@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GIPR_HUMAN: (2016-01-09 )
MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
Atome Classification :
(21 SA)
---------.........10........20........30........40........50..-...-...60........70.--.......80........90...-.....100.......------110------...----------..-...120.....--..130--------.......140.......150.......----160.......170.......180.....-..190..-.....200........--210.......220---.......230.......240.......-----250---.---.---......260.......270......-.-280-.----......--.-.290------.-----.------.----.-.----.----..300.......310.......320....----------.-.-------------------------------------------------------------------------------------------------------------------------------------------------------.330.......340........350-.......----360..---..------------.----..370.....---..380.......-------390....---------------...400.......410..-....-.420.......430.-----......440.......450.......460....-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------M
T
T
S
P
I
L
Q
L
L
L
R
L
S
L
C
G
L
L
L
Q
RAETGSKGQ
T
A
G
E
L
Y
Q
R
W
E
R
Y
R
R
E
C
Q
E
T
L
AAA-EPP-S
G
L
ACNGSF
D
M
Y
V
C
W
D--YAAPNATARASCPWYL
P
W
H
H
H
V
-
A
A
G
F
V
L
R
QCGSDGQW------GL-------WRD----------HT-QCENPE
K
N
E
A
F
--
L
D
Q
R
L
--------
I
L
E
R
L
Q
V
M
Y
TVGY
S
L
S
L
A
T
L
L
L
A
L
L
I
L
----
S
L
F
R
R
L
H
CTR
N
Y
I
H
I
N
L
F
T
S
F
M
L
R
A
A
A
I
-
L
S
RDRLL-PRPGPYL-G
D
Q
A
L
A
L
W
--
N
Q
A
L
A
A
C
R
T
A
Q
I
V
---
T
Q
Y
C
VGA
N
Y
T
W
L
L
V
E
G
V
Y
L
H
S
L
L
V
L
VG-----GS----E---E---
G
H
F
R
Y
Y
L
L
L
GWGA
P
A
L
F
V
I
P
W
V
I
V
R
-
Y
-
L
---
Y
----ENTQCW--E-RNE-------
V
-----
K
------
A
----
I
-
W
----
W
----
I
IR
T
P
I
L
M
T
I
L
I
N
F
L
I
F
I
R
I
L
G
I
L
L
S
K
L
R
----------
T
-
R
-------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
R
C
R
D
Y
R
L
R
L
A-RS
T
L
T
L
V
PLLGV-H
E
V
V
FAP----V
T
E
E
Q
---AR------------
G
----
A
L
R
F
A
K
L
G
F
E
---
I
F
L
S
S
F
Q
G
F
L
V
S
-------
V
L
Y
C
F
I
N
---------------
K
E
V
Q
S
E
I
R
R
G
W
H
H
C
R
L
R
R
-
S
L
G
E
-
E
Q
R
Q
L
P
E
R
A
F
R
ALPS-----GSGPGEVPTSRGLSSGTLPGPG
N
E
A
S
R
E
L
E
SYC-------
1
PsiBlast_PDB
87.71
59%
-144
- C3 -
4L6R
1
C562_ECOLX (first)
A:
[125-394]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
V
M
Y
T
V
G
Y
S
L
S
L
G
A
L
L
L
A
L
A
I
L
----
G
G
L
S
K
L
H
C
T
R
N
A
I
H
A
N
L
F
A
S
F
V
L
K
A
S
S
V
-
L
V
I
D
G
L
L
R
T
---------------LS
D
G
A
V
A
G
C
R
V
A
A
V
F
---
M
Q
Y
G
I
V
A
N
Y
C
W
L
L
V
E
G
L
Y
L
H
N
L
L
G
L
A
T
-----
L
P
----
E
---
R
---
S
F
F
S
L
Y
L
G
I
G
W
G
A
P
M
L
F
V
V
P
W
A
V
V
K
-
C
-
L
---
F
----
E
N
V
Q
C
W
--
T
-
S
N
D
-------
N
-----
M
------
G
----
F
-
W
----
W
----
I
L
R
F
P
V
F
L
A
I
L
I
N
F
F
I
F
V
R
I
V
Q
L
L
V
A
K
L
R
----------
A
-
R
-------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
H
H
T
D
Y
K
F
R
L
A
-
K
S
T
L
T
L
I
P
L
L
G
V
-
H
E
V
V
F
A
F
----
V
T
D
E
H
---
A
Q
------------
G
----
T
L
R
S
A
K
L
F
F
D
---
L
F
L
S
S
F
Q
G
L
L
V
A
-------
V
L
Y
C
F
L
N
---------------
K
E
V
Q
S
E
L
R
R
R
W
H
R
W
R
L
G
K
-
V
L
W
E
-
E
R
N
---------------------------------------------------------
25
HHSearch
69.99
100%
-67
- C2 -
2QKH
1
GIPR_HUMAN
A:
[26-119]
-------------------------------------
G
Q
T
A
G
E
L
Y
Q
R
W
E
R
Y
R
R
E
C
Q
E
T
L
A
A
A
-
E
P
P
-
S
G
L
A
C
N
G
S
F
D
M
Y
V
C
W
D
--
Y
A
A
P
N
A
T
A
R
A
S
C
P
W
Y
L
P
W
H
H
H
V
-
A
A
G
F
V
L
R
Q
C
G
S
D
G
Q
W
------
G
L
-------
W
R
D
----------
H
T
-
Q
C
E
N
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
69.99
100%
-67
- C2 -
2QKH
1
GIPR_HUMAN
A:
[26-119]
-------------------------------------
G
Q
T
A
G
E
L
Y
Q
R
W
E
R
Y
R
R
E
C
Q
E
T
L
A
A
A
-
E
P
P
-
S
G
L
A
C
N
G
S
F
D
M
Y
V
C
W
D
--
Y
A
A
P
N
A
T
A
R
A
S
C
P
W
Y
L
P
W
H
H
H
V
-
A
A
G
F
V
L
R
Q
C
G
S
D
G
Q
W
------
G
L
-------
W
R
D
----------
H
T
-
Q
C
E
N
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
68.38
19%
-107
- C3 -
4K5Y
7
CRFR1_HUMAN (first)
A:
[13-423]
H
Y
H
V
A
A
I
I
N
Y
L
G
H
C
I
S
L
V
A
L
L
V
A
F
V
L
F
L
R
A
R
S
I
R
C
L
R
N
I
I
H
A
N
L
I
A
A
F
I
L
R
N
A
T
W
F
V
V
Q
L
T
M
-
S
P
E
-
V
H
Q
S
N
V
G
W
C
R
L
V
T
A
A
Y
N
Y
F
H
V
T
N
F
F
W
M
F
G
E
G
C
Y
L
H
T
A
I
V
L
-
T
N
I
F
E
M
L
R
I
D
E
G
L
R
L
------
K
I
-------
Y
K
D
TEGYYTIGIG
H
L
-
L
T
K
S
P
S
L
S
V
A
K
S
E
L
D
K
A
I
GRNSNGVI
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
----
P
V
Y
D
S
L
D
A
V
R
R
S
A
L
I
N
M
V
F
Q
M
------------------------
G
E
T
G
V
A
G
F
--
T
N
S
L
R
M
L
Q
Q
K
R
W
D
---
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
A
T
F
R
TGTW
D
A
Y
----
D
---
R
---
L
R
A
W
M
F
I
C
I
G
W
G
V
P
F
P
I
I
V
A
W
A
I
G
K
-
L
-
Y
---
Y
----
D
N
E
K
C
W
--
A
G
K
R
P
-------
G
-----
V
------
Y
----
T
-
D
----
Y
----
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
R
----------
A
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
S
E
T
I
Q
A
R
K
A
V
-
K
A
T
L
V
L
L
P
L
L
G
I
-
T
Y
M
L
A
F
V
-------------
N
------------
E
----
V
S
R
V
V
F
I
Y
F
N
---
A
F
L
E
S
F
Q
G
F
F
V
S
-------
V
F
A
C
F
L
N
---------------
S
-----------------------------------------------------------------------------------
56
Fugue
64.67
21%
-81
- C1 -
3ZPJ
-
?
A:
[1-356]
---------
M
T
T
L
E
E
I
N
L
L
V
E
R
G
Y
Y
E
E
A
L
A
K
V
Y
E
I
---
E
D
P
I
E
Q
V
Q
V
L
T
K
I
V
V
T
I
Y
Q
H
D
G
P
M
-
E
W
I
-
P
S
I
M
E
D
A
M
Y
I
A
K
K
L
R
D
------------------
P
A
N
K
A
V
-
A
Y
S
I
I
A
S
T
L
A
I
------------------------------------
M
E
Y
E
E
D
A
M
D
F
--
F
N
-
R
A
--------
I
D
E
A
N
E
I
E
S
P
I
E
K
G
M
V
L
S
T
L
A
Y
H
L
A
I
A
GY
P
D
N
A
L
E
I
F
N
I
A
F
D
T
I
I
G
A
-
E
T
S
Y
T
H
K
V
D
G
I
-
L
R
I
G
D
L
L
-
E
K
A
G
D
T
L
P
S
N
E
A
M
D
F
Y
--
K
M
A
F
D
I
F
D
K
L
H
V
----------
N
Q
R
A
A
I
V
E
K
K
I
E
L
A
K
T
V
Y
D
V
G
---------------
L
---
P
Q
I
R
A
A
L
L
K
G
K
N
H
Y
A
L
A
I
I
K
K
K
----------
Y
----
S
G
V
M
-
R
--
L
-
I
G
E
-------
L
-----
E
------
V
----
A
-
L
----
W
----
M
K
R
V
--------
N
N
M
E
Y
L
D
V
V
D
K
A
F
E
C
C
E
----------
S
-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
-
T
D
V
N
V
Q
H
I
A
-
R
L
L
T
E
L
---------------------
G
N
---
L
R
------------
R
----
A
L
K
F
A
K
---
E
---
I
Q
-----------------------
N
---------------
I
H
K
R
S
E
A
L
K
A
I
A
L
E
L
V
R
R
-
K
K
F
E
-
E
V
K
K
I
I
E
S
------------------
I
P
D
---------
P
K
I
R
E
E
A
L
N
E
I
G
T
I
E
-------
2
PsiBlast_PDB
64.22
100%
-70
- C2 -
4HJ0
-
GIPR_HUMAN
A:
[29-120]
---------------------------------------
T
A
G
E
L
Y
Q
R
W
E
R
Y
R
R
E
C
Q
E
T
L
A
A
A
-
E
P
P
-
S
G
L
A
C
N
G
S
F
D
M
Y
V
C
W
D
--
Y
A
A
P
N
A
T
A
R
A
S
C
P
W
Y
L
P
W
H
H
H
V
-
A
A
G
F
V
L
R
Q
C
G
S
D
G
Q
W
------
G
L
-------
W
R
D
----------
H
T
-
Q
C
E
N
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
62.49
34%
-118
- C3 -
4K5Y
2
CRFR1_HUMAN
C:
[286-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
C
I
G
W
G
V
P
F
P
I
I
V
A
W
A
I
G
K
-
L
-
Y
---
Y
----
D
N
E
K
C
W
AG
K
-
R
P
G
-------
V
-----
Y
------
T
----
D
-
Y
---------
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
R
----------
A
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
S
E
T
I
Q
A
R
K
A
V
-
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
F
V
N
----
P
G
E
D
E
---
V
S
-------------------
R
V
V
F
I
Y
F
N
---
A
F
L
E
S
F
Q
G
F
F
V
S
-------
V
F
A
C
F
L
N
---------------------------------------------------------------------------------------------------
55
Fugue
57.68
16%
-89
* C1 *
4EWV
3
GH312_ARATH
A:
[14-581]
-----------
N
E
T
F
E
K
Q
L
K
D
L
T
S
N
V
K
S
I
Q
D
N
L
L
E
E
I
I
T
P
D
K
E
L
F
K
K
N
V
S
Y
E
D
I
K
P
Y
L
D
R
V
V
-
N
G
E
-
S
Q
-------------
K
--
M
M
P
W
N
N
K
Y
L
D
N
L
T
F
I
Y
D
L
R
M
Q
V
-
I
T
K
H
V
------
K
G
V
E
------
M
M
-------
F
L
F
----------
T
K
-
Q
E
P
A
R
V
A
T
S
S
Y
--
F
K
S
D
Y
--------
F
K
N
R
P
S
N
W
Y
-
Y
S
Y
T
S
P
D
E
V
I
L
C
P
N
N
T
E
----
S
L
Y
C
H
L
L
C
G
L
V
-
Q
R
G
S
I
F
A
S
V
M
V
R
A
I
E
V
-
L
K
N
S
W
E
E
-
L
C
S
N
I
R
S
-
G
H
--
L
S
N
W
--
V
T
D
L
G
C
Q
N
S
V
S
L
V
L
GG
P
R
P
E
L
A
D
T
I
E
E
I
C
N
Q
N
S
W
K
G
I
V
K
R
L
W
P
-----
N
T
----
K
---------
Y
I
E
T
V
V
T
G
S
M
G
Q
Y
V
P
M
L
N
Y
Y
C
N
D
-
L
-
P
---
L
----
V
S
T
T
Y
G
--
S
-
S
E
T
-------
T
-----
F
------
G
----
I
-
N
----
L
DP--
L
C
K
P
E
D
V
S
Y
T
F
M
P
N
M
S
Y
F
E
F
I
G
C
T
Y
A
G
L
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
R
V
G
D
I
V
L
V
T
G
F
Y
N
N
A
P
Q
F
K
F
V
R
R
-
E
N
V
V
L
S
I
D
S
D
K
T
N
E
E
D
---
L
F
------------
K
----
A
V
S
Q
A
K
L
V
L
E
S
S
G
L
D
L
K
D
F
T
S
Y
A
D
T
STFP
G
H
Y
V
V
Y
L
E
V
D
TKQFELD
E
E
A
L
S
T
C
C
L
V
M
E
E
S
L
D
N
V
Y
K
R
C
R
F
K
D
G
S
I
G
P
L
E
I
R
V
V
R
Q
G
T
F
D
S
L
M
D
F
F
I
S
Q
G
A
S
T
G
Q
Y
K
T
P
R
C
I
K
S
G
-------
K
A
L
Q
V
L
E
T
C
V
V
A
K
F
F
S
I
27
HHSearch
56.89
10%
-120
- C3 -
2Z73
5
OPSD_TODPA
A:
[35-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
----
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
-
C
F
L
K
----------
K
W
--
I
F
G
F
A
A
C
K
V
Y
G
F
I
---
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
-----
A
A
S
K
K
M
S
---
H
---
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
-
G
A
Y
T
L
E
G
----
V
L
C
N
C
S
--
F
-
D
Y
I
-------
S
-----
R
D
S
T
T
R
S
N
I
L
C
M
F
-
I
----
L
----
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
-
K
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
A
G
A
N
A
E
M
R
L
A
-
K
I
S
I
V
I
V
S
Q
F
L
L
-
S
W
S
P
Y
A
V
----
V
A
L
L
A
---
Q
F
GPL---------
E
----
W
V
T
P
Y
A
A
Q
L
P
---
V
M
F
A
K
A
S
A
I
H
N
P
-------
M
I
Y
S
V
S
H
---------------
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
-
Q
F
D
D
-
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
-----
G
E
--------------------------------------
8
PsiBlast_PDB
56.11
41%
-59
- C2 -
3C5T
2
GLP1R_HUMAN
A:
[11-108]
------------------------------------------
E
T
V
Q
K
W
R
E
Y
R
R
Q
C
Q
R
S
L
T
E
D
-
P
P
P
A
T
D
L
F
C
N
R
T
F
D
E
Y
A
C
W
P
--
D
G
E
P
G
S
F
V
N
V
S
C
P
W
Y
L
P
W
A
S
S
V
-
P
Q
G
H
V
Y
R
F
C
T
A
E
G
L
W
------
L
Q
KDNSSLP
W
R
D
----------
L
S
-
E
C
E
E
S
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
56.03
41%
-59
- C2 -
3IOL
1
GLP1R_HUMAN
A:
[15-109]
------------------------------------------
E
T
V
Q
K
W
R
E
Y
R
R
Q
C
Q
R
S
L
T
E
D
-
P
P
P
A
T
D
L
F
C
N
R
T
F
D
E
Y
A
C
W
P
--
D
G
E
P
G
S
F
V
N
V
S
C
P
W
Y
L
P
W
A
S
S
V
-
P
Q
G
H
V
Y
R
F
C
T
A
E
G
L
W
------
L
Q
KDNSS
L
P
W
R
D
----------
L
S
-
E
C
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
55.58
41%
-57
- C2 -
3C59
1
GLP1R_HUMAN
A:
[11-108]
------------------------------------------
E
T
V
Q
K
W
R
E
Y
R
R
Q
C
Q
R
S
L
T
E
D
-
P
P
P
A
T
D
L
F
C
N
R
T
F
D
E
Y
A
C
W
P
--
D
G
E
P
G
S
F
V
N
V
S
C
P
W
Y
L
P
W
A
S
S
V
-
P
Q
G
H
V
Y
R
F
C
T
A
E
G
L
W
------
L
Q
KDNSSLP
W
R
D
----------
L
S
-
E
C
E
E
S
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
54.64
46%
-64
- C2 -
4ERS
2
GLR_HUMAN
A:
[5-95]
-------------------------------------------
L
F
E
K
W
K
L
Y
G
D
Q
C
H
H
N
L
S
L
L
-
P
P
P
-
T
E
L
V
C
N
R
T
F
D
K
Y
S
C
W
P
--
D
T
P
A
N
T
T
A
N
I
S
C
P
W
Y
L
P
W
H
H
K
V
-
Q
H
R
F
V
F
K
R
C
G
P
D
G
Q
W
VRGPRG
Q
P
-------
W
R
D
----------
A
S
-
Q
C
Q
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
54.52
46%
-69
- C2 -
4LF3
-
GLR_HUMAN
C:
[4-94]
-------------------------------------------
L
F
E
K
W
K
L
Y
S
D
Q
C
H
H
N
L
S
L
L
-
P
P
P
-
T
E
L
V
C
N
R
T
F
D
K
Y
S
C
W
P
--
D
T
P
A
N
T
T
A
N
I
S
C
P
W
Y
L
P
W
H
H
K
V
-
Q
H
R
F
V
F
K
R
C
G
P
D
G
Q
W
VRGPRG
Q
P
-------
W
R
D
----------
A
S
-
Q
C
Q
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
52.09
12%
-116
- C3 -
2KS9
1
NK1R_HUMAN
A:
[35-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
----
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
-
A
V
H
N
----------
E
W
--
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
---
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
-----
Q
P
----
R
LS-
A
---
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
-
T
-
T
---
E
TMP-
S
R
V
V
C
M
--
I
-
E
W
P
EHP----
N
KIY
E
K
V
------
Y
H
I
C
V
T
-
V
----
L
----
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
S
----------
S
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------
Y
H
E
Q
V
S
A
K
R
K
V
V
-
K
M
M
I
V
V
V
C
T
F
A
I
-
C
W
L
P
F
H
I
----
F
F
L
L
P
---
Y
I
NPDLYL------
K
----
K
F
I
Q
Q
V
Y
L
A
I
---
M
W
L
A
M
S
S
T
M
Y
N
P
-------
I
I
Y
C
C
L
N
---------------
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
-
A
G
D
Y
-
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
-----
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
----------------------
44
HHSearch
48.39
15%
-113
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[41-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
----
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
L
-
P
I
W
-
A
A
S
-
K
-
V
N
----------
G
W
--
I
F
G
T
F
L
C
K
V
V
S
L
L
---
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
-----
R
T
----
L
---
T
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
-
Q
-
A
---
Y
HPNN
S
S
P
V
C
Y
--
E
-
V
L
G
ND-----
T
AKWR-
M
------
V
----
L
R
I
LPHT
F
----
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
----
F
T
L
R
T
L
F
K
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
G
Q
K
H
R
A
M
-
R
V
I
F
A
V
V
L
I
F
L
L
-
C
W
L
P
Y
N
L
----
V
L
L
A
D
---
T
L
M
RTQVIQE
S
C
E
R
R
----
N
N
I
G
R
A
L
D
A
T
---
E
I
L
G
F
L
H
S
C
L
N
P
-------
I
I
Y
A
F
I
G
---------------
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
---------------------------------------------------------------------
33
HHSearch
46.86
10%
-110
* C3 *
3V2Y
1
ENLYS_BPT4
A:
[64-495]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
----
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
-
G
A
T
-----------
T
Y
--
K
L
T
P
A
Q
W
F
L
R
E
G
S
---
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-------------
N
---
N
---
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
W
-
N
C
I
---
S
----
A
L
S
S
C
S
--
T
-
V
L
P
-------
L
YH
K
--
H
------
Y
I
L
F
-
C
-
T
----
T
----
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
----------
R
-
I
DEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA
Y
A
S
R
S
S
E
N
V
A
L
L
-
K
T
V
I
I
V
L
S
V
F
I
A
-
C
W
A
P
L
F
I
----
L
L
L
L
D
---
V
G
------------
C
KVKT
C
D
I
L
F
R
A
E
Y
F
---
L
V
L
A
V
L
N
S
G
T
N
P
-------
I
I
Y
T
L
T
N
---------------
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
---------------------------------------------------------------------
6
PsiBlast_PDB
46.73
34%
-111
- C3 -
4K5Y
4
CRFR1_HUMAN (first)
A:
[286-423]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
C
I
G
W
G
V
P
F
P
I
I
V
A
W
A
I
G
K
-
L
-
Y
---
Y
----
D
N
E
K
C
W
AG
K
-
R
P
G
-------
V
-----
Y
------
T
----
D
-
Y
---------
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
R
----------
A
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
S
E
T
I
Q
A
R
K
A
V
-
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
F
V
N
--------
E
---
V
S
-------------------
R
V
V
F
I
Y
F
N
---
A
F
L
E
S
F
Q
G
F
F
V
S
-------
V
F
A
C
F
L
N
---------------
S
-----------------------------------------------------------------------------------
49
Fugue
44.85
21%
-17
- C2 -
2JOD
-
PACR_HUMAN
A:
[17-122]
---------------------------------
M
G
S
M
A
H
S
D
G
I
F
K
K
E
Q
A
M
C
L
E
K
I
Q
R
A
N
E
L
M
G
F
N
D
-
S
S
P
G
C
P
G
M
W
D
N
I
T
C
W
K
--
P
A
H
V
G
E
M
V
L
V
S
C
P
E
L
F
R
I
F
N
P
D
Q
D
M
G
V
V
S
R
N
C
T
E
D
G
W
S
------
E
P
-------
F
P
H
----------
Y
F
D
A
C
G
F
D
E
Y
E
S
E
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
44.80
11%
-89
- C3 -
1U19
14
OPSD_BOVIN
A:
[41-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
----
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
-
S
L
H
G
----------
Y
F
--
V
F
G
P
T
G
C
N
L
E
G
F
F
---
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-----
S
N
----
F
R
F
G
E
---
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
-
Y
---
I
P
E
G-
M
Q
C
S
C
G
--
I
-
D
Y
Y
TPHEETN
N
E
----
S
------
F
----
V
-
I
----
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
----
V
F
T
V
K
E
A
A
A
----------
Q
-
Q
QE-----------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
T
Q
K
A
E
K
E
V
T
-
R
M
V
I
I
M
V
I
A
F
L
I
-
C
W
L
P
Y
A
G
----
V
A
F
Y
I
F
T
H
Q
G
------------
S
----
D
F
G
P
I
F
M
T
I
P
---
A
F
F
A
K
T
S
A
V
Y
N
P
-------
V
I
Y
I
M
M
N
---------------
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
-
G
D
D
E
-
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
-----
A
---------------------------------------
22
PsiBlast_CBE
43.40
34%
-125
- C3 -
4K5Y
7
CRFR1_HUMAN (first)
B:
[286-423]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
C
I
G
W
G
V
P
F
P
I
I
V
A
W
A
I
G
K
-
L
-
Y
---
Y
----
D
N
E
K
C
W
AG
K
-
R
---------------
Y
------
T
----
D
-
Y
---------
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
R
----------
A
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
S
E
T
I
Q
A
R
K
A
V
-
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
--------------------------------------
V
F
I
Y
F
N
---
A
F
L
E
S
F
Q
G
F
F
V
S
-------
V
F
A
C
F
L
N
---------------
S
-----------------------------------------------------------------------------------