@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10P1_HUMAN: (2016-01-11 )
MAGENHTTLPEFLLLGFSDLKALQGPLFWVVLLVYLVTLLGNSLIILLTQVSPALHSPMYFFLRQLSVVELFYTTDIVPRTLANLGSPHPQAISFQGCAAQMYVFIVLGISECCLLTAMAYDRYVAICQPLRYSTLLSPRACMAMVGTSWLTGIITATTHASLIFSLPFRSHPIIPHFLCDILPVLRLASAGKHRSEISVMTATIVFIMIPFSLIVTSYIRILGAILAMASTQSRRKVFSTCSSHLLVVSLFFGTASITYIRPQAGSSVTTDRVLSLFYTVITPMLNPIIYTLRNKDVRRALRHLVKRQRPSP
Atome Classification :
(20 SA)
........-----------------.10........20.....----------------...30........40........50........60........70--------......-..80-.........90........100.....-----...110.......120.......130.......140.......150.......160.......170....---...-180.........190.....--..200....------------...210.......220--...-------------------------....230.--------------------.--------.-----------....240.-------......---250-------.....---..260...------.--.---.--------.-------270-..--.-------......280.......290.......300------...-----...-------------------...310.---------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGENHTT-----------------
L
P
E
F
L
L
L
G
F
S
D
L
K
A
LQG
P
----------------
L
F
W
V
V
L
L
V
Y
L
V
T
L
LGN
S
L
I
I
L
L
TQV
S
P
A
LH
S
P
M
Y
F
F
L
R
Q
L
S
V
V
E
L
--------
F
YTTD
I
-
V
P
R
--
T
L
A
NLGSPHP
Q
A
I
S
FQG
C
A
A
-
Q
M
Y
V
F
I
-----
V
L
G
I
S
E
C
C
L
L
T
A
M
A
Y
D
R
Y
V
A
I
CQP
L
R
Y
S
TLLS
P
R
A
C
M
A
M
V
G
T
S
W
L
T
G
I
I
TATT
H
A
S
L
I
F
SLPFRSHP
I
I
P
---
H
F
L
-
C
--
D
I
L
P
V
L
R
L
A
SAGKHRS
E
--
I
S
V
M
T
A
T
I
V
------------
F
I
M
I
P
F
S
L
I
V
T
S
Y
I
R
I
--
L
G
A
-------------------------
I
L
A
M
AS
T
Q
--------------------
S
--------
R
-----------
R
K
V
F
S
T
C
S-------
S
H
L
L
V
V
---
S
L
F-------FGT
A
S
---
I
T
Y
I
RPQA------G--S---S--------V-------
T
---
T
D
--
R
-------
V
L
S
L
F
Y
T
V
I
T
P
M
L
N
P
I
I
Y
T
LR
N
K
D
V
R
R
--------
A
L
R
-----
H
L
V
-------------------
K
RQRPSP---------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.07
18%
-143
- C2 -
3PWH
1
?
A:
[12-305]
--------------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
--------
L
V
G
V
L
A
-
I
P
F
--
A
I
-
T
I
S
T
G
F
C
A
A
C
--
H
G
C
L
F
-
I
A
C
F
V
L
-----
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-------------
P
M
L
G
---
W
N
N
-
C
--
G
Q
P
--------
G
C
G
E
G
Q
--
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
YFNFFA
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
--------------------
I
--------
I
-----------
A
G
L
F
A
L
C
W
-------
L
P
L
H
I
I
---
N
C
F
----------------
T
F
F
C
P
D
C
------
S
--
H
---
A
--------
P
-------
L
---
W
L
--
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
87.51
19%
-153
- C2 -
2YDV
6
?
A:
[12-313]
--------------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
--------
L
V
G
V
L
A
-
I
P
F
--
A
I
A
-
I
S
T
G
F
C
A
A
C
--
H
G
C
L
F
-
I
A
C
F
V
L
-----
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-------------
P
M
L
G
---
W
N
N
-
C
--
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
--
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
YF
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
-
L
A
A
-------------------------
R
R
Q
L
K
Q
M
E
--------------------
S
--------
Q
S
T
L
--------
Q
K
E
V
H
A
A
K
-------
S
L
A
I
I
V
---
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
---
F
T
F
F
C
P
D
C
------
S
--
H
---
A
--------
P
-------
L
---
W
L
--
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S
H
V
L
-------------------
R
Q
Q
E
P
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
87.34
18%
-140
- C2 -
3UZC
1
AA2AR_HUMAN
A:
[12-305]
--------------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
--------
L
V
G
V
L
A
-
I
P
F
--
A
I
-
T
I
S
T
G
F
C
A
A
C
--
H
G
C
L
F
-
I
A
C
F
V
L
-----
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-------------
P
M
L
G
---
W
N
N
-
C
--
G
Q
P
--------
G
C
G
E
G
Q
--
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
YFNFFA
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
--------------------
I
--------
I
-----------
A
G
L
F
A
L
C
W
-------
L
P
L
H
I
I
---
N
C
F
----------------
T
F
F
C
P
D
C
------
S
--
H
---
A
--------
P
-------
L
---
W
L
--
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
87.27
18%
-141
- C2 -
3RFM
1
AA2AR_HUMAN
A:
[12-305]
--------------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
--------
L
V
G
V
L
A
-
I
P
F
--
A
I
-
T
I
S
T
G
F
C
A
A
C
--
H
G
C
L
F
-
I
A
C
F
V
L
-----
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-------------
P
M
L
G
---
W
N
N
-
C
--
G
Q
P
--------
G
C
G
E
G
Q
--
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
YFNFFA
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
--------------------
I
--------
I
-----------
A
G
L
F
A
L
C
W
-------
L
P
L
H
I
I
---
N
C
F
----------------
T
F
F
C
P
D
C
------
S
--
H
---
A
--------
P
-------
L
---
W
L
--
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
87.24
19%
-150
- C2 -
2YDO
3
?
A:
[12-313]
--------------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
--------
L
V
G
V
L
A
-
I
P
F
--
A
I
A
-
I
S
T
G
F
C
A
A
C
--
H
G
C
L
F
-
I
A
C
F
V
L
-----
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-------------
P
M
L
G
---
W
N
N
-
C
--
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
--
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
YF
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
-
L
A
A
-------------------------
R
R
Q
L
K
Q
M
E
--------------------
S
---------T
L
---------
Q
K
E
V
H
A
A
K
-------
S
L
A
I
I
V
---
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
---
F
T
F
F
C
P
D
C
------
S
--
H
---
A
--------
P
-------
L
---
W
L
--
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S
H
V
L
-------------------
R
Q
Q
E
P
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
87.01
18%
-139
- C2 -
3REY
1
AA2AR_HUMAN
A:
[12-305]
--------------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
--------
L
V
G
V
L
A
-
I
P
F
--
A
I
-
T
I
S
T
G
F
C
A
A
C
--
H
G
C
L
F
-
I
A
C
F
V
L
-----
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-------------
P
M
L
G
---
W
N
N
-
C
--
G
Q
P
--------
G
C
G
E
G
Q
--
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
YFNFFA
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
--------------------
I
--------
I
-----------
A
G
L
F
A
L
C
W
-------
L
P
L
H
I
I
---
N
C
F
----------------
T
F
F
C
P
D
C
------
S
--
H
---
A
--------
P
-------
L
---
W
L
--
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.82
18%
-140
- C2 -
3UZA
1
AA2AR_HUMAN
A:
[12-305]
--------------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
--------
L
V
G
V
L
A
-
I
P
F
--
A
I
-
T
I
S
T
G
F
C
A
A
C
--
H
G
C
L
F
-
I
A
C
F
V
L
-----
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-------------
P
M
L
G
---
W
N
N
-
C
--
G
Q
P
--------
G
C
G
E
G
Q
--
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
YFNFFA
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
--
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
--------------------
I
--------
I
-----------
A
G
L
F
A
L
C
W
-------
L
P
L
H
I
I
---
N
C
F
----------------
T
F
F
C
P
D
C
------
S
--
H
---
A
--------
P
-------
L
---
W
L
--
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
86.65
18%
-126
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---
M
N
G
T
E
-----------------
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
FEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
--------
F
M
V
F
G
G
-
F
T
T
--
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
-
E
G
F
F
A
T
-----
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-------
V
G
W
S
R
Y
I
P
---
E
G
M
Q
C
--
S
C
G
I
D
Y
-
Y
T
P
H
E
E
T
N
N
E
--
S
F
V
I
Y
M
F
V
V
------------
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
--
V
F
T
-------------------------
V
K
E
A
A
A
S
A
--------------------
T
--------
T
-----------
Q
K
A
E
K
E
V
T
-------
R
M
V
I
I
M
---
V
I
A
-------
F
L
I
C
W
---
L
P
Y
A
G
V
A
F
------
Y
--
I
---
F
--------
T
-------
H
---
Q
G
--
S
DFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
--------
C
M
V
-----
T
T
L
-------------------
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A-------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
85.71
20%
-151
- C2 -
3VGA
1
AA2AR_HUMAN
A:
[12-308]
--------------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
--------------------
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-------------
P
M
L
G
---
W
N
N
-
C
--
G
Q
-------
S
Q
G
C
G
E
G
Q
--
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
YFNFFA
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
-
L
A
A
-------------------------
R
R
Q
L
K
Q
M
E
--------------------
S
--------
Q
PLPGERA
R
S
T
L
Q
K
E
V
H
A
A
K
-------
S
L
A
I
I
V
---
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
---
F
T
F
F
C
P
D
C
------
S
--
H
---
A
--------
P
-------
L
---
W
L
--
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S
H
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
85.20
16%
-141
- C2 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
------------------------------------------
L
----------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
--------
S
M
A
A
F
N
-
T
V
V
--
N
F
T
Y
A
V
H
N
E
W
Y
-
Y
G
L
F
Y
C
K
F
-
H
N
F
F
P
I
-----
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
-
T
T
E
---
T
-
M
P
S
---
R
V
V
-
C
--
M
I
E
W
P
E
H
---
P
N
K
I
Y
E
K
--
V
Y
H
I
C
V
T
V
L
------------
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
--
G
I
T
-------------------------
L
W
A
S
E
I
P
G
DSSDRYH
E
Q
V
S
---------
A
--------
K
-----------
R
K
V
V
K
M
M
I
-------
V
V
V
C
T
F
---
A
I
C
-------
W
L
P
F
H
---
I
F
F
L
L
P
Y
I
------
N
PD
L
YL-
K
--------
K
-------
F
---
I
Q
Q
V
Y
-------
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
--------
G
F
K
-----
H
A
F
-------------------
R
C
C
P
F
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
85.07
19%
-154
- C2 -
4UG2
3
?
A:
[12-309]
--------------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
--------
L
V
G
V
L
A
-
I
P
F
--
A
I
A
-
I
S
T
G
F
C
A
A
C
--
H
G
C
L
F
-
I
A
C
F
V
L
-----
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-------------
P
M
L
G
---
W
N
N
-
C
--
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
--
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
YF
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
-
L
A
A
-------------------------
R
R
Q
L
----------------------------------A
R
S
T
L
------
Q
K
E
V
H
A
A
K
-------
S
L
A
I
I
V
---
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
---
F
T
F
F
C
P
D
C
------
S
--
H
---
A
--------
P
-------
L
---
W
L
--
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S
H
V
L
-------------------
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
84.58
15%
-134
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-334]
---------------------------------------
V
Y
Y
S
----------------
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
--------
T
F
S
L
V
N
G
F
P
L
--
M
T
I
S
C
F
L
K
K
W
I
-
F
G
F
A
A
C
K
V
-
Y
G
F
I
G
G
-----
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
---
L
-
E
G
V
---
L
C
N
-
C
--
S
F
D
Y
I
S
-----
R
D
S
T
T
R
--
S
N
I
L
C
M
F
I
L
------------
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
--
V
M
S
-------------------------
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
--------
E
-----------
M
R
L
A
K
I
S
I
-------
V
I
V
S
Q
F
---
L
L
S
-------
W
S
P
Y
A
---
V
V
A
L
L
A
Q
F
------
G
--
P
LEW
V
--------
T
-------
P
---
Y
A
--
A
-------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
--------
A
I
S
-----
Q
T
F
-------------------
P
W
V
L
T
C
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
84.14
19%
-150
- C2 -
4UHR
1
AA2AR_HUMAN
A:
[12-313]
--------------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
--------
L
V
G
V
L
A
-
I
P
F
--
A
I
A
-
I
S
T
G
F
C
A
A
C
--
H
G
C
L
F
-
I
A
C
F
V
L
-----
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-------------
P
M
L
G
---
W
N
N
-
C
--
G
Q
P
K
E
G
K
A
---
G
C
G
E
G
Q
--
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
YFNFFA
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
-
L
A
A
-------------------------
R
R
Q
L
K
Q
M
E
--------------------
S
--------
Q
PLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
-------
S
L
A
I
I
V
---
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
---
F
T
F
F
C
P
D
C
---------
H
---
A
--------
P
-------
L
---
W
L
--
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S
H
V
L
-------------------
R
Q
Q
E
P
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
83.91
20%
-148
- C2 -
3VG9
8
?
A:
[12-309]
--------------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
--------------------
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
CFV
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-------------
P
M
L
G
---
W
N
N
-
C
--
G
Q
-------
S
Q
G
C
G
E
G
Q
--
V
A
C
L
F
E
D
V
V
PMNYMVYFNFFA
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
-
L
A
A
-------------------------
R
R
Q
L
K
Q
M
E
--------------------
S
--------
Q
PLPGERA
R
S
T
L
Q
K
E
V
H
A
A
K
-------
S
L
A
I
I
V
---
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
---
F
T
F
F
C
P
D
C
------
S
--
H
---
A
--------
P
-------
L
---
W
L
--
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
--------
T
F
R
K
I
I
R
S
H
V
L
-------------------
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
81.58
19%
-112
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
FYVPFSNKTGVVRSPFE
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
----------------
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
--------
F
M
V
F
G
G
-
F
T
T
--
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
-
E
G
F
F
A
T
-----
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
-
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-------
V
G
W
S
R
Y
I
P
E
GM
Q
C
S
-
C
G
I
D
Y
Y
T
-----
P
H
E
E
T
N
N
E
--
S
F
V
I
Y
M
F
V
V
------------
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
--
V
F
T
-------------------------
V
K
E
A
A
A
Q
Q
QESA----------------
T
--------
T
-----------
Q
K
A
E
K
E
V
T
-------
R
M
V
I
I
M
---
V
I
A
-------
F
L
I
C
W
---
L
P
Y
A
G
V
A
F
------
Y
--
I
---
F
--------
T
H
QGSDFG
P
---
I
F
--
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
--------
C
M
V
-----
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A--------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
77.59
17%
-129
- C2 -
1U19
14
OPSD_BOVIN
A:
[42-327]
------------------------------------------
M
----------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
--------
F
M
V
F
G
G
-
F
T
T
--
T
L
Y
T
S
L
H
G
Y
F
V
-
F
G
P
T
G
C
N
L
-
E
G
F
F
A
T
-----
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
---
P
-
E
G
M
---
Q
C
S
-
C
--
G
I
D
Y
Y
T
P
---
H
E
E
T
N
N
E
--
S
F
V
I
Y
M
F
V
V
------------
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
--
V
F
T
-------------------------
V
K
E
A
A
A
Q
Q
--------------------
Q
ESA
T
T
Q
K
A
E
-----------
K
E
V
T
R
M
V
I
-------
I
M
V
I
A
F
---
L
I
C
-------
W
L
P
Y
A
---
G
V
A
F
Y
I
F
T
H
Q----
G
S-
D
---
F
--------
G
-------
P
---
I
F
--
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
--------
C
M
V
-----
T
T
L
-------------------
C
C
G
K
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
72.90
15%
-114
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
------------------------------------
D
E
V
W
V
V
G
----------------
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
--------
V
M
G
L
A
V
-
V
P
F
--
G
A
A
H
I
L
M
-
K
M
W
T
F
G
N
F
W
C
E
F
-
W
T
S
I
D
V
-----
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
----
H
W
Y
R
A
T
H
Q
E
---
A
I
N
-
C
--
Y
A
E
E
----
T
C
C
D
F
F
T
N
Q
--
A
Y
A
I
A
S
S
I
V
------------
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
--
F
Q
E
-------------------------
A
K
R
Q
--
L
N
--------------------
I
--------
F
-----------
E
M
L
R
I
D
E
G
-------
L
R
L
K
I
Y
---
K
D
T
-------
E
G
Y
Y
T
---
I
G
I
G
H
L
L
T
------
K
--
S
---
P
--------
S
-------
L
---
N
A
--
A
-------
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
--------
D
V
D
-----
A
A
V
-------------------
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
3
PsiBlast_PDB
71.43
22%
-109
- C2 -
4U14
1
ENLYS_BPT4
A:
[24-290]
--------------------------------------------------------------------
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
M
N
L
F
T
T
Y
I
-
I
M
N
RW
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
-
S
V
M
N
L
L
-----
V
I
-----------
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
--
P
A
I
L
F
W
Q
Y
F
V
G
K
R
T
V
P
---
P
G
E
-
C
--
F
I
----------
Q
F
L
S
E
P
T
I
T
F
G
T
A
I
A
A
------------
F
Y
M
-
P
V
T
I
M
T
I
L
Y
W
R
I
--
Y
K
E
-------------------------
T
E
K
M
N
C
F
E
--------------------
M
L
R
I
D
EGL-
R
-----------
L
K
I
Y
K
D
C
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
---
S
P
S
-------
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
------
N
--
G
---
V
--------
I
-------
T
---
K
D
--
E
-------
A
E
K
L
F
----------------
N
Q
D
V
D
A
--------
A
V
R
-----
G
I
L
-------------------
R
N
A
K
L
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
71.32
16%
-124
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
----------------------------------------
K
Y
V
----------------
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
--------
L
F
A
L
-
T
-
L
P
I
--
W
A
A
S
K
V
-
N
G
W
I
-
F
G
T
F
L
C
K
V
-
V
S
L
L
K
E
-----
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
H
---
P
-
N
N
S
---
S
P
V
-
C
--
Y
E
V
L
G
N
---
D
-
T
A
K
W
R
M
--
V
L
R
I
L
P
H
T
F
------------
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
--
L
R
T
-------------------------
L
F
K
A
H
M
-
G
--------------------
Q
--------
K
-----------
H
R
A
M
R
V
I
F
-------
A
V
V
L
I
F
---
L
L
C
-------
W
L
P
Y
N
---
L
V
L
L
A
D
T
L
M
RTQVI
Q
--
E
---
S
C
E
R
-----
R
-------
N
N
I
G
R
A
--
L
-------
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
--------
G
F
L
-----
K
I
L
-------------------
A
M
H
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
68.98
16%
-120
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
--------------------------
P
C
F
R
E
---
E
N
A
N
F
N
K
I
F
----------------
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
--------
L
F
V
I
-
T
-
L
P
F
--
W
A
V
D
A
V
A
N
W
Y
F
--
G
N
F
L
C
K
A
-
V
H
V
I
Y
T
-----
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
-----
A
N
V
S
E
A
D
D
---
R
Y
I
-
C
--
D
R
F
Y
P
N
D
L
W
V
V
V
F
Q
F
Q
H
--
I
M
V
G
L
I
L
P
G
------------
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
SG
S
N
I
-------------------------
F
E
M
L
R
I
D
E
--------------------
G
--------
L
-----------
R
L
K
I
Y
K
D
T
-------
E
G
Y
Y
T
I
GIG
H
L
L
-------
T
K
S
P
S
---
L
N
A
A
K
S
E
L
------
D
--
K
---
A
IGRNTNGV
I
-------
T
---
K
D
--
E
-------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
-----
N
M
V
-------------------
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ-------