@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR8D2_HUMAN: (2016-01-14 )
MATSNHSSGAEFILAGLTQRPELQLPLFLLFLGIYVVTVVGNLGMIFLIALSSQLYPPVYYFLSHLSFIDLCYSSVITPKMLVNFVPEENIISFLECITQLYFFLIFVIAEGYLLTAMEYDRYVAICRPLLYNIVMSHRVCSIMMAVVYSLGFLWATVHTTRMSVLSFCRSHTVSHYFCDILPLLTLSCSSTHINEILLFIIGGVNTLATTLAVLISYAFIFSSILGIHSTEGQSKAFGTCSSHLLAVGIFFGSITFMYFKPPSSTTMEKEKVSSVFYITIIPMLNPLIYSLRNKDVKNALKKMTRGRQSS
Atome Classification :
(20 SA)
-------------------------....-.--------....10........20.....----------------...30.---------------.......40-........50.-.......60........--70......-..---80..-..--------.-...90---........100....---...110........120-----------........130.----...---....140.....--..150.......----------------160..-------.....170.......---------------------------180..-.--....--------190-----...--......200.......210.......220.----------......230----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------........240..--------.....-250.----..-....260.-..------------.----.------------..270.....-.-.280.......290.......300.......310-----------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------MATS-N--------HSS
G
A
E
F
I
L
A
GLTQRPELQ
L
P
----------------
L
F
L
L
F
L
---------------
G
I
Y
V
V
T
V
VG-N
L
G
M
I
F
L
I
A
L
S
-SQLY
P
P
V
Y
Y
F
L
S
H
L
S
F
I
--
D
L
C
Y
S
SVI-
T
P
---
K
M
L
V
-NF--------V-
P
E
E
N
I
---
I
S
F
L
E
C
I
T
Q
L
Y
F
F
L
I
---
F
V
I
A-E
G
Y
L
L
T
A
M
EY
D
------------
R
Y
V
A
I
C
R
P
L
L
-
Y
----
N
I
V
---
M
S
H
R
V
C
S
I
M
M
A
V
--
V
Y
S
L
G
F
L
W
A
T
V
H
----------------
T
T
R
M
S
-------
V
L
S
F
C
R
SH
T
V
S
H
Y
F
C
---------------------------
D
I
L
P
L
-
L
--TLSC--------S-------S
T
H
--
I
N
E
I
L
L
F
I
IG
G
V
N
T
L
A
T
T
L
A
V
L
I
S
Y
A
F
I
F
S
----------
S
I
L
GIHS------------------------------------------------------------------------------------------------------------------------------------------------------------------T-------------------------------------------------------------------------------------------------------------------------------------------------------------------EGQS
K
A
F
G
T
C
S
S
H
--------
L
L
A
V
G
-
I
FFG----
S
I
-
T
F
M
Y
F
KPP-SS------------T----
T
------------
M
E
K
E
KVS
S
V
F
-
Y
-
I
T
I
I
P
M
L
N
P
L
I
Y
S
L
RN
K
D
V
K
N
A
L
K
K
M
TRGRQSS------------------------------------------------------------------------------
24
HHSearch
87.63
20%
-148
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-----------------------------------------------------------
P
----------------
L
V
V
V
L
S
---------------
T
I
C
L
V
T
V
G
L
-
N
L
L
V
L
Y
A
V
R
S
E
-
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
--
D
L
I
V
G
A
V
V
-
M
P
---
M
N
I
L
-
Y
L
--------
L
-
M
S
K
W
S
---
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
---
A
S
T
A
-
S
I
F
S
V
F
I
L
C
I
D
------------
R
Y
R
S
V
Q
Q
P
L
R
-
Y
----
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
--
A
W
F
L
S
F
L
W
V
I
P
I
----------------
L
G
W
-
N
-------
H
--------
R
R
E
D
K
C
---------------------------
E
T
D
F
Y
-
D
----------------------------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
----------
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
K
A
A
K
Q
L
G
F
I
--------
M
A
A
F
I
-
L
C
W
I
----
P
Y
-
F
I
F
F
M
V
I
A
-
F
C
------------
K
NC--
C
------------
N
E
H
L
H
M
F
T
I
W
-
L
-
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
----------------------------------------------------------------------------------
29
HHSearch
86.75
17%
-141
- C4 -
2Z73
5
OPSD_TODPA
A:
[32-332]
-------------------------------------------------------
A
V
Y
Y
S
----------------
L
G
I
F
I
G
---------------
I
C
G
I
I
G
C
G
G
-
N
G
I
V
I
Y
L
F
T
K
T
-
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
--
D
F
T
F
S
L
V
N
G
F
P
---
L
M
T
I
-
S
C
--------
F
-
L
K
K
W
I
---
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
---
F
G
F
M
-
S
I
M
T
M
A
M
I
S
I
D
------------
R
Y
N
V
I
G
R
P
M
A
-
A
----
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
--
V
W
L
W
S
V
L
W
A
I
G
P
----------------
I
F
G
W
G
-------
A
----
Y
T
L
E
G
V
L
C
N
C
---------------------------
S
F
D
Y
I
-
S
--
R
--------------------
D
S
--
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
----------
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
A
K
I
S
I
V
I
--------
V
S
Q
F
L
-
L
S
W
S
----
P
Y
-
A
V
V
A
L
L
A
Q
-
F
G
------------
P
LEW-
V
------------
T
P
Y
A
A
Q
L
P
V
M
-
F
-
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
------------------------------------------------------------------------------
28
HHSearch
86.31
16%
-145
- C4 -
3EML
13
ENLYS_BPT4
A:
[21-469]
---------------------------------------------------------
S
S
V
----------------
Y
I
T
V
E
L
---------------
A
I
A
V
L
A
I
L
G
-
N
V
L
V
C
W
A
V
W
L
N
-
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
--
D
I
A
V
G
V
L
A
-
I
P
---
F
A
I
T
-
I
S
--------
T
---
G
F
C
---
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
---
L
T
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
------------
R
Y
I
A
I
R
I
P
L
R
-
Y
----
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
--
C
W
V
L
S
F
A
I
G
L
T
P
----------------
M
L
G
W
N
-------
N
C
G
Q
-------
S
Q
G
C
---------------------------
G
E
G
Q
V
------
A
C
--------
L
-------
F
E
D
VV
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
----------
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
L
A
I
I
--------
V
G
L
F
A
-
L
C
W
L
----
P
L
-
H
I
I
N
C
F
T
F
-
F
C
------------
P
DCSH
A
------------
P
L
W
L
M
Y
L
A
I
V
-
L
-
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------------------------------------------------------------------------
26
HHSearch
85.53
17%
-144
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
---------------------------------------------------------
V
V
G
----------------
M
G
I
V
M
S
---------------
L
I
V
L
A
I
V
F
G
-
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
--
D
L
V
M
G
L
A
V
-
V
P
---
F
G
A
A
-
H
I
--------
L
-
M
K
M
W
T
---
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
---
C
V
T
A
-
S
I
E
T
L
C
V
I
A
V
D
------------
R
Y
F
A
I
T
S
P
F
K
-
Y
----
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
--
V
W
I
V
S
G
L
T
S
F
L
P
----------------
I
Q
M
H
W
-------
Y
-
R
A
---
T
H
Q
E
A
I
N
C
---------------------------
Y
A
E
-------
E
T
C
--------
C
-------
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
----------
E
A
K
R
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
H
K
A
L
K
T
L
G
I
I
--------
M
G
T
F
T
-
L
C
W
L
----
P
F
-
F
I
V
N
I
V
H
V
-
I
Q
------------
D
NL--
I
------------
R
K
E
V
Y
I
L
L
N
W
-
I
-
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------
30
HHSearch
85.14
18%
-147
- C4 -
2KS9
1
NK1R_HUMAN
A:
[33-324]
----------------------------------------------------------
V
L
----------------
W
A
A
A
Y
T
---------------
V
I
V
V
T
S
V
V
G
-
N
V
V
V
M
W
I
I
L
A
H
-
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
--
E
A
S
M
A
A
F
N
-
T
V
---
V
N
F
T
-
Y
A
--------
V
-
H
N
E
W
Y
---
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
---
A
V
F
A
-
S
I
Y
S
M
T
A
V
A
F
D
------------
R
Y
M
A
I
I
H
P
L
Q
-
P
----
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
--
I
W
V
L
A
L
L
L
A
F
P
Q
----------------
G
Y
Y
S
T
-------
T
-----
E
T
M
P
S
R
V
V
C
---------------------------
M
I
E
W
P
-
E
--
H
P
------------------
N
K
I
--
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
----------
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
V
K
M
M
I
V
V
--------
V
C
T
F
A
-
I
C
W
L
----
P
F
-
H
I
F
F
L
L
P
Y
-
I
N
------------
P
----
D
LYLKKF------
I
Q
Q
V
Y
L
A
I
M
W
-
L
-
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
------------------------------------------------------------------------------
22
HHSearch
83.22
19%
-146
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
----------------------------------------------------------
V
F
----------------
I
V
L
V
A
G
---------------
S
L
S
L
V
T
I
I
G
-
N
I
L
V
M
V
S
I
K
V
N
-
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
--
D
L
I
I
G
V
F
S
-
M
N
---
L
Y
T
L
-
Y
T
--------
V
-
I
G
Y
W
P
---
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
---
V
S
N
A
-
S
V
M
N
L
L
I
I
S
F
D
------------
R
Y
F
C
V
T
K
P
L
T
-
Y
----
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
--
A
W
V
L
S
F
I
L
W
A
P
A
----------------
I
L
F
W
Q
-------
F
I
--
V
G
V
R
T
V
E
D
G
E
C
---------------------------
Y
I
Q
F
F
-----------------------------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
----------
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
K
V
T
R
T
I
L
A
I
--------
L
L
A
F
I
-
I
T
W
A
----
P
Y
-
N
V
M
V
L
I
N
T
-
F
C
------------
A
PC--
I
------------
P
N
T
V
W
T
I
G
Y
W
-
L
-
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----------------------------------------------------------------------------------
42
Fugue
78.76
16%
-132
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
----------------------------
M
-
N
--------
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
FEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
---------------
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
--
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
-
T
S
--------
L
-
H
G
Y
F
V
---
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
---
G
G
E
I
-
A
L
W
S
L
V
V
L
A
I
E
------------
R
Y
V
V
V
C
K
P
M
--
S
----
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
--
T
W
V
M
A
L
A
C
A
A
P
P
----------------
L
V
G
W
S
------------------
R
Y
I
P
---------------------------
E
---
G
-
M
--
Q
C
S
C
--------
G
I
DYYTPH
E
E
T
--
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
----------
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
-
P
Y
A
G
----
V
A
-
F
Y
I
F
T
H
Q
G
-
S
D
------------
F
----
G
------------
P
I
F
M
T
I
P
A
F
F
-
A
-
K
T
S
A
V
-
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
STTVSKTETS
Q
V
A
P
A---------------------------------------------------------------
33
HHSearch
78.37
18%
-145
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------------------------------------------
Y
A
L
S
Y
C
---------------
A
L
I
L
A
I
V
F
G
-
N
G
L
V
C
M
A
V
L
K
E
-
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
--
D
L
L
V
A
T
L
V
-
M
P
---
W
V
V
Y
-
L
E
--------
V
T
G
G
V
W
N
---
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
---
M
C
T
A
-
S
I
W
N
L
C
A
I
S
I
D
------------
R
Y
T
A
V
V
M
P
V
H
-
Y
----
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
--
V
W
V
L
A
F
A
V
S
C
P
L
----------------
L
F
G
F
N
-------
T
-------
T
G
D
P
T
V
C
---------------------------
S
I
S
N
------------------------------
P
D
--
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
----------
V
L
K
Q
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
T
Q
M
V
A
I
V
--------
L
G
A
F
I
-
V
C
W
L
----
P
F
-
F
L
T
H
V
L
N
T
-
H
C
------------
Q
TCH-
V
------------
S
P
E
L
Y
S
A
T
T
W
-
L
-
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
----------------------------------------------------------------------------------
45
Fugue
74.49
14%
-113
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----------------------------
M
-
N
--------
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
FEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
---------------
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
--
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
-
T
S
--------
L
-
H
G
Y
F
V
---
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
---
G
G
E
I
-
A
L
W
S
L
V
V
L
A
I
E
------------
R
Y
V
V
V
C
K
P
M
S
N
F
----
R
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
--
V
M
A
L
A
C
A
A
P
P
L
V
----------------
G
------------------------
W
S
---------------------------
R
Y
I
P
E
G
M
--
Q
C
S
C
G
I
DYYTPH
E
-------
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
VKEAAAQQQE
S
A
T
T
Q
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
T
R
M
V
I
I
M
V
I
A
--------
F
L
I
C
W
-
L
P
Y
A
----
G
V
-
A
F
Y
I
F
T
H
Q
-
G
S
------------
D
----
F
------------
G
P
I
F
M
T
I
P
A
F
-
F
-
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
LGDDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------
32
HHSearch
71.26
14%
-141
- C4 -
3V2Y
1
ENLYS_BPT4
A:
[61-495]
-------------------------------------------------------
N
S
I
K
L
----------------
T
S
V
V
F
I
---------------
L
I
C
C
F
I
I
L
E
-
N
I
F
V
L
L
T
I
W
K
T
-
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
--
D
L
L
A
G
V
A
Y
-
T
A
---
N
L
L
L
-
S
G
--------
A
--
T
T
Y
K
---
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
---
A
L
S
A
-
S
V
F
S
L
L
A
I
A
I
E
------------
R
Y
I
T
M
L
K
----------------
N
N
F
R
L
F
L
L
I
S
A
--
C
W
V
I
S
L
I
L
G
G
L
P
----------------
I
M
G
W
N
-------
C
-------
I
S
A
L
S
S
C
---------------------------
S
T
V
L
P
-
L
---------------------------
Y
H
K
H
Y
-
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
----------
L
V
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
A
L
L
K
T
V
I
I
V
--------
L
S
V
F
I
-
A
C
W
A
----
P
L
-
F
I
L
L
L
L
D
V
-
G
C
------------
K
----
V
KTC
D
--------
I
L
F
R
A
E
Y
F
L
V
-
L
-
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
--------------------------------------------------------------------------------
23
HHSearch
70.91
17%
-144
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-496]
-------------------------------------------------------
F
N
K
I
F
----------------
L
P
T
I
Y
S
---------------
I
I
F
L
T
G
I
V
G
-
N
G
L
V
I
L
V
M
G
Y
Q
-
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
--
D
L
L
F
V
-
I
T
-
L
P
---
F
W
A
V
-
D
A
--------
V
--
A
N
W
Y
---
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
---
N
L
Y
S
-
S
V
W
I
L
A
F
I
S
L
D
------------
R
Y
L
A
I
V
H
A
T
N
-
S
----
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
--
V
W
I
P
A
L
L
L
T
I
P
D
----------------
F
I
F
A
N
-------
V
-----
S
E
A
D
D
R
Y
I
C
---------------------------
D
R
F
Y
P
-
N
-----------------------
D
L
--
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
----------
K
L
S
H
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
--------
I
L
A
F
F
-
A
C
W
L
----
P
Y
-
Y
I
G
I
S
I
D
S
-
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
----
T
------------
V
H
K
W
I
S
I
T
E
A
-
L
-
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
------------------------------------------------------------------------------
31
HHSearch
68.99
14%
-114
- C4 -
1U19
14
OPSD_BOVIN
A:
[40-327]
---------------------------------------------------------
F
S
M
----------------
L
A
A
Y
M
F
---------------
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
--
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
-
T
S
--------
L
-
H
G
Y
F
V
---
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
---
G
G
E
I
-
A
L
W
S
L
V
V
L
A
I
E
------------
R
Y
V
V
V
C
K
P
M
S
-
N
----
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
--
T
W
V
M
A
L
A
C
A
A
P
P
----------------
L
V
G
W
S
-------
R
--
Y
--
I
P
E
G
M
Q
C
S
C
---------------------------
G
I
D
Y
Y
-
T
--
P
H
------------------
E
E
T
--
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
----------
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
V
I
I
M
--------
V
I
A
F
L
-
I
C
W
L
----
P
Y
-
A
G
V
A
F
Y
I
F
-
T
H
QGS---------
D
----
F
------------
G
P
I
F
M
T
I
P
A
F
-
F
-
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
------------------------------------------------------------------------------
34
HHSearch
65.17
13%
-126
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
-------------------------------------------------------
L
N
K
Y
V
----------------
V
I
I
A
Y
A
---------------
L
V
F
L
L
S
L
L
G
-
N
S
L
V
M
L
V
I
L
Y
S
-
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
--
D
L
L
F
A
L
T
--
L
P
---
I
W
A
A
-
S
K
----------
V
N
G
W
I
---
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
---
N
F
Y
S
-
G
I
L
L
L
A
C
I
S
V
D
------------
R
Y
L
A
I
V
H
A
T
R
-
T
----
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
--
C
W
G
L
S
M
N
L
S
L
P
F
----------------
F
L
F
R
Q
-------
A
--
Y
--
H
P
N
N
S
S
P
V
C
---------------------------
Y
E
V
L
G
-
N
--
D
-------------------
T
A
K
--
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
----------
T
L
F
K
A
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
M
R
V
I
F
A
V
--------
V
L
I
F
L
-
L
C
W
L
----
P
Y
-
N
L
V
L
L
A
D
T
-
L
M
------------
R
----
T
QVIQE
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
E
I
-
L
-
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
--------------------------------------------------------------------------------
19
PsiBlast_PDB
57.29
25%
-182
- C4 -
4EIY
18
AA2AR_HUMAN (first)
A:
[39-158]
---------------------------------------------------------------------------------
L
---------------
A
I
A
V
L
A
I
L
G
-
N
V
L
V
C
W
A
V
W
L
N
-
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
--
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
-
G
F
--------
C
-
A
A
C
H
G
---
C
L
F
I
A
C
-----
F
V
L
V
---
L
T
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
------------
R
Y
I
A
I
R
I
P
L
R
-
Y
----
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
--
C
W
V
L
S
F
A
I
G
L
T
P
----------------
M
L
G
W
N
-------
N
C
G
Q
P
K
E
G
K
N
H
S
Q
G
C
---------------------------
G
E
G
Q
V
-
A
--
C
L
F
E
--------
D
-------
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
----------
A
R
R
Q
L
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
N
W
E
T
L
N
D
N
L
K
V
--------
I
E
K
A
D
-
N
A
A
Q
----
V
K
-
D
A
L
T
K
M
R
A
-
A
A
------------
L
----
D
------------
A
Q
K
M
K
D
F
R
H
G
-
F
-
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
------------------------------------------------------------------------------
50
Fugue
56.17
10%
-140
- C2 -
2CE7
1
FTSH_THEMA
A:
[5-457]
-------------------------
Y
K
P
S
-
G
--------
N
K
R
V
T
F
K
D
V
G
G
-
A
E
E
A
I
E
E
L
K
----------------
E
V
V
E
F
L
K
D
P
S
K
F
N
R
I
GARMPK
G
I
L
L
V
G
P
P
G
-
T
G
K
T
L
L
A
R
A
V
A
-
G
E
A
N
V
P
-
F
F
H
I
S
G
S
D
F
V
--
E
L
F
V
G
------------------------
V
-
G
A
A
R
V
---
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
---
F
I
D
---
E
I
D
A
V
G
R
H
D
E
------------
R
E
Q
T
L
N
Q
L
L
V
-
E
----
M
D
G
---
F
D
S
K
E
G
I
I
V
M
A
A
--
T
N
R
P
D
I
L
D
P
A
L
L
RPGRFD
K
K
I
V
V
D
PPD
M
L
G
R
K
K
-------
I
L
E
I
H
T
R
N
K
P
L
A
E
D
V
---------------------------
N
L
E
I
I
-
A
K
R
T
P
G
F
--------
V
-------
G
A
D
--
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
----------
R
V
I
L
I
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
R
I
I
A
Y
H
E
A
G
H
A
--------
V
V
S
T
V
-
V
P
N
G
----
E
P
-
V
H
R
I
S
I
I
K
-
Y
L
------------
V
----
S
-------------
R
N
E
L
L
D
K
L
T
-
A
-
L
L
G
G
R
A
A
E
E
V
V
F
G
D
V
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
CQLGMSEELGPLAWGKLRNYS
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
KETIE
G
D
E
L
R
R
I
L
S
43
Fugue
55.61
21%
-85
- C4 -
4OWT
-
INT3_HUMAN
A:
[1-466]
GGRL
L
L
S
T
SLDAKD
E
L
E
E
R
L
E
R
C
M
S
I
V
T
S
M
T
AGVS
E
R
E
A
N
D
A
L
N
A
Y
V
C
K
G
L
P
Q
H
E
E
I
C
L
G
----------------
L
F
T
L
I
L
T
E
PAQ
A
Q
K
C
Y
R
----
D
L
A
L
V
S
R
D
G
M
N
I
V
L
N
K
I
N
Q
I
L
M
E
K
Y
L
K
L
Q
D
T
C
R
T
Q
L
V
W
L
V
R
E
L
V
K
S
G
V
L
-
G
A
---
D
G
V
C
M
T
F
M
K
Q
IAGGD
V
-
T
A
K
N
I
W
L
A
E
S
V
L
D
I
L
T
E
Q
R
E
W
V
L
K
S
S
I
L
I
A
M
A
V
Y
T
Y
L
R
L
I
V
D
HHGT
A
Q
L
Q
A
L
R
Q
K
E
V
D
F
C
I
S
L
L
-
R
E
R
F
M
E
C
L
M--
I
G
R
D
L
V
R
L
L
Q
N
V
AR
I
P
E
F
E
L
L
W
K
D
I
I
----------------
H
N
P
Q
A
LSPQFTG
I
L
Q
L
L
Q
S
R
T
S
R
K
F
L
A
C
R
L
T
P
D
M
E
T
K
L
L
F
M
T
S
RVRFGQQ
K
R
Y
Q
D
W
F
Q
R
-
Q
--
Y
L
S
T
PD------
S
-------
Q
S
L
--
R
C
D
L
I
R
Y
I
C
G
V
V
H
P
---
S
N
E
V
L
S
S
D
I
L
P
R
W
----------
A
I
I
G
W
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
C
T
S
N
V
A
A
S
N
A
K
L
--------
A
L
F
Y
D
W
L
F
F
S
PDKD
S
I
M
N
I
E
P
A
I
L
V
M
H
H
------------
S
M---
K
------------
P
H
P
A
I
T
A
T
L
L
D
F
M
C
R
I
I
P
N
F
Y
P
P
L
E
G
H
V
R
Q
G
V
F
S
S
L
N
H
I
V
E
K
R
V
L
A
HL
A
P
L
F
D
NPKLD
K
E
L
R
A
M
L
R
E
K
FPEFCS--------------------------------------------------
15
PsiBlast_PDB
55.40
25%
-178
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[14-133]
---------------------------------------------------------------------------------
L
---------------
A
I
A
V
L
A
I
L
G
-
N
V
L
V
C
W
A
V
W
L
N
-
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
--
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
-
G
F
--------
C
-
A
A
C
H
G
---
C
L
F
I
A
C
-----
F
V
L
V
---
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
------------
R
Y
I
A
I
A
I
P
L
R
-
Y
----
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
--
C
W
V
L
S
F
A
I
G
L
T
P
----------------
M
L
G
W
N
-------
N
C
G
Q
P
G
C
G
E
G
Q
V
A
C
L
---------------------------
F
E
D
V
V
-
P
--
M
N
Y
M
--------
V
-------
Y
F
N
--
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
----------
E
S
Q
P
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
--------
K
S
A
A
I
-
I
A
G
L
----
F
A
-
L
C
W
L
P
L
H
I
-
I
N
------------
C
----
F
------------
T
F
F
C
P
D
C
S
H
A
-
P
-
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
------------------------------------------------------------------------------
14
PsiBlast_PDB
55.39
25%
-180
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[14-133]
---------------------------------------------------------------------------------
L
---------------
A
I
A
V
L
A
I
L
G
-
N
V
L
V
C
W
A
V
W
L
N
-
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
--
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
-
G
F
--------
C
-
A
A
C
H
G
---
C
L
F
I
A
C
-----
F
V
L
V
---
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
------------
R
Y
I
A
I
A
I
P
L
R
-
Y
----
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
--
C
W
V
L
S
F
A
I
G
L
T
P
----------------
M
L
G
W
N
-------
N
C
G
Q
P
G
C
G
E
G
Q
V
A
C
L
---------------------------
F
E
D
V
V
-
P
--
M
N
Y
M
--------
V
-------
Y
F
N
--
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
----------
E
S
Q
P
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
--------
K
S
A
A
I
-
I
A
G
L
----
F
A
-
L
C
W
L
P
L
H
I
-
I
N
------------
C
----
F
------------
T
F
F
C
P
D
C
S
H
A
-
P
-
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
------------------------------------------------------------------------------
16
PsiBlast_PDB
54.90
25%
-179
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[14-133]
---------------------------------------------------------------------------------
L
---------------
A
I
A
V
L
A
I
L
G
-
N
V
L
V
C
W
A
V
W
L
N
-
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
--
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
-
G
F
--------
C
-
A
A
C
H
G
---
C
L
F
I
A
C
-----
F
V
L
V
---
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
------------
R
Y
I
A
I
A
I
P
L
R
-
Y
----
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
--
C
W
V
L
S
F
A
I
G
L
T
P
----------------
M
L
G
W
N
-------
N
C
G
Q
P
G
C
G
E
G
Q
V
A
C
L
---------------------------
F
E
D
V
V
-
P
--
M
N
Y
M
--------
V
-------
Y
F
N
--
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
----------
E
S
Q
P
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
--------
K
S
A
A
I
-
I
A
G
L
----
F
A
-
L
C
W
L
P
L
H
I
-
I
N
------------
C
----
F
------------
T
F
F
C
P
D
C
S
H
A
-
P
-
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
------------------------------------------------------------------------------
13
PsiBlast_PDB
54.25
25%
-182
- C4 -
3REY
1
AA2AR_HUMAN
A:
[14-133]
---------------------------------------------------------------------------------
L
---------------
A
I
A
V
L
A
I
L
G
-
N
V
L
V
C
W
A
V
W
L
N
-
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
--
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
-
G
F
--------
C
-
A
A
C
H
G
---
C
L
F
I
A
C
-----
F
V
L
V
---
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
D
------------
R
Y
I
A
I
A
I
P
L
R
-
Y
----
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
--
C
W
V
L
S
F
A
I
G
L
T
P
----------------
M
L
G
W
N
-------
N
C
G
Q
P
G
C
G
E
G
Q
V
A
C
L
---------------------------
F
E
D
V
V
-
P
--
M
N
Y
M
--------
V
-------
Y
F
N
--
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
----------
E
S
Q
P
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
--------
K
S
A
A
I
-
I
A
G
L
----
F
A
-
L
C
W
L
P
L
H
I
-
I
N
------------
C
----
F
------------
T
F
F
C
P
D
C
S
H
A
-
P
-
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
------------------------------------------------------------------------------