@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR5M3_HUMAN: (2016-01-13 )
MLNFTDVTEFILLGLTSRREWQVLFFIIFLVVYIITMVGNIGMMVLIKVSPQLNNPMYFFLSHLSFVDVWFSSNVTPKMLENLLSDKKTITYAGCLVQCFFFIALVHVEIFILAAMAFDRYMAIGNPLLYGSKMSRVVCIRLITFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKMACAGTFVKEYTMIILAGINFTYSLTVIIISYLFILIAILRMRSAEGRQKAFSTCGSHLTAVIIFYGTLIFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPMIYSLRNKDVKKAMMKVISRSC
Atome Classification :
(20 SA)
.........10.-----------------..----------------.....20...---.....----30-..-------.--.....40.....--...50....-------....60..--------..-----....70..-..-....80...----------...---------------------..90........100........110...-.....120.......130.......140.......150...--....160.......170.......180......-------.190--.-...-----...200.-....-..210.......220----..-----------...------...--------------------230------.-........-240.......250.......260-..-----.---.----....--270-----...-......280......-------..290.......300.....--------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ML
N
F
T
D
V
T
E
F
I
L
-----------------
L
G----------------LTSRRE
W
Q
V
L
---
F
F
I
I
F
----
L
V
-
V
Y
-------
I
--
I
T
M
VGNI
G
M
M
V
L
--
I
K
VSPQLNN-------
P
M
Y
F
F
L
S
H
--------
L
S
-----
F
V
D
V
W
FSS-NV-
T
P
K
M
L
E
N
L
L----------SDK---------------------KT
I
T
Y
A
G
C
L
V
Q
C
F
F
-
F
I
A
L
V
H
V
E
I
-
F
I
L
A
-
A
M
A
F
D
R
Y
M
AIGNPLLYGSKM
S
R
V
V
C
I
R
L
I
T
F
P
Y
I
Y
G
F
L
T
S
L
--
A
A
T
L
W
T
Y
G
L
Y
F
C
G
K
I
E
I
N
H
F
YCADP
P
L
I
K
M
ACA-------
G
T
F
V
--
K
-
E
Y
T
-----
M
I
I
L
AGI-
N
F
T
Y
-
S
L
T
V
I
I
I
S
Y
L
F
I
L
I
-----
A
I
-----------
L
R
M------RSA--------------------E--------
G
-
R
Q
K
A
F
S
T
C
-
G
S
H
L
T
A
V
I
I
F
Y
G
T
L
I
F
M
Y
LRRP--
T
E
-----
E
---
S
----
V
EQG--
K
-------
M
V
A
-
V
F
Y
T
T
V
I
-
P
M
L
N
P
M
I
-------
Y
S
L
R
N
K
D
V
K
K
A
M
M
K
V
I
SRSC--------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
89.07
17%
-148
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-
M
N
G
T
E
G
P
N
F
Y
V
PFSNKTGVVRSPFEAPQ
Y
Y
----------------
L
A
E
P
W
Q
F
S
M
L
---
A
A
Y
M
F
----
L
L
-
I
M
-------
L
--
G
F
P
I
N
F
L
T
L
Y
V
T
--
V
Q
H
K
K
-
L
R
T
-------
P
L
N
Y
I
L
L
N
--------
L
A
-----
V
A
D
L
F
M
V
F
-
G
G
-
F
T
T
T
L
Y
T
S
L
----------
H
G
Y
---------------------
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
-
W
S
L
V
-
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
--------------
N
F
R
F
G
E
N
H
A
I
M
G
--
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
--
N
-
E
S
F
-----
V
I
Y
M
F
V
V
-
H
F
I
I
-
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-----
T
V
-----------
K
E
A
------
A
A
S
--------------------
A
--------
T
-
T
Q
K
A
E
K
E
V
-
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
--
F
Y
-----
I
---
F
----
T
H
Q
G
--
S
DFGPIFM
T
I
P
-
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
-------
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
NPSTTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.68
23%
-134
- C3 -
4U14
1
ENLYS_BPT4
A:
[10-286]
-----------------------------------------------------
W
Q
V
V
---
F
-
I
A
F
----
L
T
-
G
F
-------
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
--
F
K
V
N
K
Q
L
K
T
-------
V
N
N
Y
F
L
L
S
--------
L
A
-----
C
A
D
L
I
I
G
V
-
I
S
-
M
N
L
F
T
T
Y
I
I
----------
M
N
R
---------------------
W
A
L
G
N
L
A
C
D
L
W
L
S
I
-
D
Y
V
A
S
N
A
S
V
-
M
N
L
L
-
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
--
P
A
I
L
--
F
W
Q
Y
F
V
G
K
R
T
V
-------
P
P
---
G
E
C
F
-------
I
Q
F
L
--
S
-
E
P
T
-----
I
T
F
G
T
A
I
A
A
F
Y
M
-
P
V
T
I
M
T
I
L
Y
W
R
I
Y
K
-----
E
T
-----------
E
K
M
N
C
F
E
M
L
R
I
D
--------------------
E
--------
G
L
R
L
K
I
Y
K
D
C
-
E
G
Y
Y
T
---
I
G
I
G
H
L
L
---
T
K
S
P
--
S
L
-----
N
---
A
----
A
K
S
E
--
L
-------
D
K
A
-
I
G
R
N
T
N
G
-
V
I
T
K
D
E
A
-------
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
80.58
18%
-144
- C3 -
2KS9
1
NK1R_HUMAN
A:
[35-323]
------------------------------------------------------------
W
A
A
A
Y
----
T
V
-
I
V
-------
V
--
T
S
V
V
G
N
V
V
V
M
W
I
--
I
L
A
H
K
R
M
R
T
-------
V
T
N
Y
F
L
V
N
--------
L
A
-----
F
A
E
A
S
M
A
A
-
F
N
-
T
V
V
N
F
T
Y
A
V
----------
H
N
E
---------------------
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
-
P
I
A
A
V
F
A
S
I
-
Y
S
M
T
-
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
--
P
Q
G
Y
Y
-
S
T
--
T
-
E
T
-
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
----------
N
K
I
Y
--
E
-
K
V
Y
-----
H
I
C
V
T
V
L
-
I
Y
F
L
-
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
-----
T
L
-----------
W
A
S
------
E
I
P
GDSSDRYH
E
Q
V
---------
S
--------
A
-
K
R
K
V
V
K
M
M
-
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
--
I
N
-----
P
---
D
LYL-
K
K
F
I
Q
-
Q
V
Y
-----
L
A
I
-
M
W
L
A
M
S
S
-
T
M
Y
N
P
I
I
-------
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
79.00
18%
-137
- C3 -
2Z73
5
OPSD_TODPA
A:
[34-333]
------------------------------------------------------
Y
Y
S
---
L
G
I
F
I
----
G
I
-
C
G
-------
I
--
I
G
C
G
G
N
G
I
V
I
Y
L
--
F
T
K
T
K
S
L
Q
T
-------
P
A
N
M
F
I
I
N
--------
L
A
-----
F
S
D
F
T
F
S
L
-
V
N
G
F
P
L
M
T
I
S
C
F
----------
L
K
K
---------------------
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
-
G
G
I
F
G
F
M
S
I
-
M
T
M
A
-
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
--
G
P
I
F
G
W
G
A
---
Y
T
L
-
E
G
V
L
C
N
C
S
F
D
Y
I
S
------------
R
D
S
T
--
T
-
R
S
N
-----
I
L
C
M
F
I
L
-
G
F
F
G
-
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
-----
S
V
-----------
S
N
H
------
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
--------
A
-
E
M
R
L
A
K
I
S
-
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
--
F
G
-----
P
LEW
V
----
T
P
Y
A
--
A
-------
Q
L
P
-
V
M
F
A
K
A
S
-
A
I
H
N
P
M
I
-------
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
76.32
15%
-115
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
P
-----------------
F
S
NKTGVVRSPFEAPQYY
L
A
E
P
W
Q
F
S
M
L
---
A
A
Y
M
F
----
L
L
-
I
M
-------
L
--
G
F
P
I
N
F
L
T
L
Y
V
T
--
V
Q
H
-
K
K
L
R
T
-------
P
L
N
Y
I
L
L
N
--------
L
A
-----
V
A
D
L
F
M
V
F
-
G
G
-
F
T
T
T
L
Y
T
S
L
----------
H
G
Y
---------------------
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
-
W
S
L
V
-
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
--------------
N
F
R
F
G
E
N
H
A
I
M
G
--
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
--
N
-
E
S
F
-----
V
I
Y
M
F
V
V
-
H
F
I
I
-
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-----
T
V
KEAAAQQQESA
T
T
Q
------
K
A
E
--------------------
K
--------
E
-
V
T
R
M
V
I
I
M
-
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
--
G
S
-----
D
---
F
----
G
P
I
F
--
M
-------
T
I
P
-
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
-------
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
NPLGDDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
76.17
16%
-138
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------------------------
D
E
V
W
V
V
G
---
M
G
I
V
M
----
S
L
-
I
V
-------
L
--
A
I
V
F
G
N
V
L
V
I
T
A
--
I
A
K
F
E
R
L
Q
T
-------
V
T
N
Y
F
I
T
S
--------
L
A
-----
C
A
D
L
V
M
G
L
-
A
V
-
V
P
F
G
A
A
H
I
L
----------
M
K
M
---------------------
W
T
F
G
N
F
W
C
E
F
W
T
S
I
-
D
V
L
C
V
T
A
S
I
-
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T
L
C
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V
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A
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D
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Y
F
A
I
T
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P
F
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Q
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L
L
T
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N
K
A
R
V
I
I
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M
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W
I
V
S
G
L
T
S
F
--
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P
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Q
--
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
-----
C
D
-------
F
F
T
N
--
Q
-
A
Y
A
-----
I
A
S
S
I
V
S
-
F
Y
V
P
-
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
-----
A
K
-----------
R
Q
L
------
N
I
F
--------------------
E
--------
M
-
L
R
I
D
E
G
L
R
-
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
--
P
S
-----
L
---
N
----
A
A
K
S
--
E
-------
L
D
K
-
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
-------
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
47
Fugue
74.29
17%
-156
- C2 -
4BZF
3
GALM_BACSU
A:
[1-322]
-
A
N
F
I
E
K
I
T
Y
L
G
-----------------
T
P
----------------
A
I
K
A
G
N
E
H
L
E
---
M
I
V
V
P
EWGS
N
V
-
I
S
-------
L
--
V
D
K
T
T
N
V
Q
L
L
R
E
--
P
E
T
A
E
S
F
H
D
T
PTLY
G
I
P
I
L
F
P
P
N
R
--------
I
S
DG
T
F
S
F
R
G
R
T
Y
H
F
-
D
I
-
N
E
K
D
K
H
N
H
L
HGFLYH
E
K
W
N
V
V
T
---------------------
T
K
Q
T
D
E
G
V
I
V
E
T
E
I
D
L
S
E
L
P
H
V
Q
K
Q
F
P
H
H
-
A
V
V
R
M
T
Y
T
I
K
E
N
T
L
F
---
K
H
A
T
V
M
N
K
G
K
E
A
F
P
W
G
I
G
Y
H
T
T
F
IF
P
A
E
S
S
L
F
S
L
T
A
D
Q
Q
W
E
L
D
E
R
L
L
P
T
G
K
L
M
D
V
P
------------------
Y
K
-----
E
A
L
H
E
G
M
-
D
L
R
H
K
Q
L
D
D
V
F
L
S
S
--------------------------------
Y
Q
K
--------------------
R
--------
G
-
G
E
N
Q
A
V
I
Y
-
H
Q
H
A
H
I
S
I
I
Y
K
A
D
E
Q
F
K
H
W
V
V
Y
--
N
A
-----
D
---
G
-----
K
Q
G
--
Y
-------
L
C
P
-
E
P
Y
T
W
V
T
-
N
A
V
N
L
D
L
PSSLTG
L
Q
V
L
E
P
G
E
E
T
T
A
K
S
S
I
T
I
E
L
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.22
22%
-164
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[8-207]
--------------------------------------------------------
V
---
Y
I
T
V
E
----
L
A
-
I
A
-------
V
--
L
A
I
L
G
N
V
L
V
C
W
A
--
V
W
L
N
S
N
L
Q
N
-------
V
T
N
Y
F
V
V
S
--------
L
A
-----
A
A
D
I
L
V
G
V
-
L
A
-
I
P
F
A
I
T
--
I
----------
S
T
G
---------------------
F
C
A
A
C
H
G
C
L
F
I
A
C
F
-
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
-
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
--
T
P
M
L
---
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
---------
L
F
E
--
D
-
V
V
P
-----
M
N
Y
M
V
Y
F
-
N
F
----
F
A
C
V
L
V
P
L
L
L
M
L
G
-----
V
Y
-----------
L
R
I
------
F
A
A
--------------------
A
--------
R
-
R
Q
L
K
Q
M
E
S
-
Q
P
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
--
A
I
-----
I
---
A
----
G
L
F
A
--
L
-------
C
W
L
-
P
L
H
I
I
N
C
-
F
T
F
F
C
P
D
-------
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.64
22%
-162
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[8-207]
--------------------------------------------------------
V
---
Y
I
T
V
E
----
L
A
-
I
A
-------
V
--
L
A
I
L
G
N
V
L
V
C
W
A
--
V
W
L
N
S
N
L
Q
N
-------
V
T
N
Y
F
V
V
S
--------
L
A
-----
A
A
D
I
L
V
G
V
-
L
A
-
I
P
F
A
I
T
--
I
----------
S
T
G
---------------------
F
C
A
A
C
H
G
C
L
F
I
A
C
F
-
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
-
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
--
T
P
M
L
---
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
---------
L
F
E
--
D
-
V
V
P
-----
M
N
Y
M
V
Y
F
-
N
F
----
F
A
C
V
L
V
P
L
L
L
M
L
G
-----
V
Y
-----------
L
R
I
------
F
A
A
--------------------
A
--------
R
-
R
Q
L
K
Q
M
E
S
-
Q
P
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
--
A
I
-----
I
---
A
----
G
L
F
A
--
L
-------
C
W
L
-
P
L
H
I
I
N
C
-
F
T
F
F
C
P
D
-------
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.41
22%
-162
- C3 -
3PWH
1
?
A:
[8-207]
--------------------------------------------------------
V
---
Y
I
T
V
E
----
L
A
-
I
A
-------
V
--
L
A
I
L
G
N
V
L
V
C
W
A
--
V
W
L
N
S
N
L
Q
N
-------
V
T
N
Y
F
V
V
S
--------
L
A
-----
A
A
D
I
L
V
G
V
-
L
A
-
I
P
F
A
I
T
--
I
----------
S
T
G
---------------------
F
C
A
A
C
H
G
C
L
F
I
A
C
F
-
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
-
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
--
T
P
M
L
---
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
---------
L
F
E
--
D
-
V
V
P
-----
M
N
Y
M
V
Y
F
-
N
F
----
F
A
C
V
L
V
P
L
L
L
M
L
G
-----
V
Y
-----------
L
R
I
------
F
A
A
--------------------
A
--------
R
-
R
Q
L
K
Q
M
E
S
-
Q
P
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
--
A
I
-----
I
---
A
----
G
L
F
A
--
L
-------
C
W
L
-
P
L
H
I
I
N
C
-
F
T
F
F
C
P
D
-------
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.21
22%
-163
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[8-207]
--------------------------------------------------------
V
---
Y
I
T
V
E
----
L
A
-
I
A
-------
V
--
L
A
I
L
G
N
V
L
V
C
W
A
--
V
W
L
N
S
N
L
Q
N
-------
V
T
N
Y
F
V
V
S
--------
L
A
-----
A
A
D
I
L
V
G
V
-
L
A
-
I
P
F
A
I
T
--
I
----------
S
T
G
---------------------
F
C
A
A
C
H
G
C
L
F
I
A
C
F
-
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
-
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
--
T
P
M
L
---
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
---------
L
F
E
--
D
-
V
V
P
-----
M
N
Y
M
V
Y
F
-
N
F
----
F
A
C
V
L
V
P
L
L
L
M
L
G
-----
V
Y
-----------
L
R
I
------
F
A
A
--------------------
A
--------
R
-
R
Q
L
K
Q
M
E
S
-
Q
P
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
--
A
I
-----
I
---
A
----
G
L
F
A
--
L
-------
C
W
L
-
P
L
H
I
I
N
C
-
F
T
F
F
C
P
D
-------
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
72.78
22%
-164
- C3 -
3REY
1
AA2AR_HUMAN
A:
[8-207]
--------------------------------------------------------
V
---
Y
I
T
V
E
----
L
A
-
I
A
-------
V
--
L
A
I
L
G
N
V
L
V
C
W
A
--
V
W
L
N
S
N
L
Q
N
-------
V
T
N
Y
F
V
V
S
--------
L
A
-----
A
A
D
I
L
V
G
V
-
L
A
-
I
P
F
A
I
T
--
I
----------
S
T
G
---------------------
F
C
A
A
C
H
G
C
L
F
I
A
C
F
-
V
L
V
L
A
Q
S
S
I
-
F
S
L
L
-
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
--
T
P
M
L
---
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
---------
L
F
E
--
D
-
V
V
P
-----
M
N
Y
M
V
Y
F
-
N
F
----
F
A
C
V
L
V
P
L
L
L
M
L
G
-----
V
Y
-----------
L
R
I
------
F
A
A
--------------------
A
--------
R
-
R
Q
L
K
Q
M
E
S
-
Q
P
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
--
A
I
-----
I
---
A
----
G
L
F
A
--
L
-------
C
W
L
-
P
L
H
I
I
N
C
-
F
T
F
F
C
P
D
-------
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
68.78
21%
-168
- C3 -
3EML
8
ENLYS_BPT4
A:
[22-221]
-------------------------------------------------------
S
V
---
Y
I
T
V
E
----
L
A
-
I
A
-------
V
--
L
A
I
L
G
N
V
L
V
C
W
A
--
V
W
L
N
S
N
L
Q
N
-------
V
T
N
Y
F
V
V
S
--------
L
A
-----
A
A
D
I
A
V
G
V
-
L
A
-
I
P
F
A
I
T
I
S
T
------------
G
---------------------
F
C
A
A
C
H
G
C
L
F
I
A
C
F
-
V
L
V
L
T
Q
S
S
I
-
F
S
L
L
-
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
--
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
---
Q
V
A
C
L
-------
F
E
D
V
VP
M
-
N
Y
M
-----
V
Y
F
N
F
F
A
-
C
V
L
V
-
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
-----
A
A
-----------
R
R
Q
------
L
N
I
--------------------
F
--------
E
-
M
L
R
I
D
E
G
L
-
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
P
-----
S
---
L
----
N
A
A
K
--
S
-------
E
L
D
-
K
A
I
G
R
N
T
-
N
G
V
I
T
K
D
-------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
67.74
13%
-122
- C3 -
1U19
14
OPSD_BOVIN
A:
[41-324]
-------------------------------------------------------
S
M
---
L
A
A
Y
M
----
F
L
-
L
I
-------
M
--
L
G
F
P
I
N
F
L
T
L
Y
V
--
T
V
Q
H
K
K
L
R
T
-------
P
L
N
Y
I
L
L
N
--------
L
A
-----
V
A
D
L
F
M
V
F
-
G
G
-
F
T
T
T
L
Y
T
S
L
----------
H
G
Y
---------------------
F
V
F
G
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
-
W
S
L
V
-
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--
P
P
L
V
G
W
S
R
--
Y
-
I
P
-
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
--
E
-------
E
T
N
N
--
E
-
S
F
V
-----
I
Y
M
F
-
V
V
-
H
F
I
I
-
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-----
T
V
-----------
K
E
A
------
A
A
Q
--------------------
Q
QESA
T
T
Q
K
A
-
E
K
E
V
T
R
M
V
-
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
-----
S
---
D
F---
G
P
I
F
--
M
-------
T
I
P
-
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
-------
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
66.05
20%
-152
- C3 -
2RH1
6
ADRB2_HUMAN (first)
A:
[40-235]
------------------------------------------------------
V
V
G
---
M
G
I
V
M
----
S
L
-
I
V
-------
L
--
A
I
V
F
G
N
V
L
V
I
T
A
--
I
A
K
F
E
R
L
Q
T
-------
V
T
N
Y
F
I
T
S
--------
L
A
-----
C
A
D
L
V
M
G
L
-
A
V
-
V
P
F
G
A
A
H
I
L
----------
M
K
M
---------------------
W
T
F
G
N
F
W
C
E
F
W
T
S
I
-
D
V
L
C
V
T
A
S
I
-
E
T
L
C
-
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
--
L
P
I
Q
M
H
W
Y
-
R
A
---
T
H
Q
E
A
I
N
C
Y
A
----
E
E
T
C
C
-------
D
F
F
T
--
N
-
Q
A
Y
-----
A
I
A
S
S
I
V
-
S
F
Y
V
-
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
-----
E
A
-----------
K
R
Q
------
L
N
I
--------------------
F
--------
E
-
M
L
R
I
D
E
G
L
-
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
P
-----
S
---
L
----
N
A
A
K
--
S
-------
E
L
D
-
K
A
I
G
R
N
T
-
N
G
V
I
T
K
D
-------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
65.47
16%
-127
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
------------------------------------------------------
K
Y
V
---
V
I
I
A
Y
----
A
L
-
V
F
-------
L
--
L
S
L
L
G
N
S
L
V
M
L
V
--
I
L
Y
S
R
V
G
R
S
-------
V
T
D
V
Y
L
L
N
--------
L
A
-----
L
A
D
L
L
F
A
L
--
T
-
L
P
I
W
A
A
S
K
-----------
V
N
G
---------------------
W
I
F
G
T
F
L
C
K
V
V
S
L
L
-
K
E
V
N
F
Y
S
G
I
-
L
L
L
A
-
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
--
P
F
F
L
F
R
Q
A
---
Y
H
P
N
-
N
S
S
P
V
C
Y
E
V
L
G
N
D
-----------
T
A
K
W
--
R
-
M
V
L
-----
R
I
L
P
H
T
F
-
G
F
I
V
-
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
-----
T
L
-----------
F
K
A
-------
H
M
--------------------
G
--------
Q
-
K
H
R
A
M
R
V
I
-
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
--
L
M
RTQVI
Q
E--
S
C
E
R
R
N
N
I
G
R
A
L
-------
D
A
T
-
E
I
L
G
F
L
H
-
S
C
L
N
P
I
I
-------
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
63.44
23%
-174
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[8-148]
--------------------------------------------------------
V
---
Y
I
T
V
E
----
L
A
-
I
A
-------
V
--
L
A
I
L
G
N
V
L
V
C
W
A
--
V
W
L
N
S
N
L
Q
N
-------
V
T
N
Y
F
V
V
S
--------
L
A
-----
A
A
D
I
A
V
G
V
-
L
A
-
I
P
F
A
I
T
--
I
----------
S
T
G
---------------------
F
C
A
A
C
H
G
C
L
F
I
A
C
F
-
V
L
V
L
T
Q
S
S
I
-
F
S
L
L
-
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
--
T
P
M
L
---
G
W
N
N
C
G
Q
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
-------
N
Y
M
V
--
Y
-
F
N
F
-----
F
A
C
V
L
V
P
-
L
L
L
M
-
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
-----
L
K
-----------
Q
M
E
------
S
Q
P
--------------------
L
--------
P
-
G
E
R
A
R
S
T
L
-
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
--
P
L
-----
H
---
I
----
I
N
C
F
--
T
-------
F
F
C
-
P
D
C
S
H
A
P
-
L
W
L
M
Y
L
A
-------
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
63.00
19%
-157
- C3 -
3UON
2
ACM2_HUMAN (first)
A:
[24-215]
-------------------------------------------------------
V
F
---
I
V
L
V
A
----
G
S
-
L
S
-------
L
--
V
T
I
I
G
N
I
L
V
M
V
S
--
I
K
V
N
R
H
L
Q
T
-------
V
N
N
Y
F
L
F
S
--------
L
A
-----
C
A
D
L
I
I
G
V
-
F
S
-
M
N
L
Y
T
L
Y
T
V
----------
I
G
Y
---------------------
W
P
L
G
P
V
V
C
D
L
W
L
A
L
-
D
Y
V
V
S
N
A
S
V
-
M
N
L
L
-
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
--
P
A
I
L
F
W
Q
F
--
I
V
G
V
R
T
V
E
D
G
E
C
----------
Y
-------
I
Q
F
F
--
S
N
A
A
V
-----
T
F
G
T
A
I
A
-
A
F
Y
L
-
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
-----
A
S
-----------
K
S
R
------
I
N
I
--------------------
F
--------
E
-
M
L
R
I
D
E
G
L
-
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
P
-----
S
---
L
----
N
A
A
K
--
S
-------
E
L
D
-
K
A
I
G
R
N
T
-
N
G
V
I
T
K
D
-------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
62.51
25%
-167
- C3 -
4DAJ
2
ACM3_RAT (first)
A:
[10-165]
-----------------------------------------------------
W
Q
V
V
---
F
-
I
A
F
----
L
T
-
G
F
-------
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
--
F
K
V
N
K
Q
L
K
T
-------
V
N
N
Y
F
L
L
S
--------
L
A
-----
C
A
D
L
I
I
G
V
-
I
S
-
M
N
L
F
T
T
Y
I
I
----------
M
N
R
---------------------
W
A
L
G
N
L
A
C
D
L
W
L
S
I
-
D
Y
V
A
S
N
A
S
V
-
M
N
L
L
-
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
--
P
A
I
L
--
F
W
Q
Y
F
V
G
K
R
T
V
P
P
G
E
C
F
I
Q
F
L
S
E
P
T
I
T
-------
F
G
T
A
--
I
-
A
A
F
-----
Y
M
P
V
T
I
M
-
T
I
L
Y
-
W
R
I
Y
K
E
T
E
K
M
N
I
F
E
-----
M
L
-----------
R
I
D
------
E
G
L
--------------------
R
--------
L
-
K
I
Y
K
D
T
E
G
-
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
--
L
D
-----
K
---
A
----
I
G
R
N
--
T
-------
N
G
V
-
I
T
K
D
E
A
E
-
K
L
F
N
Q
D
V
-------
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
62.03
17%
-173
* C2 *
4Q98
1
FIMA_PORGI
A:
[9-365]
V
V
E
T
N
A
T
V
S
F
I
I
-----------------
K
S
----------------
G
E
S
R
A
V
G
D
D
L
T
D
A
K
I
T
K
L
----
T
A
M
V
Y
AGQVQE
G
I
--
K
T
V
E
E
D
G
G
V
L
K
V
EG
I
P
C
K
S
G
A
N
R
-------
V
L
V
V
V
A
N
H
NYELTGKS
L
N
-----
E
V
E
A
L
T
T
S
L
T
A
-
E
N
Q
N
A
K
N
L
I
M
---------
T
G
K
S
A
A
F
T
I
K
P
G
S
N
H
Y
GYPGGTAS
D
N
L
V
S
A
G
T
P
L
A
V
T
R
-
V
H
A
G
I
S
F
A
G
-
V
E
V
N
M
A
T
Q
Y
Q
N
Y
Y
S
------
F
K
P
A
D
A
K
I
A
A
L
V
A
K
K
D
S
K
I
F
G
--
N
S
L
--
V
S
N
---
T
N
A
Y
L
Y
G
V
Q
T
P
A
G
L
Y
T
P
D
A
A
G
E
T
Y
E
L
E
-------
A
S
L
N
--
T
-
N
Y
A
VG
A
G
F
Y
V
L
E
S
K
Y
-
D
A
S
N
-
E
L
R
P
T
I
L
C
I
Y
G
K
L
L
DKDGN
P
L
-----------
T
E
P
------
A
L
T
--------------------
D
--------
A
-
I
N
A
G
F
C
D
G
D
G
T
T
Y
Y
P
V
L
V
N
Y
D
G
N
G
Y
I
Y
S
G
A
I
--
T
Q
-----
G
----------
Q
N
--
K
-------
I
V
R
N
N
H
Y
K
I
S
L
-
N
I
T
G
P
G
T
-------
N
T
P
E
N
P
Q
P
V
Q
A
N
L
N
V
T
C
Q
V
T
P
W
V
VVNQ-------------------------------------------------------------------------------------------------------------------------------------------------------