@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00089_UROK_R: (2014-08-24 )
MRVWLASLFLCALVANSEGGSELEASDESNCGCQNGGVCVSYKYFSSIRRCSCPKKFKGEHCEIDTSKTCYHGNGQSYRGKANTDTKGRPCLAWNSPAVLQQTYNAHRSDALSLGLGKHNYCRNPDNQRRPWCYVQIGLKQFVQECMVQDCSLSKKPSSTVDQQGFQCGQKALRPRFKIVGGEFTVVENQPWFAAIYLKNKGGSPPSFKCGGSLISPCWVASATHCFVNQPKKEEYVVYLGQSKRNSYNPGEMKFEVEQLILHEDFSDETLAFHNDIALLKIRTSTGQCAQPSRTIQTICLPPRFGDAPFGSDCEITGFGQESATDYFYPKDLKMSVVKIISHEQCKQPHYYGSEINYKMLCAADPEWKTDSCSGDSGGPLICNIDGRPTLSGIVSWGSGCAEKNKPGVYTRVSYFLNWIQSHIGEENGLAF
Atome Classification :
(57 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250---.........260.......270.......280.......290.......300....---...-310.......320.......330.......340.......350---.......360.......370.......380...--....390......--.400.......410.......420.......430
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
V
W
L
A
S
L
F
L
C
A
L
V
ANSEGGSELEASDESNCGCQNG
G
V
C
V
S
Y
K
Y
F
S
S
I
R
RCSCPKKFKGEHCEIDTSK
T
C
YHGNGQSYRGKANTDTKGR
P
C
LAWNS
P
A
V
L
Q
Q
T
Y
N
AHRSDA
L
S
LGLGKHNYCRNPDNQRR
P
W
C
Y
V
Q
I
G
L
K
Q
F
V
Q
E
C
M
V
QDCSLSKKPSST
V
D
Q
Q
G
F
Q
C
G
Q
K
ALRP
R
F
K
I
VG
G
E
F
T
V
VENQP
W
F
A
A
I
Y
L
KNKGGSPPSFKCGGSLI
S
P
C
W
VASA
T
H
CFVNQPKKE
E
Y
V
V
Y
LGQSKRNSYNP-----
G
E
M
K
F
E
V
E
Q
L
I
L
HEDFSDE
T
L
A
FHN
D
I
A
L
L
K
I
RTSTGQCAQPS
R
T
I
Q
T
I
C
LPPRFG---DAP-FGSDC
E
I
T
GFGQESATDYFYPK
D
L
K
M
S
V
V
K
I
I
S
H
E
Q
CKQPHYY---GSEI
N
Y
K
M
L
CAADPEWKTDSCSGDSGG
P
L
I
C
NI--DGRP
T
L
S
G
I
V
S
WG--SGCAEKNKP
G
V
Y
T
R
V
S
Y
F
L
N
W
I
Q
S
HIGEENGLAF
2
PsiBlast_PDB
88.72
71%
-105
- C2 -
1SC8
1
?
U:
[16-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
72
HHSearch
88.14
71%
-105
* C2 *
3MHW
1
?
U:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
-
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
-
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
4
PsiBlast_PDB
87.93
71%
-104
- C2 -
1VJA
1
?
U:
[16-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
53
PsiBlast_CBE
87.85
71%
-105
- C2 -
4GLY
3
?
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
8
PsiBlast_PDB
87.80
70%
-107
- C2 -
1GJA
4
?
B:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
--------
40
PsiBlast_CBE
87.68
71%
-104
- C2 -
4FUE
5
UROK_HUMAN
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
6
PsiBlast_PDB
87.66
70%
-106
- C2 -
1GJ7
4
?
B:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
3
PsiBlast_PDB
87.59
71%
-106
- C2 -
1VJ9
1
?
U:
[16-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
------
51
PsiBlast_CBE
87.57
71%
-103
- C2 -
4JK6
3
?
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
11
PsiBlast_PDB
87.49
70%
-105
- C2 -
1C5W
2
?
B:
[1-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
E
-----
15
PsiBlast_PDB
87.42
70%
-106
- C2 -
1GJ9
4
?
B:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
49
PsiBlast_CBE
87.38
71%
-103
- C2 -
4MNW
7
?
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
20
PsiBlast_PDB
87.25
70%
-106
- C2 -
1O5B
5
?
B:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
A
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
--------
9
PsiBlast_PDB
87.23
70%
-103
- C2 -
1GJB
4
?
B:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
12
PsiBlast_PDB
87.20
70%
-106
- C2 -
1C5X
2
?
B:
[1-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
E
-----
13
PsiBlast_PDB
87.04
70%
-106
- C2 -
1C5Y
2
?
B:
[1-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
E
-----
21
PsiBlast_CBE
87.03
71%
-108
- C2 -
3IG6
3
?
D:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
---
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
33
PsiBlast_CBE
87.02
71%
-104
- C2 -
1OWH
1
UROK_HUMAN
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
36
PsiBlast_CBE
86.94
71%
-101
- C2 -
4FUJ
5
?
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
19
PsiBlast_PDB
86.82
70%
-103
- C2 -
1O5A
3
?
B:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
A
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
48
PsiBlast_CBE
86.72
71%
-100
- C2 -
4MNX
2
?
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
41
PsiBlast_CBE
86.71
71%
-101
- C2 -
4FUD
4
?
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
16
PsiBlast_PDB
86.70
70%
-106
- C2 -
1GJD
4
?
B:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
--------
42
PsiBlast_CBE
86.66
71%
-101
- C2 -
4FUB
9
UROK_HUMAN
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
34
PsiBlast_CBE
86.59
71%
-104
- C2 -
1OWE
1
?
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
43
PsiBlast_CBE
86.54
71%
-100
- C2 -
4FU8
2
UROK_HUMAN
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
29
PsiBlast_CBE
86.45
71%
-103
- C2 -
1OWI
1
?
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
50
PsiBlast_CBE
86.39
71%
-102
- C2 -
4MNV
2
?
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
5
PsiBlast_PDB
86.35
71%
-103
- C2 -
3IG6
3
?
B:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
--------
38
PsiBlast_CBE
86.24
71%
-101
- C2 -
4FUG
3
?
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
32
PsiBlast_CBE
86.24
71%
-99
- C2 -
1SQA
1
?
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
25
PsiBlast_CBE
86.17
71%
-102
- C2 -
1U6Q
1
?
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
39
PsiBlast_CBE
86.16
71%
-101
- C2 -
4FUF
6
UROK_HUMAN
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
52
PsiBlast_CBE
86.15
71%
-101
- C2 -
4JK5
3
?
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
44
PsiBlast_CBE
86.15
71%
-100
- C2 -
4FU7
1
UROK_HUMAN
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
17
PsiBlast_PDB
86.12
70%
-103
- C2 -
1GJC
4
?
B:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
37
PsiBlast_CBE
86.01
71%
-101
- C2 -
4FUI
6
?
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
35
PsiBlast_CBE
85.88
71%
-99
- C2 -
3MWI
1
?
U:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
10
PsiBlast_PDB
85.85
70%
-103
- C2 -
1O3P
4
?
B:
[1-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
-------
14
PsiBlast_PDB
85.77
70%
-109
- C2 -
1C5Z
2
?
B:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
--------
46
PsiBlast_CBE
85.76
71%
-100
- C2 -
4MNY
3
?
B:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
22
PsiBlast_CBE
85.70
71%
-102
- C2 -
1GI9
4
?
B:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
30
PsiBlast_CBE
85.69
71%
-99
- C2 -
1OWD
1
UROK_HUMAN
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
47
PsiBlast_CBE
85.61
71%
-102
- C2 -
4MNY
4
?
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
A
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
7
PsiBlast_PDB
85.55
70%
-102
- C2 -
1GJ8
4
?
B:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
--------
23
PsiBlast_CBE
85.46
71%
-102
- C2 -
1GI8
4
?
B:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
31
PsiBlast_CBE
85.26
71%
-100
- C2 -
1SQO
1
UROK_HUMAN
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
Q
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
24
PsiBlast_CBE
84.45
71%
-102
- C2 -
1GI7
4
?
B:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
A
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
26
PsiBlast_CBE
84.43
71%
-100
- C2 -
1SQT
1
UROK_HUMAN
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
18
PsiBlast_PDB
83.87
70%
-99
- C2 -
1LMW
2
?
B:
[1-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
E
E
-----
28
PsiBlast_CBE
83.80
71%
-100
- C2 -
1OWJ
1
UROK_HUMAN
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
27
PsiBlast_CBE
83.63
71%
-97
- C2 -
1OWK
1
?
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
G
S
V
-
T
Y
V
C
G
G
S
L
M
S
P
C
W
V
I
S
A
T
H
C
F
I
D
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
-----
G
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
D
T
L
A
H
H
N
D
I
A
L
L
K
I
R
S
K
E
G
R
C
A
Q
P
S
R
T
I
Q
T
I
C
L
P
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
Y
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
---
G
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
---------
93
HHSearch
66.88
35%
-96
- C2 -
1BRU
1
CEL2A_PIG
P:
[1-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
R
P
N
S
W
P
W
Q
V
S
L
Q
Y
D
S
S
G
--
Q
W
R
H
T
C
G
G
T
L
V
D
Q
S
W
V
L
T
A
A
H
C
I
S
S
---
S
R
T
Y
R
V
V
L
G
R
H
S
L
S
T
N
E
P
-----
G
S
L
A
V
K
V
S
K
L
V
V
H
Q
D
W
N
S
N
Q
L
S
N
G
N
D
I
A
L
L
K
L
A
S
P
----
V
S
L
T
D
K
I
Q
L
G
C
L
P
A
A
G
T
---
I
L
P
-
N
N
Y
V
C
Y
V
T
G
W
G
R
L
Q
T
N
G
-
A
S
P
D
I
L
Q
Q
G
Q
L
L
V
V
D
Y
A
T
C
S
K
P
G
W
W
---
G
S
T
V
K
T
N
M
I
C
A
G
G
D
-
G
I
I
S
S
C
N
G
D
S
G
G
P
L
N
C
Q
G
A-
N
G
Q
W
Q
V
H
G
I
V
S
F
G
SS
L
G
C
N
Y
Y
H
K
P
S
V
F
T
R
V
S
N
Y
I
D
W
I
N
S
V
I
A
N
------
85
HHSearch
66.51
35%
-97
- C2 -
2OQ5
1
TM11E_HUMAN
A:
[1-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
E
V
E
E
G
E
W
P
W
Q
A
S
L
Q
W
D
G
------
S
H
R
C
G
A
T
L
I
N
A
T
W
L
V
S
A
A
H
C
F
T
T
Y
K
N
P
A
R
W
T
A
S
F
G
V
T
I
----
K
P
-----
S
K
M
K
R
G
L
R
R
I
I
V
H
E
K
Y
K
H
P
S
--
H
D
Y
D
I
S
L
A
E
L
S
S
P
----
V
P
Y
T
N
A
V
H
R
V
C
L
P
D
A
S
Y
---
E
F
Q
-
P
G
D
V
M
F
V
T
G
F
G
A
L
K
N
D
G
-
Y
S
Q
N
H
L
R
Q
A
Q
V
T
L
I
D
A
T
T
C
N
E
P
Q
A
Y
---
N
D
A
I
T
P
R
M
L
C
A
G
S
L
E
G
K
T
D
A
C
Q
G
D
S
G
G
P
L
V
S
S
D
A-
R
D
I
W
Y
L
A
G
I
V
S
W
G
--
D
E
C
A
K
P
N
K
P
G
V
Y
T
R
V
T
A
L
R
D
W
I
T
S
K
T
G
-------
97
HHSearch
64.67
33%
-81
- C2 -
1FIW
4
ACRO_SHEEP
A:
[1-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
Q
D
A
A
H
G
A
W
P
W
M
V
S
L
Q
I
F
T
Y
H
N
N
R
R
Y
H
V
C
G
G
S
L
L
N
S
Q
W
L
L
T
A
A
H
C
F
R
I
K
K
K
V
T
D
W
R
L
I
F
G
A
K
E
V
E
W
G
T
N
K
P
V
K
P
P
L
Q
E
R
Y
V
E
K
I
I
I
H
E
K
Y
S
A
S
S
--
E
A
N
D
I
A
L
M
K
I
T
P
P
V
----
T
C
G
H
F
I
G
P
G
C
L
P
Q
F
R
A
---
G
P
P
R
V
P
Q
T
C
W
V
A
G
W
G
F
L
Q
E
N
A
R
R
T
S
P
M
L
Q
E
A
R
V
D
L
I
D
L
G
L
C
N
S
T
R
W
Y
---
N
G
R
I
R
S
T
N
V
C
A
G
Y
P
E
G
K
I
D
T
C
Q
G
D
S
G
G
P
L
M
C
K
D
SA
E
N
S
Y
V
V
V
G
I
T
S
W
G
--
V
G
C
A
R
A
K
R
P
G
V
Y
T
S
T
W
S
Y
L
N
W
I
A
S
K
I
G
S
------
83
HHSearch
62.01
33%
-87
- C2 -
3BG8
1
A:
[1-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
---
T
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
I
K
E
-----
D
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
V
----
N
Y
T
D
S
Q
R
P
I
S
L
P
S
K
G
E
---
R
N
V
-
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
R
D
-
K
I
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
-
R
Y
R
---
G
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
--
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
------
94
HHSearch
61.70
32%
-85
- C2 -
4JZE
4
?
H:
[1-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
K
V
C
P
K
G
E
C
P
W
Q
V
L
L
L
V
N
G
------
A
Q
L
C
G
G
T
L
I
N
T
I
W
V
V
S
A
A
H
C
F
D
K
I
K
N
W
R
N
L
I
A
V
L
G
E
H
D
L
S
E
H
D
G
-----
D
E
Q
S
R
R
V
A
Q
V
I
I
P
S
T
Y
V
P
G
T
--
T
N
H
D
I
A
L
L
R
L
H
Q
P
V
----
V
L
T
D
H
V
V
P
L
C
L
P
E
R
T
F
SER
T
L
A
-
F
V
R
F
S
L
V
S
G
W
G
Q
L
L
D
R
G
-
A
T
A
L
E
L
M
V
L
N
V
P
R
L
M
T
Q
D
C
L
Q
Q
S
R
K
VGD
S
P
N
I
T
E
Y
M
F
C
A
G
Y
S
D
G
S
K
D
S
C
K
G
D
S
G
G
P
H
A
T
H
Y
--
R
G
T
W
Y
L
T
G
I
V
S
W
G
--
Q
G
C
A
T
V
G
H
F
G
V
Y
T
R
V
S
Q
Y
I
E
W
L
Q
K
L
M
R
S
E
P
----