@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR5R1_HUMAN: (2016-01-13 )
MAEVNIIYVTVFILKGITNRPELQAPCFGVFLVIYLVTVLGNLGLITLIKIDTRLHTPMYYFLSHLAFVDLCYSSAITPKMMVNFVVERNTIPFHACATQLGCFLTFMITECFLLASMAYDCYVAICSPLHYSTLMSRRVCIQLVAVPYIYSFLVALFHTVITFRLTYCGPNLINHFYCDDLPFLALSCSDTHMKEILIFAFAGFDMISSSSIVLTSYIFIIAAILRIRSTQGQHKAISTCGSHMVTVTIFYGTLIFMYLQPKSNHSLDTDKMASVFYTVVIPMLNPLIYSLRNKEVKDASKKALDKGCENLQILTFLKIRKLY
Atome Classification :
(20 SA)
------------.--........10.......-.20-----------........30.-.......------40.--.......50........60........70......-..80.....-...90........100..------.--....110.......120.......130...---....140.------------......150.......160----.........170---.....-..180.......190.--......200......----------.210......--.220-----........230----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------........240----........250.....----..260...------------.------------.------..270.......280.......290.......300...---------....310.......320..-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------M--A
E
V
N
I
I
Y
V
T
V
F
I
L
KGIT-NRP-----------ELQA
P
C
F
G
V
F
L
-
V
I
Y
L
V
T
V
------LGN--L
G
L
I
T
L
I
K
I
D
T
R
LH
T
P
M
Y
Y
F
L
S
H
L
A
F
V
D
L
C
Y
SSAI-
T
P
K
M
M
V
N
F
V
-
V
ERNTI
P
F
H
A
C
A
T
Q
L
G
C
F
------
L
--
T
F
M
I
T
E
C
F
L
L
A
S
M
A
Y
D
C
Y
V
A
I
CS
P
L
H
Y
S
T
L
---
M
S
R
R
V
C
I
Q
------------
L
V
A
V
P
Y
I
Y
S
F
L
V
A
L
F
H
T
------
V
I
T
F
R
L
T
YC
G
P
N
---
L
I
N
H
F-YCDDL
P
F
L
A
LSCS
D
T
H
--
M
K
E
I
L
I
F
A
FAGFDMI----------SSS
S
I
V
L
T
S
Y
--
I
F
I
------
I
A
A
I
L
R
I
RS------------------------------------------------------------------------------------------------------------------------------------------------------------------T-------------------------------------------------------------------------------------------------------------------------------------------------------------------QG
Q
H
K
A
I
S
TC-----GS
H
M
V
T
V
T
I
F
Y
G
T
L
I
F
----
M
Y
LQPKSN------------H------------S------L
D
T
D
K
M
A
S
V
F
Y
T
V
V
I
P
M
L
N
P
L
I
Y
S
L
RN
K
E
V
K
D
A
S
K
K
A
L
---------
D
KGCEN
L
Q
I
L
T
F
L
K
I
RKLY-------
24
HHSearch
87.15
21%
-139
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-------------------------------------------------
V
V
G
M
G
I
V
M
S
-
L
I
V
L
A
I
V
------
F
G
N
--
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
------
V
--
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
------------
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
------
Q
M
H
W
Y
R
A
----
T
---
H
Q
E
A
I
-
N
C
Y
A
E
----
E
T
C
C
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
----------
V
P
L
V
I
M
V
F
V
Y
--
S
R
V
------
F
Q
E
A
K
R
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
H
K
A
L
K
T
L
-----
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
----
V
N
I
V
H
V
I
Q
------------
D
NL----------
I
------
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
---------
C
L
------------------------
23
HHSearch
84.51
18%
-139
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
---------------------------------------------------
P
L
V
V
V
L
S
-
T
I
C
L
V
T
V
------
G
L
N
--
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
------
Y
--
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
------------
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
------
G
-
W
N
H
-----------
R
R
E
D
-
K
C
E
T
D
F
Y
D
-----------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
----------
L
P
T
L
L
M
L
W
F
Y
--
A
K
I
------
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
K
A
A
K
Q
L
-----
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
----
F
F
M
V
I
A
F
C
------------
K
NC----------
C
------
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
---------
H
I
------------------------
28
HHSearch
84.00
16%
-137
* C2 *
2Z73
5
OPSD_TODPA
A:
[32-333]
-----------------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
-
I
C
G
I
I
G
C
------
G
G
N
--
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
------
G
--
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
------------
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
------
F
G
W
G
A
----
Y
T
L
---
E
G
V
L
C
-
N
C
S
F
D
Y
I
S
R
-----
D
S
--
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
----------
G
P
I
L
I
I
F
F
C
Y
--
F
N
I
------
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
A
K
I
S
-----
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
----
V
A
L
L
A
Q
F
G
------------
P
LEW---------
V
------
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
---------
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
-------
21
HHSearch
82.52
19%
-140
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
--------------------------------------------------
V
F
I
V
L
V
A
G
-
S
L
S
L
V
T
I
------
I
G
N
--
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
------
Y
--
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
------------
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
------
L
F
W
Q
F
I
V
--
G
V
R
---
T
V
E
D
G
-
E
C
Y
I
Q
F
F
-----------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
----------
L
P
V
I
I
M
T
V
L
Y
--
W
H
I
------
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
K
V
T
R
T
I
-----
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
----
M
V
L
I
N
T
F
C
------------
A
PC----------
I
------
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
---------
M
-------------------------
39
Fugue
79.98
16%
-121
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
-
R
S
P
FEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
-
L
L
I
M
L
G
F
------
P
I
N
--
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
------
T
--
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
---
F
G
E
N
H
A
I
M
------------
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
VGW
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
-------
Y
-
Y
T
P
H
--------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
----------
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
------
V
K
E
A
A
A
S
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
----
I
F
T
H
Q
G
S
D
------------
F
------------
G
------
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
-
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
---------
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A-----
27
HHSearch
78.82
18%
-144
- C2 -
3EML
13
ENLYS_BPT4
A:
[21-472]
-------------------------------------------------
S
S
V
Y
I
T
V
E
L
-
A
I
A
V
L
A
I
------
L
G
N
--
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
------
L
--
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
------------
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
------
L
G
W
N
N
C
G
Q
----------
S
Q
-
G
C
G
E
G
Q
V
---
A
C
L
F
E
D
VV
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
----------
V
P
L
L
L
M
L
G
V
Y
--
L
R
I
------
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
L
-----
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
----
I
N
C
F
T
F
F
C
PDCS--------
H
------------
A
------
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
---------
R
S
H
V
L
R
Q
-------------------
31
HHSearch
76.56
16%
-138
- C2 -
2KS9
1
NK1R_HUMAN
A:
[33-326]
--------------------------------------------------
V
L
W
A
A
A
Y
T
-
V
I
V
V
T
S
V
------
V
G
N
--
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
------
I
--
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
------------
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
------
Y
Y
S
T
T
-----
E
T
---
M
P
S
R
V
-
V
C
M
I
E
W
P
E
H
P
---
N
K
I
--
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
----------
L
P
L
L
V
I
G
Y
A
Y
--
T
V
V
------
G
I
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
V
K
M
M
-----
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
----
F
F
L
L
P
Y
I
N
------------
P
------------
D
LYLKKF
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
---------
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
-------
32
HHSearch
76.54
17%
-143
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------------------
Y
A
L
S
Y
C
-
A
L
I
L
A
I
V
------
F
G
N
--
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
------
V
--
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
------------
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
------
F
G
F
N
T
----------
T
G
D
P
T
-
V
C
S
I
S
N
------------
P
-
D
-
F
V
I
Y
S
S
V
V
S
F
Y
----------
L
P
F
G
V
T
V
L
V
Y
--
A
R
I
------
Y
V
V
L
K
Q
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
T
Q
M
V
-----
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
----
T
H
V
L
N
T
H
C
------------
Q
TCH---------
V
------
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
---------
S
C
------------------------
22
HHSearch
75.49
15%
-135
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-499]
-----------------------------------------------
F
N
K
I
F
L
P
T
I
Y
S
-
I
I
F
L
T
G
I
------
V
G
N
--
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
------
T
--
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
------------
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
------
I
F
A
N
V
-----
S
E
---
A
D
D
R
Y
-
I
C
D
R
F
Y
P
N
------
D
L
--
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
----------
L
P
G
I
V
I
L
S
C
Y
--
C
I
I
------
I
S
K
L
S
H
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
-----
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
----
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
------------
T
------
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
---------
T
S
G
R
P
L
E
V
L
F
Q
---------------
29
HHSearch
73.02
17%
-138
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
-----------------------------------
E
-----------
N
S
I
K
L
T
S
V
V
F
I
-
L
I
C
C
F
I
I
------
L
E
N
--
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
------
F
--
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
------------
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
------
M
G
W
N
C
----------
I
S
A
L
S
-
S
C
S
T
V
L
P
L
-------
Y
---
H
K
H
Y
I
L
-
F
C
T
T
V
F
T
----------
L
L
L
L
S
I
V
I
L
Y
--
C
R
I
------
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
A
L
L
K
T
V
-----
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
----
L
L
L
L
D
V
G
C
------------
K
------------
V
KTC
D
--
I
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
---------
G
R
P
L
----------------------
30
HHSearch
67.17
14%
-121
- C2 -
1U19
14
OPSD_BOVIN
A:
[39-330]
------------------------------------------------
Q
F
S
M
L
A
A
Y
M
F
-
L
L
I
M
L
G
F
------
P
I
N
--
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
------
T
--
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
------------
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
------
V
G
W
S
R
--
Y
--
I
P
---
E
G
M
Q
C
-
S
C
G
I
D
Y
Y
T
P
H
---
E
E
T
--
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
----------
I
P
L
I
V
I
F
F
C
Y
--
G
Q
L
------
V
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
V
-----
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
----
V
A
F
Y
I
F
T
H
QGS---------
D
------------
F
------
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
---------
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
-------
33
HHSearch
65.92
16%
-117
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
-----------------------------------------------
L
N
K
Y
V
V
I
I
A
Y
A
-
L
V
F
L
L
S
L
------
L
G
N
--
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
A
S
K
--
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
------
E
--
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
Q
----
K
R
H
L
V
K
F
------------
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
------
L
F
R
Q
A
--
Y
--
H
P
---
N
N
S
S
P
-
V
C
Y
E
V
L
G
N
D
----
T
A
K
--
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
----------
V
P
L
F
V
M
L
F
C
Y
--
G
F
T
------
L
R
T
L
F
K
A
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
M
R
V
I
-----
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
----
V
L
L
A
D
T
L
M
------------
R
TQVIQE
S
C
E
R
R
N
N
------
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
---------
A
M
H
G
----------------------
40
Fugue
63.29
11%
-93
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVP
F
--
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
-----------
W
Q
F
S
M
L
A
A
Y
M
F
-
L
L
I
M
L
G
F
------
P
I
N
--
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
------
T
--
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
------------
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
YYT
P
H
E
E
T
-
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
--
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
----------
V
K
E
A
A
A
Q
Q
Q
-------------
E
S
A
T
T
Q
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
T
R
M
V
I
I
M
-----
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
----
Y
I
F
T
H
Q
G
S
------------
D
------------
F
------
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGD
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------
48
Fugue
62.61
13%
-147
- C1 -
1D2R
-
SYW_GEOSE
A:
[1-326]
--------------------------------------------------------
M
K
-
T
I
F
S
G
I
Q
PSGVIT
I
G
N
Y
I
G
A
L
R
Q
F
V
E
L
Q
H
-
E
Y
N
C
Y
F
C
I
V
D
Q
H
A
I
T
V
-----------
W
Q
D
P
H
E
-
L
R
Q
N
I
R
R
L
A
A
L
Y
L
A
V
G
I
D
------
P
TQ
A
T
L
F
I
Q
S
E
V
P
---
A
H
A
Q
A
A
W
M
L
Q
C
I
V
Y
I
G
E
---
L
E
R
M
T
Q
F
K
E
K
S
A
G
A
AAAA
A
G
L
L
T
Y
P
P
L
M
A
A
D
I
L
L
Y
----------
N
T
D
I
V
P
V
G
E
D
---
Q
K
Q
H
I
E
L
T
R
D
L
A
E
R
F
N
K
R
Y
G
E
L
--
F
T
I
P
E
A
R
I
P
K
V
G
A
R
I
M
S
LVDPTKKM
S
K
S
D
P
N
P
K
A
Y
--
I
T
L
LDD
A
K
T
I
E
K
K
I
K
S
A
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
E
G
T
I
R
Y
D
K
-----
E
A
K
P
G
I
S
N
L
L
N
I
Y
S
T
L
S
GQS
I
E
E
L
E
R
Q
Y
------------
E
------------
G
------
K
G
Y
G
V
F
K
A
D
L
A
Q
V
V
I
E
T
L
R
P
I
Q
E
R
Y
H
H
W
M
E
S
E
E
L
D
R
V
L
---------
D
E
G
A
E
K
A
N
R
V
A
S
E
M
V
R
K
M
E
Q
A
M
GLGR
10
PsiBlast_PDB
59.22
26%
-154
- C2 -
3KJ6
1
ADRB2_HUMAN
A:
[36-204]
----------------------------------------------------
G
M
G
I
V
M
S
L
I
V
L
A
I
V
------
F
G
N
--
V
L
V
I
T
A
I
A
-
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
-----------------
F
W
T
S
I
D
------
V
--
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
------------
I
I
L
M
V
W
I
V
S
G
L
T
S
S
I
V
S
------
F
Y
V
P
L
V
I
M
V
F
V
Y
---
S
R
V
F
Q
-
E
A
K
R
Q
L
Q
K
I
D
K
S
E
G
R
F
--
H
V
K
F
C
L
K
E
H
K
A
L
K
T
L
----------
G
I
I
M
G
T
F
T
L
C
--
W
L
P
------
F
F
I
V
Y
I
L
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Y
V
N
S
G
F
N
P
-----
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
----
L
C
L
R
R
S
S
----------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
58.17
26%
-178
- C2 -
4EIY
18
AA2AR_HUMAN (first)
A:
[37-162]
-------------------------------------------------------
V
E
L
-
A
I
A
V
L
A
I
------
L
G
N
--
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
-----
F
A
-
I
---
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
--
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
------------
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
------
L
G
W
N
N
C
G
Q
P
K
E
G
---
K
N
H
S
Q
-
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
----------
P
L
L
L
M
L
G
V
Y
L
--
R
I
F
------
L
A
A
R
R
Q
L
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
N
W
E
T
L
N
D
N
-----
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
----
L
T
K
M
R
A
A
A
------------
L
------------
D
------
A
Q
K
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
---------
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
E
R
A
R
S
-------
7
PsiBlast_PDB
57.25
26%
-151
- C2 -
2R4S
-
ADRB2_HUMAN
A:
[37-203]
------------------------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
------
F
G
N
--
V
L
V
I
T
A
I
A
-
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
------------------
F
W
T
S
I
D
------
V
--
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
------------
I
I
L
M
V
W
I
V
S
G
L
T
S
S
I
V
S
------
F
Y
V
P
L
V
I
M
V
F
V
Y
---
S
R
V
F
Q
-
E
A
K
R
Q
L
Q
K
I
D
K
S
E
G
R
F
--
H
V
F
C
L
K
E
H
K
A
L
K
T
L
G
----------
I
I
M
G
T
F
T
L
C
W
--
L
P
F
------
F
I
L
N
W
I
G
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
F
N
P
L
I
Y
C
R
-----
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
R
R
----
S
S
L
K
-------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
56.59
26%
-153
- C2 -
2R4R
-
ADRB2_HUMAN
A:
[37-203]
------------------------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
------
F
G
N
--
V
L
V
I
T
A
I
A
-
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
------------------
F
W
T
S
I
D
------
V
--
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
------------
I
I
L
M
V
W
I
V
S
G
L
T
S
S
I
V
S
------
F
Y
V
P
L
V
I
M
V
F
V
Y
---
S
R
V
F
Q
-
E
A
K
R
Q
L
Q
K
I
D
K
S
E
G
R
F
--
H
V
F
C
L
K
E
H
K
A
L
K
T
L
G
----------
I
I
M
G
T
F
T
L
C
W
--
L
P
F
------
F
I
L
N
W
I
G
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
F
N
P
L
I
Y
C
R
-----
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
R
R
----
S
S
L
K
-------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
55.55
26%
-154
- C2 -
3PDS
4
ADRB2_HUMAN (first)
A:
[5-141]
-----------------------------------
D
-----------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
------
F
G
N
--
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
------
V
--
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
------------
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
------
Q
M
H
W
Y
R
A
T
H
Q
E
A
---
I
N
C
Y
A
-
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
--
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
----------
V
Y
S
R
V
F
Q
E
A
K
--
R
Q
L
------
N
I
F
E
M
L
R
I
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
R
L
K
I
Y
K
D
T
-----
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
----
S
L
N
A
A
K
S
E
------------
L
------------
D
------
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
---------
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
-------
9
PsiBlast_PDB
55.45
26%
-156
- C2 -
2RH1
5
ADRB2_HUMAN (first)
A:
[36-172]
-----------------------------------
D
-----------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
------
F
G
N
--
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
------
V
--
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
------------
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
------
Q
M
H
W
Y
R
A
T
H
Q
E
A
---
I
N
C
Y
A
-
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
--
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
----------
V
Y
S
R
V
F
Q
E
A
K
--
R
Q
L
------
N
I
F
E
M
L
R
I
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
R
L
K
I
Y
K
D
T
-----
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
----
S
L
N
A
A
K
S
E
------------
L
------------
D
------
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
---------
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
-------