QCHPAVKFPCGR
P
W
K
R
M
E
K
K
R
S
H
LKRDTEDQEDQVD
P
R
LIDGKMTRRGDSP
W
Q
V
V
L
L---D-S--KKKLAC
G
A
V
L
IHP
S
W
V
L
T
A
A
H
C
M
-----
D
E
--------
S
---
K
K
L
L
V
R
LG
E
Y
D
L
R
R
W
E
-KWEL
D
L
D
I
K
E
V
F
VHPNYS-K--ST---TDN
D
I
A
L
L
H
LAQPATLSQ
T
I
V
P
I
C
LPDSG
L
A
E
R
E
L
N
QAGQE
T
L
V
T
GWGYHS
S
R
E
K
E
AKRN
R
T
---
F
V
L
N
F
I
KIPVVP
H
N
E
C
S
E
V
M
----------
S
-
N
-----
M
V
SEN
M
L
C
A
GIL---G---DRQ--DACEGDSGG
P
M
V
--
A
S
F--HG
T
W
F
L
V
G
L
V
SWGEGCGLLHNYG
V
Y
T
K
V
S
R
Y
L
D
W
I
H
G
HIRDKEAPQKSWAP
2
PsiBlast_PDB
92.20
100%
-134
- C1 -
3F6U
1
?
H:
[1-240]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
D
G
K
M
T
R
R
G
D
S
P
W
Q
V
V
L
L
---
D
-
S
--
K
K
K
L
A
C
G
A
V
L
I
H
P
S
W
V
L
T
A
A
H
C
M
-----
D
E
--------
S
---
K
K
L
L
V
R
L
G
E
Y
D
L
R
R
W
E
-
K
W
E
L
D
L
D
I
K
E
V
F
V
H
P
N
Y
S
-
K
--
S
T
---
T
D
N
D
I
A
L
L
H
L
A
Q
P
A
T
L
S
Q
T
I
V
P
I
C
L
P
D
S
G
L
A
E
R
E
L
N
Q
A
G
Q
E
T
L
V
T
G
W
G
Y
H
S
S
R
E
K
E
A
K
R
N
R
T
---
F
V
L
N
F
I
K
I
P
V
V
P
H
N
E
C
S
E
V
M
----------
S
-
N
-----
M
V
S
E
N
M
L
C
A
G
I
L
---
G
---
D
R
Q
--
D
A
C
E
G
D
S
G
G
P
M
V
--
A
S
F
--
H
G
T
W
F
L
V
G
L
V
S
W
G
E
G
C
G
L
L
H
N
Y
G
V
Y
T
K
V
S
R
Y
L
D
W
I
H
G
H
I
R
D
----------
34
HHSearch
91.94
100%
-131
- C1 -
1AUT
1
PROC_HUMAN
C:
[1-240]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
D
G
K
M
T
R
R
G
D
S
P
W
Q
V
V
L
L
---
D
-
S
--
K
K
K
L
A
C
G
A
V
L
I
H
P
S
W
V
L
T
A
A
H
C
M
-----
D
E
--------
S
---
K
K
L
L
V
R
L
G
E
Y
D
L
R
R
W
E
-
K
W
E
L
D
L
D
I
K
E
V
F
V
H
P
N
Y
S
-
K
--
S
T
---
T
D
N
D
I
A
L
L
H
L
A
Q
P
A
T
L
S
Q
T
I
V
P
I
C
L
P
D
S
G
L
A
E
R
E
L
N
Q
A
G
Q
E
T
L
V
T
G
W
G
Y
H
S
S
R
E
K
E
A
K
R
N
R
T
---
F
V
L
N
F
I
K
I
P
V
V
P
H
N
E
C
S
E
V
M
----------
S
-
N
-----
M
V
S
E
N
M
L
C
A
G
I
L
---
G
---
D
R
Q
--
D
A
C
E
G
D
S
G
G
P
M
V
--
A
S
F
--
H
G
T
W
F
L
V
G
L
V
S
W
G
E
G
C
G
L
L
H
N
Y
G
V
Y
T
K
V
S
R
Y
L
D
W
I
H
G
H
I
R
D
----------
38
HHSearch
74.23
39%
-124
- C1 -
4JZE
4
?
H:
[1-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
K
V
C
P
K
G
E
C
P
W
Q
V
L
L
L
-----
V
--
N
G
A
Q
L
C
G
G
T
L
I
N
T
I
W
V
V
S
A
A
H
C
F
-----
D
K
--------
I
KNW
R
N
L
I
A
V
L
G
E
H
D
L
S
E
H
D
-
G
D
E
Q
S
R
R
V
A
Q
V
I
I
P
S
T
Y
V
-
P
--
G
T
---
T
N
H
D
I
A
L
L
R
L
H
Q
P
V
V
L
T
D
H
V
V
P
L
C
L
P
E
R
T
F
S
E
R
T
L
A
-
F
V
R
F
S
L
V
S
G
W
G
Q
L
L
D
R
G
A
T
A
--------
L
E
L
M
V
L
N
V
P
R
L
M
T
Q
D
C
L
Q
Q
S
----------
R
-
K
VGDSP
N
I
T
E
Y
M
F
C
A
G
Y
S
---
D
---
G
S
K
--
D
S
C
K
G
D
S
G
G
P
H
A
--
T
H
Y
--
R
G
T
W
Y
L
T
G
I
V
S
W
G
Q
G
C
A
T
V
G
H
F
G
V
Y
T
R
V
S
Q
Y
I
E
W
L
Q
K
L
M
R
S
E
P
R
P
G
-----
46
HHSearch
73.29
41%
-114
- C1 -
3RM2
5
?
H:
[1-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
---
R
K
S
--
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
-----
L
Y
PPWDKNFT
E
---
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
--
E
N
---
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
-
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
------
G
Q
P
---
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
----------
R
-
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
PDE
G
---
K
R
G
--
D
A
C
E
G
D
S
G
G
P
F
V
--
M
K
S
PF
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
---------
37
HHSearch
72.94
41%
-109
- C1 -
3NXP
5
THRB_HUMAN
A:
[162-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
G
R
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
---
R
K
S
--
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
-----
L
Y
PPWD
K
N
F
T
E
---
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
--
E
N
---
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
-
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
W
T
A
N
---
Q
P
---
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
----------
R
-
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
---
P
DEG
K
R
G
--
D
A
C
E
G
D
S
G
G
P
F
V
--
M
K
S
PF
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
---------
42
HHSearch
72.41
39%
-94
- C1 -
2BDY
2
?
A:
[2-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
C
G
L
R
P
L
F
E
K
K
S
-
L
E
D
K
T
E
R
E
L
L
E
S
Y
I
---
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
---
R
K
S
--
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
-----
L
Y
PPWD
K
N
F
T
E
---
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
--
E
N
---
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
A
S
L
L
Q
-
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
------
G
Q
P
---
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
----------
R
-
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
PDE
G
---
K
R
G
--
D
A
C
E
G
D
S
G
G
P
F
V
--
M
K
S
PF
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
----------
19
PsiBlast_PDB
72.24
35%
-119
- C1 -
2J2U
1
A:
[1-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
---
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
-----
Y
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
-----
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
---
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
-
M
T
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
R
Q
S
T
R
--------
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
----------
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
---
T
---
K
Q
E
--
D
A
C
Q
G
D
S
G
G
P
H
V
--
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
-----------
6
PsiBlast_PDB
72.13
35%
-110
- C1 -
1F0S
1
?
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
---
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
-----
Y
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
---
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
-
M
T
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
R
Q
S
T
R
--------
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
----------
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
---
T
---
K
Q
E
--
D
A
C
Q
G
D
S
G
G
P
H
V
--
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
----------
14
PsiBlast_PDB
72.03
35%
-111
- C1 -
1LPZ
1
?
B:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
---
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
-----
Y
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
---
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
-
M
T
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
R
Q
S
T
R
--------
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
----------
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
---
T
---
K
Q
E
--
D
A
C
Q
G
D
S
G
G
P
H
V
--
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
----------
12
PsiBlast_PDB
71.61
35%
-111
- C1 -
1LPG
1
?
B:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
---
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
-----
Y
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
---
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
-
M
T
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
R
Q
S
T
R
--------
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
----------
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
---
T
---
K
Q
E
--
D
A
C
Q
G
D
S
G
G
P
H
V
--
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
----------
13
PsiBlast_PDB
71.53
35%
-107
- C1 -
1LPK
1
?
B:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
---
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
-----
Y
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
---
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
-
M
T
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
R
Q
S
T
R
--------
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
----------
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
---
T
---
K
Q
E
--
D
A
C
Q
G
D
S
G
G
P
H
V
--
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
----------
15
PsiBlast_PDB
71.22
35%
-110
- C1 -
1LQD
1
?
B:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
---
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
-----
Y
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
---
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
-
M
T
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
R
Q
S
T
R
--------
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
----------
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
---
T
---
K
Q
E
--
D
A
C
Q
G
D
S
G
G
P
H
V
--
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
----------
5
PsiBlast_PDB
71.15
35%
-111
- C1 -
1F0R
1
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
---
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
-----
Y
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
---
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
-
M
T
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
R
Q
S
T
R
--------
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
----------
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
---
T
---
K
Q
E
--
D
A
C
Q
G
D
S
G
G
P
H
V
--
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
----------
18
PsiBlast_PDB
70.95
35%
-108
- C1 -
2CJI
1
?
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
---
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
-----
Y
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
---
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
-
M
T
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
R
Q
S
T
R
--------
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
----------
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
---
T
---
K
Q
E
--
D
A
C
Q
G
D
S
G
G
P
H
V
--
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
----------
11
PsiBlast_PDB
70.95
35%
-112
- C1 -
1NFY
1
?
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
---
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
-----
Y
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
---
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
-
M
T
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
R
Q
S
T
R
--------
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
----------
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
---
T
---
K
Q
E
--
D
A
C
Q
G
D
S
G
G
P
H
V
--
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
----------
4
PsiBlast_PDB
70.86
35%
-110
- C1 -
1EZQ
1
?
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
---
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
-----
Y
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
---
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
-
M
T
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
R
Q
S
T
R
--------
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
----------
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
---
T
---
K
Q
E
--
D
A
C
Q
G
D
S
G
G
P
H
V
--
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
----------
20
PsiBlast_PDB
70.82
35%
-110
- C1 -
2J34
1
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
---
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
-----
Y
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
---
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
-
M
T
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
R
Q
S
T
R
--------
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
----------
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
---
T
---
K
Q
E
--
D
A
C
Q
G
D
S
G
G
P
H
V
--
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
----------
8
PsiBlast_PDB
70.69
35%
-109
- C1 -
1NFU
1
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
---
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
-----
Y
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
---
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
-
M
T
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
R
Q
S
T
R
--------
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
----------
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
---
T
---
K
Q
E
--
D
A
C
Q
G
D
S
G
G
P
H
V
--
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
----------
10
PsiBlast_PDB
70.58
35%
-110
- C1 -
1NFX
1
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
---
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
-----
Y
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
---
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
-
M
T
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
R
Q
S
T
R
--------
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
----------
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
---
T
---
K
Q
E
--
D
A
C
Q
G
D
S
G
G
P
H
V
--
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
----------
39
HHSearch
70.43
36%
-115
- C1 -
2WPH
3
?
S:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
K
P
G
Q
F
P
W
Q
V
V
L
----
N
-
G
--
K
V
D
A
F
C
G
G
S
I
V
N
E
K
W
I
V
T
A
A
H
C
V
-----
E
T
--------
G
---
V
K
I
T
V
V
A
G
E
H
N
I
E
E
T
E
-
H
T
E
Q
K
R
N
V
I
R
I
I
P
H
H
N
F
N
-
A
AI
N
T
---
Y
N
H
D
I
A
L
L
E
L
D
E
P
L
V
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
T
N
I
F
L
K
-
F
G
S
-
G
Y
V
S
G
W
G
R
V
F
H
K
G
R
S
-----
A
---
L
V
L
Q
Y
L
R
V
P
L
V
D
R
A
T
C
L
R
S
T
----------
K
-
F
-----
T
I
T
N
N
M
F
C
A
G
F
H
---
E
---
G
G
R
--
D
S
C
Q
G
D
S
G
G
P
H
V
--
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
M
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
----------
9
PsiBlast_PDB
70.36
35%
-107
- C1 -
1NFW
1
?
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
---
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
-----
Y
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
---
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
L
-
M
T
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
R
Q
S
T
R
--------
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
----------
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
---
T
---
K
Q
E
--
D
A
C
Q
G
D
S
G
G
P
H
V
--
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
T
----------
23
Fugue
69.68
41%
-131
- C1 -
1A0L
1
TRYB2_HUMAN
A:
[1-244]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
A
P
R
S
K
W
P
W
Q
V
S
L
R
V
HG--
P
--
Y
W
M
H
F
C
G
G
S
L
I
H
P
Q
W
V
L
T
A
A
H
C
V
GPDVK
D
L
--------
A
---
A
-
L
R
V
Q
L
R
E
Q
H
L
Y
Y
----
Q
D
Q
L
L
P
V
S
R
I
I
V
H
P
Q
F
Y
-
T
----AQI-
G
A
D
I
A
L
L
E
L
E
E
P
V
K
V
S
S
H
V
H
T
V
T
L
P
P
A
S
---
E
T
F
P
P
-
G
M
P
C
W
V
T
G
W
G
D
V
D
N
D
------
E
R
L
PPP
F
P
L
K
Q
V
K
V
P
I
M
E
N
H
I
C
D
A
-
K
Y
H
LGAYTGDD
V
-
R
-----
I
V
R
D
D
M
L
C
A
G
N
T
----------R
R
D
S
C
Q
G
D
S
G
G
P
L
V
C
K
V
N
----
G
T
W
L
Q
A
G
V
V
S
W
G
E
G
C
A
Q
P
N
R
P
G
I
Y
T
R
V
T
Y
Y
L
D
W
I
H
H
Y
V
P
K
K
---------
55
HHSearch
69.10
36%
-115
- C1 -
3BG8
1
A:
[1-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
---
T
-
T
SP
T
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
-----
Y
G
VES-----
P
---
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
I
K
-
E
D
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
-
M
--
A
E
---
S
G
Y
D
I
A
L
L
K
L
E
T
T
V
N
Y
T
D
S
Q
R
P
I
S
L
P
S
K
G
E
R
---
N
-
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
R
D
K
I
-----
Q
---
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
----------
R
G
H
-----
K
I
T
H
K
M
I
C
A
G
Y
R
---
E
---
G
G
K
--
D
A
C
K
G
D
S
G
G
P
L
S
--
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
----------
47
HHSearch
68.70
34%
-113
- C1 -
1FXY
2
TRY1_HUMAN
A:
[1-227]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Y
N
C
K
D
G
E
V
P
W
Q
A
L
L
I
---
N
-
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
-----
Y
Q
--------
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
-
K
--
E
T
---
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
S
L
P
T
A
P
P
------
A
T
G
T
K
C
L
I
S
G
W
G
N
T
A
S
S
G
A
----
D
Y
P
---
D
E
L
Q
C
L
D
A
P
V
L
S
Q
A
K
C
E
A
S
Y
----------
P
-
G
-----
K
I
T
S
N
M
F
C
V
G
F
L
---
E
---
G
G
K
--
D
S
C
Q
G
D
S
G
G
P
V
V
--
C
----
N
G
--
Q
L
Q
G
V
V
S
W
G
D
G
C
A
Q
K
N
K
P
G
V
Y
T
K
V
Y
N
Y
V
K
W
I
K
N
T
I
A
A
N
---------