@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PTH2R_HUMAN: (2016-01-14 )
MAGLGASLHVWGWLMLGSCLLARAQLDSDGTITIEEQIVLVLKAKVQCELNITAQLQEGEGNCFPEWDGLICWPRGTVGKISAVPCPPYIYDFNHKGVAFRHCNPNGTWDFMHSLNKTWANYSDCLRFLQPDISIGKQEFFERLYVMYTVGYSISFGSLAVAILIIGYFRRLHCTRNYIHMHLFVSFMLRATSIFVKDRVVHAHIGVKELESLIMQDDPQNSIEATSVDKSQYIGCKIAVVMFIYFLATNYYWILVEGLYLHNLIFVAFFSDTKYLWGFILIGWGFPAAFVAAWAVARATLADARCWELSAGDIKWIYQAPILAAIGLNFILFLNTVRVLATKIWETNAVGHDTRKQYRKLAKSTLVLVLVFGVHYIVFVCLPHSFTGLGWEIRMHCELFFNSFQGFFVSIIYCYCNGEVQAEVKKMWSRWNLSVDWKRTPPCGSRRCGSVLTTVTHSTSSQSQVAASTRMVLISGKAAKIASRQPDSHITLPGYVWSNSEQDCLPHSFHEETKEDSGRQGDDILMEKPSRPMESNPDTEGCQGETEDVL
Atome Classification :
(22 SA)
--------------.........10-........20........----30.---.......--40........50...-----.-....60-.-.......70.....---...80........90...---.--.-...100..--.....110.......120.......130......--.140.......150....-...160.......170.......-----180.......190......---.200.......210.......220.......230........240.......250.......260.......------270----.--..-.....280..-.....290----------------......-..-300-.---.--.......---310-.-------.-------.-----.-----.----....320.......330.......340.....--.-----------.350.......360.......370.......380..-.-.--.-.-----------.------390.......400......-.410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520....---...530.......540---........550
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MAGLGA
S
L
H
V
W
-
G
W
L
M
L
G
S
C
L
L
A
R
AQLDSD----
G
T
I
---
T
I
E
E
Q
I
V
--
L
V
L
K
A
K
V
Q
C
E
L
N
I
T
A
-----
Q
-
L
QEGEG-N-CFPEWD
G
L
I
CWPRG---TVGKISAVPCP
P
Y
I
Y
DFN---H--K-
G
V
A
F
R
HCN--PNG
T
W
D
F
M
H
S
L
N
K
T
WA
N
Y
S
D
C
L
R
F
LQPDISI
G
K
Q
--
E
F
F
E
R
L
Y
V
M
Y
TVGYSI
S
F
-
G
S
L
A
V
A
I
L
I
I
G
Y
F
R
R
L
H
C
T
R
N
Y
I
-----
H
M
H
L
F
V
S
F
M
L
R
A
T
S
I
F
V
KD---
R
V
V
HAHI
G
V
K
E
L
E
S
L
I
MQDDPQNSIEATSVDKS-QYI
G
C
K
I
A
V
V
M
F
I
Y
F
L
AT
N
Y
Y
W
I
L
VE
G
L
Y
L
H
N
L
I
F
V
A
F
------FS-----D--T
K
-
Y
L
W
G
F
I
L
I
GW-G
F
P
A
A
F
V
-----------------
A
A
W
A
V
A
-
R
A
-T---L---A--DA
R
C
W
EL---S---A-------G-------
D
-----
I
-----
K
----
W
I
YQA
P
I
L
A
A
I
G
L
N
F
I
L
F
L
N
T
V
R
V
L
A
T
K
IWET--N-----------AVG
H
D
T
R
K
Q
Y
R
K
L
A
K
S
T
L
V
L
V
L
V
F
G
V
H
Y
I
V
F
V
CLPH-S-F--T-G-----------L------
G
W
E
I
R
M
H
C
E
L
F
F
N
S
F
Q
G
F
F
-
V
S
I
I
Y
C
YCNG
E
V
Q
A
E
V
K
K
M
W
S
RWN
L
S
V
DWKRTPPCGSR
R
C
G
S
V
L
T
T
V
THSTSSQ
S
Q
VAA
S
T
R
M
V
L
ISGK
A
A
K
IASRQPDSHITL
P
G
Y
V
WSNSEQDCLPH
S
F
H
E
E
T
KEDSGRQGDDILM---EKPSRPMESNPDTEG----CQGETEDVL
1
PsiBlast_PDB
85.64
37%
-152
- C4 -
4L6R
1
C562_ECOLX (first)
A:
[111-394]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
E
V
Q
K
E
V
A
K
M
Y
S
S
F
Q
V
M
Y
T
V
G
Y
S
L
S
L
-
G
A
L
L
L
A
L
A
I
L
G
G
L
S
K
L
H
C
T
R
N
A
I
-----
H
A
N
L
F
A
S
F
V
L
K
A
S
S
V
L
V
I
D
---
G
L
L
R
T
------------------------
L
S
D
G
-
A
V
A
G
C
R
V
A
A
V
F
M
Q
Y
G
I
V
A
N
Y
C
W
L
L
V
E
G
L
Y
L
H
N
L
L
G
L
A
T
------
L
P
-----
E
--
R
S
-
F
F
S
L
Y
L
G
I
G
W
-
G
A
P
M
L
F
V
-----------------
V
P
W
A
V
V
-
K
C
-
L
---
F
---
E
--
N
V
Q
C
W
-----
T
---
S
-------
N
-------
D
-----
N
-----
M
GFW-
W
I
L
R
F
P
V
F
L
A
I
L
I
N
F
F
I
F
V
R
I
V
Q
L
L
V
A
K
L
R
A
R
--
Q
-----------
M
--
H
H
T
D
Y
K
F
R
-
L
A
K
S
T
L
T
L
I
P
L
L
G
V
H
E
V
V
F
A
F
V
T
D
-
E
-
H
--
A
Q
G
-----------
T
------
L
R
S
A
K
L
F
F
D
L
F
L
S
S
F
Q
G
L
L
-
V
A
V
L
Y
C
F
L
N
K
E
V
Q
S
E
L
R
R
R
W
H
R
W
R
L
G
K
V
L
W
E
E
R
N
-------------------------------------------------------------------------------------------------------------------
62
Fugue
82.84
17%
-93
- C3 -
2OCC
-
COX1_BOVIN
A:
[1-514]
MFINRWLFSTN
H
K
D
I
G
T
L
Y
L
L
F
G
A
W
A
G
M
V
G
T
A
L
S
L
L
I
R
A
E
L
G
Q
P
----
G
T
L
LGD
D
Q
I
Y
N
V
V
--
V
T
A
H
A
F
V
M
I
F
F
M
V
M
P
-----
I
-
M
I
G
G
F
G
-
N
W
L
V
P
L
M
I
G
A
P
D
M
A
F
P
---
R
M
N
N
M
S
F
W
L
L
P
P
S
F
L
L
L
L
---
A
--
S
-
S
M
V
E
-------
A
G
A
-------
G
T
G
W
T
V
Y
P
P
----
L
A
G
N
L
A
H
A
G
A
--
S
V
D
L
T
I
F
S
L
H
L
A
G
V
S
S
I
L
-
G
A
I
N
F
I
T
T
I
I
N
M
K
P
P
---
A
M
S
Q
Y
-----
Q
T
P
L
F
V
W
S
V
M
I
T
A
V
L
L
L
L
--------
S
L
P
V
L
A
A
G
I
T
M
L
L
T
D
R
N
L
N
T
---
T
F
F
D
P
A
-
G
G
G
D
P
I
L
Y
Q
H
L
F
W
F
F
G
H
P
E
V
Y
I
L
I
L
P
G
F
G
M
I
S
H
I
V
T
Y
Y
S
GKKEP
F
G
-----
Y
--
M
G
-
M
V
W
A
M
M
S
I
G
F
L
G
F
I
V
W
A
H
HMFTVGMD
V
D
T
R
A
Y
F
T
S
A
T
M
I
I
A
-
I
P
-
T
---
G
---
V
--
K
V
F
S
W
L
A
---
T
---
L
HG-----
G
-------
N
-----
I
-----
K
----
W
--
S
P
A
M
M
W
A
L
G
F
I
F
L
F
T
V
G
G
L
T
G
I
V
L
A
N
S
S
L
--
D
-----------
I
V
L
H
D
T
-----
Y
Y
V
V
A
H
F
H
Y
V
L
S
M
G
A
V
F
A
I
M
G
G
F
V
H
-
W
-
F
--
P
-
L
-----------
F
SGYTLN
D
T
W
A
K
I
H
F
A
I
M
F
V
G
V
N
M
T
F
-
F
P
Q
H
F
L
G
L
S
G
-------------------------
M
P
R
R
Y
S
D
Y
P
D
A
Y
T
M
W
N
T
I
S
S
M
G
S
F
I
S
L
T
A
V
M
L
M
V
F
I
I
W
E
A
F
A
S
K
R
E
V
L
---
T
V
D
L
T
T
T
N
L
E
W
L
N
G
C
---------------------
P
P
P
Y
H
T
F
E
E
P
T
Y
V
N
----
L
K
-------
61
Fugue
68.77
19%
-105
- C4 -
4K5Y
7
CRFR1_HUMAN (first)
A:
[13-423]
--------H
Y
H
V
A
A
I
I
N
Y
L
G
H
C
I
S
L
-
V
A
L
L
V
A
F
V
L
F
L
R
A
R
S
I
R
C
----
L
R
N
---
I
I
H
A
N
L
I
A
A
F
I
L
R
N
A
T
W
F
V
V
Q
L
T
M
-----
S
-
P
E
V
H
Q
S
-
N
-----------------------------
V
G
W
C
R
L
V
---
T
--
A
-
A
Y
N
Y
F
H
V
T
--
N
F
F
W
M
F
G
E
G
C
Y
L
H
T
A
I
V
L
T
N
I
F
E
M
L
R
I
D
E
G
L
-
R
L
--
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
S
V
A
K
S
E
L
D
K
A
I
G
R
N
S
N
G
V
IT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
S
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
--
W
Y
N
Q
T
P
N
R
A
K
R
V
I
A
T
F
R
------
T
G
TW
D
A
Y
D
--
R
L
-
R
A
W
M
F
I
C
I
G
W
-
G
V
P
F
P
I
I
-----------------
V
A
W
A
I
G
-
K
L
-
Y
---
Y
---
D
--
N
E
K
C
W
A
G
---
K
---
R
-------
P
-------
G
-----
V
YT---
D
----
Y
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
-----
R
-----------
A
S
T
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
F
-------
V
--
N
-
E
-----------
V
------
S
R
V
V
F
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
-
V
S
V
F
A
C
F
L
N
S
-------------------------------------------------------------------------------------------------------------------------------------------
64
Fugue
67.27
16%
-112
- C1 -
4CVH
3
ISPD_HUMAN
A:
[1-411]
--------------------
S
M
H
P
Q
-
A
---
V
A
A
V
L
P
A
G
P
T
P
K
Q
F
----
C
P
I
---
L
E
R
P
L
I
S
--
Y
T
L
Q
A
L
E
R
-------------------------------
V
C
W
I
K
D
I
V
V
A
V
T
G
E
N
M
E
V
M
K
S
I
I
Q
K
Y
Q
---
H
--
K
-
R
I
S
L
V
E
A
G
--
V
T
R
H
R
S
I
F
N
G
L
K
A
L
A
E
D
--------
Q
I
N
S
K
L
S
K
P
--
E
------------------------
V
V
I
I
-----
H
D
A
V
R
P
F
V
-----
E
E
G
V
L
L
K
V
V
T
A
A
K
E
H
----------
G
A
A
G
A
I
R
P
L
V
S
T
V
V
S
P
S
A
D
G
C
L
D
Y
S
L
E
R
A
R
-
H
R
A
S
E
M
P
Q
A
F
L
-------------------
F
D
V
I
Y
E
A
Y
------
Q
Q
-----
C
--
S
D
-
Y
D
L
E
F
----
G
-
T
E
C
L
Q
L
A
-----------------
L
K
Y
C
C
T
-
K
A
-
K
---
L
---
V
E
G
S
P
D
L
W
K
V
---
T
---
Y
-------
K
-------
R
-----
D
-----
L
----
Y
A
A
E
S
I
I
K
E
R
I
S
-------
Q
E
I
C
V
V
M
D
T
E
E
D
N
--
K
-----------
H
V
G
H
L
L
E
E
V
L
K
S
E
L
N
H
V
K
V
T
S
E
A
L
D
Q
C
Y
-
N
F
V
C
V
N
V
-
T
-
T
--
S
-
D
-----------
F
------
Q
E
T
Q
K
L
L
S
M
L
E
E
S
S
L
C
I
L
Y
P
V
V
V
V
S
V
H
F
L
------------------
D
F
K
L
V
P
P
----------------------
S
Q
K
M
E
N
L
M
Q
I
R
E
F
A
K
E
V
K
E
R
----
N
I
L
L
Y
G
L
L
I
S
Y
P
Q
D
--------
D
Q
K
L
Q
E
S
L
R
Q
G
A
I
I
I
A
---
S
L
I
K
E
------
R
N
S
G
----
L
I
G
Q
L
L
I
A
-
21
PsiBlast_CBE
64.19
34%
-102
- C4 -
4K5Y
2
CRFR1_HUMAN
C:
[284-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
M
F
I
C
I
G
W
-
G
V
P
F
P
I
I
-----------------
V
A
W
A
I
G
-
K
L
-
Y
---
Y
---
D
--
N
E
K
C
W
A
G
---
K
---
R
-------
P
-------
G
-----
V
YT---
D
----
Y
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
-----
R
-----------
A
S
T
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
F
V
N
P
G
-
E
----
D
-
E
-----------
V
------
S
R
V
V
F
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
-
V
S
V
F
A
C
F
L
N
--------------------------------------------------------------------------------------------------------------------------------------------
63
Fugue
63.50
18%
-84
- C2 -
2Q06
-
?
A:
[22-496]
----------A
T
E
I
R
A
S
V
G
R
M
V
G
G
I
-
G
R
F
Y
I
Q
M
C
T
E
L
K
L
S
D
Q
E
G
R
L
I
Q
N
S
I
---
T
I
E
R
-----
M
V
L
S
A
F
D
E
R
R
N
R
Y
K
D
-----
P
-
K
K
T
G
-
G
-
P
-
I
Y
R
R
R
D
G
K
--
W
V
R
--------------
E
L
I
L
Y
D
K
E
---
E
--
I
-
R
R
I
W
R
Q
A
N
NG
E
D
A
T
A
G
L
T
H
M
M
I
W
H
-
S
N
L
N
D
A
T
Y
--
Q
R
T
R
A
L
V
R
T
--
G
M
D
P
R
M
C
S
L
M
Q
-
G
S
T
L
P
R
-
R
S
G
A
A
G
A
A
I
K
G
------------------
V
G
T
M
V
M
E
L
I
R
M
I
K
R
G
I
N
D
---
R
--
N
F
W
R
G
E
N
G
R
R
T
R
I
A
Y
E
R
M
C
N
I
L
K
G
K
--------
F
Q
T
A
A
Q
K
A
M
M
D
Q
V
R
E
S
R
N
P
----
G
N
A
E
I
E
D
L
I
F
L
A
R
------
S
A
---------
L
-
I
L
R
G
S
I
A
H
K
S
-
C
L
P
A
C
V
Y
-----------------
G
L
A
V
A
S
-
G
Y
-
D
---
F
---
E
--
R
E
G
Y
S
L
V
---
G
---
I
-------
D
-------
P
-----
F
-----
R
----
L
L
Q
N
S
Q
V
F
S
L
I
-----------------------------------------
R
P
N
E
N
P
A
H
K
S
Q
L
V
W
M
A
C
---
H
S
A
A
F
E
D
L
R
V
-
S
-
S
--
F
-
I
-----------
R
------
G
T
R
V
I
P
R
G
Q
L
---
S
T
R
G
---
V
Q
I
A
S
N
E
N
V
E
A
M
D
S
S
T
L
E
L
R
S
R
Y
W
---------
A
I
R
T
R
S
G
G
N
T
N
Q
Q
R
A
S
A
G
Q
I
S
V
Q
P
T
F
S
V
Q
R
N
L
P
F
E
R
A
T
I
M
A
A
F
K
G
N
T
E
G
R
------
T
S
D
M
R
T
E
I
I
R
M
M
E
S
A
R
P
E
D
V
S
F
Q
G
R
G
V
F
E
LSD
E
K
A
T
N
P
I
V
P
S
F
D
M
S
N
EGSY
F
F
G
D
N
A
E
E
Y
50
HHSearch
61.85
16%
-144
- C4 -
2KS9
1
NK1R_HUMAN
A:
[36-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
A
Y
T
V
I
V
V
T
S
V
-
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
-----
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
---
F
T
Y
A
V
H
----------------------
N
E
W
Y
Y
-
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
------
Q
P
-----
R
LS
A
T
-
A
T
K
V
V
I
C
V
I
W
-
V
L
A
L
L
L
A
-----------------
F
P
Q
G
Y
Y
-
S
T
-
T
ETM
P
---
S
--
R
V
V
C
M
I
E
WPE
H
---
P
-------
N
-------
K
IY
E
K
V
Y
H
I
C
V
T
V
----
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
----
T
L
W
A
S
E
I
P
G
DS
S
-----------
D
R
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
--
N
-
P
-----------
D
LYLKK-
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
-
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
-------------------------------------------------------------------------------------
39
HHSearch
60.69
12%
-142
- C4 -
2Z73
5
OPSD_TODPA
A:
[35-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
-
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
-----
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
---
M
T
I
S
C
F
L
---------------------
K
K
W
I
F
-
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
------
A
A
S
K
K
M
-
S
--
H
R
-
R
A
F
I
M
I
I
F
V
W
-
L
W
S
V
L
W
A
-----------------
I
G
P
I
F
G
W
G
A
-
Y
T
L
E
G
---
V
--
L
C
N
C
S
F
D
---
Y
---
I
-------
S
RD
S
T
T
R
S
N
I
L
C
M
-
F
-----
I
----
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
----
S
V
S
N
H
E
K
E
M
--
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
--
G
-
P
LE---------
W
------
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
-
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
-----------------------------------------------------------------------------------------------------
44
HHSearch
54.48
12%
-102
- C4 -
1U19
14
OPSD_BOVIN
A:
[46-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
M
F
L
L
I
M
L
G
F
-
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
-----
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
---
L
Y
T
S
L
H
----------------------
G
Y
F
V
F
-
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
--
G
--
E
N
-
H
A
I
M
G
V
A
F
T
W
-
V
M
A
L
A
C
A
-----------------
A
P
P
L
V
G
W
S
R
-
Y
I
--
P
E
G-
M
--
Q
C
S
C
G
I
D
---
Y
---
Y
TPHEETN
N
E
S
-----
F
-----
V
-----
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
----
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
--
Q
-----------
E
-
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
-
F
T
H
Q
-
G
S----------
D
------
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
-
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
54.36
32%
-45
- C5 -
4RWF
2
A:
[482-568]
----------------------------------------------------------------
I
M
T
A
Q
Y
E
C
Y
Q
K
I
M
Q
-----
D
P
I
Q
Q
A
E
G
V
Y
-
C
N
R
T
W
D
G
W
L
C
W
N
D
V
---
A
A
G
T
E
S
M
Q
L
C
P
D
Y
F
Q
D
F
D
---
P
--
S
-
E
K
V
T
K
I
C
D
--
Q
D
G
N
W
F
R
H
P
A
S
N
R
T
W
T
N
Y
T
Q
C
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
53.73
20%
-41
- C5 -
2QKH
1
GIPR_HUMAN
A:
[30-119]
--------------------------------------------------------
G
E
L
Y
Q
--
R
W
E
R
Y
R
R
E
C
Q
E
T
L
A
A
-----
A
-
E
P
P
S
G
L
-
A
-
C
N
G
S
F
D
M
Y
V
C
W
D
Y
A
---
A
P
N
A
T
A
R
A
S
C
P
W
Y
L
P
W
H
H
---
H
VA
A
-
G
F
V
L
R
Q
C
G
--
S
D
G
Q
W
G
L
-------
W
R
D
H
T
Q
C
E
N
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
53.72
32%
-37
- C5 -
3N7S
2
CALRL_HUMAN
B:
[23-109]
----------------------------------------------------------------
I
M
T
A
Q
Y
E
C
Y
Q
K
I
M
Q
-----
D
----
A
E
G
V
Y
-
C
N
R
T
W
D
G
W
L
C
W
N
D
V
---
A
A
G
T
E
S
M
Q
L
C
P
D
Y
F
Q
D
F
D
---
P
--
S
-
E
K
V
T
K
I
C
D
--
Q
D
G
N
W
F
R
H
P
A
S
N
R
T
W
T
N
Y
T
Q
C
N
V
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
53.56
13%
-131
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[43-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
A
Y
A
L
V
F
L
L
S
L
-
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
-----
L
L
N
L
A
L
A
D
L
L
F
A
L
T
L
P
I
W
-------
A
A
S
-
K
V
-------------------
N
G
W
I
F
-
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
------
R
T
-----
L
TQ
K
R
H
L
V
K
F
V
C
L
G
C
W
-
G
L
S
M
N
L
S
-----------------
L
P
F
F
L
F
-
R
Q
A
Y
---
H
PNN
S
--
S
P
V
C
Y
E
V
---
L
GND
T
-------
A
K------
W
RM---
V
LR---
I
LPHT
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
----
G
F
T
L
R
T
L
F
K
----
A
-------------------
H
M
G
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
--
M
-
R
TQVIQE
S
C
E
R
R
N
------
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
-
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
-----------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
52.80
32%
-37
- C5 -
3N7R
1
CALRL_HUMAN
B:
[23-109]
----------------------------------------------------------------
I
M
T
A
Q
Y
E
C
Y
Q
K
I
M
Q
-----
D
----
A
E
G
V
Y
-
C
N
R
T
W
D
G
W
L
C
W
N
D
V
---
A
A
G
T
E
S
M
Q
L
C
P
D
Y
F
Q
D
F
D
---
P
--
S
-
E
K
V
T
K
I
C
D
--
Q
D
G
N
W
F
R
H
P
A
S
N
R
T
W
T
N
Y
T
Q
C
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
52.61
32%
-37
- C5 -
3N7S
1
CALRL_HUMAN
A:
[23-109]
----------------------------------------------------------------
I
M
T
A
Q
Y
E
C
Y
Q
K
I
M
Q
-----
D
P
I
---
E
G
V
Y
-
C
N
R
T
W
D
G
W
L
C
W
N
D
V
---
A
A
G
T
E
S
M
Q
L
C
P
D
Y
F
Q
D
F
D
---
P
--
S
-
E
K
V
T
K
I
C
D
--
Q
D
G
N
W
F
R
H
P
A
S
N
R
T
W
T
N
Y
T
Q
C
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
52.07
32%
-40
- C5 -
3N7R
1
CALRL_HUMAN
A:
[23-109]
----------------------------------------------------------------
I
M
T
A
Q
Y
E
C
Y
Q
K
I
M
Q
-----
D
P------V
Y
-
C
N
R
T
W
D
G
W
L
C
W
N
D
V
---
A
A
G
T
E
S
M
Q
L
C
P
D
Y
F
Q
D
F
D
---
P
--
S
-
E
K
V
T
K
I
C
D
--
Q
D
G
N
W
F
R
H
P
A
S
N
R
T
W
T
N
Y
T
Q
C
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
51.36
27%
-20
- C5 -
2X57
-
VIPR2_HUMAN
A:
[47-114]
---------------------------------------------------------------------------------------
E
K
H
K
-
A
-
C
S
G
V
W
D
N
I
T
C
W
R
P
A
---
N
V
G
E
T
V
T
V
P
C
P
K
V
F
S
N
F
Y
---
S
--
K
A
G
N
I
S
K
N
C
T
--
S
D
G
-
W
------
S
E
T
F
P
D
F
V
D
A
C
G
Y
S
D
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
50.79
23%
-64
- C5 -
2XDG
2
GHRHR_HUMAN
A:
[2-85]
---------------------------------------------------------------
M
L
R
E
D
E
S
A
C
L
Q
A
A
E
E
-------
M
P
Q
T
T
L
-
G
-
C
P
A
T
W
D
G
L
L
C
W
P
T
A
---
G
S
G
E
W
V
T
L
P
C
P
D
F
F
S
H
F
S
---
S
E-
S
-
G
A
V
K
R
D
C
T
--
I
T
G
W
S
E
P
-------
F
P
P
Y
P
V
A
C
P
V
P
L
E
L
L
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
50.65
32%
-33
- C5 -
3N7P
4
CALRL_HUMAN
A:
[23-109]
----------------------------------------------------------------
I
M
T
A
Q
Y
E
C
Y
Q
K
I
M
Q
-----
D
P
I
Q
Q
A
E
G
V
Y
-
C
N
R
T
W
D
G
W
L
C
W
N
D
V
---
A
A
G
T
E
S
M
Q
L
C
P
D
Y
F
Q
D
F
D
---
P
--
S
-
E
K
V
T
K
I
C
D
--
Q
D
G
N
W
F
R
H
P
A
S
N
R
T
W
T
N
Y
T
Q
C
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
49.42
28%
-58
- C5 -
3N94
1
MALE_ECOLI
A:
[374-468]
-----------------------------------------------------------
F
A
--
I
F
K
K
E
Q
A
M
C
L
E
K
I
Q
R
A
N
E
L
M
G
-
F
N
D
S
S
P
-
G
-
C
P
G
M
W
D
N
I
T
C
W
K
P
A
---
H
V
G
E
M
V
L
V
S
C
P
E
L
F
R
I
F
N
PDQ
D
--
M
-
G
V
V
S
R
N
C
T
--
E
D
G
-
W
S
E
------
P
F
P
H
Y
F
D
A
C
G
F
D
E
Y
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
44.91
34%
-102
- C4 -
4K5Y
4
CRFR1_HUMAN (first)
A:
[284-423]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
M
F
I
C
I
G
W
-
G
V
P
F
P
I
I
-----------------
V
A
W
A
I
G
-
K
L
-
Y
---
Y
---
D
--
N
E
K
C
W
A
G
---
K
---
R
-------
P
-------
G
-----
V
YT---
D
----
Y
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
-----
R
-----------
A
S
T
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
F
V
N
----------
E
-----------
V
------
S
R
V
V
F
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
-
V
S
V
F
A
C
F
L
N
S
-------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
44.80
34%
-107
- C4 -
4K5Y
7
CRFR1_HUMAN (first)
B:
[284-423]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
M
F
I
C
I
G
W
-
G
V
P
F
P
I
I
-----------------
V
A
W
A
I
G
-
K
L
-
Y
---
Y
---
D
--
N
E
K
C
W
A
G
---
K
---
R
----------------------YT---
D
----
Y
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
-----
R
-----------
A
S
T
T
S
E
T
I
Q
A
R
K
A
V
K
A
T
L
V
L
L
P
L
L
G
I
T
Y
M
L
A
-----------------------------------
V
F
I
Y
F
N
A
F
L
E
S
F
Q
G
F
F
-
V
S
V
F
A
C
F
L
N
S
-------------------------------------------------------------------------------------------------------------------------------------------