@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00303_TYSY_M: (2014-09-04 )
MTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELLWFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFEYTYEDIVVKNYDPHPAIKAPVAV
Atome Classification :
(39 SA)
.........10........20........30-........40-........50........60........70........80...------------.------------.--------------------------------------------------...90........100--.------------------------.--------..--------...110.......120.......130.......140.......150--..---..---...160.......170.......180.......190.......200.......210.......220.......230....-....240-------..---......250.......260.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
P
Y
E
D
L
L
R
F
V
L
ETGTPKSDRTGT
G
T
R
S
L
F
G
-
Q
Q
M
R
Y
DLSAG-FPL
L
T
TKK
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
RGDSNIG
W
L
H
EHGV
T
I
W
D
E
W
A------------S------------D--------------------------------------------------TGELGPIY
G
V
QWRSWP--A------------------------P--------S
G
--------
E
H
I
D
Q
I
S
A
A
L
D
L
L
RTDPDS
R
R
I
I
V
S
AWNVG
E
I
E
RMALP
P
C
H
A
F
F
Q
F
--
Y
V---AD---G
R
L
S
C
Q
L
Y
QRSA
D
L
F
L
GV
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
AGLSV
G
E
F
I
W
TGG
D
C
H
I
YD
N
H
V
E
Q
V
R
L
Q
LSREPRPYP
K
L
L
-LADR-
D
S
I
F
E
Y
--------
T
Y
---
E
D
I
V
VKNYDPHPAIKAPVAV
55
HHSearch
96.92
100%
-136
- C8 -
4FQS
3
TYSY_MYCTU
A:
[1-263]
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
D
R
T
G
T
G
T
R
S
L
F
G
-
Q
Q
M
R
Y
D
L
S
A
G
-
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
------------
S
------------
D
--------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
--
A
------------------------
P
--------
S
G
--------
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
-
L
A
D
R
-
D
S
I
F
E
Y
--------
T
Y
---
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
V
A
V
27
PsiBlast_CBE
96.47
100%
-135
- C8 -
4FQS
3
TYSY_MYCTU
B:
[1-263]
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
D
R
T
G
T
G
T
R
S
L
F
G
-
Q
Q
M
R
Y
D
L
S
A
G
-
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
------------
S
------------
D
--------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
--
A
------------------------
P
--------
S
G
--------
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
-
L
A
D
R
-
D
S
I
F
E
Y
--------
T
Y
---
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
V
A
V
35
PsiBlast_CBE
96.10
100%
-138
- C8 -
4FOG
3
TYSY_MYCTU
D:
[1-263]
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
D
R
T
G
T
G
T
R
S
L
F
G
-
Q
Q
M
R
Y
D
L
S
A
G
-
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
------------
S
------------
D
--------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
--
A
------------------------
P
--------
S
G
--------
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
-
L
A
D
R
-
D
S
I
F
E
Y
--------
T
Y
---
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
V
A
V
22
PsiBlast_CBE
96.09
100%
-139
- C8 -
4FOA
2
TYSY_MYCTU
C:
[2-261]
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
D
R
T
G
T
G
T
R
S
L
F
G
-
Q
Q
M
R
Y
D
L
S
A
G
-
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
------------
S
------------
D
--------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
--
A
------------------------
P
--------
S
G
--------
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
-
L
A
D
R
-
D
S
I
F
E
Y
--------
T
Y
---
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
---
24
PsiBlast_CBE
95.90
100%
-141
- C8 -
3QJ7
3
TYSY_MYCTU
D:
[2-264]
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
---
G
T
G
T
R
S
L
F
G
-
Q
Q
M
R
Y
D
L
S
A
G
-
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
------------
S
------------
D
--------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
--
A
------------------------
P
--------
S
G
--------
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
-
L
A
D
R
-
D
S
I
F
E
Y
--------
T
Y
---
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
V
A
V
2
PsiBlast_PDB
95.85
100%
-139
- C8 -
4FOA
2
TYSY_MYCTU
A:
[2-261]
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
D
R
T
G
T
G
T
R
S
L
F
G
-
Q
Q
M
R
Y
D
L
S
A
G
-
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
------------
S
------------
D
--------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
--
A
------------------------
P
--------
S
G
--------
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
-
L
A
D
R
-
D
S
I
F
E
Y
--------
T
Y
---
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
---
21
PsiBlast_CBE
95.75
100%
-139
- C8 -
4FOA
2
TYSY_MYCTU
D:
[2-262]
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
D
R
T
G
T
G
T
R
S
L
F
G
-
Q
Q
M
R
Y
D
L
S
A
G
-
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
------------
S
------------
D
--------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
--
A
------------------------
P
--------
S
G
--------
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
-
L
A
D
R
-
D
S
I
F
E
Y
--------
T
Y
---
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
V
--
25
PsiBlast_CBE
95.67
100%
-141
- C8 -
3QJ7
2
TYSY_MYCTU
C:
[2-262]
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
D
--
G
T
G
T
R
S
L
F
G
-
Q
Q
M
R
Y
D
L
S
A
G
-
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
------------
S
------------
D
--------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
--
A
------------------------
P
--------
S
G
--------
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
-
L
A
D
R
-
D
S
I
F
E
Y
--------
T
Y
---
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
V
--
3
PsiBlast_PDB
95.59
100%
-141
- C8 -
4FOG
3
TYSY_MYCTU
A:
[1-260]
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
D
R
T
G
T
G
T
R
S
L
F
G
-
Q
Q
M
R
Y
D
L
S
A
G
-
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
------------
S
------------
D
--------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
--
A
------------------------
P
--------
S
G
--------
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
-
L
A
D
R
-
D
S
I
F
E
Y
--------
T
Y
---
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
---
26
PsiBlast_CBE
95.52
100%
-142
- C8 -
3QJ7
2
TYSY_MYCTU
B:
[2-261]
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
---
G
T
G
T
R
S
L
F
G
-
Q
Q
M
R
Y
D
L
S
A
G
-
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
------------
S
------------
D
--------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
--
A
------------------------
P
--------
S
G
--------
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
-
L
A
D
R
-
D
S
I
F
E
Y
--------
T
Y
---
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
---
36
PsiBlast_CBE
95.40
100%
-134
- C8 -
4FOG
3
TYSY_MYCTU
C:
[1-262]
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
D
R
T
G
T
G
T
R
S
L
F
G
-
Q
Q
M
R
Y
D
L
S
A
G
-
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
------------
S
------------
D
--------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
--
A
------------------------
P
--------
S
G
--------
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
-
L
A
D
R
-
D
S
I
F
E
Y
--------
T
Y
---
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
V
A
-
37
PsiBlast_CBE
95.28
100%
-141
- C8 -
4FOG
2
TYSY_MYCTU
B:
[1-260]
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
D
--
G
T
G
T
R
S
L
F
G
-
Q
Q
M
R
Y
D
L
S
A
G
-
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
------------
S
------------
D
--------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
--
A
------------------------
P
--------
S
G
--------
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
-
L
A
D
R
-
D
S
I
F
E
Y
--------
T
Y
---
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
---
1
PsiBlast_PDB
95.26
100%
-138
- C8 -
3QJ7
3
TYSY_MYCTU
A:
[2-261]
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
D
R
T
G
T
G
T
R
S
L
F
G
-
Q
Q
M
R
Y
D
L
S
A
G
-
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
------------
S
------------
D
--------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
--
A
------------------------
P
--------
S
G
--------
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
-
L
A
D
R
-
D
S
I
F
E
Y
--------
T
Y
---
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
---
23
PsiBlast_CBE
95.01
100%
-141
- C8 -
4FOA
2
TYSY_MYCTU
B:
[2-262]
M
T
P
Y
E
D
L
L
R
F
V
L
E
T
G
T
P
K
S
D
---
T
G
T
R
S
L
F
G
-
Q
Q
M
R
Y
D
L
S
A
G
-
F
P
L
L
T
T
K
K
V
H
F
K
S
V
A
Y
E
L
L
W
F
L
R
G
D
S
N
I
G
W
L
H
E
H
G
V
T
I
W
D
E
W
A
------------
S
------------
D
--------------------------------------------------
T
G
E
L
G
P
I
Y
G
V
Q
W
R
S
W
P
--
A
------------------------
P
--------
S
G
--------
E
H
I
D
Q
I
S
A
A
L
D
L
L
R
T
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
I
E
R
M
A
L
P
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
R
L
S
C
Q
L
Y
Q
R
S
A
D
L
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
M
A
A
Q
A
G
L
S
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
V
E
Q
V
R
L
Q
L
S
R
E
P
R
P
Y
P
K
L
L
-
L
A
D
R
-
D
S
I
F
E
Y
--------
T
Y
---
E
D
I
V
V
K
N
Y
D
P
H
P
A
I
K
A
P
V
--
41
PsiBlast_CBE
86.44
73%
-141
- C8 -
4H0U
2
TYSY_CORGL
A:
[5-264]
-
T
P
Y
E
D
L
L
R
K
I
A
E
E
G
S
H
K
D
----
T
G
T
T
S
L
F
G
-
Q
Q
I
R
F
D
L
N
E
G
-
F
P
L
L
T
T
K
K
V
H
F
H
S
V
V
G
E
L
L
W
F
L
Q
G
D
S
N
V
K
W
L
Q
D
N
N
I
R
I
W
N
E
W
A
------------
D
------------
E
--------------------------------------------------
D
G
E
L
G
P
V
Y
G
V
Q
W
R
S
W
P
--
T
------------------------
P
--------
D
G
--------
R
H
I
D
Q
I
S
G
A
L
E
T
L
R
N
N
P
D
S
R
R
N
I
V
S
A
W
N
V
S
E
L
E
N
M
A
L
P
P
C
H
L
L
F
Q
L
--
Y
V
---
A
D
---
G
K
L
S
C
Q
L
Y
Q
R
S
A
D
M
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
F
A
Q
Q
A
G
L
E
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
K
E
Q
V
A
E
Q
L
S
R
E
A
R
P
Y
P
T
L
E
-
L
N
K
A
-
A
S
M
F
E
Y
--------
S
F
---
D
D
I
T
V
S
G
Y
D
P
H
P
L
I
R
G
K
V
--
38
PsiBlast_CBE
86.24
73%
-143
- C8 -
4H0U
2
TYSY_CORGL
D:
[5-260]
-
T
P
Y
E
D
L
L
R
K
I
A
E
E
G
S
H
K
D
-----
G
T
T
S
L
F
G
-
Q
Q
I
R
F
D
L
N
E
G
-
F
P
L
L
T
T
K
K
V
H
F
H
S
V
V
G
E
L
L
W
F
L
Q
G
D
S
N
V
K
W
L
Q
D
N
N
I
R
I
W
N
E
W
A
------------
D
------------
E
--------------------------------------------------
D
G
E
L
G
P
V
Y
G
V
Q
W
R
S
W
P
--
T
------------------------
P
--------
D
G
--------
R
H
I
D
Q
I
S
G
A
L
E
T
L
R
N
N
P
D
S
R
R
N
I
V
S
A
W
N
V
S
E
L
E
N
M
A
L
P
P
C
H
L
L
F
Q
L
--
Y
V
---
A
D
---
G
K
L
S
C
Q
L
Y
Q
R
S
A
D
M
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
F
A
Q
Q
A
G
L
E
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
K
E
Q
V
A
E
Q
L
S
R
E
A
R
P
Y
P
T
L
E
-
L
N
K
A
-
A
S
M
F
E
Y
--------
S
F
---
D
D
I
T
V
S
G
Y
D
P
H
P
L
I
------
40
PsiBlast_CBE
85.60
73%
-139
- C8 -
4H0U
2
TYSY_CORGL
B:
[5-261]
-
T
P
Y
E
D
L
L
R
K
I
A
E
E
G
S
H
K
D
---
G
T
G
T
T
S
L
F
G
-
Q
Q
I
R
F
D
L
N
E
G
-
F
P
L
L
T
T
K
K
V
H
F
H
S
V
V
G
E
L
L
W
F
L
Q
G
D
S
N
V
K
W
L
Q
D
N
N
I
R
I
W
N
E
W
A
------------
D
------------
E
--------------------------------------------------
D
G
E
L
G
P
V
Y
G
V
Q
W
R
S
W
P
--
T
------------------------
P
--------
D
G
--------
R
H
I
D
Q
I
S
G
A
L
E
T
L
R
N
N
P
D
S
R
R
N
I
V
S
A
W
N
V
S
E
L
E
N
M
A
L
P
P
C
H
L
L
F
Q
L
--
Y
V
---
A
D
---
G
K
L
S
C
Q
L
Y
Q
R
S
A
D
M
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
F
A
Q
Q
A
G
L
E
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
K
E
Q
V
A
E
Q
L
S
R
E
A
R
P
Y
P
T
L
E
-
L
N
K
A
-
A
S
M
F
E
Y
--------
S
F
---
D
D
I
T
V
S
G
Y
D
P
H
P
L
I
R
-----
39
PsiBlast_CBE
84.21
73%
-137
- C8 -
4H0U
2
TYSY_CORGL
C:
[5-260]
-
T
P
Y
E
D
L
L
R
K
I
A
E
E
G
S
H
K
------
G
T
T
S
L
F
G
-
Q
Q
I
R
F
D
L
N
E
G
-
F
P
L
L
T
T
K
K
V
H
F
H
S
V
V
G
E
L
L
W
F
L
Q
G
D
S
N
V
K
W
L
Q
D
N
N
I
R
I
W
N
E
W
A
------------
D
------------
E
--------------------------------------------------
D
G
E
L
G
P
V
Y
G
V
Q
W
R
S
W
P
--
T
------------------------
P
--------
D
G
--------
R
H
I
D
Q
I
S
G
A
L
E
T
L
R
N
N
P
D
S
R
R
N
I
V
S
A
W
N
V
S
E
L
E
N
M
A
L
P
P
C
H
L
L
F
Q
L
--
Y
V
---
A
D
---
G
K
L
S
C
Q
L
Y
Q
R
S
A
D
M
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
M
F
A
Q
Q
A
G
L
E
V
G
E
F
I
W
T
G
G
D
C
H
I
Y
D
N
H
K
E
Q
V
A
E
Q
L
S
R
E
A
R
P
Y
P
T
L
E
-
L
N
K
A
-
A
S
M
F
E
Y
--------
S
F
---
D
D
I
T
V
S
G
Y
D
P
H
P
L
I
------
20
PsiBlast_PDB
84.18
66%
-127
- C8 -
2BBQ
3
TYSY_ECOLI
A:
[1-264]
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
-
H
Q
M
R
F
N
L
Q
D
G
-
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
------------
D
------------
E
--------------------------------------------------
N
G
D
L
G
P
V
Y
G
K
Q
W
R
A
W
P
--
T
------------------------
P
--------
D
G
--------
R
H
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
-
I
K
R
K
P
E
S
I
F
D
Y
--------
R
F
---
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
52
HHSearch
80.80
58%
-132
- C8 -
4DQ1
2
TYSY_STAAM
A:
[9-317]
D
A
A
Y
H
S
L
C
E
E
V
L
E
I
G
N
T
R
N
D
R
T
N
T
G
T
I
S
K
F
G
-
H
Q
L
R
F
D
L
S
K
G
-
F
P
L
L
T
T
K
K
V
S
F
K
L
V
A
T
E
L
L
W
F
I
K
G
D
T
N
I
Q
Y
L
L
K
Y
N
N
N
I
W
N
E
W
A
------------
F
------------
E
N
Y
I
K
SDEYNGPDMTDF
G
H
R
A
L
S
D
P
E
F
N
E
Q
Y
K
E
Q
M
K
Q
F
K
Q
R
I
L
E
D
D
T
F
A
K
Q
F
G
D
L
G
N
V
Y
G
K
Q
W
R
D
W
V
--
D
------------------------
K
--------
D
G
--------
N
H
F
D
Q
L
K
T
V
I
E
Q
I
K
H
N
P
D
S
R
R
H
I
V
S
A
W
N
P
T
E
I
D
T
M
A
L
P
P
C
H
T
M
F
Q
F
--
Y
V
---
Q
D
---
G
K
L
S
C
Q
L
Y
Q
R
S
A
D
I
F
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
H
L
I
A
K
E
C
G
L
E
V
G
E
F
V
H
T
F
G
D
A
H
I
Y
S
N
H
I
D
A
I
Q
T
Q
L
A
R
E
S
F
N
P
P
T
L
K
-
I
N
S
D
-
K
S
I
F
D
I
--------
N
Y
---
E
D
L
E
I
V
D
Y
E
S
H
P
A
I
K
A
----
67
HHSearch
79.88
49%
-132
- C8 -
3NRR
8
?
A:
[232-515]
E
F
Q
Y
L
D
I
L
A
D
V
L
S
H
G
V
L
K
P
N
R
T
G
T
D
A
Y
S
K
F
G
-
Y
Q
M
R
F
D
L
S
R
S
-
F
P
L
L
T
T
K
K
V
A
L
R
S
I
I
E
E
L
L
W
F
I
K
G
S
T
N
G
N
D
L
L
A
K
N
V
R
I
W
E
L
N
G
R
R
D
F
L
D
K
N
GFTD
R
------------
E
--------------------------------------------------
E
H
D
L
G
P
I
Y
G
F
Q
W
R
H
F
G
--
A
EYLDMHAD----------------
Y
--------
T
G
--------
K
G
I
D
Q
L
A
E
I
I
N
R
I
K
T
N
P
N
D
R
R
L
I
V
C
S
W
N
V
S
D
L
K
K
M
A
L
P
P
C
H
C
F
F
Q
F
--
Y
V
---
S
D
---
N
K
L
S
C
M
M
H
Q
R
S
C
D
L
G
L
G
V
P
F
N
I
A
S
Y
S
I
L
T
A
M
V
A
Q
V
C
G
L
G
L
G
E
F
V
H
N
L
A
D
A
H
I
Y
V
D
H
V
D
A
V
T
T
Q
I
A
R
I
P
H
P
F
P
R
L
R
-
L
N
P
D
I
R
N
I
E
D
F
--------
T
I
---
D
D
I
V
V
E
D
Y
V
S
H
P
P
I
P
M
A
M
S
A
59
HHSearch
79.51
50%
-133
- C8 -
4G9U
7
?
A:
[36-313]
E
L
N
Y
L
N
Q
L
K
D
I
I
D
H
G
V
R
K
N
D
R
T
G
I
G
T
L
S
T
F
G
-
T
Q
S
R
Y
C
L
R
D
D
I
F
P
L
L
T
T
K
R
V
F
W
R
G
V
V
E
E
L
L
W
F
I
S
G
S
T
N
A
K
Q
L
S
E
K
N
V
N
I
W
D
G
N
S
S
R
E
F
L
D
S
R
GLYN
Y
------------
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
--
C
PYSSMTAD----------------
Y
--------
K
G
--------
K
G
Y
D
Q
L
Q
Q
C
I
K
M
I
R
E
E
P
E
S
R
R
I
I
M
T
A
W
N
P
C
D
L
E
K
V
A
L
P
P
C
H
C
F
V
Q
F
--
Y
V
---
A
D
---
G
E
L
S
C
Q
M
Y
Q
R
S
A
D
M
G
L
G
V
P
F
N
I
A
S
Y
S
L
L
T
R
M
I
A
H
I
T
S
L
K
P
G
F
F
I
H
T
I
G
D
A
H
V
Y
L
T
H
V
D
A
L
K
V
Q
M
E
R
K
P
R
P
F
P
K
L
K
-
I
L
R
N
V
E
N
I
D
D
F
--------
R
A
---
E
D
F
E
L
I
N
Y
K
P
Y
P
K
-------
72
HHSearch
79.39
45%
-131
- C8 -
3QG2
2
?
A:
[325-608]
E
Y
Q
Y
L
N
I
I
Y
D
I
M
M
N
G
N
K
Q
S
D
R
T
G
V
G
V
L
S
K
F
G
-
Y
I
M
K
F
D
L
S
Q
Y
-
F
P
L
L
T
T
K
K
L
F
L
R
G
I
I
E
E
L
L
W
F
I
R
G
E
T
N
G
N
T
L
L
N
K
N
V
R
I
W
E
A
N
G
T
R
E
F
L
D
N
R
KLFH
R
------------
E
--------------------------------------------------
V
N
D
L
G
P
I
Y
G
F
Q
W
R
H
F
G
--
A
EYTNMYDN----------------
Y
--------
E
N
--------
K
G
V
D
Q
L
K
N
I
I
N
L
I
K
N
D
P
T
S
R
R
I
L
L
C
A
W
N
V
K
D
L
D
Q
M
A
L
P
P
C
H
I
L
C
Q
F
--
Y
V
---
F
D
---
G
K
L
S
C
I
M
Y
Q
R
S
C
D
L
G
L
G
V
P
F
N
I
A
S
Y
S
I
F
T
H
M
I
A
Q
V
C
N
L
Q
P
A
Q
F
I
H
V
L
G
N
A
H
V
Y
N
N
H
I
D
S
L
K
I
Q
L
N
R
I
P
Y
P
F
P
T
L
K
-
L
N
P
D
I
K
N
I
E
D
F
--------
T
I
---
S
D
F
T
I
Q
N
Y
V
H
H
E
K
I
S
M
D
M
A
A
58
HHSearch
79.28
53%
-124
* C8 *
4EZ8
4
TYSY_MOUSE
A:
[24-307]
E
L
Q
Y
L
R
Q
V
E
H
I
L
R
C
G
F
K
K
E
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
R
I
W
D
A
N
G
------------
S
R
D
F
L
D
S
L
GFSAR
Q
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
--
A
EYKDMDSD----------------
Y
--------
S
G
--------
Q
G
V
D
Q
L
Q
K
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
K
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
G
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
Q
P
G
D
F
V
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
K
-
I
L
R
K
V
E
T
I
D
D
F
--------
K
V
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
M
A
V
63
HHSearch
79.19
45%
-129
- C8 -
1J3K
2
?
C:
[45-328]
E
Y
Q
Y
L
N
I
I
Y
D
I
M
M
N
G
N
K
Q
S
D
R
T
G
V
G
V
L
S
K
F
G
-
Y
I
M
K
F
D
L
S
Q
Y
-
F
P
L
L
T
T
K
K
L
F
L
R
G
I
I
E
E
L
L
W
F
I
R
G
E
T
N
G
N
T
L
L
N
K
N
V
R
I
W
E
A
N
G
T
R
E
F
L
D
N
R
KLFH
R
------------
E
--------------------------------------------------
V
N
D
L
G
P
I
Y
G
F
Q
W
R
H
F
G
--
A
EYTNMYDN----------------
Y
--------
E
N
--------
K
G
V
D
Q
L
K
N
I
I
N
L
I
K
N
D
P
T
S
R
R
I
L
L
C
A
W
N
V
K
D
L
D
Q
M
A
L
P
P
C
H
I
L
C
Q
F
--
Y
V
---
F
D
---
G
K
L
S
C
I
M
Y
Q
R
S
C
D
L
G
L
G
V
P
F
N
I
A
S
Y
S
I
F
T
H
M
I
A
Q
V
C
N
L
Q
P
A
Q
F
I
H
V
L
G
N
A
H
V
Y
N
N
H
I
D
S
L
K
I
Q
L
N
R
I
P
Y
P
F
P
T
L
K
-
L
N
P
D
I
K
N
I
E
D
F
--------
T
I
---
S
D
F
T
I
Q
N
Y
V
H
H
E
K
I
S
M
D
M
A
A
65
HHSearch
79.09
53%
-138
- C8 -
1HW4
1
TYSY_HUMAN
A:
[72-352]
E
L
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
------------------------------------------------------------------------------------
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
--
A
E
Y
R
DMESD----------------
Y
--------
S
G
--------
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
-
I
L
R
K
V
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
I
K
M
E
---
8
PsiBlast_PDB
77.93
50%
-126
- C8 -
1I00
3
TYSY_HUMAN
A:
[9-283]
--
Q
Y
L
G
Q
I
Q
H
I
L
R
C
G
V
R
K
D
D
R
T
G
T
G
T
L
S
V
F
G
-
M
Q
A
R
Y
S
L
R
D
E
-
F
P
L
L
T
T
K
R
V
F
W
K
G
V
L
E
E
L
L
W
F
I
K
G
S
T
N
A
K
E
L
S
S
K
G
V
K
I
W
D
A
N
G
------------
S
R
D
F
L
D
S
L
GFSTR
E
--------------------------------------------------
E
G
D
L
G
P
V
Y
G
F
Q
W
R
H
F
G
--
A
------------------------
E
YRDMESDY
S
G
--------
Q
G
V
D
Q
L
Q
R
V
I
D
T
I
K
T
N
P
D
D
R
R
I
I
M
C
A
W
N
P
R
D
L
P
L
M
A
L
P
P
C
H
A
L
C
Q
F
--
Y
V
---
V
N
---
S
E
L
S
C
Q
L
Y
Q
R
S
G
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
Y
M
I
A
H
I
T
G
L
K
P
G
D
F
I
H
T
L
G
D
A
H
I
Y
L
N
H
I
E
P
L
K
I
Q
L
Q
R
E
P
R
P
F
P
K
L
R
I
L
R
K
V
-
E
K
I
D
D
F
--------
K
A
---
E
D
F
Q
I
E
G
Y
N
P
H
P
T
-------
60
HHSearch
77.88
48%
-121
- C8 -
1F28
3
TYSY_PNECA
A:
[6-297]
E
Q
Q
Y
L
N
L
V
Q
Y
I
I
N
H
G
E
D
R
P
D
R
T
G
T
G
T
L
S
V
F
A
P
S
P
L
K
F
S
L
R
N
K
T
F
P
L
L
T
T
K
R
V
F
I
R
G
V
I
E
E
L
L
W
F
I
R
G
E
T
D
S
L
K
L
R
E
K
N
I
H
I
W
D
A
N
G
S
R
E
Y
L
D
S
I
GLTK
R
------------
Q
--------------------------------------------------
E
G
D
L
G
P
I
Y
G
F
Q
W
R
H
F
G
--
A
EYIDCKTN----------------
Y
--------
I
G
--------
Q
G
V
D
Q
L
A
N
I
I
Q
K
I
R
T
S
P
Y
D
R
R
L
I
L
S
A
W
N
P
A
D
L
E
K
M
A
L
P
P
C
H
M
F
C
Q
F
--
Y
V
H
I
P
S
N
NH
R
P
E
L
S
C
Q
L
Y
Q
R
S
C
D
M
G
L
G
V
P
F
N
I
A
S
Y
A
L
L
T
C
M
I
A
H
V
C
D
L
D
P
G
D
F
I
H
V
M
G
D
C
H
I
Y
K
D
H
I
E
A
L
Q
Q
Q
L
T
R
S
P
R
P
F
P
T
L
S
-
L
N
R
S
I
T
D
I
E
D
F
--------
T
L
---
D
D
F
N
I
Q
N
Y
H
P
Y
E
T
I
K
M
K
M
S
I
64
HHSearch
70.35
41%
-121
- C8 -
3V8H
5
?
A:
[5-318]
M
K
Q
Y
L
D
L
V
R
T
I
L
D
T
G
T
W
Q
S
N
--
G
I
R
T
I
G
I
P
G
-
A
M
L
R
F
D
L
Q
Q
G
-
F
P
A
V
T
T
K
K
L
A
F
K
S
A
I
G
E
L
V
G
F
L
R
A
T
R
S
A
A
E
F
R
A
L
G
C
K
V
W
D
A
N
A
------------
N
------------
E
N
A
Q
W
L
A
NPYRRG--------------------------------------
A
D
D
L
G
D
V
Y
G
V
Q
W
R
R
W
P
G
Y
K
V
L
DAHA
D
A
Q
I
A
D
A
T
S
R
G
F
R
I
V
A
R
F
E
--------
E
G
G
A
D
K
V
L
L
H
K
A
I
D
Q
L
R
D
C
L
D
T
I
V
R
D
P
S
S
R
R
I
L
F
H
G
W
N
P
A
V
L
D
E
I
A
L
P
A
C
H
L
L
Y
Q
F
L
P
N
V
---
E
R
---
R
E
I
S
L
C
L
Y
I
R
S
N
D
V
G
L
G
T
P
F
N
L
A
E
G
A
A
L
L
T
L
V
G
R
L
T
G
Y
S
P
R
W
F
T
Y
F
I
G
D
A
H
I
Y
E
N
Q
L
D
M
L
K
Q
Q
L
E
R
E
P
F
E
S
P
R
L
E
-
L
A
E
R
V
P
D
Y
A
K
T
GKYEPQWL
E
R
VEP
S
D
F
T
L
V
G
Y
R
H
H
---------
18
PsiBlast_PDB
48.75
66%
-29
- C8 -
1TRG
2
TYSY_ECOLI
A:
[4-265]
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
-
H
Q
M
R
F
N
L
Q
D
G
-
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
------------
D
------------
E
--------------------------------------------------
N
G
D
L
G
P
V
Y
G
K
Q
W
R
A
W
P
--
T
------------------------
P
--------
D
G
--------
R
H
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
-
I
K
R
K
P
E
S
I
F
D
Y
--------
R
F
---
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
9
PsiBlast_PDB
48.70
66%
-26
- C8 -
1TLC
3
TYSY_ECOLI
A:
[4-265]
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
-
H
Q
M
R
F
N
L
Q
D
G
-
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
------------
D
------------
E
--------------------------------------------------
N
G
D
L
G
P
V
Y
G
K
Q
W
R
A
W
P
--
T
------------------------
P
--------
D
G
--------
R
H
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
-
I
K
R
K
P
E
S
I
F
D
Y
--------
R
F
---
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
10
PsiBlast_PDB
48.54
66%
-28
- C8 -
1TSD
5
TYSY_ECOLI
A:
[4-265]
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
-
H
Q
M
R
F
N
L
Q
D
G
-
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
------------
D
------------
E
--------------------------------------------------
N
G
D
L
G
P
V
Y
G
K
Q
W
R
A
W
P
--
T
------------------------
P
--------
D
G
--------
R
H
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
-
I
K
R
K
P
E
S
I
F
D
Y
--------
R
F
---
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
19
PsiBlast_PDB
48.08
66%
-26
- C8 -
1SYN
3
TYSY_ECOLI
A:
[4-265]
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
-
H
Q
M
R
F
N
L
Q
D
G
-
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
------------
D
------------
E
--------------------------------------------------
N
G
D
L
G
P
V
Y
G
K
Q
W
R
A
W
P
--
T
------------------------
P
--------
D
G
--------
R
H
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
-
I
K
R
K
P
E
S
I
F
D
Y
--------
R
F
---
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
12
PsiBlast_PDB
47.82
66%
-29
- C8 -
1TDU
3
TYSY_ECOLI
A:
[4-265]
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
-
H
Q
M
R
F
N
L
Q
D
G
-
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
------------
D
------------
E
--------------------------------------------------
N
G
D
L
G
P
V
Y
G
K
Q
W
R
A
W
P
--
T
------------------------
P
--------
D
G
--------
R
H
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
-
I
K
R
K
P
E
S
I
F
D
Y
--------
R
F
---
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
16
PsiBlast_PDB
47.79
66%
-25
- C8 -
1BID
1
TYSY_ECOLI
A:
[4-265]
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
-
H
Q
M
R
F
N
L
Q
D
G
-
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
------------
D
------------
E
--------------------------------------------------
N
G
D
L
G
P
V
Y
G
K
Q
W
R
A
W
P
--
T
------------------------
P
--------
D
G
--------
R
H
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
-
I
K
R
K
P
E
S
I
F
D
Y
--------
R
F
---
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
15
PsiBlast_PDB
47.78
66%
-23
- C8 -
1BDU
1
TYSY_ECOLI
A:
[4-265]
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
-
H
Q
M
R
F
N
L
Q
D
G
-
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
------------
D
------------
E
--------------------------------------------------
N
G
D
L
G
P
V
Y
G
K
Q
W
R
A
W
P
--
T
------------------------
P
--------
D
G
--------
R
H
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
-
I
K
R
K
P
E
S
I
F
D
Y
--------
R
F
---
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
14
PsiBlast_PDB
47.63
66%
-27
- C8 -
1AXW
3
TYSY_ECOLI
A:
[4-265]
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
-
H
Q
M
R
F
N
L
Q
D
G
-
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
------------
D
------------
E
--------------------------------------------------
N
G
D
L
G
P
V
Y
G
K
Q
W
R
A
W
P
--
T
------------------------
P
--------
D
G
--------
R
H
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
-
I
K
R
K
P
E
S
I
F
D
Y
--------
R
F
---
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
11
PsiBlast_PDB
47.55
66%
-24
- C8 -
1DDU
3
TYSY_ECOLI
A:
[4-265]
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
-
H
Q
M
R
F
N
L
Q
D
G
-
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
------------
D
------------
E
--------------------------------------------------
N
G
D
L
G
P
V
Y
G
K
Q
W
R
A
W
P
--
T
------------------------
P
--------
D
G
--------
R
H
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
-
I
K
R
K
P
E
S
I
F
D
Y
--------
R
F
---
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I
13
PsiBlast_PDB
47.26
66%
-24
- C8 -
1AN5
1
TYSY_ECOLI
A:
[4-265]
M
K
Q
Y
L
E
L
M
Q
K
V
L
D
E
G
T
Q
K
N
D
R
T
G
T
G
T
L
S
I
F
G
-
H
Q
M
R
F
N
L
Q
D
G
-
F
P
L
V
T
T
K
R
C
H
L
R
S
I
I
H
E
L
L
W
F
L
Q
G
D
T
N
I
A
Y
L
H
E
N
N
V
T
I
W
D
E
W
A
------------
D
------------
E
--------------------------------------------------
N
G
D
L
G
P
V
Y
G
K
Q
W
R
A
W
P
--
T
------------------------
P
--------
D
G
--------
R
H
I
D
Q
I
T
T
V
L
N
Q
L
K
N
D
P
D
S
R
R
I
I
V
S
A
W
N
V
G
E
L
D
K
M
A
L
A
P
C
H
A
F
F
Q
F
--
Y
V
---
A
D
---
G
K
L
S
C
Q
L
Y
Q
R
S
C
D
V
F
L
G
L
P
F
N
I
A
S
Y
A
L
L
V
H
M
M
A
Q
Q
C
D
L
E
V
G
D
F
V
W
T
G
G
D
T
H
L
Y
S
N
H
M
D
Q
T
H
L
Q
L
S
R
E
P
R
P
L
P
K
L
I
-
I
K
R
K
P
E
S
I
F
D
Y
--------
R
F
---
E
D
F
E
I
E
G
Y
D
P
H
P
G
I
K
A
P
V
A
I