@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10G4_HUMAN: (2016-01-11 )
MSNASLVTAFILTGLPHAPGLDALLFGIFLVVYVLTVLGNLLILLVIRVDSHLHTPMYYFLTNLSFIDMWFSTVTVPKMLMTLVSPSGRAISFHSCVAQLYFFHFLGSTECFLYTVMSYDRYLAISYPLRYTSMMSGSRCALLATGTWLSGSLHSAVQTILTFHLPYCGPNQIQHYFCDAPPILKLACADTSANVMVIFVDIGIVASGCFVLIVLSYVSIVCSILRIRTSDGRRRAFQTCASHCIVVLCFFVPCVVIYLRPGSMDAMDGVVAIFYTVLTPLLNPVVYTLRNKEVKKAVLKLRDKVAHPQRK
Atome Classification :
(20 SA)
-------------.........10......---------------.--.20........30........40........50........60........70....-....80........90........100.......110.......120.......130.......140......----------.150...-....160....-----.-----..170.......180.......190--.......200.......210.......220....-.--------..230------------------.--------.......--.240.......250...-----....260---.-------.---------.-----..-----------..270.......280.......290.......300-----------------........310-------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------MSN
A
S
L
V
T
A
F
I
L
TGLPH---------------A--P
G
L
D
A
L
L
F
G
I
F
L
V
V
Y
V
L
T
V
L
G
N
L
L
I
L
L
V
I
RVDSHLH
T
P
M
Y
Y
F
L
TN
L
S
F
I
D
M
W
F
S
TV
T
-
V
P
K
M
L
M
T
L
VSPSG
R
A
I
S
F
H
S
C
V
A
Q
L
Y
F
F
H
F
LGST
E
C
F
L
Y
T
VMSYD
R
Y
L
A
I
SY
P
L
R
Y
T
SMMSGS
R
C
A
L
L
ATGTW----------LS
G
S
L
H
S
-
A
V
Q
T
I
L
T
FHLP-----Y-----CG
P
N
Q
I
Q
H
YFCDAP
P
I
L
K
L
A
CADTS--A
N
V
M
V
I
F
V
D
I
G
I
VAS
G
C
F
V
L
I
V
L
S
Y
V
S
I
V
C
S
I
L
R
-I--------RTS--------------------D--------G
R
R
R
A
F
Q
--
T
C
A
S
H
C
I
V
V
L
C
F
F
V
P
C
V
-----
V
I
Y
LRPG---S-------
M
---------
D
-----
A
M
-----------
D
G
V
V
A
I
F
Y
T
V
L
T
P
L
L
N
P
V
V
Y
T
LR
N
K
E
V
K
K
A
V
L
K
L
------------------
R
D
K
VAHPQRK--------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
85.36
15%
-139
- C1 -
2KS9
1
NK1R_HUMAN
A:
[33-324]
----------------------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
-
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
----------
V
L
A
L
L
L
A
-
F
P
Q
G
Y
Y
S
T
T
E
---------------
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
---
N
K
I
--
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
-
S
--------
E
I
P
GDSSDRYH
E
Q
V
---------
S
--------
A
K
R
K
V
V
K
--
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
-----
I
F
F
L
L
P
Y
---
I
NPD----
L
YL-------
K
KFI--
Q
Q
-----------
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
------------------
F
R
C
C
P
F
I
S
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
85.06
18%
-137
- C1 -
2Z73
5
OPSD_TODPA
A:
[32-334]
-------------------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
-
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
----------
L
W
S
V
L
W
A
-
I
G
P
I
F
G
W
G
A
Y
T
--------------
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
-----
R
D
S
--
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
-
H
--------
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
--------
A
E
M
R
L
A
K
--
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
-----
V
V
A
L
L
A
Q
---
F
-------
G
PLEWV----
T
-----
P
Y
-----------
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
------------------
F
P
W
V
L
T
C
C
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
80.99
16%
-131
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPF
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
---------------
L
AE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
--
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
----------
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
-----
E
GMQC
S
C
G
I
D
----
Y
Y
T
P
H
E
E
T
------
N
N
E
--
S
F
V
I
Y
M
F
V
V
H
---
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-
A
--------
A
A
S
--------------------
A
--------
T
T
Q
K
A
E
K
--
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
-----
L
P
Y
A
G
V
A
---
F
-------
Y
I
F
T
H
QGSDF
G
-----
P
I
-----------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
------------------
L
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A--------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
77.31
16%
-134
- C1 -
1U19
14
OPSD_BOVIN
A:
[37-328]
------------------------------------------------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
----------
V
M
A
L
A
C
A
-
A
P
P
L
V
G
W
S
R
Y
-------------
I
P
-
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
E
E
T
--
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-
A
--------
A
A
Q
--------------------
Q
QESA
T
T
Q
K
A
E
K
E
V
T
R
--
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
-----
G
V
A
F
Y
I
F
T
H
-
Q
-------
G
SDF------
G
-----
P
I
-----------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
------------------
L
C
C
G
K
N
P
L
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
76.94
15%
-123
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYLA
E
--
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
--
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
----------
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
-----
C
G
I
D
----
Y
Y
T
P
H
E
E
T
------
N
N
E
--
S
F
V
I
Y
M
F
V
V
H
F
---
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-
A
AAQQQESA
T
T
Q
--------------------
K
--------
A
E
K
E
V
T
R
--
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
---
D
-------
F
---------
G
-----
P
I
-----------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
74.99
16%
-133
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[35-322]
---------------------------------------------
E
--
T
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
-
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
----------
G
L
S
M
N
L
S
-
L
P
F
F
L
F
R
Q
A
Y
-------------
H
P
-
N
N
S
S
P
V
C
Y
E
V
L
G
N
----
D
T
A
K
--
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
-
A
--------
H
-
M
--------------------
G
--------
Q
K
H
R
A
M
R
--
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
-----
L
V
L
L
A
D
T
L
M
-
R
TQVIQE
S
C
---------
E
R
R
N
N
I
G
R
-----------
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
------------------
L
A
M
H
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
74.12
17%
-111
- C1 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
-----------------------
P
C
F
R
E
E
N
---------------
A
--
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
--
L
P
F
W
A
V
D
A
V
A
--
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
----------
I
P
A
L
L
-----
L
T
I
P
D
F
I
F
A
-----
N
-----
V
S
E
A
D
D
R
Y
I
C
D
R
F
Y
P
N
D
L
W
V
V
V
F
Q
F
--
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
--------
R
I
D
--------------------
E
--------
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
-----
S
L
N
A
A
K
S
---
E
-------
L
---------
D
-----
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
------------------
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
61
Fugue
69.61
13%
-114
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------------------
D
--
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
----------
I
V
S
G
L
T
S
-
F
L
P
I
Q
M
H
W
Y
R
A
------------
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
-----
C
D
F
F
T
--
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
-
L
--------
N
I
F
--------------------
E
--------
M
L
R
I
D
E
G
--
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
-----
G
H
L
L
T
K
S
PS
L
N
-------
A
---------
A
-----
K
S
-----------
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
------------------
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL-----
6
PsiBlast_PDB
64.45
24%
-149
- C1 -
4EIY
19
AA2AR_HUMAN (first)
A:
[37-199]
---------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
---
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
TP
M
L
G
W
N
N
C
-
G
Q
P
K
E
G
K
N
H
S
Q
-----
G
-----
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
--
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
A
D
L
E
D
N
W
E
T
-
L
--------
N
D
N
--------------------
L
--------
K
V
I
E
K
A
D
--
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
-----
D
A
Q
K
M
K
D
---
F
-------
R
---------
H
-----
G
F
-----------
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
------------------
A
Y
I
Q
K
Y
L
E
R
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.83
24%
-153
- C1 -
3VGA
1
AA2AR_HUMAN
A:
[14-174]
-----------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
---
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-
G
Q
-------
S
Q
-----
G
-----
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
--
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-
G
--------
E
R
A
--------------------
R
--------
S
T
L
Q
K
E
V
--
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
-----
L
P
L
H
I
I
N
---
C
-------
F
---------
T
-----
F
F
-----------
C
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
------------------
R
E
F
R
Q
T
F
R
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
63.16
25%
-156
- C1 -
3UZA
1
AA2AR_HUMAN
A:
[14-174]
-----------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
---
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-
G
Q
P
-------------
G
-----
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
--
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-
G
--------
E
R
A
--------------------
R
--------
S
T
L
Q
K
E
V
--
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
-----
L
P
L
H
I
I
N
---
C
-------
F
---------
T
-----
F
F
-----------
C
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
------------------
R
E
F
R
Q
T
F
R
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
62.64
24%
-156
- C1 -
3VG9
4
?
A:
[14-174]
-----------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
---
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
TP
M
L
G
W
N
N
C
-
G
Q
-------
S
Q
-----
G
-----
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
--
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-
G
--------
E
R
A
--------------------
R
--------
S
T
L
Q
K
E
V
--
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
-----
L
P
L
H
I
I
N
---
C
-------
F
---------
T
-----
F
F
-----------
C
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
------------------
R
E
F
R
Q
T
F
R
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
62.39
23%
-138
- C1 -
2YDO
3
?
A:
[14-174]
-----------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
---
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-
G
Q
P
K
E
G
K
A
H
S
Q
-----
G
-----
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
--
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
T
L
Q
K
-
E
--------
V
H
A
--------------------
A
--------
K
S
L
A
I
I
V
--
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
-----
F
F
C
P
D
C
S
---
H
-------
A
---------
P
-----
L
W
-----------
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
------------------
I
R
S
H
V
L
R
Q
Q
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
62.36
24%
-154
- C1 -
3QAK
1
ENLYS_BPT4
A:
[27-189]
---------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
---
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-
G
---------
Q
-----
G
-----
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
--
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
-
E
--------
G
L
R
--------------------
L
--------
K
I
Y
K
D
T
E
--
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
-----
N
A
A
K
S
E
L
---
D
-------
K
---------
A
-----
I
G
-----------
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
------------------
P
V
Y
D
S
L
D
A
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
62.24
25%
-156
- C1 -
3REY
1
AA2AR_HUMAN
A:
[14-174]
-----------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
---
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-
G
Q
P
-------------
G
-----
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
--
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-
G
--------
E
R
A
--------------------
R
--------
S
T
L
Q
K
E
V
--
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
-----
L
P
L
H
I
I
N
---
C
-------
F
---------
T
-----
F
F
-----------
C
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
------------------
R
E
F
R
Q
T
F
R
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
62.19
25%
-155
- C1 -
3RFM
1
AA2AR_HUMAN
A:
[14-174]
-----------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
---
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-
G
Q
P
-------------
G
-----
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
--
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-
G
--------
E
R
A
--------------------
R
--------
S
T
L
Q
K
E
V
--
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
-----
L
P
L
H
I
I
N
---
C
-------
F
---------
T
-----
F
F
-----------
C
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
------------------
R
E
F
R
Q
T
F
R
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
62.06
25%
-157
- C1 -
3PWH
1
?
A:
[14-174]
-----------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
---
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-
G
Q
P
-------------
G
-----
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
--
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-
G
--------
E
R
A
--------------------
R
--------
S
T
L
Q
K
E
V
--
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
-----
L
P
L
H
I
I
N
---
C
-------
F
---------
T
-----
F
F
-----------
C
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
------------------
R
E
F
R
Q
T
F
R
K
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
62.00
23%
-145
- C1 -
4UG2
3
?
A:
[14-174]
-----------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
---
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
TP
M
L
G
W
N
N
C
-
G
Q
P
K
E
G
K
A
H
S
Q
-----
G
-----
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
--
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
A
R
S
T
L
Q
K
E
V
-
H
--------
A
A
K
--------------------
S
--------
L
A
I
I
V
G
L
--
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-----
C
P
D
C
S
H
A
---
P
-------
L
---------
W
-----
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
------------------
S
H
V
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
61.55
23%
-144
- C1 -
4UHR
1
AA2AR_HUMAN
A:
[14-174]
-----------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
---
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
-
G
Q
P
K
E
G
K
A
--------
G
-----
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
--
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-
G
--------
E
R
A
--------------------
R
--------
S
T
L
Q
K
E
V
--
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
-----
L
P
L
H
I
I
N
---
C
-------
F
---------
T
-----
F
F
-----------
C
P
D
C
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
------------------
E
F
R
Q
T
F
R
K
I
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
61.46
20%
-152
- C1 -
3EML
8
ENLYS_BPT4
A:
[22-221]
----------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
----------
V
L
S
F
A
I
G
-
L
T
P
M
L
G
W
N
N
C
G
-----
Q
------------
S
Q
G
C
G
E
G
Q
---
V
A
C
L
F
E
D
VV
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
-
Q
--------
L
N
I
--------------------
F
--------
E
M
L
R
I
D
E
--
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
-----
I
G
H
L
L
T
K
---
S
-------
P
---------
S
-----
L
N
-----------
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
------------------
V
R
G
I
L
R
N
A
K
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------