@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2M5_HUMAN: (2016-01-13 )
MAWENQTFNSDFILLGIFNHSPTHTFLFFLVLAIFSVAFMGNSVMVLLIYLDTQLHTPMYFLLSQLFLMDLMLICSTVPKMAFNYLSGSKSISMAGCATQIFFYVSLLGSECFLLAVMSYDRYIAICHPLRYTNLMRPKICGLMTAFSWILGSMDAIIDAVATFSFSYCGSREIAHFFCDFPSLLILSCNDTSIFEKVLFICCIVMIVFPVAIIIASYARVILAVIHMGSGEGRRKAFTTCSSHLMVVGMYYGAGLFMYIRPTSDRSPMQDKLVSVFYTILTPMLNPLIYSLRNKEVTRALRKVLGKGKCGE
Atome Classification :
(20 SA)
.........10.....----------------...20........30........40........50........60........70......-..80........90........100.......110..--.....120.......130.......140..-.....150--------.........160.......170.......180.......-------190.......200.......210.......220..----.....230--.--------------------....----....240..-------.....250------------......-------...260...---....270.......280--.......290.......300...--....310-----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAWENQTFNS
D
F
I
L
L
G
----------------
I
FNHSP
T
H
T
F
L
F
F
L
V
L
A
I
F
S
V
A
FMGN
S
V
M
V
L
L
I
Y
LDTQLH
T
P
M
Y
F
L
L
S
Q
L
F
L
M
D
L
M
L
I
C
ST-
V
P
K
M
A
F
N
YLSGSKSIS
M
A
G
C
A
T
Q
I
F
F
Y
V
S
L
LGS
E
C
F
L
--
L
A
V
MSYD
R
Y
I
A
I
CH
P
L
R
Y
TNLM
R
P
K
I
C
G
L
M
-
T
A
F
S
W
I
----------LG
S
M
D
A
I
I
D
A
V
A
T
F
S
F
SYCGS
R
E
I
A
H
F
F
CDFPS
L
L
I
L
SC-------N
D
T
S
I
F
E
K
V
L
F
I
C
C
I
V
M
I
V
F
P
V
A
I
I
I
A
S
Y
A
R
V
I
L
A
----
V
I
HMGS----G--------------------EGR
R
----
K
A
F
T
T
CSS
H
-------
L
M
V
V
G
M
--------------YYG
A
G
L
-------
F
M
Y
I
RPTSD---RS
P
M
Q
D
K
L
V
S
V
F
Y
T
I
L
T
--
P
M
L
N
P
L
I
Y
S
LR
N
K
E
V
T
R
A
L
R
K
V
L--GKGKCGE-----------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
91.56
22%
-162
- C2 -
3PWH
1
?
A:
[14-303]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
-
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PM
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
-----
V
V
P
M
-------
N
Y
M
V
Y
F
N
--
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
----
L
K
Q
M
E
S
QPLP
G
--------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
-------
A
I
I
A
G
L
--------------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
---
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
--
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
91.32
22%
-160
- C2 -
3RFM
1
AA2AR_HUMAN
A:
[14-303]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
-
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PM
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
-----
V
V
P
M
-------
N
Y
M
V
Y
F
N
--
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
----
L
K
Q
M
E
S
QPLP
G
--------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
-------
A
I
I
A
G
L
--------------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
---
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
--
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
90.88
22%
-161
- C2 -
3UZA
1
AA2AR_HUMAN
A:
[14-303]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
-
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PM
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
-----
V
V
P
M
-------
N
Y
M
V
Y
F
N
--
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
----
L
K
Q
M
E
S
QPLP
G
--------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
-------
A
I
I
A
G
L
--------------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
---
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
--
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
90.85
22%
-160
- C2 -
3REY
1
AA2AR_HUMAN
A:
[14-303]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
-
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PM
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
-----
V
V
P
M
-------
N
Y
M
V
Y
F
N
--
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
----
L
K
Q
M
E
S
QPLP
G
--------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
-------
A
I
I
A
G
L
--------------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
---
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
--
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
90.19
23%
-163
- C2 -
3VGA
1
AA2AR_HUMAN
A:
[14-303]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
-
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PM
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
-----
V
V
P
M
-------
N
Y
M
V
Y
F
N
--
F
F
A
C
V
L
V
----
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
PLP
G
--------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
-------
A
I
I
V
G
L
--------------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
---
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
--
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
89.77
22%
-161
- C2 -
3UZC
1
AA2AR_HUMAN
A:
[14-303]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
-
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PM
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
-----
V
V
P
M
-------
N
Y
M
V
Y
F
N
--
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
----
L
K
Q
M
E
S
QPLP
G
--------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
-------
A
I
I
A
G
L
--------------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
---
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
--
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
88.36
18%
-134
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---
M
N
G
T
E
G
P
N
F
Y
V
P
F
SNKTGVVRSPFEAPQY
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
-
V
A
F
T
W
V
----------
M
A
L
A
C
A
---
A
P
P
L
V
G
W
S
R
-----------
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
A
----
S
--------------------
A
T
T
Q
----
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
--------------
P
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
S
---
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
--
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
87.96
23%
-159
- C2 -
3VG9
8
?
A:
[14-303]
-----------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
-
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
-
I
A
I
C
W
V
L
S
F
A
I
G
L
TPM
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
-----
V
V
P
M
-------
N
Y
M
V
Y
F
N
--
F
F
A
C
V
L
V
----
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
PLP
G
--------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
-------
A
I
I
V
G
L
--------------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
---
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
--
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
84.91
21%
-156
- C2 -
3DQB
6
GNAT1_BOVIN (first)
A:
[43-326]
-----------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
----
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
----------
M
--------
A
L
A
------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
A
----
Q
--------------------
Q
--
Q
----
E
S
A
T
T
Q
K
A
E
-------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
I
F
T
H
Q
G
S
D
---
F
G
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
--
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
82.47
21%
-158
- C2 -
3CAP
5
OPSD_BOVIN
A:
[43-326]
-----------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
----
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
----------
M
--------
A
L
A
------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
A
----
Q
--------------------
Q
--
Q
----
E
S
A
T
T
Q
K
A
E
-------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
I
F
T
H
Q
G
S
D
---
F
G
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
--
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
81.92
21%
-139
- C2 -
3OAX
17
OPSD_BOVIN
A:
[46-331]
-----------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
----
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
----------
M
--------
A
L
A
------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
A
----
Q
--------------------
Q
--
Q
----
E
S
A
T
T
Q
K
A
E
-------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
I
F
T
H
Q
G
S
D
---
F
G
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
--
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
81.91
21%
-152
- C2 -
3PXO
5
OPSD_BOVIN
A:
[43-326]
-----------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
----
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
----------
M
--------
A
L
A
------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
A
----
Q
--------------------
Q
--
Q
----
E
S
A
T
T
Q
K
A
E
-------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
I
F
T
H
Q
G
S
D
---
F
G
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
--
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
81.87
21%
-154
- C2 -
3PQR
10
OPSD_BOVIN
A:
[43-326]
-----------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
----
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
----------
M
--------
A
L
A
------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
A
----
Q
--------------------
Q
--
Q
----
E
S
A
T
T
Q
K
A
E
-------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
I
F
T
H
Q
G
S
D
---
F
G
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
--
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
81.70
21%
-142
- C2 -
1HZX
14
OPSD_BOVIN
A:
[46-331]
-----------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
----
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
----------
M
--------
A
L
A
------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
A
-----------------------------------
A
T
T
Q
K
A
E
-------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
I
F
T
H
Q
G
S
D
---
F
G
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
--
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
81.51
21%
-153
- C2 -
4J4Q
9
GNAT1_BOVIN (first)
A:
[43-326]
-----------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
----
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
----------
M
--------
A
L
A
------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
A
----
Q
--------------------
Q
--
Q
----
E
S
A
T
T
Q
K
A
E
-------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
I
F
T
H
Q
G
S
D
---
F
G
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
--
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
81.05
21%
-154
- C2 -
4PXF
8
OPSD_BOVIN
A:
[43-326]
-----------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
----
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
----------
M
--------
A
L
A
------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
GIDYYTP
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
A
----
Q
--------------------
Q
--
Q
----
E
S
A
T
T
Q
K
A
E
-------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
I
F
T
H
Q
G
S
D
---
F
G
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
--
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
80.96
16%
-149
- C2 -
2Z73
5
OPSD_TODPA
A:
[34-333]
---------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
--
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
-
I
I
F
V
W
L
----------
W
S
V
L
W
A
I
G
P
I
F
G
W
-
G
--
A
Y
T
-
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
------------
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
----
V
S
N
H
E
K
----
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
----
R
L
A
K
I
S
I
V
I
-------
V
S
Q
F
L
L
--------------
S
W
S
P
Y
A
-------
V
V
A
L
L
A
Q
F
G
PLE
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
--
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
--
P
W
V
L
T
C
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
79.48
21%
-147
- C2 -
2I36
2
OPSD_BOVIN
A:
[43-326]
-----------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
----
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
----------
M
--------
A
L
A
------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
YYTP
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----
V
K
E
A
A
A
----
Q
--------------------
Q
--
Q
----
E
S
A
T
T
Q
K
A
E
-------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
ICWLP
Y
A
G
V
A
F
-------
Y
I
F
T
H
Q
G
S
D
---
F
G
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
--
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
78.51
21%
-150
- C2 -
2I37
1
OPSD_BOVIN
A:
[43-329]
-----------------------------------------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
----
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
----------
M
--------
A
L
A
------
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
-------------------------------------------
E
S
A
T
T
Q
K
A
E
-------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
I
F
T
H
Q
G
S
D
---
F
G
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
--
A
V
Y
N
P
V
I
Y
I
M
M
N
---
R
N
C
M
V
T
T
L
CC
G
K
N
P
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
78.27
16%
-123
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-----------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
-
I
L
M
V
W
I
----------
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
--
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
-----
C
-------
D
F
F
T
-
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
----
A
K
R
Q
L
N
----
I
--------------------
F
E
M
L
----
R
I
D
E
G
L
R
L
K
-------
I
Y
K
D
T
E
--------------
G
Y
Y
T
I
G
-------
I
G
H
L
L
T
K
S
P
---
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
NG
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
--
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL