@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O11H1_HUMAN: (2016-01-11 )
MCPLTLQVTGLMNVSEPNSSFAFVNEFILQGFSCEWTIQIFLFSLFTTTYALTITGNGAIAFVLWCDRRLHTPMYMFLGNFSFLEIWYVSSTVPKMLVNFLSEKKNISFAGCFLQFYFFFSLGTSECLLLTVMAFDQYLAICRPLLYPNIMTGHLYAKLVILCWVCGFLWFLIPIVLISQMPFCGPNIIDHVVCDPGPRFALDCVSAPRIQLFCYTLSSLVIFGNFLFIIGSYTLVLKAMLGMPSSTGRHKAFSTCGSHLAVVSLCYSSLMVMYVSPGLGHSTGMQKIETLFYAMVTPLFNPLIYSLQNKEIKAALRKVLGSSNII
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80.......-.90.-.......100.......110------.........120.......130.......140.......150.......160.......170.......180.........190.......200--....--...210.----......-----220.......230.......240...------------------------------------------------------------------------------------------------------------------------------------------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------..-----.250.......----260-------..----......270.----....-----------..280---.----.......290.......300.......310.......320....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MC
P
L
T
L
Q
V
T
G
L
M
NVSEPNS
S
F
A
F
V
N
E
F
I
LQGFS
C
E
W
T
I
Q
I
F
L
F
S
L
FT
T
T
Y
A
L
T
I
TGNG
A
I
A
F
V
L
W
CDRRLHT
P
M
Y
M
F
LGN
F
S
F
L
E
I
W
Y-VSST-
V
P
K
M
L
V
N
F
L
S
EKKNI
S
F
A
--------
G
C
F
L
Q
F
Y
F
F
FSLGTS
E
C
L
L
L
T
V
M
A
F
D
Q
Y
L
A
I
C
R
P
L
LYPNI
M
T
G
H
L
Y
A
K
L
V
I
L
C
W
V
C
G
F
L
W
F
L
I
P
I
V
L
ISQ--MPFCG
P
N
I
I
D
HVVCDPGP
R
F
A
L
--DCVS--AP
R
I
Q
L
F
----
C
Y
T
L
S
S
-----
L
V
I
F
G
N
F
L
F
II
G
S
Y
T
L
V
L
K
A
M
LGMPS------------------------------------------------------------------------------------------------------------------------------------------------------------------S-----------------------------------------------------------------------------------------------------------------------------------------------------------------TG-----R
H
K
A
F
S
T
C
G
S
H
----
L
A
--------
V
V
----
S
L
C
Y
S
S
L
M
V
M
----
Y
VSP-----------GLGH----
S
----
T
G
M
Q
K
I
E
T
L
F
Y
A
M
V
T
P
L
F
N
P
L
I
Y
S
LQN
K
E
I
K
A
A
L
R
K
V
LGSSNII
4
PsiBlast_PDB
88.60
23%
-145
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[19-305]
---------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
-
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
--------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
CG
Q
P
----------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
NFFA
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
-----
R
A
R
S
T
L
Q
K
E
V
H
----
A
A
K
S
A
A
I
I
A
G
L
F
----
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-----------
D
C
S
H
----
A
----
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----
2
PsiBlast_PDB
87.83
23%
-143
- C3 -
3REY
1
AA2AR_HUMAN
A:
[19-305]
---------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
-
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
--------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
CG
Q
P
----------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
NFFA
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
-----
R
A
R
S
T
L
Q
K
E
V
H
----
A
A
K
S
A
A
I
I
A
G
L
F
----
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-----------
D
C
S
H
----
A
----
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----
3
PsiBlast_PDB
87.50
23%
-146
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[19-305]
---------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
-
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
--------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
CG
Q
P
----------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
NFFA
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
-----
R
A
R
S
T
L
Q
K
E
V
H
----
A
A
K
S
A
A
I
I
A
G
L
F
----
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-----------
D
C
S
H
----
A
----
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----
1
PsiBlast_PDB
87.49
23%
-144
- C3 -
3PWH
1
?
A:
[19-305]
---------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
-
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
--------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
CG
Q
P
----------
G
C
G
E
G
Q
V
A
C
L
FE
D
V
V
P
--
M
N
Y
M
V
Y
F
NFFA
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
-----
R
A
R
S
T
L
Q
K
E
V
H
----
A
A
K
S
A
A
I
I
A
G
L
F
----
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-----------
D
C
S
H
----
A
----
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----
5
PsiBlast_PDB
86.83
23%
-144
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[19-305]
---------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
-
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
--------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
CG
Q
P
----------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
NFFA
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
-----
R
A
R
S
T
L
Q
K
E
V
H
----
A
A
K
S
A
A
I
I
A
G
L
F
----
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-----------
D
C
S
H
----
A
----
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----
11
PsiBlast_PDB
86.60
22%
-149
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[19-305]
---------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
-
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
--------
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
--
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
NFFA
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
-----
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
--------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-----------
D
C
S
H
----
A
----
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
-
33
HHSearch
85.47
18%
-146
- C3 -
3EML
13
ENLYS_BPT4
A:
[22-469]
---------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
-
G
V
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
C
A
A
C
H
--------
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
--
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
-----
A
C
L
F
ED
V
V
P
M
N
Y
M
----
V
Y
F
N
F
F
-----
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
-----
E
V
H
A
A
K
S
L
A
I
I
----
V
G
--------
L
F
----
A
L
C
W
L
P
L
H
I
I
----
N
C
F
T
-----------
F
F
C
P
DCSH
A
----
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
10
PsiBlast_PDB
83.03
22%
-143
- C3 -
3VG9
8
?
A:
[19-305]
---------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
-
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
--------
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
--
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
NFFA
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
-----
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
--------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-----------
D
C
S
H
----
A
----
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
26
HHSearch
82.50
17%
-140
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[39-477]
-------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
-
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
--------
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
--
R
A
T
----
H
Q
E
A
I
N
C
Y
A
E
E
------
T
C
C
D
--
F
F
T
N
Q
A
Y
----
A
I
A
S
S
I
-----
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC
L
K
-----
E
H
K
A
L
K
T
L
G
I
I
----
M
G
--------
T
F
----
T
L
C
W
L
P
F
F
I
V
----
N
I
V
H
-----------
V
I
Q
D
NL--
I
----
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----
30
HHSearch
81.71
18%
-132
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
-----------------------------------
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
-
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
-
T
T
Y
K
L
T
P
A
--------
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
--------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
W
N
C
--
I
-------
S
A
L
S
S
C
S
T
V
L
P
L
------------
Y
H
K
-
H
----
Y
I
L
F
C
T
-----
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
-----
N
V
A
L
L
K
T
V
I
I
V
----
L
S
--------
V
F
----
I
A
C
W
A
P
L
F
I
L
----
L
L
L
D
-----------
V
G
C
K
----
V
KTC
D
I
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
--
27
HHSearch
81.03
17%
-133
* C3 *
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
----------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
-
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
S
K
W
S
L
G
R
P
--------
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
-
W
N
H
----------
R
R
E
D
K
C
E
T
D
F
Y
--------
D
-----
V
T
W
F
----
K
V
M
T
A
I
-----
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
-----
E
R
K
A
A
K
Q
L
G
F
I
----
M
A
--------
A
F
----
I
L
C
W
I
P
Y
F
I
F
----
F
M
V
I
-----------
A
F
C
K
----
N
CC--
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
----
9
PsiBlast_PDB
80.73
22%
-143
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[19-305]
---------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-----------
V
S
A
A
-
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
I
S
TGFCAA
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
--
C
G
Q
P
K
E
G
K
A
---
G
C
G
E
G
Q
V
A
C
L
FE
D
V
V
P
--
M
N
Y
M
V
Y
F
NFFA
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
-----
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
--------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-----------
D
C
-
H
----
A
----
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
7
PsiBlast_PDB
79.30
22%
-143
- C3 -
2YDV
6
?
A:
[19-305]
---------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-----------
V
S
A
A
-
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
GFCAA
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
--
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
FE
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
--------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-----------
D
C
S
H
----
A
----
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
31
HHSearch
78.08
18%
-138
- C3 -
2Z73
5
OPSD_TODPA
A:
[31-332]
-----------------------------------
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
-
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
--------
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
--
Y
T
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
-------
R
--
D
S
T
T
R
S
N
----
I
L
C
M
F
I
-----
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
-----
E
M
R
L
A
K
I
S
I
V
I
----
V
S
--------
Q
F
----
L
L
S
W
S
P
Y
A
V
V
----
A
L
L
A
-----------
Q
F
G
P
LEW-
V
----
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
6
PsiBlast_PDB
77.85
22%
-142
- C3 -
2YDO
3
?
A:
[19-305]
---------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-----------
V
S
A
A
-
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
GFCAA
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
--
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
FE
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
--------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-----------
D
C
S
H
----
A
----
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
25
HHSearch
77.57
15%
-142
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
---------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
-
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
I
G
Y
W
P
L
G
P
V
--------
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
--
I
V
G
V
R
--
T
V
E
D
G
E
C
Y
I
Q
F
F
-------------
S
N
A
A
V
----
T
F
G
T
A
I
-----
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
-----
E
K
K
V
T
R
T
I
L
A
I
----
L
L
--------
A
F
----
I
I
T
W
A
P
Y
N
V
M
----
V
L
I
N
-----------
T
F
C
A
PC--
I
----
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----
8
PsiBlast_PDB
76.97
22%
-147
- C3 -
4UG2
3
?
A:
[19-305]
---------------------------------------------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-----------
V
S
A
A
-
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
--
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
FE
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
-----
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
--------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-----------
D
C
S
H
----
A
----
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
12
PsiBlast_PDB
74.99
20%
-112
- C3 -
2Z73
5
OPSD_TODPA
A:
[63-328]
-------------------------------------------------------------------
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
-
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
--------
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
--------
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
-
I
--
S
R
D
S
--
T
T
R
S
N
I
L
----
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
AKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
----
L
A
--------
K
I
----
S
I
V
I
V
S
Q
F
L
L
----
S
W
S
P
Y
A
V
V
A
L
L
A
Q
FG
P
L
E
W
----
V
----
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
16
PsiBlast_PDB
74.60
20%
-110
- C3 -
4WW3
5
OPSD_TODPA
A:
[55-320]
-------------------------------------------------------------------
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
-
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
--------
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
--------
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
-
I
--
S
R
D
S
--
T
T
R
S
N
I
L
----
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
AKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
----
L
A
--------
K
I
----
S
I
V
I
V
S
Q
F
L
L
----
S
W
S
P
Y
A
V
V
A
L
L
A
Q
FG
P
L
E
W
----
V
----
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
14
PsiBlast_PDB
74.54
20%
-110
- C3 -
3AYN
3
OPSD_TODPA
A:
[63-328]
-------------------------------------------------------------------
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
-
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
--------
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
--------
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
-
I
--
S
R
D
S
--
T
T
R
S
N
I
L
----
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
AKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
----
L
A
--------
K
I
----
S
I
V
I
V
S
Q
F
L
L
----
S
W
S
P
Y
A
V
V
A
L
L
A
Q
FG
P
L
E
W
----
V
----
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C