@TOME V2.3
(Nov 2016)

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Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : 5HT2B_HUMAN: (2016-01-08 )
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV

Atome Classification :

(21 SA) .........10........20........30........40........50........60........70--.........80........90........100.......110.......120.......130.......140.......150.......160....---...170.......180.......190.......--200----.-----.......210...-...------.220.......230.....-..240.......250.-------------------......260-----.------.-----------------.------.--------------.--------.-----.-----270------.--------------.------------------------.------.----.--------------.---------------------.-----..-280-------------.--------.------------------------..---------.---..--------------------------.------------290-------.----------------------------.--------..-----.----.-..--------.-----------------300----...--------..-------....310......----------.320.......330.......340.......350......-.360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIG---GNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQY---NSRATAFIKITVVWLISIGIAIPVPIKGIETDV--DN-----P-----NNITCVLTKERFG-DFM------LFGSLAAFFTPLAIMIVTY-FLTIHALQKKAYLVKN-------------------KPPQRLTWL-----T------V-----------------S------T--------------V--------F-----Q-----R--------D--------------E------------------------T------P----C--------------S---------------------S-----PE-KV--------------A--------M------------------------LD---------G---SR--------------------------K------------D---------K----------------------------A--------LP-----N----S-GD--------E-----------------T------LMR--------RT-------STIGKKSVQTISN----------EQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTL-QMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
1 PsiBlast_PDB 98.7377%-157 - C4 -4IB4 5HT2B_HUMAN (first) A:[23-416] -----------------------------------------------EEQGNKLHWAALLILMVIIPTIG---GNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIKKPIQANQY---NSRATAFIKITVVWLISIGIAIPVPIKGIET-----N-----P-----NNITCVLTKERFG-DFM------LFGSLAAFFTPLAIMIVTY-FLTIHALQKKAADLEDNWETLNDNLKVIEKADNAAQVKDALTKM-----R------A-----------------A------A--------------L--------D-----A-----Q--------K---------------------------------------------------------------------------------------------------------------------------------------------------KDFRHGFDILVG---QI--------------------------D------------D---------AL---------------------------K--------LA-----N----E-GKVKEAQAAAE-----------------Q------LKT--------TR-------NAYIQKYLQTISN----------EQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTL-QMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYR---------------------------------------------------------------------------------
2 PsiBlast_PDB 97.7777%-159 - C4 -4NC3 C562_ECOLX A:[23-416] -----------------------------------------------EEQGNKLHWAALLILMVIIPTIG---GNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIWHLCAISVDRYIAIKKPIQANQY---NSRATAFIKITVVWLISIGIAIPVPIKGIET-V--DN-----P-----NNITCVLTKERFG-DFM------LFGSLAAFFTPLAIMIVTY-FLTIHALQKKAADLEDNWETLNDNLKVIEKADNAAQVKDALTKM-----R------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDFRHGFDILVG---QI--------------------------D------------D---------AL---------------------------K--------LA-----N----E-GKVKEAQAAAE-----------------Q------LKT--------TR-------NAYIQKYLQTISN----------EQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTL-QMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYR---------------------------------------------------------------------------------
61 HHSearch 76.7329%-139 - C4 -3PBL DRD3_HUMAN (first) A:[41-472] --------------------------------------------------------YALSYCALILAIVF---GNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASIWNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLF-GFNTT----------G-----DPTVCSISNP----DFV------IYSSVVSFYLPFGVTVLVY-ARIYVVLKQRRRKNIF-------------------EMLRIDEGLRLKIYK------D-----------------T------E--------------G--------YYTIGIG-----H--------L--------------LTK----------------------S------P----SLNAAKSELDKAIGRN---------------------TNGVITKD-EA--------------EK-------LFNQDVDAAVRGILRNAKLKPVYDSLD---------A---VRRAALINMVFQMGETGVAGFTNSLRMLQ------------Q---------K----------------------------RWDEAAVNLAK-----S----R-WY--------N-----------------Q------TPNRAKRVIT-TF-------RTGTWDAYGVPLR----------EKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCH--VS-PELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC------------------------------------------------------------------------------------
57 HHSearch 76.3728%-127 - C4 -2RH1 ADRB2_HUMAN (first) A:[40-477] -----------------------------------------------------VVGMGIVMSLIVLAIVF---GNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMK-MWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSL---LTKNKARVIILMVWIVSGLTSFLPIQMHWYRAT--HQ-----EAINCYAEETCCDFFT-NQ-AYA------IASSIVSFYVPLVIMVFVY-SRVFQEAKRQLNIFEM-------------------LRIDEGLRL-----KIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKA-------------I--------G-----R-----N--------T--------------N------------------------G------V----ITKDE----------AEKLFNQDVDAAVRGILRNAKLK-----PV-YDSLDAVRRAALINMVF--------Q------------------------MG---------ETGVAG--------------------------F------------TNSLRMLQQKRWDEA------------------------AVNL-----AK-----SR---W-YN--------Q-----------------TPNRAKRVIT--------TF-------RTGTWDAYKFCLK----------EHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNL---IR-KEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLCL------------------------------------------------------------------------------------
53 HHSearch 75.2325%-120 - C4 -3UON ACM2_HUMAN (first) A:[24-457] ------------------------------------------------------VFIVLVAGSLSLVTII---GNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIG-YWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVK---RTTKMAGMMIAAAWVLSFILWAPAILF-WQFIVGVRT-----V-----EDGECYIQFFSNA-AVT------FGTAIAAFYLPVIIMTVLY-WHISRASKSRINIFEM-------------------LRIDEGLRL-----K------I-----------------Y------K--------------DTEGYYTIGI-----GHLLTKSPSLNAAKSELDKAIGRNTNGVITK------------------------D------E----A--------------E---------------------K-----LF-NQDV------------DA-------A------------------------VR---------G---ILRNAKLKPVYDSLDAV-----------RRAALINMVFQMGE---------T----------------------------G--------VAGFTNSLRMLQQ-KRWD------EAAVNLAKSRWYN-----Q------TPNRAKRVIT-TF-------RTGTWDAYPPPSR----------EKKVTRTILAILLAFIITWAPYNVMVLINTFCAPC---IP-NTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLM-------------------------------------------------------------------------------------
56 HHSearch 75.1425%-124 - C4 -3RZE ENLYS_BPT4 (first) A:[10-443] -------------------------------------------------------PLVVVLSTICLVTVG---LNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMS-KWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKY---RTKTRASATILGAWFLSFLWVIPILGWNH-------------R-----REDKCETDFYDVT-WFK------VMTAIINFYLPTLLMLWFY-AKIYKAVRQHCNIFEM-------------------LRIDEGLRLKIY--KDTE---G-----------------Y------YTIG-----------I--------G-----H-----LL-------T--------------KSPSLNAAKSELDKAIGRNTNGVITK------D----E--------------A---------------------E-----KL-FN--------------Q--------D------------------------VD---------A---AV--------------------------R------------GILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTN--------SL-----R----M-LQ--------QKRWDEAAVNLAKSRWYNQ------TPN--------RAKRVITTFRTGTWDAYLHMNR----------ERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCC---N-EHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHI------------------------------------------------------------------------------------
4 PsiBlast_PDB 75.0027%-115 - C4 -4IAR C562_ECOLX A:[9-395] ---------------------------------------------YIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTV-TGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAK---RTPKRAAVMIALVWVFSISISLP-PFFWRQA------------------S-ECVVNTDHIL--YT------VYSTVGAFYFPTLLLIALYGRIYVEARSRIADLEDNWETLNDNLKVIEKADNAA-QVKDALTKM-----R------A-----------------A------A--------------L--------D-----A-----Q--------K--------------A------------------------T------PPKLED--------------K---------------------S-----PD-SP--------------E--------M------------------------KD---------F---RH--------------------------G------------F---------D----------------------------I--------LV-----G----Q-ID--------D-----------------A------LKLANEGKV--KE-------AQAAAEQLKTTRNAYIQKYLAARERKATKTLGIILGAFIVCWLPFFIISLVMPI-----WFHL-A-IFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK-----------------------------------------------------------------------------------
17 PsiBlast_PDB 73.4430%-154 - C4 -3ZPR ADRB1_MELGA A:[15-299] ---------------------------------------------------------SLLMALVVLLIVA---GNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGA-TLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL---MTRARAKVIICTVWAISALVSF-LPIMMHWWRD--ED-----P-----QALKC-YQDPGCC-DFVTNRAYAIASSIISFYIPLLIMI----FVALRVYRE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-----KE-Q---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLMR----------EHKALKTLGIIMGVFTLCWLPFFLVNIVNVF----NRDLVPDWLFVAFNWLGYANSAMNPIIYCR-SPDFRKAFKRLL--------------------------------------------------------------------------------------
11 PsiBlast_PDB 73.3530%-152 - C4 -2Y01 ADRB1_MELGA A:[15-300] ---------------------------------------------------------SLLMALVVLLIVA---GNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGA-TLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL---MTRARAKVIICTVWAISALVSF-LPIMMHWWRD--ED-----P-----QALKC-YQDPGCC-DFVTNRAYAIASSIISFYIPLLIMI----FVALRVYRE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-----KE-Q------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRV------MLMR----------EHKALKTLGIIMGVFTLCWLPFFLVNIVNVF----NRDLVPDWLFVAFNWLGYANSAMNPIIYCR-SPDFRKAFKRLLA-------------------------------------------------------------------------------------
10 PsiBlast_PDB 73.2630%-155 - C4 -2Y00 ADRB1_MELGA A:[15-300] ---------------------------------------------------------SLLMALVVLLIVA---GNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGA-TLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL---MTRARAKVIICTVWAISALVSF-LPIMMHWWRD--ED-----P-----QALKC-YQDPGCC-DFVTNRAYAIASSIISFYIPLLIMI----FVALRVYRE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-----KE-Q------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SRV------MLMR----------EHKALKTLGIIMGVFTLCWLPFFLVNIVNVF----NRDLVPDWLFVAFNWLGYANSAMNPIIYCR-SPDFRKAFKRLLA-------------------------------------------------------------------------------------
13 PsiBlast_PDB 73.1030%-156 - C4 -2Y03 ADRB1_MELGA A:[15-300] ---------------------------------------------------------SLLMALVVLLIVA---GNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGA-TLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL---MTRARAKVIICTV