@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MYLK4_HUMAN: (2015-10-15 )
MLKVKRLEEFNTCYNSNQLEKMAFFQCREEVEKVKCFLEKNSGDQDSRSGHNEAKEVWSNADLTERMPVKSKRTSALAVDIPAPPAPFDHRIVTAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSDHKLHSRLNAQKKKNRGSDAQDFVTK
Atome Classification :
(81 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140--.---.---.------.------...-..150.......160........170.......180.......190..---.----------------------------------....200.......210.......220.......230..--...-.-.-240.--.--.......250.....---..-260.......270......--.280.......290.......300.......310.......320.......330.......340.......350.......360-----.......370.......380......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLK
V
K
R
L
E
E
F
N
T
CYNS
N
Q
L
E
K
M
A
F
F
Q
C
R
E
E
V
E
K
V
K
C
F
L
EKNSGDQDSRSG
H
N
E
A
K
E
V
WSNAD
L
T
ERMPVKSKRT
S
A
L
A
V
DIPAPPAPFDH
R
I
V
T
AKQGAVN
S
F
Y
T
V
S
K
T
E
I
LGGGRFG
Q
V
H
K
C
E
E
TAT
G
L
K
L
A
A
K
I
I
K
TR----G---M---K------
D
------
K
E
E
-
V
K
N
E
I
S
V
M
N
QLD
H
A
-
N
L
I
Q
L
Y
D
A
FESKN
D
I
V
L
V
M
E
YVD
G
G
E
L
F
D
R
I
I
D---E----------------------------------SY
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
DLKPE
N
I
L
--
C
VN-R-D-A--
K
--
Q
--
I
K
I
I
D
F
G
L
A
RRYKPR---
E
K
-
L
K
V
NFGTPEFLAPEVVNYD--FVSF
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
SGL
S
P
FLGDN
D
A
E
T
L
N
N
I
L
A
C
RWDL
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
IKEKS
W
R
I
S
A
S
E
ALKHPWLS-----
D
H
K
L
H
S
R
L
N
A
Q
K
KKNRGS
D
A
Q
D
FVTK
118
HHSearch
88.52
100%
-116
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[65-358]
-------------------------------------------------------------------------------
D
I
P
A
P
P
A
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
----
G
---
M
---
K
------
D
------
K
E
E
-
V
K
N
E
I
S
V
M
N
Q
L
D
H
A
-
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
---
E
----------------------------------
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
--
C
V
N
-
R
-
D
-
A
--
K
--
Q
--
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
---
E
K
-
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
--
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
-----
D
H
K
L
H
S
R
L
S
A
Q
---------------
1
PsiBlast_PDB
88.28
99%
-116
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[65-358]
-------------------------------------------------------------------------------
D
I
P
A
P
P
A
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
----
G
---
M
---
K
------
D
------
K
E
E
-
V
K
N
E
I
S
V
M
N
Q
L
D
H
A
-
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
---
E
----------------------------------
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
--
C
V
N
-
R
-
D
-
A
--
K
--
Q
--
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
---
E
K
-
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
--
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
-----
D
H
K
L
H
S
R
L
S
A
Q
---------------
21
PsiBlast_CBE
87.51
99%
-121
- C1 -
2X4F
3
MYLK4_HUMAN
B:
[66-355]
--------------------------------------------------------------------------------
I
P
A
P
P
A
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
G
G
--
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
----
G
---
M
---
K
------
D
------
K
E
E
-
V
K
N
E
I
S
V
M
N
Q
L
D
H
A
-
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
---
E
----------------------------------
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
--
C
V
N
-
R
-
D
-
A
--
K
--
Q
--
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
---
E
K
-
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
--
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
-----
D
H
K
L
H
S
R
L
------------------
12
PsiBlast_PDB
71.36
46%
-115
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[6-277]
-----------------------------------------------------------------------------------------------
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
---
S
---
R
ASR
R
G
V
S
------
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
---
Q
----------------------------------
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
K
-
N
-
I
--
P
I
P
H
--
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
-----
P
V
D
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
-
34
PsiBlast_CBE
70.07
46%
-114
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[6-277]
-----------------------------------------------------------------------------------------------
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
---
S
---
R
ASRRGV
S
------
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
---
Q
----------------------------------
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
K
-
N
-
I
--
P
IP
H
--
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
-----
P
V
D
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
-
6
PsiBlast_PDB
69.39
46%
-115
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[4-277]
---------------------------------------------------------------------------------------------
T
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
---
S
---
R
------
A
SRRGVC
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
-
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
---
Q
----------------------------------
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
K
-
N
-
I
--
P
I
P
H
--
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
-----
P
V
D
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
-
35
PsiBlast_CBE
69.26
46%
-117
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[6-277]
-----------------------------------------------------------------------------------------------
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
---
S
---
R
ASR
R
G
V
S
------
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
---
Q
----------------------------------
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
K
-
N
-
I
--
P
I
P
H
--
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
-----
P
V
D
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
-
33
PsiBlast_CBE
69.09
46%
-115
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[6-277]
-----------------------------------------------------------------------------------------------
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
---
S
---
R
ASRRGV
S
------
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
---
Q
----------------------------------
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
K
-
N
-
I
--
P
IP
H
--
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
-----
P
V
D
N
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
-
13
PsiBlast_PDB
68.72
44%
-113
- C1 -
4B4L
3
DAPK1_HUMAN
A:
[7-277]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
K
P
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
A
58
PsiBlast_CBE
68.44
44%
-117
- C1 -
4UV0
1
?
A:
[7-277]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
K
D
T
Q
Q
A
L
S
R
K
A
C
A
V
N
M
E
K
F
K
K
F
A
A
R
55
PsiBlast_CBE
68.23
44%
-116
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
24
PsiBlast_CBE
68.19
46%
-115
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[4-277]
---------------------------------------------------------------------------------------------
T
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
----
Q
---
S
---
R
------
A
SRRGVC
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
-
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
---
Q
----------------------------------
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
K
-
N
-
I
--
P
I
P
H
--
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
---
V
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
-----
P
V
D
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
-
14
PsiBlast_PDB
68.03
44%
-116
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
60
PsiBlast_CBE
67.15
44%
-114
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
K
P
R
--
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
47
PsiBlast_CBE
66.47
44%
-105
- C1 -
3EH9
1
DAPK1_HUMAN
A:
[4-274]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRGVS-
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
P
Q
F
E
---------------------
16
PsiBlast_PDB
66.32
43%
-113
- C1 -
4TXC
7
DAPK1_HUMAN
A:
[21-294]
--------------------------------------------------------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
-------------------------
20
PsiBlast_PDB
66.10
44%
-115
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
K
------------------------
46
PsiBlast_CBE
65.97
44%
-104
- C1 -
3EHA
1
DAPK1_HUMAN
A:
[4-274]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
P
Q
F
E
---------------------
18
PsiBlast_PDB
64.63
44%
-104
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
PR
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
P
Q
F
E
---------------------
54
PsiBlast_CBE
64.15
44%
-101
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
P
Q
F
E
---------------------
56
PsiBlast_CBE
63.99
44%
-112
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------
53
PsiBlast_CBE
63.76
44%
-104
- C1 -
1IG1
1
DAPK1_HUMAN
A:
[4-274]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
P
Q
F
E
---------------------
61
PsiBlast_CBE
63.47
44%
-104
- C1 -
3GU7
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
P
Q
F
E
---------------------
136
HHSearch
63.45
39%
-109
- C1 -
3Q5I
1
?
A:
[28-307]
---------------------------------------------------------------------------------------------
R
K
K
E
G
K
I
G
E
S
Y
F
K
V
--
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
-------------
K
------
F
------
H
E
E
-
I
Y
N
E
I
S
L
L
K
S
L
D
H
P
-
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
---
R
-----------------------------------
H
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
--
L
E
N
-
K
-
N
-
S
L-
L
--
N
--
I
K
I
V
D
F
G
L
S
S
F
F
S
K
D
---
Y
K
-
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
K
K
---
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
N
D
Q
D
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
A
L
N
S
R
W
I
K
-----
K
Y
A
N
N
I
N
K
S
D
Q
K
T
L
C
G
A
L
S
N
M
R
K
F
E
G
71
PsiBlast_CBE
63.32
40%
-108
- C1 -
3LM0
2
ST17B_HUMAN
A:
[27-291]
----------------------------------------------------------------------------------------------------
N
N
F
Y
I
L
T
S
K
E
-
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
RR--
G
---
Q
---
D
------
C
------
R
A
E
-
I
L
H
E
I
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
---
E
L---------------------------------
A
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
--
L
S
S
I
Y
-
P
-
L
--
G
--
D
--
I
K
I
V
D
F
G
M
S
R
K
I
-------------
M
G
T
P
E
Y
L
A
P
E
I
L
N
Y
D
--
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
D
N
Q
E
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
Q
-----
Q
W
D
F
E
N
L
F
H
P
----------------
64
PsiBlast_CBE
63.13
44%
-102
- C1 -
3GU4
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
P
Q
F
E
---------------------
63
PsiBlast_CBE
63.05
44%
-104
- C1 -
3GU5
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
P
Q
F
E
---------------------
62
PsiBlast_CBE
62.92
44%
-103
- C1 -
3GU6
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
P
Q
F
E
---------------------
65
PsiBlast_CBE
62.91
44%
-106
- C1 -
3GUB
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
Q
F
-----------------------
66
PsiBlast_CBE
62.59
44%
-105
- C1 -
3GU8
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
Q
F
-----------------------
39
PsiBlast_CBE
62.59
44%
-130
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[7-275]
-------------------------------------------------------------------------------------------------
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----------------------VS----
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
--------------------------------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
--------------
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------
70
PsiBlast_CBE
62.46
40%
-111
- C1 -
3LM5
1
ST17B_HUMAN
A:
[27-291]
----------------------------------------------------------------------------------------------------
N
N
F
Y
I
L
T
S
K
E
-
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
RR--
G
---
Q
---
D
------
C
------
R
A
E
-
I
L
H
E
I
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
---
E
L----------------------------------
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
--
L
S
S
I
Y
-
P
-
L
--
G
--
D
--
I
K
I
V
D
F
G
M
S
R
K
I
-------------
M
G
T
P
E
Y
L
A
P
E
I
L
N
Y
D
--
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
D
N
Q
E
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
Q
-----
Q
W
D
F
E
N
L
-------------------
59
PsiBlast_CBE
62.41
44%
-102
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
-------------------------
43
PsiBlast_CBE
62.13
44%
-102
- C1 -
4YPD
1
DAPK1_HUMAN
A:
[4-274]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
P
Q
F
E
K
--------------------
51
PsiBlast_CBE
62.00
44%
-104
- C1 -
1JKL
1
DAPK1_HUMAN
A:
[4-274]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
P
Q
F
E
---------------------
52
PsiBlast_CBE
61.98
44%
-104
- C1 -
1JKK
1
DAPK1_HUMAN
A:
[4-274]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
F
------------------------
44
PsiBlast_CBE
61.80
44%
-102
- C1 -
4YO4
1
DAPK1_HUMAN
A:
[4-274]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
Q
F
E
K
---------------------
50
PsiBlast_CBE
61.26
44%
-103
- C1 -
1P4F
1
DAPK1_HUMAN
A:
[4-274]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
--------------------------------------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
---
R
-
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
E
-
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-----
P
Q
F
-----------------------
79
PsiBlast_CBE
61.03
40%
-119
- C1 -
3HX4
3
?
A:
[57-312]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
--------------------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
129
HHSearch
60.66
34%
-109
- C1 -
3HKO
2
?
A:
[24-336]
---------------------------------------------------------------------------------------------------
L
Q
K
K
Y
H
L
K
--
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q--------
K
------
D
------
V
E
R
-
I
K
T
E
V
R
L
M
K
K
L
H
H
P
-
N
I
A
R
L
Y
E
V
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
D
D
STG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
--
F
S
T
-
N
-
K
-
S
--
F
--
E
--
I
K
L
V
D
F
G
L
S
K
E
F
Y
K
L
NNG-------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
T
NE
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
A
D
T
I
S
Q
V
L
N
K
K
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
-----
Q
F
S
D
K
I
Y
K
M
S
----------------
69
PsiBlast_CBE
60.64
38%
-111
- C1 -
2JC6
1
KCC1D_HUMAN
A:
[28-301]
-------------------------------------------------------------------------------------------------------------
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
K
----
A
-----------------------
S
S
I
E
N
E
I
A
V
L
R
K
I
K
H
E
-
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---
K
----------------------------------
G
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
--
Y
Y
S
-
Q
-
D
-
E
--
E
S
-
K
--
I
M
I
S
------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
--
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
S
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
GDTAL
N
K
N
I
H
E
S
V
S
A
Q
I
R
K
N
F
A
K
S
K
W
R
Q
A
F
N
41
PsiBlast_CBE
60.51
44%
-119
- C1 -
3ZXT
1
DAPK1_HUMAN
B:
[7-275]
-------------------------------------------------------------------------------------------------
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
RRGVS-
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
--------------
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------
40
PsiBlast_CBE
60.03
44%
-120
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[5-275]
-----------------------------------------------------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
---
K
------
S
SRRGVS
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
-
N
-
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
---------------
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------
42
PsiBlast_CBE
59.99
44%
-121
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[7-275]
-------------------------------------------------------------------------------------------------
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
----
R
---
T
-----------------
R
E
D
-
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
-
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
--
L
L
D
-
R
---
V
--
P
--
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
----------------
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
-------------------------------
68
PsiBlast_CBE
59.43
38%
-113
- C1 -
2JC6
1
KCC1D_HUMAN
C:
[28-301]
-------------------------------------------------------------------------------------------------------------
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
K
----
A
------------------------S
I
E
N
E
I
A
V
L
R
K
I
K
H
E
-
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---
K
----------------------------------
G
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
--
Y
Y
S
-
Q
-
D
-
E
--
E
S-
K
--
I
M
I
S
------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
--
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
S
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
A
GDTAL
N
K
N
I
H
E
S
V
S
A
Q
I
R
K
N
F
A
K
S
K
W
R
Q
A
F
N
135
HHSearch
59.42
35%
-111
- C1 -
3F3Z
5
?
A:
[6-267]
--------------------------------------------------------------------------------------------------
D
I
N
Q
Y
Y
T
L
E
--
N
T
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
P
K
Y
----
F
---
V
---
E
------
D
------
V
D
R
-
F
K
Q
E
I
E
I
M
K
S
L
D
H
P
-
N
I
I
R
L
Y
E
T
F
E
D
N
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
H
---
K
-----------------------------------
R
V
F
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
--
F
L
T
-
D
S
P
-
D
--
S
--
P
--
L
K
L
I
D
F
G
L
A
A
R
F
K
P
G
---
K
M
-
M
R
T
K
V
G
T
P
Y
Y
V
S
P
Q
V
L
E
G
---
L
Y
G
P
E
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
S
A
P
T
D
S
E
V
M
L
K
I
R
E
G
T
F
T
F
P
E
K
D
W
L
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
T
S
L
Q
A
L
E
H
E
W
F
E
-----
K
Q
L
S
S
S
P
R
N
L
L
---------------
128
HHSearch
58.94
37%
-112
- C1 -
3LIJ
1
?
A:
[29-298]
---------------------------------------------------------------------------------------------
T
S
K
K
G
H
L
S
E
M
Y
Q
R
V
--
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
-------------
S
------
S
------
N
S
K
-
L
L
E
E
V
A
V
L
K
L
L
D
H
P
-
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
--------------------------------------
R
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
--
L
E
S
-
K
-
E
K
D
--
A
--
L
--
I
K
I
V
D
F
G
L
S
A
V
F
E
N
Q
---
K
K
-
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
K
K
---
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
D
Q
E
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
-----
E
M
C
S
K
K
E
S
L
P
S
L
A
N
A
I
E
N
M
R
K
F
Q
N
S
Q
132
HHSearch
57.87
39%
-105
- C1 -
3NYV
1
?
A:
[22-287]
-------------------------------------------------------------------------------------------------
A
I
F
S
D
R
Y
K
G
Q
--
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
KQK
T
------
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
-----------------------------------
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
--
L
E
S
-
K
-
S
K
D
--
A
--
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
133
HHSearch
57.86
38%
-101
- C1 -
3MWU
1
?
A:
[16-282]
-----------------------------------------------------------------------------------------------
F
Q
G
T
F
A
E
R
Y
N
I
V
--
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
----
S
AK-
N
---
K
------
D
------
T
S
T
-
I
L
R
E
V
E
L
L
K
K
L
D
H
P
-
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
---
R
-----------------------------------
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
--
L
E
S
-
K
-
E
K
D
--
C
--
D
--
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
--------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
---
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
-----
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
98
PsiBlast_CBE
57.82
40%
-107
- C1 -
3UPX
1
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
74
PsiBlast_CBE
57.51
37%
-110
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[24-297]
-------------------------------------------------------------------------------------------------------------
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
--------------------------------
N
E
I
A
V
L
H
K
I
K
H
P
-
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---
K
----------------------------------
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
--
Y
Y
S
-
L
-
D
-
E
D-
S
--
K
--
I
M
I
S
D
F
---------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
GDTAL
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
---------
73
PsiBlast_CBE
56.09
37%
-103
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[24-297]
-------------------------------------------------------------------------------------------------------------
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
---------------------------------
N
E
I
A
V
L
H
K
I
K
H
P
-
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---
K
----------------------------------
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
--
Y
Y
S
-
L
-
D
-
E
D-
S
--
K
--
I
M
I
S
D
F
G
-------
G
---
S
V
-
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
GDTAL
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
---------
81
PsiBlast_CBE
56.01
40%
-108
- C1 -
4IFG
1
?
A:
[56-311]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
80
PsiBlast_CBE
55.46
40%
-108
- C1 -
4IHP
1
?
A:
[56-311]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
E
Q
I
S
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
88
PsiBlast_CBE
55.11
40%
-107
- C1 -
4WG4
1
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
76
PsiBlast_CBE
55.10
37%
-111
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[24-297]
-------------------------------------------------------------------------------------------------------------
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
-------------------------------
E
N
E
I
A
V
L
H
K
I
K
H
P
-
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---
K
----------------------------------
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
--
Y
Y
S
-
L
-
D
-
E
D-
S
--
K
--
I
M
I
S
D
F
----------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
--
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
GDTAL
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
82
PsiBlast_CBE
55.05
40%
-109
- C1 -
3KU2
1
?
A:
[56-311]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
87
PsiBlast_CBE
54.76
40%
-105
- C1 -
4WG5
1
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
96
PsiBlast_CBE
54.65
40%
-103
- C1 -
3V51
1
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
91
PsiBlast_CBE
54.64
40%
-103
- C1 -
4ONA
1
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
92
PsiBlast_CBE
54.58
40%
-105
- C1 -
4M84
1
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
106
PsiBlast_CBE
54.57
40%
-102
- C1 -
4MXA
1
?
A:
[34-289]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
100
PsiBlast_CBE
54.51
40%
-106
- C1 -
3T3U
5
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
134
HHSearch
54.41
39%
-108
- C1 -
4QOX
1
CDPK4_PLAF7
A:
[74-339]
--------------------------------------------------------------------------------------------------
V
F
N
E
Q
Y
K
G
I
--
K
I
L
G
K
G
S
F
G
E
V
I
L
S
R
D
K
H
T
G
H
E
Y
A
I
K
V
I
S
K
K
----
H
VKR
K
---
T
------
D
------
K
E
S
-
L
L
R
E
V
E
L
L
K
M
L
D
H
I
-
N
I
M
K
L
Y
E
F
F
E
D
N
N
Y
Y
Y
L
V
S
D
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
-----------------------------------
K
R
F
Y
E
I
D
A
A
R
I
I
K
Q
I
L
S
G
I
T
Y
M
H
K
N
N
V
V
H
R
D
L
K
P
E
N
I
L
--
L
E
T
-
K
-
N
--ED
M
--
I
--
I
K
I
I
D
F
G
L
S
T
H
F
E
Y
S
---------
K
I
G
T
A
Y
Y
I
A
P
D
V
L
H
G
T
---
Y
D
E
K
C
D
I
W
S
C
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
S
N
E
Y
D
I
L
K
K
V
E
A
G
K
Y
T
F
D
L
P
Q
F
K
K
I
S
D
K
A
K
D
L
I
K
K
M
L
M
Y
T
S
A
V
R
I
S
A
R
D
A
L
E
H
E
W
I
K
-----
M
M
T
S
K
L
E
L
S
I
A
N
I
R
Q
F
Q
S
T
Q
K
L
A
Q
A
A
90
PsiBlast_CBE
54.27
40%
-107
- C1 -
4TZR
1
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
75
PsiBlast_CBE
53.97
37%
-107
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[24-297]
-------------------------------------------------------------------------------------------------------------
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
----------------------------------
E
I
A
V
L
H
K
I
K
H
P
-
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---
K
----------------------------------
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
--
Y
Y
S
-
L
-
D
-
E
D-
S
--
K
--
I
M
I
S
D
F
-------------
V
-
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
GDTAL
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
97
PsiBlast_CBE
53.92
40%
-106
- C1 -
3UPZ
1
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
99
PsiBlast_CBE
53.83
40%
-107
- C1 -
3T3V
2
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
107
PsiBlast_CBE
53.52
40%
-104
- C1 -
4MX9
1
?
A:
[34-289]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
103
PsiBlast_CBE
53.34
40%
-104
- C1 -
3N51
3
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
95
PsiBlast_CBE
53.26
40%
-105
- C1 -
3V5P
1
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
102
PsiBlast_CBE
53.10
40%
-108
- C1 -
3SX9
1
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
78
PsiBlast_CBE
52.92
40%
-103
- C1 -
3MA6
1
?
A:
[39-294]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
-
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
----------------------
130
HHSearch
52.51
35%
-96
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-273]
-------------------------------------------------------------------------------------------------
T
R
F
T
E
E
Y
Q
L
F
--
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
----
K
---
L
SA-
R
------
D
------
H
Q
K
-
L
E
R
E
A
R
I
C
R
L
L
K
H
P
-
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
---
R
-----------------------------------
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
--
L
A
S
-
K
L
K
-
G
--
A
--
A
--
V
K
L
A
D
F
G
L
A
I
E
V
E
G
E
---
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
--
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
-----
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
89
PsiBlast_CBE
52.34
40%
-104
- C1 -
4WG3
1
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
101
PsiBlast_CBE
52.27
40%
-102
- C1 -
3SXF
3
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
Q
K
T
---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
94
PsiBlast_CBE
52.25
40%
-104
- C1 -
3V5T
1
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
93
PsiBlast_CBE
52.13
40%
-104
- C1 -
4JBV
1
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
104
PsiBlast_CBE
51.86
40%
-104
- C1 -
3I7B
4
?
A:
[33-288]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QKT---
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
77
PsiBlast_CBE
50.62
40%
-97
- C1 -
3MA6
1
?
B:
[39-294]
--------------------------------------------------------------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
----
Q
---
V
---
K
QT----
D
------
K
E
S
-
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
-
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---
R
----------------------------------
K
-
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
LE
S
K
S
-
K
-
D
-
A
-----
N
--
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
---
K
K
-
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
--
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
-----
T
Y
T
-----------------------
137
HHSearch
43.12
37%
-96
- C1 -
4MVF
2
CDPK2_PLAFK
A:
[50-315]
----------------------------------------------------------------------------------------------
C
H
S
G
K
L
E
D
K
Y
I
I
D
--
E
K
L
G
Q
G
T
Y
G
C
V
Y
K
G
I
D
K
V
T
N
Q
L
Y
A
I
K
E
E
K
K
D
----
R
---
L
---
K
------
N
------
I
N
R
-
F
F
Q
E
I
E
I
M
K
K
L
D
H
P
-
N
I
V
K
L
Y
E
T
Y
E
N
D
N
Y
I
Y
L
I
M
E
L
C
S
G
R
E
L
F
D
S
I
I
E
--------------------------------------
N
G
S
F
T
E
K
N
A
A
T
I
M
K
Q
I
F
S
A
I
F
Y
L
H
S
L
N
I
V
H
R
D
L
K
P
E
N
F
L
--
F
Q
S
-
E
-
N
K
D
--
S
--
L
--
L
K
I
I
D
F
G
L
S
K
N
L
---------------------------
K
---
Y
D
K
K
C
D
I
W
S
S
G
V
I
M
Y
T
L
L
C
G
Y
P
P
F
Y
----------------
C
F
Y
E
N
D
W
G
S
I
S
S
D
A
K
N
L
I
T
K
L
L
T
Y
N
P
N
E
R
C
T
I
E
E
A
L
N
H
P
W
I
T
-----
Q
M
T
K
S
H
V
E
L
S
S
T
L
L
K
N
L
K
N
F
K
K
E
N
E
L