@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LGR5_HUMAN: (2016-01-10 )
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYVWTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPSPAYPVTESCHLSSVAFVPCL
Atome Classification :
(20 SA)
.........10........20..---......30........40........50........60........70..-------......80--.........90........100.......110.......120....-...130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.-......260.......270.......280.......290-........300.......310--.......320.--......330.......340.......350.......360.......--370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.....-..520.......530.......540.......550..--.....560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710...------....720....-...730.......740.......750.......760.......770.......780.......790.......800.......810------.......820.......830.......840.......850.......860-.......870.......880.......890.......900.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDT
S
R
L
G
V
L
L
S
L
P
V
L
L
Q
LATGGS---SPRS
G
V
L
L
RGCPT
H
C
H
CEPDG
R
M
L
L
R
V
DCSDL
G
L
S
ELPS
N
L
S
V
F
T
S
Y
L
D
L
-------
S
M
N
N
I
S
Q
---LLPNP
L
P
S
L
R
F
L
E
E
L
R
LAG
N
A
L
T
YIPK
G
A
F
T
G
L
Y
S
L
K
V
L
M
LQNNQL-RHV
P
T
E
A
L
Q
N
L
R
S
L
Q
S
LRLDANHISYV
P
P
S
C
F
S
G
L
H
S
L
R
H
L
WLDDN
A
L
TE
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
N
K
IHHIP
D
Y
A
FG
N
L
S
S
L
V
V
L
H
LHN
N
R
I
H
S
L
G
K
K
C
F
D
G
L
HS
L
E
T
L
DLNYN
N
L
D
E
F
P
T
A
I
-
R
T
L
S
N
L
K
E
LGFHSN
N
I
RSI
P
E
K
AFVGNP
S
L
I
T
I
H
FYD
N
--
P
I
Q
F
V
G
R
S
A
F
Q
HLPE
L
R
T
L
TL--N
G
A
S
Q
ITEFPD--LTGTANL
E
S
L
T
LT
G
A
Q
I
S
S
L
P
Q
T
V
C
N
QLPN
L
Q
V
L
DL
S
Y
N
L
L
E
DLP
S
--
F
S
V
C
Q
K
L
Q
K
IDLRHN
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
LNLA
W
N
K
I
A
I
IHP
N
A
F
S
T
L
P
S
L
I
K
L
DLSS
N
L
L
S
SFPITGLHG
L
T
H
L
K
LT
G
N
H
A
L
Q
S
L
I
SSENFPE
L
K
V
I
EMP
Y
A
Y
Q
C
C
A
F
G
V
CE
N
A
Y
K
ISNQWNKGDNS
S
M
D
D
L
H
K
KDAGMFQAQ-DER
D
L
E
D
F
L
L
D
F
E
E
D
L
K
A
L
H
SVQCSPSPGP
F
K
P
C
E
H
L
--
L
D
G
W
L
I
R
I
G
V
W
T
I
A
V
L
A
L
T
C
N
A
L
V
T
S
T
V
FRSPL
Y
I
S
P
I
K
L
L
I
G
V
I
A
A
V
N
M
L
T
G
V
S
S
A
V
L
A
G
V
D
A
F
T
F
G
S
F
ARHGAWWENGV
G
C
H
V
I
G
F
L
S
I
FASES
S
V
F
L
L
T
L
A
A
L
ERGF
S
V
K
Y
S
A
K
FETKA
P
F
S
S
L
K
V
I
I
L
L
C
A
L
L
A
L
T
M
A
A
V
PLLGGSKYGASP
L
C
L
PL------PFGEP
S
T
M
G
Y
M
-
V
A
L
I
L
L
N
S
L
C
F
L
M
M
T
I
A
Y
T
K
L
Y
C
NLDKG
D
L
E
N
I
W
D
C
S
M
V
K
H
I
A
L
L
L
F
T
N
C
I
L
NC
P
V
A
F
L
S
F
S
S
L
I
N
L
T
FI
S
P
E
V
I
K
F
I
L
L
V
VVP
L
P
------
A
C
L
N
P
L
L
Y
I
LFNP
H
F
K
E
D
L
V
S
L
R
K
Q
T
Y
V
W
TRSKHP
S
L
M
SINS
D
D
V
E
KQSC-DST
Q
A
L
V
T
F
TSS
S
I
T
Y
DLPPSSVPSPAYPVTESCHLSS
V
A
FVPCL
29
PsiBlast_CBE
94.49
98%
-135
- C2 -
4BSR
2
LGR5_HUMAN
B:
[24-536]
---------------------------------
L
R
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
-------
S
M
N
N
I
S
Q
---
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
-
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
A
I
-
R
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
--
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
L
R
T
L
T
L
--
N
G
A
S
Q
I
T
E
F
P
D
--
L
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
E
D
L
P
S
--
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
S
N
L
L
S
S
F
P
I
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
E
----------------------------------
R
D
L
E
D
F
L
L
D
F
E
E
D
L
K
A
L
H
S
V
Q
C
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
93.82
98%
-134
- C2 -
4BSU
2
LGR5_HUMAN
A:
[24-536]
---------------------------------
L
R
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
-------
S
M
N
N
I
S
Q
---
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
-
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
A
I
-
R
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
--
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
L
R
T
L
T
L
--
N
G
A
S
Q
I
T
E
F
P
D
--
L
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
E
D
L
P
S
--
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
S
N
L
L
S
S
F
P
I
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
----------------------------------------
F
L
L
D
F
E
E
D
L
K
A
L
H
S
V
Q
C
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
93.63
98%
-132
- C2 -
4BSU
1
LGR5_HUMAN
E:
[24-537]
---------------------------------
L
R
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
-------
S
M
N
N
I
S
Q
---
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
-
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
A
I
-
R
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
--
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
L
R
T
L
T
L
--
N
G
A
S
Q
I
T
E
F
P
D
--
L
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
E
D
L
P
S
--
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
S
N
L
L
S
S
F
P
I
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
E
N
-----------------------------------------------------
Q
C
S
P
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
93.41
98%
-134
- C2 -
4BSR
3
LGR5_HUMAN
A:
[21-536]
------------------------------
G
V
L
L
R
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
-------
S
M
N
N
I
S
Q
---
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
-
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
A
I
-
R
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
--
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
L
R
T
L
T
L
--
N
G
A
S
Q
I
T
E
F
P
D
--
L
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
E
D
L
P
S
--
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
S
N
L
L
S
S
F
P
I
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
E
----------------------------------
R
D
L
E
D
F
L
L
D
F
E
E
D
L
K
A
L
H
S
V
Q
C
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
92.69
98%
-134
- C2 -
4BSS
3
LGR5_HUMAN
B:
[21-536]
------------------------------
G
V
L
L
R
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
-------
S
M
N
N
I
S
Q
---
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
-
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
A
I
-
R
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
--
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
L
R
T
L
T
L
--
N
G
A
S
Q
I
T
E
F
P
D
--
L
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
E
D
L
P
S
--
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
S
N
L
L
S
S
F
P
I
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
------------------------------------------------
L
K
A
L
H
S
V
Q
C
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
92.53
100%
-133
- C2 -
4KNG
2
LGR5_HUMAN
B:
[3-517]
----------------------------------
R
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
-------
S
M
N
N
I
S
Q
---
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
-
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
A
I
-
R
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
--
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
L
R
T
L
T
L
--
N
G
A
S
Q
I
T
E
F
P
D
--
L
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
E
D
L
P
S
--
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
S
N
L
L
S
S
F
P
I
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
-------------------------------------------------------
H
S
V
Q
C
S
P
S
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
92.18
98%
-134
- C2 -
4BSU
1
LGR5_HUMAN
B:
[26-536]
-----------------------------------
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
-------
S
M
N
N
I
S
Q
---
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
-
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
A
I
-
R
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
--
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
L
R
T
L
T
L
--
N
G
A
S
Q
I
T
E
F
P
D
--
L
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
E
D
L
P
S
--
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
S
N
L
L
S
S
F
P
I
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
-----------------------------------------
L
L
D
F
E
E
D
L
K
A
L
H
S
V
Q
C
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
92.09
98%
-132
- C2 -
4BSU
2
LGR5_HUMAN
F:
[23-536]
--------------------------------
L
L
R
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
-------
S
M
N
N
I
S
Q
---
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
-
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
A
I
-
R
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
--
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
L
R
T
L
T
L
--
N
G
A
S
Q
I
T
E
F
P
D
--
L
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
E
D
L
P
S
--
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
S
N
L
L
S
S
F
P
I
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
----------------------------------------------------
H
S
V
Q
C
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.89
100%
-130
- C2 -
4KNG
2
LGR5_HUMAN
A:
[3-514]
----------------------------------
R
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
-------
S
M
N
N
I
S
Q
---
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
-
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
A
I
-
R
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
--
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
L
R
T
L
T
L
--
N
G
A
S
Q
I
T
E
F
P
D
--
L
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
E
D
L
P
S
--
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
S
N
L
L
S
S
F
P
I
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
------------------------------------------------------
H
S
V
Q
C
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
91.04
98%
-131
- C2 -
4BST
2
LGR5_HUMAN
B:
[26-536]
-----------------------------------
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
-------
S
M
N
N
I
S
Q
---
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
-
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
A
I
-
R
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
--
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
L
R
T
L
T
L
--
N
G
A
S
Q
I
T
E
F
P
D
--
L
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
E
D
L
P
S
--
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
S
N
L
L
S
S
F
P
I
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
------------------------------------------------------
V
Q
C
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
90.78
98%
-135
- C2 -
4BSS
2
LGR5_HUMAN
A:
[26-536]
-----------------------------------
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
-------
S
M
N
N
I
S
Q
---
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
-
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
A
I
-
R
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
--
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
L
R
T
L
T
L
--
N
G
A
S
Q
I
T
E
F
P
D
--
L
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
E
D
L
P
S
--
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
S
N
L
L
S
S
F
P
I
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
----------------------------------------------
E
E
D
L
K
A
L
H
S
V
Q
C
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
90.62
98%
-130
- C2 -
4BSS
1
LGR5_HUMAN
F:
[26-536]
-----------------------------------
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
-------
S
M
N
N
I
S
Q
---
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
-
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
A
I
-
R
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
--
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
L
R
T
L
T
L
--
N
G
A
S
Q
I
T
E
F
P
D
--
L
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
E
D
L
P
S
--
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
S
N
L
L
S
S
F
P
I
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
------------------------------------------------
L
K
A
L
H
S
V
Q
C
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
90.39
98%
-129
- C2 -
4BSS
2
LGR5_HUMAN
E:
[26-536]
-----------------------------------
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
-------
S
M
N
N
I
S
Q
---
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
-
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
A
I
-
R
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
--
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
L
R
T
L
T
L
--
N
G
A
S
Q
I
T
E
F
P
D
--
L
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
E
D
L
P
S
--
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
S
N
L
L
S
S
F
P
I
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
E
--------------------------------------------
E
E
D
L
K
A
L
H
S
V
Q
C
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
90.09
98%
-132
- C2 -
4BST
3
LGR5_HUMAN
A:
[26-536]
-----------------------------------
G
C
P
T
H
C
H
C
E
P
D
G
R
M
L
L
R
V
D
C
S
D
L
G
L
S
E
L
P
S
N
L
S
V
F
T
S
Y
L
D
L
-------
S
M
N
N
I
S
Q
---
L
L
P
N
P
L
P
S
L
R
F
L
E
E
L
R
L
A
G
N
A
L
T
Y
I
P
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
-
R
H
V
P
T
E
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
N
H
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
N
K
I
H
H
I
P
D
Y
A
F
G
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
S
L
G
K
K
C
F
D
G
L
H
S
L
E
T
L
D
L
N
Y
N
N
L
D
E
F
P
T
A
I
-
R
T
L
S
N
L
K
E
L
G
F
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
P
S
L
I
T
I
H
F
Y
D
N
--
P
I
Q
F
V
G
R
S
A
F
Q
H
L
P
E
L
R
T
L
T
L
--
N
G
A
S
Q
I
T
E
F
P
D
--
L
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
E
D
L
P
S
--
F
S
V
C
Q
K
L
Q
K
I
D
L
R
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
I
A
I
I
H
P
N
A
F
S
T
L
P
S
L
I
K
L
D
L
S
S
N
L
L
S
S
F
P
I
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
-------------------------------------------------------
V
Q
C
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
79.90
53%
-137
- C2 -
4KT1
2
LGR4_HUMAN
A:
[4-502]
------------------------------------
C
A
A
P
C
S
C
D
G
D
----
R
R
V
D
C
S
G
K
G
L
T
A
V
P
E
G
L
S
A
F
T
Q
A
L
D
I
-------
S
M
N
N
I
T
Q
---
L
P
E
D
A
F
K
N
F
P
F
L
E
E
L
Q
L
A
G
N
D
L
S
F
I
H
P
K
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
Q
L
-
K
T
V
P
S
E
A
I
R
G
L
S
A
L
Q
S
L
R
L
D
A
N
H
I
T
S
V
P
E
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
T
E
V
P
V
H
P
L
S
N
L
P
T
L
Q
A
L
T
L
A
L
N
K
I
S
S
I
P
D
F
A
F
T
N
L
S
S
L
V
V
L
H
L
H
N
N
K
I
R
S
L
S
Q
H
C
F
D
G
L
D
N
L
E
T
L
D
L
N
Y
N
N
L
G
E
F
P
Q
A
I
-
K
A
L
P
S
L
K
E
L
G
F
H
S
N
S
I
S
V
I
P
D
G
A
F
D
G
N
P
L
L
R
T
I
H
L
Y
D
N
--
P
L
S
F
V
G
N
S
A
F
H
N
L
S
D
L
H
S
L
V
I
--
R
G
A
S
M
V
Q
Q
F
P
N
--
L
T
G
T
V
H
L
E
S
L
T
L
T
G
T
K
I
S
S
I
P
N
N
L
C
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
N
I
R
D
L
P
S
--
F
N
G
C
H
A
L
E
E
I
S
L
Q
R
N
Q
I
Y
Q
I
K
E
G
T
F
Q
G
L
I
S
L
R
I
L
D
L
S
R
N
L
I
H
E
I
H
S
R
A
F
A
T
L
G
P
I
T
N
L
D
V
S
F
N
E
L
T
S
F
P
T
E
G
L
N
G
L
N
Q
L
K
L
V
G
N
F
K
L
K
E
A
L
A
A
K
D
F
V
N
L
R
S
L
S
V
P
Y
A
Y
Q
C
C
A
F
W
G
C
------------------------------------------------------
I
H
C
T
P
S
T
G
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.58
59%
-118
- C2 -
4LI2
-
LGR4_XENTR
A:
[21-424]
----------------------------------------------------
A
D
C
S
G
K
G
L
V
T
V
P
D
G
L
S
V
F
T
H
S
L
D
L
-------
S
M
N
N
I
T
K
---
L
P
E
G
A
F
K
G
F
P
Y
L
E
E
L
R
L
A
G
N
D
L
S
I
I
H
P
M
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
Q
L
-
K
T
V
P
S
E
S
L
K
G
L
V
S
L
Q
S
L
R
L
D
A
N
H
I
V
T
V
P
E
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
T
E
V
P
I
R
P
L
S
N
L
P
S
L
Q
A
L
T
L
A
L
N
K
I
S
H
I
P
D
Y
A
F
S
N
L
S
S
L
V
V
L
H
L
H
N
N
K
I
R
T
L
G
P
H
S
F
H
G
L
D
N
L
E
A
L
D
L
N
Y
N
N
L
I
D
F
P
D
S
I
-
R
S
L
P
N
L
K
E
L
G
F
H
S
N
S
I
T
I
I
P
D
G
A
F
V
K
N
P
L
L
R
T
I
H
L
Y
D
N
--
P
L
S
F
V
G
N
S
A
F
Q
N
L
S
D
L
H
F
L
I
I
--
R
G
A
S
N
V
Q
W
F
P
N
--
L
T
G
T
N
N
L
E
S
L
T
L
T
G
T
K
I
R
S
I
P
I
K
F
C
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
E
I
S
A
L
V
G
--
F
E
G
C
S
S
L
E
E
V
Y
L
Q
N
N
Q
I
Q
E
V
Q
N
E
T
F
Q
G
L
A
A
L
R
M
L
D
L
S
R
N
R
I
H
T
I
H
K
E
A
F
V
T
L
K
A
L
T
N
L
D
L
S
F
N
D
L
T
A
F
P
T
A
G
L
H
G
L
N
Q
L
K
L
T
G
N
P
N
F
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.59
59%
-126
- C2 -
4LI1
2
LGR4_XENTR
B:
[21-424]
----------------------------------------------------
A
D
C
S
G
K
G
L
V
T
V
P
D
G
L
S
V
F
T
H
S
L
D
L
-------
S
M
N
N
I
T
K
---
L
P
E
G
A
F
K
G
F
P
Y
L
E
E
L
R
L
A
G
N
D
L
S
I
I
H
P
M
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
Q
L
-
K
T
V
P
S
E
S
L
K
G
L
V
S
L
Q
S
L
R
L
D
A
N
H
I
V
T
V
P
E
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
T
E
V
P
I
R
P
L
S
N
L
P
S
L
Q
A
L
T
L
A
L
N
K
I
S
H
I
P
D
Y
A
F
S
N
L
S
S
L
V
V
L
H
L
H
N
N
K
I
R
T
L
G
P
H
C
F
H
G
L
D
N
L
E
A
L
D
L
N
Y
N
N
L
I
D
F
P
D
S
I
-
R
S
L
P
N
L
K
E
L
G
F
H
S
N
S
I
T
I
I
P
D
G
A
F
V
K
N
P
L
L
R
T
I
H
L
Y
D
N
--
P
L
S
F
V
G
N
S
A
F
Q
N
L
S
D
L
H
F
L
I
I
--
R
G
A
S
N
V
Q
W
F
P
N
--
L
T
G
T
N
N
L
E
S
L
T
L
T
G
T
K
I
R
S
I
P
I
K
F
C
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
E
I
S
A
L
V
G
--
F
E
G
C
S
S
L
E
E
V
Y
L
Q
N
N
Q
I
Q
E
V
Q
N
E
T
F
Q
G
L
A
A
L
R
M
L
D
L
S
R
N
R
I
H
T
I
H
K
E
A
F
V
T
L
K
A
L
T
N
L
D
L
S
F
N
D
L
T
A
F
P
T
A
G
L
H
G
L
N
Q
L
K
L
T
G
N
P
N
F
K
E
T
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.05
58%
-129
- C2 -
4QXE
7
LGR4_HUMAN
A:
[5-399]
------------------------------------
C
A
A
P
C
S
C
D
G
D
----
R
R
V
D
C
S
G
K
G
L
T
A
V
P
E
G
L
S
A
F
T
Q
A
L
D
I
-------
S
M
N
N
I
T
Q
---
L
P
E
G
A
F
K
N
F
P
F
L
E
E
L
Q
L
A
G
N
D
L
S
F
I
H
P
K
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
Q
L
-
K
T
V
P
S
E
A
I
R
G
L
S
A
L
Q
S
L
R
L
D
A
N
H
I
T
S
V
P
E
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
T
E
V
P
V
H
P
L
S
N
L
P
T
L
Q
A
L
T
L
A
L
N
K
I
S
S
I
P
D
F
A
F
T
N
L
S
S
L
V
V
L
H
L
H
N
N
K
I
R
S
L
S
Q
H
C
F
D
G
L
D
N
L
E
T
L
D
L
N
Y
N
N
L
G
E
F
P
Q
A
I
-
K
A
L
P
S
L
K
E
L
G
F
H
S
N
S
I
S
V
I
P
D
G
A
F
D
G
N
P
L
L
R
T
I
H
L
Y
D
N
--
P
L
S
F
V
G
N
S
A
F
H
N
L
S
D
L
H
S
L
V
I
--
R
G
A
S
M
V
Q
Q
F
P
N
--
L
T
G
T
V
H
L
E
S
L
T
L
T
G
T
K
I
S
S
I
P
N
N
L
C
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
N
I
R
D
L
P
S
--
F
N
G
C
H
A
L
E
E
I
S
L
Q
R
N
Q
I
Y
Q
I
K
E
G
T
F
Q
G
L
I
S
L
R
I
L
D
L
A
S
N
Q
L
K
S
V
P
D
G
I
F
D
R
L
T
S
L
Q
K
I
W
L
H
T
N
P
W
D
C
S
C
P
R
I
D
Y
L
S
R
W
L
N
K
N
S
Q
K
E
Q
G
S
A
K
C
S
G
S
G
K
P
V
R
S
I
I
C
P
T
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Fugue
65.00
21%
-120
- C1 -
4LXR
11
TOLL_DROME
A:
[1-773]
--------
S
F
G
R
D
A
C
S
E
M
S
I
D
G
L
C
Q
C
A
P
I
M
S
E
Y
E
I
I
C
P
A
N
-----
A
E
N
P
T
F
R
L
T
I
Q
P
K
D
Y
V
Q
I
M
C
N
L
T
D
T
T
D
Y
Q
Q
L
PKKLRIG
E
V
D
R
V
Q
M
R
RC
M
L
P
G
H
T
P
I
A
S
I
L
D
Y
L
----------------
G
I
V
S
P
T
T
L
I
F
E
S
D
N
L
G
M
N
I
T
R
Q
H
L
D
R
L
H
G
L
K
R
F
R
F
T
T
R
R
L
T
H
I
P
A
N
L
L
T
D
M
R
N
L
S
H
L
E
L
R
A
N
-
I
E
E
M
P
S
H
L
F
D
D
L
E
N
L
E
S
I
E
F
G
S
N
K
L
R
Q
M
P
R
G
I
F
G
K
M
P
K
L
K
Q
L
N
L
W
S
N
Q
L
H
N
L
T
K
H
D
F
E
G
A
T
S
V
L
G
I
D
I
H
D
N
G
I
E
Q
L
P
H
D
V
F
A
H
L
T
N
V
T
D
I
N
L
S
A
N
L
F
R
S
L
P
Q
G
L
F
D
H
N
K
H
L
N
E
V
R
L
M
N
N
RV
P
L
A
T
L
P
S
R
L
F
A
N
Q
P
E
L
Q
I
L
R
L
--
R
--
A
E
L
Q
S
L
P
G
DL
F
E
H
S
T
Q
I
T
N
I
S
L
G
D
N
L
L
K
T
L
P
A
T
L
L
E
H
Q
V
N
L
L
S
L
D
L
S
N
N
R
L
T
H
L
P
D
SL
F
A
H
T
T
N
L
T
D
L
R
L
E
D
N
L
L
T
G
I
S
G
D
I
F
S
N
L
G
N
L
V
T
L
V
M
S
R
N
R
L
R
T
I
D
S
R
A
F
---------------------
V
S
T
N
G
L
R
H
L
H
L
D
H
N
D
I
------
D
L
Q
Q
P
L
L
D
I
M
L
-----------------------
Q
T
Q
I
N
S
P
F
G
Y
M
H
----
G
L
L
T
L
N
L
R
N
N
S
I
I
F
V
Y
N
D
W
K
N
T
M
L
Q
L
R
E
L
D
L
S
Y
N
N
I
S
S
L
G
Y
E
D
L
AF
L
S
Q
N
R
L
H
V
N
M
T
H
N
K
I
R
R
I
A
L
P
E
D
V
N
N
N
L
V
H
V
D
L
N
D
N
P
L
V
C
D
C
T
I
L
W
F
I
Q
L
V
R
G
V
H
K
P
Q
Y
S
R
Q
F
K
L
R
T
D
R
L
V
C
S
Q
P
N
V
L
E
G
T
P
V
R
Q
I
E
------
P
Q
T
L
I
C
P
L
D
F
S
K
C
P
R
G
C
N
C
H
V
R
---------
T
Y
D
K
A
L
V
I
N
C
--
H
S
G
N
L
T
H
V
P
R
L
P
N
L
H
K
N
M
Q
L
M
E
L
H
L
ENNTLL
R
L
P
S
A
N
T
P
G
Y
E
S
V
T
S
L
H
L
A
G
--
N
N
L
T
S
I
D
V
D
Q
L
P
T
N
L
T
H
L
D
I
--------------------------------
S
W
N
H
L
Q
M
L
N
A
T
V
L
G
F
L
N
W
R
S
V
K
L
S
GNPWMC
D
C
T
A
K
P
L
L
L
F
T
Q
D
N
F
E
------------------------
R
I
G
D
R
N
E
M
M
C
V
N
A
P
T
R
M
V
E
L
S
T
N
D
I
-----------------------------
C
P
36
PsiBlast_CBE
64.16
34%
-129
- C2 -
4R5C
2
?
A:
[61-299]
--------------------------------------------------------------------------------------------------
L
P
N
V
R
Y
L
A
---
L
G
G
N
K
L
H
D
I
S
--
A
L
K
E
L
T
N
L
G
W
L
N
L
S
N
N
Q
L
-
E
T
L
P
Q
G
V
F
E
K
L
T
N
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
G
V
F
E
R
L
A
S
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
G
V
F
E
R
L
T
N
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
G
V
F
E
R
L
T
N
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
G
V
F
E
R
L
T
S
L
H
T
L
D
L
S
N
N
G
I
T
D
I
-
S
A
L
-
K
N
L
D
N
L
H
T
L
D
L
S
N
N
G
I
T
D
I
S
A
L
K
N
L
D
N
--
L
H
T
L
D
L
S
N
N
--
G
I
T
D
I
--
S
A
L
K
N
L
T
S
L
H
T
L
D
L
SN
N
G
I
T
D
I
S
A
L
K
N
--
L
---
D
N
L
E
T
L
D
L
R
N
N
G
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------