@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NPY4R_HUMAN: (2016-01-11 )
MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSILENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRRLQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTEVSKGSLRLSGRSNPI
Atome Classification :
(20 SA)
.........10........20........30........--40........50........60........70........80........90...-.....100..-.....110.......120.......130.......140......-.150-.-----.......160--.......170..--.....-.180.......190.......200...--...-.---210.......220.......230.......240.......------------------------------------250--------.---------------------------------------------------------------------------------------------------------------------------------------------------------.-----------------.......260---......--...270........280...-----...---.290..-----.-....300---........310.......320.......330.......340.......350.......360.......370...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNT
S
H
L
L
A
L
LLPKSPQGENRSKPLGTPY
N
F
S
E
H
C
QDSV
D
--
V
M
V
F
I
V
TSY
S
I
E
T
V
V
G
V
L
G
N
L
C
L
M
C
VTVRQKEKAN
V
T
N
L
L
I
A
N
L
A
F
S
D
F
L
M
C
L
L
C-
Q
P
L
T
A
V
Y
T
I
M
-
D
Y
W
I
F
G
E
T
L
C
K
M
S
A
F
I
Q
C
M
S
V
T
V
S
I
L
S
L
V
L
V
A
LER
H
Q
L
I
INPTG-WKP--
S
-----
I
S
Q
A
Y
L
G
I
V
L
--
I
W
V
I
A
C
V
L
S
-
L
P
--
F
L
A
N
S
-
I
L
E
N
V
F
HK
N
H
S
K
A
L
E
F
L
A
DK
V
V
CTESW--PLA-
H
---
H
R
T
I
Y
T
T
F
L
L
L
F
Q
Y
C
L
P
L
G
F
I
L
V
C
Y
A
R
I
Y
R
R
L
Q
RQG
R
V
F
H------------------------------------K----------G---------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----------------
Y
S
LRAGH
M
-----
K
Q
V
N
V
V
--
L
V
V
M
V
-
V
A
F
A
V
L
W
L
P
L
H
V
F
N
-----
S
L
E
---
D
W
H
HEA-----I-PICHG
N
----
L
I
F
L
V
C
H
L
L
A
M
A
S
T
C
V
N
P
F
I
Y
G
F
LNT
N
F
K
K
E
I
K
A
L
V
L
TCQQSAPLEESEHLPL
S
T
V
H
T
EVSKG
S
L
R
LSGRSNPI
41
Fugue
89.29
26%
-151
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------------------------------
S
F
K
C
A
L
T
K
T
GF
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
-
P
A
L
I
F
Y
Y
F
N
K
-
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
G
R
L
--
K
-----
K
K
N
A
I
C
I
S
V
L
--
V
W
L
I
V
V
V
A
I
-
S
P
--
I
L
F
Y
S
---
G
T
G
V
R
K
N
K
T
---------
I
T
C
Y
D
T
T
SD
E
Y
L
-
R
---
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVG
K
----------
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----------------
F
E
E
V
E
E
P
L
-----
R
R
K
S
I
Y
--
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
-----
T
M
N
L
R
A
R
L
D
F
Q
T
-----
P
-
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
-------------------------------------------
24
HHSearch
89.06
21%
-154
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-442]
---------------------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
-
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
-
Y
L
K
YR
T
-----
K
T
R
A
S
A
T
I
L
G
--
A
W
F
L
S
F
L
W
V
-
I
P
--
I
L
G
W
N
-
H
----------------
R
R
E
D
K
C
E
T
D
F
--
Y
D
V
-------
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
------------------------------------
M
----------
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
-------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD
A
Y
L
H
M
N
R
E
-----
R
K
A
A
K
Q
--
L
G
F
I
M
-
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
-----
M
V
I
---
A
F
C
K
N
C
-----
C
-
N
----
E
----
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
------------------------------------
26
HHSearch
88.62
23%
-145
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[47-495]
-----------------------------------------
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
-
S
Q
R
P
R
K
-----
L
L
A
E
K
V
V
Y
V
G
--
V
W
I
P
A
L
L
L
T
-
I
P
--
D
F
I
F
A
-
N
V
S
E
------------
A
D
D
R
Y
I
C
D
R
F
Y
--
P
N
D
-
L
---
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
------------------------------------
E
----------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD
A
-----------------
Y
G
S
K
G
H
Q
K
-----
R
K
A
L
K
T
--
T
V
I
L
I
-
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
-----
S
I
D
---
S
F
I
L
L
E
I
I
K
Q
G
C
E
F
E
N
T
V
H
----
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
---------------------------
27
HHSearch
83.87
21%
-151
- C2 -
3EML
13
ENLYS_BPT4
A:
[23-468]
--------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
---
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
-
Y
N
G
L
V
T
-----
G
T
R
A
K
G
I
I
A
I
--
C
W
V
L
S
F
A
I
G
-
L
T
--
P
M
L
G
W
N
N
C
G
Q
--------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
--
V
V
------
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
------------------------------------
M
----------
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
-
A
-----------------
Y
R
S
T
L
Q
K
E
-----
V
H
A
A
K
S
--
L
A
I
I
V
-
G
L
F
A
L
C
W
L
P
L
H
I
I
N
-----
C
F
T
---
F
F
C
P
D
C
-----
S
---
H
A
P
L
----
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-------------------------------
31
HHSearch
83.69
20%
-152
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-332]
-----------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
-
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
-
A
S
K
K
M
S
-----
H
R
R
A
F
I
M
I
I
F
--
V
W
L
W
S
V
L
W
A
-
I
G
--
P
I
F
G
W
-
G
A
Y
T
L
-----------
E
G
V
L
C
N
C
S
F
D
Y
--
I
S
R
D
S
---
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
------------------------------------
A
M
A
K
RLNAKE
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----------------
A
Q
A
G
A
N
A
E
-----
M
R
L
A
K
I
--
S
I
V
I
V
-
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
-----
L
L
A
---
Q
F
G
P
L
E
-----
W
----
V
T
P
----
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
----------
21
HHSearch
83.50
20%
-140
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
--------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
I
-
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
-
Y
P
V
KR
T
-----
T
K
M
A
G
M
M
I
A
A
--
A
W
V
L
S
F
I
L
W
-
A
P
--
A
I
L
F
W
-
Q
F
I
V
G
V
R
---------
T
V
E
D
G
E
C
Y
I
Q
F
--
F
S
-------
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
------------------------------------
M
----------
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--
D
-----------------
A
Y
P
P
P
S
R
E
-----
K
K
V
T
R
T
--
I
L
A
I
L
-
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
-----
L
I
N
---
T
F
C
A
P
C
-----
I
-----
P
N
----
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-------------------------------------
29
HHSearch
83.09
23%
-143
* C2 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-471]
---------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
-
Y
Q
H
--
G
T
G
Q
SS
C
R
R
V
A
L
M
I
T
A
--
V
W
V
L
A
F
A
V
S
-
C
P
--
L
L
F
G
F
-
N
T
T
--------------
G
D
P
T
V
C
S
I
S
N
--
P
----------
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
------------------------------------
F
----------
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTW
D
-----------------
A
Y
G
V
P
L
R
E
-----
K
K
A
T
Q
M
--
V
A
I
V
L
-
G
A
F
I
V
C
W
L
P
F
F
L
T
H
-----
V
L
N
---
T
H
C
Q
T
C
-----
H
----
V
S
P
----
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
------------------------------------
17
PsiBlast_PDB
83.01
23%
-180
- C2 -
2Y02
13
ADRB1_MELGA
A:
[26-299]
---------------------------------------------------------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
-
Y
Q
S
--
L
-----
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
------
F
V
-
T
---
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
--
G
I
I
M
G
-
V
-
F
T
L
C
W
L
P
F
F
L
V
N
-----
I
V
N
---
V
F
N
R
D
L
-----
V
-
P
----
D
----
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------
2
PsiBlast_PDB
82.96
26%
-151
- C2 -
4EA3
3
C562_ECOLX (first)
A:
[126-405]
-------------------------------------------
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
-
L
L
T
-
L
P
F
Q
G
T
D
I
L
L
-
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
--------
T
-----
S
S
K
A
Q
A
V
N
V
A
--
I
W
A
L
A
S
V
V
G
-
V
P
V
A
I
M
G
S
A
-
Q
V
E
D
-------
E
E
I
E
C
L
V
E
I
P
T
P
Q
D
Y
W
-----------
G
P
V
F
A
I
C
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
-
R
G
V
R
L
L
S
------------------------------------
G
----------
S
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------
E
K
D
R
--
N
L
-----
R
R
I
T
R
L
--
V
L
V
V
V
-
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
Q
G
L
G
V
Q
---
P
S
S
E
T
A
-----
V
-
A
I
L
R
----------
F
C
T
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
-----------------------------------------
9
PsiBlast_PDB
82.75
23%
-165
- C2 -
2YCZ
2
ADRB1_MELGA
A:
[26-297]
---------------------------------------------------------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
-
Y
Q
S
--
L
-----
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
------
F
V
-
T
---
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
------------------------------------
R
----------
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------
K
R
K
R
V
M
L
M
-----
R
E
H
K
A
L
K
T
L
G
I
I
M
-
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-----
I
V
N
---
V
F
N
R
D
L
-----
V
-
P
----
D
----
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
------------------------------------
18
PsiBlast_PDB
82.70
23%
-177
- C2 -
2Y03
9
ADRB1_MELGA
A:
[26-299]
---------------------------------------------------------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
-
Y
Q
S
--
L
-----
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
------
F
V
-
T
---
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
--
G
I
I
M
G
-
V
-
F
T
L
C
W
L
P
F
F
L
V
N
-----
I
V
N
---
V
F
N
R
D
L
-----
V
-
P
----
D
----
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------
19
PsiBlast_PDB
82.58
23%
-176
- C2 -
2Y04
13
ADRB1_MELGA
A:
[26-299]
---------------------------------------------------------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
-
Y
Q
S
--
L
-----
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
------
F
V
-
T
---
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
--
G
I
I
M
G
-
V
-
F
T
L
C
W
L
P
F
F
L
V
N
-----
I
V
N
---
V
F
N
R
D
L
-----
V
-
P
----
D
----
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------
15
PsiBlast_PDB
82.47
23%
-178
- C2 -
2Y00
13
ADRB1_MELGA
A:
[26-299]
---------------------------------------------------------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
-
Y
Q
S
--
L
-----
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
------
F
V
-
T
---
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
--
G
I
I
M
G
-
V
-
F
T
L
C
W
L
P
F
F
L
V
N
-----
I
V
N
---
V
F
N
R
D
L
-----
V
-
P
----
D
----
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------
23
HHSearch
81.97
28%
-139
- C2 -
2KS9
1
NK1R_HUMAN
A:
[35-324]
---------------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
-
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
-
P
R
L
--
S
-----
A
T
A
T
K
V
V
I
C
V
--
I
W
V
L
A
L
L
L
A
-
F
P
--
Q
G
Y
Y
S
-
T
T
E
T
--
M
----------
P
S
R
V
V
C
M
I
E
W
--
P
E
H
-
P
NKI
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
------------------------------------
S
----------
S
D--------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------
Y
H
E
Q
V
S
A
K
-----
R
K
V
V
K
M
--
M
I
V
V
V
-
C
T
F
A
I
C
W
L
P
F
H
I
F
F
-----
L
L
P
---
Y
I
N
P
D
L
-----
Y
-
L
K
K
F
I
Q
----
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
25
HHSearch
81.45
20%
-145
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-476]
-------------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
-
Y
Q
S
--
L
LT---
K
N
K
A
R
V
I
I
L
M
--
V
W
I
V
S
G
L
T
S
-
F
L
--
P
I
Q
M
H
-
W
Y
R
A
T
H
Q
E
-
A
I
N
C
----
Y
A
E
E
T
C
C
D
F
F
--
T
--------
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
------------------------------------
M
----------
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--
D
-----------------
A
Y
K
F
C
L
K
E
-----
H
K
A
L
K
T
--
L
G
I
I
M
-
G
T
F
T
L
C
W
L
P
F
F
I
V
N
-----
I
V
H
---
V
I
Q
D
N
L
-----
I
-----
R
K
----
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------------
7
PsiBlast_PDB
81.42
23%
-161
- C2 -
2YCW
7
ADRB1_MELGA
A:
[26-297]
---------------------------------------------------------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
-
Y
Q
S
--
L
-----
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
------
F
V
-
T
---
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
------------------------------------
R
----------
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------
K
R
K
R
V
M
L
M
-----
R
E
H
K
A
L
K
T
L
G
I
I
M
-
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-----
I
V
N
---
V
F
N
R
D
L
-----
V
-
P
----
D
----
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
------------------------------------
20
PsiBlast_PDB
81.31
23%
-173
- C2 -
4AMJ
12
ADRB1_MELGA
A:
[26-299]
---------------------------------------------------------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
-
Y
Q
S
--
L
-----
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
------
F
V
-
T
---
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
--
G
I
I
M
G
-
V
-
F
T
L
C
W
L
P
F
F
L
V
N
-----
I
V
N
---
V
F
N
R
D
L
-----
V
-
P
----
D
----
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------
16
PsiBlast_PDB
81.09
23%
-179
- C2 -
2Y01
12
ADRB1_MELGA
A:
[26-299]
---------------------------------------------------------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
-
Y
Q
S
--
L
-----
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
------
F
V
-
T
---
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
--
G
I
I
M
G
-
V
-
F
T
L
C
W
L
P
F
F
L
V
N
-----
I
V
N
---
V
F
N
R
D
L
-----
V
-
P
----
D
----
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------
10
PsiBlast_PDB
81.03
23%
-165
- C2 -
2YCY
6
ADRB1_MELGA
A:
[26-297]
---------------------------------------------------------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
-
Y
Q
S
--
L
-----
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
------
F
V
-
T
---
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
--
D
------------------------------------
R
----------
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------
K
R
K
R
V
M
L
M
-----
R
E
H
K
A
L
K
T
L
G
I
I
M
-
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-----
I
V
N
---
V
F
N
R
D
L
-----
V
-
P
----
D
----
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
------------------------------------
8
PsiBlast_PDB
80.76
23%
-160
- C2 -
2YCX
3
ADRB1_MELGA
A:
[26-294]
---------------------------------------------------------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
-
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
-
Y
Q
S
--
L
-----
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
--------
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
------
F
V
-
T
---
N
R
A
-
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
------------------------------------
R
----------
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------
K
R
K
R
V
M
L
M
-----
R
E
H
K
A
L
K
T
L
G
I
I
M
-
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-----
I
V
N
---
V
F
N
R
D
L
-----
V
-
P
----
D
----
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
-----------------------------------------