@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
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Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MAPK5_HUMAN: (2013-07-23 )
MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQEAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
Atome Classification :
(34 SA)
.........10........20......-..30........40........50..--------.--...--------..--60--.-------........70.-----........80........90.-.......100.......110.....--..120.......130.......140........150.......160.......170-..--.---..-.--.---180........190.......200.......210.......220.......230.......240.......250--.......260-------------------......--------.270.......280.......290..-----.....300.-.---..-...310..-......320........330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSEESDMDKAIKETSILEEYSINWTQK-LGAGISGPVRVCVKKSTQERFALKIL--------L--DRP--------KA--R---N-------EVRLHMMCA-T-----HPNIVQIIEVFANSVQFPHES-SPRARLLIVMEMMEGGELFHRISQH--RHFTEKQASQVTKQIALALRHCHL-LNIAHRDLKPENLLFKDNSLDAPVKLCDFGF-AK--I---DQ-G--D---LM-TPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPK--DMRRKIMTGS-------------------FEFPEE--------EWSQISEMAKDVVRKLLKVKPEERLT-----IEGVLDHPW-L---NS-TEALD-NV-LPSAQLMM-DKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQEAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
16
PsiBlast_PDB
79.82
43%
-107
- C2 -
3KA0
1
MAPK2_HUMAN
A:
[8-318]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
--
D
C
P
--------
K
A
--
R
---
R
-------
E
V
E
L
H
W
R
A
S
-
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
-------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
-
A
K
ET----------------------------------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
------------
G
M
K
T
R
I
R
M
G
Q
-------------------
Y
E
F
P
N
P
--------
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
---
Q
S
-
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
79.59
43%
-106
- C2 -
2PZY
1
MAPK2_HUMAN
C:
[14-319]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
--
D
C
P
--------
K
A
--
R
---
R
-------
E
V
E
L
H
W
R
A
S
-
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
-------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
-
A
K
ET
T
---------------------
P
Y
Y
V
A
P
E
V
L
------------------
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-
N
H
G
L
A
I
S
P
--
G
M
K
T
R
I
R
M
G
Q
-------------------
Y
E
F
P
N
P
--------
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
---
Q
S
-
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
-----------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
77.85
46%
-101
- C2 -
1NXK
1
MAPK2_HUMAN
A:
[52-345]
--------
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
--
D
C
P
--------
K
A
--
R
---
R
-------
E
V
E
L
H
W
R
A
S
-
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
-------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
---
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
-
A
K
--
E
---
T
T
----------------
P
Y
Y
V
A
P
E
V
L
------------------
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
-
H
G
L
A
I
S
P
--
G
M
K
T
R
I
R
M
G
Q
-------------------
Y
E
F
P
N
P
--------
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
-
I
---
M
Q
S
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
K
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
77.20
43%
-112
- C2 -
3R2Y
1
MAPK2_HUMAN
A:
[9-300]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
--
D
C
P
--------
K
A
--
R
---
R
-------
E
V
E
L
H
W
R
A
S
-
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
-------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
-
A
K
ET
T
-----------------------------------------------------
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
-------------
M
K
T
R
I
R
M
G
Q
-------------------
Y
E
F
P
N
P
--------
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
---
Q
S
-
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
K
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
77.18
42%
-103
- C2 -
3R1N
1
MAPK3_HUMAN
A:
[3-312]
-----------
K
K
Y
A
V
T
D
D
Y
Q
L
S
-
K
Q
V
-
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
--------
Y
--
D
S
P
--------
K
A
--
R
---
Q
-------
E
V
D
H
H
W
Q
A
S
-
G
-----
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
----
H
H
G
---
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
G--
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
-
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
-
A
K
E-
T
---
T
---------------------------------------------
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
Y
------------------------------------------
G
F
P
N
P
--------
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
-----
I
T
Q
F
M
N
H
P
W
-
I
---
N
Q
-
S
M
V
V
P
-
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
-----------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
77.15
42%
-113
- C2 -
1NY3
1
MAPK2_HUMAN
A:
[54-345]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
--
D
C
P
--------
K
A
--
R
---
R
-------
E
V
E
L
H
W
R
A
S
-
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
-------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
-
A
K
ET
T
---
S
H
----------------
P
Y
Y
V
A
P
E
V
L
------------------
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-----------
G
M
K
T
R
I
R
M
G
Q
-------------------
Y
E
F
P
N
P
--------
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
---
Q
S
-
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
K
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
76.63
42%
-105
- C2 -
3FHR
1
MAPK3_HUMAN
A:
[22-331]
-----------
K
K
Y
A
V
T
D
D
Y
Q
L
S
-
K
Q
V
-
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
--------
Y
--
D
S
P
--------
K
A
--
R
---
Q
-------
E
V
D
H
H
W
Q
A
S
-
G
-----
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
----
H
H
G
---
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
D-
Q
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
-
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
-
A
K
E-
T
--------------------------------------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
-------------------------------------------
G
F
P
N
P
--------
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
-----
I
T
Q
F
M
N
H
P
W
-
I
---
N
Q
-
S
M
V
V
P
-
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
-----------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
76.50
43%
-109
- C2 -
2PZY
1
MAPK2_HUMAN
B:
[14-305]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
--
D
C
P
--------
K
A
--
R
---
R
-------
E
V
E
L
H
W
R
A
S
-
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
-------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
-
A
K
ET
T
---------------------
P
Y
Y
V
A
P
E
V
L
------------------
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-----------
G
M
K
T
R
I
R
M
G
Q
-------------------
Y
E
F
P
N
P
--------
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
---
Q
S
-
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
K
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
75.92
43%
-103
- C2 -
3FYK
1
MAPK2_HUMAN
X:
[10-320]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
--
D
C
P
--------
K
A
--
R
---
R
-------
E
V
E
L
H
W
R
A
S
-
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
-------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
-
A
K
ET
T
---
S
-----------------------------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------------------
G
Q
-------------------
Y
E
F
P
N
P
--------
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
---
Q
S
-
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
75.21
42%
-105
- C2 -
3SHE
1
MAPK3_HUMAN
A:
[3-312]
-----------
K
K
Y
A
V
T
D
D
Y
Q
L
S
-
K
Q
V
-
L
G
L
G
V
N
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
--------
Y
--
D
S
P
--------
K
A
--
R
---
Q
-------
E
V
D
H
H
W
Q
A
S
-
G
-----
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
----
H
H
G
---
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
----
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
-
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
-
A
K
E-
T
--------------------------------------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
Y
------------------------------------------
G
F
P
N
P
--------
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
-----
I
T
Q
F
M
N
H
P
W
-
I
---
N
Q
-
S
M
V
V
P
-
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
-----------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.66
43%
-106
- C2 -
2PZY
1
MAPK2_HUMAN
A:
[14-306]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
--
D
C
P
--------
K
A
--
R
---
R
-------
E
V
E
L
H
W
R
A
S
-
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
-------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
---
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
-
A
K
ET
T
---------------------
P
Y
Y
V
A
P
E
V
L
------------------
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-
N
H
G
L
A
I
S
P
--
G
M
K
T
R
I
R
M
G
Q
-------------------
Y
E
F
P
N
P
--------
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
---
Q
S
-
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
K
E
D
K
------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.08
43%
-101
- C2 -
3FYJ
1
MAPK2_HUMAN
X:
[10-320]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
--
D
C
P
--------
K
A
--
R
---
R
-------
E
V
E
L
H
W
R
A
S
-
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
-------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
-
A
K
ET
T
---
S
-----------------------------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------------------
G
Q
-------------------
Y
E
F
P
N
P
--------
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
---
Q
S
-
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.04
43%
-107
- C2 -
2P3G
1
MAPK2_HUMAN
X:
[10-320]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
--
D
C
P
--------
K
A
--
R
---
R
-------
E
V
E
L
H
W
R
A
S
-
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
-------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
-
A
K
ET
T
---
S
-----------------------------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------------------
G
Q
-------------------
Y
E
F
P
N
P
--------
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
---
Q
S
-
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
73.05
42%
-106
- C2 -
3FXW
1
MAPK3_HUMAN
A:
[22-331]
-----------
K
K
Y
A
V
T
D
D
Y
Q
L
S
-
K
Q
V
-
L
G
L
G
V
-
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
--------
Y
--
D
S
P
--------
K
A
--
R
---
Q
-------
E
V
D
H
H
W
Q
A
S
-
G
-----
G
P
H
I
V
C
I
L
D
V
Y
E
N
M
----
H
H
G
---
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
D-
Q
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
-
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
-
A
K
E----------------------------------------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
-------------------------------------------
G
F
P
N
P
--------
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
-----
I
T
Q
F
M
N
H
P
W
-
I
---
N
Q
-
S
M
V
V
P
-
Q
T
P
L
H
T
A
R
V
L
Q
E
D
K
D
H
W
D
E
V
K
E
E
M
T
S
A
L
A
T
M
R
V
-----------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
70.77
40%
-98
- C2 -
3M42
1
MAPK2_HUMAN
A:
[10-299]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
--
D
C
P
--------
K
A
--
R
---
R
-------
E
V
E
L
H
W
R
A
S
-
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
-------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
-
A
K
--
E
---
T
T
-
G
--
E
-----------------------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
--------
P
--
G
M
K
T
R
I
R
M
G
Q
-------------------
Y
E
F
P
N
P
--------
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
---
Q
S
-
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
70.45
40%
-95
- C2 -
3M2W
1
MAPK2_HUMAN
A:
[10-299]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
--
D
C
P
--------
K
A
--
R
---
R
-------
E
V
E
L
H
W
R
A
S
-
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
-------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
-
A
K
--
E
---
T
T
-
G
--
E
-----------------------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
--------
P
--
G
M
K
T
R
I
R
M
G
Q
-------------------
Y
E
F
P
N
P
--------
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
---
Q
S
-
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
70.09
40%
-97
- C2 -
3KGA
1
MAPK2_HUMAN
A:
[10-299]
----------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
-
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
--------
Q
--
D
C
P
--------
K
A
--
R
---
R
-------
E
V
E
L
H
W
R
A
S
-
Q
-----
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
-------
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
-
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
-
A
K
--
E
---
T
T
-
G
--
E
-----------------------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
--------
P
--
G
M
K
T
R
I
R
M
G
Q
-------------------
Y
E
F
P
N
P
--------
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
-----
I
T
E
F
M
N
H
P
W
I
M
---
Q
S
-
T
K
V
P
Q
-
T
P
-
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
68.88
36%
-121
- C2 -
3KN5
1
KS6A5_HUMAN
A:
[2-280]
-----------
K
D
S
P
F
Y
Q
H
Y
D
L
D
L
K
D
K
P
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
--------
S
--
K
R
M
--------
E
A
N
T
Q
---
K
-------
E
I
T
A
L
K
L
C
E
-
G
-----
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
-----------
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
--
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
-
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
----
L
E
I
K
I
I
D
F
G
F
-
A
R
--
L
K
P
P-----------------------------
N
------------------
G
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
-------
C
T
S
A
V
E
I
M
K
K
I
K
K
G
D
-------------------
F
S
F
E
G
E
--------
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
-----
M
S
G
L
R
Y
N
E
W
-
L
---
Q
D
-
G
S
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
66.24
36%
-116
- C2 -
3KN5
1
B:
[2-280]
-----------
K
D
S
P
F
Y
Q
H
Y
D
L
D
L
K
D
K
P
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
--------
S
--
K
R
M
--------
E
A
N
T
Q
---
K
-------
E
I
T
A
L
K
L
C
E
-
G
-----
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
-----------
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
--
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
-
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
----
L
E
I
K
I
I
D
F
G
F
-
A
R
--
L
K
P
P-----------------------------
N
------------------
G
Y
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
S
H
D
R
S
L
T
C
T
S
A
V
E
I
M
K
K
I
K
K
G
D
-------------------
F
S
F
E
G
E
--------
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
-----
M
S
G
L
R
Y
N
E
W
-
L
---
Q
D
-
G
S
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
66.19
34%
-115
- C2 -
2WEL
7
KCC2D_HUMAN
A:
[1-264]
--------------
S
M
T
D
E
Y
Q
L
--
F
E
E
-
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
NTKKLS
A
-
R
--
D
H
Q
--------
K
L
--
E
---
R
-------
E
A
R
I
C
R
L
L
--
K
-----
H
P
N
I
V
R
L
-----------
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
-
A
I
--
E
---
V
Q
-
G
--
D
QQA
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
------------------
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-------
L
Y
Q
Q
I
K
A
G
A
-------------------
Y
D
F
P
S
P
--------
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
S
E
A
L
K
H
P
W
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
66.04
34%
-112
- C2 -
2VN9
2
KCC2D_HUMAN
A:
[1-264]
--------------
S
M
T
D
E
Y
Q
L
--
F
E
E
-
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
NTKKLS
A
-
R
--
D
H
Q
--------
K
L
--
E
---
R
-------
E
A
R
I
C
R
L
L
--
K
-----
H
P
N
I
V
R
L
-----------
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
-
A
I
--
E
---
V
Q
-
G
--
D
QQA
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
------------------
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-------
L
Y
Q
Q
I
K
A
G
A
-------------------
Y
D
F
P
S
P
--------
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
S
E
A
L
K
H
P
W
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
65.94
34%
-117
- C2 -
2YCR
1
CHK2_HUMAN
A:
[7-278]
--------------
A
L
R
D
E
Y
I
M
S
K
T
---
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
--
K
--------------
N
---
V
-------
E
T
E
I
E
I
L
K
K
L
N
-----
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
------------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
-
S
K
--
I
L
--
G
E
-
T
--
S
---
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---------------
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
--
D
---
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
--------
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
-
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
65.62
34%
-111
- C2 -
2VN9
1
KCC2D_HUMAN
B:
[1-264]
--------------
S
M
T
D
E
Y
Q
L
--
F
E
E
-
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
NTKKLSA-
R
--
D
H
Q
--------
K
L
--
E
---
R
-------
E
A
R
I
C
R
L
L
--
K
-----
H
P
N
I
V
R
L
-----------
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
-
A
I
--
E
---
V
Q
-
G
--
D
QQA
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
------------------
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-------
L
Y
Q
Q
I
K
A
G
A
-------------------
Y
D
F
P
S
P
--------
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
S
E
A
L
K
H
P
W
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
65.38
34%
-115
- C2 -
2YCS
1
CHK2_HUMAN
A:
[7-278]
--------------
A
L
R
D
E
Y
I
M
S
K
T
---
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
--
K
--------------
N
---
V
-------
E
T
E
I
E
I
L
K
K
L
N
-----
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
------------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
-
S
K
--
I
L-----
T
--
S
---
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---------------
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
--
D
---
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
--------
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
-
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
64.91
36%
-113
- C2 -
2JAM
3
KCC1G_HUMAN
A:
[17-285]
----------------------------
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
--------
K
--
K
S
--------------
S
L
E
N
-------
E
I
A
V
-
L
K
K
I
-
K
-----
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
-----------
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
--
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
K
I
M
I
T
D
F
G
L
-
S
K
--
M
---
E
Q
-
N
--
G
---
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
-
A
Q
K
-----------------
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
-------
L
F
E
K
I
K
E
G
Y
-------------------
Y
E
F
E
S
P
--------
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
-
I
---
D
G
-
N
T
A
L
H
R
D
I
-
Y
P
S
V
S
L
Q
I
-
Q
K
------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
64.86
33%
-113
- C2 -
3IGO
8
?
A:
[30-310]
----------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
-----------
N
K
A
--------
S
A
--
K
---
N
KT
S
T
I
L
R
E
V
E
L
-
L
K
K
L
-
D
-----
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
-----------
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
-
S
T
C-
F
---
Q
Q
-
N
--
T
----------
T
A
Y
Y
I
A
P
E
V
L
R
G
-------------------
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
-------
D
I
L
K
R
V
E
T
G
K
-------------------
Y
A
F
D
L
P
--------
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
-
I
Q
K
Y
S
S
-
E
T
P
T
I
-
S
D
-
L
P
S
L
E
------
S
A
M
T
N
I
R
Q
F
Q
A
E
K
-----------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
64.19
35%
-122
- C2 -
4GV1
5
AKT1_HUMAN
A:
[7-270]
----------------
M
N
E
F
E
Y
L
--
K
L
-
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
--------
K
--
K
E
V
I
V
A
K
DE
V
A
H
T
--
L
---
T
-------
E
N
R
V
L
Q
N
S
--
R
-----
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
-----------
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
---
D
G
H
I
K
I
T
D
F
G
L
-
C
K
--
E
---
G
I
K
D
GA
T
---
M
K
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
------------------
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
-----
E
--
K
L
F
E
L
I
L
M
E
E
-------------------
I
R
F
P
R
------------
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
K
E
I
M
Q
H
R
F
-
F
---
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
63.82
34%
-114
- C2 -
2YIQ
1
CHK2_HUMAN
A:
[7-278]
--------------
A
L
R
D
E
Y
I
M
S
K
T
---
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
--------
S
--
K
------------------
V
-------
E
T
E
I
E
I
L
K
K
L
N
-----
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
------------
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
-
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
-
S
K
--
I
L
--
G
E
-
T
--
S
---
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---------------
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-
S
E
H
R
T
Q
V
S
L
K
--
D
---
Q
I
T
S
G
K
-------------------
Y
N
F
I
P
E
--------
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
-
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
62.44
36%
-109
- C2 -
2JAM
3
KCC1G_HUMAN
B:
[17-285]
----------------------------
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
--------
K
--
K
S
--------------
S
L
E
N
-------
E
I
A
V
-
L
K
K
I
-
K
-----
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
-----------
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
--
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
K
I
M
I
T
D
F
G
L
-
S
K
--
M
---
E
Q
-
N
--
G
---
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
-
A
Q
K
-----------------
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
-------
L
F
E
K
I
K
E
G
Y
-------------------
Y
E
F
E
S
P
--------
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
-
I
---
D
G
-
N
T
A
L
H
R
D
I
-
Y
P
S
V
S
L
Q
I
-
Q
K
------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
62.42
31%
-131
- C2 -
3LIJ
1
?
A:
[42-295]
------------------------
V
K
K
-
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
--------
R
KS
S
N
S
--------
K
L
--
L
---
E
-------
E
V
A
V
-
L
K
L
L
-
D
-----
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
-----------
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
--
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
E
K
D
A
L
I
K
I
V
D
F
G
L
-
S
A
--
V
F
E
-
N
Q
-
K
--
K
---
M
K
-
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
K
K
-------------------
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
-----
T
D
Q
--
E
I
L
R
K
V
E
K
G
K
-------------------
Y
T
F
D
S
P
--------
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
-----
A
Q
Q
A
L
E
H
P
W
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
62.37
33%
-122
- C2 -
3HZT
9
?
A:
[9-263]
------------------------
V
K
K
-
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
KKSSVTTT
S
--
N
S
G
--------
A
L
--
L
---
D
-------
E
V
A
V
-
L
K
Q
L
-
D
-----
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
-----------
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
--
Q
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
R
D
A
L
I
K
I
V
D
F
G
L
S
A
H
--
F
---
E
V
-
G
-------------
T
A
Y
Y
I
A
P
E
V
L
R
K
K
-------------------
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
-----
T
D
Q
--
E
I
L
K
R
V
E
K
G
K
-------------------
F
S
F
D
P
P
--------
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
-----
A
E
E
A
L
N
H
P
W
-
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
57.89
35%
-111
- C2 -
2W4O
1
KCC4_HUMAN
A:
[60-314]
--------------------------
E
-
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K-------------------------------------
I
G
V
-
L
L
R
L
-
S
-----
H
P
N
I
I
K
L
K
E
I
F
----
E
T
P
T
E
I
-
S
------
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
--
G
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
P
D
A
P
L
K
I
A
D
F
---------------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
------------------
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
F
------
M
F
R
R
I
L
N
C
E
-------------------
Y
Y
F
I
S
P
--------
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
-----
T
F
Q
A
L
Q
H
P
W
-
V
---
T
G
-
K
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
56.70
35%
-118
- C2 -
4FG8
1
KCC1A_HUMAN
A:
[26-283]
----------------------------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--------
A
--
K
E
------------------------------
N
E
I
A
-
V
L
H
K
IK
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
-----------
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
I
M
I
S
D
F
----------------------------
T
P
G
Y
V
A
P
E
V
L
-
A
Q
K
-----------------
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
-------
L
F
E
Q
I
L
K
A
E
-------------------
Y
E
F
D
S
P
--------
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
-
I
---
A
G
-
D
T
A
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
HHSearch
50.48
33%
-95
- C2 -
3ZDU
3
CDKL3_HUMAN
A:
[3-289]
-----------------
E
M
Y
E
T
L
--
G
K
-
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
N
T
G
Q
I
V
A
I
K
I
F
--------
Y
-----N
K
------
I
A
--
M
---
R
-------
E
I
K
F
L
K
Q
F
--
H
-----
H
E
N
L
V
N
L
I
E
V
F
R
Q
K
-----------
K
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
E
L
Q
H
Y
C
--
H
G
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
-
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
---
S
G
I
T
K
L
C
D
F
G
F
-
A
R
--
T
---------
D
I--
Y
D
-
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
-----------------
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
G
N
P
Y
L
P
S
S
S
D
-----
L
--
D
L
L
H
K
I
V
L
K
V
GNLS
P
H
L
Q
N
I
F
S
K
SPIFAG
V
V
L
P
Q
V
Q
H
P
KN
A
R
K
K
Y
P
K
L
N
G
L
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
-----
S
S
D
L
L
H
H
E
Y
-
F
---
T
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------