@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KPCZ_HUMAN: (2015-10-11 )
MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
Atome Classification :
(80 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200........210..---.....220.......230.......240.......250.......260........270---..-..--....280.....-..-290.......300.......-310.......320..-.....330.......340..-.-.----...350.......360......-.-370........380...-....390.......400......-.--410........420...-----.---.-----..430.......440.....-..450..--.....460.......470..--....---.--480.......490.......500.......510.......520---.......530.......540----........550........560.......570-..-.......580.......590
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPSRTGPKMEGSG
G
R
V
R
L
K
A
HYG
G
D
I
F
I
T
SVD
A
A
T
T
F
E
E
L
C
E
E
V
R
D
M
C
R
L
HQQH
P
L
T
L
K
W
VDSEGDPCTV
S
S
Q
M
E
L
E
E
A
F
R
L
A
R
Q
CRDE
G
L
I
I
H
VFPSTPEQPGLPCPGE
D
K
S
I
Y
R
R
G
A
R
R
W
R
K
L
Y
R
ANG
H
L
F
Q
AKRFNR
R
A
Y
C
G
Q
C
S
E
R
I
W
G
L
A
R
Q
G
Y
R
C
I
N
C
K
L
L
V
H
KRCHGLV
P
L
T
C
R
K
H
M
D
S
VMPSQEPPVDDKNE-DADLPSEETD
G
I
A
Y
---ISSSRKHDSIKD
D
S
E
D
L
K
P
V
IDGMDG
I
K
ISQGLGL
Q
D
F
D
L
I
R
V
IGRG-S
Y
A
K
V
L
L
V
R
-L---KK-ND--
Q
I
Y
A
M
K
V
V
K
K
E
L-VH-DDEDI
D
W
V
Q
T
E
K
H
V
F
E
QASS-N
P
F
L
V
G
L
H
S
C
F
Q
T
T
S
-
R
L
F
L
V
I
E
Y
VNGG
D
L
M
F
H
M
Q
R
-
Q
-R----KL
P
E
E
H
A
R
F
Y
A
A
E
I
C
I
A
L
N
F
L
H
-E-R-G
I
I
Y
R
D
L
K
L
D
N
V
L
LD-ADG
H
I
K
L
TDYG
M
C
KEGLGPGDTT-S--TF-CGTPNYI
A
P
E
ILRG-----E---E-----YGF
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
AG-RS
P
F
D
I
I--TDNPDMN
T
E
D
Y
L
F
Q
V
I
L
EKP--IRI
P
---
R
--
F
L
S
V
K
A
S
H
V
L
K
G
F
LNK
D
P
K
E
RLGCRPQT
G
F
S
D
I
K
S
H
A
F
F
R
SI
D
---
W
D
L
L
E
K
KQALPPFQPQITD-----DYGLDNFDT-QFTSEP
V
Q
LTPD
D
E
D
A
I
K
RI---
D
Q
-
S
EFE
G
F
E
Y
I
N
P
L
LLSTEESV
4
PsiBlast_PDB
93.53
84%
-127
- C2 -
3A8W
1
KPCI_HUMAN
A:
[6-345]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
-
T
D
--
R
I
Y
A
M
K
V
V
K
K
E
L
-
V
N
-----
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
-
R
----
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
-
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
D
-----------
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
---
R
--
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
-----
E
F
G
L
D
N
F
D
S
-
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
I
V
R
K
I
---
D
Q
-
S
E
F
E
G
F
E
Y
I
N
P
L
--------
114
HHSearch
93.22
82%
-127
- C2 -
4DC2
1
KPCI_MOUSE
A:
[49-387]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
-
T
D
--
R
I
Y
A
M
R
V
V
K
K
E
L
-
V
N
-----
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
-
R
----
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
-
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
D
I
V
GS------
N
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
---
R
--
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
-----
E
F
G
L
D
N
F
D
S
-
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
I
V
R
K
I
---
D
Q
-
S
E
F
E
G
F
E
Y
I
N
P
---------
1
PsiBlast_PDB
92.65
80%
-127
- C2 -
4DC2
1
KPCI_MOUSE
A:
[49-387]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
-
T
D
--
R
I
Y
A
M
R
V
V
K
K
E
L
-
V
N
-----
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
-
R
----
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
-
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
D
I
V
GS------
N
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
---
R
--
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
-----
E
F
G
L
D
N
F
D
S
-
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
I
V
R
K
I
---
D
Q
-
S
E
F
E
G
F
E
Y
I
N
P
---------
22
PsiBlast_CBE
89.98
84%
-120
- C2 -
3A8W
1
KPCI_HUMAN
B:
[6-345]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
-
T
D
--
R
I
Y
A
M
K
V
V
K
K
E
L
-
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
-
R
----
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
---
G
D
T
T
-
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
D
-----------
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
---
R
--
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
-----
E
F
G
L
D
N
F
D
S
-
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
I
V
R
K
I
---
D
Q
-
S
E
F
E
G
F
E
Y
I
N
P
L
--------
2
PsiBlast_PDB
89.68
84%
-122
- C2 -
3ZH8
4
KPCI_HUMAN
A:
[2-343]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
-
L
---
K
K
-
T
D
--
R
I
Y
A
M
K
V
V
K
K
E
L
-
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
-
R
----
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
-
S
--
T
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
-----
E
---
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
D
I
V
--------
N
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
---
R
--
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
-----
E
----------------
Q
L
T
P
D
D
D
D
I
V
R
K
I
---
D
Q
-
S
E
F
E
G
F
E
Y
I
N
P
L
L
M
------
19
PsiBlast_PDB
77.28
45%
-119
- C2 -
3E88
1
AKT2_HUMAN
A:
[4-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
-
E
---
K
A
-
T
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
N
T
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
-
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
------
Y
N
Q
D
---
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
--
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
-----
E
V
D
T
R
Y
F
D
D
-
E
F
T
A
Q
S
I
T
I
T
--------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
R
-------
20
PsiBlast_PDB
76.54
45%
-118
- C2 -
3D0E
1
AKT2_HUMAN
A:
[4-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
-
E
---
K
A
-
T
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
N
T
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
-
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
------
Y
N
Q
D
---
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
--
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
-----
E
V
D
T
R
Y
F
D
D
-
E
F
T
A
Q
S
I
T
I
T
P
P
D
-----------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
R
-------
118
HHSearch
76.49
44%
-122
- C2 -
4GV1
5
AKT1_HUMAN
A:
[3-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
-
E
---
K
A
-
T
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
-
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
----
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
-
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
-
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
N
---------
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
--
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
-----
E
T
D
T
R
Y
F
D
E
-
E
F
T
A
Q
M
I
T
I
T
P
----
S
M
E
C
V
DSE
R
R
-
P
H
F
P
Q
F
D
Y
S
A
S
---------
11
PsiBlast_PDB
76.09
46%
-119
- C2 -
2JDO
2
AKT2_HUMAN
A:
[9-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
-
E
---
K
A
-
T
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
N
T
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
-
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
------
Y
N
Q
D
---
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
--
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
-----
E
V
D
T
R
Y
F
D
D
-
E
F
T
A
Q
S
I
T
-------------------
M
F
E
D
F
D
Y
I
A
D
W
--------
15
PsiBlast_PDB
76.07
46%
-118
- C2 -
2XH5
1
AKT2_HUMAN
A:
[9-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
-
E
---
K
A
-
T
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
N
T
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
-
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
------
Y
N
Q
D
---
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
--
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
-----
E
V
D
T
R
Y
F
D
D
-
E
F
T
A
Q
S
I
T
----------------
Q
-
E
M
F
E
D
F
D
Y
I
A
D
W
--------
12
PsiBlast_PDB
75.90
46%
-115
- C2 -
2JDR
1
AKT2_HUMAN
A:
[9-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
-
E
---
K
A
-
T
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
N
T
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
-
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
------
Y
N
Q
D
---
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
--
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
-----
E
V
D
T
R
Y
F
D
D
-
E
F
T
A
Q
S
I
T
----------------
Q
-
E
M
F
E
D
F
D
Y
I
A
D
W
--------
10
PsiBlast_PDB
75.61
46%
-117
- C2 -
1O6L
1
AKT2_HUMAN
A:
[4-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
-
E
---
K
A
-
T
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
N
T
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
-
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
------
Y
N
Q
D
---
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
--
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
-----
E
V
D
T
R
Y
F
D
D
-
E
F
T
A
Q
S
I
T
----------------
Q
-
E
M
F
E
D
F
D
Y
I
A
D
W
--------
18
PsiBlast_PDB
74.91
45%
-120
- C2 -
3E87
1
AKT2_HUMAN
A:
[4-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
-
E
---
K
A
-
T
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
N
T
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
-
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
------
Y
N
Q
D
---
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
--
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
-----
E
V
D
T
R
Y
F
D
D
-
E
F
T
A
Q
S
I
T
I
T
P
P
------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
R
-------
17
PsiBlast_PDB
74.38
45%
-116
- C2 -
1O6K
1
AKT2_HUMAN
A:
[4-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
-
E
---
K
A
-
T
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
N
T
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
-
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
------
Y
N
Q
D
---
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
--
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
-----
E
V
D
T
R
Y
F
D
D
-
E
F
T
A
Q
S
I
T
----------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
--------
14
PsiBlast_PDB
74.22
46%
-117
- C2 -
2X39
1
AKT2_HUMAN
A:
[9-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
-
E
---
K
A
-
T
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
N
T
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
-
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
------
Y
N
Q
D
---
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
--
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
-----
E
V
D
T
R
Y
F
D
D
-
E
F
T
A
Q
S
I
T
----------------
Q
-
E
M
F
E
D
F
D
Y
I
A
D
W
--------
6
PsiBlast_PDB
73.03
50%
-122
- C2 -
4RA4
1
KPCA_HUMAN
A:
[15-344]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
V
K
L
T
------
D
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
A
D
-
R
---
K
G
-
T
E
--
E
L
Y
A
I
K
I
L
K
K
D
V
-
V
I
-
Q
D
D
D
V
E
C
T
M
V
E
K
R
V
L
A
L
L
D
K
-
P
P
F
L
T
Q
L
H
S
C
F
Q
T
V
D
-
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
-
V
-
G
----
K
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
-
K
-
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
H
M
M
D
G
V
T
T
-
R
--
T
F
-
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
-----
Q
---
P
-----
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
-
Q
P
P
F
---------
D
G
E
D
E
D
E
L
F
Q
S
I
M
E
H
N
--
V
S
Y
P
---
K
--
S
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
R
L
G
C
G
P
E
-
G
E
R
D
V
R
E
H
A
F
F
R
R
I
D
---
W
E
K
L
E
N
R
E
I
Q
P
P
F
K
P
K
----------------------
G
Q
P
V
L
T
P
P
D
Q
L
V
I
A
N
I
---
D
Q
-
S
D
F
E
G
F
S
Y
V
N
P
Q
F
V
H
P
----
132
HHSearch
72.31
46%
-129
- C2 -
4EJN
3
AKT1_HUMAN
A:
[144-438]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
-
E
---
K
A
-
T
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
-
I
V
--------------
V
L
Q
N
-
S
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
----
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
-
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
------
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
N
--------
Q
-
D
H
E
K
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
--
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
-----
E
T
D
T
R
Y
F
-------------------------------------------------
13
PsiBlast_PDB
71.85
46%
-115
- C2 -
2UW9
1
AKT2_HUMAN
A:
[9-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
-
E
---
K
A
-
T
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
-
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
-
Q
N
T
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
-
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
------
Y
N
Q
D
---
H
E
R
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
--
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
-
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
-----
E
V
D
T
R
Y
F
D
D
-
E
F
T
A
Q
S
I
T
----------------
Q
-
E
M
F
E
D
F
D
Y
I
A
D
W
--------
9
PsiBlast_PDB
70.99
50%
-116
- C2 -
3TXO
1
KPCL_HUMAN
A:
[23-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
-
V
---
K
E
-
T
G
--
D
L
Y
A
V
K
V
L
K
K
D
V
-
I
L
-
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
R
N
-
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
-
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
-
S
-
R
----
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
-
D
-
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
-------------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
-----
M
---
L
-----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
-
H
A
P
F
---------
E
A
E
N
E
D
D
L
F
E
A
I
L
N
D
E
--
V
V
Y
P
---
T
--
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
-----
R
E
D
V
S
N
F
D
P
-
D
F
I
K
E
E
P
V
L
T
P
I
D
E
G
H
L
P
M
I
---
N
Q
-
D
E
F
R
N
F
E
Y
V
S
P
---------
117
HHSearch
70.90
52%
-115
- C2 -
3TXO
1
KPCL_HUMAN
A:
[23-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
-
V
---
K
E
-
T
G
--
D
L
Y
A
V
K
V
L
K
K
D
V
-
I
L
-
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
R
N
-
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
-
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
-
S
-
R
----
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
-
D
-
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
-------------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
-----
M
---
L
-----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
-
H
A
P
F
E
A
---------
E
N
E
D
D
L
F
E
A
I
L
N
D
E
--
V
V
Y
P
---
T
--
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
-----
R
E
D
V
S
N
F
D
P
-
D
F
I
K
E
E
P
V
L
T
P
I
D
E
G
H
L
P
M
I
---
N
Q
-
D
E
F
R
N
F
E
Y
V
S
P
---------
24
PsiBlast_CBE
70.75
46%
-122
- C2 -
4EJN
3
AKT1_HUMAN
A:
[147-438]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
-
E
---
K
A
-
T
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
-
I
V
--------------
V
L
-
Q
N
S
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
----
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
------
K
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
------
Y
N
Q
D
---
H
E
K
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
--
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
-----
E
T
D
T
R
Y
F
-------------------------------------------------
119
HHSearch
70.56
45%
-118
- C2 -
1XJD
1
A:
[16-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
-
F
---
K
K
-
T
N
--
Q
F
F
A
I
K
A
L
K
K
D
V
-
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
-
H
----
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
-
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
-
N
--
T
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
-----
Q
---
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
H
G
---------
Q
D
E
E
E
L
F
H
S
I
R
M
D
N
--
P
F
Y
P
---
R
--
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
-----
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
-----------------------------------------------
Q
-
N
M
F
R
N
F
S
F
------------
25
PsiBlast_CBE
69.94
46%
-128
- C2 -
3O96
1
AKT1_HUMAN
A:
[150-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
-
E
---
K
A
-
T
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
-
I
V
-
A
----------
N
R
V
L
-
Q
N
S
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
-
R
----
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
-
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
------------------
P
E
Y
L
A
P
E
V
L
E
D
-----
N
---
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
------
Y
N
Q
D
---
H
E
K
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
--
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
-
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
---------------------------------------------------------------
31
PsiBlast_CBE
68.03
39%
-104
- C2 -
4L43
1
KS6B1_HUMAN
A:
[20-345]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
-
T
G
--
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
-
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
---------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
----
I
L
K
C
K
--
L
N
L
P
---
P
--
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
-----
E
E
D
V
S
Q
F
D
S
-
K
F
T
R
Q
T
P
V
----------
S
A
---
N
Q
-
V
-
F
L
G
F
A
Y
V
A
P
S
--------
125
HHSearch
67.97
37%
-108
- C2 -
1RDQ
3
KAPCA_MOUSE
E:
[35-350]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
-
H
---
K
E
-
S
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
-
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
-
W
--
T
L
-
C
G
T
P
E
A
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
F
A
----
D
-----
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
--
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-----
P
G
D
T
S
N
F
D
D
--
Y
E
E
E
E
I
R
V
S
I
N
E
K
---------
C
G
-
K
E
F
T
E
F
--------------
131
HHSearch
67.14
39%
-115
- C2 -
3WF7
2
KS6B1_HUMAN
A:
[13-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
-
T
G
--
K
I
F
A
M
K
V
L
K
K
A
M
-
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
-
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
---
T
-
H
--
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
T
G
--------
E
N
R
K
-
K
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
--
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
--------------------------------------------------------------
58
PsiBlast_CBE
67.04
38%
-115
- C2 -
2F7E
1
KAPCA_BOVIN
E:
[41-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
-
H
---
M
E
-
T
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
-
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
---
R
T
-
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
--
F
--
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
--
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-----
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
---
F
----------------------
41
PsiBlast_CBE
65.84
41%
-106
- C2 -
4L3J
1
KS6B1_HUMAN
A:
[20-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
-
T
G
--
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
-
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
-
H
--
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
----
I
L
K
C
K
--
L
N
L
P
---
P
--
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
-------------------------------------------------------------
54
PsiBlast_CBE
65.55
38%
-115
- C2 -
2OJF
1
KAPCA_BOVIN
E:
[41-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
-
H
---
M
E
-
T
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
-
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
---
R
T
-
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
--
F
--
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
--
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-----
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
---
F
----------------------
120
HHSearch
65.34
44%
-129
- C2 -
2R5T
1
SGK1_HUMAN
A:
[34-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
-
H
---
K
A
-
E
E
--
V
F
Y
A
V
K
V
L
Q
K
K
A
-
I
L
--------------
V
L
L
K
N
V
K
-
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
-
R
----
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
-
S
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
---
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
Y
S
--------
R
N
-
T
A
E
M
Y
D
N
I
L
N
K
P
--
L
Q
L
K
---
P
--
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
-------------------------------------------------------------
59
PsiBlast_CBE
65.04
38%
-114
- C2 -
2UZW
1
KAPCA_BOVIN
E:
[26-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
-
H
---
M
E
-
T
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
-
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
---
R
T
-
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
--
F
--
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
--
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-----
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
---
F
----------------------
32
PsiBlast_CBE
65.01
39%
-106
- C2 -
4L42
1
KS6B1_HUMAN
A:
[20-343]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
-
T
G
--
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
-
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
-
H
--
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
----
I
L
K
C
K
--
L
N
L
P
---
P
--
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
----------------------------------------------
E
M
F
R
D
F
E
Y
I
A
D
W
--------
62
PsiBlast_CBE
64.84
38%
-117
- C2 -
2UZT
1
KAPCA_BOVIN
A:
[26-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
-
H
---
M
E
-
T
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
-
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
---
R
T
-
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
--
F
--
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
--
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-----
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
---
F
----------------------
56
PsiBlast_CBE
64.84
38%
-122
- C2 -
2F7Z
1
KAPCA_BOVIN
E:
[41-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
-
H
---
M
E
-
T
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
-
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
---
R
T
-
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
--
F
--
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
--
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-----
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
---
F
----------------------
33
PsiBlast_CBE
64.51
39%
-102
- C2 -
4L46
1
KS6B1_HUMAN
A:
[20-345]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
-
T
G
--
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
-
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
-----
H
--
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
----
I
L
K
C
K
--
L
N
L
P
---
P
--
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
--------
E
E
D
V
S
Q
F
D
S
-
K
F
T
R
Q
T
P
V
----------------
Q
-
V
-
F
L
G
F
T
Y
V
A
P
S
--------
55
PsiBlast_CBE
64.24
38%
-118
- C2 -
2OH0
1
KAPCA_BOVIN
E:
[41-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
-
H
---
M
E
-
T
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
-
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
---
R
T
-
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
--
F
--
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
--
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-----
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
---
F
----------------------
30
PsiBlast_CBE
64.11
39%
-98
- C2 -
4L44
1
KS6B1_HUMAN
A:
[20-345]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
-
T
G
--
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
-
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
------
H
--
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
----
I
L
K
C
K
--
L
N
L
P
---
P
--
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
-----
E
E
D
V
S
Q
-
D
S
-
K
F
T
R
Q
T
----------
S
E
S
A
---
N
Q
-
V
-
F
L
G
F
A
Y
V
A
P
S
--------
57
PsiBlast_CBE
63.95
38%
-114
- C2 -
2F7X
1
KAPCA_BOVIN
E:
[41-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
-
H
---
M
E
-
T
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
-
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
---
R
T
-
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
--
F
--
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
--
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-----
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
---
F
----------------------
61
PsiBlast_CBE
63.65
38%
-111
- C2 -
2UZU
1
KAPCA_BOVIN
E:
[26-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
-
H
---
M
E
-
T
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
-
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
---
R
T
-
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
--
F
--
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
--
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-----
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
---
F
----------------------
28
PsiBlast_CBE
63.56
43%
-124
- C2 -
2R5T
1
SGK1_HUMAN
A:
[39-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
-
H
---
K
A
-
E
E
--
V
F
Y
A
V
K
V
L
Q
K
K
A
-
I
L
--------------
V
L
L
K
N
V
K
-
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
-
R
----
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
-
S
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
---
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
Y
--------
S
R
N
T
A
E
-
M
Y
D
N
I
L
N
K
P
--
L
Q
L
K
---
P
--
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
--
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
-------------------------------------------------------------
126
HHSearch
62.97
35%
-105
- C2 -
3C4Z
1
RK_BOVIN
A:
[179-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
-
G
F
G
E
V
F
A
C
Q
-
M
---
K
A
-
T
G
--
K
L
Y
A
C
K
K
L
N
K
K
R
-
L
K
-
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
-
H
-
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
-
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
-
V
-
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
-
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
-
K
--
G
Y
-
A
G
T
P
G
F
M
A
P
E
L
L
L
G
-----
E
---
E
-----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
-
R
G
P
F
R
A
R
--
G
E
--
K
V
-
E
N
K
E
L
K
Q
R
V
L
E
Q
A
--
V
T
Y
P
---
D
--
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
---
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
VYAKN----
G
A
F
S
-------
G
V
A
F
E
K
A
D
T
E
------------
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
122
HHSearch
62.50
34%
-104
- C2 -
4AW2
3
MRCKA_RAT
A:
[70-414]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
-
L
---
K
N
-
A
D
--
K
V
F
A
M
K
I
L
N
K
W
E
-
M
L
-
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
-
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
-
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
-
D
----
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
-
Q
-
L
-
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
-
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
-
S
--
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
GGK
G
---
R
-----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
Y
A
--------
E
S
-
L
V
E
T
Y
G
K
I
M
N
H
K
ER
F
Q
F
P
TQV
T
--
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
-
S
R
E
H
R
L
G
---
Q
N
G
I
E
D
F
K
K
H
P
F
F
S
G
I
D
---
W
D
N
I
--
R
N
C
E
A
P
Y
I
P
E
V
S
S
-----
P
T
D
T
S
N
F
D
V
-
D
-----------------
S
G
---
H
H
-
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
40
PsiBlast_CBE
61.68
41%
-105
- C2 -
4L3L
1
KS6B1_HUMAN
A:
[20-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
-
T
G
--
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
-
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
-
H
--
T
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
----
I
L
K
C
K
--
L
N
L
P
---
P
--
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
-------------------------------------------------------------
52
PsiBlast_CBE
61.15
40%
-122
- C2 -
3UBD
1
KS6A3_MOUSE
A:
[26-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
---
S
G
-
S
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
-
L
K
-
V
R
D
R
V
-------
D
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
-
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-----
K
K
A
-
Y
--
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
G
K
--
D
R
K
E
T
M
T
-------
M
I
L
K
A
K
--
L
G
M
P
---
Q
--
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------
44
PsiBlast_CBE
60.88
38%
-119
- C2 -
2Z7R
1
KS6A1_HUMAN
A:
[30-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
V
---
T
R
-
P
D
SG
H
L
Y
A
M
K
V
L
K
K
A
T
-
L
K
-
V
------------
I
L
A
D
V
N
--
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
-
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
----------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
Q
---
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
Q
G
K
--
D
R
K
E
T
M
T
-------
L
I
L
K
A
K
--
L
G
M
P
---
Q
--
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
-
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------
38
PsiBlast_CBE
60.84
39%
-117
- C2 -
5D9K
2
?
A:
[32-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
---
S
G
-
S
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
-
L
K
-
V
R
D
R
V
R
-
T
K
M
E
R
D
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
-
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
----------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
G
K
--
D
R
K
E
T
M
T
-------
M
I
L
K
A
K
--
L
G
M
P
---
Q
--
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
-----------
F
Y
F
D
P
-----------------------------------------------
60
PsiBlast_CBE
60.83
38%
-108
- C2 -
2UZV
1
KAPCA_BOVIN
A:
[26-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
-
H
---
M
E
-
T
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
-
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
-
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
---
R
T
-
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-----
K
---
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
--
F
--
A
D
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
--
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-----
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
---
F
----------------------
47
PsiBlast_CBE
60.32
40%
-103
- C2 -
4NW6
1
KS6A3_HUMAN
A:
[32-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
---
S
G
-
S
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
-
L
K
-
V
R
D
R
V
R
-
T
K
M
E
R
D
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
-
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
-
Y
--
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
G
K
--
D
R
K
E
T
M
T
-------
M
I
L
K
A
K
--
L
G
M
P
---
Q
--
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
T
F
Y
F
-----
D
P
------------------------------------------------------
43
PsiBlast_CBE
60.26
38%
-119
- C2 -
2Z7S
1
KS6A1_HUMAN
A:
[30-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
V
---
T
R
-
P
D
SG
H
L
Y
A
M
K
V
L
K
--------------------
I
L
A
D
V
N
--
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
-
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
----------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
Q
---
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
Q
G
K
--
D
R
K
E
T
M
T
-------
L
I
L
K
A
K
--
L
G
M
P
---
Q
--
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
-
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------
27
PsiBlast_CBE
60.18
43%
-119
- C2 -
3HDM
1
SGK1_HUMAN
A:
[39-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
-
H
---
K
A
-
E
E
--
V
F
Y
A
V
K
V
L
Q
K
K
A
-
I
L
--------------
V
L
L
K
N
V
K
-
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
-
R
----
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
-
S
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
---
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
Y
--------
S
R
N
T
A
E
-
M
Y
D
N
I
L
N
K
P
--
L
Q
L
K
---
P
--
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
--
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
-------------------------------------------------------------
26
PsiBlast_CBE
60.10
43%
-120
- C2 -
3HDN
1
SGK1_HUMAN
A:
[39-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
-
H
---
K
A
-
E
E
--
V
F
Y
A
V
K
V
L
Q
K
K
A
-
I
L
--------------
V
L
L
K
N
V
K
-
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
-
R
----
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
-
S
--
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
-----
Q
---
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
Y
--------
S
R
N
T
A
E
-
M
Y
D
N
I
L
N
K
P
--
L
Q
L
K
---
P
--
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
--
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-----------------------------------------------------------------
37
PsiBlast_CBE
59.53
39%
-114
- C2 -
5D9K
2
?
B:
[32-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
---
S
G
-
S
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
-
L
K
-
V
R
D
R
V
R
-
T
K
M
E
R
D
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
-
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
---------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
G
K
--
D
R
K
E
T
M
T
-------
M
I
L
K
A
K
--
L
G
M
P
---
Q
--
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------
T
F
Y
F
D
P
-----------------------------------------------
45
PsiBlast_CBE
59.42
38%
-122
- C2 -
2Z7Q
1
KS6A1_HUMAN
A:
[30-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
V
---
T
R
-
P
D
SG
H
L
Y
A
M
K
V
L
---------------------
I
L
A
D
V
N
--
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
-
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
----------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
Q
---
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
Q
G
K
--
D
R
K
E
T
M
T
-------
L
I
L
K
A
K
--
L
G
M
P
---
Q
--
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
-
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-----------------------------------------------------------------
48
PsiBlast_CBE
59.15
40%
-102
- C2 -
4NW5
1
KS6A3_HUMAN
A:
[32-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
---
S
G
-
S
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
-
L
K
-
V
R
D
R
V
R
-
T
K
M
E
R
D
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
-
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
-
Y
--
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
G
K
--
D
R
K
E
T
M
T
-------
M
I
L
K
A
K
--
L
G
M
P
---
Q
--
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
T
F
Y
F
-----
D
P
------------------------------------------------------
51
PsiBlast_CBE
59.11
40%
-121
- C2 -
4EL9
1
KS6A3_MOUSE
A:
[27-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
---
S
G
-
S
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
-
L
K
-
V
R
D
R
V
R
------
D
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
-
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
---
E
K
K
A
-
Y
--
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
G
K
--
D
R
K
E
T
M
T
-------
M
I
L
K
A
K
--
L
G
M
P
---
Q
--
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------
46
PsiBlast_CBE
58.92
40%
-112
- C2 -
5D9L
2
?
A:
[32-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
---
S
G
-
S
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
-
L
K
-
V
R
D
R
V
R
-
T
K
M
E
R
D
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
-
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
----------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
G
K
--
D
R
K
E
T
M
T
-------
M
I
L
K
A
K
--
L
G
M
P
---
Q
--
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
G
R
-----
P
E
D
T
F
Y
F
D
P
-----------------------------------------------
39
PsiBlast_CBE
57.50
39%
-119
- C2 -
3G51
1
KS6A3_MOUSE
A:
[26-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
---
S
G
-
S
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
-
L
K
-
V
R
D
----------
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
-
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
---------------
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
G
K
--
D
R
K
E
T
M
T
-------
M
I
L
K
A
K
--
L
G
M
P
---
Q
--
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------
50
PsiBlast_CBE
57.36
40%
-119
- C2 -
4GUE
1
KS6A3_MOUSE
A:
[27-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
---
S
G
-
S
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
-
L
K
-
V
R
D
R
V
---------
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
-
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-----
K
K
A
-
Y
--
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
G
K
--
D
R
K
E
T
M
T
-------
M
I
L
K
A
K
--
L
G
M
P
---
Q
--
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----------------------------------------------------------------
49
PsiBlast_CBE
56.91
40%
-107
- C2 -
4NUS
1
KS6A3_HUMAN
A:
[32-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
---
S
G
-
S
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
-
L
K
-
V
R
D
R
V
R
-
T
K
M
E
R
D
I
L
V
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
-
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
-
Y
--
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
-----
R
---
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
Q
G
K
--
D
R
K
E
T
M
T
-------
M
I
L
K
A
K
--
L
G
M
P
---
Q
--
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
F
Y
-----
F
D
P
-----------------------------------------------------
34
PsiBlast_CBE
56.49
39%
-109
- C2 -
3A61
1
KS6B1_HUMAN
A:
[19-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
-
K
V
T
G
A
N
-
T
G
--
K
I
F
A
M
K
V
L
K
----------------
A
E
R
N
I
L
E
E
V
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
-
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
--------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
----
I
L
K
C
K
--
L
N
L
P
---
P
--
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------
99
PsiBlast_CBE
55.76
31%
-90
- C2 -
4AW2
4
MRCKA_RAT
A:
[44-415]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
H
R
----
E
D
F
E
I
L
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
-
L
---
K
N
-
A
D
--
K
V
F
A
M
K
I
L
N
K
W
E
-
M
L
-
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
S
--
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
-
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
-
D
----
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
-
Q
-
L
-
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
-
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
-
S
--
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
-----
M
---
E
GGKGR
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-------
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
K
E
R
--
F
Q
F
P
TQV
T
--
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
S
-
R
E
H
R
L
G
---
Q
N
G
I
E
D
F
K
K
H
P
F
F
S
G
I
D
---
W
D
N
I
R
N
C
E
--
A
P
Y
I
P
E
V
S
S
-----
P
T
D
T
S
N
F
D
V
D-----------------
S
G
----
H
H
-
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
36
PsiBlast_CBE
55.17
39%
-107
- C2 -
3A60
1
KS6B1_HUMAN
A:
[19-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
-
K
V
T
G
A
N
-
T
G
--
K
I
F
A
M
K
V
L
K
K
A
M
------------
K
A
E
R
N
I
L
E
E
V
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
-
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
-----------------
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
----
I
L
K
C
K
--
L
N
L
P
---
P
--
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----------------------------------------------------------------
111
Fugue
53.22
34%
-105
- C2 -
1CDK
2
KAPCA_PIG
A:
[8-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
-
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
---
N
T
A
------
H
------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
-G
S
F
G
R
V
M
L
V
K
-
H
---
K
E
T
G
---
N
H
F
A
M
K
I
L
D
K
Q
K
-
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
--N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
-S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
--
I
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
--
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q-
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-
K
--
G
---
R
TW
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
------KGY-------
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y-
P
P
F
F
A
D
---------
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
S-----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
-
V
N
D
I
K
N
H
K
W
F
A
---TT
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-----
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
-------
N
E
K
---
C
G
-
K
E
F
S
E
F
--------------
42
PsiBlast_CBE
53.21
41%
-116
- C2 -
4RLO
4
KS6B1_HUMAN
B:
[7-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
-
T
G
--
K
I
F
A
M
K
V
L
K
K
------------------------
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
-
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
---------------
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
----
I
L
K
C
K
--
L
N
L
P
---
P
--
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
----------------------------------------------------------------
35
PsiBlast_CBE
51.87
39%
-109
- C2 -
3A60
1
KS6B1_HUMAN
B:
[19-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
-
K
VTG
A
N
-
T
G
--
K
I
F
A
M
K
V
L
K
K
------------------------
K
--
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
-
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
--------------
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
-----
S
---
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
K
K
T
I
D
K
----
I
L
K
C
K
--
L
N
L
P
---
P
--
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
-
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
----------------------------------------------------------------
68
PsiBlast_CBE
51.04
31%
-80
- C2 -
5BML
1
ROCK1_HUMAN
A:
[20-399]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
----
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
-
T
R
--
K
V
Y
A
M
K
L
L
S
K
F
E
-
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
--
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
-
Y
----
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
--
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-------
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
--
L
T
F
P
---
D
D--
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
-----
D
I
D
T
S
N
F
D
D
-
L
-----
E
E
E
T
F
P
I
P
K
A
F
V
G
----
N
Q
-
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
------
83
PsiBlast_CBE
49.83
31%
-81
- C2 -
2ETK
1
ROCK1_HUMAN
A:
[20-399]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
----
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
-
T
R
--
K
V
Y
A
M
K
L
L
S
K
F
E
-
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
--
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
-
Y
----
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
--
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-------
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
--
L
T
F
P
---
D
DN
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
-----
D
I
D
T
S
N
F
D
D
-
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
----
N
Q
-
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
------
79
PsiBlast_CBE
49.37
31%
-80
- C2 -
3D9V
1
ROCK1_HUMAN
A:
[20-399]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
----
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
-
T
R
--
K
V
Y
A
M
K
L
L
S
K
F
E
-
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
--
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
-
Y
----
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
--
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-------
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
--
L
T
F
P
---
D
DN
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
-----
D
I
D
T
S
N
F
D
D
-
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
----
N
Q
-
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
------
67
PsiBlast_CBE
49.15
31%
-79
- C2 -
5BML
1
ROCK1_HUMAN
B:
[20-399]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
----
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
-
T
R
--
K
V
Y
A
M
K
L
L
S
K
F
E
-
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
--
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
-
Y
----
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
--
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
---
G
GD
G
Y
-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-------
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
--
L
T
F
P
---
D
DN
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
-----
D
I
D
T
S
N
F
D
D
-
L
E
E
---
E
E
E
T
F
P
I
P
K
A
F
V
G
----
N
Q
-
L
P
F
V
G
F
T
Y
Y
S
N
---------
70
PsiBlast_CBE
49.12
31%
-79
- C2 -
4YVE
1
ROCK1_HUMAN
A:
[20-399]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
----
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
-
T
R
--
K
V
Y
A
M
K
L
L
S
K
F
E
-
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
--
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
-
Y
----
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
--
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
----------GY---
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-------
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
--
L
T
F
P
---
D
DN
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
-----
D
I
D
T
S
N
F
D
D
-
L
------
E
E
T
F
P
I
P
K
A
F
V
G
----
N
Q
-
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
------
72
PsiBlast_CBE
48.96
31%
-78
- C2 -
4YVC
1
ROCK1_HUMAN
A:
[20-399]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
----
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
-
T
R
--
K
V
Y
A
M
K
L
L
S
K
F
E
-
M
I
-
K
-----
F
F
W
E
E
R
D
I
M
A
F
A
N
S
--
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
-
Y
----
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
--
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-------
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
--
L
T
F
P
---
D
DN
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
-----
D
I
D
T
S
N
F
D
D
-
L
-------
E
T
F
P
I
P
K
A
F
V
G
----
N
Q
-
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
------
69
PsiBlast_CBE
48.59
31%
-77
- C2 -
4YVE
1
ROCK1_HUMAN
B:
[20-399]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
----
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
-
T
R
--
K
V
Y
A
M
K
L
L
S
K
F
E
-
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
--
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
-
Y
----
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
--
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
---
G
GD
G
Y
-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-------
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
--
L
T
F
P
---
D
DN
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
-----
D
I
D
T
S
N
F
D
D
-
L
-----
E
E
E
T
F
P
I
P
K
A
F
V
G
----
N
Q
-
L
P
F
V
G
F
T
Y
Y
S
N
---------
98
PsiBlast_CBE
48.08
31%
-78
- C2 -
2V55
1
ROCK1_HUMAN
A:
[20-399]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
----
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
-
T
R
--
K
V
Y
A
M
K
L
L
S
K
F
E
-
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
--
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
-
Y
----
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
--
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
---
G
GD
G
Y
-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-------
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
--
L
T
F
P
---
D
DN
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
-----
D
I
D
T
S
N
F
D
D
-
L
------
E
E
T
F
P
I
P
K
A
F
V
G
----
N
Q
-
L
P
F
V
G
F
T
Y
Y
S
N
R
R
-------
81
PsiBlast_CBE
47.74
31%
-76
- C2 -
2ETR
1
ROCK1_HUMAN
A:
[20-399]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
----
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
-
T
R
--
K
V
Y
A
M
K
L
L
S
K
F
E
-
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
--
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
-
Y
----
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
--
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-------
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
--
L
T
F
P
---
D
DN
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
-----
D
I
D
T
S
N
F
D
D
-
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
----
N
Q
-
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
------
82
PsiBlast_CBE
47.09
31%
-78
- C2 -
2ETK
1
ROCK1_HUMAN
B:
[20-399]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
----
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
-
T
R
--
K
V
Y
A
M
K
L
L
S
K
F
E
-
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
--
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
-
Y
----
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
--
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
---
G
GD
G
Y
-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-------
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
--
L
T
F
P
---
D
DN
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
-----
D
I
D
T
S
N
F
D
D
-
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
----
N
Q
-
L
P
F
V
G
F
T
Y
Y
S
N
---------
71
PsiBlast_CBE
46.50
31%
-78
- C2 -
4YVC
1
ROCK1_HUMAN
B:
[20-399]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
----
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
-
T
R
--
K
V
Y
A
M
K
L
L
S
K
F
E
-
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
--
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
-
Y
----
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
--
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
---
G
GD
G
Y
-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-------
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
--
L
T
F
P
---
D
DN
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
-----
D
I
D
T
S
N
F
D
D
-
L
------
E
E
T
F
P
I
P
K
A
F
V
G
----
N
Q
-
L
P
F
V
G
F
T
Y
Y
S
N
---------
78
PsiBlast_CBE
46.24
31%
-77
- C2 -
3D9V
1
ROCK1_HUMAN
B:
[20-399]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
----
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
-
T
R
--
K
V
Y
A
M
K
L
L
S
K
F
E
-
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
--
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
-
Y
----
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
--
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
---
G
GD
G
Y
-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-------
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
--
L
T
F
P
---
D
DN
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
-----
D
I
D
T
S
N
F
D
D
-
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
----
N
Q
-
L
P
F
V
G
F
T
Y
Y
S
N
---------
85
PsiBlast_CBE
46.08
31%
-76
- C2 -
2ESM
1
ROCK1_HUMAN
A:
[20-399]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
----
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
-
T
R
--
K
V
Y
A
M
K
L
L
S
K
F
E
-
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
--
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
-
Y
----
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
--
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
---
G
GDGY-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-------
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
--
L
T
F
P
---
D
DN
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
-----
D
I
D
T
S
N
F
D
D
-
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
----
N
Q
-
L
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
------
80
PsiBlast_CBE
45.27
31%
-76
- C2 -
2ETR
1
ROCK1_HUMAN
B:
[20-399]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
----
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
-
T
R
--
K
V
Y
A
M
K
L
L
S
K
F
E
-
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
--
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
-
Y
----
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
--
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
---
G
GD
G
Y
-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-------
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
--
L
T
F
P
---
D
DN
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
-----
D
I
D
T
S
N
F
D
D
-
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
----
N
Q
-
L
P
F
V
G
F
T
Y
Y
S
N
---------
84
PsiBlast_CBE
45.12
31%
-73
- C2 -
2ESM
1
ROCK1_HUMAN
B:
[20-399]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
K
S
E
V
N
S
D
C
L
L
D
G
L
D
A
L
V
Y
D
L
D
F
P
A
L
R
K
N
K
N
I
D
N
F
L
S
R
Y
K
D
T
I
N
K
I
R
D
L
R
M
K
A
----
E
D
Y
E
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
-
H
---
K
S
-
T
R
--
K
V
Y
A
M
K
L
L
S
K
F
E
-
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
N
S
--
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
-
N
L
M
S
-
N
-
Y
----
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
-
S
-
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
D
-
K
S
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
--
T
A
-
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
-----
Q
---
G
GD
G
Y
-
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
-
D
T
P
F
-------
Y
A
D
S
L
V
G
T
Y
S
K
I
M
N
H
K
N
S
--
L
T
F
P
---
D
DN
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
-
D
R
E
V
R
L
G
---
R
N
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
---
W
A
W
E
T
L
R
D
T
V
A
P
V
V
P
D
L
S
S
-----
D
I
D
T
S
N
F
D
D
-
L
E
E
D
K
G
E
E
E
T
F
P
I
P
K
A
F
V
G
----
N
Q
-
L
P
F
V
G
F
T
Y
Y
S
N
---------