@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : 5HT2B_HUMAN: (2016-01-08 )
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70--.........80........90........100.......110.......120.......130.......140.......150.......160....---...170.......180.......190.......--200----.-----.......210...-...------.220.......230.....-..240.......250.-------------------......260-----.------.-----------------.------.--------------.--------.-----.-----270------.--------------.------------------------.------.----.--------------.---------------------.-----..-280-------------.--------.------------------------..---------.---..--------------------------.------------290-------.----------------------------.--------..-----.----.-..--------.-----------------300----...--------..-------....310......----------.320.......330.......340.......350......-.360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAL
S
Y
R
V
S
E
L
Q
S
T
I
P
E
H
I
L
Q
S
T
F
V
H
V
ISSNWSGLQ
T
E
S
I
P
E
E
M
K
Q
I
V
E
EQGNK
L
H
W
A
A
L
L
I
L
M
V
I
I
PTIG---G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
M
P
I
A
L
L
T
I
M
F
E
AMWP
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
M
H
L
CAISV
D
R
Y
I
A
IKKPIQANQY---NSR
A
T
A
F
I
K
I
T
V
V
W
L
I
SIGIAIPVPIKGIETDV--DN-----P-----N
N
I
T
C
V
L
T
K
E
RFG-
D
F
M
------
L
F
G
S
L
A
A
F
F
T
P
L
A
I
M
I
V
T
Y
-
F
L
T
I
H
A
L
Q
K
K
A
Y
L
VKN-------------------KPPQ
R
L
T
W
L
-----
T
------
V
-----------------
S
------
T
--------------
V
--------
F
-----Q-----R--------D--------------E------------------------T------P----C--------------S---------------------S-----P
E
-
K
V
--------------
A
--------M------------------------LD---------G---SR--------------------------K------------D---------K----------------------------A--------LP-----N----S-
G
D
--------
E
-----------------
T
------
L
M
R
--------
R
T
-------
S
TIG
K
K
S
V
Q
T
I
S
N
----------
E
Q
R
A
S
K
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
F
F
I
T
N
I
T
L
V
L
CDSC
N
Q
T
T
L
-
Q
M
L
L
E
I
F
V
W
I
G
Y
V
S
SG
V
N
P
L
V
Y
T
L
F
N
K
T
F
R
D
AFG
R
Y
I
T
C
N
YRA
T
K
S
V
K
T
L
R
K
RSS
K
I
Y
F
RNPMAE
N
S
K
F
F
K
K
HGIRNGI
N
P
A
M
Y
Q
S
P
M
R
L
R
S
STIQSS
S
I
I
L
L
D
T
L
L
L
TENEGDK
T
E
E
QVSYV
1
PsiBlast_PDB
98.73
77%
-157
- C4 -
4IB4
11
5HT2B_HUMAN (first)
A:
[23-416]
-----------------------------------------------
E
E
Q
G
N
K
L
H
W
A
A
L
L
I
L
M
V
I
I
P
T
I
G
---
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
M
P
I
A
L
L
T
I
M
F
E
A
M
W
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
Q
A
N
Q
Y
---
N
S
R
A
T
A
F
I
K
I
T
V
V
W
L
I
S
I
G
I
A
I
P
V
P
I
K
G
I
E
T
-----
N
-----
P
-----
N
N
I
T
C
V
L
T
K
E
R
F
G
-
D
F
M
------
L
F
G
S
L
A
A
F
F
T
P
L
A
I
M
I
V
T
Y
-
F
L
T
I
H
A
L
Q
K
K
A
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
ADN
A
A
Q
V
K
D
A
L
T
K
M
-----
R
------
A
-----------------
A
------
A
--------------
L
--------
D
-----
A
-----
Q
--------
K
---------------------------------------------------------------------------------------------------------------------------------------------------
K
D
F
R
H
G
F
D
I
L
V
G
---
Q
I
--------------------------
D
------------
D
---------
A
L
---------------------------
K
--------
L
A
-----
N
----
E
-
G
K
V
K
E
A
Q
A
A
A
E
-----------------
Q
------
L
K
T
--------
T
R
-------
N
A
Y
I
Q
K
Y
L
Q
T
I
S
N
----------
E
Q
R
A
S
K
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
F
F
I
T
N
I
T
L
V
L
C
D
S
C
N
Q
T
T
L
-
Q
M
L
L
E
I
F
V
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
T
F
R
D
A
F
G
R
Y
I
T
C
N
Y
R
---------------------------------------------------------------------------------
2
PsiBlast_PDB
97.77
77%
-159
- C4 -
4NC3
13
C562_ECOLX
A:
[23-416]
-----------------------------------------------
E
E
Q
G
N
K
L
H
W
A
A
L
L
I
L
M
V
I
I
P
T
I
G
---
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
M
P
I
A
L
L
T
I
M
F
E
A
M
W
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
P
I
Q
A
N
Q
Y
---
N
S
R
A
T
A
F
I
K
I
T
V
V
W
L
I
S
I
G
I
A
I
P
V
P
I
K
G
I
E
T
-
V
--
D
N
-----
P
-----
N
N
I
T
C
V
L
T
K
E
R
F
G
-
D
F
M
------
L
F
G
S
L
A
A
F
F
T
P
L
A
I
M
I
V
T
Y
-
F
L
T
I
H
A
L
Q
K
K
A
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
ADN
A
A
Q
V
K
D
A
L
T
K
M
-----
R
------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
F
R
H
G
F
D
I
L
V
G
---
Q
I
--------------------------
D
------------
D
---------
A
L
---------------------------
K
--------
L
A
-----
N
----
E
-
G
K
V
K
E
A
Q
A
A
A
E
-----------------
Q
------
L
K
T
--------
T
R
-------
N
A
Y
I
Q
K
Y
L
Q
T
I
S
N
----------
E
Q
R
A
S
K
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
F
F
I
T
N
I
T
L
V
L
C
D
S
C
N
Q
T
T
L
-
Q
M
L
L
E
I
F
V
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
T
F
R
D
A
F
G
R
Y
I
T
C
N
Y
R
---------------------------------------------------------------------------------
61
HHSearch
76.73
29%
-139
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
---
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
-
G
F
N
T
T
----------
G
-----
D
P
T
V
C
S
I
S
N
P
----
D
F
V
------
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
-
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
-------------------
E
M
L
R
I
D
E
G
L
RL
K
I
Y
K
------
D
-----------------
T
------
E
--------------
G
--------
Y
Y
T
I
G
I
G
-----
H
--------
L
--------------
L
TK----------------------
S
------
P
----
S
L
N
A
A
K
S
E
L
D
K
A
I
GR
N
---------------------
T
NGVIT
K
D
-
E
A
--------------
E
K
-------
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
---------
A
---
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
------------
Q
---------
K
----------------------------
R
W
D
E
A
A
V
N
L
A
K
-----
S
----
R
-
W
Y
--------
N
-----------------
Q
------
T
P
N
R
A
K
R
V
I
T
-
T
F
-------
R
T
G
T
W
D
A
Y
G
V
P
L
R
----------
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
H
--
V
S
-
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
------------------------------------------------------------------------------------
57
HHSearch
76.37
28%
-127
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-----------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
---
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
--
H
Q
-----
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
-
N
Q
-
A
Y
A
------
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
-------------------
L
R
I
D
E
G
L
R
L
-----
K
I
Y
K
D
TE
G
YYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
-------------
I
--------
G
-----
R
-----
N
--------
T
--------------
N
------------------------
G
------
V
----
I
T
K
D
E
----------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
-----
P
V
-
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
--------
Q
------------------------
M
G
---------
E
T
G
V
A
G
--------------------------
F
------------
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
------------------------
A
V
N
L
-----
A
K
-----
S
R
---
W
-
Y
N
--------
Q
-----------------
T
P
N
R
A
K
R
V
I
T
--------
T
F
-------
R
T
G
T
W
D
A
Y
K
F
C
L
K
----------
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
---
I
R
-
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------------------------------------------------------------
53
HHSearch
75.23
25%
-120
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
---
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
I
G
-
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-
W
Q
F
I
V
GV
R
T
-----
V
-----
E
D
G
E
C
Y
I
Q
F
F
S
N
A
-
A
V
T
------
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
-
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
-------------------
L
R
I
D
E
G
L
R
L
-----
K
------
I
-----------------
Y
------
K
--------------
D
TEG
Y
Y
T
I
G
I
-----
G
HLLTK
S
PS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
------------------------
D
------
E
----
A
--------------
E
---------------------
K
-----
L
F
-
N
Q
D
V
------------
D
A
-------
A
------------------------
V
R
---------
G
---
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
-----------
R
R
A
A
L
I
N
M
V
F
Q
MG
E
---------
T
----------------------------
G
--------
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-
K
R
W
D
------
E
A
A
V
N
L
A
K
S
R
W
Y
N
-----
Q
------
T
P
N
R
A
K
R
V
I
T
-
T
F
-------
R
T
G
T
W
D
A
Y
P
P
P
S
R
----------
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
---
I
P
-
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-------------------------------------------------------------------------------------
56
HHSearch
75.14
25%
-124
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
---
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
M
S
-
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
N
H
-------------
R
-----
R
E
D
K
C
E
T
D
F
Y
D
V
T
-
W
F
K
------
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
-
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
-------------------
L
R
I
D
E
G
L
R
L
K
I
Y
--
K
D
TE---
G
-----------------
Y
------
Y
T
I
G
-----------
I
--------
G
-----
H
-----
L
L-------
T
--------------
K
SPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
------
D
----
E
--------------
A
---------------------
E
-----
K
L
-
F
N
--------------
Q
--------
D
------------------------
V
D
---------
A
---
A
V
--------------------------
R
------------
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
--------
S
L
-----
R
----
M
-
L
Q
--------
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
------
T
P
N
--------
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
L
H
M
N
R
----------
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
C
C
---
N
-
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.00
27%
-115
- C4 -
4IAR
2
C562_ECOLX
A:
[9-395]
---------------------------------------------
Y
I
Y
Q
D
S
I
S
L
P
W
K
V
L
L
V
M
L
L
A
L
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
M
P
I
S
T
M
Y
T
V
-
T
G
R
W
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
A
V
E
Y
S
A
K
---
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
S
I
S
I
S
L
P
-
P
F
F
W
R
Q
A
------------------
S
-
E
C
V
V
N
T
D
H
I
L
--
Y
T
------
V
Y
S
T
V
G
A
F
Y
F
P
T
L
L
L
I
A
L
Y
G
R
I
Y
V
E
A
R
S
R
I
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
ADN
A
A
-
Q
V
K
D
A
L
T
K
M
-----
R
------
A
-----------------
A
------
A
--------------
L
--------
D
-----
A
-----
Q
--------
K
--------------
A
------------------------
T
------
P
PKL
E
D
--------------
K
---------------------
S
-----
P
D
-
S
P
--------------
E
--------
M
------------------------
K
D
---------
F
---
R
H
--------------------------
G
------------
F
---------
D
----------------------------
I
--------
L
V
-----
G
----
Q
-
I
D
--------
D
-----------------
A
------
L
K
L
A
N
E
GK
V
--
K
E
-------
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
A
A
R
E
R
K
A
T
K
T
L
G
I
I
L
G
A
F
I
V
C
W
L
P
F
F
I
I
S
L
V
M
P
I
-----
W
F
H
L
-
A
-
I
F
D
F
F
T
W
L
G
Y
L
N
S
L
I
N
P
I
I
Y
T
M
S
N
E
D
F
K
Q
A
F
H
K
L
I
R
F
K
-----------------------------------------------------------------------------------
17
PsiBlast_PDB
73.44
30%
-154
- C4 -
3ZPR
11
ADRB1_MELGA
A:
[15-299]
---------------------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
--
E
D
-----
P
-----
Q
A
L
K
C
-
Y
Q
D
P
G
C
C
-
D
F
V
TN
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
----
F
V
A
L
R
V
Y
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
K
E
-
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
M
R
----------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
--------------------------------------------------------------------------------------
11
PsiBlast_PDB
73.35
30%
-152
- C4 -
2Y01
12
ADRB1_MELGA
A:
[15-300]
---------------------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
--
E
D
-----
P
-----
Q
A
L
K
C
-
Y
Q
D
P
G
C
C
-
D
F
V
TN
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
----
F
V
A
L
R
V
Y
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
K
E
-
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
------
M
L
M
R
----------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------------
10
PsiBlast_PDB
73.26
30%
-155
- C4 -
2Y00
13
ADRB1_MELGA
A:
[15-300]
---------------------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
--
E
D
-----
P
-----
Q
A
L
K
C
-
Y
Q
D
P
G
C
C
-
D
F
V
TN
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
----
F
V
A
L
R
V
Y
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
K
E
-
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
------
M
L
M
R
----------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------------
13
PsiBlast_PDB
73.10
30%
-156
- C4 -
2Y03
9
ADRB1_MELGA
A:
[15-300]
---------------------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
--
E
D
-----
P
-----
Q
A
L
K
C
-
Y
Q
D
P
G
C
C
-
D
F
V
TN
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
----
F
V
A
L
R
V
Y
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
K
E
-
Q
I
--------------
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
------
M
L
M
R
----------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------------
16
PsiBlast_PDB
73.08
30%
-153
- C4 -
3ZPQ
11
ADRB1_MELGA
A:
[15-300]
---------------------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
--
E
D
-----
P
-----
Q
A
L
K
C
-
Y
Q
D
P
G
C
C
-
D
F
V
TN
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
----
F
V
A
L
R
V
Y
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
K
E
-
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
------
M
L
M
R
----------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------------
9
PsiBlast_PDB
72.87
28%
-139
- C4 -
4GBR
1
ADRB2_HUMAN
A:
[9-286]
---------------------------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
---
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
T
K
T
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
-
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
--
T
H
-----
Q
-----
E
A
I
N
C
-
Y
A
E
E
T
C
C
-
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
---------------------------------------------------------------------------
S
------
R
--------------
V
--------
F
-----
Q
-----
E
--------
A
--------------
K
------------------------
R
------
Q
----
L
--------------
Q
---------------------
K
-----
I
D
-
K
F
--------------
C
--------
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
E
V
-
Y
I
L
L
N
---
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
-----------
Q
E
L
L
C
L
-------------------------------------------------------------------------
59
HHSearch
72.84
23%
-124
- C4 -
3EML
13
ENLYS_BPT4
A:
[21-472]
-----------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
G
--
Q
-SQGCG
E
-----
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
------
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
-
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
-------------------
L
R
I
D
E
G
L
R
L
-----
K
------
I
-----------------
Y
------
K
D
TEGYYTIGIGHLL
T
--------
K
SPS
L
N
A
-----
A
K
-------
S
E
-------------
L
------------------------
D
K
A
I
GRN
T
----
N
--------------
G
VI-------------------
T
-----
K
D
E
A
E
K
L
F
N
Q
D
V
-------
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
---
V
F
---------
Q
---
M
G
--------------------------
E
T
G
V
A
G
F
T
N
S
---
L
---------
R
----------------------------
M
--------
L
Q
-----
Q
----
K
R
W
D
--------
E
A
A
V
N
L
A
K
----------
S
R
W
Y
N
Q
-
T
P
N
R
A
K
R
V
I
T
T
F
R
-------
T
G
T
W
D
A
Y
R
S
T
L
Q
K
----------
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
-
H
A
P
-
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-------------------------------------------------------------------------------
15
PsiBlast_PDB
72.78
30%
-154
- C4 -
4AMJ
12
ADRB1_MELGA
A:
[15-300]
---------------------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
--
E
D
-----
P
-----
Q
A
L
K
C
-
Y
Q
D
P
G
C
C
-
D
F
V
TN
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
----
F
V
A
L
R
V
Y
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
K
E
-
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
------
M
L
M
R
----------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.49
30%
-155
- C4 -
2Y04
13
ADRB1_MELGA
A:
[15-300]
---------------------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
--
E
D
-----
P
-----
Q
A
L
K
C
-
Y
Q
D
P
G
C
C
-
D
F
V
TN
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
----
F
V
A
L
R
V
Y
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
K
E
-
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
------
M
L
M
R
----------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------------
12
PsiBlast_PDB
72.24
30%
-153
- C4 -
2Y02
13
ADRB1_MELGA
A:
[15-300]
---------------------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
--
E
D
-----
P
-----
Q
A
L
K
C
-
Y
Q
D
P
G
C
C
-
D
F
V
TN
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
----
F
V
A
L
R
V
Y
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
K
E
-
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
------
M
L
M
R
----------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------------
18
PsiBlast_PDB
71.97
30%
-153
- C4 -
2VT4
8
ADRB1_MELGA
A:
[15-298]
---------------------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
--
E
D
-----
P
-----
Q
A
L
K
C
-
Y
Q
D
P
G
C
C
-
D
F
V
TN
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
----
F
V
A
L
R
V
Y
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
K
E
-
Q
I
--------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------------
20
PsiBlast_PDB
71.48
30%
-144
- C4 -
2YCX
3
ADRB1_MELGA
A:
[15-294]
---------------------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
--
E
D
-----
P
-----
Q
A
L
K
C
-
Y
Q
D
P
G
C
C
-
D
F
V
TN
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
----
F
V
A
L
R
V
Y
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
K
E
-
Q
I
--------------
R
--------
K
------------------------
I
D
---------
R
---
A
S
--------------------------
K
------------
R
---------
K
----------------------------
R
--------
V
-----------------------------------------
M
------
L
M
R
----------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
-----------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.48
30%
-139
- C4 -
3SN6
1
R:
[186-490]
---------------------------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
---
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
T
K
T
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
-
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
----------
Q
-----
E
A
I
N
C
-
Y
A
E
E
T
C
C
-
D
F
F
TNQAYA
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
---------------------------------------------------------------------------
S
------
R
--------------
V
--------
F
-----
Q
---------------------------------------------------------------------------------
E
---------------------
A
-----
K
R
-
Q
L
--------------
Q
--------
K
------------------------
I
D
---------
K
---
S
E
--------------------------
G
------------
R
------------------------------------------------------------------------------------------------------------------------------
C
L
K
----------
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
E
V
-
Y
I
L
L
N
---
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
-----------
Q
E
L
L
C
--------------------------------------------------------------------------
19
PsiBlast_PDB
71.06
30%
-149
- C4 -
2YCW
7
ADRB1_MELGA
A:
[15-299]
---------------------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
---
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
--
E
D
-----
P
-----
Q
A
L
K
C
-
Y
Q
D
P
G
C
C
-
D
F
V
TN
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
----
F
V
A
L
R
V
Y
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
K
E
-
Q
I
--------------
R
--------
K
------------------------
I
D
---------
R
---
A
S
--------------------------
K
------------
R
---------
K
----------------------------
R
--------
V
-----------------------------------------
M
------
L
M
R
----------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
----
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
------------------------------------------------------------------------------------