Atome 2 Filter

Query sequence : OR8D4_HUMAN: (2016-01-14 )
MGVKNHSTVTEFLLSGLTEQAELQLPLFCLFLGIYTVTVVGNLSMISIIRLNRQLHTPMYYFLSSLSFLDFCYSSVITPKMLSGFLCRDRSISYSGCMIQLFFFCVCVISECYMLAAMACDRYVAICSPLLYRVIMSPRVCSLLVAAVFSVGFTDAVIHGGCILRLSFCGSNIIKHYFCDIVPLIKLSCSSTYIDELLIFVIGGFNMVATSLTIIISYAFILTSILRIHSKKGRCKAFSTCSSHLTAVLMFYGSLMSMYLKPASSSSLTQEKVSSVFYTTVILMLNPLIYSLRNNEVRNALMKLLRRKISLSPG

Atome Classification :

	(20 SA)									------------......-...10-------------......--...20..-------.---..---...30....------..-.----------------------.40...-..-...50........60----------------------.....----....70.-.....-..---80.....-...-------90........100..--.....110.-------......120......----.130..--------..---....--------------140-....---..----..150.......160.......170.......--180..-.....-------190-----....--.....--200..---.....210.......220-...----..-----------...-------.230----------.--------------------....-----------...240....------------.....250.---........260...----.-.----.-..270---..--------......280..-.....290-.......300...------------------....310..----------------------------------------------------------------------------------------------------------------------------------------------------------
		(Atome)	(Ident)	(Tito)	(Num)		(Ligand)	(Uniprot)		------------MGVKNH-STVT--------------EFLLSG--LTEQAEL-------Q---LP---LFCLFLGIY------TV-T----------------------VVGNLS-MI-SIIRLNRQLHTPMY-----------------------YFLSS----LSFLDFC-YSSVI-TP---KMLSGFL-CRD-------RSISYSGCMIQLFFF--CVCVISECY-------MLAAMACDRYVAICS----PLL-YR--------VI---MSPR--------------V-C-SLLV---AA----VFSVGFTDAVIHGGCILRLSFCGSNIIKHYFC--DIVPL-IKLSC-------S-------STYI--DELLI--FVIGG---FNMVATSLTIIISYAF---ILT----SI-----------LRI-------HSK-----------K--------------------GRCK-----------AFST--CSSH------------LTAVLM--F---YGSLMSMYL-KPAS----S-S----S-LTQ-E---KV--------SSVFYTTVILM-LNPLIYSL-RNNEVRNALMKLL------------------RRKISLSPG----------------------------------------------------------------------------------------------------------------------------------------------------------
33	HHSearch	88.85	17%	-152	- C1 -	2Z73		OPSD_TODPA	A:[35-336]	---------------------------------------------------------------YS---LGIFIGICG------II-G----------------------CGGNGI-VI-YLFTKTKSLQTPAN-----------------------MFIIN----LAFSDFT-FSLVNGFP---LMTISCF-LKK-------WIFGFAACKVYGFIG--GIFGFMSIM-------TMAMISIDRYNVIGR----PMA-AS--------KK---MSHR--------------R-A-FIMI---IF----VWLWSVLWAIGPIFGWGA---YTL-EGVLCNC--SFDYI-S-------------------RDST--TRSNI--LCMFI---LGFFGPILIIFFCYFN---IVM----SV-----------SNH-------EKE-----------MAAMAKRLNAKELRKAQAGANAEMR-----------LAKI--SIVI------------VSQFLL--S---WSPYAVVAL-LAQF----G-PLEW-V-TPY-A---AQ--------LPVMFAKASAI-HNPMIYSV-SHPKFREAISQTF------------------PWVLTCCQF----------------------------------------------------------------------------------------------------------------------------------------------------------
30	HHSearch	86.85	18%	-147	- C1 -	2KS9		NK1R_HUMAN	A:[35-324]	--------------------------------------------------------------------WAAAYTVIV------VT-S----------------------VVGNVV-VM-WIILAHKRMRTVTN-----------------------YFLVN----LAFAEAS-MAAFN-TV---VNFTYAV-HNE-------WYYGLFYCKFHNFFP--IAAVFASIY-------SMTAVAFDRYMAIIH----PLQ-PR--------L-----SAT--------------A-T-KVVI---CV----IWVLALLLAFPQGYYSTT----E-TMPSRVVC--MIEWP-EHPNK-------I---------Y---EKVYH--ICVTV---LIYFLPLLVIGYAYTV---VGI----TL-----------WAS-------EIPGDSSDRYHEQVS--------------------AKRK-----------VVKM--MIVV------------VCTFAI--C---WLPFHIFFL-LPYI----N-PDLY-L-KKF-IQQVYL--------AIMWLAMSSTM-YNPIIYCC-LNDRFRLGFKHAF------------------RCCPFISAG----------------------------------------------------------------------------------------------------------------------------------------------------------
39	Fugue	85.83	16%	-135	- C1 -	1F88		OPSD_BOVIN	A:[1-348]	------------MNGTEG-PNFYVPFSNKTGVVRSPFEAPQYY--LAEPWQF-------S---ML---AAYMFLLIM------LG-F----------------------PINFLT-LY-VTVQHKK-LRTPLN-----------------------YILLN----LAVADLF-MVFGG-FT---TTLYTSL-HGY-------FVFGPTGCNLEGFFA--TLGGEIALW-------SLVVLAIERYVVVCK----PMSNFR--------FG---ENHA--------------I-M-GVAF---TW----VMALACAAPPLVG-----------------WS--RYIPEGMQCSC-------GIDYYTPHEETN--NESFV--IYMFV---VHFIIPLIVIFFCYGQ---LVF----TV-----------KEAAASATTQKAE-----------K--------------------EVTR-----------MVII--MVIA------------FLICWL--P---YAGVAFYIF-THQG----S-D----F-GPI-F---MT--------IPAFFAKTSAV-YNPVIYIM-MNKQFRNCMVTTLCCGKNPSTTVSK------TETSQVAPA----------------------------------------------------------------------------------------------------------------------------------------------------------
40	Fugue	79.83	16%	-122	- C1 -	1U19		OPSD_BOVIN	A:[4-349]	MNGTEGPNFYVPFSNKTG-VVRS--------------PFEAPQYYLAEPWQF-------S---ML---AAYMFL-LI------ML-G----------------------FPINFL-TL-YVTVQHKKLRTPLN-----------------------YILLN----LAVADLF-MVFGG-FT---TTLYTSL-HGY-------FVFGPTGCNLEGFFA--TLGGEIALW-------SLVVLAIERYVVVCK----PM-----------------------------------------------S----NFRFGENHAIMGVAFTWVMALACAAPPLVGWS--RYIPEGMQCSCGIDYYTPH-------EETN--NESFV--IYMFV---VHFIIPLIVIFFCYGQ---LVF----TVKEAAAQQQESATTQ-------KAE-----------K--------------------EVTR-----------MVII--MVIA------------FLICWL--P---YAGVAFYIF-THQG----S-D----F-GPI-F---MT--------IPAFFAKTSAV-YNPVIYIM-MNKQFRNCMVTTLCCGKNPLGDDEASTTVSKTETSQVAPA----------------------------------------------------------------------------------------------------------------------------------------------------------
43	Fugue	76.36	14%	-139	- C1 -	2RH1		ADRB2_HUMAN (first)	A:[36-477]	------------------------------------------------DEVW-------V---VG---MGIVMSLIV------LA-I----------------------VFGNVL-VI-TAIAKFERLQTVTN-----------------------YFITS----LACADLV-MGLAV-VP---FGAAHIL-MKM-------WTFGNFWCEFWTSID--VLCVTASIE-------TLCVIAVDRYFAITS----PFK-YQ--------SL---LTKN--------------K-A-RVII---LM----VWIVSG--LTSFLPIQMHWYRATHQEAINCYA--E------ETCC-------D-------FFTN--QAYAI--ASSIV---SFYVPLVIMVFVYSRV---FQE----AK-----------RQL-------NIF-----------E--------------------MLRI-----------DEGL--RLKI------------YKDTEG--Y---YTIGIGHLL-TKSP----S-L----N-AAK-S---EL--------DKAIGRNTNGV-ITKDEAEK-LFNQDVDAAVRGI------------------LRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL
28	HHSearch	75.44	16%	-133	- C1 -	1U19		OPSD_BOVIN	A:[41-327]	---------------------------------------------------------------SM---LAAYMFLLI------ML-G----------------------FPINFL-TL-YVTVQHKKLRTPLN-----------------------YILLN----LAVADLF-MVFGG-FT---TTLYTSL-HGY-------FVFGPTGCNLEGFFA--TLGGEIALW-------SLVVLAIERYVVVCK----PMS-NF--------R----FGEN--------------H-A-IMGV---AF----TWVMALACAAPPLVGWSR--Y-IPE-GMQCSC--GIDYY-TPHE----------------ETNN--ESFVI--YMF-V---VHFIIPLIVIFFCYGQ---LVF----TV-----------KEA-------AAQ-----------QQESATTQK------------AEKE-----------VTRM--VIIM------------VIAFLI--C---WLPYAGVAF-YIFTHQ--G-S----DFGPI-F---MT--------IPAFFAKTSAV-YNPVIYIM-MNKQFRNCMVTTL------------------CCGKNPLGD----------------------------------------------------------------------------------------------------------------------------------------------------------
47	Fugue	73.69	21%	-164	* C2 *	3GRE	-	VPS15_YEAST	A:[1031-1454]	--------------ESIE-KFLS--------------TFILPP--LRDYKEFGPIQEIVR---SP---NMGNLRGKL------IA-TLMENEPNSITSSAVSPGETPYLITGSDQGVI-KIWNLKEIIVGEVYSSSLTYDCSSTVTQITMIPNFDAFAVSSKDGQIIVLKVNHYQQES-EV---KFLNCEC-IRK-------INLKNFGKNEYAVRM--RAFVNEEKS-------LLVALTNLSRVIIFDIRTLERL-QI--------IE---NSPRHGA-----------V-S-SICIDEECC----VLILGTTRGIIDIWDI------RFNVLIRSWSFGDHAPI-THVEV-------C-------QFYG--KNSVI--VVGGSSKTFLTIWNFVKGHCQYAF---INSDEQPSM-----------EHF-------LPI-----------E--------------------KGLEELNFCGIRSLNALST--ISVS------------NDKILL--TDEATSSIVMFSL-NELS----S-S----K-AVI-S---PF--------SDVFIPTQVTANLTMLLRKM-KHDIINSISTCEV------------------DETPLLVACDNSGLIGIFQ------------------------------------------------------------------------------------------------------------------------------------------------
27	HHSearch	70.58	14%	-136	- C1 -	2LNL	-	CXCR1_HUMAN	A:[37-323]	--------------------------------------------------LN-------K---YV---VIIAYALVF------LL-S----------------------LLGNSL-VM-LVILYSRVGRSVTD-----------------------VYLLN----LALADLL-FAL-T-LP---IWAASKV--NG-------WIFGTFLCKVVSLLK--EVNFYSGIL-------LLACISVDRYLAIVH----ATR-TL--------T----QKRH--------------L-V-KFVC---LG----CWGLSMNLSLPFFLFRQA---YHPN-NSSPVC--YEVLG-N---D-------T-------AKW---RMVLR--ILPHT---FGFIVPLFVMLFCYGF---TLR----TL-----------FKA-------H-M-----------G--------------------QKHR-----------AMRV--IFAV------------VLIFLL--C---WLPYNLVLL-ADTLMRTQVIQESCER-RNNIGRA-LD--------ATEILGFLHSC-LNPIIYAF-IGQNFRHGFLKIL------------------AMHG---------------------------------------------------------------------------------------------------------------------------------------------------------------
48	Fugue	67.17	19%	-151	- C2 -	4QT9		?	A:[19-432]	------------LSDDALMDTVQ--------------RRTFLY--FWEGAEP-------NSGLAP---ERYHVDGVYPQNDANVV-T----------------------SGGSGF-GIMAILAGIDRGYVTRE-----------------------EGLARM---ERIVSFL-EKADR-FH---GAYPHWW-YGDTGKVKPFGQKDNGGDLVETAFLMQGLLAVHQYYANGNDKEKAIAQRIDRLWREVD----WDW-YRKGGQNVLYWH---WSPTYGWEMDFPIHGYNECMIMYILA---AA----SPTHGVPAAVYHDGWAQ-----NGAIVSPHKV--EGIEL--HLRY-------Q-------GTEA--GPLFWAQYSFLG---LDPVGLKDEYCPSYFHEMRNLT----LV-----------NRA-------YCI-----------RNPKHYKGFGPDCW-------GLTA-----------SYSVDGYAAHSPNEQDDKGVISPTAALSSIV---YTPEYSLQVMRHLY----NMG----D-KVF-G---PFGFYDAFSETDNWYPQRYLA-IDQGPIAVMIENYRTGLLWKLFMSHPDVQAG---------LTKLGFNTN----------------------------------------------------------------------------------------------------------------------------------------------------------
19	PsiBlast_PDB	65.38	25%	-173	- C1 -	3QAK		ENLYS_BPT4	A:[29-189]	-------------------------------------------------------------------------LAIA------VL-A----------------------ILGNVL-VC-WAVWLNSNLQNVTN-----------------------YFVVS----LAAADIA-VGVLA-IPFAITISTGFC-A------------ACHGCLFIACFV--LVLTQSSIF-------SLLAIAIDRYIAIRI----PLR-YN--------GL---VTGT--------------R-A-KGII---AICWVLSFAIGLTPMLGWNNCG---QGCGEGQVACLFE--DVVPM-NYMVY-------F-------NFFA--CVLVP--LLLML---GVYLRIFLAARRQLNI---FEM----LR-----------IDE-------GLR-----------L--------------------KIYK-----------DTEG--YYTI------------GIGHLL--T---KSPSLNAAK-SELD----K-A----I-GRN-T---NG--------VITKDEAEKLF-NQDVDAAV-RGILRNAKLKPVY------------------DSLDAVRRA----------------------------------------------------------------------------------------------------------------------------------------------------------
24	HHSearch	65.30	19%	-176	- C1 -	3EML		ENLYS_BPT4	A:[22-221]	---------------------------------------------------------------SV---YITVELAIA------VL-A----------------------ILGNVL-VC-WAVWLNSNLQNVTN-----------------------YFVVS----LAAADIA-VGVLA-IP---FAITIST---G-------FCAACHGCLFIACFV--LVLTQSSIF-------SLLAIAIDRYIAIRI----PLR-YN--------GL---VTGT--------------R-A-KGII---AI----CWVLSFAIGLTPMLGWNNCGQ-------SQGC--GEGQ----VAC-------L-------FEDVVPMNYMV--YFNFF---ACVLVPLLLMLGVYLR---IFL----AA-----------RRQ-------LNI-----------F--------------------EMLR-----------IDEG--LRLK------------IYKDTE--G---YYTIGIGHL-LTKS----P-S----L-NAA-K---SE--------LDKAIGRNTNG-VITKDEAE-KLFNQDVDAAVRG------------------ILRNAKLKP----------------------------------------------------------------------------------------------------------------------------------------------------------
18	PsiBlast_PDB	65.28	25%	-179	- C1 -	3EML		ENLYS_BPT4	A:[29-189]	-------------------------------------------------------------------------LAIA------VL-A----------------------ILGNVL-VC-WAVWLNSNLQNVTN-----------------------YFVVS----LAAADIA-VGVLA-IPFAITISTGFC-A------------ACHGCLFIACFV--LVLTQSSIF-------SLLAIAIDRYIAIRI----PLR-YN--------GL---VTGT--------------R-A-KGII---AICWVLSFAIGLTPMLGWNNCGQ-SQGCGEGQVACLFE--DVVPM-NYMVY-------F-------NFFA--CVLVP--LLLML---GVYLRIFLAARRQLNI---FEM----LR-----------IDE-------GLR-----------L--------------------KIYK-----------DTEG--YYTI------------GIGHLL--T---KSPSLNAAK-SELD----K-A----I-GRN-T---NG--------VITKDEAEKLF-NQDVDAAV-RGILRNAKLKPVY------------------DSLDAVRRA----------------------------------------------------------------------------------------------------------------------------------------------------------
23	HHSearch	63.74	17%	-151	- C1 -	2RH1		ADRB2_HUMAN (first)	A:[40-235]	-----------------------------------------------------------V---VG---MGIVMSLIV------LA-I----------------------VFGNVL-VI-TAIAKFERLQTVTN-----------------------YFITS----LACADLV-MGLAV-VP---FGAAHIL-MKM-------WTFGNFWCEFWTSID--VLCVTASIE-------TLCVIAVDRYFAITS----PFK-YQ--------SL---LTKN--------------K-A-RVII---LM----VWIVSGLTSFLPIQMHWY-RATHQ---EAINC--YAE-----ETC-------C-------DFFT--NQAYA--IASSI---VSFYVPLVIMVFVYSR---VFQ----EA-----------KRQ-------LNI-----------F--------------------EMLR-----------IDEG--LRLK------------IYKDTE--G---YYTIGIGHL-LTKS----P-S----L-NAA-K---SE--------LDKAIGRNTNG-VITKDEAE-KLFNQDVDAAVRG------------------ILRNAKLKP----------------------------------------------------------------------------------------------------------------------------------------------------------
22	HHSearch	62.83	21%	-162	- C1 -	3RZE		ENLYS_BPT4 (first)	A:[10-200]	----------------------------------------------------------------P---LVVVLSTIC------LV-T----------------------VGLNLL-VL-YAVRSERKLHTVGN-----------------------LYIVS----LSVADLI-VGAVV-MP---MNILYLL-MSK-------WSLGRPLCLFWLSMD--YVASTASIF-------SVFILCIDRYRSVQQ----PLR-YL--------KY---RTKT--------------R-A-SATI---LG----AWFLSFLWVIPILGWN-H--------RREDKC--ETDFY-D---------------------V---TW-FK--VMTAI---INFYLPTLLMLWFYAK---IYK----AV-----------RQH-------CNI-----------F--------------------EMLR-----------IDEG--LRLK------------IYKDTE--G---YYTIGIGHL-LTKS----P-S----L-NAA-K---SE--------LDKAIGRNTNG-VITKDEAE-KLFNQDVDAAVRG------------------ILRNAKLKP----------------------------------------------------------------------------------------------------------------------------------------------------------
21	HHSearch	62.60	18%	-173	- C1 -	3UON		ACM2_HUMAN (first)	A:[25-215]	----------------------------------------------------------------F---IVLVAGSLS------LV-T----------------------IIGNIL-VM-VSIKVNRHLQTVNN-----------------------YFLFS----LACADLI-IGVFS-MN---LYTLYTV-IGY-------WPLGPVVCDLWLALD--YVVSNASVM-------NLLIISFDRYFCVTK----PLT-YP--------VK---RTTK--------------M-A-GMMI---AA----AWVLSFILWAPAILFWQF--IVGVRTVEDGEC--YIQFF------------------------S--NAAVT--FGTAI---AAFYLPVIIMTVLYWH---ISR----AS-----------KSR-------INI-----------F--------------------EMLR-----------IDEG--LRLK------------IYKDTE--G---YYTIGIGHL-LTKS----P-S----L-NAA-K---SE--------LDKAIGRNTNG-VITKDEAE-KLFNQDVDAAVRG------------------ILRNAKLKP----------------------------------------------------------------------------------------------------------------------------------------------------------
29	HHSearch	59.92	18%	-166	* C1 *	3PBL		DRD3_HUMAN (first)	A:[41-226]	--------------------------------------------------------------------YALSYCALI------LA-I----------------------VFGNGL-VC-MAVLKERALQTTTN-----------------------YLVVS----LAVADLL-VATLV-MP---WVVYLEVTGGV-------WNFSRICCDVFVTLD--VMMCTASIW-------NLCAISIDRYTAVVM----PVH-YQ--------HGTGQSSCR--------------R-V-ALMI---TA----VWVLAFAVSCPLLFGF-N--T----TGDPTVC--S-------------------------ISNP--D-FVI--YS-SV---VSFYLPFGVTVLVYAR---IYV----VL-----------KQR-------RRK-----------N--------------------IFEM-----------LRID--EGLR------------LKIYKD--T---EGYYTIGIG-HLLT----K-S----P-SLN-A---AK--------SELDKAIGRNT-NGVITKDE-AEKLFNQDVDAAV------------------RGILRNAKL----------------------------------------------------------------------------------------------------------------------------------------------------------
1	PsiBlast_PDB	58.08	25%	-162	- C1 -	4IAR		C562_ECOLX	A:[12-145]	------------------------------------------------QDSI-------S---LPWKVLLVMLLALI------TLAT----------------------TLSNAF-VI-ATVYRTRKLHTPAN-----------------------YLIAS----LAVTDLL-VSILV-MP---ISTMYTV-TGR-------WTLGQVVCDFWLSSD--ITCCTASIW-------HLCVIALDRYWAITD----AVE-YS--------AK---RTPK--------------R-A-AVMI---AL----VWVFSISISLPPFFWRQASECVVNTDHILYTV--YSTVG-AFYFP-------T-------LLLI--ALYGR--IYVEA---RSRIADLEDNWETLND---NLK----VI-----------EKA-------DNA-----------A--------------------QVKD-----------ALTK--MRAA------------ALDAQK--A---TPPKLEDKS-PDSP----E-M----K-DFR-H---GF--------DILVGQIDDAL-KLANEGKV-KEAQAAAEQLKTT------------------RNAYIQKYL----------------------------------------------------------------------------------------------------------------------------------------------------------
32	HHSearch	57.69	18%	-163	- C1 -	3V2Y		ENLYS_BPT4	A:[64-249]	---------------------------------------------------------------KL---TSVVFILIC------CF-I----------------------ILENIF-VL-LTIWKTKKFHRPMY-----------------------YFIGN----LALSDLL-AGVAY-TA---NLLLSGA--TT-------YKLTPAQWFLREGSM--FVALSASVF-------SLLAIAIERYITMLK------------------------NNF--------------R-L-FLLI---SA----CWVISLILGGLPIMGWNC-------ISALSSC--STVLP-L---------------------YH--KHYIL--FC--T---TVFTLLLLSIVILYCR---IYS----LV-----------RTR-------NIF-----------E--------------------MLRI-----------DEGL--RLKI------------YKDTEG--Y---YTIGIGHLL-TKSP----S-L----N-AAK-S---EL--------DKAIGRNTNGV-ITKDEAEK-LFNQDVDAAVRGI------------------LRNAKLKPV----------------------------------------------------------------------------------------------------------------------------------------------------------
11	PsiBlast_PDB	57.67	25%	-154	- C1 -	4LDE			A:[197-309]	-------------------------------------------------------------------------------------------------------------VFGNVL-VI-TAIAKFERLQTVTN-----------------------YFITS----LACADLV-MGLAV-VP---FGAAHIL-TKT-------WTFGNFWCEFWTSID--VLCVTASIE-------TLCVIAVDRYFAITS----PFK-YQ--------SL---LTKN--------------K-A-RVII---LM----VWIVSGLTSFLPIQMHWYRATHQEAINCYAEE--TCCDF-FTNQA-------Y-------AIAS--SIVSF--YVPLV---IMVFVYSRVFQEAKRQ---LQK----FA-----------LKE-------HKA-----------L--------------------KTLG-----------IIMG--TFTL------------CWLPFF--I---VNIVHVIQD-NLIR----K-E----V-YIL-L---NW--------IGYVNSGFNPL-IYCRSPDF-RIAFQELLCL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12	PsiBlast_PDB	57.56	25%	-158	- C1 -	4LDL		ADRB2_HUMAN	A:[197-309]	-------------------------------------------------------------------------------------------------------------VFGNVL-VI-TAIAKFERLQTVTN-----------------------YFITS----LACADLV-MGLAV-VP---FGAAHIL-TKT-------WTFGNFWCEFWTSID--VLCVTASIE-------TLCVIAVDRYFAITS----PFK-YQ--------SL---LTKN--------------K-A-RVII---LM----VWIVSGLTSFLPIQMHWYRATHQEAINCYAEE--TCCDF-FTNQA-------Y-------AIAS--SIVSF--YVPLV---IMVFVYSRVFQEAKRQ---LQK----FA-----------LKE-------HKA-----------L--------------------KTLG-----------IIMG--TFTL------------CWLPFF--I---VNIVHVIQD-NLIR----K-E----V-YIL-L---NW--------IGYVNSGFNPL-IYCRSPDF-RIAFQELLCL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------